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1.
Chem Soc Rev ; 49(18): 6579-6591, 2020 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-32789318

RESUMO

Solar-driven reduction of CO2 into fuels/feedstocks is a promising strategy for addressing energy and CO2 emission issues. Despite great research efforts, it still remains a grand challenge to achieve efficient and highly selective reduction of CO2 owing to the large bond energy of CO2 and the diversity of reduction products. In addition to the control of light harvesting and charge transfer like photocatalytic water splitting, the design of catalytically active sites is highly important to promote CO2 reduction activity and selectivity (e.g., C-C coupling). In fact, we can learn a lot from conventional CO2 hydrogenation and syngas conversion in terms of active site design. In this article, we demonstrate how to design catalytically active sites for efficient and highly selective photocatalytic reduction of CO2 by sorting out the rules from the existing research on conventional COx hydrogenation, with a focus on enhancing C[double bond, length as m-dash]O activation and C-C coupling to form value-added products. This article aims to highlight the challenges in the field of photocatalytic CO2 conversion and the connection of photocatalysis with conventional catalytic systems, providing the readers the opportunities to join the research.

2.
Leg Med (Tokyo) ; 47: 101741, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32682294

RESUMO

In present study, we evaluated the genetic diversities of 30 insertion/deletion (InDel) loci and analyzed the genetic relationships between Daur and other comparison populations. In the studied Daur group, any two InDel loci showed no linkage disequilibrium, and all loci showed no deviations from exact tests of Hardy-Weinberg equilibrium. Insertion allele frequencies at 30 InDel loci ranged from 0.1459 (HLD39) to 0.8774 (HLD118). The observed heterozygosity and expected heterozygosity values were ranged from 0.1984 (HLD118) to 0.5564 (HLD6) and 0.2155 (HLD118) to 0.5000 (HLD92 and HLD6), respectively. The combined power of discrimination and power of exclusion values were 0.999999999993428 and 0.9878, respectively, which indicated that this panel of 30 InDels could be used for individual identifications in Daur group. Population genetic analyses including pairwise fixation index, STRUCTURE analysis, principal component analysis, genetic distance, multidimensional scaling analysis and phylogenetic analysis demonstrated that the Daur group had the closer genetic relationships with the groups from western China in comparison with other continental populations.

3.
Zhen Ci Yan Jiu ; 45(4): 305-9, 2020 Apr 25.
Artigo em Chinês | MEDLINE | ID: mdl-32333536

RESUMO

OBJECTIVE: To observe the effect of moxibustion and acupoint catgut embedding (ACE) at "Tianshu"(ST25) "Dachangshu"(BL25) and "Shangjuxu"(ST37) on changes of body mass, stool property, histopathological conditions and expression levels of interleukin 6 (IL-6) in colonic mucosa of ulcerative colitis (UC) rats, so as to reveal its anti-inflammatory mechanisms underlying improvement of UC. METHODS: SD rats were randomized into normal, model, moxibustion, ACE and moxibustion+ACE groups (n=6 in each group). The UC model was established by enema of trinitro-benzene-sulfonic acid and ethanol. Moxibustion was applied to bilateral ST25, BL25 and ST37 for 10 min, once daily for 14 days, and ACE applied to the same 3 acupoints, once a week for two weeks. After the treatment, the rats' general conditions were observed, and the severity of UC was assessed by using disease activity index (DAI) score. Colonic mucosal pathological changes were observed under microscope after hematoxylin eosin (H.E.) stain, and the expression levels of IL-6 in the colonic mucosa tissue detected by using immunohistochemical stain and Western blot, respectively. RESULTS: After modeling, the DAI score, and expression level of colonic IL-6 protein detected by immunohistochemistry and Western blot were obviously increased in the model group relevant to the normal group (P<0.01). Following the intervention, the increase of DAI score and IL-6 expression were reversed in moxibustion, ACE and moxibustion+ACE groups (P<0.01, P<0.05). The therapeutic effects of moxibustion+ACE were considerably superior to those of simple ACE and simple moxibustion in down-regulating the levels of DAI score and IL-6 expression (P<0.01). H.E. staining showed severe defect of the colonic mucosal epithelium with infiltration of a large number of inflammatory cells in the model group, which was milder in moxibustion, ACE and moxibustion+ACE groups. CONCLUSION: Moxibustion combined with ACE is able to improve the inflammatory injury of colonic mucosa in UC rats, which may be related with its effect in suppressing the expression of colonic IL-6; and the efficacy of moxibustion+ACE is apparently superior to that of moxibustion and ACE alone.


Assuntos
Colite Ulcerativa , Moxibustão , Pontos de Acupuntura , Animais , Categute , Inflamação , Ratos , Ratos Sprague-Dawley
4.
BMC Mol Cell Biol ; 21(1): 13, 2020 Mar 11.
Artigo em Inglês | MEDLINE | ID: mdl-32160867

RESUMO

BACKGROUND: Alzheimer's disease is the most common neurodegenerative disease in the elderly. Amyloid-ß protein (Aß) is the major component of neuritic plaques which are the hallmark of AD pathology. ß-site APP cleaving enzyme 1 (BACE1) is the major ß-secretase contributing to Aß generation. ß-site APP-cleaving enzyme 2 (BACE2), the homolog of BACE1, might play a complex role in the pathogenesis of Alzheimer's disease as it is not only a θ-secretase but also a conditional ß-secretase. Dysregulation of BACE2 is observed in Alzheimer's disease. However, the regulation of BACE2 is less studied compared with BACE1, including its degradation pathways. In this study, we investigated the turnover rates and degradation pathways of BACE2 in both neuronal cells and non-neuronal cells. RESULTS: Both lysosomal inhibition and proteasomal inhibition cause a time- and dose-dependent increase of transiently overexpressed BACE2 in HEK293 cells. The half-life of transiently overexpressed BACE2 protein is approximately 6 h. Moreover, the half-life of endogenous BACE2 protein is approximately 4 h in both HEK293 cells and mouse primary cortical neurons. Furthermore, both lysosomal inhibition and proteasomal inhibition markedly increases endogenous BACE2 in HEK293 cells and mouse primary cortical neurons. CONCLUSIONS: This study demonstrates that BACE2 is degraded by both the proteasome and lysosome pathways in both neuronal and non-neuronal cells at endogenous level and in transient overexpression system. It indicates that BACE2 dysregulation might be mediated by the proteasomal and lysosomal impairment in Alzheimer's disease. This study advances our understanding of the regulation of BACE2 and provides a potential mechanism of its dysregulation in Alzheimer's disease.

5.
Chem Rev ; 2020 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-32186373

RESUMO

Single-atom photocatalysts have shown their compelling potential and arguably become the most active research direction in photocatalysis due to their fascinating strengths in enhancing light-harvesting, charge transfer dynamics, and surface reactions of a photocatalytic system. While numerous comprehensions about the single-atom photocatalysts have recently been amassed, advanced characterization techniques and vital theoretical studies are strengthening our understanding on these fascinating materials, allowing us to forecast their working mechanisms and applications in photocatalysis. In this review, we begin by describing the general background and definition of the single-atom photocatalysts. A brief discussion of the metal-support interactions on the single-atom photocatalysts is then provided. Thereafter, the current available characterization techniques for single-atom photocatalysts are summarized. After having some fundamental understanding on the single-atom photocatalysts, their advantages and applications in photocatalysis are discussed. Finally, we end this review with a look into the remaining challenges and future perspectives of single-atom photocatalysts. We anticipate that this review will provide some inspiration for the future discovery of the single-atom photocatalysts, manifestly stimulating the development in this emerging research area.

6.
Biomed Res Int ; 2020: 3925189, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31998787

RESUMO

Insertion/deletion (InDel) markers have been treated as a prospective and helpful aid in the fields of forensic human identifications and biogeography origin researches for the past few years. In this study, we analyzed genetic polymorphisms and forensic efficiencies of 35 InDels in a novel multiplex PCR-InDel panel in a Chinese Mongolian group. All these 35 InDel loci were observed to conform to Hardy-Weinberg equilibrium and linkage equilibrium. The mean values of expected heterozygosity and observed heterozygosity were 0.4788 and 0.4852, respectively. Besides, the interpopulation differentiations and genetic distributions based on 35 InDels found that the Chinese Mongolian group might have closer genetic relationships and similar population genetic structures with East Asian populations.


Assuntos
Grupo com Ancestrais do Continente Asiático , Mutação INDEL , Polimorfismo Genético , Grupo com Ancestrais do Continente Asiático/etnologia , Grupo com Ancestrais do Continente Asiático/genética , China/etnologia , Feminino , Marcadores Genéticos , Humanos , Masculino , Reação em Cadeia da Polimerase Multiplex
7.
Electrophoresis ; 41(3-4): 235-245, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31743462

RESUMO

A biogeographic estimate of a certain population can not only discern population substructure in the whole genome association study, but also provide informative clues for forensic investigations when obtained DNA genotypes do not find a match in the available forensic DNA database. In this study, 100 ancestry informative single nucleotide polymorphisms (AISNPs) were first presented to differentiate three continental ancestries (African, East Asian and European). Ultimately, forty-two AISNPs were chosen from the 100 AISNPs. Distinguishing power of the 100 and 42 AISNPs for differentiating continental populations was further evaluated with population cluster analyses. Results indicated both of AISNP sets could efficiently differentiate 11 training populations from the three continents. Further validation of 42 AISNPs in testing population set indicated these 42 AISNPs performed well for ancestry inferences of these testing individuals. Ancestry components of Uyghur group were assessed by comparing with different continental populations based on these 42 AISNPs. Results revealed that East Asian populations contributed more ancestry components to the studied Uyghur group than European populations. In conclusion, our study is expected to provide more AISNP markers and enrich extant reference database.

8.
Mol Biol Rep ; 47(2): 1079-1087, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31792748

RESUMO

Tibetans living in the Qing-Tibet plateau show unique genetic features since they are exposed to the high altitude environment. Accordingly, it is necessary for us to analyze genetic components of the Tibetan groups. Here, genetic structure and ancestry proportions of Tibet Tibetan and Qinghai Tibetan groups are dissected by using a previously published ancestral deletion/insertion polymorphisms (DIPs) panel. Genetic distributions of the analyzed DIPs in both Tibetan groups reveal that some DIPs show relatively balanced frequency distributions with the values ranging from 0.4 to 0.6, implying that these DIPs could be used as individual identification loci for forensic applications in both groups. Besides, the cumulative power of discrimination of the panel also reflects that the panel could serve as a valuable tool for forensic individual identifications in Tibet Tibetan and Qinghai Tibetan groups. Population genetic analyses including principal component analysis, DA genetic distances, phylogenetic tree, and genetic structure reveal that two studied Tibetan groups have closer genetic affiliations with East Asian populations. Genetic differentiation analyses of two Han populations, Xinjiang Uyghur and two Tibetan groups reveal that some DIP loci might be informative for differentiating Uyghurs from the other populations.

9.
Cell Prolif ; 53(1): e12713, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31691382

RESUMO

OBJECTIVES: Carbon dots (CDs), as a fascinating class of fluorescent carbon nanomaterials, have been proven to be powerful tools in the field of bioimaging and biosensing due to their small size, suitable photostability and favourable biocompatibility. However, the cellular uptake of free CDs lacks selectivity and the same negative charges as cell membranes may cause inefficient cell internalization. In this study, an efficient detecting and targeting nanosystem was developed based on the DNA aptamer AS1411 modified CDs with polyethyleneimine (PEI) as connecting bridge. MATERIALS AND METHODS: Hydrothermally prepared CDs were assembled with positive-charged PEI, followed by conjugation with AS1411 through electrostatic interaction to form CDs-PEI-AS1411 nanocomplexes. The CDs, CDs-PEI and CDs-PEI-AS1411 were characterized by transmission electron microscopy (TEM), fourier transform infrared (FTIR) spectra, UV-vis spectra, zeta potential measurements and capillary electrophoresis characterizations. The cytotoxicity investigation of the CDs-PEI-AS1411 and CDs-PEI in both MCF-7 and L929 cells was carried out by the CCK-8 assay. The cellular uptake of the CDs-PEI-AS1411 was studied with confocal microscopy and flow cytometry. RESULTS: The as-prepared nanosystem possessed good photostability and no obvious cytotoxicity. On the basis of the confocal laser scanning microscope observation and the flow cytometry studies, the cellular uptake of CDs-PEI-AS1411 nanosystem in MCF-7 cells was significantly higher than that of L929 cells, which revealed the highly selective detection ability of nucleolin-positive cells. CONCLUSIONS: The results of this study indicated that the CDs-PEI-AS1411 nanosystem had a potential value in cancer cell targeted imaging.


Assuntos
Aptâmeros de Nucleotídeos , Sistemas de Liberação de Medicamentos , Citometria de Fluxo , Neoplasias , Oligodesoxirribonucleotídeos , Pontos Quânticos/química , Aptâmeros de Nucleotídeos/química , Aptâmeros de Nucleotídeos/farmacocinética , Aptâmeros de Nucleotídeos/farmacologia , Carbono/química , Carbono/farmacocinética , Carbono/farmacologia , Humanos , Células MCF-7 , Microscopia Confocal , Neoplasias/diagnóstico por imagem , Neoplasias/metabolismo , Oligodesoxirribonucleotídeos/química , Oligodesoxirribonucleotídeos/farmacocinética , Oligodesoxirribonucleotídeos/farmacologia , Polietilenoimina/química , Polietilenoimina/farmacocinética , Polietilenoimina/farmacologia
10.
J Nanosci Nanotechnol ; 20(2): 673-679, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-31383062

RESUMO

A proper soft tissue seal between implants and gingiva is critical for success of dental implants. Implant surface modification is an important approach for achieving ideal host-implant integration. In this study, we used a new and simple oxidation method to generate a rough surface on implants at the nano scale, which oxidized titanium nano-foveolae (TiNF) surface. We further analyzed the surface topography and tested its effects on biological activities of human gingival fibroblasts. Atomic force microscopy (AFM) and scanning electron microscopy (SEM) examination demonstrated that TiNF disks displayed uniform rough surfaces, with average TiNF diameters of approximately 60 nm and 100 nm respectively. However, the surfaces of smooth samples were highly irregular, and cell adhesion and proliferation rates on TiNF surfaces were significantly higher than those of the smooth surfaces. Extracellular matrix synthesis was also increased in the cells that interacted with oxidized TiNF surfaces. Altogether, these results suggest that the TiNF implant surfaces perform better for human gingival fibroblast biological activities compared to traditional smooth surfaces. Therefore, the TiNF implant surfaces may serve as ideal interface to facilitate implant-host integration.

11.
Mol Genet Genomic Med ; 8(2): e1074, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31865639

RESUMO

BACKGROUND: Individual identification is one of the most important tasks in the field of forensic genetics. Insertion/Deletion (InDel) polymorphism marker has been a promising marker for individual identification. However, a part of InDel loci in commonly used commercial kit show low polymorphisms in Chinese populations. METHODS: We evaluated a panel of 35 InDel loci constructed previously for individual identifications in Hui group. Subsequently, population data of three Chinese populations from 1,000 Genomes Project database were used to evaluate individual identification performance of these 35 InDels. Forensic parameters, such as heterozygosity, power of exclusion, match probability and power of discrimination, were calculated to evaluate the forensic efficiency of these loci in Hui group. The heatmap of insertion allelic frequencies, Nei's genetic distances, pairwise fixation index values, principal component analyses and admixture analyses were used to analyze the genetic differentiations and structure between Hui group and other populations. RESULTS: In studied Hui group, besides rs3054057, polymorphism information content values of the remaining loci were greater than 0.3. Values of expected heterozygosity of these loci were close to 0.5. The combined power of discrimination and power of exclusion values were 0.99999999999999659609 and 0.998682, respectively. Analyses of population genetics revealed that Chinese Hui group had closer genetic relationships with East Asian populations than other intercontinental populations. CONCLUSION: The forensic statistical analyses revealed these loci showed relatively high genetic polymorphisms in Chinese Hui group, and could be served as a useful tool for individual identifications in Hui group. Population genetic evaluations indicated that Chinese Hui group had close genetic relationships with East Asian populations.

12.
Front Physiol ; 10: 1038, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31474876

RESUMO

Extracellular signal-regulated kinase 1/2 (ERK1/2), an important member of the mitogen-activated protein kinase family, is found in many organisms, and it participates in intracellular signal transduction. Various stimuli induce phosphorylation of ERK1/2 in vivo and in vitro. Phosphorylated ERK1/2 moves to the nucleus, activates many transcription factors, regulates gene expression, and controls various physiological processes, finally inducing repair processes or cell death. With the aging of the population around the world, the occurrence of ischemia-reperfusion injury (IRI), especially in the brain, heart, kidney, and other important organs, is becoming increasingly serious. Abnormal activation of the ERK1/2 signaling pathway is closely related to the development and the metabolic mechanisms of IRI. However, the effects of this signaling pathway and the underlying mechanism differ between various models of IRI. This review summarizes the ERK1/2 signaling pathway and the molecular mechanism underlying its role in models of IRI in the brain, heart, liver, kidneys, and other organs. This information will help to deepen the understanding of ERK1/2 signals and deepen the exploration of IRI treatment based on the ERK1/2 study.

13.
Sci Rep ; 9(1): 9818, 2019 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-31285493

RESUMO

The combustible gas produced by coal pyrolysis can be used as a clean fuel to reduce environmental pollution caused by coal combustion. In order to improve the efficiency of coal pyrolysis to prepare flammable gases, Ni-Co supported pyrolysis catalysts were prepared by equal volume impregnation method using the pyrolysis coke of different pyrolysis final temperatures as the carrier in this study. The effects of different pyrolysis final temperatures and different metal loadings on pyrolysis products were studied. The cracking mechanism of the catalysts was characterized by BET, XRD, XPS and SEM. The results show that: (1) the catalytic efficiency of pyrolysis coke catalyst is mainly related to the metal type and loading of the additive. (2) The optimum preparation conditions for the supported catalyst are: use pyrolysis coke with 750 °C final pyrolysis temperature as the carrier, the loading amount of Ni is 5%, and the loading amount of Co is 8%.

14.
Cell Signal ; 62: 109348, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31233841

RESUMO

The neuropeptide orexin-A (OXA) has a neuroprotective effect, acting as an anti-apoptotic factor in response to multiple stimuli. Apoptosis induced by endoplasmic reticulum stress (ERS) underlies oxygen-glucose deprivation and reoxygenation (OGD/R)-induced cell damage, an in vitro model of ischemia/reperfusion injury. However, that OXA inhibits ERS-induced apoptosis in the OGD/R model has not been reported. In the present study, we investigated the neuroprotective effect of OXA (0.1 µM) on OGD/R-induced damage in the human neuroblastoma cell line SH-SY5Y. After OXA treatment following 4 h oxygen-glucose deprivation (OGD) and then 4 h reoxygenation (R), cell morphology, viability, and apoptosis were analyzed by histology, Cell Counting Kit-8 assay, and flow cytometry, respectively. Western blotting was used to measure expression levels of ERS- and apoptosis-related proteins. To determine signaling pathways involved in OXA-mediated neuroprotection, the Gi pathway inhibitor pertussis toxin (PTX; 100 ng/mL) and PI3K inhibitor LY294002 (LY; 10 µM) were added. In addition, in order to prove the specificity of these characteristics, the OXA antagonist Suvorexant (DORA; Ki of 0.55 nM and 0.35 nM for OX1R and OX2R) was used for intervention. Our results showed that OGD/R induced cell damage, manifested as morphological changes and a significant decrease in viability. Furthermore, Western blotting detected an increase in ERS-related proteins GRP78, p-IRE1α, p-JNK, and Cleaved caspase-12, as well as apoptosis-related proteins Cleaved caspase-3 and Bax, and a decrease in the anti-apoptosis factor Bcl-2. OXA intervention alleviated the degree of cellular damage, and protein expression was also reversed. In addition, the protective effect of OXA was reduced by adding PTX and LY. Meanwhile, after the use of DORA, changes in the expression of related proteins were detected, and it was found that the protective effect of OXA was weakened. Collectively, our results indicate that OXA has a neuroprotective effect on OGD/R-induced cell damage by inhibiting ERS-induced apoptosis through the combined action of Gi and PI3K signaling pathways. These findings help to clarify the mechanism underlying the neuroprotective action of OXA, which should aid the development of further candidate drugs, and provide a new therapeutic direction for the treatment of ischemic stroke.

15.
PeerJ ; 7: e6802, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31086740

RESUMO

On the purpose of enhancing the forensic efficiency of CODIS STR loci, new STR loci have been gradually discovered and developed into some commercial multiplex systems. Recently, 22 STR loci including 18 non-CODIS STR loci and four CODIS STR loci were investigated in 501 unrelated healthy individuals of Kazakh ethnic group. Seven to 20 alleles at the different loci were identified and altogether 276 alleles for 22 selected loci were detected with the corresponding allelic frequencies ranging from 0.0010 to 0.3623. No significant deviation was observed from the Hardy-Weinberg equilibrium test for any of the 22 STRs. The value of cumulative power of discrimination in Kazakh group was 1-1.00E-28. Analyses of population differentiations and genetic distances between Kazakh and other Chinese groups presented that the Kazakh group with the Uygur group. These 22 STR loci evenly distributed on 22 different autosomal chromosomes were characterized by high genetic diversities and therefore could be utilized in the forensic cases to further increase the discrimination performance.

16.
Cell Prolif ; 52(3): e12586, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30997713

RESUMO

OBJECTIVES: This study aimed at investigating cellular uptake pathways of carbon dots (CDs) in human adenoid cystic carcinoma cell line ACC-2. MATERIALS AND METHODS: We synthesized CDs using a hydrothermal method with citric acid and polyethylenimine (PEI, Mw = 25 000). The CDs incubated with the ACC-2 cells showed their bioimaging capabilities using a confocal microscopy test. Flow cytometry was used to analyse cellular uptake pathways of CDs in ACC-2 cells. RESULTS: Our findings indicated that CDs possessed good biocompatibility in ACC-2 cells. CDs were endocytosed mainly via micropinocytosis and energy-dependent pathways. CONCLUSIONS: In general, these findings suggested that CDs had excellent biomedical imaging properties for ACC-2 cells and there was a potential opportunity to develop biomedical applications.


Assuntos
Carbono , Carcinoma Adenoide Cístico/fisiopatologia , Endocitose , Nanopartículas , Neoplasias das Glândulas Salivares/fisiopatologia , Transporte Biológico Ativo , Carcinoma Adenoide Cístico/diagnóstico por imagem , Linhagem Celular Tumoral , Humanos , Cinética , Microscopia Confocal , Neoplasias das Glândulas Salivares/diagnóstico por imagem
17.
Sci Rep ; 9(1): 5659, 2019 Apr 04.
Artigo em Inglês | MEDLINE | ID: mdl-30948734

RESUMO

A series of Ti/Li/Al ternary layered double hydroxides (TiLiAl-LDHs) with different Ti:Li:Al molar ratios were prepared by a coprecipitation method for photocatalytic CO2 reduction. It was demonstrated that the contents of anions between the layers of Ti/Li/Al-LDHs greatly determined the photocatalytic activity for CO2 reduction. With Ti:Li:Al molar ratios optimized to be 1:3:2, the largest contents of [Formula: see text]- anion and hydroxyl group were obtained for the Ti1Li3Al2-LDHs sample, which exhibited the highest photocatalytic activity for CO2 reduction, with CH4 production rate achieving 1.33 mmol h-1 g-1. Moreover, the theoretical calculations show that Ti1Li3Al2-LDHs is a p-type semiconductor with the narrowest band gap among all the obtained TiLiAl-LDHs. After calcined at high temperatures such as 700 °C, and the obtained TiLiAl-700 sample showed much increased photocatalytic activity for CO2 reduction, with CH4 production rate reaching about 1.59 mmol h-1 g-1. This calcination induced photocatalytic enhancement should be related to the cystal structure transformation from hydrotalcite to mixed oxides containing high reactive oxygen species for more efficient CO2 reduction.

18.
Small ; 15(32): e1900772, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30977981

RESUMO

Artificial photosynthesis for solar water splitting and CO2 reduction to produce hydrogen and hydrocarbon fuels has been considered as one of the most promising ways to solve increasingly serious energy and environmental problems. As a well-documented metal-free semiconductor, polymeric carbon nitride (PCN) has been widely used and intensively investigated for photocatalytic water splitting and CO2 reduction, owing to its physicochemical stability, visible-light response, and facile synthesis. However, PCN as a photocatalyst still suffers from the fast recombination of electron-hole pairs and poor water redox reaction kinetics, greatly restricting its activity for artificial photosynthesis. Among the various modification approaches developed so far, decorating PCN with metals in different existences of nanoparticles, single atoms and molecular complexes, has been evidently very effective to overcome these limitations to improve photocatalytic performances. In this Review article, a systematic introduction to the state-of-the-art metal/PCN photocatalyst systems is given, with metals in versatility of nanoparticles, single atoms, and molecular complexes. Then, the recent processes of the metal/PCN photocatalyst systems in the applications of artificial photosynthesis, e.g., water splitting and CO2 reduction, are reviewed. Finally, the remaining challenges and opportunities for the development of high efficiency metal/PCN photocatalyst systems are presented and prospected.

19.
J Zhejiang Univ Sci B ; 20(3): 287-290, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30829016

RESUMO

To further enrich the genetic data of the Chinese Xinjiang Mongolian group, the genetic distribution and forensic parameters of 19 autosomal short tandem repeats (STRs) were investigated. Altogether, 249 alleles were observed in these 19 STRs. The mean values of the polymorphism information content (PIC), match probability (MP), discrimination power (DP), and probability of exclusion (PE) for these 19 STRs were 0.7775, 0.0699, 0.9301, and 0.6085, respectively. Additionally, the cumulative DP and PE values obtained in the Mongolian group were 0.999 999 999 999 999 999 999 995 67 and 0.999 999 992 163, respectively. Furthermore, population genetic analysis of the Mongolian group and 20 published populations was conducted based on the population data of 15 overlapping STRs. Genetic distances indicated that the Mongolian group had closer genetic similarities with the Uyghur, Xibe, and other Chinese populations rather than the other continental populations. Multidimensional scaling analysis further revealed that the Mongolian group possessed similar genetic distributions as most Chinese populations. To sum it all up, these STRs could be used as an extremely efficient tool for forensic applications in the Xinjiang Mongolian group.


Assuntos
Grupo com Ancestrais do Continente Asiático/genética , Marcadores Genéticos , Repetições de Microssatélites , Alelos , China , Impressões Digitais de DNA , Bases de Dados Genéticas , Grupos Étnicos/genética , Frequência do Gene , Genética Populacional , Genoma Humano , Humanos , Desequilíbrio de Ligação , Mongólia , Polimorfismo Genético , Análise de Componente Principal , Probabilidade , Software
20.
Oncol Lett ; 17(3): 3355-3361, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30867770

RESUMO

The present study aimed to examine whether serum microRNA (miR)-22 may be considered a potential biomarker to differentiate patients with papillary thyroid cancer (PTC) from healthy controls. Reverse transcription-quantitative polymerase chain reaction demonstrated that serum miR-22 expression was significantly enhanced in patients with PTC compared with in patients with benign thyroid nodules (BTN) and healthy controls. The expression levels of miR-22 were also increased in the thyroid tissue of patients with PTC compared with in patients with BTN. In addition, increased miR-22 in the serum of patients with PTC was positively associated with metastasis. Furthermore, miR-22 serum levels were increased in patients with PTC and the B-Raf proto-oncogene, serine/threonine kinase V600E mutation. Meanwhile, compared with patients with PTC and ≤1 ng/ml thyroglobulin (Tg)-fine needle aspiration biopsy (FNAB), serum miR-22 was significantly enhanced in patients with PTC and 1-10 ng/ml Tg-FNAB and >10 ng/ml Tg-FNAB. A receiver operating characteristic analysis demonstrated that serum miR-22 distinguished patients with PTC from patients with BTN and healthy controls. In conclusion, to the best of our knowledge, the present study was the first to demonstrate that upregulation of serum miR-22 may be used as a potential biomarker to distinguish patients with PTC from healthy controls.

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