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1.
Arch Oral Biol ; 60(8): 1138-45, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26042623

RESUMO

OBJECTIVE: This study investigated the effect of a self-etching adhesive system containing an antimicrobial quaternary ammonium methacrylate polymer (QAMP) on the vascular permeability using Evans blue and laser-Doppler flowmetric methods. DESIGN: Forty rats were anesthetized and divided into groups: saline solution; Clearfil™ Protect Bond; Clearfil™ SE Bond; Clearfil™ SE Bond containing QAMP. Injections of Evans blue were administrated intravenously and the substances were injected intradermally. Immediately before injection and after 3 and 6h, was evaluated the blood flow. The animals were killed 3 and 6h after injection. The dorsal skin was dissected and experimental sites were obtained. The vascular permeability was evaluated by dye extravasation area, the dye was extracted and absorbance measured. RESULTS: Concerning the Evans blue method, Clearfil™ SE Bond containing QAMP showed an extravasation area statistically similar to Clearfil™ SE Bond and lower than Clearfil™ Protect Bond. No statistical difference was verified among experimental groups for the amount of dye extracted. Clearfil™ SE Bond containing QAMP provided better laser-Doppler flowmetric parameters than Clearfil™ Protect Bond immediately and 3h after injection. CONCLUSION: The QAMP had lower effect on the exudative phase of the inflammatory process.


Assuntos
Permeabilidade Capilar/efeitos dos fármacos , Adesivos Dentinários/química , Compostos de Amônio Quaternário/química , Cimentos de Resina/química , Animais , Azul Evans , Extravasamento de Materiais Terapêuticos e Diagnósticos , Fluxometria por Laser-Doppler , Teste de Materiais , Testes de Sensibilidade Microbiana , Ratos , Tela Subcutânea , Propriedades de Superfície
2.
J Med Food ; 17(5): 618-24, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24476217

RESUMO

Malva sylvestris L. is widely used in medicine for treatment of inflammatory processes. The plant has anti-inflammatory properties due to substances such as mucilage, flavonoids, and tannins. A mouthwash with leaves from the plant can be used for the treatment of wounds in the oral mucosa. The aim of this study was to assess the wound healing effect of Malva sylvestris L. on a palate mucosa wound in rats. After intraperitoneal anesthesia, a 4-mm-diameter excisional wound was made in the center of the palatal mucosa of 136 rats, using a punch-out biopsy tool. Eight animals were used as baseline wound. The remaining rats were divided into four groups: CO, control; OB, orabase vehicle; CX, 2% chlorhexidine; and MA, 20% Malva in orabase. At 24 h postoperatively, the animals were immobilized without anesthetic to apply 25 mg of each substance twice a day, totaling 50 mg daily. The wound areas were measured photographically and the reepithelialization rates were determined histologically (%) after 0, 3, 7, 15, and 21 days. The data were analyzed by ANOVA and Tukey post hoc test. Similar healing pattern was observed among the groups (P>.05; ANOVA). According to the methodology, Malva sylvestris L. extract had no effect on wound healing in the palatal mucosa of rats.


Assuntos
Anti-Inflamatórios/administração & dosagem , Carboximetilcelulose Sódica/análogos & derivados , Malva/química , Mucosa Bucal/lesões , Extratos Vegetais/administração & dosagem , Cicatrização/efeitos dos fármacos , Animais , Carboximetilcelulose Sódica/administração & dosagem , Etanol , Flavonoides/administração & dosagem , Masculino , Mucosa Bucal/patologia , Palato , Fitoterapia , Folhas de Planta/química , Caules de Planta/química , Ratos , Ratos Wistar , Taninos/administração & dosagem
3.
Periodontia ; 21(3): 22-32, 2011. ilus, tab
Artigo em Português | LILACS, BBO - Odontologia | ID: lil-642320

RESUMO

A perda da papila interdental pode causar alterações fonéticas, impactação alimentar e desconforto estético. A etiologia é multifatorial, podendo ou não estar associada às doenças periodontais. Quando a causa não é proveniente de doenças periodontais, a regeneração tem maiores chances de sucesso, mas para solucionar casos em que ocorre a perda de inserção, muitas técnicas cirúrgicas foram propostas para induzir a regeneração da papila interdental, porém, com resultados limitados. O objetivo deste estudo foi revisar as possíveis causas da perda de papila interdental e analisar as diferentes técnicas propostas atualmente para a sua reconstrução. Considerando que a maioria dos estudos encontrados é sobre relatos de casos, conclui-se que são necessários estudos clínicos controlados para determinar a eficácia das técnicas cirúrgicas propostas


The loss of interdental papilla may cause phonetic changes, food impaction and a esthetic discomfort. The etiology is multifactorial, and may or may not be associated with periodontal diseases. When the cause is other than bone loss, regeneration has greater chances of success. Many surgical techniques have been proposed to induce the regeneration of the interdental papilla with limited success. The aim of this study was to review and analyze the possible causes of interdental papilla loss and the different techniques currently proposed for its reconstruction. Since most of the studies are case reports, it can be concluded that controlled clinical trials are needed to determine the efficacy of the surgical techniques used for this purpose


Assuntos
Cirurgia Bucal/métodos , Estética Dentária , Gengiva , Gengiva/cirurgia , Periodontia
4.
Rev. ABENO ; 9(1): 34-38, 2009. ilus, tab
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-875011

RESUMO

O avanço científico que vem ocorrendo no Brasil elevou a necessitada de discussão sobre ética em pesquisa envolvendo seres humanos dentro das instituições de ensino superior. Para isso, a associação entre a arte persuasiva do cinema e a ética em pesquisa tem sido uma metodologia eficaz no que diz respeito ao processo de ensino-aprendizagem de alunos de graduação e pós-graduação. Assim, o objetivo deste projeto de extensão foi promover a discussão e o conhecimento sobre a ética em pesquisa envolvendo seres humanos com graduandos, pós-graduandos, professores e servidores públicos da Universidade Estadual de Ponta Grossa. Os resultados mostraram a efetividade do método, concluindo que os filmes contribuíram satisfatoriamente para o aprendizado e posicionamento ético de todos os participantes (AU).


The scientific advance that has occurred in Brazil increases the need to discuss ethics in human research within universities and research institutes. With this in mind, the association between the persuasive art of cinema and ethics research has been an effective methodology regarding the teaching and learning of undergraduate and graduate students. The aim of this extramural education project was to promote the discussion and understanding of ethics in human clinical research among undergraduate and graduate students, professors and public servants at Ponta Grossa State University. The results showed the effectiveness of this method. In conclusion, movies can contribute satisfactorily to the ethical learning and positioning of all participants (AU).


Assuntos
Humanos , Bioética/educação , Educação Superior , Ética em Pesquisa/educação , /estatística & dados numéricos , Brasil , Inquéritos e Questionários/estatística & dados numéricos
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