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1.
Sensors (Basel) ; 21(19)2021 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-34640827

RESUMO

In general, a partially reflective surface (PRS) is mainly used to increase the gain of an antenna; some metallic objects placed on the PRS degrades the antenna performance because the objects change the periodic structure of the PRS. Herein, we propose a multifunctional PRS for smart block application. When a passenger passes over a smart block, the fare can be simultaneously collected and presented through the LED display. This requires high gain antenna with LED structure. The high gain characteristic helps the antenna identify passengers only when they pass over the block. The multifunctional PRS has a structure in which an LED can be placed in the horizontal direction while increasing the antenna gain. We used the antenna's polarization characteristics to prevent performance deterioration when LED lines are placed in the PRS. We built the proposed antenna and measured its performance: At 2.41 GHz, the efficiency was 81.4%, and the antenna gain was 18.3 dBi. Furthermore, the half-power beamwidth was 18°, confirming a directional radiation pattern.

2.
Sensors (Basel) ; 21(20)2021 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-34695978

RESUMO

We propose a deep neural network (DNN) to determine the matching circuit parameters for antenna impedance matching. The DNN determines the element values of the matching circuit without requiring a mathematical description of matching methods, and it approximates feasible solutions even for unimplementable inputs. For matching, the magnitude and phase of impedance should be known in general. In contrast, the element values of the matching circuit can be determined only using the impedance magnitude using the proposed DNN. A gamma-matching circuit consisting of a series capacitor and a parallel capacitor was applied to a conventional inverted-F antenna for impedance matching. For learning, the magnitude of input impedance S11 of the antenna was extracted according to the element values of the matching circuit. A total of 377 training samples and 66 validation samples were obtained. The DNN was then constructed considering the magnitude of impedance S11 as the input and the element values of the matching circuit as the output. During training, the loss converged as the number of epochs increased. In addition, the desired matching values for unlearned square and triangular waves were obtained during testing.

3.
Nat Commun ; 12(1): 4194, 2021 07 07.
Artigo em Inglês | MEDLINE | ID: mdl-34234144

RESUMO

Photomorphogenesis, light-mediated development, is an essential feature of all terrestrial plants. While chloroplast development and brassinosteroid (BR) signaling are known players in photomorphogenesis, proteins that regulate both pathways have yet to be identified. Here we report that DE-ETIOLATION IN THE DARK AND YELLOWING IN THE LIGHT (DAY), a membrane protein containing DnaJ-like domain, plays a dual-role in photomorphogenesis by stabilizing the BR receptor, BRI1, as well as a key enzyme in chlorophyll biosynthesis, POR. DAY localizes to both the endomembrane and chloroplasts via its first transmembrane domain and chloroplast transit peptide, respectively, and interacts with BRI1 and POR in their respective subcellular compartments. Using genetic analysis, we show that DAY acts independently on BR signaling and chlorophyll biogenesis. Collectively, this work uncovers DAY as a factor that simultaneously regulates BR signaling and chloroplast development, revealing a key regulator of photomorphogenesis that acts across cell compartments.


Assuntos
Proteínas de Arabidopsis/metabolismo , Proteínas de Choque Térmico HSP40/metabolismo , Proteínas de Membrana/metabolismo , Morfogênese/fisiologia , Proteínas Quinases/metabolismo , Arabidopsis/genética , Arabidopsis/crescimento & desenvolvimento , Arabidopsis/metabolismo , Proteínas de Arabidopsis/genética , Brassinosteroides/metabolismo , Clorofila/biossíntese , Cloroplastos/metabolismo , Estiolamento/fisiologia , Regulação da Expressão Gênica de Plantas/fisiologia , Técnicas de Silenciamento de Genes , Proteínas de Choque Térmico HSP40/genética , Proteínas de Choque Térmico HSP40/isolamento & purificação , Luz , Proteínas de Membrana/genética , Proteínas de Membrana/isolamento & purificação , Proteínas Associadas aos Microtúbulos/genética , Proteínas Associadas aos Microtúbulos/metabolismo , Morfogênese/efeitos da radiação , Mutação , Plantas Geneticamente Modificadas , Proteínas Quinases/genética , RNA-Seq , Proteínas Recombinantes/genética , Proteínas Recombinantes/isolamento & purificação , Proteínas Recombinantes/metabolismo , Plântula/crescimento & desenvolvimento , Transdução de Sinais/fisiologia
4.
J Craniofac Surg ; 32(4): 1307-1310, 2021 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-33177417

RESUMO

BACKGROUND: Reduction malarplasty has been popular among Asians with a wide facial width. In general, malar setback after bony resection is regarded as the standard objective of reduction malarplasty. However, unnecessary bony resection may lead to various postoperative complications. Therefore, we suggest the use of reduction malarplasty without bony resection to achieve a similar narrowing effect of the facial width, based on radiographic analysis of malar arch movement. PATIENTS AND METHODS: This retrospective study analyzed 48 patients with a wide midface who underwent reduction malarplasty between September 2018 and December 2019. We included 40 cases of advancement repositioning malarplasty (AR) without bony resection and 8 cases of setback reduction malarplasty (SR) with bony resection. The three-dimensional position of the malar arch expressed by coordinates (x, y, and z) on three-dimensional computed tomography scans was used to compare the positional change between the surgical methods. The paired t-test, Wilcoxon text, and independent t-test were used in data analysis, and statistical analysis was performed using SPSS 23.0 software. RESULTS: Medial and superior movement of the freed malar arch segment was significantly different between AR and SR (P < 0.05). Although medialization and superiorization were not significantly different between AR and SR, there was a significant difference in anterior-posterior movement between AR and SR (P < 0.05). CONCLUSION: The radiologic analysis based on malar arch movement between AR and SR showed similar narrowing effects on medialization and superiorization of the malar arch regardless of bony resection. Therefore, the AR can be effectively applied in case of arch dominant type or malar asymmetry. In addition, further comprehensive study including analysis on movement of facial soft tissue following malar bony movement is expected based on this study in near future.


Assuntos
Procedimentos Cirúrgicos Reconstrutivos , Zigoma , Humanos , Osteotomia , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Zigoma/diagnóstico por imagem , Zigoma/cirurgia
5.
Arch Plast Surg ; 47(6): 604-612, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33238349

RESUMO

BACKGROUND: Due to the anatomical complexity of the deep temporal fascia (DTF), practical guidelines for its safe harvest are lacking. However, since the upper temporal compartment (UTC) contains no vital structures, it may provide safe access for DTF harvest. This study aimed to identify the anatomical structures of the temporal compartment in Asian cadavers and to measure their dimensions to enable safe DTF harvest. METHODS: The anatomical structures surrounding the temporal compartment were identified in 27 hemifaces from 15 Korean cadavers. After dissection, digital images were acquired and craniometric landmarks were placed upon them to identify the boundaries of the temporal compartment. The horizontal and vertical lengths of the temporal compartment were measured and their surface areas were computationally assessed. Subsequently, differences in the results by sex were evaluated. RESULTS: The five-layer anatomical structure of the UTC was clearly visualized. The UTC was bounded by the temporal septa superiorly and inferiorly, the innominate fascia laterally, and the DTF medially. No vital structures were present within the UTC. The vertical and horizontal lengths of the UTC were 6.41±0.67 cm and 10.44±0.83 cm, respectively, and the surface area of the UTC was 48.52±5.65 cm2. No statistically significant differences were observed in any dimensions between male and female patients. CONCLUSIONS: During rhinoplasty, DTF can be harvested as an autologous graft material from the UTC. An anatomical understanding of the UTC will aid in the safe and simple harvest of a sufficient amount of DTF.

6.
Sensors (Basel) ; 20(21)2020 Oct 22.
Artigo em Inglês | MEDLINE | ID: mdl-33105822

RESUMO

A microstrip-to-slot line-fed miniaturized Vivaldi antenna using semicircular patch embedment is proposed in this study. The conventional Vivaldi antenna has ultrawide bandwidth, but suffers from low gain in the low-frequency band. The proposed antenna topology incorporates the embedment of semicircular patch elements into the side edge of the antenna. This enables the phases of electric fields at both ends of the antenna to be out of phase. Since the distance between the two ends are λL/2 where λL is the wavelength at a low operating frequency, this antenna topology can achieve the constructive addition of electrical fields at the radiating end, leading to gain enhancement at the chosen low frequency. In comparison with the conventional Vivaldi antenna, the proposed antenna has a wider bandwidth from 2.84 to 9.83 GHz. Moreover, the simulated result shows a gain enhancement of 5 dB at low frequency. This cannot be realized by the conventional low-band impedance matching techniques only relying on slotted topologies. The measured results of this proposed antenna with a size of 45 × 40 × 0.8 mm3 are in good agreement with the simulated results.

7.
Micromachines (Basel) ; 9(9)2018 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-30424390

RESUMO

Heat dissipation has become an important issue due to the miniaturization of various electronic devices. Various methods such as spray and nozzle coolers, heat sinks and so on are used for heat dissipation. However, the emergence of ferrofluids drastically improves the operating characteristics of electromagnetic systems and devices. A ferrofluid is a suspension containing 10-nm magnetic particles in a colloidal solution. This material exhibits paramagnetic behavior and is sensitive to magnetic field and temperature. In this study, heat transfer characteristics of ferrofluids in a rotating eccentric cylinder were investigated using the commercial code, COMSOL Multiphysics. Numerical results of the local Nusselt number, magnetophoretic force and velocity distributions were obtained from various eccentricities of the cylinder, and the results were graphically depicted with various flow conditions.

8.
Artigo em Inglês | MEDLINE | ID: mdl-30274349

RESUMO

Using the Culture-Work-Health model, this study investigates the factors influencing the quality of life of seafarers. This study conducted a survey of 320 seafarers who have lived and worked on a ship for more than six months. This self-administered questionnaire included questions on organizational culture and support, self-efficacy, perceived fatigue, as well as the quality of work life. Organizational culture and self-efficacy were identified as factors affecting the quality of work life, while organizational support was found to have an indirect effect through self-efficacy and perceived fatigue. The final model accounts for 63.1% of the variance in seafarers' quality of life. As such, this study shows that self-efficacy is important for the quality of life of seafarers, having both direct and indirect effects. Moreover, organizational support may prove to be the primary intervention point for relieving perceived fatigue and enhancing self-efficacy, thus improving the quality of work life.


Assuntos
Fadiga , Medicina Naval , Ocupações , Qualidade de Vida , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Cultura Organizacional , Percepção , Autoeficácia , Inquéritos e Questionários
9.
Microb Ecol ; 75(3): 720-728, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28993853

RESUMO

Analysis of mixed microbial populations responsible for the production of medium-chain-length polyhydroxyalkanoates (MCL-PHAs) under periodic substrate feeding in a sequencing batch reactor (SBR) was conducted. Regardless of activated sludge samples and the different MCL alkanoic acids used as the sole external carbon substrate, denaturing gradient gel electrophoresis analysis indicated that Pseudomonas aeruginosa was the dominant bacterium enriched during the SBR process. Several P. aeruginosa strains were isolated from the enriched activated sludge samples. The isolates were subdivided into two groups, one that produced only MCL-PHAs and another that produced both MCL- and short-chain-length PHAs. The SBR periodic feeding experiments with five representative MCL-PHA-producing Pseudomonas species revealed that P. aeruginosa has an advantage over other species that enables it to become dominant in the bacterial community.


Assuntos
Bactérias/metabolismo , Poli-Hidroxialcanoatos/biossíntese , Esgotos/microbiologia , Aerobiose , Bactérias/enzimologia , Bactérias/genética , Biodiversidade , Reatores Biológicos/microbiologia , Carbono/metabolismo , Técnicas de Cultura de Células , Meios de Cultura/química , DNA Bacteriano/genética , Ácidos Graxos/metabolismo , Microbiota , Pseudomonas/classificação , Pseudomonas/enzimologia , Pseudomonas/genética , Pseudomonas/metabolismo , Pseudomonas aeruginosa/enzimologia , Pseudomonas aeruginosa/genética , Pseudomonas aeruginosa/isolamento & purificação , Pseudomonas aeruginosa/metabolismo , RNA Ribossômico 16S/genética , Temperatura
10.
Nutr Res Pract ; 11(4): 300-306, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28765776

RESUMO

BACKGROUND/OBJECTIVES: The doubly labeled water (DLW) method is considered the gold standard for the measurement of total energy expenditure (TEE), which serves to estimate energy requirements. This study evaluated the accuracy of predictive dietary reference intake (DRI) equations for determining the estimated energy requirements (EER) of Korean adults by using the DLW as a reference method. SUBJECTS/METHODS: Seventy-one participants (35 men and 36 women) aged between 20 and 49 years were included in the study. The subjects' EER, calculated by using the DRI equation (EERDRI), was compared with their TEE measured by the DLW method (TEEDLW). RESULTS: The DRI equations for EER underestimated TEE by -36.3 kcal/day (-1.3%) in men and -104.5 kcal/day (-4.9%) in women. The percentages of accurate predictions among subjects were 77.1% in men and 62.9% in women. There was a strong linear correlation between EERDRI and TEEDLW (r=0.783, P<0.001 in men and r=0.810, P<0.001 in women). CONCLUSIONS: The present study supports the use of DRI prediction equations to determine EER in Korean adults. More studies are needed to confirm our results and to assess the validity of these equations in other population groups, including children, adolescents, and older adults.

11.
Colloids Surf B Biointerfaces ; 153: 95-103, 2017 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-28231500

RESUMO

Combination therapies are widely investigated cancer treatment modalities. Carbon based systems such as graphene oxide (GO), plasmonic nanoparticles such as silver nanoparticles (AgNPs), and the folate analog, methotrexate (MTX), have been separately studied for their potential anticancer effects. In this study, we combined these systems to develop AgNPs-embedded GO with conjugated MTX (MTX-GO/AgNPs) and studied their folate receptor-targeted anticancer effects. Results revealed successful formation of AgNPs on GO along with MTX conjugation as suggested by UV/visible, TEM, AFM, FTIR, and XRD analysis. Folate receptor-positive MCF-7 cells were more prone to cytotoxic effects of MTX-GO/AgNPs compared to folate receptor-negative HepG2 cells. Folic acid analog MTX interacts with folate receptors expressed in MCF-7 cells, improving cellular uptake and subsequent anticancer effects of the system. Importantly, AgNPs enhanced the total ROS production within the treated cells leading to improve cellular apoptosis, as evidenced by western blot. Moreover, near infrared (NIR)-induced photothermal effects of GO improved the anticancer activity of the system. Therefore, the combinational therapy system MTX-GO/AgNPs can be potentially applied for effective folate receptor-targeted treatment of cancers.


Assuntos
Antineoplásicos/farmacologia , Grafite/farmacologia , Nanopartículas Metálicas/química , Metotrexato/farmacologia , Óxidos/farmacologia , Prata/farmacologia , Antineoplásicos/síntese química , Antineoplásicos/química , Apoptose/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Relação Dose-Resposta a Droga , Ensaios de Seleção de Medicamentos Antitumorais , Transportadores de Ácido Fólico/antagonistas & inibidores , Transportadores de Ácido Fólico/metabolismo , Grafite/química , Células Hep G2 , Humanos , Células MCF-7 , Metotrexato/química , Estrutura Molecular , Óxidos/química , Tamanho da Partícula , Espécies Reativas de Oxigênio/metabolismo , Prata/química , Relação Estrutura-Atividade , Propriedades de Superfície
12.
Nanotechnology ; 28(7): 075205, 2017 Feb 17.
Artigo em Inglês | MEDLINE | ID: mdl-28094242

RESUMO

Wrinkle-free graphene was used to form the source-drain electrodes in thin film transistors based on a zinc tin oxide (ZTO) semiconductor. A 10 nm thick titanium adhesion layer was applied prior to transferring a conductive graphene film on top of it by chemical detachment. The formation of an interlayer oxide between titanium and graphene allows the achievement of uniform surface roughness over the entire substrate area. The resulting devices were thermally treated in ambient air, and a substantial decrease in field effect mobility is observed with increasing annealing temperature. The increase in electrical resistivity of the graphene film at higher annealing temperatures may have some influence, however the growth of the oxide interlayer at the ZTO/Ti boundary is suggested to be most influential, thereby inducing relatively high contact resistance.

13.
Heart Vessels ; 32(2): 126-133, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27255644

RESUMO

Hyponatremia in the early phase of acute myocardial infarction (AMI) is a well-known predictor of poor prognosis. However, little is known about the clinical implication of sodium levels at discharge in hospital survivors after AMI. The study included 1290 consecutive patients (64 ± 12 years; 877 men) who survived the index hospitalization after AMI. We determined the 12-month mortality rates of these patients. Patients who died during the 12-month follow-up had lower sodium levels at discharge than those who had survived (137 ± 6 vs. 139 ± 4 mmol/L; P < 0.014). Hyponatremia at discharge, defined as a serum sodium level ≤135 mmol/L, was present in 210 patients (16.3 %). In the Cox-proportional hazard model, hyponatremia at discharge (hazard ratio, 2.264; 95 % confidence interval, 1.119-4.579; P = 0.023) was an independent predictor of 12-month mortality. Moreover, hyponatremia at discharge had an incremental prognostic value over conventional risk factors (χ 2 = 7, P = 0.007), and conventional risk factors and log N-terminal Pro-B-type natriuretic peptide combined (χ 2 = 5, P = 0.021). In the subgroup analysis, the 12-month mortality of patients with hyponatremia at discharge was significantly higher than in those without, irrespective of age, Killip class, left ventricular ejection fraction, percutaneous coronary intervention at index hospitalization, and prescription of diuretics at discharge. Hyponatremia at discharge is an independent predictor of 12-month mortality in hospital survivors after AMI.


Assuntos
Hiponatremia/epidemiologia , Infarto do Miocárdio/mortalidade , Infarto do Miocárdio/terapia , Alta do Paciente , Idoso , Idoso de 80 Anos ou mais , Diuréticos/uso terapêutico , Feminino , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Peptídeo Natriurético Encefálico/sangue , Fragmentos de Peptídeos/sangue , Intervenção Coronária Percutânea , Prognóstico , Modelos de Riscos Proporcionais , Curva ROC , Sistema de Registros , República da Coreia , Fatores de Risco , Volume Sistólico , Fatores de Tempo , Função Ventricular Esquerda
14.
J Prev Med Public Health ; 49(6): 376-385, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27951630

RESUMO

OBJECTIVES: This study was conducted to investigate the relationships among job stress, job satisfaction, and mental health in marine officers. METHODS: The researchers gathered data on marine officers working at a harbor in Chungcheong Province, South Korea, using a self-reported questionnaire. Mental health was measured by the Symptom Checklist-90-Revision (SCL-90-R), and general characteristics including socioeconomic factors, job stress, and job satisfaction were measured by structured questionnaires. Multiple regression analysis was performed to investigate the relationships among job stress, job satisfaction, and mental health status according to the symptom dimensions of the SCL-90-R. RESULTS: Among the marine officers, obsessive-compulsive behavior, depression, and somatization were the most problematic symptoms. Those who reported poor health, low job satisfaction, and high job stress had a higher prevalence of psychoticism, somatization, depression, anxiety, and phobic anxiety. CONCLUSIONS: An occupational health system should be introduced that would regularly check the mental health of marine officers in charge of ships and sailors, in order to help reduce their stress levels, enhance their job satisfaction, and thereby improve their mental health.


Assuntos
Satisfação no Emprego , Estresse Psicológico , Adulto , Idoso , Ansiedade , Depressão/diagnóstico , Depressão/epidemiologia , Humanos , Masculino , Saúde Mental , Pessoa de Meia-Idade , Transtorno Obsessivo-Compulsivo/diagnóstico , Transtorno Obsessivo-Compulsivo/epidemiologia , Análise de Regressão , Autorrelato , Fatores Socioeconômicos , Transtornos Somatoformes/diagnóstico , Transtornos Somatoformes/epidemiologia , Inquéritos e Questionários
15.
Front Oncol ; 6: 81, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27064712

RESUMO

The pretreatment neutrophil/lymphocyte ratio (NLR), derived from differential white blood cell counts, has been previously associated with poor prognosis in breast cancer. Little data exist, however, concerning this association in Black patients, who are known to have lower neutrophil counts than other racial groups. We conducted a retrospective cohort study of 236 Black and 225 non-Hispanic White breast cancer patients treated at a single institution. Neutrophil and lymphocyte counts were obtained from electronic medical records. Univariate and multivariate Cox regression models were used to determine hazard ratios (HRs) and 95% confidence intervals (95% CIs) of all-cause mortality and breast cancer-specific mortality in relation to pretreatment NLR. Overall, there were no associations between an elevated pretreatment NLR (NLR ≥3.7) and all-cause or breast cancer-specific mortality. Among patients without metastasis at the time of diagnosis, an elevated pretreatment NLR was independently associated with all-cause mortality, with a multivariable HR of 2.31 (95% CI: 1.10-4.86). Black patients had significantly lower NLR values than White patients, but there was no evidence suggesting racial heterogeneity of the prognostic utility of NLR. Pretreatment NLR was an independent predictor of all-cause mortality but not breast cancer-specific mortality in non-metastatic breast cancer patients.

16.
Int J Clin Pharm ; 37(6): 1228-34, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26364195

RESUMO

BACKGROUND: Tenofovir disoproxil fumarate (TDF) has demonstrated potent antiviral activity against hepatitis B virus (HBV) in clinical trials. Although its efficacy has been demonstrated in Caucasian populations, TDF has not previously been studied in Korean patients who present the predominance of HBV genotype C and of vertical or perinatal transmission. OBJECTIVE: The aim of this study was to evaluate the efficacy of TDF in Korean chronic hepatitis B (CHB) patients in real-life practice, and to determine the clinical variables that contribute to virologic response. SETTING: Large academic medical center in Korea. METHOD: We retrospectively investigated the efficacy of TDF treatment for more than 6 months in 151 nucleos(t)ide-naïve CHB patients. MAIN OUTCOME MEASURE: The primary endpoint was a virologic response (VR), defined as an HBV DNA level of <12 IU/mL. Secondary endpoints were rates of alanine aminotransaminase (ALT) normalization, hepatitis B e antigen (HBeAg) seroconversion, virologic breakthrough, and safety. RESULTS: All patients were the genotype C2. The median duration of TDF treatment was 13 months (range 7-18 months). Ninety-two (61.0 %) patients were HBeAg positive. The mean pre-treatment HBV DNA level was 6.34 ± 1.42 log10 IU/mL. Among the 131 patients with elevated ALT levels at baseline, 128 (97.7 %) patients achieved ALT normalization during TDF treatment. VR was achieved in 97 (64.2 %) patients. The cumulative rates of VR at 6, 9, 12, and 18 months were 47.0, 59.4, 67.9, and 69.3 %, respectively. Among the 92 HBeAg-positive patients, 14 (15.2 %) patients achieved HBeAg seroconversion. In multivariate analysis, absolute HBV DNA levels at baseline (P < 0.001; OR 0.529; 95 % CI 0.560-0.744) and HBeAg positivity (P = 0.015; OR 0.731; 95 % CI 0.615-0.869) were significantly associated with VR. Virologic breakthrough was observed in four patients. These four patients had poor adherence to TDF. Most of the adverse events were mild in severity. No significant changes were observed in serum creatinine and phosphorus levels. CONCLUSIONS: TDF was effective and well tolerated in Korean genotype C CHB patients in real life practice, consistent with larger registration trials. The absolute HBV DNA levels at baseline and HBeAg positivity were significantly associated with VR.


Assuntos
Antivirais/uso terapêutico , Hepatite B Crônica/tratamento farmacológico , Tenofovir/uso terapêutico , Centros Médicos Acadêmicos , Adulto , Alanina Transaminase/sangue , Antivirais/efeitos adversos , Grupo com Ancestrais do Continente Asiático , DNA Viral , Feminino , Genótipo , Antígenos E da Hepatite B/sangue , Hepatite B Crônica/etnologia , Hepatite B Crônica/genética , Humanos , Masculino , Pessoa de Meia-Idade , República da Coreia , Estudos Retrospectivos , Tenofovir/efeitos adversos , Carga Viral
17.
Nutr Res Pract ; 9(4): 370-8, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26244075

RESUMO

BACKGROUND/OBJECTIVES: Athletes generally desire changes in body composition in order to enhance their athletic performance. Often, athletes will practice chronic energy restrictions to attain body composition changes, altering their energy needs. Prediction of resting metabolic rates (RMR) is important in helping to determine an athlete's energy expenditure. This study compared measured RMR of athletic and non-athletic adolescents with predicted RMR from commonly used prediction equations to identify the most accurate equation applicable for adolescent athletes. SUBJECTS/METHODS: A total of 50 athletes (mean age of 16.6 ± 1.0 years, 30 males and 20 females) and 50 non-athletes (mean age of 16.5 ± 0.5 years, 30 males and 20 females) were enrolled in the study. The RMR of subjects was measured using indirect calorimetry. The accuracy of 11 RMR prediction equations was evaluated for bias, Pearson's correlation coefficient, and Bland-Altman analysis. RESULTS: Until more accurate prediction equations are developed, our findings recommend using the formulas by Cunningham (-29.8 kcal/day, limits of agreement -318.7 and +259.1 kcal/day) and Park (-0.842 kcal/day, limits of agreement -198.9 and +196.9 kcal/day) for prediction of RMR when studying male adolescent athletes. Among the new prediction formulas reviewed, the formula included in the fat-free mass as a variable [RMR = 730.4 + 15 × fat-free mass] is paramount when examining athletes. CONCLUSIONS: The RMR prediction equation developed in this study is better in assessing the resting metabolic rate of Korean athletic adolescents.

18.
J Cardiovasc Ultrasound ; 23(2): 78-85, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26140149

RESUMO

BACKGROUND: It is not well known about the implication of left ventricular (LV) strain as a predictor for mortality in patients with chronic aortic regurgitation (AR). The purpose of this study was to investigate whether global longitudinal strain measured by two-dimensional speckle-tracking echocardiography could predict long-term outcome in patients with chronic AR. METHODS: This is a single center non-randomized retrospective observational study. The patients with chronic AR from January 2002 to December 2012 were retrospectively enrolled. Following patients were excluded; combined other significant valvular disease, previous heart surgery, aortic disease, congenital heart disease, acute AR and young age under 18 years old. Finally, 60 patients were analyzed and the LV global strain rate was measured on apical four chamber image (GS-4CH). RESULTS: During 64 months follow-up duration, 16 patients (26.7%) were deceased and 38 patients (63.3%) underwent aortic valve replacement (AVR). Deceased group was older (69 years old vs. 51 years old, p < 0.001) and had lower longitudinal strain (-12.05 ± 3.72% vs. -15.66 ± 4.35%, p = 0.005). Kaplan-Meier survival curve stratified by GS-4CH showed a trend of different event rate (log rank p = 0.001). On multivariate analysis by cox proportional hazard model adjusting for age, sex, body surface area, history of atrial fibrillation, blood urea nitrogen, LV dilatation, LV ejection fraction and AVR, decreased GS-4CH proved to be an independent predictor of mortality in patients with chronic AR (hazard ratio 1.313, 95% confidence interval 1.010-1.706, p = 0.042). CONCLUSION: GS-4CH may be a useful predictor of mortality in patient with chronic AR.

19.
J Cardiovasc Ultrasound ; 23(2): 100-2, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26140152

RESUMO

Cardiac involvement is a major cause of morbidity and mortality in hypereosinophilic syndrome (HES). It is classified into 3 stages by the degree of eosinophils-mediated heart injury; acute necrotic stage, thrombotic stage, and fibrotic stage. Nonetheless, definitive evidence that each patient passes sequentially through these stages is lacking. We present a case of 48-year-old male patient with dyspnea and peripheral edema who underwent valve replacement surgery due to severe mitral regurgitation. After the valve replacement, HES with cardiac involvement in the thrombotic stage was diagnosed. In the follow-up study, the patient progressed into fibrotic stage of HES.

20.
J Gastroenterol Hepatol ; 30(10): 1514-21, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25973716

RESUMO

BACKGROUND AND AIM: In the past decade, many chronic hepatitis B (CHB) patients have undergone sequential treatment with lamivudine (LAM), adefovir (ADV), and entecavir (ETV) to manage antiviral resistance or insufficient suppression of HBV-DNA. Very limited data are available on the efficacy of tenofovir (TDF) rescue regimens in patients with multidrug resistance (MDR). METHODS: We investigated the antiviral efficacy of TDF/LAM combination therapy versus TDF/ETV combination therapy in 52 patients who failed three previous antiviral therapies. RESULTS: The study subjects were treated with TDF/LAM combination therapy (n = 25) or TDF/ETV combination therapy (n = 27) for more than six months. Virologic response (VR) occurred in 39 (75%) patients (19 patients belonged to the TDF/LAM group and 20 patients belonged to the TDF/ETV group). The VR rates were not different between the TDF/LAM and TDF/ETV groups (56.0% vs 51.9% at month 12, and 72.0% vs 78.8% at month 18; log rank P = 0.515). In addition, treatment efficacy of TDF/LAM combination or TDF/ETV combination was not statistically different according to types of MDR. In multivariate analysis, absolute HBV-DNA level at the start of TDF rescue treatment (P < 0.001; OR, 0.452; 95% CI, 0.306-0.666) was only significantly associated with VR. CONCLUSIONS: TDF/ETV combination therapy was not associated with higher rate of VR compared with TDF/LAM combination therapy in MDR CHB patients. These results raise the suspicion about the superiority of the combination therapy over TDF monotherapy. The lower HBV-DNA levels at the start of TDF-based rescue therapy were associated with higher VR.


Assuntos
Antivirais/administração & dosagem , Hepatite B Crônica/tratamento farmacológico , Tenofovir/administração & dosagem , Adenina/análogos & derivados , Adulto , DNA Viral/sangue , Resistência a Múltiplos Medicamentos , Quimioterapia Combinada , Feminino , Guanina/administração & dosagem , Guanina/análogos & derivados , Vírus da Hepatite B/genética , Hepatite B Crônica/virologia , Humanos , Lamivudina/administração & dosagem , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Organofosfonatos , Falha de Tratamento
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