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1.
J Nutr Biochem ; 77: 108253, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31835147

RESUMO

Excess high-fat diet (HFD) intake predisposes the occurrence of obesity-associated heart injury, but the mechanism is elusive. Fisetin (FIS), as a natural flavonoid, has potential activities to alleviate obesity-induced metabolic syndrome. However, the underlying molecular mechanisms of FIS against HFD-induced cardiac injury remain unclear. The present study was to explore the protective effects of FIS on cardiac dysfunction in HFD-fed mice. We found that FIS alleviated HFD-triggered metabolic disorder by reducing body weight, fasting blood glucose and insulin levels, and insulin resistance. Moreover, FIS supplements significantly alleviated dyslipidemia in both mouse hearts and cardiomyocytes stimulated by metabolic stress. FIS treatment abolished HFD-induced inflammatory response in heart tissues through suppressing TNF receptor-1/TNF receptor-associated factor-2 (Tnfr-1/Traf-2) signaling. Furthermore, FIS induced a strong reduction in the expression of fibrosis-related genes, contributing to the inhibition of fibrosis by inactivating transforming growth factor (Tgf)-ß1/Smads/Erk1/2 signaling. Collectively, these results demonstrated that FIS could be a promising therapeutic strategy for the treatment of obesity-associated cardiac injury.

2.
Genomics ; 112(1): 683-693, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31075388

RESUMO

BACKGROUND: Recent studies discovered many genetic variants associated with both psychiatric and inflammatory disorders, but the role of genetic factors in the development of psychiatric comorbidity (PC) in inflammatory bowel disease (IBD) is underexplored. Particularly, it has been shown that some of the genetic variants have been linked to the concentrations of circulating cytokines and symptoms of the inflammatory cytokine-associated depression. We analysed genomic features of individuals with IBD by comparing IBD patients with PC with those who have IBD but without PC. We hypothesized that cytokine related signalling pathways may be significantly associated with the psychiatric comorbidity in patients with IBD. METHODS: Individuals enrolled in the Manitoba IBD Cohort Study were separated to two groups accordingly to the presence of PC. A sample set comprising 97 IBD individuals with PC (IBD + PC) and 146 IBD individuals without PC (IBD) was first used to identify copy number variations (CNVs) from genome-wide genetic data using three different detection algorithms. IBD + PC and IBD groups were compared by the number of CNVs overlapping each gene; deletions and duplications were analysed separately. Gene set overrepresentation analysis was then conducted using CNV-overlapped genes and the candidate gene sets of neurological and immunological relevance. RESULTS: Medium-sized CNV (size between 100 and 500 kilobase pairs)-burden is significantly higher in IBD + PC than IBD groups. Gene-based CNV association analysis did not show significant differences between the two IBD groups. Gene set overrepresentation analysis demonstrated the significant enrichment of gene sets related to cytokine signalling pathways by the genes overlapped by deletions in the IBD individuals with PC. CONCLUSION: Our results confirm the role of cytokine signalling pathways in the development of PC in IBD. Additionally, our results warrant further study with a larger sample size focusing on cytokine SNPs to further understand the relationship between inflammatory and psychiatric disorders.

3.
Data Brief ; 25: 104203, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31338399

RESUMO

Genome-wide copy-number association studies offer new opportunities to identify the mechanisms underlying complex diseases, including chronic inflammatory, psychiatric disorders and others. We have used genotyping microarrays to analyse the copy-number variants (CNVs) from 243 Caucasian individuals with Inflammatory Bowel Disease (IBD). The CNV data was obtained by using multiple quality control measures and merging the results of three different CNV detection algorithms: PennCNV, iPattern, and QuantiSNP. The final dataset contains 4,402 CNVs detected by two or three algorithms independently with high confidence. This paper provides a detailed description of the data generation and quality control steps. For further interpretation of the data presented in this article, please see the research article entitled 'Copy number variation-based gene set analysis reveals cytokine signalling pathways associated with psychiatric comorbidity in patients with inflammatory bowel disease'.

4.
Nanoscale ; 11(26): 12610-12618, 2019 Jul 14.
Artigo em Inglês | MEDLINE | ID: mdl-31232406

RESUMO

In the past decade, tremendous efforts have been devoted to the search for the alternatives to Pt-based catalysts for the oxygen reduction reaction (ORR) in fuel cells and metal-air batteries. Recently, metal-nitrogen-carbon (M-N-C) systems, especially 3d transition metals (TM) and their alloys encapsulated in nitrogen-doped carbon based materials (TM@N-C), have attracted increasing attention due to their low cost and high ORR activity. Here, a simple and novel strategy is developed to synthesize sandwich-structured TM@N-C composites, in which ultrafine Fe nanoparticles are encapsulated in nitrogen-doped carbon nanotubes (N-CNTs) grafted on both sides of reduced graphene oxide (rGO) sheets by pyrolysis of ammonium ferric citrate-functionalized zeolitic imidazolate framework-8@graphene oxide (Fe@ZIF-8@GO). The resulting Fe@N-CNTs@rGO composites naturally integrate zero-dimensional (0D) Fe nanoparticles, one-dimensional (1D) N-CNTs, and two-dimensional (2D) graphene into a three-dimensional (3D) hierarchical architecture with highly dispersed active sites, a large surface area, and abundant porosity. Because of these structural advantages, the sandwich-structured Fe@N-CNTs@rGO composites display a half-wave potential of 0.83 V in a 0.1 M KOH solution for the ORR, comparable to that of commercial Pt/C catalysts, and more excellent durability and resistance to fuel molecules. The proposed strategy paves a new way for the synthesis of non-precious high-performance electrocatalysts for energy conversion applications.

5.
PLoS One ; 14(6): e0217846, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31185018

RESUMO

BACKGROUND: Inflammatory bowel disease (IBD) is an idiopathic, chronic disorder of unclear etiology with an underlying genetic predisposition. Recent genome-wide association studies have identified more than 200 IBD susceptibility loci, but the causes of IBD remain poorly defined. We hypothesized that rare (<0.1% population frequency) gene copy number variations (CNVs) could play an important mechanism for risk of IBD. We aimed to examine changes in DNA copy number in a population-based cohort of patients with IBD and search for novel genetic risk factors for IBD. METHODS: DNA samples from 243 individuals with IBD from the Manitoba IBD Cohort Study and 2988 healthy controls were analyzed using genome-wide SNP microarray technology. Three CNV calling algorithms were applied to maximize sensitivity and specificity of CNV detection. We identified IBD-associated genes affected by rare CNV from comparing the number of overlapping CNVs in IBD samples with the number of overlapping CNVs in controls for each gene. RESULTS: 4,402 CNVs detected by two or three algorithms intersected 7,061 genes, in at least one analyzed sample. Four genes (e.g. DUSP22 and IP6K3) intersected by rare deletions and fourteen genes (e.g. SLC25A10, PSPN, GTF2F1) intersected by rare duplications demonstrated significant association with IBD (FDR-adjusted p-value < 0.01). Of these, ten genes were functionally related to immune response and intracellular signalling pathways. Some of these genes were also identified in other IBD related genome-wide association studies. These suggested that the identified genes may play a role in the risk of IBD. CONCLUSION: Our results revealed new genomic loci associated with IBD, which suggested the role of rare CNVs in IBD risk.


Assuntos
Variações do Número de Cópias de DNA , Dosagem de Genes , Loci Gênicos , Predisposição Genética para Doença , Doenças Inflamatórias Intestinais/genética , Polimorfismo de Nucleotídeo Único , Adulto , Estudos de Coortes , Feminino , Estudo de Associação Genômica Ampla , Humanos , Masculino , Manitoba , Estudos Prospectivos
6.
Chem Commun (Camb) ; 55(34): 4989-4992, 2019 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-30968889

RESUMO

Hollow porous rhodium (Rh) nanoballs are prepared via a facile one-pot reaction. They are porous and possess dendritic exteriors, and it is easy to get them with a clean surface. Owing to the structrual advantages, they exhibit superior electrochemical catalytic activity and structural stability to the commercial Pt black towards ethanol electro-oxidation in alkaline medium.

7.
Dalton Trans ; 48(17): 5515-5519, 2019 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-30946402

RESUMO

Highly distributed Pd NPs supported on the surface of sulfonic acid functionalized metal organic frameworks (MIL-101-SO3H) were synthesized via a simple thermal decomposition method. The as-synthesized Pd/MIL-101-SO3H was used to catalyze a hydrogenation/esterification cascade reaction for the conversion of biomass derivatives (furoic acid) into high value chemicals (ethyl tetrahydro-2-furoate).

8.
Nanoscale ; 11(7): 3292-3299, 2019 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-30720824

RESUMO

Tandem catalysis (i.e., a process in which a desirable product is synthesized by a one-step process consisting of sequential reactions) has attracted intensive attention owing to its sustainable green and atom-economical characteristics. In this process, the utilization of a high-efficiency multifunctional catalyst is key. However, different functional sites integrated within the catalyst are required to be rationally designed and precisely engineered to guarantee the synergy between the catalytic reactions. Herein, a novel kind of hydrogenation-esterification tandem catalyst with metal/acid (alloy/polyoxometalates) active sites integrated within the metal-organic frameworks (MOFs) was prepared by a facile self-sacrificial template route. In this tandem catalyst, the MOF cavities served as tandem reactors, the PtNi alloy sites encapsulated within the MOF material acted as hydrogenation sites, and the solid phosphotungstic acid embedded in the MOF cavities provided esterification sites. This well-designed tandem catalyst showed outstanding activity and selectivity towards the one-step synthesis of amino-ester-type anesthetics (e.g., benzocaine) owing to the synergistic catalysis of the metal and acid sites. Clearly, this novel tandem catalyst simplifies the traditional industry process and provides a new method to rationally construct new tandem catalysts.

9.
Acc Chem Res ; 51(11): 2880-2887, 2018 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-30346701

RESUMO

Tailoring the surface structures of nanocrystals is an exciting research area on account of appealing surface-dependent properties in various applications. Although significant progress has been made in recent years, current synthetic approaches are mainly dependent upon trial and error because of the ambiguous roles of various influencing factors in complicated environments. Therefore, a general theory for predicting and guiding the rationally controlled synthesis of micro- and nanocrystallites with specific surface structures is highly desired. Of note, previous research attention was mainly focused on the crystal growth in near equilibrium conditions. However, in supersaturated growth environments (nonequilibrium conditions), the corresponding crystal growth theories are still limited. Recently, the supersaturation-controlled surface structure strategy, which is derived from thermodynamics and the Thomson-Gibbs equation, has opened up a new avenue for the control the surface structures of crystals. This strategy involves manipulating the supersaturation of growth units to control the surface structure of micro- and nanocrystallites, as the surface energy of exposed facets is correlated to the supersaturation of growth blocks. Based on the proposed theory, micro- and nanocrystallites with various surface structures, especially high-energy facets, have been successfully synthesized by our group and other researchers in past years. In order to draw lessons from previous studies, it is imperative to give a timely research account related to the supersaturation strategy and corresponding applications in controlling surface structures of different crystallites. In this Account, we explore the supersaturation-controlled surface structure strategy to construct functional nanomaterials with desired architectures. First, we highlight the role of supersaturation of growth units from theoretical analysis after a short introduction of fundamental principles for crystal growth. Then, some detailed cases concerning evolution of surface structures are presented to highlight the key experimental factors involved in manipulating the supersaturation of growth units during synthetic processes. These factors include solvents, reaction rates, and additives in wet chemical routes as well as overpotential in electrochemical routes. In addition, we briefly discuss the role of supersaturation in growth kinetics with focus on explaining the formation of spherical micro- and nanocrystallites at extremely high supersaturation. Finally, a general summary of the supersaturation-dependent surface structure control and future prospects in this field are provided. It is expected that this Account will deepen the current understanding on fundamental principles behind the control of surface structures of micro- and nanocrystallites, which can help us to construct desirable nanomaterials and promote their practical applications.

10.
Chem Commun (Camb) ; 54(77): 10855-10858, 2018 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-30199081

RESUMO

Icosahedra have small contact areas during packing, leading small icosahedral Pt nanoparticles to highly disperse on carbon nanotubes (CNT). The as-synthesized highly monodispersed Pt icosahedra on CNT exhibited superior catalytic activity and structural stability to their Pt nanocube counterparts on CNT towards methanol electro-oxidation.

11.
ACS Appl Mater Interfaces ; 10(34): 28839-28849, 2018 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-30079724

RESUMO

Due to the increasing demand for military and commercial applications, magnetic metal-based core@shell nanostructures have attracted extensive attention in the field of electromagnetic wave (EMW) absorption materials. To further improve the overall performance, herein, an effective strategy is designed to fabricate Co3Fe7@C yolk-shell structures by using (Co0.9Fe0.1)Fe2O4@phenolic resin core@shell structures as precursors. The structure parameters, including the size of the CoFe alloy cores, the thickness of the carbon shell, and the void between the core and the shell, can be tailored by controlling the reaction conditions. It is demonstrated that the EMW absorption properties of the as-prepared Co3Fe7@C yolk-shell structures are closely related to their structure parameters. The optimized Co3Fe7@C yolk-shell structure shows excellent EMW absorption performance, the strongest reflection loss (RL) is up to -35.3 dB at 9.1 GHz with the matching thickness of 2.0 mm, and the effective bandwidth (RL < -10 dB) can reach 8.4 GHz (9.6-18 GHz) with a thickness of only 1.5 mm. It is revealed that the excellent performances stem from the unique yolk-shell structure as well as the complementarities and synergies between the dielectric loss and the magnetic loss. By rational designing, the magnetic metal alloy@carbon yolk-shell structures will be convinced to have the potential as novel high-efficiency EMW absorption materials with lightweight, low thickness, wide absorption frequency, high stability, and strong absorption characteristics.

12.
J Am Chem Soc ; 140(36): 11232-11240, 2018 09 12.
Artigo em Inglês | MEDLINE | ID: mdl-30117323

RESUMO

Developing active and durable electro-catalysts toward ethanol oxidation reaction (EOR) with high selectivity toward the C-C bond cleavage is an important issue for the commercialization of direct ethanol fuel cell. Unfortunately, current ethanol oxidation electro-catalysts (e.g., Pt, Pd) still suffer from poor selectivity for direct oxidation of ethanol to CO2, and rapid activity degradation. Here we report a facile route to the synthesis of a new kind of cyclic penta-twinned (CPT) Rh nanostructures that are self-supported nanobranches (NBs) built with 1-dimension CPT nanorods as subunits. Structurally, the as-prepared Rh NBs possess high percentage of open {100} facets with significant CPT-induced lattice strains. With these unique structural characteristics, the as-prepared CPT Rh NBs exhibit outstanding electrocatalytic performance toward EOR in alkaline solution. Most strikingly, the selectivity of complete conversion ethanol to CO2 on the CPT Rh NBs is measured to be as high as 14.5 ± 1.1% at -0.15 V, far exceeding that for single-crystal tetrahedral nanocrystals, icosahedral nanocrystals, and commercial Rh black, as well as majority of reported values for Pt or Pd-based electro-catalysts. By combining with density functional theory calculation, the effects of different structural features of Rh on EOR are definitively elucidated. It was found that the large amount of open Rh (100) facets dominantly contribute to the outstanding activity and exceptionally high selectivity, while the additional tensile strain on (100) planes can further boost the catalytic activity by enhancing the adsorption strength and lowering the reaction barrier of dehydrogenation process of ethanol. As a proof of concept, the present work shows that rationally optimizing surface and electronic structure of electro-catalysts by simultaneously engineering their surface and bulk structures is a promising strategy to promote the performance of electro-catalysts.

13.
Nanoscale ; 10(19): 9012-9020, 2018 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-29717313

RESUMO

Solid crystalline materials have long range order in their atomic arrangement while liquids have short range order, and the transition between them is usually caused by heat and/or pressure. Herein, we report the finding that chemical processes may play a similar role as heat and initiate liquid-like behavior of crystalline nanomaterials at a temperature far below their melting points. When the straight Cu/CuAu crystalline nanocables are dispersed in organic amine at 80 °C under ambient conditions, the continuous oxidation of Cu atoms on the surface and diffusion of Cu atoms from the core to the surface would break up the long-range ordered arrangement of atoms and lead to the transformation of an anisotropic crystal into an isotropic liquid-like state, which resulted in the evolution of the straight morphology of the nanocables into periodic wavy structures following the Rayleigh instability. It was also demonstrated that periodic wavy Cu@CuAu nanocables exhibit much better catalytic activity than straight Cu@CuAu nanocables towards the reduction of p-nitrophenol into p-aminophenol by NaBH4. Our results not only provide new insights into the transition between a solid crystal and a liquid-like state at the nanoscale, but also facilitate the development of new strategies for the synthesis of functional nanomaterials.

14.
Nanoscale ; 10(4): 1930-1938, 2018 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-29319092

RESUMO

Due to their distinctive structure, inherently anisotropic properties and broad applications, Janus colloidal particles have attracted tremendous attention and it is significant to synthesize high yield Janus colloidal particles in a cost-effective and reliable way. On the other hand, due to the expanded electromagnetic interference problems, it is highly desired to develop excellent electromagnetic wave absorbing materials with an ultra-wide absorption bandwidth for practical application. Herein, a confined liquid-solid redox reaction strategy has been developed to fabricate a series of Fex(CoyNi1-y)100-x ternary alloy particles. The as-prepared particles are in the form of u-channelled noncentrosymmetric spheres, one kind of Janus colloidal particles which have been rarely observed. Due to the combination and synergy effects of multi-magnetic metals, the polycrystalline structure and their specific morphology, the as-prepared particles possess multiple magnetic resonance and multiple dielectric relaxation processes, and therefore show excellent electromagnetic wave absorption performances. In particular, the strongest reflection loss (RL) of the Fe15(Co0.2Ni0.8)85 Janus colloidal particles is up to -36.9 dB with a thickness of 2.5 mm, and the effective absorption (RL < -10 dB) bandwidth can reach 9.2 GHz (8-17.2 GHz) with a thickness of 2 mm. Such a wide bandwidth has barely been reported for magnetic metal alloys under a single thickness. These results suggest that the Fex(CoyNi1-y)100-x Janus particles could be a promising candidate for highly efficient electromagnetic wave absorbing materials for practical application.

15.
Nat Commun ; 8(1): 1261, 2017 11 02.
Artigo em Inglês | MEDLINE | ID: mdl-29093444

RESUMO

The Kirkendall effect has been recently used to produce hollow nanostructures by taking advantage of the different diffusion rates of species involved in the chemical transformations of nanoscale objects. Here we demonstrate a nanoscale Kirkendall cavitation process that can transform solid palladium nanocrystals into hollow palladium nanocrystals through insertion and extraction of phosphorus. The key to success in producing monometallic hollow nanocrystals is the effective extraction of phosphorus through an oxidation reaction, which promotes the outward diffusion of phosphorus from the compound nanocrystals of palladium phosphide and consequently the inward diffusion of vacancies and their coalescence into larger voids. We further demonstrate that this Kirkendall cavitation process can be repeated a number of times to gradually inflate the hollow metal nanocrystals, producing nanoshells of increased diameters and decreased thicknesses. The resulting thin palladium nanoshells exhibit enhanced catalytic activity and high durability toward formic acid oxidation.

16.
Small ; 13(33)2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-28675780

RESUMO

Functional nanoparticles encapsulated within metal-organic frameworks (MOFs) as an emerging class of composite materials attract increasing attention owing to their enhanced or even novel properties caused by the synergistic effect between the two functional materials. However, there is still no ideal composite structure as platform to systematically analyze and evaluate the relation between the enhanced catalytic performance of composites and the structure of MOF shells. In this work, taking RhCoNi ternary alloy nanoflowers, for example, first the RhCoNi@MOF composite catalysts sheathed with different structured MOFs via a facile self-sacrificing template process are successfully fabricated. The structure type of MOF shells is easily adjustable by using different organic molecules as etchant and coordination reagent (e.g., 2,5-dihydroxyterephthalic acid or 2-methylimidazole), which can dissolve out the Co or Ni element in the alloy template in a targeted manner, thereby producing ZIF-67(Co) or MOF-74(Ni) shells accordingly. With the difference between the two MOF shells in the aperture sizes, the as-prepared two RhCoNi@MOF composites preform distinct size selectivity during the alkene hydrogenation. This work would help us to get more comprehensive understanding of the intrinsic role of MOFs behind the enhanced catalytic performance of nanoparticle@MOF composites.

17.
Chemistry ; 23(47): 11397-11403, 2017 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-28600870

RESUMO

Noble metal nanoparticles embedded in metal-organic frameworks (MOFs) are composite catalysts with enhanced or novel properties compared to the pristine counterparts. In recent years, to determine the role of MOFs during catalytic process, most studies have focussed on the confinement effect of MOFs, but ignored the structural flexibility of MOFs. In this study, we use two composite catalysts, Pt@ZIF-8 [Zn(mIM)2 , mIM=2-methyl imidazole] with flexible structure and Pt@ZIF-71 [Zn(DClIM)2 , DClIM=4,5-dichloroimidazole] with rigid structure, and hydrogenation of cinnamaldehyde as model reaction, to show the confinement effect and the structure flexibility of MOF matrices on the catalytic performance of composite catalysts. Both catalysts showed high selectivity for cinnamic alcohol with the confinement effect of the aperture. But, compared to Pt@ZIF-71, Pt@ZIF-8 exhibited higher conversion but lower selectivity owing to the flexible structure. The above results remind us that we will have to consider both the aperture size of MOFs and structure flexibility to select the proper MOF matrices for the composite materials to achieve the optimized performance.

18.
Cancer Med ; 6(2): 361-373, 2017 02.
Artigo em Inglês | MEDLINE | ID: mdl-28074552

RESUMO

Polymorphisms in miRNA and miRNA pathway genes have been previously associated with cancer risk and outcome, but have not been studied in esophageal adenocarcinoma outcomes. Here, we evaluate candidate miRNA pathway polymorphisms in esophageal adenocarcinoma prognosis and attempt to validate them in an independent cohort of esophageal adenocarcinoma patients. Among 231 esophageal adenocarcinoma patients of all stages/treatment plans, 38 candidate genetic polymorphisms (17 biogenesis, 9 miRNA targets, 5 pri-miRNA, 7 pre-miRNA) were genotyped and analyzed. Cox proportional hazard models adjusted for sociodemographic and clinicopathological covariates helped assess the association of genetic polymorphisms with overall survival (OS) and progression-free survival (PFS). Significantly associated polymorphisms were then evaluated in an independent cohort of 137 esophageal adenocarcinoma patients. Among the 231 discovery cohort patients, 86% were male, median diagnosis age was 64 years, 34% were metastatic at diagnosis, and median OS and PFS were 20 and 12 months, respectively. GEMIN3 rs197412 (aHR = 1.37, 95%CI: [1.04-1.80]; P = 0.02), hsa-mir-124-1 rs531564 (aHR = 0.60, 95% CI: [0.53-0.90]; P = 0.05), and KIAA0423 rs1053667 (aHR = 0.51, 95% CI: [0.28-0.96]; P = 0.04) were found associated with OS. Furthermore, GEMIN3 rs197412 (aHR = 1.33, 95% CI: [1.03-1.74]; P = 0.03) and KRT81 rs3660 (aHR = 1.29, 95% CI: [1.01-1.64]; P = 0.04) were found associated with PFS. Although none of these polymorphisms were significant in the second cohort, hsa-mir-124-1 rs531564 and KIAA0423 rs1053667 had trends in the same direction; when both cohorts were combined together, GEMIN3 rs197412, hsa-mir-124-1 rs531564, and KIAA0423 rs1053667 remained significantly associated with OS. We demonstrate the association of multiple miRNA pathway polymorphisms with esophageal adenocarcinoma prognosis in a discovery cohort of patients, which did not validate in a separate cohort but had consistent associations in the pooled cohort. Larger studies are required to confirm/validate the prognostic value of these polymorphisms in esophageal adenocarcinoma.


Assuntos
Adenocarcinoma/genética , Neoplasias Esofágicas/genética , Redes Reguladoras de Genes , MicroRNAs/genética , Polimorfismo de Nucleotídeo Único , Adulto , Idoso , Idoso de 80 Anos ou mais , Intervalo Livre de Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Prognóstico , Modelos de Riscos Proporcionais , Análise de Sobrevida
19.
Cancer Inform ; 15(Suppl 2): 43-50, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27773988

RESUMO

Many cancers have been linked to copy number variations (CNVs) in the genomic DNA. Although there are existing methods to analyze CNVs from individual samples, cancer-causing genes are more frequently discovered in regions where CNVs are common among tumor samples, also known as recurrent CNVs. Integrating multiple samples and locating recurrent CNV regions remain a challenge, both computationally and conceptually. We propose a new graph-based algorithm for identifying recurrent CNVs using the maximal clique detection technique. The algorithm has an optimal solution, which means all maximal cliques can be identified, and guarantees that the identified CNV regions are the most frequent and that the minimal regions have been delineated among tumor samples. The algorithm has successfully been applied to analyze a large cohort of breast cancer samples and identified some breast cancer-associated genes and pathways.

20.
ACS Appl Mater Interfaces ; 8(45): 31059-31066, 2016 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-27783897

RESUMO

For new composite materials with functional nanoparticles (NPs) embedded in metal organic frameworks (MOFs), rational design and precise control over their architectures are imperative for achieving enhanced performance and novel functions. Especially in catalysis, the activity and selectivity of such composite materials are strongly determined by the encapsulation state and thickness of the MOF shell, which greatly influences the diffusion and adsorption of substance molecules onto the NP surface. In this study, MOF-74(Ni)-encapsulated Rh-Ni hierarchical heterostructures (Rh-Ni@MOF-74(Ni)) were successfully constructed using magnetic Rh-Ni-alloyed nanoflowers (NFs) as a self-sacrificial template. Strikingly, the encapsulation state and thickness of the formed MOF shell were well-tuned via template dealloying by changing the Ni content in the Rh-Ni NFs template. More interestingly, such unique Rh-Ni composites encapsulated with MOFs as catalysts could be magnetically recyclable and exhibited enhanced catalytic performance for the selective hydrogenation of alkynes to cis products, owing to the confinement effect of the MOF shell, as compared to their pristine counterparts.

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