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1.
Molecules ; 26(11)2021 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-34198892

RESUMO

This study investigated the antioxidant activity DPPH, ABTS, and Folin-Ciocalteu methods of betulin (compound 1) and its derivatives (compounds 2-11). Skin permeability and accumulation associated with compounds 1 and 8 were also examined. Identification of the obtained products (compound 2-11) and betulin isolated from plant material was based on the analysis of 1H- NMR and 13C-NMR spectra. The partition coefficient was calculated to determine the lipophilicity of all compounds. In the next stage, the penetration through pig skin and its accumulation in the skin were evaluated of ethanol vehicles containing compound 8 (at a concentration of 0.226 mmol/dm3), which was characterized by the highest antioxidant activity. For comparison, penetration studies of betulin itself were also carried out. Poor solubility and the bioavailability of pure compounds are major constraints in combination therapy. However, we observed that the ethanol vehicle was an enhancer of skin permeation for both the initial betulin and compound 8. The betulin 8 derivative showed increased permeability through biological membranes compared to the parent betulin. The paper presents the transformation of polycyclic compounds to produce novel derivatives with marked antioxidant activities and as valuable intermediates for the pharmaceutical industry. Moreover, the compounds contained in the vehicles, due to their mechanism of action, can have a beneficial effect on the balance between oxidants and antioxidants in the body, minimizing the effects of oxidative stress. The results of this work may contribute to knowledge regarding vehicles with antioxidant potential. The use of vehicles for this type of research is therefore justified.


Assuntos
Antioxidantes/farmacologia , Pele/química , Triterpenos/farmacologia , Animais , Antioxidantes/química , Antioxidantes/farmacocinética , Disponibilidade Biológica , Espectroscopia de Ressonância Magnética Nuclear de Carbono-13 , Estrutura Molecular , Espectroscopia de Prótons por Ressonância Magnética , Absorção Cutânea , Solubilidade , Suínos , Triterpenos/química , Triterpenos/farmacocinética
2.
Int J Mol Sci ; 22(12)2021 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-34200719

RESUMO

The potential of bacterial cellulose as a carrier for the transport of ibuprofen (a typical example of non-steroidal anti-inflammatory drugs) through the skin was investigated. Ibuprofen and its amino acid ester salts-loaded BC membranes were prepared through a simple methodology and characterized in terms of structure and morphology. Two salts of amino acid isopropyl esters were used in the research, namely L-valine isopropyl ester ibuprofenate ([ValOiPr][IBU]) and L-leucine isopropyl ester ibuprofenate ([LeuOiPr][IBU]). [LeuOiPr][IBU] is a new compound; therefore, it has been fully characterized and its identity confirmed. For all membranes obtained the surface morphology, tensile mechanical properties, active compound dissolution assays, and permeation and skin accumulation studies of API (active pharmaceutical ingredient) were determined. The obtained membranes were very homogeneous. In vitro diffusion studies with Franz cells were conducted using pig epidermal membranes, and showed that the incorporation of ibuprofen in BC membranes provided lower permeation rates to those obtained with amino acids ester salts of ibuprofen. This release profile together with the ease of application and the simple preparation and assembly of the drug-loaded membranes indicates the enormous potentialities of using BC membranes for transdermal application of ibuprofen in the form of amino acid ester salts.


Assuntos
Aminoácidos/química , Anti-Inflamatórios não Esteroides/farmacologia , Celulose/química , Ésteres/química , Ibuprofeno/farmacologia , Absorção Cutânea/efeitos dos fármacos , Pele/efeitos dos fármacos , Administração Cutânea , Animais , Anti-Inflamatórios não Esteroides/administração & dosagem , Anti-Inflamatórios não Esteroides/química , Bactérias/metabolismo , Sistemas de Liberação de Medicamentos , Ibuprofeno/administração & dosagem , Ibuprofeno/química , Suínos
3.
Int J Mol Sci ; 22(12)2021 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-34200927

RESUMO

Bacterial cellulose membranes (BCs) are becoming useful as a drug delivery system to the skin. However, there are very few reports on their application of plant substances to the skin. Komagataeibacter xylinus was used for the production of bacterial cellulose (BC). The BC containing 5% and 10% ethanolic extract of Epilobium angustifolium (FEE) (BC-5%FEE and BC-10%FEE, respectively) were prepared. Their mechanical, structural, and antioxidant properties, as well as phenolic acid content, were evaluated. The bioavailability of BC-FESs using mouse L929 fibroblasts as model cells was tested. Moreover, In Vitro penetration through the pigskin of the selected phenolic acids contained in FEE and their accumulation in the skin after topical application of BC-FEEs was examined. The BC-FEEs were characterized by antioxidant activity. The BC-5% FEE showed relatively low toxicity to healthy mouse fibroblasts. Gallic acid (GA), chlorogenic acid (ChA), 3,4-dihydroxybenzoic acid (3,4-DHB), 4-hydroxybenzoic acid (4-HB), 3-hydroxybenzoic acid (3-HB), and caffeic acid (CA) found in FEE were also identified in the membranes. After topical application of the membranes to the pigskin penetration of some phenolic acid and other antioxidants through the skin as well as their accumulation in the skin was observed. The bacterial cellulose membrane loaded by plant extract may be an interesting solution for topical antioxidant delivery to the skin.


Assuntos
Antioxidantes/administração & dosagem , Celulose/química , Epilobium/química , Fibroblastos/efeitos dos fármacos , Extratos Vegetais/administração & dosagem , Pele/efeitos dos fármacos , Administração Tópica , Animais , Bactérias/química , Fibroblastos/metabolismo , Camundongos , Pele/metabolismo , Suínos
4.
Molecules ; 26(11)2021 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-34200200

RESUMO

Epilobium angustifolium L. is a popular and well-known medicinal plant. In this study, an attempt to evaluate the possibility of using this plant in preparations for the care and treatment of skin diseases was made. The antioxidant, antiaging and anti-inflammatory properties of ethanolic extracts from Epilobium angustifolium (FEE) were assessed. Qualitative and quantitative evaluation of extracts chemically composition was performed by gas chromatography with mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC). The total polyphenol content (TPC) of biologically active compounds, such as the total content of polyphenols (TPC), flavonoids (TFC), and assimilation pigments, as well as selected phenolic acids, was assessed. FEE was evaluated for their anti-inflammatory and antiaging properties, achieving 68% inhibition of lipoxygenase activity, 60% of collagenase and 49% of elastase. FEE also showed high antioxidant activity, reaching to 87% of free radical scavenging using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 59% using 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). Additionally, in vitro penetration studies were performed using two vehicles, i.e., a hydrogel and an emulsion containing FEE. These studies showed that the active ingredients contained in FEE penetrate through human skin and accumulate in it. The obtained results indicate that E. angustifolium may be an interesting plant material to be applied as a component of cosmetic and dermatological preparations with antiaging and anti-inflammatory properties.


Assuntos
Cosméticos/química , Fármacos Dermatológicos/química , Epilobium/química , Extratos Vegetais/química , Anti-Inflamatórios/química , Antioxidantes/química , Compostos de Bifenilo/química , Cromatografia Líquida de Alta Pressão/métodos , Flavonoides/química , Cromatografia Gasosa-Espectrometria de Massas/métodos , Humanos , Plantas Medicinais/química , Polifenóis/química , Pele/efeitos dos fármacos
5.
Molecules ; 26(12)2021 Jun 16.
Artigo em Inglês | MEDLINE | ID: mdl-34208702

RESUMO

Coffee is one of the most often consumed beverages almost all over the world. The multiplicity of beans, as well as the methods and parameters used to brew, encourages the optimization of the brewing process. The study aimed to analyze the effect of roasting beans, the brewing technique, and its parameters (time and water temperature) on antioxidant activity (determined using several in vitro methods), total polyphenols, flavonoids, and caffeine content. The infusions of unroasted and roasted Arabica beans from Brazil, Colombia, India, Peru, and Rwanda were analyzed. In general, infusions prepared from roasted beans had higher antioxidant activity and the content of above-mentioned compounds. The hot brew method was used to obtain infusions with a higher antioxidant activity, while the cold brew with higher caffeine content. The phenolic compound content in infusions prepared using both techniques depended on the roasting process. Moreover, the bean's origin, roasting process, and brewing technique had a significant effect on the tested properties, in contrary to brewing time and water temperature (below and above 90 °C), which had less impact. The results confirm the importance of coffee brewing optimization.


Assuntos
Café/química , Antioxidantes/análise , Bebidas , Compostos de Bifenilo/análise , Brasil , Cafeína/análise , Coffea/química , Colômbia , Índia , Peru , Fenóis/análise , Extratos Vegetais/química , Polifenóis/análise , Sementes/química , Temperatura , Fatores de Tempo , Água/química
6.
Acta Sci Pol Technol Aliment ; 20(1): 37-46, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33449518

RESUMO

BACKGROUND: Extracts of milk thistle, particularly from seeds, are used as a valuable source of natural antioxidants in different industries, for example pharmaceutical and cosmetic. The leaves and flowers are also known to be a source of biologically active compounds, as well as those with an antioxidant capacity. The selection of the extraction parameters, such as type and concentration of extractant, and extraction time, have an impact on the antioxidant capacity of the obtained extracts. The aim of this study was to evaluate the antioxidant activities of extracts obtained using different parts of raw material. The impact of different parameters of extraction on antioxidant capacity was also assessed. METHODS: The seeds, flowers and leaves were extracted using a Soxhlet apparatus, ultrasound and shaking. 96% (v/v) and 70% (v/v) ethanol, concentrated methanol, acetone and petroleum ether were applied as solvents. The impact of the extraction time was also evaluated. The extracts were evaluated using DPPH, ABTS, FRAP and Folin-Ciocalteu techniques. RESULTS: The obtained extracts, except for the samples in petroleum ether, showed the antioxidant capacity. Soxhlet extraction, especially that which uses ethanol, methanol and acetone, seems to be a valuable extraction method. CONCLUSIONS: To sum up, many factors could affect the antioxidant capacity and the total polyphenol content of Silybum marianum L. extracts. The solvent and an appropriately selected extraction method seem to be important factors in the effective isolation of active substances and could lead to the more effective application of this valuable plant material in different industries.

7.
Molecules ; 26(2)2021 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-33435259

RESUMO

Epilobium angustifolium L. is applied as an antiseptic agent in the treatment of skin diseases. However, there is a lack of information on human skin penetration of active ingredients with antioxidative potential. It seems crucial because bacterial infections of skin and subcutaneous tissue are common and partly depend on oxidative stress. Therefore, we evaluated in vitro human skin penetration of fireweed ethanol-water extracts (FEEs) by determining antioxidant activity of these extracts before and after penetration study using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and Folin-Ciocalteu methods. Microbiological tests of extracts were done. The qualitative and quantitative evaluation was performed using gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC-UV) methods. The in vitro human skin penetration using the Franz diffusion chamber was assessed. The high antioxidant activity of FEEs was found. Gallic acid (GA), chlorogenic acid (ChA), 3,4-dihydroxybenzoic acid (3,4-DHB), 4-hydroxybenzoic acid (4-HB), and caffeic acid (CA) were identified in the extracts. The antibacterial activities were found against Serratia lutea, S. marcescens, Bacillus subtilis, B. pseudomycoides, and B. thuringiensis and next Enterococcus faecalis, E. faecium, Streptococcus pneumoniae, Pseudomonas aeruginosa, and P. fluorescens strains. In vitro penetration studies showed the penetration of some phenolic acids and their accumulation in the skin. Our results confirm the importance of skin penetration studies to guarantee the efficacy of formulations containing E. angustifolium extracts.


Assuntos
Anti-Infecciosos , Antioxidantes , Bactérias/crescimento & desenvolvimento , Bassia scoparia/química , Extratos Vegetais , Absorção Cutânea , Pele/metabolismo , Anti-Infecciosos/química , Anti-Infecciosos/farmacocinética , Anti-Infecciosos/farmacologia , Antioxidantes/química , Antioxidantes/farmacocinética , Antioxidantes/farmacologia , Etanol/química , Humanos , Extratos Vegetais/química , Extratos Vegetais/farmacocinética , Extratos Vegetais/farmacologia , Pele/microbiologia , Água/química
8.
AMB Express ; 10(1): 187, 2020 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-33078274

RESUMO

The aim of the study was to determine the antioxidant activity and assess the lipophilicity and skin penetration of eugenyl chloroacetate (EChA), eugenyl dichloroacetate (EDChA), and eugenyl trichloroacetate (ETChA). Identification of the obtained products was based on gas chromatography (GC), infrared spectroscopy (FTIR/ATR), gas chromatography coupled with mass spectrometry (GC-MS), and the analysis of 13C-NMR and 1H-NMR spectra. The antioxidative capacity of the derivatives obtained was determined by the DPPH free radical reduction method, while the octanol/water partition coefficient (shake-flask method) was tested to determine the lipophilicity of these compounds. In the next stage of testing EDChA and ETChA-(compounds characterized by the highest degree of free radical scavenging), the penetration of DPPH through pig skin and its accumulation in the skin were evaluated. For comparison, penetration studies of eugenol alone as well as dichloroacetic acid (DChAA) and trichloroacetic acid (TChAA) were also carried out. The antioxidant activity (DPPH, ABTS, and Folin-Ciocalteu methods) of the fluid that penetrated through pig skin was also evaluated. The in vitro pig skin penetration study showed that eugenol derivatives are particularly relevant for topical application. The obtained derivatives were characterized by a high level of antioxidant activity estimated after 24 h of conducting the experiment, which indicates long-term protection against reactive oxygen species (ROS) in the deeper layers of the skin.

9.
Acta Sci Pol Technol Aliment ; 19(3): 261-270, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32978909

RESUMO

BACKGROUND: The search for new sources of natural antioxidants is very important because many diseases are caused by oxidative stress. Fruit which contain antioxidants are an important part of a healthy diet. The aim of this study was to evaluate the antioxidant activity of extracts of both the fresh and frozen peel and the flesh of Garcinia mangostana L. METHODS: The extracts from the fresh and frozen peel and the flesh of mangosteen were prepared by ultrasound-assisted extraction using 20%, 40%, 70% and 96% (v/v) ethanol for 15, 30 or 60 minutes. The antioxidant potential was evaluated by the DPPH, ABTS, CUPRAC, FRAP and FIC methods, whereas the total phenolic content was measured using the Folin-Ciocalteu (F-C) technique. The contents of anthocyanins and flavonoids in the peel extracts were also determined. RESULTS: In most cases, the highest antioxidant activity was observed in the fresh peel samples. It was higher than the antioxidant potential of the frozen peels and the fresh and frozen flesh. The ultrasound-assisted extraction, in particular those lasting 30 or 60 minutes and using ethanol in concentrations higher than 20% (v/v), seemed to be an effective extraction process. CONCLUSIONS: The obtained results suggest that G. mangostana, in particular its peels, could be a valuable source of antioxidants. The extraction parameters, such as the time or solvent concentration, as well as the type of plant material, had an impact on the tested properties of the extracts. However, more detailed studies on the antioxidant activity of the studied plants are required.

10.
Acta Sci Pol Technol Aliment ; 18(4): 453-462, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31930795

RESUMO

BACKGROUND: The supplementation of antioxidants, in particular those of plant origin, may help to prevent the development of diseases caused by oxidative stress. Therefore, it is important to study plants for their antioxidant contents. Up to now, only a few reports on the antioxidant activity of different varieties and parts of grapefruit have been published. Therefore, the aim of this study was to evaluate the antioxidant potential of different parts and varieties of grapefruit. Moreover, the impact of different extraction parameters on the activity of the obtained extracts was estimated. METHODS: Extracts of albedo, flavedo and flesh from three varieties of grapefruit – red, white and sweetie – were obtained using ultrasound-assisted extraction (time – 5, 10, 15 and 30 minutes; solvents – distilled water as well as 20, 40, 70 and 96% (v/v) ethanol). The samples were evaluated using the DPPH, ABTS, FRAP and Folin-Ciocalteu methods. RESULTS: The extracts of peel (in particular, those of albedo) showed higher antioxidant potential than the samples of flesh. In the majority of cases, the highest potential in the group of flesh and flavedo extracts was observed in the sweetie samples. The highest activity in the group of albedo samples was found in the white grapefruit extracts. Parameters such as the type of solvent and the extraction time had an impact on the antioxidant activity of the obtained extracts. CONCLUSIONS: Grapefruit, in particular their peels, could be valuable sources of natural antioxidants. However, more detailed studies on the antioxidant properties of the studied plants are required.


Assuntos
Antioxidantes/análise , Citrus paradisi/química , Frutas/química , Extratos Vegetais/análise , Extratos Vegetais/isolamento & purificação , Antioxidantes/química , Especificidade da Espécie
11.
Hum Immunol ; 79(4): 213-217, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29454820

RESUMO

The role of interleukin-23 is crucial in the pathogenesis of psoriasis, and IL23A, IL12B and IL23R genetic variants have been associated with the disease in genome-wide association studies. In the current paper we have conducted a confirmation study of the abovementioned genetic factors in a case-control analysis of 507 psoriatic patients and 396 controls from a Polish population, and subsequently analyzed the impact of genetic variants on response to topical and NB-UVB therapy in a subset of 306 patients. Case-control analysis revealed an association of IL12B rs3212227 and IL23R rs11209026 minor allele carrier status with reduced odds for psoriasis (OR = 0.66, 95%CI: 0.50-0.87, and OR = 0.41, 95%CI: 0.26-0.67, respectively), while HLA-C*06 allele carriers were more frequent in patients group (OR = 4.56, 95%CI: 3.41-6.10). The studied polymorphic variants of IL12B, IL23A, and IL23R genes did not influence therapy outcome, i.e. there were no significant differences in PASI reduction between patients with different genotypes. However, HLA-C*06 carriers showed poorer response to the applied treatment, when compared to non-carriers. The results of the current study confirm an association between IL12B and IL23R genetic polymorphism and psoriasis vulgaris (with a protective effect of minor alleles). HLA-C*06 carriers show reduced effectiveness of topical/NB-UVB therapy, and that observation could be potentially used in treatment personalization.


Assuntos
Antígenos HLA-C/genética , Subunidade p40 da Interleucina-12/genética , Subunidade p19 da Interleucina-23/genética , Psoríase/genética , Receptores de Interleucina/genética , Adulto , Alelos , Estudos de Casos e Controles , Feminino , Frequência do Gene , Predisposição Genética para Doença , Haplótipos , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único , Psoríase/terapia , Resultado do Tratamento , Terapia Ultravioleta/métodos
12.
Dermatology ; 232(5): 592-596, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27591988

RESUMO

BACKGROUND: Recent studies have revealed the pivotal role of Th17 cells and interleukin-17 (IL-17) in plaque psoriasis development and treatment outcome. The IL-17 family consists of 6 structurally related cytokines (IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F), of which IL-17A and IL-17F mediate similar biological effects. OBJECTIVES: The aim of this study was to evaluate an association between the IL17A (-197G>A; rs2275913) and IL17F (rs763780: T>C; rs11465553: G>A; rs2397084: T>C) polymorphisms with psoriasis susceptibility as well as response to topical and combined topical with narrow-band ultraviolet B (NB-UVB) therapy in a Polish population. METHODS: Association study involving 407 psoriasis patients and 205 healthy controls. Treatment efficacy was analyzed in 207 patients with mild psoriasis (Psoriasis Area and Severity Index; PASI 3-12) and moderate psoriasis (PASI 12-18), who were randomly subjected to topical or combined topical and NB-UVB treatment. The polymorphisms were evaluated by RT-PCR. RESULTS: No statistically significant differences between psoriasis patients and controls were found in the frequency of the evaluated IL17A and IL17F genotypes and haplotypes. The IL17A or IL17F polymorphisms were not associated with treatment outcome measures: efficacy of treatment at the eighth week of the study and PASI change after topical or combined topical and NB-UVB therapy. However, IL17F rs2397084 variant allele C carriers required a significantly higher number of NB-UVB irradiations in comparison to TT homozygotes (15.5 ± 11.4 vs. 11.1 ± 11.9, p = 0.047) to produce a positive clinical response. CONCLUSION: It can be stated that the IL17A and IL17F polymorphisms are not markers of susceptibility to psoriasis. However, the IL17F polymorphism may affect the response to NB-UVB therapy.


Assuntos
Fármacos Dermatológicos/uso terapêutico , Interleucina-17/genética , Psoríase/genética , Psoríase/terapia , Terapia Ultravioleta , Administração Cutânea , Adulto , Estudos de Casos e Controles , Terapia Combinada , Fármacos Dermatológicos/administração & dosagem , Feminino , Predisposição Genética para Doença , Humanos , Masculino , Pessoa de Meia-Idade , Polônia , Polimorfismo de Nucleotídeo Único , Distribuição Aleatória , Fatores de Risco , Índice de Gravidade de Doença
13.
Pomeranian J Life Sci ; 62(4): 52-9, 2016.
Artigo em Polonês | MEDLINE | ID: mdl-29537790

RESUMO

Introduction: Antioxidants contained in plant raw materials prevent oxidative stress, and reduce the degenerative effects of free radical reactions and damage caused by UV radiation. Antioxidant activity is exhibited, for example, in raspberry (Rubus idaeus), and blackberry (Rubus fruticosus), which have a high content of tannins, flavonoids, phenolic acids, vitamins and minerals. Materials and methods: The raw plant material consisted of fresh and dried leaves and fruits of raspberries and blackberries harvested in 2014. This material was extracted using a Soxhlet apparatus and by an ultrasound-assisted technique. To evaluate antioxidant activity DPPH and FRAP methods were used in the first year and DPPH and ABTS methods in the second year of the study. Results: The highest antioxidant activity, evaluated by the DPPH method in 2015, was demonstrated by both raspberry and blackberry fresh leaf extracts, whereas the highest reductive ability, assessed by FRAP, was demonstrated in fresh and dried blackberry leaves. In the next year of the study (2016), the activity of samples evaluated using the DPPH method did not differ significantly, with the exception of fresh raspberry leaf. In this year, the highest antioxidant properties, assessed using the ABTS method, were shown by extracts made of fresh blackberry leaves and fruits, and dried blackberry leaves. Conclusions: All the studied material, both ethanolic leaves and fruit extracts of raspberry and blackberry, reduced free radicals, which was examined using three methods of evaluation of the antioxidative properties (DPPH, FRAP and ABTS). The storage of ethanolic extracts at ambient temperature had no significant impact on the activity reduction of the evaluated plant material. The antioxidant activity of most examined extracts remained consistently high, which may be reflected in the use of the studied materials as sources of antioxidants in the cosmetics and pharmaceuticals industries.


Assuntos
Antioxidantes/análise , Frutas/química , Folhas de Planta/química , Rubus/química , Flavonoides/análise , Hidroxibenzoatos/análise , Taninos/análise
14.
Exp Dermatol ; 24(2): 146-7, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25357087

RESUMO

Interleukin-6 (IL-6) is implicated in the pathogenesis of psoriasis as well as in its treatment efficacy. The aim of this study of 406 patients with psoriasis and 203 healthy controls was to evaluate the association between the IL6 -174G>C (rs1800795) polymorphism and psoriasis susceptibility, as well as treatment efficacy. The frequency of genotype GG (33.7% vs. 20.7%; P = 0.00022; OR = 0.51, 95% confidence interval 0.34-0.76) and of allele G (56.2% vs. 46.8%; P = 0.0023) was significantly higher in the psoriasis group compared with controls. No polymorphism variants were associated with better response to topical or combined topical/narrow-band ultraviolet B (NB-UVB) treatment. We conclude that the IL6 -174G>C polymorphism can be a marker of susceptibility to psoriasis, with an almost twofold increased risk of the disease in individuals carrying the GG genotype; however, it was not associated with treatment response to topical and/or NB-UVB therapy.


Assuntos
Interleucina-6/genética , Polimorfismo Genético , Psoríase/genética , Psoríase/radioterapia , Adulto , Alelos , Estudos de Casos e Controles , Feminino , Predisposição Genética para Doença , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Resultado do Tratamento , Raios Ultravioleta
15.
Ann Acad Med Stetin ; 58(1): 62-5; discussion 65, 2012.
Artigo em Polonês | MEDLINE | ID: mdl-23547397

RESUMO

Inulin, a natural oligomer of fructose, is classified as a food component. It can be found in some plants and vegetables, i.e. chicory, Jerusalem artichoke, elecampane, and dandelion. Following ingestion, inulin reaches the lower part of the gastrointestinal tract where it is fermented increasing the bifidobacterial population of the colon. The growth of bifidobacteria regulates cholesterol concentration and absorption of minerals. Inulin added to food may prevent the spread of civilization diseases, like diabetes and obesity.


Assuntos
Inulina/química , Inulina/farmacologia , Bifidobacterium/crescimento & desenvolvimento , Colesterol/farmacocinética , Colo/microbiologia , Diabetes Mellitus/prevenção & controle , Humanos , Absorção Intestinal , Inulina/farmacocinética , Estrutura Molecular , Obesidade/prevenção & controle
16.
Ann Acad Med Stetin ; 57(3): 23-7, 2011.
Artigo em Polonês | MEDLINE | ID: mdl-23383544

RESUMO

Vitiligo is an idiopathic chronic skin disease that is notable for depigmented macules forming by destruction of melanocytes mediated by cells of the immune system. Vitiligo occurs in 1-2% of the population irrespective of race and without predilection to gender or age. The dynamics and extent of the disease vary widely, ranging from stable cases with isolated minor foci to states showing rapid progression and occupying large areas of the skin. For many patients, the disease represents a serious cosmetic defect which limits their activities in various spheres of life. There are many noninvasive methods of treatment but none of them offers a guarantee of complete therapeutic success. PUVA- and UVB-therapy are recognized as the most effective and most commonly used methods. The management of vitiligo should also include education, cosmetic correction options, and psychotherapy in some cases.


Assuntos
Estética , Vitiligo/terapia , Progressão da Doença , Humanos , Hipopigmentação/etiologia , Hipopigmentação/prevenção & controle , Hipopigmentação/psicologia , Terapia PUVA , Fototerapia , Psicoterapia , Terapia Ultravioleta , Vitiligo/complicações
17.
Ann Acad Med Stetin ; 54(3): 54-7, 2008.
Artigo em Polonês | MEDLINE | ID: mdl-19839512

RESUMO

The paper presents current opinions on aetiopathogenesis of dry skin including its occurrence in the course of certain dermatological disorders. A meaning of natural moisturizing factor, lipid barrier as well as epidermal differentiation processes in the maintenance of the proper skin moisturization is described. The importance of topical treatment is emphasized. Moreover, a survey of moisturizing factors applied in dry skin care is included.


Assuntos
Cosméticos/administração & dosagem , Higiene da Pele/métodos , Dermatopatias/terapia , Administração Tópica , Diferenciação Celular , Epiderme/patologia , Humanos , Dermatopatias/patologia
18.
Ann Acad Med Stetin ; 54(3): 126-9, 2008.
Artigo em Polonês | MEDLINE | ID: mdl-19839524

RESUMO

Androgenetic alopecia is a fairly common disorder which causes serious aesthetic and psychological problems. The paper discusses the etiology, diagnostics and possible treatment of androgenetic alopecia in women. Preparations for both general and external use in treatment of this dermatosis have been presented herein.


Assuntos
Alopecia/psicologia , Alopecia/diagnóstico , Alopecia/tratamento farmacológico , Alopecia/etiologia , Estética , Feminino , Humanos
19.
Ann Acad Med Stetin ; 54(2): 52-8, 2008.
Artigo em Polonês | MEDLINE | ID: mdl-19374232

RESUMO

INTRODUCTION: Every adverse and undesirable event observed after administration of the therapeutic dose of the drug is defined as adverse drug reaction. The aim of the study was to evaluate the incidence frequency of cutaneous adverse drug reactions, to define the drugs inducing such reactions and to define the type of the most frequently found lesions in patients admitted to Department of Dermatology and Venereology of Pomeranian Medical University in Szczecin (PAM) in 1996-2006. MATERIAL AND METHODS: A retrospective analysis of medical files of the patients, who were hospitalized in the Department of Dermatology and Venereology of PAM in Szczecin in 1996-2006, was carried out. Due to cutaneous adverse drug reactions, 386 patients were hospitalized. They made 4.25% of all admitted to our Department. RESULTS: These reactions were found more frequently in females (65.5%) than in males (34.5%). Non-steroidal anti-inflammatory drugs induced adverse events most frequently (37.6%), followed by aminopenicillin antibiotics, particularly amoxycillin-containing agents, responsible for 25.8% of these reactions. Other antibiotics were responsible for undesirable events less frequently--9.6%. Macular and maculopapular rashes were the most frequently observed adverse cutaneous drug reactions (42.0% of the cases), followed by acute urticaria and Quincke's oedema (39.1% of all reactions), whereas contact dermatitis after topical drugs was found in 8.0% of the cases. CONCLUSIONS: Cutaneous adverse drug reactions were mainly induced by non-steroidal anti-inflammatory drugs and aminopenicillin antibiotics. The most frequent forms of cutaneous adverse drug reactions were maculopapular rashes, acute urticaria and Quincke's oedema.


Assuntos
Erupção por Droga/epidemiologia , Administração Tópica , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/administração & dosagem , Antibacterianos/efeitos adversos , Anti-Inflamatórios não Esteroides/efeitos adversos , Anticonvulsivantes/efeitos adversos , Fármacos Cardiovasculares/efeitos adversos , Erupção por Droga/classificação , Erupção por Droga/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Polônia/epidemiologia , Estudos Retrospectivos , Distribuição por Sexo
20.
Ann Acad Med Stetin ; 53(2): 8-13; discussion 13, 2007.
Artigo em Polonês | MEDLINE | ID: mdl-18557371

RESUMO

Biological agents belong to a novel therapy method. Their immunomodulatory activity is used in treating some of the severe and chronic skin diseases. This paper presents the structure and activity of biological agents, enumerates preparations most commonly used in dermatology, their side effects and contraindications.


Assuntos
Fatores Biológicos/uso terapêutico , Produtos Biológicos/uso terapêutico , Fármacos Dermatológicos/uso terapêutico , Dermatopatias/terapia , Humanos , Dermatopatias/tratamento farmacológico , Linfócitos T/efeitos dos fármacos
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