Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Mais filtros

Base de dados
Intervalo de ano de publicação
J Comp Eff Res ; 10(8): 673-683, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33860672


Background: The effect of midodrine on lactate clearance has not been assessed in critically ill patients yet. Objective: The goal of this study was to assess the effect of adjunctive midodrine therapy on lactate clearance in patients with septic shock. Materials & methods: Patients with septic shock were assigned to receive either adjunctive midodrine 10 mg three-times a day for 5 days (midodrine group = 15 patients) or not (control group = 13 patients). Results: The lactate clearance was significantly faster in the midodrine group than the control group (p = 0.049) with a large effect size (ηp2 = 0.141). Conclusion: When midodrine was added to intravenous vasopressors, it significantly accelerated lactate clearance in patients with septic shock. Trial registration number: IRCT20100228003449N25 (

Midodrina , Choque Séptico , Humanos , Ácido Láctico , Midodrina/uso terapêutico , Projetos Piloto , Choque Séptico/tratamento farmacológico , Vasoconstritores/uso terapêutico
Int J Cardiovasc Imaging ; 37(5): 1629-1636, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33454898


To assess imaging data in COVID-19 patients and its association with clinical course and survival and 86 consecutive patients (52 males, 34 females, mean age = 58.8 year) with documented COVID-19 infection were included. Seventy-eight patients (91%) were in severe stage of the disease. All patients underwent transthoracic echocardiography. Mean LVEF was 48.1% and mean estimated systolic pulmonary artery pressure (sPAP) was 27.9 mmHg. LV diastolic dysfunction was mildly abnormal in 49 patients (57.6%) and moderately abnormal in 7 cases (8.2%). Pericardial effusion was present in 5/86 (minimal in size in 3 cases and mild- moderate in 2). In 32/86 cases (37.2%), the severity of infection progressed from "severe" to "critical". Eleven patients (12.8%) died. sPAP and computed tomography score were associated with disease progression (P value = 0.002, 0.002 respectively). Tricuspid annular plane systolic excursion (TAPSE) was significantly higher in patients with no disease progression compared with those who deteriorated (P value = 0.005). Pericardial effusion (minimal, mild or moderate) was detected more often in progressive disease (P = 0.03). sPAP was significantly lower among survivors (P value = 0.007). Echocardiographic findings (including systolic PAP, TAPSE and pericardial effusion), total CT score may have prognostic and therapeutic implication in COVID-19 patients.

COVID-19/fisiopatologia , Ecocardiografia , Derrame Pericárdico/diagnóstico por imagem , Disfunção Ventricular Esquerda/diagnóstico por imagem , Pressão Sanguínea/fisiologia , COVID-19/mortalidade , Progressão da Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Derrame Pericárdico/fisiopatologia , Índice de Gravidade de Doença , Volume Sistólico/fisiologia , Disfunção Ventricular Esquerda/fisiopatologia
Int J Surg Pathol ; 29(2): 135-145, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32552178


Background. A novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been affecting almost all nations around the world. Most infected patients who have been admitted to intensive care units show SARS signs. In this study, we aimed to achieve a better understanding of pathological alterations that take place during the novel coronavirus infection in most presumed affected organs. Methods. We performed postmortem core needle biopsies from lung, heart, and liver on 7 deceased patients who had died of coronavirus disease 2019. Prepared tissue sections were observed by 2 expert pathologists. Results. Diffuse alveolar damage was the main pathologic finding in the lung tissue samples. Patients with hospitalization durations of more than 10 days showed evidence of organization. Multinucleated cells in alveolar spaces and alveolar walls, atypical enlarged cells, accumulation of macrophages in alveolar spaces, and congestion of vascular channels were the other histopathologic alteration of the lung. None of our heart biopsy samples met the criteria for myocarditis. Liver biopsies showed congestion, micro- and macro-vesicular changes, and minimal to mild portal inflammation, in the majority of cases. Conclusions. Similar to the previous coronavirus infection in 2003, the main pathologic finding in the lung was diffuse alveolar damage with a pattern of organization in prolonged cases. The SARS-CoV-2 infection does not cause myocarditis, and the ischemia of myocardium is the most probable justification of the observed pathologic changes in the heart. Liver tissue sections mostly showed nonspecific findings; however, ischemia of the liver can be identified in some cases.

COVID-19/patologia , Fígado/patologia , Pulmão/patologia , Miocárdio/patologia , Idoso , Idoso de 80 Anos ou mais , Autopsia , Biópsia com Agulha de Grande Calibre , Feminino , Coração , Humanos , Masculino , Pessoa de Meia-Idade , SARS-CoV-2
Anadolu Kardiyol Derg ; 12(3): 200-5, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22366102


OBJECTIVE: Epicardial fat is an indirect contact with coronary arteries. There are some studies about the relationship between this fat and metabolic syndrome and it has considered as an indicator of cardiovascular risk. Several studies have addressed the association between epicardial fat thickness (EFT) and coronary artery disease (CAD) with conflicting results. The aim of our study was to evaluate the hypothesis that echocardiographic EFT thickness could be a marker severe CAD. METHODS: Overall, 315 cases who underwent coronary angiography were classified in two groups: Normal and CAD. Measurement of EFT was done with echocardiography. The difference between mean EFT in two groups was analyzed. Califf scoring considered for severity of CAD. Then the relationship between EFT and age, sex, body mass index (BMI), serum lipids and severity of CAD was evaluated. The obtained data were compared by using ANCOVA test, Pearson and Spearman's partial correlation analyses. RESULTS: The EFT in CAD group was significantly higher than in normal group (5.4 ± 1.9 mm vs 4.4 ± 1.8 mm, p=0.0001). EFT had a positive relationship with Califf scoring of diseased coronary arteries (r=0.158 p=0.04), low-density lipoprotein cholesterol (p=0.04), female gender (p=0.02), BMI (p=0.001) and serum triglyceride levels (p=0.04). CONCLUSION: This study shows an association between EFT thickness and severity of CAD.

Tecido Adiposo/anatomia & histologia , Doença da Artéria Coronariana/patologia , Pericárdio/diagnóstico por imagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Estudos de Casos e Controles , Angiografia Coronária , Doença da Artéria Coronariana/diagnóstico por imagem , Estudos Transversais , Complicações do Diabetes , Feminino , Humanos , Hipertensão/complicações , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Índice de Gravidade de Doença , Fumar , Ultrassonografia