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1.
Adv Gerontol ; 34(3): 375-383, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34409816

RESUMO

Continuous improvement of protocols for the treatment of various ailments, in particular, osteochondrosis, is one of the important tasks of providing medical care to elderly patients. Supplementation of treatment with Cytoflavin and biofeed-back therapy seems to be a promising solution, however, it is necessary to develop an algorithm to predict it effectiveness in patients taking into account their initial clinical and psychophysiological status. As a result of the treatment, predictors of the effectiveness of the use of Cytoflavin and biofeed-back therapy have been identified and an algorithm for their administration has been developed.


Assuntos
Inosina Difosfato , Osteocondrose , Idoso , Algoritmos , Combinação de Medicamentos , Mononucleotídeo de Flavina , Humanos , Niacinamida , Succinatos , Resultado do Tratamento
2.
Adv Gerontol ; 34(2): 306-310, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34245516

RESUMO

One of the ways to improve the condition of the elderly body is the method of auto-training with biofeedback, as a means of correcting deviations in the functioning of the regulatory apparatus, as well as improving antioxidant protection and eliminating the effects of oxidative stress using Cytoflavin therapy. These methods seem to be a simple and effective means of correcting negative changes in the FS of elderly hockey players after a training cycle and ensuring the possibility of a more complete recovery of their body. The difference in the points of application made it possible to combine the intake of Cytoflavin and biofeedback training into a single complex correctional and restorative technique. Purpose of the research: to consider the organizational and methodological aspects of introducing a comprehensive methodology for correcting the functional state of elderly hockey players into the system of support of their training process. Based on the results of the study, we have obtained convincing data on the positive effect of the inclusion of Cytoflavin and biofeedback training in the system of medical support for the training process of elderly hockey players. The organizational and methodological aspects of introducing a comprehensive methodology for correcting the functional state of older hockey players into the system of support for their training process considered in this article make it possible to solve a number of problems facing medical workers regarding continuous monitoring of the functional state of older hockey players, proactive diagnosis of their negative deviations, as well as a system of reabilitation.


Assuntos
Hóquei , Idoso , Antioxidantes , Combinação de Medicamentos , Mononucleotídeo de Flavina , Humanos , Inosina Difosfato , Niacinamida , Succinatos
3.
Khirurgiia (Mosk) ; (3): 42-49, 2021.
Artigo em Russo | MEDLINE | ID: mdl-33710825

RESUMO

OBJECTIVE: To evaluate the early outcomes of simultaneous surgeries in patients with concomitant lung cancer and coronary artery disease. MATERIAL AND METHODS: We retrospectively reviewed 37 consecutive patients who underwent CABG with adjunct endarterectomy (n=21) or long segmental coronary artery reconstruction (n=25) and lung resection between 2003 and 2019. Mean age was 61.4±6.7 (range 58-71) years. Males prevailed (n=32, 86.4%). Median sternotomy was used in all patients. Myocardial revascularization was followed by on-pump lung resection. The most common procedure was lobectomy (94.6%) of the right upper lobe (83.7%). Lymph node dissection was performed in all patients. RESULTS: CPB time was 162±19.3 min, aortic cross-clamping time 71±14.2 min. There was no in-hospital mortality. Incidence of perioperative myocardial infarction was 5.4%. Postoperative complications were atrial fibrillation (n=6, 16.6%), re-exploration for bleeding (n=1, 2.7%), pneumonia (n=2, 5.4%). Mean hospital-stay was 14.4 days (range 11-21). CONCLUSION: Simultaneous lung resections and coronary artery reconstruction is a safe and reliable surgical method in patients with diffuse coronary atherosclerosis and lung cancer. The developed system of choice, evaluation and surgical treatment of patients with concomitant cardiopulmonary pathology is fundamental for successful treatment of these difficult patients. We need larger randomized studies for certainty.


Assuntos
Ponte de Artéria Coronária , Doença da Artéria Coronariana , Neoplasias Pulmonares , Pneumonectomia , Idoso , Ponte de Artéria Coronária/métodos , Doença da Artéria Coronariana/complicações , Doença da Artéria Coronariana/diagnóstico , Doença da Artéria Coronariana/cirurgia , Endarterectomia , Feminino , Humanos , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/cirurgia , Excisão de Linfonodo , Masculino , Pessoa de Meia-Idade , Pneumonectomia/métodos , Estudos Retrospectivos , Esternotomia , Resultado do Tratamento
4.
Artigo em Russo | MEDLINE | ID: mdl-33244954

RESUMO

OBJECTIVE: To assess an effect of cytoflavin on the results of rehabilitation treatment and the increase in exercise tolerance in patients with stroke complicated by post-intensive care syndrome (PICS). MATERIAL AND METHODS: The data of 53 patients who underwent neurorehabilitation in the ICU after ischemic stroke were analyzed. Depending on the treatment regimen, the patients were divided into two groups. Group 1 (main, n=36) received cytoflavin (iv drip in a volume of 10 ml of a solution for injections per 200 ml of a 0.9% solution of sodium chloride) for 10 days in addition to the complex of neurorehabilitation measures. Group 2 (control, n=17) included patients, who had only a standard set of neurorehabilitation measures for 10 days. The efficacy of the therapy was evaluated using indirect calorimetry, and the oxygen and energy load price index was calculated. To assess the tolerability of rehabilitation methods, a verticalization test was used. Treatment tolerance was assessed by the incidence of adverse reactions in each group. RESULTS AND CONCLUSION: The components of the energytropic effect of cytoflavin can have a positive modulating effect, increasing the tolerance of rehabilitation measures for the treatment of PICS in patients with ischemic stroke. Further research is required.


Assuntos
Isquemia Encefálica , Reabilitação do Acidente Vascular Cerebral , Acidente Vascular Cerebral , Isquemia Encefálica/complicações , Isquemia Encefálica/tratamento farmacológico , Cuidados Críticos , Combinação de Medicamentos , Mononucleotídeo de Flavina/uso terapêutico , Humanos , Inosina Difosfato , Niacinamida , Acidente Vascular Cerebral/complicações , Acidente Vascular Cerebral/tratamento farmacológico , Succinatos/uso terapêutico , Resultado do Tratamento
5.
Khirurgiia (Mosk) ; (10): 11-22, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33047581

RESUMO

OBJECTIVE: To summarize our experience in transsternal occlusion of main bronchus fistula. MATERIAL AND METHODS: We have performed 146 transsternal occlusions of the main bronchi for the period from 1979 to 2018. There were 123 (84.2%) men and 23 (15.7%) women. Mean age of patients was 63 years. Lung tuberculosis was diagnosed in 36 (24.7%) patients, lung cancer - 91 (62.3%) patients, non-specific suppurative lung diseases - 14 (9.6%) patients, trauma - 5 (3.4%) patients. All patients underwent transsternal occlusion of the main bronchi fistulae with or without pericardial cavity dissection. Wedge-shaped bronchial resection or tracheal bifurcation resection were carried out for a short stump fistula. RESULTS: Perioperative complications occurred in 28 (19.2%) out of 146 patients. Intraoperative complications developed in 4 (2.6%) patients. Postoperative complications were observed in 25 (17.1%) patients. Intraoperative mortality rate was 1.4% (n=2), postoperative mortality - 6.2% (n=9). Thus, overall mortality rate was 7.6% (n=11 It should be noted that intraoperative complications were absent if dissection of the pericardium and pulmonary artery stump ligation were not performed. CONCLUSION: Transsternal occlusion of the main bronchi fistulae was successful in 80.8% of patients. In these cases, healing of fistulae was not associated with any complications. Thus, we believe that transsternal occlusion of the main bronchial stump fistula should be considered as preferable surgical strategy.


Assuntos
Brônquios/cirurgia , Fístula Brônquica/cirurgia , Pneumopatias/cirurgia , Pneumonectomia/efeitos adversos , Procedimentos Cirúrgicos Torácicos/métodos , Brônquios/lesões , Fístula Brônquica/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Esterno/cirurgia , Procedimentos Cirúrgicos Torácicos/efeitos adversos
6.
Khirurgiia (Mosk) ; (10): 69-72, 2018.
Artigo em Russo | MEDLINE | ID: mdl-30531740

RESUMO

The aim of this study was to evaluate the effect of cytoflavin inclusion in therapy regimens of patients with diabetic foot syndrome and medicalcinosis on the microcirculation of the lower limb blood vessels. For this purpose, 64 patients with type II diabetes mellitus (subcompensated form), diabetic foot syndrome and signs of medicalcinosis foot blood vessels of various severity were examined. All patients were divided into 2 groups depending on the therapy scheme: patients of group I (33 people) received insulin, antibiotics, disaggregants, statins, anti-inflammatory drugs, painkillers, detoxification therapy. Patients of group II (31 patients) in addition to the main therapy received cytoflavin according to the scheme: 10 ml per 0.9 ml NaCl 200 ml intravenously, drip at a rate of 60 cap/min, 10 days course, then 2 tablets 2 times a day for 1 month. The severity of the microangiopathy of the lower extremities was assessed considering transcutaneous oximetry data in dynamics (before treatment, on the 10th and 40th day of therapy) gained using TCM-2 device (RADIOMETER, Denmark) with has heating oxygen electrode type Clarc. Before the treatment subcompensated level of metabolic disorders corresponding to the II degree of microcirculatory disorders was registered in all patients. Against the backdrop of cytoflavin inclusion in the complex therapy, there was an improvement in the metabolic rate (up to compensated) with a decrease in the degree of microcirculation disorders up to I degree. Positive dynamics of metabolic disorders significantly reduced frequency and extent of surgical interventions. The results obtained suggest that cytoflavin should be included in the treatment regimens of patients with this pathology.


Assuntos
Diabetes Mellitus Tipo 2 , Pé Diabético , Humanos , Extremidade Inferior , Microcirculação
7.
Adv Gerontol ; 31(2): 239-245, 2018.
Artigo em Russo | MEDLINE | ID: mdl-30080331

RESUMO

In this article materials obtained during treatment of 61 patients with acute poisoning with phenobarbital, which is part of Corvalol and Valocordin, are presented. It has already been established that phenobarbital acute poisoning in elderly and senile patients is accompanied by more frequent development of central nervous system, respiratory system (pneumonia) and cardiovascular system complications, which cause more severe clinical course and risk of an adverse outcome of acute poisoning. This research has shown that for hypoxia correction during phenobarbital acute poisoning in elderly and senile patients it is advisable to include Reamberin in the treatment regimen, which has no adverse effects on central haemodynamic parameters and effectively reduces severity of metabolic disorders.


Assuntos
Barbitúricos/envenenamento , Hipóxia/terapia , Idoso , Humanos , Hipóxia/induzido quimicamente , Intoxicação/terapia
8.
Ter Arkh ; 89(11): 84-92, 2017.
Artigo em Russo | MEDLINE | ID: mdl-29260751

RESUMO

The authors carried out a systematic review and subsequent meta-analysis of randomized clinical trials evaluating the efficacy of the immunomodulator agent cycloferon as tablets in adults and children with viral respiratory diseases. A total estimate of its clinical efficacy was obtained in terms of compared heterogeneous groups and response variables. The data published in 16 articles were used to calculate the formal parameters of the clinical efficacy of cycloferon (increased absolute and relative benefits, odds ratio (OR); the number of patients needed to be additionally treated with cycloferon to achieve a favorable outcome or to prevent a poor outcome in one patient, etc.). High heterogeneity hampered the unequivocal interpretation of results; however, combining the compared homogeneous groups in the meta-analysis (with adjustments for fixed and random effects) increased the statistical power of the investigation. In children aged 6 to 18 years, the OR for the positive effect of the drug (no new cases after its preventive administration) was 5.3 (95% confidence interval (CI), 4.8-5.9), heterogeneity test, χ2 = 249.5; p=0.000...; I2 = 94.8% (95% CI, 92.7-96.3%). This suggested the heterogeneity of clinical trial data and extrapolated this estimate to medical practice. The use of cycloferon in adults to treat acute respiratory viral infection enhanced their chances of enduring the disease in a mild form and avoiding serious complications: the OR for positive outcomes was 9.7 (95% CI, 7.0-13.0), while the effect was more homogeneous than in children (heterogeneity test, χ2 = 7.4; p=0.061...; I2 = 59.4% (95% CI, 0-86.5). Thus, the use of cycloferon to treat and prevent acute viral respiratory infections showed a more than 5-fold increase in the probability of avoiding the disease or enduring the latter in a mild form.


Assuntos
Acridinas/farmacologia , Imunomodulação , Indutores de Interferon/farmacologia , Infecções Respiratórias/tratamento farmacológico , Viroses/tratamento farmacológico , Acridinas/administração & dosagem , Humanos , Indutores de Interferon/administração & dosagem
9.
Adv Gerontol ; 30(4): 601-608, 2017.
Artigo em Russo | MEDLINE | ID: mdl-28968038

RESUMO

We conducted a study of 150 patients on the basis of polyclinic № 91 in St. Petersburg. The effect of Cytoflavin and bio-inverse communication therapy on the dynamics of the condition of elderly patients with osteochondrosis was evaluated. A number of positive effects from such an addition to existing therapy, potentiating the nominal effect, were revealed.


Assuntos
Comunicação , Mononucleotídeo de Flavina/farmacologia , Inosina Difosfato/farmacologia , Niacinamida/farmacologia , Osteocondrose/tratamento farmacológico , Succinatos/farmacologia , Idoso , Combinação de Medicamentos , Humanos , Osteocondrose/fisiopatologia , Osteocondrose/psicologia , Resultado do Tratamento
10.
Khirurgiia (Mosk) ; (8): 75-78, 2017.
Artigo em Russo | MEDLINE | ID: mdl-28805783

RESUMO

The aim of the study was to evaluate the effectiveness of cytoflavin in the complex treatment of patients with diabetic foot syndrome. MATERIAL AND METHODS: The research is based on the results of a comprehensive survey of 140 people with diabetic foot syndrome. Depending on the treatment, all patients were divided into 2 groups. The first group (n=35) received basic therapy. The second group (n=35) in addition to basic therapy received cytoflavin 10 ml (+200 ml 0.9% NaCl) for 10 days, followed by switching to the tablet form of the drug 2 tablets twice a day for 1 month. RESULTS: Analyzing the severity of polyneuropathy after treatment, we noted a more positive dynamic in patients who in addition to standard therapy received cytoflavin.


Assuntos
Pé Diabético , Mononucleotídeo de Flavina , Inosina Difosfato , Niacinamida , Polineuropatias , Succinatos , Calcificação Vascular , Idoso , Artérias/diagnóstico por imagem , Artérias/patologia , Pé Diabético/complicações , Pé Diabético/diagnóstico , Pé Diabético/terapia , Combinação de Medicamentos , Feminino , Mononucleotídeo de Flavina/administração & dosagem , Mononucleotídeo de Flavina/efeitos adversos , Humanos , Inosina Difosfato/administração & dosagem , Inosina Difosfato/efeitos adversos , Masculino , Pessoa de Meia-Idade , Fármacos Neuroprotetores/administração & dosagem , Fármacos Neuroprotetores/efeitos adversos , Niacinamida/administração & dosagem , Niacinamida/efeitos adversos , Polineuropatias/complicações , Polineuropatias/diagnóstico , Índice de Gravidade de Doença , Succinatos/administração & dosagem , Succinatos/efeitos adversos , Resultado do Tratamento , Ucrânia , Calcificação Vascular/complicações , Calcificação Vascular/diagnóstico
11.
Khirurgiia (Mosk) ; (6): 55-59, 2017.
Artigo em Russo | MEDLINE | ID: mdl-28638015

RESUMO

AIM: To improve the results of treatment of patients with acute small bowel obstruction. MATERIAL AND METHODS: The research is based on the results of a comprehensive survey 202 people with acute small bowel obstruction. Reamberin was used in 102 patients treatment. RESULTS: It was established that metalloenzymes take an active part in the formation of endotoxemia in people with acute small bowel obstruction. Also, in patients as a result of an imbalance between oxidant and antioxidant systems, accumulated a significant amount of lipid peroxidation products, along with it a decrease activity of enzymes of antioxidant system. reamberin application in complex treatment of acute small bowel obstruction provided the reduction in the time correction of oxidative stress by preventing the growth and activity of lipid peroxidation products with simultaneous stimulation of the antioxidant system and contributed to the normalization of microelement homeostasis.


Assuntos
Obstrução Intestinal , Intestino Delgado , Peroxidação de Lipídeos/efeitos dos fármacos , Meglumina/análogos & derivados , Estresse Oxidativo/efeitos dos fármacos , Succinatos/administração & dosagem , Doença Aguda , Adulto , Antioxidantes/administração & dosagem , Feminino , Homeostase/efeitos dos fármacos , Humanos , Obstrução Intestinal/metabolismo , Obstrução Intestinal/fisiopatologia , Obstrução Intestinal/cirurgia , Intestino Delgado/patologia , Intestino Delgado/fisiopatologia , Masculino , Meglumina/administração & dosagem , Pessoa de Meia-Idade , Resultado do Tratamento
12.
Khirurgiia (Mosk) ; (4): 51-55, 2017.
Artigo em Russo | MEDLINE | ID: mdl-28418369

RESUMO

AIM: Studying influence of remaxol on reparative process of tissue reparation in a laparotomy wound. MATERIAL AND METHODS: 90 patients with the acute appendicitis complicated by local peritonitis in the early postoperative period are examined. 50 patients received traditional therapy. Therapy of other 40 patients included Remaxol (intravenous introduction, daily within 5 days, of 400 ml). RESULTS AND CONCLUSION: It is established that Remaxol optimizes the course of reparative process in laparotomy wound that was confirmed with data of tenziomety and wound exudate cytological research. Efficiency of a Remaxol is based on its capability to improve microcirculation, antiedematous action and its capability to reduce excessive intensity peroxide oxidation of membrane lipids, phospholipase activity and the phenomena of a hypoxia.


Assuntos
Antioxidantes/administração & dosagem , Apendicite/cirurgia , Peritonite/etiologia , Succinatos/administração & dosagem , Ferida Cirúrgica/tratamento farmacológico , Cicatrização/efeitos dos fármacos , Apendicite/complicações , Humanos , Infusões Intravenosas , Laparotomia , Ferida Cirúrgica/fisiopatologia , Resultado do Tratamento , Cicatrização/fisiologia
13.
Adv Gerontol ; 30(5): 757-764, 2017.
Artigo em Russo | MEDLINE | ID: mdl-29322745

RESUMO

We conducted a study of 220 patients in polyclinic № 91 in St. Petersburg. It was revealed that elderly patients with osteochondrosis are characterized by a high prevalence and severity of osteochondrosis against the background of metabolic disorders in the structures of the spine. At the same time, the actual condition of the spine does not always determine the severity of the pain syndrome. The effect of osteochondrosis on the development of comorbid pathology has been clarified. The ways of correction of the clinical and psychophysiological status of elderly patients with osteochondrosis such as appointment of Cytoflavin, behavioral therapy and biofeed back therapy are suggested.


Assuntos
Osteocondrose da Coluna Vertebral/psicologia , Idoso , Terapia Comportamental , Combinação de Medicamentos , Mononucleotídeo de Flavina/uso terapêutico , Humanos , Inosina Difosfato/uso terapêutico , Niacinamida/uso terapêutico , Federação Russa , Osteocondrose da Coluna Vertebral/patologia , Osteocondrose da Coluna Vertebral/terapia , Coluna Vertebral/patologia , Succinatos/uso terapêutico
14.
Angiol Sosud Khir ; 22(3): 9-15, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27626244

RESUMO

Presented herein is a review of scientific publications dedicated to studying the pharmacodynamics of L-arginine and possibilities of its clinical application. Interest to L-arginine is associated, first of all, with its role as a precursor in endogenous synthesis of nitric oxide (NO), playing an important role in regulation of the functional state of the vascular wall. According to numerous studies, oral and parenteral administration of L-arginine restores endothelial production of NO in such diseases as atherosclerosis, hypertension, type 2 diabetes mellitus, obliterating diseases of arteries of lower extremities. The NO-mediated effect of L-arginine manifests itself in increasing the capability of vessels to dilatation, decreasing blood platelet aggregation, and inhibiting proliferation of smooth muscle cells of vessels. The effect is most pronounced in patients presenting with hypercholesterolaemia and initially decreased reactivity of the blood channel. The mostly pronounced NO-mediated effect of L-arginine is observed in parenteral route of its administration. Prolonged administration of L-arginine slows down progression of atherosclerosis.


Assuntos
Arginina , Doenças Cardiovasculares , Endotélio Vascular , Arginina/metabolismo , Arginina/farmacologia , Doenças Cardiovasculares/tratamento farmacológico , Doenças Cardiovasculares/metabolismo , Vias de Administração de Medicamentos , Endotélio Vascular/efeitos dos fármacos , Endotélio Vascular/metabolismo , Humanos , Óxido Nítrico/metabolismo
15.
Eksp Klin Farmakol ; 79(2): 34-9, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27416681

RESUMO

The influence of angioprotector and endothelium-protector drugs pentoxifylline and unifuzol as components of supportive therapy on the efficacy of combined cytostatic treatment has been experimentally studied. It is established that pentoxifylline and unifuzol do not affect the antitumor and antimetastatic activity of doxorubicin and cyclophosphan with respect to Pliss lymphosarcoma and Walker 256 carcinosarcoma, and in some cases even potentiate the effect of cytostatic therapy.


Assuntos
Inibidores da Angiogênese/farmacologia , Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia , Ácido Argininossuccínico/farmacologia , Carcinoma 256 de Walker/tratamento farmacológico , Citostáticos/farmacologia , Linfoma não Hodgkin/tratamento farmacológico , Pentoxifilina/farmacologia , Animais , Carcinoma 256 de Walker/patologia , Proliferação de Células/efeitos dos fármacos , Ciclofosfamida/farmacologia , Doxorrubicina/farmacologia , Sinergismo Farmacológico , Linfoma não Hodgkin/patologia , Masculino , Ratos , Ratos Wistar , Carga Tumoral/efeitos dos fármacos , Ensaios Antitumorais Modelo de Xenoenxerto
16.
Khirurgiia (Mosk) ; (7): 53-57, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27459489

RESUMO

The aim of the study was to assess the effectiveness of cytoflavin inclusion in complex treatment of patients with hypoparathyroidism occurring after thyroid surgery. To do this, an analysis of treatment of 54 patients who received surgical treatment for thyroid diseases of various etiologies. Depending on the scheme of post-operative medical therapy, the patients were divided into 2 groups: group I patients (27 persons) received basic therapy according to regulatory documents, II of the group (27 patients) in addition cytoflavin intravenous drip of 10 ml to 200 ml 0.9% NaCl for 7 days. In addition to standard clinical and laboratory examination, all patients were studied and the level of active ionized Ca2+ and PTH, oxidation products of the modified protein, lipid peroxidation and antioksidazation system dynamics - 1, 3 and 7 days after surgery. It was revealed that in the first days after the surgical treatment of patients significantly reduced the levels of ionized Ca2+ and PTH that may be regarded as signs of postoperative hypoparathyroidism, as well as the activation of the system of lipid peroxidation and antioxidant system depression. Turning cytoflavin in drug regimens improved the efficiency of the treatment, which was manifested in arresting to 7 days of monitoring signs of hypoparathyroidism, improve tissue oxygenation and restoring the balance by reducing the activity of the system of lipid peroxidation and antioxidant system strengthening.


Assuntos
Mononucleotídeo de Flavina/administração & dosagem , Hipotireoidismo , Inosina Difosfato/administração & dosagem , Peroxidação de Lipídeos/efeitos dos fármacos , Niacinamida/administração & dosagem , Oxirredução/efeitos dos fármacos , Complicações Pós-Operatórias , Succinatos/administração & dosagem , Doenças da Glândula Tireoide/cirurgia , Tireoidectomia/efeitos adversos , Adulto , Cálcio/sangue , Combinação de Medicamentos , Monitoramento de Medicamentos/métodos , Feminino , Humanos , Hipotireoidismo/sangue , Hipotireoidismo/diagnóstico , Hipotireoidismo/etiologia , Infusões Intravenosas , Masculino , Pessoa de Meia-Idade , Fármacos Neuroprotetores/administração & dosagem , Hormônio Paratireóideo/sangue , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/tratamento farmacológico , Estudos Retrospectivos , Tireoidectomia/métodos , Resultado do Tratamento
17.
Eksp Klin Farmakol ; 79(1): 28-32, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27159955

RESUMO

The study was aimed to investigate the influence of drug reamberin inclusion in the treatment regimen of patients with acute Epstein-Barr virus (EBV) infection on the effectiveness of therapy. Treatment results were analyzed in a group of 70 children aged 4-15 with a diagnosis of moderate to severe EBV infection. By the method of random sampling distribution, patients were divided into two comparable groups of 35 children, which were representative with respect to gender, age, date of admission, and conducted basic therapy. Patients in the control group were treated by the conventional scheme, while the main group received basic therapy with antibacterial drug (according to indication) and symptomatic agents (antipyretics, desensitizing agents, and local antiseptics for the treatment of rotor and nasopharynx) and, in addition, obtained 1.5% reamberin solution intravenously, 10 mL/kg body weight once a day at a rate of 3-4 mL/min (the treatment course did not exceed 3 days). Treatment efficacy was assessed by a decrease in the duration of intoxication symptoms, relief of their clinical manifestations, and normalization of laboratory data (including, in addition to commonly accepted data, the levels of malonic dialdehyde, ferritin, transferrin and catalase before and after treatment).The inclusion of reamberin in the therapy of acute EBV infection in children favors (in comparison to conventional treatment regimen) more pronounced and rapid decrease the intensity of the oxidative process and improves the functioning of the antioxidant system. This was manifested by normalization of immunobiochemical indicators (reduction of malonic dialdehyde and ferritin and increase in the level of catalase) and decrease in the inflammatory response (leukocytosis, ESR, and the number of atypical mononuclear cells in the blood), This resulted in more rapid relief of the clinical manifestations of infection (sore throat, hyperthermia, lymphadenopathy, and hepatomegaly) and shortened the hospital stay by 38.5% (p < 0.05).


Assuntos
Infecções por Vírus Epstein-Barr/tratamento farmacológico , Herpesvirus Humano 4 , Meglumina/análogos & derivados , Doenças Metabólicas/tratamento farmacológico , Succinatos/administração & dosagem , Doença Aguda , Adolescente , Criança , Pré-Escolar , Infecções por Vírus Epstein-Barr/complicações , Feminino , Humanos , Masculino , Meglumina/administração & dosagem , Doenças Metabólicas/complicações
18.
Stomatologiia (Mosk) ; 95(2): 14-17, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27239991

RESUMO

The aim of the study was to evaluate the effect of combined use of Cytoflavin and cognitive therapy on the dynamics of psychosomatic status and effectiveness of the treatment of generalized periodontitis in elderly patients. The results of treatment of 103 patients aged 60 and older were analyzed. All patients received standard therapy for 10-14 days depending on the severity of the process. In addition, the patients of the main group (51 patients) received Cytoflavin: 2 tabs. 2 times a day with an interval between doses of 8-10 hours for 25 days, and cognitive therapy aimed at training alternative realistic way of life perception. Treatment results were monitored by PMA, Russell periodontal index (PI), Green-Vermillion hygienic index. Psychosomatic dynamics was assessed by means of Spielberger anxiety scale and SUN" methods of before and after a month of treatment. The inclusion in the treatment regimen of Cytoflavin and cognitive therapy had a positive impact: reduction of PMA by 61.8%, PI by 45.3% and Green-Vermillion index by 39.8%. The psychosomatic tests proved anxiety level decrease by 28.7% in terms of "reactive" anxiety and 31.5% in terms of "personal" anxiety, emotional status (21.2%), activity (21.7%) and mood (21.8%) improvement.


Assuntos
Antioxidantes/uso terapêutico , Terapia Cognitivo-Comportamental , Mononucleotídeo de Flavina/uso terapêutico , Inosina Difosfato/uso terapêutico , Niacinamida/uso terapêutico , Periodontite/terapia , Succinatos/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Terapia Combinada , Combinação de Medicamentos , Humanos , Pessoa de Meia-Idade , Periodontite/tratamento farmacológico , Periodontite/psicologia , Resultado do Tratamento
19.
Bull Exp Biol Med ; 160(4): 589-91, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26906203

RESUMO

Culture of mesenchymal stem cells isolated from the bone marrow of primates by their characteristics met the requirements of stem cells. It was shown that transplantation of allogeneic mesenchymal stem cells (2 million cells per 1 kg body weight) immediately after ligation of the left anterior descending coronary artery between the middle and upper thirds led to neovascularization and capillarization of the ischemic myocardium.


Assuntos
Terapia Baseada em Transplante de Células e Tecidos/métodos , Transplante de Células-Tronco Mesenquimais , Células-Tronco Mesenquimais/citologia , Infarto do Miocárdio/terapia , Neovascularização Fisiológica/fisiologia , Animais , Células da Medula Óssea/citologia , Vasos Coronários/cirurgia , Masculino , Papio
20.
Eksp Klin Farmakol ; 79(10): 13-17, 2016.
Artigo em Inglês, Russo | MEDLINE | ID: mdl-30085478

RESUMO

We present results of preclinical evaluation of the specific efficiency of new metabolic corrector runikhol on models of non-alcoholic fatty liver disease in laboratory rats (228 albino males of gray Wistar rats weighing 220 - 240 g). The drug based on succinic acid positively influences the key types of metabolism impaired under conditions of development of the metabolic syndrome. Results of research testify to high efficiency and good prospects of using runikhol in the treatment of metabolic syndrome accompanied by organ disorders.


Assuntos
Antimetabólitos/química , Antimetabólitos/farmacologia , Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico , Hepatopatia Gordurosa não Alcoólica/metabolismo , Ácido Succínico/química , Ácido Succínico/farmacologia , Animais , Modelos Animais de Doenças , Masculino , Hepatopatia Gordurosa não Alcoólica/induzido quimicamente , Ratos , Ratos Wistar
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