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Artigo em Inglês | MEDLINE | ID: mdl-31771941


Tightly regulated immune responses must occur in the intestine in order to avoid unwanted inflammation, which may cause chronic sequela and leading to diseases such as colorectal cancer. Toll-like receptors play an important role in preventing aberrant immune responses in the intestine by sensing endogenous commensal microbiota and delivering important regulatory signals to the tissue. However, the role that specific innate receptors may play in the development of chronic inflammation and their impact on the composition of the colonic microbiota is not well understood. Using a model of inflammation induced colorectal cancer, we found that Lactobacillus species are lost more quickly in wild type mice than TLR6-deficient mice resulting in overall differences in bacterial composition. Despite the longer retention of Lactobacillus, the TLR6-deficient mice presented with more tumors and a worse overall outcome. Restoration of the lost Lactobacillus species suppressed inflammation, reduced tumor number and prevented change in the abundance of Proteobacteria only when given to WT mice, indicating the effect of these Lactobacillus are TLR6-dependent. We found that the TLR6-dependent effects of Lactobacillus could be dissociated from one another via the involvement of IL-10, which was necessary to dampen the inflammatory microenvironment, but had no effect on bacterial composition. Altogether, these data suggest that innate immune signals can shape the composition of the microbiota under chronic inflammatory conditions, bias the cytokine milieu of the tissue microenvironment, and influence the response to microbiota-associated therapies.

Cell Host Microbe ; 26(4): 446-448, 2019 10 09.
Artigo em Inglês | MEDLINE | ID: mdl-31600496


The diet-microbiome interaction can positively or negatively affect our health depending on dietary habits. In this issue of Cell Host & Microbe, Wolf et al. (2019) highlight the beneficial roles of gut commensal Collinsella in degrading potentially toxic food contaminants, called Maillard reaction products, found in processed foods.

Microbioma Gastrointestinal , Bactérias , Biodegradação Ambiental , Dieta , Manipulação de Alimentos , Humanos
J Infect Public Health ; 8(4): 309-13, 2015 Jul-Aug.
Artigo em Inglês | MEDLINE | ID: mdl-25747822


This paper describes a case of lung injury attributed to the use of Nitrofurantoin and a review of the relevant literature. An 88-year-old woman was admitted to the floor for the evaluation of recent symptoms of dyspnea, fatigue and productive cough. She was initiated on nitrofurantoin 300 mg per day for the treatment of a urinary tract infection 3 days earlier. Upon examination, chest auscultation revealed bilateral inspiratory crackles. Chest radiograph showed bilateral airspace and interstitial infiltrates. Laboratory studies revealed an elevated white blood cell count of 13,500/µL (reference range = 5200-12,400/µL) and blood eosinophilia (10%, reference range: 0-7%). Using clinical judgment and the algorithm of Naranjo, it was determined that nitrofurantoin use was the probable cause of the patient's lung injury. Symptomatic improvement was observed shortly after the drug was discontinued. A review of information from several European and North American pharmacovigilance databases (through June 2014) identified several reports of suspected nitrofurantoin-induced toxicity, including reports of acute toxicity reactions, which were related in many ways to the case we are reporting here.

Lesão Pulmonar Aguda/induzido quimicamente , Anti-Infecciosos Urinários/toxicidade , Nitrofurantoína/toxicidade , Lesão Pulmonar Aguda/diagnóstico , Idoso de 80 Anos ou mais , Feminino , Humanos , Infecções Urinárias/tratamento farmacológico