Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 75
Filtrar
1.
J Environ Manage ; 288: 112400, 2021 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-33823436

RESUMO

Over the past century, the decline in biodiversity due to climate change and habitat loss has become unprecedentedly serious. Multiple drivers, including climate change, land-use/cover change, and qualitative change in habitat need to be considered in an integrated approach, which has rarely been taken, to create an effective conservation strategy. The purpose of this study is to quantitatively evaluate and map the combined impacts of those multiple drivers on biodiversity in the Republic of Korea (ROK). To this end, biodiversity persistence (BP) was simulated by employing generalized dissimilarity modeling with estimates of habitat conditions. Habitat Condition Index was newly developed based on national survey datasets to represent the changes in habitat quality according to the land cover changes and forest management, especially after the ROK's National Reforestation Programme. The changes in habitat conditions were simulated for a period ranging from the 1960s to the 2010s; additionally, future (2050s) spatial scenarios were constructed. By focusing on the changes in forest habitat quality along with climate and land use, this study quantitatively and spatially analyzed the changes in BP over time and presented the effects of reforestation and forest management. The results revealed that continuous forest management had a positive impact on BP by offsetting the negative effects of past urbanization. Improvements in forest habitat quality also can effectively reduce the negative impacts of climate change. This quantitative analysis of successful forest restoration in Korea proved that economic development and urbanization could be in parallel with biodiversity enhancement. Nevertheless, current forest management practices were found to be insufficient in fully offsetting the decline in future BP caused by climate change. This indicates that there is a need for additional measures along with mitigation of climate change to maintain the current biodiversity level.

2.
Orthod Craniofac Res ; 24 Suppl 1: 31-38, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33652500

RESUMO

INTRODUCTION: The purpose of this study was to evaluate the long-term position of erupted third molars after maxillary total arch distalization using modified C-palatal plates (MCPPs) in adolescents and to identify factors associated with these positions. SETTING AND SAMPLE POPULATION: Sixty-two third molars (male: 20, female: 42) in Class II patients treated with MCPPs and thirty-nine teeth for the Control group (male: 22, female: 17). MATERIALS AND METHODS: Samples were analyzed using panoramic radiographs taken initially (T0), after treatment (T1) and after >3 years retention (T2). Third molars were classified as downward (Group A, N = 31; males: 12, females: 19) and upward (Group B, N = 31; males: 8, females: 23) based on their vertical position after treatment. Analysis of variance and multiple logistic regression analysis were performed. RESULTS: The vertical position of the third molars of Group A, Group B, and the Control showed a 2.2, 3.5 and 2.7 mm downward movement at T2. However, there was no difference in the amount of third molar eruption among the groups. Regarding factors affecting the vertical distance of the third molar, Age, C8-OP, ∠8-OP and D7-T at the initial affected vertical position of the third molars after molar distalization (P < .05). CONCLUSIONS: Group A and B showed no difference in the third molar eruption during retention after total arch distalization. This study suggests that it might be unnecessary to extract the developing third molar before molar distalization in Class II adolescents.


Assuntos
Má Oclusão de Angle Classe II , Dente Serotino , Adolescente , Cefalometria , Feminino , Humanos , Masculino , Maxila/diagnóstico por imagem , Dente Molar/diagnóstico por imagem , Dente Serotino/diagnóstico por imagem , Dente Serotino/cirurgia , Técnicas de Movimentação Dentária
3.
PLoS One ; 16(3): e0248020, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33651848

RESUMO

Osteoporosis is the most common disease of the musculoskeletal system in old age. Therefore, research on osteoporosis risk factors is actively being conducted. However, whether socioeconomic inequality is associated with the prevalence and diagnosis experience of osteoporosis remains largely unexplored. This study aims to investigate whether socioeconomic inequality can be a risk factor for osteoporosis in postmenopausal women. Cross-sectional data of 1,477 postmenopausal women aged over 50 obtained from the Korea National Health and Nutrition Examination Survey V-2 were analyzed. Univariate analyses were performed to calculate the prevalence of osteoporosis and the rate of osteoporosis diagnosis experience according to the risk factor categories. Multivariate logistic regression analysis was performed to identify the independent variables' associations with osteoporosis prevalence and diagnosis experience. The prevalence of osteoporosis was 34.8%, while the diagnosis experience rate was 22.1%. The higher the age, the higher the probability of osteoporosis presence and diagnosis experience. The lowest household income level was associated with a 1.63 times higher risk of osteoporosis. On the contrary, this factor was not significant for diagnosis experience. These results were similar for the 50-59 and 60-69 age groups. Among postmenopausal women, those who are older and have low socioeconomic levels are at a high risk of developing osteoporosis. Moreover, the lower the socioeconomic level, the lower the awareness of osteoporosis. Therefore, there is a need to develop more proactive preventive measures in postmenopausal women with low socioeconomic levels.

4.
Viruses ; 13(3)2021 02 27.
Artigo em Inglês | MEDLINE | ID: mdl-33673635

RESUMO

Wild aquatic birds, a natural reservoir of avian influenza viruses (AIVs), transmit AIVs to poultry farms, causing huge economic losses. Therefore, the prevalence and genetic characteristics of AIVs isolated from wild birds in South Korea from October 2019 to March 2020 were investigated and analyzed. Fresh avian fecal samples (3256) were collected by active monitoring of 11 wild bird habitats. Twenty-eight AIVs were isolated. Seven HA and eight NA subtypes were identified. All AIV hosts were Anseriformes species. The HA cleavage site of 20 representative AIVs was encoded by non-multi-basic amino acid sequences. Phylogenetic analysis of the eight segment genes of the AIVs showed that most genes clustered within the Eurasian lineage. However, the HA gene of H10 viruses and NS gene of four viruses clustered within the American lineage, indicating intercontinental reassortment of AIVs. Representative viruses likely to infect mammals were selected and evaluated for pathogenicity in mice. JB21-58 (H5N3), JB42-93 (H9N2), and JB32-81 (H11N2) were isolated from the lungs, but JB31-69 (H11N9) was not isolated from the lungs until the end of the experiment at 14 dpi. None of infected mice showed clinical sign and histopathological change in the lung. In addition, viral antigens were not detected in lungs of all mice at 14 dpi. These data suggest that LPAIVs derived from wild birds are unlikely to be transmitted to mammals. However, because LPAIVs can reportedly infect mammals, including humans, continuous surveillance and monitoring of AIVs are necessary, despite their low pathogenicity.

5.
Am J Orthod Dentofacial Orthop ; 159(2): 234-245, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33546828

RESUMO

Autotransplantation of a mature premolar in adults can be a treatment of choice for tooth replacement when combined with well-planned orthodontic treatment. This case report describes the successful treatment of a 39-year-old patient with severe crowding and a hopelessly fractured tooth on the maxillary left side. Maxillary dental crowding was relieved by extraction of a premolar on the right side, and this extracted tooth was autotransplanted to replace the fractured tooth. A mandibular incisor was extracted to correct anterior crossbite. The total treatment period was 20 months. The treatment results showed a good long-term prognosis after transplantation of a mature premolar with normal surrounding alveolar bone level for over 6 years of follow-up. Occlusion and periodontal health were excellent in the long term.


Assuntos
Fraturas dos Dentes , Adulto , Dente Pré-Molar/cirurgia , Humanos , Incisivo , Mandíbula , Maxila , Fraturas dos Dentes/diagnóstico por imagem , Fraturas dos Dentes/cirurgia , Transplante Autólogo
6.
Angle Orthod ; 91(1): 22-29, 2021 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-33339047

RESUMO

OBJECTIVES: To compare the dental and skeletal treatment effects after total arch distalization using modified C-palatal plates (MCPPs) on adolescent patients with hypo- and hyperdivergent Class II malocclusion. MATERIALS AND METHODS: The study group included 40 patients with Class II malocclusion (18 boys and 22 girls, mean age = 12.2 ± 1.4 years) treated with MCPPs. Fixed orthodontic treatment started with the distalizing process in both groups. Participants were divided into hypo- or hyperdivergent groups based on their pretreatment Frankfort mandibular plane angle (FMA) ≤22° or ≥28°, respectively. Pre- and posttreatment lateral cephalograms were digitized, and 23 variables were measured and compared for both groups using paired and independent t-tests. RESULTS: The hyper- and hypodivergent groups showed 2.7 mm and 4.3 mm of first molar crown distalizing movement, respectively (P < .001). The hypodivergent group had a slight 2.2° crown distal tipping of first molars compared with 0.3° in the hyperdivergent group. After distalization, the FMA increased 3.1° and 0.3°, in the hypodivergent and hyperdivergent groups, respectively (P < .001). SNA decreased in the hypodivergent group, while other skeletal variables presented no statistically significant differences in the changes between the groups. CONCLUSIONS: The hypodivergent group showed more distal and tipping movement of the maxillary first molar and increased FMA than the hyperdivergent group. Therefore, clinicians must consider vertical facial types when distalizing molars using MCPPs in Class II nonextraction treatment.


Assuntos
Má Oclusão de Angle Classe II , Desenho de Aparelho Ortodôntico , Adolescente , Cefalometria , Feminino , Humanos , Masculino , Má Oclusão de Angle Classe II/diagnóstico por imagem , Má Oclusão de Angle Classe II/terapia , Maxila , Técnicas de Movimentação Dentária
7.
Angle Orthod ; 2020 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-33289781

RESUMO

OBJECTIVES: To compare the dental and skeletal treatment effects after total arch distalization using modified C-palatal plates (MCPPs) on adolescent patients with hypo- and hyperdivergent Class II malocclusion. MATERIALS AND METHODS: The study group included 40 patients with Class II malocclusion (18 boys and 22 girls, mean age = 12.2 ± 1.4 years) treated with MCPPs. Fixed orthodontic treatment started with the distalizing process in both groups. Participants were divided into hypo- or hyperdivergent groups based on their pretreatment Frankfort mandibular plane angle (FMA) ≤22° or ≥28°, respectively. Pre- and posttreatment lateral cephalograms were digitized, and 23 variables were measured and compared for both groups using paired and independent t-tests. RESULTS: The hyper- and hypodivergent groups showed 2.7 mm and 4.3 mm of first molar crown distalizing movement, respectively (P < .001). The hypodivergent group had a slight 2.2° crown distal tipping of first molars compared with 0.3° in the hyperdivergent group. After distalization, the FMA increased 3.1° and 0.3°, in the hypodivergent and hyperdivergent groups, respectively (P < .001). SNA decreased in the hypodivergent group, while other skeletal variables presented no statistically significant differences in the changes between the groups. CONCLUSIONS: The hypodivergent group showed more distal and tipping movement of the maxillary first molar and increased FMA than the hyperdivergent group. Therefore, clinicians must consider vertical facial types when distalizing molars using MCPPs in Class II nonextraction treatment.

8.
Angle Orthod ; 90(4): 556-563, 2020 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-33378503

RESUMO

OBJECTIVES: To investigate the associations between nasal airway volume and the presence and severity of obstructive sleep apnea (OSA) in adults. MATERIALS AND METHODS: The medical records of adult patients who visited the sleep clinic at University Hospital between June 2013 and April 2017 and underwent overnight polysomnography for the diagnosis of obstructive sleep apnea were reviewed retrospectively. Using computed tomography, the volumes of the nasal airways and maxillary sinuses were measured, and associations with the presence and severity of OSA were analyzed while controlling for the effects of possible confounders such as lateral cephalometric variables, maxillary widths, tongue/hyoid position, and soft palate dimensions. RESULTS: Comparison between normal subjects and patients with OSA revealed that the latter had decreased ratios of maxillary sinus volume to whole nasal airway volume (P = .029) than normal subjects. OSA severity was greater in those with inferior positions of the hyoid (P = .010), in older patients (P = .011), and in those with high body mass index (P = .001). The volume of the total nasal airway or maxillary sinuses were not associated with OSA severity. CONCLUSIONS: A decreased ratio of maxillary sinus volume to whole nasal airway volume is associated with adult OSA. However, OSA severity is not associated with either maxillary sinus volume or whole nasal airway volume.


Assuntos
Seio Maxilar , Apneia Obstrutiva do Sono , Adulto , Idoso , Cefalometria , Humanos , Seio Maxilar/diagnóstico por imagem , Polissonografia , Estudos Retrospectivos , Apneia Obstrutiva do Sono/diagnóstico por imagem
9.
Angle Orthod ; 90(6): 890, 2020 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-33126258
10.
Int J Mol Sci ; 21(17)2020 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-32883029

RESUMO

YKL-40, also known as chitinase-3-like 1 (CHI3L1), is a glycoprotein that is expressed and secreted by various cell types, including cancers and macrophages. Due to its implications for and upregulation in a variety of diseases, including inflammatory conditions, fibrotic disorders, and tumor growth, YKL-40 has been considered as a significant therapeutic biomarker. Here, we used a phage display to develop novel monoclonal antibodies (mAbs) targeting human YKL-40 (hYKL-40). Human synthetic antibody phage display libraries were panned against a recombinant hYKL-40 protein, yielding seven unique Fabs (Antigen-binding fragment), of which two Fabs (H1 and H2) were non-aggregating and thermally stable (75.5 °C and 76.5 °C, respectively) and had high apparent affinities (KD = 2.3 nM and 4.0 nM, respectively). Reformatting the Fabs into IgGs (Immunoglobulin Gs) increased their apparent affinities (notably, for H1 and H2, KD = 0.5 nM and 0.3 nM, respectively), presumably due to the effects of avidity, with little change to their non-aggregation property. The six anti-hYKL-40 IgGs were analyzed using a trans-well migration assay in vitro, revealing that three clones (H1, H2, and H4) were notably effective in reducing cell migration from both A549 and H460 lung cancer cell lines. The three clones were further analyzed in an in vivo animal test that assessed their anti-cancer activities, demonstrating that the tumor area and the number of tumor nodules were significantly reduced in the lung tissues treated with H1 (IgG). Given its high affinity and desirable properties, we expect that the H1 anti-hYKL-40 mAb will be a suitable candidate for developing anti-cancer therapeutics.

11.
Comput Methods Programs Biomed ; 194: 105513, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32403052

RESUMO

BACKGROUND AND OBJECTIVE: An accurate lateral cephalometric analysis is vital in orthodontic diagnosis. Identification of anatomic landmarks on lateral cephalograms is tedious, and errors may occur depending on the doctor's experience. Several attempts have been made to reduce this time-consuming process by automating the process through machine learning; however, they only dealt with a small amount of data from one institute. This study aims to develop a fully automated cephalometric analysis method using deep learning and a corresponding web-based application that can be used without high-specification hardware. METHODS: We built our own dataset comprising 2,075 lateral cephalograms and ground truth positions of 23 landmarks from two institutes and trained a two-stage automated algorithm with a stacked hourglass deep learning model specialized for detecting landmarks in images. Additionally, a web-based application with the proposed algorithm for fully automated cephalometric analysis was developed for better accessibility regardless of the user's computer hardware, which is essential for a deep learning-based method. RESULTS: The algorithm was evaluated with datasets from various devices and institutes, including a widely used open dataset and achieved 1.37 ± 1.79 mm of point-to-point errors with ground truth positions for 23 cephalometric landmarks. Based on the predicted positions, anatomical types of the subjects were automatically classified and compared with the ground truth, and the automated algorithm achieved a successful classification rate of 88.43%. CONCLUSIONS: We expect that this fully automated cephalometric analysis algorithm and the web-based application can be widely used in various medical environments to save time and effort for manual marking and diagnosis.

12.
Food Sci Nutr ; 8(4): 1898-1903, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32328255

RESUMO

A chronic inflammatory environment facilitates tumor growth and proliferation. Fruits and vegetables are important sources of anthocyanins, polyphenols, and other biologically active substances that can favorably affect the pathogenesis of cancer. The objective of the study was to investigate the anti-inflammatory effects of Red Chinese cabbage (RC) and mixture of commercial Red Chinese cabbage leaves and Aronia fruits (ARC) in LPS-stimulated RAW 264.7 cells. The RAW 264.7 cells were cultured and measured the cytotoxicity by using an MTT assay. The inflammatory markers, such as nitrite, IL-6, and TNF-alpha expression, were evaluated using ELISA, and protein expression of inflammatory markers like iNOS and COX-2 was analyzed using Western blot. MTT assays showed that pretreatment of RAW 264.7 cells with RC and ARC did not change cell growth or cytotoxicity. We also found that ARC extracts reduced inflammation-related biomarker (TNF-a, IL-6, and NO) production and gene expression (iNOS, COX-2). Our results suggested that ARC has good anti-inflammatory properties compared with RC that maybe used as potential nutrients for treating inflammatory diseases.

13.
Angle Orthod ; 2020 Feb 24.
Artigo em Inglês | MEDLINE | ID: mdl-32091265

RESUMO

OBJECTIVES: To investigate the associations between nasal airway volume and the presence and severity of obstructive sleep apnea (OSA) in adults. MATERIALS AND METHODS: The medical records of adult patients who visited the sleep clinic at University Hospital between June 2013 and April 2017 and underwent overnight polysomnography for the diagnosis of obstructive sleep apnea were reviewed retrospectively. Using computed tomography, the volumes of the nasal airways and maxillary sinuses were measured, and associations with the presence and severity of OSA were analyzed while controlling for the effects of possible confounders such as lateral cephalometric variables, maxillary widths, tongue/hyoid position, and soft palate dimensions. RESULTS: Comparison between normal subjects and patients with OSA revealed that the latter had decreased ratios of maxillary sinus volume to whole nasal airway volume (P = .029) than normal subjects. OSA severity was greater in those with inferior positions of the hyoid (P = .010), in older patients (P = .011), and in those with high body mass index (P = .001). The volume of the total nasal airway or maxillary sinuses were not associated with OSA severity. CONCLUSIONS: A decreased ratio of maxillary sinus volume to whole nasal airway volume is associated with adult OSA. However, OSA severity is not associated with either maxillary sinus volume or whole nasal airway volume.

14.
Angle Orthod ; 90(2): 181-186, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31769700

RESUMO

OBJECTIVES: To investigate factors associated with spontaneous mesialization of impacted third molars after second molar protraction to close the space caused by a missing mandibular first molar (L-6) or retained deciduous mandibular second molars with a missing succedaneous premolar (L-E). MATERIALS AND METHODS: Panoramic radiographs of patients treated with mandibular second molar protraction to close the space due to missing L-6 or L-E (14 males, 36 females, mean age = 18.6 ± 4.4 years) were analyzed before treatment (T1) and after second molar protraction (T2). Factors associated with the amount of third molar mesialization were investigated using regression analyses. RESULTS: Mandibular second molars were protracted by 5.1 ± 2.1 mm and 5.8 ± 2.7 mm, measured at the crown and root furcation, respectively. After second molar protraction, third molars showed spontaneous mesialization by 4.3 ± 1.6 mm and 3.8 ± 2.6 mm, measured at the crown and root furcation, respectively. Nolla's stage of the third molar at T1 (B = 0.20, P = .026) and second molar protraction time (B = 0.04, P = .042) were significantly associated with the amount of third molar mesialization. CONCLUSIONS: Greater third molar mesialization was observed when Nolla's stage of the third molar was higher before treatment and when the second molar protraction time was longer.


Assuntos
Mandíbula , Dente Serotino , Dente Impactado , Adolescente , Adulto , Feminino , Humanos , Masculino , Mandíbula/diagnóstico por imagem , Dente Molar , Dente Serotino/diagnóstico por imagem , Radiografia Panorâmica , Adulto Jovem
15.
J Med Syst ; 44(1): 18, 2019 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-31823091

RESUMO

This study investigates the feasibility of estimation of blood pressure (BP) using a single earlobe photoplethysmography (Ear PPG) during cardiopulmonary resuscitation (CPR). We have designed a system that carries out Ear PPG for estimation of BP. In particular, the BP signals are estimated according to a long short-term memory (LSTM) model using an Ear PPG. To investigate the proposed method, two statistical analyses were conducted for comparison between BP measured by the micromanometer-based gold standard method (BPMEAS) and the Ear PPG-based proposed method (BPEST) for swine cardiac model. First, Pearson's correlation analysis showed high positive correlations (r = 0.92, p < 0.01) between BPMEAS and BPEST. Second, the paired-samples t-test on the BP parameters (systolic and diastolic blood pressure) of the two methods indicated no significant differences (p > 0.05). Therefore, the proposed method has the potential for estimation of BP for CPR biofeedback based on LSTM using a single Ear PPG.


Assuntos
Inteligência Artificial , Determinação da Pressão Arterial/métodos , Reanimação Cardiopulmonar , Fotopletismografia/instrumentação , Biorretroalimentação Psicológica , Estudos de Viabilidade , Humanos
16.
Pilot Feasibility Stud ; 5: 123, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31720002

RESUMO

Background: Recruitment of a diverse participant pool to cancer clinical trials is an essential component of clinical research as it improves the generalizability of findings. Investigating and piloting novel recruitment strategies that take advantage of ubiquitous digital technologies has become an important component of facilitating broad recruitment and addressing inequities in clinical trial participation. Equitable and inclusive recruitment improves generalizability of clinical trial outcomes, benefiting patients, clinicians, and the research community. The increasing prevalence of online connectivity in the USA and use of the Internet as a resource for medical information provides an opportunity for digital recruitment strategies in cancer clinical trials. This study aims to measure the acceptability, preliminary estimates of efficacy, and feasibility of the Trial Library intervention, an Internet-based cancer clinical trial matching tool. This study will also examine the extent to which the Trial Library website, designed to address the linguistic and literacy needs of broader patient populations, influences patient-initiated conversations with physicians about clinical trial participation. Methods: This is a study protocol for a non-randomized, single-arm pilot study. This is a mixed methods study design that utilizes the statistical analysis of quantitative survey data and the qualitative analysis of interview data to assess the participant experience with the Trial Library intervention. This study will examine (1) acceptability as a measure of participant satisfaction with this intervention, (2) preliminary measure of efficacy as a measure of proportion of participants with documented clinical trial discussion in the electronic medical record, and (3) feasibility of the intervention as a measure of duration of clinical visit. Discussion: The principles that informed the design of the Trial Library intervention aim to be generalizable to clinical trials across many disease contexts. From the ground up, this intervention is built to be inclusive of the linguistic, literacy, and technological needs of underrepresented patient populations. This study will collect essential preliminary data prior to a multi-site randomized clinical trial of the Trial Library intervention. Trial registration: This study has received institutional approval from the Committee of Human Subjects Research at the University of California, San Francisco.

17.
PLoS One ; 14(10): e0223948, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31622405

RESUMO

Studies of voice recognition in biology suggest that long exposure may not satisfactorily represent the voice acquisition process. The current study proposes that humans can acquire a newly familiar voice from brief exposure to spontaneous speech, given a personally engaging context. Studies have shown that arousing and emotionally engaging experiences are more likely to be recorded and consolidated in memory. Yet it remains undemonstrated whether this advantage holds for voices. The present study examined the role of emotionally expressive context in the acquisition of voices following a single, 1-minute exposure by comparing recognition of voices experienced in engaging and neutral contexts at two retention intervals. Listeners were exposed to a series of emotionally nuanced and neutral videotaped narratives produced by performers, and tested on the recognition of excerpted voice samples, by indicating whether they had heard the voice before, immediately and after a one-week delay. Excerpts were voices from exposed videotaped narratives, but utilized verbal material taken from a second (nonexposed) narrative provided by the same performer. Overall, participants were consistently able to distinguish between voices that were exposed during the video session and voices that were not exposed. Voices experienced in emotional, engaging contexts were significantly better recognized than those in neutral ones both immediately and after a one-week delay. Our findings provide the first evidence that new voices can be acquired rapidly from one-time exposure and that nuanced context facilitates initially inducting new voices into a repertory of personally familiar voices in long-term memory. The results converge with neurological evidence to suggest that cerebral processes differ for familiar and unfamiliar voices.


Assuntos
Memória/fisiologia , Reconhecimento Fisiológico de Modelo/fisiologia , Voz/fisiologia , Adulto , Emoções , Feminino , Humanos , Masculino , Percepção da Fala , Gravação em Vídeo , Adulto Jovem
18.
Medicina (Kaunas) ; 55(9)2019 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-31484416

RESUMO

Background and objectives: This study investigated the morphology of the labial and palatal bony wall of the maxillary central and lateral incisors using cone-beam computed tomography (CBCT). The difference between males and females and the measurement between right and left sides were measured. Materials and Methods: Twenty participants, consisting of 11 females and 9 males having normal occlusion, were used for the analysis. The mean age was 21.9 ± 3.0 years. The thickness of the labial bony wall and palatal bony wall, perpendicular to the long axis of the root, were evaluated at 3 and 5 mm apical from the cemento-enamel junction (CEJ) and at the root apex. The available bony wall below the apex of the central and lateral incisors, and the angulation between the long axis of the tested tooth and outer surface of the labial bone were measured. Results: The mean labial bony wall thickness at the 3 and 5 mm apical from the CEJ were 1.1 ± 0.3 mm and 1.0 ± 0.4 mm for central incisors, respectively, as well as 1.2 ± 0.4 mm and 1.0 ± 0.4 mm for lateral incisors, respectively. The mean palatal bony wall thickness at 5 mm from the CEJ was above 2 mm in the central and lateral incisors. The percentage of labial bony wall thickness 2 mm or greater at the root apex in central incisors was higher than in lateral incisors (62.5% vs. 55.0%). The percentage of palatal bony wall thickness ≥2 mm at 3 mm apical from the CEJ in the central incisors was higher than in the lateral incisors (37.5% vs. 15.0%). The results on the left and right sides did not show statistically significant differences, except in the labial and palatal bony wall thickness at 3 mm from the CEJ in the lateral incisor. Generally, no significant differences were seen between males and females, but males had a significantly higher labial bony wall thickness at 3 and 5 mm from the CEJ in the central and lateral incisors when compared with females. Conclusions: This study showed that a majority of the cases of Korean participants had less than 2 mm of labial bony wall thickness at 3 and 5 mm apical from the CEJ at central and lateral incisors, and this should be kept in mind while performing dental practices, including tooth extraction or immediate implantation in anterior regions. Preoperative analysis using CBCT may be beneficial for establishing the treatment plan.


Assuntos
Perda do Osso Alveolar/classificação , Oclusão Dentária , Incisivo/patologia , Adolescente , Tomografia Computadorizada de Feixe Cônico/métodos , Feminino , Humanos , Masculino , Maxila/patologia , Adulto Jovem
19.
Antibodies (Basel) ; 8(3)2019 Jul 31.
Artigo em Inglês | MEDLINE | ID: mdl-31544848

RESUMO

Since its first report in the Middle East in 2012, the Middle East respiratory syndrome-coronavirus (MERS-CoV) has become a global concern due to the high morbidity and mortality of individuals infected with the virus. Although the majority of MERS-CoV cases have been reported in Saudi Arabia, the overall risk in areas outside the Middle East remains significant as inside Saudi Arabia. Additional pandemics of MERS-CoV are expected, and thus novel tools and reagents for therapy and diagnosis are urgently needed. Here, we used phage display to develop novel monoclonal antibodies (mAbs) that target MERS-CoV. A human Fab phage display library was panned against the S2 subunit of the MERS-CoV spike protein (MERS-S2P), yielding three unique Fabs (S2A3, S2A6, and S2D5). The Fabs had moderate apparent affinities (Half maximal effective concentration (EC50 = 123-421 nM) for MERS-S2P, showed no cross-reactivity to spike proteins from other CoVs, and were non-aggregating and thermostable (Tm = 61.5-80.4 °C). Reformatting the Fabs into IgGs (Immunoglobulin Gs) greatly increased their apparent affinities (KD = 0.17-1.2 nM), presumably due to the effects of avidity. These apparent affinities were notably higher than that of a previously reported anti-MERS-CoV S2 reference mAb (KD = 8.7 nM). Furthermore, two of the three mAbs (S2A3 and S2D5) bound only MERS-CoV (Erasmus Medical Center (EMC)) and not other CoVs, reflecting their high binding specificity. However, the mAbs lacked MERS-CoV neutralizing activity. Given their high affinity, specificity, and desirable stabilities, we anticipate that these anti-MERS-CoV mAbs would be suitable reagents for developing antibody-based diagnostics in laboratory or hospital settings for point-of-care testing.

20.
Am J Orthod Dentofacial Orthop ; 156(2): 178-185, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31375227

RESUMO

INTRODUCTION: This study aimed to identify significant factors affecting the spontaneous angular changes of impacted mandibular third molars as a result of second molar protraction. Temporary skeletal anchorage devices in the missing mandibular first molar (ML-6) or missing deciduous mandibular second molar (ML-E) with missing succedaneous premolar spaces provided traction. METHODS: Forty-one mandibular third molars of 34 patients (10 male and 24 female; mean age 18.3 ± 3.7 years) that erupted after second molar protraction were included in this study. They were classified into upright (U) and tilted (T) groups. Linear and angular measurements were performed at the time of treatment initiation (T1) and of ML-6 or ML-E space closure (T2). Regression analyses were used to identify significant factors related to third molar uprighting. RESULTS: Nolla stage (odds ratio [OR] 4.1), sex (OR 0.003 for male), third molar angulation at T1 (OR 1.1), missing tooth space (OR 0.006), rate of third molar eruption (OR 23.3), and rate of second molar protraction (OR 0.2) significantly affected third molar uprighting. Age, third molar angulation at T1, rate of third molar eruption, and rate of second molar protraction were significant factors for predicting third molar angulation at T2. CONCLUSIONS: Available space for third molar eruption before and after second molar protraction is not associated with uprighting of erupting third molars. Older patients whose third molars are in greater Nolla stage, are in a more upright position at T1, and have a greater eruption rate have a greater chance for third molar uprighting. Alternatively, an increase in second molar protraction rate results in mesial tipping of the third molars.


Assuntos
Má Oclusão/prevenção & controle , Má Oclusão/fisiopatologia , Mandíbula/fisiopatologia , Dente Serotino/fisiopatologia , Dente Impactado/fisiopatologia , Adolescente , Adulto , Pontos de Referência Anatômicos , Dente Pré-Molar , Feminino , Humanos , Masculino , Má Oclusão/diagnóstico por imagem , Mandíbula/anatomia & histologia , Mandíbula/diagnóstico por imagem , Dente Molar/anatomia & histologia , Dente Molar/diagnóstico por imagem , Dente Molar/fisiopatologia , Dente Serotino/anatomia & histologia , Dente Serotino/diagnóstico por imagem , Aparelhos Ortodônticos , Fechamento de Espaço Ortodôntico , Ortodontia Corretiva , Erupção Dentária , Dente Decíduo , Dente Impactado/complicações , Dente Impactado/diagnóstico por imagem , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...