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1.
Invest Ophthalmol Vis Sci ; 62(12): 21, 2021 09 02.
Artigo em Inglês | MEDLINE | ID: mdl-34546323

RESUMO

Purpose: To identify the impact of hypertension (HTN) on macular microvasculature in type 2 diabetes (T2DM) patients without clinical diabetic retinopathy. Methods: In this retrospective cross-sectional study, subjects were divided into three groups: controls (control group), patients with T2DM (DM group), and patients with both T2DM and HTN (DM + HTN group). The vessel length density (VD) was compared among the groups. Linear regression analyses were performed to identify factors associated with VD. Results: The VD in the control, DM, and DM + HTN groups was 20.43 ± 1.16, 19.50 ± 1.45, and 18.19 ± 2.06 mm-1, respectively (P < 0.001). The best-corrected visual acuity (B = -9.30; P = 0.002), duration of T2DM (B = -0.04; P = 0.020), HTN (B = -0.51; P = 0.016), signal strength (B = 1.12; P < 0.001), and ganglion cell-inner plexiform layer thickness (B = 0.06; P < 0.001) were significant factors affecting VD in patients with T2DM. Additionally, the hemoglobin A1c (HbA1c) (B = -0.49; P = 0.016) was significantly associated with VD in patients with both T2DM and HTN. Conclusions: Patients with T2DM had impaired macular microvasculature, and patients with T2DM with HTN exhibited greater impairment of the microvasculature than did patients with T2DM only. Additionally, physicians should be aware that the macular microvasculature would be more vulnerable to hyperglycemic damage under ischemic conditions by HTN.


Assuntos
Diabetes Mellitus Tipo 2/fisiopatologia , Retinopatia Diabética/fisiopatologia , Hipertensão/fisiopatologia , Disco Óptico/irrigação sanguínea , Vasos Retinianos/fisiopatologia , Idoso , Pressão Sanguínea/fisiologia , Estudos Transversais , Feminino , Angiofluoresceinografia , Hemoglobina A Glicada/metabolismo , Humanos , Masculino , Microvasos/fisiopatologia , Pessoa de Meia-Idade , Células Ganglionares da Retina/patologia , Estudos Retrospectivos , Tomografia de Coerência Óptica , Acuidade Visual/fisiologia
2.
PLoS One ; 16(8): e0256131, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34388218

RESUMO

PURPOSE: To identify the impacts of hypertension (HTN), high myopia, and the combination thereof on peripapillary retinal nerve fiber layer (pRNFL) thickness. METHODS: All subjects were divided into four groups: control (group 1); patients with HTN without high myopia (group 2); patients with high myopia without HTN (group 3); and patients with both HTN and high myopia (group 4). The pRNFL thicknesses were compared using a one-way analysis of variance. Univariate and multivariate linear regression analyses were used to identify factors affecting pRNFL thickness in subjects with and without HTN. RESULTS: The mean pRNFL thicknesses were 93.9±8.8, 88.7±6.8, 86.4±8.1, and 82.5±9.6 µm in group 1, 2, 3, and 4, respectively, and differed significantly (P<0.001). On multivariate linear regression analyses, age (ß = -0.181, P = 0.044), axial length (ß = -1.491, P<0.001), and HTN (ß = -4.876, P = 0.044) significantly affected pRNFL thickness. Additionally, age and axial length affected the pRNFL thickness in subjects with HTN (age, ß = -0.254, P = 0.020; axial length, ß = -1.608, P<0.001) much more than in subjects without HTN (age, ß = -0.028, P = 0.712; axial length, ß = -1.324, P<0.001). CONCLUSIONS: High myopia and HTN affected pRNFL reduction and a combination of the 2 diseases exacerbated pRNFL damage. This could be a confounding factor in interpreting pRNFL thickness in patients with ophthalmic diseases affecting the pRNFL thickness when combined with the 2 diseases.


Assuntos
Hipertensão/fisiopatologia , Pressão Intraocular/fisiologia , Miopia/epidemiologia , Fibras Nervosas/patologia , Retina/patologia , Acuidade Visual/fisiologia , Estudos de Casos e Controles , Comorbidade , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Miopia/patologia , República da Coreia/epidemiologia , Estudos Retrospectivos , Tomografia de Coerência Óptica/métodos
3.
PLoS One ; 15(6): e0234933, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32584907

RESUMO

PURPOSE: To determine the repeatability of superficial vessel density measurements using Spectral domain Ocular coherence tomography angiography(SD-OCTA) in patients diagnosed with retinal vein occlusion(RVO). DESIGN: Prospective observational study. SUBJECTS: Patients who visited our retinal clinic from August 2017 to August 2018, diagnosed with RVO were recruited for the study. METHODS: Two consecutive 3×3 mm pattern scans were performed using the Cirrus HD-OCT 5000 along with AngioPlex software (Carl Zeiss Meditec) in each eye by single skilled examiner. All scans were analyzed using en face OCTA images to measure vessel density (VD) automatically. For further analysis of the effect of central macular thickness(CMT), eyes were divided into two groups according to CMT of 400µm (Group 1: CMT > 400µm, Group 2: CMT < 400µm). To identify factors affecting the repeatability of VD measurements, linear regression analyses were conducted for the coefficient of variation (CV) of VD by investigating demographics and ocular variables. MAIN OUTCOME MEASURES: The intraclass correlation coefficient (ICC), coefficient of variation (CV) of VD measurements. RESULTS: A total of 57 eyes from 57 patients were examined: 35 eyes with BRVO and 22 eyes with CRVO. In all 57 eyes with RVO, the ICC and CV of the full VD(VD of 3mm diameter circle) were 0.800 and 10.61%, respectively. Univariate analyses showed that the mean CMT (B, 0.001; p<0.001) and mean ganglion cell-Inner plexiform layer (GC-IPL) thickness (B, -0.002; p = 0.020) were significant factors that affected the repeatability. Multivariate analyses of these two factors showed that only mean CMT was a significant factor. The ICC and CV of the full VD in group 1 (CMT > 400µm) were 0.348 and 22.55% respectively. In group 2 (CMT < 400µm), the ICC and CV of the full VD were 0.910 and 7.76%, respectively. CONCLUSIONS: The repeatability of VD measurement in eyes with RVO was reasonably comparable to previous studies. Repeatability of VD measurement was significantly affected by central macular thickness.


Assuntos
Angiografia por Tomografia Computadorizada/métodos , Oclusão da Veia Retiniana/diagnóstico , Vasos Retinianos/diagnóstico por imagem , Tomografia de Coerência Óptica/métodos , Idoso , Feminino , Angiofluoresceinografia , Fóvea Central/irrigação sanguínea , Fóvea Central/diagnóstico por imagem , Fundo de Olho , Humanos , Masculino , Memória Episódica , Pessoa de Meia-Idade , Estudos Prospectivos , Reprodutibilidade dos Testes
4.
Acta Ophthalmol ; 98(1): e36-e42, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31509329

RESUMO

PURPOSE: To determine the long-term repeatability of optical coherence tomography angiography (OCTA) parameters in normal eyes. METHODS: We prospectively enrolled 104 normal eyes. Participants were divided into three groups based on differences in the signal strength (SS) of OCTA scans obtained at two visits at least 6 months apart: group 1, SS difference = 2; group 2, 1; group 3, 0. We measured a foveal centred scan area of 3 × 3 mm pattern. All measurements were performed twice at 5-min intervals at the initial visit. The second measurements were performed at least 6 months later. RESULTS: In short-term vessel density (VD) repeatability, the coefficient of variation (CV) ranged from 3.89% to 8.10% and the intraclass correlation coefficient (ICC) ranged from 0.785 to 0.941. In terms of long-term repeatability, the CV was 5.39-12.62% and the ICC was 0.598-0.867. In group 1, the ICCs of the inner and full VDs were 0.194 and 0.221, respectively. In groups 2 and 3, the ICCs of the inner and full VDs were 0.611 and 0.603, and 0.763 and 0.765, respectively. The central VDs of all groups had high CV besides high ICC. CONCLUSIONS: Optical coherence tomography angiography parameters showed good short-term and reasonable long-term repeatability in normal individuals. The differences in SSs between measurements affected such repeatability, so physicians should query the reliability of OCTA parameters when the differences in SS are 2 or more even when the SS is high.


Assuntos
Angiofluoresceinografia/métodos , Fóvea Central/diagnóstico por imagem , Disco Óptico/diagnóstico por imagem , Vasos Retinianos/diagnóstico por imagem , Tomografia de Coerência Óptica/métodos , Estudos Transversais , Feminino , Seguimentos , Fundo de Olho , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Reprodutibilidade dos Testes , Fatores de Tempo
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