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Sci Rep ; 10(1): 21261, 2020 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-33277523


This paper reports on the design, development, and test of a multi-channel wireless micro-electrocorticography (µECoG) system. The system consists of a semi-implantable, ultra-compact recording unit and an external unit, interfaced through a 2.4 GHz radio frequency data telemetry link with 2 Mbps (partially used) data transfer rate. Encased in a 3D-printed 2.9 cm × 2.9 cm × 2.5 cm cubic package, the semi-implantable recording unit consists of a microelectrode array, a vertically-stacked PCB platform containing off-the-shelf components, and commercially-available small-size 3.7-V, 50 mAh lithium-ion batteries. Two versions of microelectrode array were developed for the recording unit: a rigid 4 × 2 microelectrode array, and a flexible 12 × 6 microelectrode array, 36 of which routed to bonding pads for actual recording. The external unit comprises a transceiver board, a data acquisition board, and a host computer, on which reconstruction of the received signals is performed. After development, assembly, and integration, the system was tested and validated in vivo on anesthetized rats. The system successfully recorded both spontaneous and evoked activities from the brain of the subject.

Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 898-901, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018129


This paper introduces a lossless approach for data reduction in multi-channel neural recording microsystems. The proposed approach benefits from eliminating the redundancy that exists in the signals recorded from the same space in the brain, e.g., local field potentials in intra-cortical recording from neighboring recording sites. In this approach, a single baseline component is extracted from the original neural signals, which is treated as the component all the channels share in common. What remains is a set of channel-specific difference components, which are much smaller in word length compared to the sample size of the original neural signals. To make the proposed approach more efficient in data reduction, length of the difference component words is adaptively determined according to their instantaneous amplitudes. This approach is low in both computational and hardware complexity, which introduces it as an attractive suggestion for high-density neural recording brain implants. Applied on multi-channel neural signals intra-cortically recorded using 16 multi-electrode array, the data is reduced by around 48%. Designed in TSMC 130-nm standard CMOS technology, hardware implementation of this technique for 16 parallel channels occupies a silicon area of 0.06 mm2, and dissipates 6.4 µW of power per channel when operates at VDD=1.2V and 400 kHz.Clinical Relevance- This paper presents a lossless data reduction technique, dedicated to brain-implantable neural recording devices. Such devices are developed for clinical applications such as the treatment of epilepsy, neuro-prostheses, and brain-machine interfacing for therapeutic purposes.

Interfaces Cérebro-Computador , Procedimentos Cirúrgicos Reconstrutivos , Encéfalo , Próteses e Implantes , Registros