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1.
Vopr Pitan ; 88(5): 39-44, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31710786

RESUMO

In everyday practice, for a personalized approach to assessing nutritional status it is necessary to determine the ideal body weight of a person, but bio-impedance analysis of body composition widespread in stationary conditions in an outpatient setting is not always available. Therefore, it is necessary to use other methods for determining the ideal body weight, the results of which would be most comparable with bio-impedance analysis results. The aim of the work is a comparative analysis of various calculation methods for determining the ideal body weight and the results of bio-impedance testing. Material and methods. 830 men aged 18 to 44 years were examined. The ideal body weight was calculated by 16 common methods. The obtained results were compared with bio-impedance analysis of body composition. Results and discussion. To compare the accuracy of the coincidence of the results obtained by means of the used methods, the method of standard error of the model was used, as well as the correlation analysis was carried out, and regression models were constructed. A comparative analysis revealed the most informative methods for determining the ideal body weight, which are recommended for use in practice. Conclusion. As a result of comparing several methods for determining the ideal body weight, we can conclude that the methods closest to the determination of ideal body weight obtained by bio-impedancemetry are the methods of Borgardt, Monnerot-Dumayn and the Insurance Company "Metropolitan Life".


Assuntos
Índice de Massa Corporal , Peso Corporal , Estado Nutricional , Adolescente , Adulto , Humanos , Masculino
2.
Ter Arkh ; 91(8): 118-126, 2019 Aug 15.
Artigo em Russo | MEDLINE | ID: mdl-32598763

RESUMO

In the article the problem of the combined use of clopidogrel and various proton pump inhibitors (PPIs) in terms of cardiovascular complications risk and stent thrombosis is considered. The results of meta - analyses and a systematic reviews affecting this issue are represented in detail. The inter - drug interactions mechanisms of various PPIs with clopidogrel based on the characteristics of the metabolism in the liver cytochromes system are discussed. The authors conducted a search, systematization and analysis of studies regarding the association between cardiovascular risk and combined use of individual medications from PPI class with clopidogrel, and these results are presented in the review. Currently available data do not allow to answer the question about the differences between individual PPIs in their impact on the risk of adverse cardiovascular events due to the small number of such studies, design heterogeneity, differences in the inclusion criteria and end points as well as in the rate of administration of individual PPIs.


Assuntos
Doenças Cardiovasculares , Clopidogrel , Interações Medicamentosas , Inibidores da Agregação Plaquetária , Inibidores da Bomba de Prótons , Doenças Cardiovasculares/induzido quimicamente , Clopidogrel/efeitos adversos , Quimioterapia Combinada , Humanos , Inibidores da Agregação Plaquetária/efeitos adversos , Inibidores da Bomba de Prótons/efeitos adversos , Ticlopidina , Resultado do Tratamento
3.
Zh Vopr Neirokhir Im N N Burdenko ; 77(1): 24-8; discussion 29, 2013.
Artigo em Inglês, Russo | MEDLINE | ID: mdl-23659117

RESUMO

Brain metastases (BM) are the most frequent intracranial SOL and extremely heterogeneous group of tumours from morphological point of view. Nevertheless, studies devoted to BM up to now paid little attention to the histogenesis of the primary tumour. Lung carcinoma is the most common source of BM; morpologically this is a very heterogeneous group of tumors, and they demostrate different clinical pathway and outcome. The aim of present study was to evaluate clinical and morphological prognostic factors in 126 patients with lung carcinoma metastases to the brain, operated in 2004-2010 at Burdenko Neurosurgical Institute. Statistical analysis demonstrated that age, gender, amount and location of BM, primary operation and even histological tumour type were not significant prognostic factors, meanwhile absence of extracranial metastases and Karnofsky index above 70 were significant factors of the favorable prognosis.


Assuntos
Neoplasias Encefálicas/secundário , Neoplasias Pulmonares/patologia , Adulto , Idoso , Biomarcadores Tumorais/análise , Neoplasias Encefálicas/mortalidade , Neoplasias Encefálicas/cirurgia , Proteínas de Ligação a DNA/biossíntese , Feminino , Humanos , Imuno-Histoquímica , Estimativa de Kaplan-Meier , Avaliação de Estado de Karnofsky , Queratina-5/biossíntese , Queratina-6/biossíntese , Neoplasias Pulmonares/mortalidade , Neoplasias Pulmonares/cirurgia , Masculino , Pessoa de Meia-Idade , Fatores de Transcrição
4.
Artigo em Russo | MEDLINE | ID: mdl-23035562

RESUMO

The influence of changes in the state of a number of neurotransmitter and peptidergic brain systems on the circadian rhythms and behaviour of rats was studied. Prolylleucine (oxytocine dipeptide fragment) eliminates disorders of circadian motility rhythm in SHR rats induced by "injection" stress, impedes dysrhythmias caused by application of cholinergic and glutamatergic modulators in SHR and WKY rats, and prevents cognitive disorders in SHR rats produced by REM sleep deprivation.


Assuntos
Encéfalo/fisiologia , Ritmo Circadiano/fisiologia , Ocitocina/fisiologia , Fases do Sono/fisiologia , Transmissão Sináptica/fisiologia , Animais , Arecolina/farmacologia , Comportamento Animal , Encéfalo/efeitos dos fármacos , Ritmo Circadiano/efeitos dos fármacos , Dipeptídeos/farmacologia , Maleato de Dizocilpina/farmacologia , Habituação Psicofisiológica/efeitos dos fármacos , Masculino , Ocitocina/farmacologia , Ratos , Ratos Endogâmicos SHR , Ratos Endogâmicos WKY , Ratos Wistar , Escopolamina/farmacologia , Fases do Sono/efeitos dos fármacos , Transmissão Sináptica/efeitos dos fármacos
5.
Eksp Klin Farmakol ; 75(8): 21-4, 2012.
Artigo em Russo | MEDLINE | ID: mdl-23012991

RESUMO

Results of a preclinical study of the anxiolytic activity and safety of original Racium phytomedicine are presented. The preparation possessed high anxiolytic activity, exhibits a wide range of therapeutic effects, produces no lethality in male and female rats and mice upon single intragastric and intraperitoneal introduction in doses up to 5 g/kg (VI class of toxicity according to OECD), induces no pathologic effects upon prolonged (120 days) administration in these rodents, and has no local irritant and/or allergen action.


Assuntos
Ansiolíticos/uso terapêutico , Ansiedade/tratamento farmacológico , Melissa/química , Mentha piperita/química , Fitoterapia , Extratos Vegetais/uso terapêutico , Valeriana/química , Animais , Ansiolíticos/administração & dosagem , Ansiolíticos/química , Ansiedade/fisiopatologia , Ansiedade/psicologia , Cromatografia Líquida de Alta Pressão , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Feminino , Injeções Intraperitoneais , Intubação Gastrointestinal , Dose Letal Mediana , Masculino , Camundongos , Extratos Vegetais/administração & dosagem , Extratos Vegetais/química , Ratos , Sesquiterpenos/análise
6.
Artigo em Russo | MEDLINE | ID: mdl-20469597

RESUMO

Circadian rhythms of horizontal and vertical motor activity and characteristic features of stress dysrhythmia caused by territorial conflict were assessed in ICR outbred mice with polar zoosocial status. The rhythms of diurnal motility of non-stressed dominant and submissive mice do not differ considerably. The territorial conflict causes desynchronosis in both high- and low-ranking animals, manifesting itself through the shift of the acrophase of motor activity and change in spectral parameters of a chronogram.


Assuntos
Ritmo Circadiano , Atividade Motora , Predomínio Social , Estresse Psicológico , Territorialidade , Animais , Masculino , Camundongos , Camundongos Endogâmicos ICR
7.
Eksp Klin Farmakol ; 72(6): 15-7, 2009.
Artigo em Russo | MEDLINE | ID: mdl-20095393

RESUMO

The influence of the original dipeptide drug noopept, known to possess nootrope, neuroprotector, and anxiolytic properties, on the anticonvulsant activity of the antiepileptic drug valproate has been studied on the model of corazole-induced convulsions in mice. Neither a single administration of noopept (0.5 mg/kg, i.p.) nor its repeated introduction in 10 or 35 days enhanced the convulsant effect of corazole, which is evidence that noopept alone does not possess anticonvulsant properties. Prolonged (five weeks) preliminary administration of noopept enhanced the anticonvulsant activity of valproate. This result justifies the joint chronic administration of noopept in combination with valproate in order to potentiate the anticonvulsant effect of the latter drug. In addition, the administration of noopept favorably influences the cognitive functions and suppresses the development of neurodegenerative processes.


Assuntos
Anticonvulsivantes/farmacologia , Dipeptídeos/farmacologia , Fármacos Neuroprotetores/farmacologia , Nootrópicos/farmacologia , Convulsões/tratamento farmacológico , Ácido Valproico/farmacologia , Animais , Anticonvulsivantes/agonistas , Convulsivantes/efeitos adversos , Convulsivantes/farmacologia , Dipeptídeos/agonistas , Sinergismo Farmacológico , Masculino , Camundongos , Nootrópicos/agonistas , Pentilenotetrazol/efeitos adversos , Pentilenotetrazol/farmacologia , Convulsões/induzido quimicamente , Fatores de Tempo , Ácido Valproico/agonistas
8.
Arkh Patol ; 69(4): 43-8, 2007.
Artigo em Russo | MEDLINE | ID: mdl-17926578

RESUMO

According to the order of the Ministry of Health and Social Development, Professor O. D. Mishnev is appointed principal pathologist of the Ministry. The principle pathologists of federal districts are Professor I. A. Kazantseva (Central Federal District); Prof. N. M. Anichkov, Corresponding Member of the Russian Academy of Medical Sciences (North-Western Federal District); Prof. I. S. Derizhanova (Southern Federal District), Prof. T. A. Fedorina (Volga Federal District), Prof. V. L. Kovalenko, Corresponding Member of the Russian Academy of Medical Sciences (Urals Federal District); Prof. L. M. Nepomnyashchikh (Siberian Federal District), and Prof. Yu. V. Kaminsky (Far-Eastern Federal District). The above specialists and the principal pathologists of the Health Departments of Moscow and St. Petersburg Prof. O. V. Zairatyants and Prof. M. G. Rybakova make up a working group whose objective is to develop standards of postmortem studies, to coordinate, and to analyze the activities of postmortem services of the country. The role of principal pathologists of the bodies (ministries, departments, committees) of health care of federal districts, republics, territories, and regions is essential. It is necessary to set up a federal organizational-and-methodical center for postmortem studies under the Ministry of Health and Social Development. The chief results of the activities of postmortem services of Russia and federal districts over 6 years (2000-2005) are presented. The shortcomings and trends of postmortem services of the country are outlined.


Assuntos
Patologia/organização & administração , Autopsia , Humanos , Federação Russa , Recursos Humanos
10.
Bull Exp Biol Med ; 132(4): 959-62, 2001 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11782792

RESUMO

Experiments on rats trained passive avoidance task showed that N-phenyl-acetyl-L-prolyl-glycyl ethyl ester, peptide analog of piracetam (GVS-111, Noopept) after oral administration retained antiamnesic activity previously observed after its parenteral administration. Effective doses were 0.5-10 mg/kg. Experiments on a specially-developed model of active avoidance (massive one-session learning schedule) showed that GVS-111 stimulated one-session learning after single administration, while after repeated administration it increased the number of successful learners among those animals who failed after initial training. In this respect, GVS-111 principally differs from its main metabolite cycloprolylglycine and standard nootropic piracetam.


Assuntos
Dipeptídeos/administração & dosagem , Dipeptídeos/farmacologia , Fármacos Neuroprotetores/administração & dosagem , Fármacos Neuroprotetores/farmacologia , Nootrópicos/administração & dosagem , Nootrópicos/farmacologia , Prolina/química , Administração Oral , Animais , Aprendizagem da Esquiva , Relação Dose-Resposta a Droga , Aprendizagem/efeitos dos fármacos , Ratos
11.
Artigo em Russo | MEDLINE | ID: mdl-10822844

RESUMO

The effects of a single and repetitive administration of m-cholinoblocker scopolamine (Sc) to male rats on retention of step-through passive avoidance (PA) or active avoidance (AA) in a shuttle-box were compared. In case of PA Sc (1 mg/kg) was injected i.p. only 30 min before training, only 30 min before testing, or both before training and before testing. In case of AA Sc (0.5 mg/kg/day) was injected i.p. only 15 min before each training session or both before training and before testing (44 days after achievement of learning criterion). The PA and AA retention were impaired only in the experiments, where the drug was administered before training, but did not differ from control, when Sc was injected twice. The Sc-induced amnesia (like many other cases of memory deficits) is suggested to be a manifestation of state-dependent learning. Similarity between the brain state during memory consolidation and during the retention test is necessary for recollection.


Assuntos
Amnésia/induzido quimicamente , Aprendizagem da Esquiva/efeitos dos fármacos , Antagonistas Muscarínicos/farmacologia , Escopolamina/farmacologia , Estimulação Acústica , Amnésia/fisiopatologia , Animais , Aprendizagem da Esquiva/fisiologia , Distribuição de Qui-Quadrado , Condicionamento Clássico/efeitos dos fármacos , Condicionamento Clássico/fisiologia , Relação Dose-Resposta a Droga , Masculino , Atividade Motora/efeitos dos fármacos , Atividade Motora/fisiologia , Antagonistas Muscarínicos/administração & dosagem , Limiar da Dor/efeitos dos fármacos , Limiar da Dor/fisiologia , Ratos , Tempo de Reação/efeitos dos fármacos , Tempo de Reação/fisiologia , Escopolamina/administração & dosagem , Estatísticas não Paramétricas
14.
Vestn Oftalmol ; 112(1): 31-2, 1996.
Artigo em Russo | MEDLINE | ID: mdl-8659066

RESUMO

Safe doses of low-intensive infrared laser (LIIL) exposure for the structures of the eye were searched for in rabbit experiments, and the potentials of such lasers in ophthalmology were assessed. Uzor, a therapeutic laser device with gamma = 0.89 mm, was employed. The doses varied from 0.0001 to 1.0 J/cm2, this corresponding to exposure duration of 0.3 to 45 min. Experiments were carried out on 20 animals. The right eyes were exposed, and the left ones were control. An increase of intraocular pressure was recorded at a dose of 0.1 J/cm2 (4.5 min) and higher; morphological study showed dilated, well-filled and newly formed vessels in the ciliary body and iris, as well as edema and destruction of the external layers of the retina. Exposure to a dose of 0.05 J/cm2 and lower did not lead to destruction of ocular structures and increase of intraocular pressure. The maximal LIIL dose causing no side effects for the organ of vision was established at 0.05 J/cm2, this corresponding to 2.5 min exposure.


Assuntos
Oftalmopatias/radioterapia , Olho/efeitos da radiação , Terapia a Laser , Animais , Iris/efeitos da radiação , Coelhos , Doses de Radiação , Retina/efeitos da radiação
15.
Eksp Klin Farmakol ; 56(6): 8-11, 1993.
Artigo em Russo | MEDLINE | ID: mdl-8111305

RESUMO

Two-hour hypobaric hypoxia of rats on day 15 of their pregnancy led to a reduction in weight gain of pups within 20 days after birth, disturbed memory in active and passive paradigms, changed adaptive behavior in the extrapolatory water avoidance test, and impaired sleep in adult animals. Postnatal treatment with sodium hydroxybutyrate given in a dose of 50 mg/kg/day on days 8 to 20 of life normalized mnestic functions of the brain, the process of falling asleep, and physical development which had been impaired by intrauterine hypoxia.


Assuntos
Sistema Nervoso Central/efeitos dos fármacos , Hipóxia Fetal/tratamento farmacológico , Efeitos Tardios da Exposição Pré-Natal , Oxibato de Sódio/farmacologia , Animais , Câmaras de Exposição Atmosférica , Sistema Nervoso Central/fisiopatologia , Condicionamento Clássico/efeitos dos fármacos , Avaliação Pré-Clínica de Medicamentos , Reação de Fuga/efeitos dos fármacos , Feminino , Hipóxia Fetal/fisiopatologia , Masculino , Memória/efeitos dos fármacos , Gravidez , Ratos , Tempo de Reação/efeitos dos fármacos , Oxibato de Sódio/uso terapêutico , Fatores de Tempo
16.
Biull Eksp Biol Med ; 115(1): 43-5, 1993 Jan.
Artigo em Russo | MEDLINE | ID: mdl-8054576

RESUMO

Hypobaric hypoxia of the pregnant rats was followed by the reduction of weight gain of the newborn pups, delayed impairment of memory (passive and active tasks) and changes of extrapolative water escape. Piracetam (200 mg/kg/day) administered at early postnatal period (from 8th to 20th day of life) corrected behavioral disturbances and physical development in rats. Postnatal therapy by nootropics didn't influence in adaptive behavior damaged by prenatal hypoxia.


Assuntos
Comportamento Animal/efeitos dos fármacos , Hipóxia Fetal/complicações , Deficiências da Aprendizagem/tratamento farmacológico , Transtornos da Memória/tratamento farmacológico , Piracetam/uso terapêutico , Efeitos Tardios da Exposição Pré-Natal , Animais , Feminino , Deficiências da Aprendizagem/etiologia , Transtornos da Memória/etiologia , Gravidez , Ratos
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