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1.
Infect Drug Resist ; 14: 4173-4182, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34675562

RESUMO

Objective: Human papillomavirus (HPV) infection, especially with high-risk HPV (HR-HPV) genotypes, is closely associated with cervical cancer. This study aimed to observe the epidemiological characteristics of HPV infection among healthy women in Beijing, China. Materials and Methods: Cervical specimens were collected from 29,436 healthy women, who underwent health check-ups in Peking Union Medical College Hospital between 2016 and 2019. A commercial kit was used for the detection of 15 HR-HPV and two low-risk HPV (LR-HPV) genotypes. Results: A total of 3586 (12.18%) participants tested positive for HPV, 3467 of which were infected with HR-HPVs. The most prevalent genotypes were HPV52, 58, 16, 51, and 56. Moreover, while infection with a single genotype (9.84%) was more prevalent, HPV16+52 was the most common combination in those infected with multiple HPVs. Furthermore, the highest infection rate among age groups was in women aged <25 years (20.92%). No significant difference in the prevalence was observed from 2016 to 2019. However, HPV incidence in Beijing was significantly different than that in all other areas in China, except for Zhengzhou (p < 0.05). Conclusion: Our findings could serve as potential reference for better understanding of the epidemiological characteristics of HPV infection in Beijing.

2.
J Hazard Mater ; 416: 125930, 2021 08 15.
Artigo em Inglês | MEDLINE | ID: mdl-34492860

RESUMO

The pollution of heavy metals and organic compounds has received increased attention in recent years. In the current study, a novel biochar-based iron oxide composite (FeYBC) was successfully synthesized using pomelo peel and ferric chloride solution through one-step process at moderate temperature. Results clearly demonstrate that FeYBC exhibited more efficient removal of Cr(VI) and/or phenol compared with the pristine biochar, and the maximum adsorption amounts of Cr(VI) and phenol by FeYBC could reach 24.37 and 39.32 mg g-1, respectively. A series of characterization data suggests that several iron oxides such as Fe2O3, Fe0, FeOOH and Fe3O4 were formed on the FeYBC surface as well as oxygen-containing groups. Thermodynamics study indicates that Cr(VI) and phenol adsorption by FeYBC were endothermic and exothermic processes, respectively. Langmuir adsorption isotherm and pseudo-second order models could better explain the Cr(VI) and phenol adsorption behaviors over FeYBC. The Cr(VI) adsorption might be primarily achieved through the ion exchange and surface complexation and reduction, whereas the π-π interaction and electron donor-acceptor complex mainly contributed to phenol adsorption. The findings indicate that the biochar-based iron oxide composites material was an efficient adsorbent for the remediation of industrial effluents containing Cr(VI) and phenol.


Assuntos
Poluentes Químicos da Água , Água , Adsorção , Carvão Vegetal , Cromo , Compostos Férricos , Cinética , Fenol , Poluentes Químicos da Água/análise
3.
Zhongguo Gu Shang ; 34(3): 282-7, 2021 Mar 25.
Artigo em Chinês | MEDLINE | ID: mdl-33787176

RESUMO

OBJECTIVE: To observe the analgesic effect of manipulation loading on chronic low back pain (CLBP) model rats and the expression of inflammatory factors in psoas major muscle tissue, and to explore the improvement of manipulation on local inflammatory microenvironment. METHODS: Thirty two SPF male SD rats weighing 340-360g were randomly divided into blank group, sham operation group, chronic low back pain model group and treatment group, with 8 rats in each group. In the model group, L4-L6 lumbar vertebrae were implanted with external link fixation system (ELFS). After implantation of ELFS, the treatment group received manualintervention with 5N force and 2Hz frequency on both sides of the spine, 15 min / time, once a day, for 14 consecutive days. Paw with drawl threshold (PWT) and paw withdrawl latency (PWL) was measured before modeling and on the 1st, 3rd, 7th, 10th and 14th day after intervention. At the end of the treatment cycle, the concentrations of calcitonin gene-related peptide (CGRP) and nerve growth factor (NGF) in psoas muscle were detected by enzyme-linked immunosorbent assay (ELISA). RESULTS: There was no significant difference in PWT and PWL between the blank group and the sham operation group after modeling (P>0.05);after modeling, PWT and PWL in the CLBP model group and the treatment group were significantly decreased(P<0.01);PWT in the treatment group was not significantly improved than that in the CLBP model group on the 1st and 3rd day after manual loading(P>0.05);on the 7th day after manual loading, the pain threshold value in the treatment group was higher than that in the CLBP model group, but there was no significant difference There was no significant difference between the two groups (P=0.056>0.05). On the 10th and 14th day of treatment, the mechanical pain threshold of the treatment group began to rise, and it was statistically significant compared with CLBP model rats (P<0.05, P< 0.01);on the 1st and 3rd day after manual treatment, the PWL of the treatment group was not significantly improved compared with CLBP model group (P>0.05);on the 7th day, the PWL of the treatment group was significantly higher than that of CLBP model group, there was statistical significance (P=0.016<0.05). Manual loading improved thermal hyperalgesia in CLBP rats until the end of the experiment. The contents of CGRP and NGF in psoas major muscle of CLBP model group were higher than those of blank group and sham operation group (P<0.01). After treatment, the contents of CGRP and NGF decreased significantly(P<0.01). CONCLUSION: Local massage loading has analgesic effect on CLBP rats, at the same time, it can inhibit the content of CGRP and NGF in psoas muscle tissue of CLBP rats, and improve the local inflammatory microenvironment.


Assuntos
Peptídeo Relacionado com Gene de Calcitonina , Dor Lombar , Animais , Calcitonina , Dor Lombar/terapia , Masculino , Fator de Crescimento Neural/genética , Ratos , Ratos Sprague-Dawley
4.
Herz ; 46(Suppl 2): 265-271, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33245410

RESUMO

OBJECTIVES: Endothelial dysfunction is involved in various aspects of vascular biology and different stages of cardiovascular diseases (CVDs). Nucleotide-binding oligomerization domain-containing protein (NOD) 2, a pivotal innate immune receptor for muramyl dipeptide (MDP), has been reported to be a central regulator in CVDs. Previously, we reported that NOD2 played a leading role in MDP-triggered oxidative stress in endothelial cells (ECs). However, whether NOD2 participates in the regulatory mechanism of vascular cell adhesion molecule­1 (VCAM-1) and endothelin­1 (ET-1) expression was not elucidated. METHODS: Human umbilical vein endothelial cells (HUVECs) were stimulated with MDP for 12 h. mRNA expression of VCAM­1 and ET­1 was detected using real time polymerase chain reaction (PCR). Scrambled control small interfering RNA (siRNA) and NOD2 siRNA were transfected into HUVECs using Lipofectamine 2000 reagent (Invitrogen, Waltham, MA, USA). Furthermore, pyrrolidine dithiocarbamate was adopted to investigate the effect of nuclear factor κB (NF-κB) on NOD2-mediated VCAM­1 and ET­1 gene expression in MDP-treated HUVECs. RESULTS: Data showed that MDP significantly increased VCAM­1 and ET­1 mRNA expression, which was dependent on NOD2. In addition, NF-κB inhibition suppressed NOD2-mediated gene expression of VCAM­1 and ET­1. CONCLUSION: Collectively, we confirmed NOD2 aggravated VCAM­1 and ET­1 gene expression through NF-κB in HUVECs treated with MDP.


Assuntos
NF-kappa B , Molécula 1 de Adesão de Célula Vascular , Acetilmuramil-Alanil-Isoglutamina/farmacologia , Expressão Gênica , Células Endoteliais da Veia Umbilical Humana/metabolismo , Humanos , NF-kappa B/genética , Proteína Adaptadora de Sinalização NOD2/genética , Proteína Adaptadora de Sinalização NOD2/metabolismo , Molécula 1 de Adesão de Célula Vascular/genética
5.
Opt Express ; 28(16): 23416-23432, 2020 Aug 03.
Artigo em Inglês | MEDLINE | ID: mdl-32752339

RESUMO

A theoretical analysis based on mirror symmetry is proposed to analyze and predict the symmetry in intensity, phase and polarization distributions of the tightly focused vector optical field (VOF). We extend the analysis to more cases including more complicated polarization states and weak focusing cases. We further show the symmetric tightly focused fields of the eccentric cylindrical VOF and the redesigned VOF with a radially variant polarization state, which are achieved by redesigning the polarization state of the incident VOF based on the symmetry analysis. We also take the laser fabrication as an example to further show how to apply this symmetry analysis in a specific application area. Such a theoretical analysis can improve the calculation efficiency, provide new insights into the tight focusing process and offer a convenient way to engineer the field distributions in the focal plane, which may have potential applications in areas needing flexibly controllable tightly focused fields, such as laser fabrication, optical trapping, and optical storage.

6.
Opt Lett ; 45(3): 682-685, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-32004284

RESUMO

Phase memory is an effect in which the interaction between a coherent pump beam and a nonlinear crystal generates photon pairs via the spontaneous parametric down-conversion process, then the down-converted photons (signal and idler) can carry the phase information of the pump beam. There has been much research on the memory of the dynamic phase so far; however, there is no report on the memory of non-dynamic phase, to the best of our knowledge. Here we acquire a Pancharatnam-Berry (PB) geometric phase in a physical system when light travels along a trajectory in polarization-state space. Induced coherence occurs in a cascaded scheme composed of two nonlinear crystals, when the idler photons in both crystals are aligned to be indistinguishable. A NOON ($N\; = \;{2}$N=2) state is established when blocking the two idler photons. We explore the PB geometric phase memory of the NOON state and induced coherence. We find that the first-order interference of the two-photon state or signal photons can be controlled by introducing the PB geometric phase to the pump light. This may facilitate precise control of the phase of the down-converted photons.

7.
Int J Biol Macromol ; 148: 887-897, 2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-31945442

RESUMO

In this study m-AHLPICS (magnetic Arachis hypogaea leaves powder impregnated into chitosan) was prepared and utilized as an adsorbent to remove U(VI) from aqueous and real polluted wastewater samples. m-AHLPICS was characterized by using the BET, XRD, FTIR, SEM with elemental mapping and magnetization measurements. Different experimental effects such as pH, dose, contact time, and temperature were considered broadly. Chitosan modified magnetic leaf powder (m-AHLPICS) exhibits an excellent adsorption capacity (232.4 ± 5.59 mg/g) towards U(VI) ions at pH 5. Different kinetic models such as pseudo-first-order, and pseudo-second-order models were used to know the kinetic data. Langmuir, Freundlich and D-R isotherms were implemented to know the adsorption behavior. Isothermal information fitted well with Langmuir isotherm. Kinetic data followed by the pseudo-second-order kinetics (with high R2 values, i.e., 0.9954, 0.9985 and 0.9971) and the thermodynamic data demonstrate that U(VI) removal using m-AHLPICS was feasible, and endothermic in nature.


Assuntos
Arachis/química , Quitosana/química , Folhas de Planta/química , Urânio/química , Poluentes Radioativos da Água/química , Adsorção , Concentração de Íons de Hidrogênio , Cinética , Pós , Análise Espectral , Temperatura , Termodinâmica , Águas Residuárias , Poluição da Água , Purificação da Água
8.
Int J Biol Macromol ; 149: 127-139, 2020 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-31978476

RESUMO

Uranium (U(VI)) is radioactive and the primary raw material in the production of nuclear energy. Hence the research associated with uranium removal gained a lot of importance because to reduce the threat of uranium contamination to ecology and its environment surroundings. Thus, economically as well as environmentally friendly sorbents with a good sorption capacity have to be acquired for the removal of U(VI) pollutants from the aqueous and polluted sea samples. In this study magnetic- Momordica charantia leaf powder impregnated into chitosan (m-MCLPICS) was prepared through the impregnation method. After preparation the adsorbent undergone through various characterizations such as BET, XRD, FTIR, SEM with elemental mapping, and VSM analysis. The specific surface area (93.12 m2/g), pore size (0.212 cm3/g) and pore volume (15.35 nm) of m-MCLPICS was obtained from the BET analysis. A pH value of 5 and 0.5 g of adsorbent dose were selected as an optimum values for U(VI) removal. Kinetic data follows the pseudo-second-order model, and the equilibrium data fitted well with the Langmuir isotherm model. ΔG° (-1.6999, -2.4994, -3.5476 and -4.5147 kJ/mol), ΔH0 (25.1 kJ/mol) and ΔS0 (0.089 kJ/mol K) indicates that the U(VI) sorption process is feasible, spontaneous and endothermic.


Assuntos
Quitosana/química , Momordica charantia/química , Folhas de Planta/química , Urânio/química , Poluentes Radioativos da Água/química , Purificação da Água , Pós , Águas Residuárias/química
9.
J Hazard Mater ; 384: 121385, 2020 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-31606253

RESUMO

Recently, clean-up of resistant organic compounds has attracted growing attention. In this study, a novel heterogeneous ultrasound-enhanced sludge biochar catalyst/persulfate (BC/PS/US) process was firstly developed for the degradation of bisphenol A (BPA) in water. The results revealed that BC/PS/US process could successfully achieve a positively synergistic effect between sonochemistry and catalytic chemistry on the degradation of BPA compared to its corresponding comparative process. Nearly 98% of BPA could be degraded within 80 min at optimum reaction conditions. The coexisting substances including Cl-, SO42- and NO3- had no obvious inhibition on the BPA degradation, whereas HCO3- and humic acid (HA) had significant inhibition effects on that. PS decomposition of BC/PS/US process was superior to that of BC/PS or US/PS process. Both SO4- and HO participated in the degradation of BPA, but SO4- was predominant radical in the BC/PS/US process. A possible pathway of BPA degradation was proposed, and the BPA molecule was attacked by SO4- and degraded into five kinds of intermediate products through hydroxylation and demethylation processes. This study helps to comprehend the application of sludge biochar catalyst as a persulfate activator for the degradation of organic compounds under ultrasound irradiation, and provides a new strategy in wastewater treatment.


Assuntos
Compostos Benzidrílicos/análise , Carvão Vegetal/química , Fenóis/análise , Esgotos/química , Compostos de Sódio/química , Sulfatos/química , Ondas Ultrassônicas , Poluentes Químicos da Água/análise , Purificação da Água/métodos , Catálise , Oxirredução , Águas Residuárias/química
10.
Sci Adv ; 5(6): eaat9206, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31214646

RESUMO

High-dimensional Bell-like states are necessary for increasing the channel capacity of the quantum protocol. However, their preparation and measurement are still huge challenges, especially for the latter. Here, we prepare an initial eight-dimensional Bell-like state based on hyperentanglement of spin and orbital angular momentum (OAM) of the first and the third orders. We design simple unitary operations to produce eight Bell-like states, which can be distinguished completely in theory among each other. We propose and illustrate a multiple projective measurement scheme composed of only linear optical elements and experimentally demonstrate that all the eight hyperentangled Bell-like states can be completely distinguished by our scheme. Our idea of manipulating the eight Bell-like states is beneficial to achieve the 3-bit channel capacity of quantum protocol, opening the door for extending applications of OAM states in future quantum information technology.

11.
Int J Biol Macromol ; 136: 177-188, 2019 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-31173826

RESUMO

It is well-known that heavy metals are non-biodegradable and have been showing remarkable impacts on the environment, public health and economics. Because of high toxic tendency, lead (Pb), is one of the foremost considerable hazardous metal with high environmental impacts. Chitosan is a polysaccharide, and can be utilized in wastewater treatment because of its good sorption ability. Amino and hydroxyl groups (C-3 position) on chitosan can serve as electrostatic interaction and complexation sites for metal cations. Chemical crosslinking can effectively enhance the stability of chitosan in acidic media. Hence a novel, cost-effective and eco-friendly ZnO incorporated into aminated chitosan Schiff's base (ACSSB@ZnO) has been synthesized, characterized (BET, XRD, FTIR, SEM, TEM and 1H NMR), and utilized as an adsorbent for the removal of Pb(II) ions from the aqueous environment. The various operating parameters, such as pH (2-8), agitation speed (30-180), adsorbent dose (0.1-0.8 g), contact time (0-140 min), metal ion concentration and temperature (303-323 K) were investigated. The maximum sorption capacity of Pb(II) onto ACSSB@ZnO was found to be 55.55 mg/g. The equilibrium, and kinetic studies suggested that the adsorption process followed the Langmuir isotherm and Pseudo-Second-Order model. Thermodynamic data showed that the sorption process was feasible, spontaneous, and endothermic.


Assuntos
Quitosana/química , Chumbo/química , Chumbo/isolamento & purificação , Poluentes Químicos da Água/química , Poluentes Químicos da Água/isolamento & purificação , Purificação da Água/métodos , Água/química , Adsorção , Concentração de Íons de Hidrogênio , Cinética , Bases de Schiff/química , Eletricidade Estática , Temperatura , Óxido de Zinco/química
12.
Opt Lett ; 44(9): 2382-2385, 2019 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-31042228

RESUMO

We design and realize a generator that can convert an orbital angular momentum (OAM) state into a vector polarization state. The generator is integrated by several commonly used optical elements and easy to make or glued. Compared with traditional interferometric ways for generating the vector optical fields, this integrated generator has compact and robust advantages and especially a high-efficiency of 87%.

13.
Chemosphere ; 221: 511-518, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30660907

RESUMO

In this study, the feasibility of a novel Ca-Ag3PO4 composite with visible light irradiation for the phenanthrene (PHE) degradation and algae inactivation in artificial seawater was firstly investigated. The experimental findings revealed that Ag3PO4 phase was sucessfully formed on the Ca-based material, and the presence of Ca-based material could effectively keep Ag3PO4 particles stable. An excellent performance on PHE degradation or algae inactivation was observed from Ca-Ag3PO4 composite under visible light irradiation. The degradation of PHE or inactivation of algae not only could be efficiently achieved in the single mode, but also could be successfully achieved in the coexisting mode. Above 96% of PHE and algae were simultaneously removed within 12 h in the Ca-Ag3PO4/visible light system. It was further observed that the degradation of PHE and/or inactivation of algae increased with the increase of Ca-Ag3PO4 dosage. HO was the primary radical responsible for PHE degradation, whereas HO and Ag+ released from Ca-Ag3PO4 mainly contributed to the algae inactivation. A possible mechanism involving the catalytic removal of PHE and algae by Ca-Ag3PO4 under visible light irradiation was proposed. This study provides helpful guide for the simultaneous removal of various pollutants in real seawater.


Assuntos
Luz , Fenantrenos/química , Fosfatos/farmacologia , Alga Marinha/efeitos da radiação , Compostos de Prata/farmacologia , Cálcio , Catálise/efeitos dos fármacos , Catálise/efeitos da radiação , Água do Mar/química , Poluentes da Água/química , Poluentes da Água/efeitos da radiação , Purificação da Água/métodos
14.
Sci Total Environ ; 660: 541-549, 2019 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-30641381

RESUMO

Herein, the application of a novel acid mine drainage-based nanoscale zero valent iron (AMD-based nZVI) for the remediation of nitrate and norfloxacin (NOR) was studied. Experimental results indicated that the catalytic reactivity of AMD-based nZVI toward nitrate reduction was superior to that of iron salt-based nanoscale zero valent iron (Iron salt-based nZVI). The presence of ultrasound irradiation could significantly enhance the reactivity toward both the nitrate reduction and NOR oxidation processes. The optimal efficiencies of nitrate and NOR by AMD-based nZVI/US process could be kept 96 and 94% within 120 min, respectively. Ammonia was identified as a major product in nitrate reduction process, while three oxidation products were observed in NOR degradation process. Both reduction reaction of nitrate from AMD-based nZVI and oxidation reaction of NOR from US-assisted Fenton system might be involved in AMD-based nZVI/US process. The AMD-based nZVI/US process showed a better performance on the removal of NOR compared with that of nitrate. The findings of the present work could be as a guide and show that AMD-based nZVI/US process is feasible for the remediation of both nitrate and NOR in real wastewater.


Assuntos
Antibacterianos/análise , Ferro/química , Nanopartículas Metálicas/química , Nitratos/química , Norfloxacino/análise , Poluentes Químicos da Água/análise , Oxirredução
15.
Sci Total Environ ; 642: 505-515, 2018 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-29908509

RESUMO

Cr6+ and Pb2+ are both highly toxic pollutants and commonly co-exist in some industrial effluents and contaminated waters. In this study, simultaneous removal of Cr6+ and Pb2+ by a novel sewage sludge-derived biochar immobilized nanoscale zero-valent iron (SSB-nZVI) was systematically investigated. It was well demonstrated that a porous structure was successfully formed on the SSB-nZVI when the starch was used as an additive. A synergistic effect on the adsorption and reduction over the SSB-nZVI was achieved, resulting in nearly 90 and 82% of Cr6+ and Pb2+ removal within 30 min, respectively. Cr6+ was reduced prior to Pb2+. A low pH could accelerate the corrosion of nZVI as well as phosphate leaching. When Malachite green was added as a coexisting organic pollutant, its effective removal was found due to the formation of a Fenton-like system. The SSB-nZVI could be run consecutively three times with a relatively satisfactory performance. Most of Cr6+ was converted into Cr2O3 and Cr(OH)3 on the SSB-nZVI surface, whereas most of Pb2+ species existed as Pb(OH)2 (or PbO). A possible reaction mechanism on the SSB-nZVI involved the adsorption, reduction and precipitation of both Cr6+ and Pb2+ over the particles. Present study sheds light on the insight of the fate and transport of Cr6+ and Pb2+ in aquatic environment, as well provides helpful guide for the remediation of coexistence of pollutants in real applications.


Assuntos
Cromo/análise , Ferro/análise , Chumbo/análise , Eliminação de Resíduos Líquidos/métodos , Poluentes Químicos da Água/análise , Carvão Vegetal , Cromo/química , Ferro/química , Chumbo/química , Esgotos , Poluentes Químicos da Água/química
16.
Environ Pollut ; 239: 698-705, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29715689

RESUMO

In this study, a novel biochar-supported zero valent iron (BC-nZVI) was synthesized through a green method. A high performance on the simultaneous removal of Cu2+ and bisphenol A (BPA) by a combination of BC-nZVI with persulfate (BC-nZVI/PS) system was successfully achieved. The simultaneous efficiencies of Cu2+ and BPA could reach 96 and 98% within 60 min, respectively. Both HO• and SO4•- were two major reactive species in BC-nZVI/PS system, and SO4•- was primary radical responsible for the degradation of BPA. Four kinds of Cu species, such as Cu(OH)2, CuO, Cu2O and Cu0 were generated via the adsorption and reduction of the BC-nZVI, whereas six kinds of products of BPA including p-isopropenyl phenol and 4-isopropylphenol were generated via the combined oxidation of SO4•- and HO•. The possible reaction mechanism for the simultaneous removal of Cu2+ and BPA by BC-nZVI/PS system contained a synergistic effect between the reduction of Cu2+ and the oxidation of BPA. This is the first report on the feasibility of the remediation of coexistence of heavy metal and organic compound in aquatic environment using the BC-nZVI/PS system.


Assuntos
Compostos Benzidrílicos/análise , Carvão Vegetal/química , Cobre/análise , Ferro/química , Fenóis/análise , Poluentes Químicos da Água/análise , Adsorção , Compostos Benzidrílicos/química , Cátions Bivalentes , Cobre/química , Oxirredução , Fenóis/química , Poluentes Químicos da Água/química
17.
J Cardiovasc Pharmacol ; 71(6): 352-358, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29634657

RESUMO

Vascular endothelium dysfunction caused by oxidative stress accelerates the pathologic process of cardiovascular diseases. NOD2, an essential receptor of innate immune system, has been demonstrated to play a critical role in atherosclerosis. Here, the aim of our study was to investigate the effect and underlying molecular mechanism of muramyl dipeptide (MDP) on NOX4-mediated reactive oxygen species (ROS) generation in human umbilical vein endothelial cells (HUVECs). The 2,7-dichlorofluorescein diacetate staining was to measure the intracellular ROS level and showed MDP-promoted ROS production in a time- and dose-dependent manner. The mRNA and protein levels of NOX4 and COX-2 were detected by real-time polymerase chain reaction and western blot. Small interfering RNA (siRNA) was used to silence NOD2 or COX-2 gene expression and investigate the mechanism of NOD2-mediated signaling pathway in HUVECs. Data showed that MDP induced NOX4 and COX-2 expression in a time- and dose-dependent manner. NOD2 knock-down suppressed upregulation of COX-2 and NOX4 in HUVECs treated with MDP. Furthermore, silence of COX-2 in HUVECs downregulated the NOX4 expression after MDP stimulation. Collectively, we indicated that NOD2 played a leading role in MDP-induced COX-2/NOX4/ROS signaling pathway in HUVECs, which was a novel regulatory mechanism in the progress of ROS generation.


Assuntos
Acetilmuramil-Alanil-Isoglutamina/farmacologia , Ciclo-Oxigenase 2/metabolismo , Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos , NADPH Oxidase 4/metabolismo , Proteína Adaptadora de Sinalização NOD2/metabolismo , Oxidantes/farmacologia , Estresse Oxidativo/efeitos dos fármacos , Espécies Reativas de Oxigênio/metabolismo , Células Cultivadas , Ciclo-Oxigenase 2/genética , Relação Dose-Resposta a Droga , Células Endoteliais da Veia Umbilical Humana/enzimologia , Humanos , NADPH Oxidase 4/genética , Proteína Adaptadora de Sinalização NOD2/genética , Transdução de Sinais/efeitos dos fármacos , Fatores de Tempo
18.
Cancer Chemother Pharmacol ; 81(6): 1007-1015, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29619507

RESUMO

PURPOSE: This study is a retrospective analysis evaluating the efficacy and toxicity of combination chemotherapy with Paclitaxel (PTX) and Oxaliplatin (OXA) as first-line treatment for patients with advanced gastric cancer (AGC). METHODS: One hundred and seven patients with locally advanced or metastatic gastric adenocarcinoma received intravenous infusions of PTX at 135 mg/m2 and OXA at 85 mg/m2 on day 1 every 14 days. RESULTS: Among 107 patients enrolled, 9 patients could not be evaluated for a response because of the absence of any measurable lesions. Assessment of the response of 98 patients was made. The overall objective response rate was 42.9% (95% CI 32.9-52.8%), with two complete responses and 40 partial responses. The disease control was 79.6% (95% CI 71.5-87.7%). With 29 months of the median time of follow-up, the median progression-free survival was 5.8 months (95% CI 4.30-7.30 months) and the median overall survival was 11.5 months (95% CI 9.08-13.9 months). The 1-year survival rate was 48.0%. The most common grades 3 and 4 toxicities included neutropenia (32.7%), leucopenia (17.8%), fatigue (5.61%), and anemia (4.67%). Peripheral neuropathy occurred in 23.4% patients and grade 2 or higher peripheral neuropathy occurred in 12.1% of the patients. CONCLUSIONS: Combination chemotherapy with PTX and OXA offers a new, effective and safe regimen for patients with advanced gastric cancer.


Assuntos
Adenocarcinoma/tratamento farmacológico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Gástricas/tratamento farmacológico , Adenocarcinoma/patologia , Adulto , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Intervalo Livre de Doença , Feminino , Humanos , Infusões Intravenosas , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Oxaliplatina/administração & dosagem , Paclitaxel/administração & dosagem , Estudos Retrospectivos , Neoplasias Gástricas/patologia , Taxa de Sobrevida , Adulto Jovem
19.
J Colloid Interface Sci ; 525: 225-233, 2018 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-29704782

RESUMO

Highly efficient removal of dye pollutants from water resources remains a great challenge. Herein, we demonstrate a new approach for the efficient removal of anionic organic dyes from wastewater using shape-dependent CeO2 nanostructures. It was found that the volume stoichiometry ratio of ethanol to water (EtOH/H2O) was a key factor affecting the CeO2 nanostructures. Accordingly, the adsorption capacity of the spindle CeO2 nanostructure for Congo red reached 162.4 mg g-1, which is much higher than that of octahedral and spherical CeO2 or other adsorbents previously reported. The superior adsorption performance may be mainly attributed to the peculiar structure and presence of electrostatic interactions between the sample surface and dye molecules. This finding will provide new avenues for using promising adsorbent materials for dye removal in water treatments.

20.
Sci Rep ; 8(1): 5140, 2018 03 23.
Artigo em Inglês | MEDLINE | ID: mdl-29572509

RESUMO

We present a quantitative method, utilising a highly sensitive quantum sensor, that extends applicability of magnetorelaxometry to biological samples at physiological temperature. The observed magnetic fields allow for non-invasive determination of physical properties of magnetic materials and their surrounding environment inside the specimen. The method is applied to American cockroaches and reveals magnetic deposits with strikingly different behaviour in alive and dead insects. We discuss consequences of this finding to cockroach magneto-reception. To our knowledge, this work represents the first characterisation of the magnetisation dynamics in live insects and helps to connect results from behavioural experiments on insects in magnetic fields with characterisation of magnetic materials in their corpses.


Assuntos
Comportamento Animal/fisiologia , Campos Magnéticos , Orientação/fisiologia , Periplaneta , Animais , Feminino , Masculino , Periplaneta/anatomia & histologia , Periplaneta/metabolismo
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