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1.
Clin Dermatol ; 39(1): 146-148, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33972044

RESUMO

Renowned for her self-portraiture that acts as her visual autobiography, Frida Kahlo (1907-1954) is one of the leading woman painters of all time and an enduring feminist icon. Aside from the personal and societal commentary, both subtle and overt, that is evident within her artwork, the use of medical imagery shifts the viewer's perspective beyond Kahlo's self-portraits to offer accurate interpretations of her own singular history. The incorporation of dermatologic iconography within Kahlo's self-portraiture to record her skin, as well as its unique features, have rebuked conventional standards of beauty and exploded preconceptions of what is permissible in high art.

2.
Clin Dermatol ; 39(1): 52-55, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33972053

RESUMO

Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, medical professionals have been overwhelmed by questions beyond the infection itself. In dermatology practice, clinicians have been facing difficulties about the management of chronic immune-mediated skin diseases. Issues arose, such as the grade of immunosuppression or immunomodulation, discontinuation or modification of treatment, and initiation of new treatments. In this comprehensive review, we present the current evidence about the course and management of chronic inflammatory dermatoses during the COVID-19 pandemic, focusing on psoriasis, atopic dermatitis, and hidradenitis suppurativa.

4.
Clin Case Rep ; 8(2): 393-395, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32128198

RESUMO

The presence of sebaceous neoplasm should alert physicians to thoroughly investigate for underlying malignancies. Awareness on MTS should be raised within physicians, since this may be just the thin end of the wedge.

5.
Clin Case Rep ; 8(1): 224-225, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31998525

RESUMO

The impressive clinical picture of Charcot joint reflects a high energy trauma injury which in the contrary is a progressive, painless arthropathy. Early and accurate diagnosis is crucial. A favorable outcome is elicited when joint is treated promptly, while late or misdiagnosis may lead to amputation.

6.
Clin Case Rep ; 7(7): 1454-1455, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31360512

RESUMO

The purpose of this image is to raise awareness of the early diagnosis and treatment of Blount's disease. Failure to distinguish between physiologic genu varum and early onset of Blount's disease can lead to irreversible outcomes, including progressive deformity with gait deviations, limb-length discrepancy, and premature arthritis of the knee.

7.
Case Rep Dermatol Med ; 2019: 3273987, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31179136

RESUMO

Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous adverse reaction mainly attributed to antibiotics. It is characterized by numerous, nonfollicular, sterile pustules, arising on an exanthematous and edematous base. It is a serious adverse reaction accompanied by fever and leukocytosis. Piperacillin/tazobactam is indicated for the treatment of patients with moderate to severe infections. Herein is reported a case of AGEP caused by piperacillin/tazobactam. A 78-year-old woman with metastatic breast cancer was presented to the emergency department reporting fever and groin pain. The laboratory analysis and more specifically urine cultivation showed a urinary tract infection by E. coli with sensitivity to piperacillin/tazobactam. She had no known allergies. She was started on intravenous piperacillin/tazobactam; she improved clinically on the second day, but on the fourth day of intravenous therapy, she developed extensive pustular rash on the folds and anterior proximal thighs, accompanied by fever and neutrophilia. Piperacillin/tazobactam administration was interrupted and she was given prednisolone for ten days. The patient improved clinically and her laboratory tests returned to normal after two weeks. AGEP is an uncommon side effect of piperacillin/tazobactam treatment and there are few cases reported.

8.
Exp Dermatol ; 28(8): 972-975, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31077459

RESUMO

Pemphigus vulgaris is a rare chronic blistering skin disease resulting from IgG autoantibodies directed against transmembrane desmosomal glycoprotein desmoglein 3 and is the most common form of pemphigus. Since interleukin-1 receptor-associated kinase (IRAK-1)/nuclear factor-kappa B (NF-kappa B) pathway plays an essential role in the pathogenesis of autoimmune diseases, the aim of the present study was to explore the role of polymorphisms in three genes, named IRAK1 (rs3027898), NFKBIA (rs696) and NFKB1 (-94ATTG insertion/deletion variant, - rs28362491), in PV susceptibility. Forty-four unrelated patients with PV (23 males) were enrolled in the study. Additionally, 77 ethnic matching healthy volunteers (45 males) with no personal or family history of chronic autoimmune or infectious diseases were studied. Strong statistical significant difference was observed between PV patients and controls for polymorphism -94 insertion/deletion ATTG in the promoter region of NFKB1 gene (P = 0.00005). Additional dedicated studies in larger groups of patients of various ethnicities are needed to replicate and confirm the preliminary findings.


Assuntos
Quinases Associadas a Receptores de Interleucina-1/genética , Inibidor de NF-kappaB alfa/genética , Subunidade p50 de NF-kappa B/genética , Pênfigo/genética , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo Genético , Adulto Jovem
11.
Acta Dermatovenerol Croat ; 27(1): 8-10, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31032784

RESUMO

Pemphigus is an autoimmune bullous disorder caused by autoantibodies against desmosomal cadherins. The most common clinical forms are pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Among the numerous proteins that are considered responsible for the cohesion of keratinocytes in epidermis, desmocollin-3 (Dsc-3) has been initially reported to participate in epidermal blistering in mice. There have been reports in which autoantibodies against Dsc-3 have been detected. In PV, a limited number of studies found no presence of IgG or IgA autoantibodies against Dsc-3. In this study we examined sera from Greek patients with PV and PF for the presence of IgG autoantibodies against Dsc-3. Immunoblotting for the detection of autoantibodies against Dsc-3 was performed in sera from all cases. Dsc-3 autoantibodies were not detected in either group (PV and PF). Our results confirm the hypothesis that the pathogenic role of Dsc-3 in epidermal blistering in PV and PF remains controversial.


Assuntos
Autoanticorpos/sangue , Desmocolinas/imunologia , Imunoglobulina G/sangue , Pênfigo/sangue , Estudos de Casos e Controles , Grécia , Humanos , Pênfigo/imunologia
12.
Clin Case Rep ; 7(4): 695-698, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30997066

RESUMO

Palisaded neutrophilic granulomatous dermatitis is a cutaneous marker of a systemic disease. Clinicians' goal should be directed toward determining an underlying condition. Even if the initial investigation is inconclusive, it may be necessary that some tests are repeated, since a serious underlying disease could be revealed in the course of time.

14.
Pediatr Dermatol ; 36(2): 184-188, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30569520

RESUMO

Bullous pemphigoid (BP) is the most common autoimmune blistering disease affecting the elderly but is quite rare in childhood. The majority of pediatric cases have been reported during early childhood. Adolescence is divided into three phases: early (10-13 years), middle (14-17), and late (18-21). This review aimed to identify BP cases in adolescence and demonstrate their clinical features and course. Our literature search was performed in Medline with the terms "bullous pemphigoid in childhood and adolescence," "childhood bullous pemphigoid," "juvenile bullous pemphigoid," and "autoimmune blistering and autoimmune bullous diseases in childhood." The data extraction for late adolescence was limited by the fact that this age group is included in adult BP registries. We identified nine cases in early adolescence. Mucosa were affected in 5 of 9 cases. Treatment consisted of systemic prednisone (8/9), in combination with dapsone (2/9), azathioprine (2/9), or erythromycin/nicotinamide (1/9). Relapses were reported in 3 of 9 cases. We identified five cases occuring in middle adolescence. Mucosa were not affected. Treatment consisted of systemic prednisone (5/5), in combination with dapsone (3/5), azathioprine (2/5), doxycycline/nicotinamide (1/5), or mycophenolate mofetil (1/5). Relapses were reported in two of five cases. No case of BP in the late adolescence was included in the results, as only one case met the search criteria, and overlapped with pemphigus vulgaris. With only 14 cases found in our review, BP in adolescence appears even rarer than in earlier childhood. Despite its low prevalence, BP should be included in the differential diagnosis of autoimmune blistering diseases in adolescents.


Assuntos
Penfigoide Bolhoso/diagnóstico , Adolescente , Anti-Infecciosos/uso terapêutico , Azatioprina/uso terapêutico , Criança , Dapsona/uso terapêutico , Feminino , Glucocorticoides/uso terapêutico , Humanos , Imunossupressores/uso terapêutico , Masculino , Penfigoide Bolhoso/tratamento farmacológico , Prednisona/uso terapêutico
15.
Dermatol Reports ; 10(2): 7859, 2018 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-30370041

RESUMO

Hidradenitis suppurativa (HS) is a relapsing, inflammatory disease characterized by painful nodules, abscesses, sinuses track formation and scarring. HS has a great impact on patients' quality of life and its treatment may be really challenging. Adalimumab provides a new therapeutic option for HS. Our aim was to assess the therapeutic potential of adalimumab on patients with HS based on the data from the daily clinical practice of an HS Outpatient Clinic. 19 patients with clinically evident moderate to severe HS, under adalimumab treatment for at least 24 week, participated in this observational, retrospective study. The Hidradenitis Suppurativa Physician's Global Assessment scale, Modified Santorius scale and Dermatology Life Quality Index (DLQI) at baseline, week 4, week 12 and week 24 were retrieved from the records. Both Modified Santorius score and DLQI were significantly decreased during the weeks of evaluation (Friedman's test; P < 0.001). The proportion of patients who achieved clinical response was 10.5% (n = 2) at week 4, 42.1% (n = 8) at week 12 and 63.2% (n = 12) at week 24. Treatment with adalimumab was linked with both clinical remission of HS and improvement of patients' quality of life.

17.
Dermatology ; 233(5): 378-389, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29232663

RESUMO

BACKGROUND: Psoriasis is an immune-mediated, inflammatory disease. Adipokines contribute to the regulation of immune-mediated processes and inflammation. OBJECTIVE: The aim of our study was to systematically review the literature for studies that have evaluated the circulating concentrations of adipokines in patients with psoriasis and controls and to meta-analyze the best evidence available. METHODS: Eligible were studies that have assessed leptin, resistin, or adiponectin concentrations in psoriatic patients and a reference group. The study was conducted in adherence with the PRISMA standards. RESULTS: Psoriatic patients had higher leptin concentrations compared to controls (random effects model, mean difference, MD = 5.64 ng/mL, 95% CI: 3.00-8.29, p < 0.0001). Heterogeneity among studies was high (I2 = 95.9%). Psoriatic patients had higher resistin concentrations compared to controls (MD = 4.66 ng/mL, 95% CI: 2.62-6.69, p < 0.0001). Heterogeneity was high (I2 = 99.2%). Finally, psoriatic patients had lower adiponectin concentrations compared to controls (MD = -1.87 µg/mL, 95% CI: -2.76 to -0.98, p < 0.0001). Heterogeneity was high (I2 = 95.9%). CONCLUSION: The study supported the hypothesis that leptin and resistin concentrations are higher and adiponectin concentrations are lower in patients with psoriasis compared to controls. Hereby, the suggested pathogenic link between psoriasis and metabolic syndrome/obesity is reinforced and the role of comorbidities in psoriasis is highlighted.


Assuntos
Adiponectina/sangue , Leptina/sangue , Estudos Observacionais como Assunto , Psoríase/sangue , Resistina/sangue , Biomarcadores/sangue , Humanos
18.
Mycoses ; 60(12): 830-835, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28877373

RESUMO

Nail psoriasis and onychomycosis can often be hard to differentiate clinically and may coexist, complicating each other's course. The aim of this study was to determine the prevalence of onychomycosis among patients with nail psoriasis not being treated with immunosuppressive agents, which constitute an independent risk factor for fungal infections. A cross-sectional study was performed. All adult patients with nail psoriasis who were not receiving antifungal and/or immunosuppressive treatment were recruited at the 2nd University Dermatology Department of Aristotle University of Thessaloniki from 10/2016 till 02/2017. If onychomycosis was clinically suspected, nail samples were collected and direct microscopy with 15% KOH solution and culture were performed. Target-NAPSI and DLQI score were also calculated. Of the 23 patients recruited, 20 were men and 3 were women, with a mean age of 53.43 years (48.25, 58.62), a mean target-NAPSI score of 10.72 (9.62, 11.77) and a mean DLQI score of 10.17 (7.46, 12.89). A total of 34.78% of patients tested positive for onychomycosis. Yeast were isolated in 37.50% of cases, non-dermatophyte filamentous fungi in 37.50% and T. rubrum in 12.50%. The prevalence of onychomycosis among nail psoriasis patients is higher than that among the general population of Greece (15%-20%). Yeast and moulds predominate in infection cases of nail psoriasis patients.


Assuntos
Imunossupressores/administração & dosagem , Doenças da Unha/tratamento farmacológico , Psoríase/tratamento farmacológico , Antifúngicos/uso terapêutico , Estudos Transversais , Quimioterapia Combinada , Feminino , Dermatoses do Pé/epidemiologia , Dermatoses do Pé/etiologia , Fungos/classificação , Fungos/efeitos dos fármacos , Fungos/genética , Fungos/isolamento & purificação , Humanos , Masculino , Onicomicose/epidemiologia , Onicomicose/etiologia , Projetos Piloto , Prevalência
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