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Ann R Coll Surg Engl ; 102(1): 3-8, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31858833


INTRODUCTION: Achieving a standard of clinical research at the pinnacle of the evidence pyramid is historically expensive and logistically challenging. Research collaboratives have delivered high-impact prospective multicentre audits and clinical trials by using trainee networks with a range of enabling technology. This review outlines such use of technology in the UK and provides a framework of recommended technologies for future studies. METHODS: A review of the literature identified technology used in collaborative projects. Additional technologies were identified through web searches. Technologies were grouped into themes including access (networking and engagement), collaboration and event organisation. The technologies available to support each theme were studied further to outline relative benefits and limitations. FINDINGS: Thirty-three articles from trainee research collaboratives were identified. The most frequently documented technologies were social media applications, website platforms and research databases. The Supportive Technologies in Collaborative Research framework is proposed, providing a structure for using the technologies available to support multicentre collaboration. Such technologies are often overlooked in the literature by established and start-up collaborative project groups. If used correctly, they might help to overcome the physical, logistical and financial barriers of multicentre clinical trials.

Pesquisa Biomédica/métodos , Tecnologia Biomédica/métodos , Comportamento Cooperativo , Relações Interprofissionais , Ensaios Clínicos como Assunto , Comunicação , Cirurgia Geral/educação , Humanos , Internet , Redes Sociais Online , Estudantes de Medicina
Ann Med Surg (Lond) ; 33: 1-6, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30094024


Background: Advances in digital technology hold promise in expanding the clinical and consumer applications of facial electromyography (EMG) through thedevelopment of wireless pervasive systems capable of operating in a nonclinical environment. This systematic review aims to appraise the most commonly reported limitations of the technology in clinical research and practice. Methods: A systematic search for clinical facial EMG literature was performed using MEDLINE, EMBASE, PsychINFO and CINAHL. No language limits were applied. Search results were screened using defined criteria by two authors with disagreements resolved by a third. Practical limitations in the technology, as reported by the authors, were recorded and characterised using recurrent theme analysis. Results: A total of 4,983 records were identified. Of those, 1,061 articles met eligibility criteria and were subsequently reviewed. In the medical domain, the most common area of application was in psychosocial studies (28% of medical studies); in the surgical domain monitoring of facial nerve integrity was the most common application of facial electromyography (27% of surgical studies). Collectively, the three most commonly reported limitations were motion artefact (13.7%), inter-subject variability in response and anatomy (13.1%), and muscle crosstalk (12.0%). Conclusions: This is the first study to evaluate the limitations of facial EMG using a systematic analysis of author reports. Highlighting technology limitations in this non-biased manner raises awareness to users key issues and reliably informs the development of future systems.

Dis Esophagus ; 29(3): 255-61, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25625191


Conventional catheter-based systems used for ambulatory esophageal pH monitoring have been reported to affect patient behavior. As physical activity has been associated with gastroesophageal reflux disease (GERD), there is a risk that abnormal behavior will degrade the value of this diagnostic investigation and consequent management strategies. The aim of this study was to quantify the effect of conventional pH monitoring on behavior and to investigate the temporal association between activity and reflux. A total of 20 patients listed for 24 hours pH monitoring underwent activity monitoring using a lightweight ear-worn accelerometer (e-AR sensor, Imperial College London) 2 days prior to, and during their investigation. PH was measured and recorded using a conventional nasogastric catheter and waist-worn receiver. Daily activity levels, including subject-specific activity intensity quartiles, were calculated and compared. Physical activity was added to the standard pH output to supplement interpretation. Average patient activity levels decreased by 26.5% during pH monitoring (range -4.5 to 51.0%, P = 0.036). High-intensity activity decreased by 24.4% (range -4.0 to 75.6%, P = 0.036), and restful activity increased on average by 34% although this failed to reach statistical significance (-24.0 to 289.2%, P = 0.161). Some patients exhibited consistent associations between bouts of activity and acidic episodes. The results of this study support the previously reported reduction in activity during ambulatory esophageal pH monitoring, with the added reliability of objective data. In the absence of more pervasive pH monitoring systems (e.g. wireless), quantifying activity changes in the setting of activity-induced reflux might guide the physicians' interpretation of patient DeMeester scores resulting in more appropriate management of GERD.

Acelerometria/métodos , Monitoramento do pH Esofágico/métodos , Exercício , Refluxo Gastroesofágico/diagnóstico , Monitorização Fisiológica/métodos , Acelerometria/instrumentação , Adulto , Monitoramento do pH Esofágico/instrumentação , Esôfago/metabolismo , Feminino , Humanos , Concentração de Íons de Hidrogênio , Masculino , Pessoa de Meia-Idade , Monitorização Fisiológica/instrumentação , Reprodutibilidade dos Testes
Bone Joint J ; 97-B(8): 1118-25, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26224831


In this study we quantified and characterised the return of functional mobility following open tibial fracture using the Hamlyn Mobility Score. A total of 20 patients who had undergone reconstruction following this fracture were reviewed at three-month intervals for one year. An ear-worn movement sensor was used to assess their mobility and gait. The Hamlyn Mobility Score and its constituent kinematic features were calculated longitudinally, allowing analysis of mobility during recovery and between patients with varying grades of fracture. The mean score improved throughout the study period. Patients with more severe fractures recovered at a slower rate; those with a grade I Gustilo-Anderson fracture completing most of their recovery within three months, those with a grade II fracture within six months and those with a grade III fracture within nine months. Analysis of gait showed that the quality of walking continued to improve up to 12 months post-operatively, whereas the capacity to walk, as measured by the six-minute walking test, plateaued after six months. Late complications occurred in two patients, in whom the trajectory of recovery deviated by > 0.5 standard deviations below that of the remaining patients. This is the first objective, longitudinal assessment of functional recovery in patients with an open tibial fracture, providing some clarification of the differences in prognosis and recovery associated with different grades of fracture.

Fixação de Fratura/métodos , Fraturas Expostas/cirurgia , Recuperação de Função Fisiológica/fisiologia , Fraturas da Tíbia/cirurgia , Caminhada/fisiologia , Adulto , Avaliação da Deficiência , Feminino , Fraturas Expostas/classificação , Fraturas Expostas/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Estudos Prospectivos , Fraturas da Tíbia/classificação , Fraturas da Tíbia/fisiopatologia