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1.
Rev Saude Publica ; 53: 106, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31800907

RESUMO

BACKGROUND: Although the prognosis of differentiated thyroid carcinoma (DTC) therapy is considered excellent over time, some cases have a poorer prognosis and evolve into death. OBJECTIVE: This study aimed to estimate the 5-year specific survival and to identify prognosis factors in a cohort of DTC adult subjects. METHODS: Survival probability was estimated by Kaplan-Meier's method in a retrospective hospital-based cohort study. Comparisons were made by log-rank test. Prognosis factors were identified using Cox risk modeling and crude and adjusted Hazard Ratio measures were obtained. Two models were estimated, considering age grouping of the 7th and 8th editions of TNM. RESULTS: Specific 5-year survival in the cohort was 98.5% (95%CI: 94.2 - 97.5). Considering TNM 7th edition, the risk estimates were 9.88 (95%CI: 1.67 - 58.33) for age group ≥ 55 years, 18.87 (95%CI: 7.38 - 48.29) for individuals with distant metastasis, 6.36 (95%CI: 2.26 - 17.91) for patients who underwent lymphadenectomy and 0.16 (95%CI: 0.06 - 0.43) for those who received radioiodine therapy. For TNM 8th edition, the risk estimates were 10.12 (95%CI: 2.05 - 50.09) for age group ≥ 55 years, 12.43 (95%CI: 4.58 - 33.77) for individuals with distant metastasis, 5.06 (95%CI: 1.82 - 14.05) for patients who underwent lymphadenectomy and 0.19 (95%CI: 0.07 - 0.51) for those who received radioiodine therapy. CONCLUSIONS: This cohort had a very high survival over a 5-year period. The prognosis was negatively influenced by age, distant metastasis and lymphadenectomy, whereas radioiodine therapy was found to be protective.


Assuntos
Carcinoma/mortalidade , Encaminhamento e Consulta/estatística & dados numéricos , Neoplasias da Glândula Tireoide/mortalidade , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Brasil/epidemiologia , Carcinoma/patologia , Feminino , Seguimentos , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Estadiamento de Neoplasias , Prognóstico , Estudos Retrospectivos , Taxa de Sobrevida , Neoplasias da Glândula Tireoide/patologia , Fatores de Tempo , Carga Tumoral , Adulto Jovem
2.
Rev Saude Publica ; 53: 88, 2019.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31596321

RESUMO

OBJECTIVE: To determine the distribution of sociodemographic, reproductive, clinical and lifestyle habits in the cohort of women diagnosed with cervical cancer, assisted at Inca between 2012 and 2014, according to the histological type. METHODS: Retrospective observational study of a hospital cohort of 1,004 women diagnosed with cervical cancer. Data were obtained from the Inca hospital cancer registry, physical and electronic records. RESULTS: The most frequent histological type was squamous cell carcinoma (83.9%). Approximately 70% of the women aged more than 40 years. The study includes non-white women (67.4%), with less than 8 years of education (51.9%), with onset of sexual activity up to 16 years of age (40.7%), who were pregnant before (95.5%), with more than one pregnancy (82.9%), and more than two children (52.7%); 45.8% of the women were smokers or former smokers. Cervical adenocarcinoma was positively associated with earlier staging (IA-IIA) (OR = 1.79; 95%CI 1.03-3.13), as well as women with ≥ 12 years of education (OR = 6.30; 95%CI 1.97-20,13), who had no children (OR = 3.81; 95%CI 1.20 - 12,08) or who had up to two children (OR = 1.74; 95%CI 1.05 - 2,87). CONCLUSIONS: The difference between histological types is highlighted, suggesting that women with cervical adenocarcinoma may represent a distinct clinical entity of cervical neoplasia, which may require different approaches from those used in squamous cell carcinoma.


Assuntos
Adenocarcinoma/epidemiologia , Carcinoma de Células Escamosas/epidemiologia , Neoplasias do Colo do Útero/epidemiologia , Adenocarcinoma/patologia , Adulto , Distribuição por Idade , Brasil/epidemiologia , Carcinoma de Células Escamosas/patologia , Feminino , Humanos , Estilo de Vida , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Estudos Retrospectivos , Fatores de Risco , Comportamento Sexual , Fatores Socioeconômicos , Neoplasias do Colo do Útero/patologia
3.
Nutrition ; 65: 126-130, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31082790

RESUMO

OBJECTIVES: It is unclear whether addition of soluble fiber to a low-calorie diet potentializes weight loss and amelioration of metabolic syndrome (MetS). The aim of this study was to analyze the effects of oat bran on prevalence of MetS and associated disorders. METHODS: A pragmatic, randomized controlled, 6-wk nutritional trial was carried out with 154 outpatients (mean age 47.6 ± 12.6 y of age). The intervention group (n = 83) received a low-calorie diet plus 40 g/d of oat bran; the control group (n = 71) received a low-calorie diet only. MetS parameters and prevalence were calculated and compared (using two-tailed statistical tests) before and after follow-up. RESULTS: After follow-up, a significant but similar reduction was observed in MetS prevalence (40% reduction, 63% and 64.8% prevalence in intervention and control groups, respectively; P = 0.226), body mass index, body weight, waist circumference, systolic and diastolic blood pressures, triacylglycerides, and blood glucose levels in both groups (P < 0.05). Mean high-density lipoprotein cholesterol (HDL-C) was reduced in the intervention group (43.6 ± 9.6 to 41.2 ± 9.5 mg/dL; P = 0.025), but not in the control group (44.6 ± 10.5 to 44.5 ± 12.1 mg/dL; P = 0.890). There was no significant difference in any of the variables between the groups, although the P-value for HDL-C was almost significant (P = 0.078). Calorie and dietetic fiber intake during the 6-wk period were similar in both groups. CONCLUSIONS: Daily consumption of oat bran did not potentialize the beneficial effects of a traditional low-calorie diet on the prevalence of MetS and associated disorders. Additionally, it reduced HDL-C.

4.
Cad Saude Publica ; 35(5): e00143818, 2019 May 23.
Artigo em Português | MEDLINE | ID: mdl-31141029

RESUMO

The study aimed to estimate cancer mortality among indigenous peoples in Acre State, Brazil. This was a descriptive observational study based on the nominal bank of the Brazilian Mortality Information System for the period from January 1st, 2000, to December 31st, 2012. The study analyzed the distribution death frequencies by sex and age. Standardized mortality ratio (SMR) was calculated taking Goiânia (Goiás State), Acre State, and the North Region of Brazil as the references. A total of 81 deaths were identified, the majority in men (59.3%) and in individuals over 70 years of age. The five main sites in men were stomach, liver, colon and rectum, leukemia, and prostate. The five main sites in women were uterine cervix, stomach, liver, leukemia, and uterus. In indigenous men there was an excess of deaths from stomach cancer compared to the populations of Goiânia (SMR = 2.72; 2.58-2.87), Acre State (SMR = 2.05; 1.94-2.16) and North region (SMR = 3.10; 2.93-3.27). The same was observed for deaths from hepatic cell carcinomas referenced against Goiânia (SMR = 3.89; 3.66-4.14), Acre State (SMR = 1.79; 1.68-1.91), and the North of Brazil (SMR = 4.04; 3.77-4.30). Among indigenous women, there was an excess of cervical cancer in comparison to Goiânia (SMR = 4.67; 4.41-4.93), Acre State (SMR = 2.12; 2.00-2.24), and the North (SMR = 2.60; 2.45-2.75). The estimates show that preventable neoplasms such as cervical cancer and those linked to underdevelopment, such as stomach and liver cancer, account for 49.4% of deaths among indigenous peoples. Compared to the reference population, mortality from liver, stomach, and colorectal cancer and leukemias was more than twice as high in indigenous men; among indigenous women, cervical, stomach, and liver cancer and leukemias were 30% higher.

5.
Rev. bras. ginecol. obstet ; 41(4): 242-248, Apr. 2019. tab
Artigo em Inglês | LILACS-Express | ID: biblio-1013600

RESUMO

Abstract Objective To analyze the factors associated with health-related quality of life (HRQoL) in women with cervical cancer (CC) in a single center in Rio de Janeiro, state of Rio de Janeiro, Brazil. Methods A cross-sectional study in women with a diagnosis of CC followed-up in the gynecology outpatient clinic of the Hospital do Câncer II (HCII, in the Portuguese acronym) of the Instituto Nacional de Câncer (INCA, in the Portuguese acronym). The data were collected from March to August 2015. Women with palliative care, communication/cognition difficulty, undergoing simultaneous treatment for other types of cancer, or undergoing chemotherapy and/or radiation therapy were excluded. For the evaluation of the HRQoL, a specific questionnaire for women with CC was used (Functional Assessment of Cancer Therapy - Cervix Cancer [FACT-Cx]). The total score of the questionnaire ranges from 0 to 168, with higher scores indicating a better HRQoL. Results A total of 115 women were included in the present study, with a mean age of 52.64 years old (standard deviation [SD] = 12.13). The domains of emotional (16.61; SD = 4.55) and functional well-being (17.63; SD = 6.15) were those which presented the worst scores. The factors that had an association with better HRQoL in women with CC were having a current occupation, a longer time since the treatment and diagnosis, and women who had undergone hysterectomy. Conclusion Considering the domains of HRQoL of the women treated for cervical cancer, a better score was observed in the domains of physical and social/family wellbeing. For most domains, better scores were found between those with a current occupation, with a longer time after the diagnosis and treatment, and among those who had undergone a hysterectomy.


Resumo Objetivo Analisar os fatores associados à qualidade de vida em mulheres com câncer de colo do útero tratadas em um hospital de referência no Rio de Janeiro, RJ, Brasil. Métodos Estudo transversal em mulheres com diagnóstico de câncer do colo do útero emseguimento ambulatorial no Hospital de Câncer II (HCII) do Instituto Nacional de Câncer (INCA). Os dados foram coletados no período de março a agosto de 2015. Foram excluídas as mulheres em cuidados paliativos, comdificuldade de comunicação/cognição, que estavam em tratamento simultâneo para outros tipos de câncer, ou em quimioterapia e/ou radioterapia. Para a avaliação da qualidade de vida relacionada à saúde, foi utilizado um questionário específico para mulheres com câncer de colo do útero (Avaliação Funcional da Terapia do Câncer - Câncer Cervical (FACT-Cx, na sigla em inglês). O escore total do questionário varia de 0 a 168, com escores mais altos indicando melhor qualidade de vida relacionada à saúde. Resultados Foram incluídas 115 mulheres com uma média de idade de 52,64 anos (desvio padrão [DP] = 12,13). Os domínios de questões emocionais (16,61; DP = 4,55) e de bem-estar funcional (17,63; DP = 6,15) foram os que apresentaram os piores escores. Os fatores que tiveram associação com melhor qualidade de vida relacionada à saúde em mulheres com câncer de colo do útero foram ocupação atual, maior tempo após o tratamento e diagnóstico, e mulheres que haviamsido submetidas a histerectomia. Conclusão Considerando os domínios da qualidade de vida relacionada à saúde de mulheres tratadas para câncer do colo do útero, foi observado melhor escore nos domínios de bem-estar físico e social. Para amaioria dos domínios, osmelhores escores foram observados entre aquelas com ocupação atual, com mais tempo após o diagnóstico e tratamento, além daquelas que se submeteram a histerectomia.

6.
Rev Bras Ginecol Obstet ; 41(4): 242-248, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30847876

RESUMO

OBJECTIVE: To analyze the factors associated with health-related quality of life (HRQoL) in women with cervical cancer (CC) in a single center in Rio de Janeiro, state of Rio de Janeiro, Brazil. METHODS: A cross-sectional study in women with a diagnosis of CC followed-up in the gynecology outpatient clinic of the Hospital do Câncer II (HCII, in the Portuguese acronym) of the Instituto Nacional de Câncer (INCA, in the Portuguese acronym). The data were collected from March to August 2015. Women with palliative care, communication/cognition difficulty, undergoing simultaneous treatment for other types of cancer, or undergoing chemotherapy and/or radiation therapy were excluded. For the evaluation of the HRQoL, a specific questionnaire for women with CC was used (Functional Assessment of Cancer Therapy - Cervix Cancer [FACT-Cx]). The total score of the questionnaire ranges from 0 to 168, with higher scores indicating a better HRQoL. RESULTS: A total of 115 women were included in the present study, with a mean age of 52.64 years old (standard deviation [SD] = 12.13). The domains of emotional (16.61; SD = 4.55) and functional well-being (17.63; SD = 6.15) were those which presented the worst scores. The factors that had an association with better HRQoL in women with CC were having a current occupation, a longer time since the treatment and diagnosis, and women who had undergone hysterectomy. CONCLUSION: Considering the domains of HRQoL of the women treated for cervical cancer, a better score was observed in the domains of physical and social/family well-being. For most domains, better scores were found between those with a current occupation, with a longer time after the diagnosis and treatment, and among those who had undergone a hysterectomy.


Assuntos
Carcinoma de Células Escamosas/psicologia , Qualidade de Vida , Neoplasias do Colo do Útero/psicologia , Instituições de Assistência Ambulatorial , Brasil , Carcinoma de Células Escamosas/patologia , Estudos Transversais , Feminino , Humanos , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Neoplasias do Colo do Útero/patologia , Saúde da Mulher
7.
Asian Pac J Cancer Prev ; 20(2): 469-478, 2019 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-30803209

RESUMO

Objective: Evaluate the beliefs about the risk factors for breast cancer in a population of women from the western Amazon and determine the factors associated with the higher belief scores presented by this population. Methods: A population-based cross-sectional study included 478 women aged >40 years residing in Rio Branco, Acre, Brazil. An American Cancer Society questionnaire was applied to assess the knowledge, attitudes, and beliefs about breast cancer. Results: The main beliefs about the risk factors for breast cancer were breast trauma (95%), use of underwire bra (58.5%), and a high number of sexual partners (55.5%). Women from younger age groups presented higher belief scores (Bcoefficient: ­0.04, 95% CI: ­0.07; ­0.01) than those of women from older age groups. A strong association was noted between high knowledge scores of risk factors and signs/symptoms of the disease and high belief scores in the study group (Bcoefficient:0.33;95%CI:0.28;0.38). Conclusion: The results indicate the existence of important beliefs related to the risk factors for breast cancer. Women from younger age groups, women who have seen a gynecologist in the past 2 years, and women who had more knowledge about the risk factors and signs and symptoms of breast cancer had higher belief scores.


Assuntos
Neoplasias da Mama/psicologia , Autoexame de Mama/psicologia , Comportamentos Relacionados com a Saúde , Conhecimentos, Atitudes e Prática em Saúde , Mamografia/psicologia , Adulto , Idoso , Brasil/epidemiologia , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/epidemiologia , Estudos Transversais , Feminino , Humanos , Pessoa de Meia-Idade , Prognóstico , Inquéritos e Questionários
8.
J Glob Oncol ; 5: 1-11, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30694738

RESUMO

PURPOSE: To estimate treatment delays and associated factors among women diagnosed with cervical cancer who were treated at the main cancer center in Rio de Janeiro, Brazil. MATERIALS AND METHODS: A retrospective cohort study was performed comprising 865 women newly diagnosed with cervical cancer between 2012 and 2014. Times from diagnosis to treatment initiation (less than or equal to 60 days) and from diagnosis to treatment ending (less than or equal to 120 days) were analyzed according to the Brazilian law for the treatment of patients with cancer. Associations between treatment delays and sociodemographic, economic, lifestyle, clinical, and treatment variables were estimated using logistic regression models, with 95% CIs. RESULTS: The average age was 48 (± 13.7) years, and the median age was 47 years; 36.2% of patients had stage IIIB to IVA disease. The median time from diagnosis to treatment initiation was 114 days, which was statistically higher among women with stage IIB to IVA (105.5 days) compared with those with earlier stages (119 days). The delay in treatment initiation occurred in 92.8% of participants; the median time from diagnosis to treatment ending was 274 days, with a delay (more than 120 days) for 92.6% of patients. The median time interval from diagnosis to the first visit to the cancer center was 28 days, with a delay of more than 30 days for 46.6% of patients. Age (odds ratio [OR], 1.05; 95% CI,1.02 to 1.08), stage IIIB to IVA (OR, 0.38; 95% CI, 0.16 to 0.90), time to first visit to the cancer center (OR, 11.52; 95% CI, 4.32 to 30.66), chemoradiation treatment (OR, 4.56; 95% CI, 1.81 to 11.47), and adequate treatment (OR, 2.57; 95% CI, 1.26 to -5.40) were independently associated with delay of treatment initiation. CONCLUSION: Significant delays in treatment initiation and ending were observed in this studied population. The treatment initiation delay was positively associated with age, time interval more than 30 days from diagnosis to first specialist assessment at the cancer center, treatment with chemoradiation, and adequate treatment.

9.
Cien Saude Colet ; 24(1): 261-273, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30698259

RESUMO

Breast cancer survival in Latin America countries is below Central European countries. Hospital-based breast cancer survival studies in western Amazon, Brazil, are lacking. This article aims to estimate hospital-based breast cancer survival in Rio Branco, Acre, and predictor factors. Hospital-based cohort study of all women diagnosed with breast cancer (2007-2012) was proceeded. Information were obtained from medical reports, and follow-up was until 2013. One-, 2- and 5- years breast cancer specific-survival were estimated by Kaplan-Meier method. Crude and adjusted Harzards Ratios (HR) were estimated by proportional Cox regression model. One-, 2-, and 5-year overall breast cancer survival were 95.5%, 83.7%, and 87.3% respectively. Surgery combined to radiotherapy significantly affected 1-, 2-, and 5-year survival (99%, 94%, and 90.6%, respectively) as compared to other treatments (77%,57.1%, and 37.5%, respectively). Comparing to surgery combined to radiotherapy treatment, surgery alone increased the risk of death, independently of age and stage (HR = 7.23;95%CI:2.29-22.83). In Rio Branco, Acre, 5-year breast cancer survival is similar to more developed areas in Brazil. Surgery combined to radiotherapy was independently associated to a lower risk of death as compared to surgery alone and other treatment.


Assuntos
Neoplasias da Mama/terapia , Hospitalização , Adulto , Idoso , Idoso de 80 Anos ou mais , Brasil , Neoplasias da Mama/patologia , Estudos de Coortes , Terapia Combinada , Feminino , Seguimentos , Humanos , Estimativa de Kaplan-Meier , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Taxa de Sobrevida , Fatores de Tempo , Adulto Jovem
10.
Rev. saúde pública (Online) ; 53: 88, jan. 2019. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-1043327

RESUMO

ABSTRACT OBJECTIVE To determine the distribution of sociodemographic, reproductive, clinical and lifestyle habits in the cohort of women diagnosed with cervical cancer, assisted at Inca between 2012 and 2014, according to the histological type. METHODS Retrospective observational study of a hospital cohort of 1,004 women diagnosed with cervical cancer. Data were obtained from the Inca hospital cancer registry, physical and electronic records. RESULTS The most frequent histological type was squamous cell carcinoma (83.9%). Approximately 70% of the women aged more than 40 years. The study includes non-white women (67.4%), with less than 8 years of education (51.9%), with onset of sexual activity up to 16 years of age (40.7%), who were pregnant before (95.5%), with more than one pregnancy (82.9%), and more than two children (52.7%); 45.8% of the women were smokers or former smokers. Cervical adenocarcinoma was positively associated with earlier staging (IA-IIA) (OR = 1.79; 95%CI 1.03-3.13), as well as women with ≥ 12 years of education (OR = 6.30; 95%CI 1.97-20,13), who had no children (OR = 3.81; 95%CI 1.20 - 12,08) or who had up to two children (OR = 1.74; 95%CI 1.05 - 2,87). CONCLUSIONS The difference between histological types is highlighted, suggesting that women with cervical adenocarcinoma may represent a distinct clinical entity of cervical neoplasia, which may require different approaches from those used in squamous cell carcinoma.


RESUMO OBJETIVO Determinar a distribuição das características sociodemográficas, reprodutivas, clínicas e de hábitos de vida na coorte de mulheres diagnosticadas com câncer cervical, atendidas no Inca entre 2012 e 2014, segundo o tipo histológico. MÉTODOS Estudo observacional retrospectivo de uma coorte hospitalar de 1.004 mulheres diagnosticadas com câncer cervical. Os dados foram obtidos pelo Registro Hospitalar de Câncer do Inca, prontuários físicos e eletrônicos. RESULTADOS O tipo histológico mais frequente foi o carcinoma de células escamosas (83,9%). Aproximadamente 70% das mulheres foram diagnosticadas com mais de 40 anos de idade. Houve a predominância de mulheres não brancas (67,4%), com menos de 8 anos de escolaridade (51,9%), com início da atividade sexual até 16 anos de idade (40,7%), que já engravidaram alguma vez na vida (95,5%), com mais de uma gestação (82,9%) e mais de dois filhos (52,7%); 45,8% das mulheres eram tabagistas ou ex-tabagistas. O adenocarcinoma cervical esteve positivamente associado ao estadiamento mais precoce (IA-IIA) (OR = 1,79; IC95% 1,03-3,13), assim como a mulheres com ≥ 12 anos de estudo (OR = 6,30; IC95% 1,97-20,13), que não tiveram filhos (OR = 3,81; IC95% 1,20-12,08) ou que tiveram até dois filhos (OR = 1,74; IC95% 1,05-2,87). CONCLUSÕES Destaca-se a diferença entre os tipos histológicos, sugerindo que as mulheres com adenocarcinoma cervical possam representar uma entidade clínica distinta de neoplasia cervical, podendo demandar abordagens diferentes das utilizadas no carcinoma de células escamosas.

11.
Cad. Saúde Pública (Online) ; 35(5): e00143818, 2019. tab
Artigo em Português | LILACS-Express | ID: biblio-1001663

RESUMO

O objetivo do estudo foi estimar a mortalidade por câncer em povos indígenas no Estado do Acre, Brasil. Trata-se de estudo observacional descritivo, com base no banco nominal do SIM (Sistema de Informações sobre Mortalidade), referente ao período de 1º de janeiro de 2000 a 31 de dezembro de 2012. Foi analisada a distribuição de frequência de óbitos, por sexo e faixa etária, e calculada a RMP (razão de mortalidade padronizada), tendo como referência Goiânia (Goiás), Acre e Região Norte. Foram identificados 81 óbitos, a maioria de homens (59,3%) e acima de 70 anos. As cinco principais localizações em homens foram estômago, fígado, cólon e reto, leucemia e próstata. Nas mulheres, câncer cervical, estômago, fígado, leucemia e útero. Nos homens indígenas houve excesso de óbitos por câncer de estômago quando comparados às populações de Goiânia (RMP = 2,72; 2,58-2,87), Acre (RMP = 2,05; 1,94-2,16) e Região Norte (RMP = 3,10; 2,93-3,27). O mesmo foi observado para óbitos por hepatocarcinomas, tendo por referência Goiânia (RMP = 3,89; 3,66-4,14), Acre (RMP = 1,79; 1,68-1,91) e Região Norte (RMP = 4,04; 3,77-4,30). Dentre as mulheres indígenas, destaca-se o excesso de câncer cervical em relação à Goiânia (RMP = 4,67; 4,41-4,93), Acre (RMP = 2,12; 2,00-2,24) e Região Norte (RMP = 2,60; 2,45-2,75). As estimativas apontam que neoplasias passíveis de prevenção, como câncer cervical, e ligadas ao subdesenvolvimento, como estômago e fígado, corresponderam a cerca de 49,4% dos óbitos entre indígenas. Comparados à população de referência, a mortalidade por câncer de fígado, estômago, colorretal e leucemias foi maior que o dobro entre os homens indígenas; por câncer cervical, estômago, fígado e leucemias esteve acima de 30% entre as mulheres indígenas.


The study aimed to estimate cancer mortality among indigenous peoples in Acre State, Brazil. This was a descriptive observational study based on the nominal bank of the Brazilian Mortality Information System for the period from January 1st, 2000, to December 31st, 2012. The study analyzed the distribution death frequencies by sex and age. Standardized mortality ratio (SMR) was calculated taking Goiânia (Goiás State), Acre State, and the North Region of Brazil as the references. A total of 81 deaths were identified, the majority in men (59.3%) and in individuals over 70 years of age. The five main sites in men were stomach, liver, colon and rectum, leukemia, and prostate. The five main sites in women were uterine cervix, stomach, liver, leukemia, and uterus. In indigenous men there was an excess of deaths from stomach cancer compared to the populations of Goiânia (SMR = 2.72; 2.58-2.87), Acre State (SMR = 2.05; 1.94-2.16) and North region (SMR = 3.10; 2.93-3.27). The same was observed for deaths from hepatic cell carcinomas referenced against Goiânia (SMR = 3.89; 3.66-4.14), Acre State (SMR = 1.79; 1.68-1.91), and the North of Brazil (SMR = 4.04; 3.77-4.30). Among indigenous women, there was an excess of cervical cancer in comparison to Goiânia (SMR = 4.67; 4.41-4.93), Acre State (SMR = 2.12; 2.00-2.24), and the North (SMR = 2.60; 2.45-2.75). The estimates show that preventable neoplasms such as cervical cancer and those linked to underdevelopment, such as stomach and liver cancer, account for 49.4% of deaths among indigenous peoples. Compared to the reference population, mortality from liver, stomach, and colorectal cancer and leukemias was more than twice as high in indigenous men; among indigenous women, cervical, stomach, and liver cancer and leukemias were 30% higher.


El objetivo del estudio fue estimar la mortalidad por cáncer en pueblos indígenas del estado de Acre. Se trata de un estudio observacional descriptivo, a partir del banco de datos nominal del SIM (Sistema de Información Sobre Mortalidad), referente al período de 01 de enero de 2000 a 31 de diciembre de 2012. Se analizó la distribución de frecuencia de óbitos, por sexo y franja de edad, y se calculó la RMP (razón de mortalidad estandarizada), teniendo como referencia Goiânia-GO, Acre y la región norte. Se identificaron 81 óbitos, la mayoría en hombres (59,3%) y por encima de los 70 años. Los cinco principales focos en hombres fueron: estómago, hígado, colon y recto, leucemia y próstata. En las mujeres, cáncer cervical, estómago, hígado, leucemia y útero. En los hombres indígenas, hubo exceso de óbitos por cáncer de estómago, comparados con las poblaciones de Goiânia (RMP = 2,72; 2,58-2,87), estado de Acre (RMP = 2,05; 1,94-2,16) y región norte (RMP = 3,10; 2,93-3,27). Lo mismo se observó en caso de óbitos por hepatocarcinomas, teniendo por referencia Goiânia (RMP = 3,89; 3,66-4,14), estado de Acre (RMP = 1,79; 1,68-1,91) y región norte (RMP = 4,04; 3,77-4,30). Entre las mujeres indígenas, se destaca el exceso de cáncer cervical, en relación con Goiânia (RMP = 4,67; 4,41-4,93), estado de Acre (RMP = 2,12; 2,00-2,24) y región norte (RMP = 2,60; 2,45-2,75). Las estimativas apuntan a que neoplasias susceptibles de prevención, como la cervical, y vinculadas al subdesarrollo, como la de estómago e hígado, correspondieron a cerca de un 49,4% de los óbitos entre indígenas. Comparados con la población de referencia, la mortalidad por cáncer de hígado, estómago, colorrectal y leucemias fue más que el doble entre los hombres indígenas; por cáncer cervical, estómago, hígado y leucemias estuvo por encima de un 30% entre las mujeres indígenas.

12.
Ciênc. Saúde Colet ; 24(1): 261-273, ene. 2019. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-974821

RESUMO

Abstract Breast cancer survival in Latin America countries is below Central European countries. Hospital-based breast cancer survival studies in western Amazon, Brazil, are lacking. This article aims to estimate hospital-based breast cancer survival in Rio Branco, Acre, and predictor factors. Hospital-based cohort study of all women diagnosed with breast cancer (2007-2012) was proceeded. Information were obtained from medical reports, and follow-up was until 2013. One-, 2- and 5- years breast cancer specific-survival were estimated by Kaplan-Meier method. Crude and adjusted Harzards Ratios (HR) were estimated by proportional Cox regression model. One-, 2-, and 5-year overall breast cancer survival were 95.5%, 83.7%, and 87.3% respectively. Surgery combined to radiotherapy significantly affected 1-, 2-, and 5-year survival (99%, 94%, and 90.6%, respectively) as compared to other treatments (77%,57.1%, and 37.5%, respectively). Comparing to surgery combined to radiotherapy treatment, surgery alone increased the risk of death, independently of age and stage (HR = 7.23;95%CI:2.29-22.83). In Rio Branco, Acre, 5-year breast cancer survival is similar to more developed areas in Brazil. Surgery combined to radiotherapy was independently associated to a lower risk of death as compared to surgery alone and other treatment.


Resumo Na América Latina, a sobrevida de 5 anos do câncer de mama está abaixo dos países da Europa central. Não há estudos de sobrevida de câncer de mama de base hospitalar no oeste da Amazônia brasileira. O objetivo deste artigo é estimar a sobrevida hospitalar de câncer de mama e fatores associados em Rio Branco, Acre. Estudo de coorte de base hospitalar com todos os casos de câncer de mama diagnosticados em Rio Branco (2007-2012). As informações foram obtidas de prontuários. As sobrevidas específicas para câncer de mama foram estimadas para 1, 2, e 5 anos pelo método de Kaplan Meier. As hazards ratios (HR) brutas e ajustadas foram estimadas pela regressão proporcional de Cox. As sobrevidas globais em 1, 2 e 5 anos foram respectivamente 95,5%, 83,7%e 87,3%. A cirurgia combinada à radioterapia afetou significativamente a sobrevida em 1, 2 e 5 anos (99%, 94% e 90,6%, respectivamente) quando comparadas a outros tratamentos (77%, 57,1% e 37,5%, respectivamente). Comparadas à cirurgia combinada, as mulheres submetidas à cirurgia isolada apresentaram maior risco de óbito, independentemente da idade e estadiamento (HR = 7,23; 95%CI:2,29-22,83). Em Rio Branco, Acre, a sobrevida em 5 anos para câncer de mama foi elevada. A cirurgia combinada à radioterapia foi independentemente associada ao menor risco de óbito.

13.
Rev. Bras. Saúde Mater. Infant. (Online) ; 18(4): 711-721, Oct.-Dec. 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1013113

RESUMO

Abstract Objectives: this study aimed to describe the epidemiological profile and prevalence of hepatitis B infection in pregnant women living in Rio Branco, Acre, Brazil. Methods: this was a cross-sectional study concerning the prevalence of Hepatitis B in a cohort of women who gave birth in Rio Branco from 2007 to 2015. Data were obtained through health information systems. Pregnant women presenting one or more serological markers or positive molecular biology examination were considered confirmed cases of infections. Infection prevalence, the odds ratio (5% significance) and sociodemographic, clinical, obstetric and neonatal variable frequency distributions were calculated. The student's t-test and Mann Whitney test were applied, as well as the chi-square test or Fisher's exact test, at a significance level of 5%. Results: a total of 62,100 pregnant women were identified for the study period. The prevalence of Hepatitis B in the group was of 0.38% (206 cases), and only 12,5% were diagnosed during the first gestation trimester. A significant difference (p=0.034) in the mean age of infected women was observed when compared to those without infection. The chance of an infected pregnant woman giving birth to a child with a 1st Apgar minute <7 was of 2.01 (CI95%= 1.09-3.71; p=0.995), higher than observed for healthy pregnant woman. Concerning infected patients, the most reported risk exposure was dental treatment (19.2%). Conclusions: the prevalence of Hepatitis B among pregnant women was lower than reported in other national studies. Low Hepatitis B detection during the first gestation trimester was identified, which reinforces the need to intensify early diagnosis during prenatal follow-up, especially due to the severity of the disease and the possibility of vertical transmission.


Resumo Objetivos: descrever o perfil epidemiológico e prevalência da infecção de hepatite B em gestantes residentes em Rio Branco, Acre. Métodos: estudo transversal da prevalência de hepatite B na coorte de mulheres que gestaram em Rio Branco de 2007 a 2015. Os dados foram obtidos através dos sistemas de informação em saúde. Foi considerado caso confirmado de para a infecção a gestante que apresentasse um ou mais marcadores sorológicos ou exame de biologia molecular. Foi calculada a prevalência da infecção, razão de chance (significância de 5%) e distribuição de frequências de variáveis sociodemográficas, clínicas, obstétricas e neonatais. Calculou-se o teste t de Student e Mann Whitney além do teste do qui-quadrado ou exato de Fisher, com significância de 5%. Resultados foram identificadas 62.100 gestantes no período de interesse. A prevalência de hepatite B no grupo foi de 0,38% (206 casos). Destas, apenas 12,5% foram diagnosticadas no 1º trimestre da gestação. Houve diferença significativa (p=0,034) na média de idade das infectadas quando comparadas às sem infecção. A chance de uma gestante infectada ter um filho com Apgar de 1º minuto <7 foi 2,01 (IC95%: 1,09-3,71; p=0,995) vezes maior que uma gestante saudável. Das pacientes infectadas a exposição de risco mais relatada foi o tratamento dentário (19,2%). Conclusões: a prevalência de hepatite B entre gestantes foi inferior à encontrada em outros estudos nacionais. Foi identificada uma baixa detecção de hepatite B no primeiro trimestre gestacional, o que reforça a necessidade de intensificar o diagnóstico precoce durante o seguimento de pré-natal, especialmente pela gravidade da doença e possibilidade da ocorrência de transmissão vertical.


Assuntos
Humanos , Feminino , Gravidez , Perfil de Saúde , Gestantes , Estudos Populacionais em Saúde Pública , Hepatite B/epidemiologia , Primeiro Trimestre da Gravidez , Diagnóstico Pré-Natal , Brasil , Biomarcadores , Distribuição de Qui-Quadrado , Estatísticas não Paramétricas , Transmissão Vertical de Doença Infecciosa , Notificação de Doenças , Detecção Precoce de Câncer
14.
J Glob Oncol ; 4: 1-11, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-30241178

RESUMO

PURPOSE: The incidence of thyroid cancer (TC) has increased substantially worldwide. However, there is a lack of knowledge about age-period-cohort (APC) effects on incidence rates in South American countries. This study describes the TC incidence trends and analyzes APC effects in Cali, Colombia; Costa Rica; Goiânia, Brazil; and Quito, Ecuador. MATERIALS AND METHODS: Data were obtained from the Cancer Incidence in Five Continents series, and the crude and age-standardized incidence rates were calculated. Trends were assessed using the estimated annual percentage change, and APC models were estimated using Poisson regression for individuals between age 20 and 79 years. RESULTS: An increasing trend in age-standardized incidence rates was observed among women from Goiânia (9.2%), Costa Rica (5.7%), Quito (4.0%), and Cali (3.4%), and in men from Goiânia (10.0%) and Costa Rica (3.4%). The APC modeling showed that there was a period effect in all regions and for both sexes. Increasing rate ratios were observed among women over the periods. The best fit model was the APC model in women from all regions and in men from Quito, whereas the age-cohort model showed a better fit in men from Cali and Costa Rica, and the age-drift model showed a better fit among men from Goiânia. CONCLUSION: These findings suggest that overdiagnosis is a possible explanation for the observed increasing pattern of TC incidence. However, some environmental exposures may also have contributed to the observed increase.


Assuntos
Neoplasias da Glândula Tireoide/epidemiologia , Adulto , Idoso , Brasil/epidemiologia , Estudos de Coortes , Colômbia/epidemiologia , Costa Rica/epidemiologia , Equador/epidemiologia , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Sistema de Registros , Adulto Jovem
15.
Mastology (Impr.) ; 28(2): 80-86, abr.-jun.2018.
Artigo em Inglês | LILACS-Express | ID: biblio-965397

RESUMO

Objective: To analyze the incidence of early postoperative complications in women with breast cancer according to the axillary surgery. Methods: An observational study of a cohort of women diagnosed with T1-T2N0M0 clinical stage breast cancer attended at the Brazilian National Cancer Institute from January 2007 to December 2009. The outcome was defined as postsurgical complications in the affected upper limb, such as: axillary web syndrome, winged scapula, paraesthesia and surgical wound, seroma and wound infection. The incidence of simple complications was estimated. The crude and adjusted Odds Ratios, with their respective 95% confidence intervals, were estimated by Multiple Logistic Regression analysis. Results: The incidence of postoperative complications was significantly lower in sentinel lymph node biopsy (axillary web syndrome: 6.0%; paraesthesia: 45.2%; winged scapula: 9.1%; seroma: 28.5%; wound infection: 3.8%) than in axillary lymphadenectomy (axillary web syndrome: 22.5%; paraesthesia: 89.8%; winged scapula: 50.0%; seroma: 69.4%; wound infection: 12.9%). Compared to those who underwent axillary lymphadenectomy, the risk of postoperative complications in those in whom sentinel lymph node biopsy was performed was significantly lower. Conclusion: The sentinel lymph node biopsy technique was an independent protective factor for acute postoperative complications when compared to axillary lymphadenectomy


Objetivo: Analisar a incidência de complicações pós-operatórias precoces em mulheres com câncer de mama de acordo com a cirurgia axilar. Métodos: Estudo observacional de uma coorte de mulheres diagnosticadas com câncer de mama em estágio clínico T1-T2N0M0 atendidas no Instituto Nacional de Câncer do Brasil de janeiro de 2007 a dezembro de 2009. O desfecho foi definido como complicações pós-cirúrgicas no membro superior afetado, tais como: síndrome da rede axilar, escápula alada, parestesia e ferida cirúrgica, seroma e infecção da ferida. A incidência de complicações simples foi estimada. Os Odds Ratios bruto e ajustado, com seus respectivos intervalos de confiança de 95%, foram estimados por análise de Regressão Logística Múltipla. Resultados: A incidência de complicações pós-operatórias foi significativamente menor na biópsia de linfonodo sentinela (síndrome da rede axilar: 6,0%; parestesia: 45,2%; escápula alada: 9,1%; seroma: 28,5%; infecção da ferida: 3,8%) do que na linfadenectomia axilar (síndrome da rede axilar: 22,5%; parestesia: 89,8%; escápula alada: 50,0%; seroma: 69,4%; infecção da ferida: 12,9%). Em comparação com aqueles que foram submetidos a linfadenectomia axilar, o risco de complicações pós-operatórias naqueles nos quais a biópsia de linfonodo sentinela foi realizada foi significativamente menor. Conclusão: A técnica de biópsia de linfonodo sentinela foi um fator de proteção independente para complicações pós-operatórias quando comparadas à linfadenectomia axilar

16.
Rev Saude Publica ; 52: 33, 2018 Apr 09.
Artigo em Inglês, Português | MEDLINE | ID: mdl-29641657

RESUMO

OBJECTIVE: Analyze the trend of infant mortality in Rio Branco, state of Acre, from 1999 to 2015. METHODS: An ecological observational study of a time series, in which data from deaths from the Information System on Mortality and Births of the Information System on Live Births were used. The annual percentage change was estimated using the Joinpoint software. RESULTS: The infant mortality rate decreased from 26.99 in 1999 to 14.50 in 2015 per 1,000 live births, with an annual percentage change of -4.37 (95%CI -5.4- -3.4). When stratified by age components, the neonatal period presented an annual percentage change of -4.73 (95%CI -5.7- -3.7), and the post-neonatal period was -3.7 (95%CI -5.4- -2.0). Avoidability, avoidable causes and poorly defined causes showed a downward trend throughout the period and causes not clearly preventable showed an upward trend until 2008. The group of causes that contributed most to the infant deaths during the period studied was perinatal diseases, followed by malformations, infectious and parasitic diseases, and respiratory diseases. CONCLUSIONS: Despite the decreasing trend in infant mortality rates in the capital compared to developed countries, it is relatively high.


Assuntos
Mortalidade Infantil/tendências , Brasil/epidemiologia , Causas de Morte , Cidades/epidemiologia , Humanos , Lactente , Recém-Nascido , Recém-Nascido Prematuro
17.
Rev. saúde pública (Online) ; 52: 33, 2018. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-903448

RESUMO

ABSTRACT OBJECTIVE Analyze the trend of infant mortality in Rio Branco, state of Acre, from 1999 to 2015. METHODS An ecological observational study of a time series, in which data from deaths from the Information System on Mortality and Births of the Information System on Live Births were used. The annual percentage change was estimated using the Joinpoint software. RESULTS The infant mortality rate decreased from 26.99 in 1999 to 14.50 in 2015 per 1,000 live births, with an annual percentage change of -4.37 (95%CI -5.4- -3.4). When stratified by age components, the neonatal period presented an annual percentage change of -4.73 (95%CI -5.7- -3.7), and the post-neonatal period was -3.7 (95%CI -5.4- -2.0). Avoidability, avoidable causes and poorly defined causes showed a downward trend throughout the period and causes not clearly preventable showed an upward trend until 2008. The group of causes that contributed most to the infant deaths during the period studied was perinatal diseases, followed by malformations, infectious and parasitic diseases, and respiratory diseases. CONCLUSIONS Despite the decreasing trend in infant mortality rates in the capital compared to developed countries, it is relatively high.


RESUMO OBJETIVO Analisar a tendência da mortalidade infantil em Rio Branco, AC, de 1999 a 2015. MÉTODOS Estudo observacional ecológico de série temporal, em que foram utilizados dados de óbitos do Sistema de Informações sobre Mortalidade e Nascimentos do Sistema de Informações sobre Nascidos Vivos. Estimou-se a variação percentual anual por meio do software Joinpoint. RESULTADOS A taxa de mortalidade infantil reduziu de 26,99, em 1999, para 14,50, em 2015, por 1.000 nascidos vivos, com variação percentual anual de -4,37 (IC95% -5,4- -3,4). Quando estratificada por componentes etários, o neonatal apresentou variação percentual anual de -4,73 (IC95% -5,7- -3,7), e o pós-neonatal de -3,7 (IC95% -5,4- -2,0). A evitabilidade, as causas evitáveis e as causas mal definidas apresentaram tendência descendente em todo o período e as causas não claramente evitáveis apresentaram tendência ascendente até 2008. O grupo de causas que mais contribuiu para os óbitos infantis no período estudado foi o das afecções perinatais, seguido pelo das malformações, das doenças infecciosas e parasitárias, e do grupo das doenças respiratórias. CONCLUSÕES Apesar da tendência decrescente da taxa de mortalidade infantil na capital, quando comparada à de países desenvolvidos, mostra-se relativamente elevada.

18.
Rev. saúde pública (Online) ; 52: 33, 2018. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-903509

RESUMO

ABSTRACT OBJECTIVE Analyze the trend of infant mortality in Rio Branco, state of Acre, from 1999 to 2015. METHODS An ecological observational study of a time series, in which data from deaths from the Information System on Mortality and Births of the Information System on Live Births were used. The annual percentage change was estimated using the Joinpoint software. RESULTS The infant mortality rate decreased from 26.99 in 1999 to 14.50 in 2015 per 1,000 live births, with an annual percentage change of -4.37 (95%CI -5.4- -3.4). When stratified by age components, the neonatal period presented an annual percentage change of -4.73 (95%CI -5.7- -3.7), and the post-neonatal period was -3.7 (95%CI -5.4- -2.0). Avoidability, avoidable causes and poorly defined causes showed a downward trend throughout the period and causes not clearly preventable showed an upward trend until 2008. The group of causes that contributed most to the infant deaths during the period studied was perinatal diseases, followed by malformations, infectious and parasitic diseases, and respiratory diseases. CONCLUSIONS Despite the decreasing trend in infant mortality rates in the capital compared to developed countries, it is relatively high.


RESUMO OBJETIVO Analisar a tendência da mortalidade infantil em Rio Branco, AC, de 1999 a 2015. MÉTODOS Estudo observacional ecológico de série temporal, em que foram utilizados dados de óbitos do Sistema de Informações sobre Mortalidade e Nascimentos do Sistema de Informações sobre Nascidos Vivos. Estimou-se a variação percentual anual por meio do software Joinpoint. RESULTADOS A taxa de mortalidade infantil reduziu de 26,99, em 1999, para 14,50, em 2015, por 1.000 nascidos vivos, com variação percentual anual de -4,37 (IC95% -5,4- -3,4). Quando estratificada por componentes etários, o neonatal apresentou variação percentual anual de -4,73 (IC95% -5,7- -3,7), e o pós-neonatal de -3,7 (IC95% -5,4- -2,0). A evitabilidade, as causas evitáveis e as causas mal definidas apresentaram tendência descendente em todo o período e as causas não claramente evitáveis apresentaram tendência ascendente até 2008. O grupo de causas que mais contribuiu para os óbitos infantis no período estudado foi o das afecções perinatais, seguido pelo das malformações, das doenças infecciosas e parasitárias, e do grupo das doenças respiratórias. CONCLUSÕES Apesar da tendência decrescente da taxa de mortalidade infantil na capital, quando comparada à de países desenvolvidos, mostra-se relativamente elevada.

19.
Breast ; 36: 67-73, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28992556

RESUMO

PURPOSE: To evaluate the incidence and risk factors of lymphedema 10 years after surgical treatment for breast cancer. METHODS: Prospective observational hospital-based cohort of women undergoing axillary lymph node dissection. Lymphedema was assessed by indirect volume, measured by circumference, and diagnosed if there was a difference of 200 mL between the arms or if the patient was treated for it. Independent variables were patient, tumour and treatment characteristics. Descriptive statistics were conducted as survival analysis using the Kaplan-Meier estimate. Cox regression was performed, considering a 95% confidence interval (95%CI). RESULTS: The study evaluated 964 women. The cumulative incidence of lymphedema observed was 13.5% at two years of follow-up, 30.2% at five years and 41.1% at 10 years. Final model showed an increased risk for lymphedema among women that underwent radiotherapy (HR = 2.19; 95%CI 1.63-2.94), were obese (HR = 1.52; 95%CI 1.20-1.92), had seroma formation after surgery (HR = 1.46; 95%CI 1.14-1.87), underwent chemotherapy infusion in the affected limb (HR = 1.45; 95%CI 1.12-1.87) or advanced disease staging (HR = 1.41; 95%CI 1.11-1.80). CONCLUSIONS: Cumulative incidence of lymphedema was 41.1%. Women undergoing axillary radiotherapy, obese, who developed seroma, underwent chemotherapy infusion in the affected limb and with advanced disease had a higher risk of lymphedema.


Assuntos
Neoplasias da Mama/cirurgia , Excisão de Linfonodo/efeitos adversos , Linfedema/epidemiologia , Adulto , Idoso , Antineoplásicos/administração & dosagem , Braço , Axila , Neoplasias da Mama/terapia , Quimioterapia Adjuvante , Feminino , Seguimentos , Humanos , Incidência , Infusões Intravenosas , Linfedema/etiologia , Pessoa de Meia-Idade , Obesidade/epidemiologia , Estudos Prospectivos , Radioterapia Adjuvante , Fatores de Risco , Seroma/epidemiologia , Índice de Gravidade de Doença
20.
Cad Saude Publica ; 33(5): e00178915, 2017 Jun 12.
Artigo em Português, Inglês | MEDLINE | ID: mdl-28614453

RESUMO

The effects of dengue infection during pregnancy have not been previously studied in Rio Branco, Acre State, Brazil. The aim of this study was to determine the risks of maternal, fetal, and infant complications resulting from dengue infection during pregnancy. The study compared two cohorts of pregnant women, exposed versus unexposed to dengue virus, from 2007 to 2012. Incidence rates and risk ratios were estimated for maternal, fetal, and infant complications. In the exposed cohort there were 3 fetal deaths and 5 neonatal deaths. Two maternal deaths were identified in the exposed cohort, as opposed to none in the unexposed group (p = 0.040). The exposed cohort showed a risk ratio (RR) of 3.4 (95%CI: 1.02-11.23) for neonatal death. The risk ratio for early neonatal death was 6.8 (95%CI: 1.61-28.75). Ten infant deaths occurred in children of exposed pregnant women and 7 in unexposed (RR = 6.0; 95%CI: 2.24-15.87). Women infected with dengue virus in pregnancy showed increased risk ratio for maternal, neonatal, and infant mortality.


Assuntos
Dengue/complicações , Dengue/mortalidade , Complicações Infecciosas na Gravidez/mortalidade , Complicações Infecciosas na Gravidez/virologia , Adolescente , Adulto , Brasil/epidemiologia , Estudos de Casos e Controles , Estudos de Coortes , Feminino , Morte Fetal , Humanos , Lactente , Recém-Nascido , Mortalidade Materna , Pessoa de Meia-Idade , Morte Perinatal , Gravidez , Estudos Retrospectivos , Fatores Socioeconômicos , Adulto Jovem
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