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1.
Intensive Care Med Exp ; 3(1): 49, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26215813

RESUMO

BACKGROUND: Microcirculation and macrohemodynamics are severely compromised during septic shock. However, the relationship between these two compartments needs to be further investigated. We hypothesized that early resuscitation restores left ventricular (LV) performance and microcirculatory function but fails to prevent metabolic disorders. We studied the effects of an early resuscitation protocol (ERP) on LV pressure/volume loops-derived parameters, sublingual microcirculation, and metabolic alterations during endotoxic shock. METHODS: Twenty-five pigs were randomized into three groups: LPS group: Escherichia coli lipopolysaccharide (LPS); ERP group: LPS + ERP based on volume expansion, dobutamine, and noradrenaline infusion; Sham group. LV pressure/volume-derived parameters, systemic hemodynamics, sublingual microcirculation, and metabolic profile were assessed at baseline and after completing the resuscitation protocol. RESULTS: LPS significantly decreased LV end-diastolic volume, myocardial contractility, stroke work, and cardiac index (CI). Early resuscitation preserved preload, and myocardial contractility, increased CI and heart rate (p < .05). LPS severely diminished sublingual microvascular flow index (MFI), perfused vascular density (PVD), and the proportion of perfused vessels (PPV), while increased the heterogeneity flow index (HFI) (p < .05). Despite MFI was relatively preserved, MVD, PVD, and HFI were significantly impaired after resuscitation (p < .05). The macro- and microcirculatory changes were associated with increased lactic acidosis and mixed venous O2 saturation when compared to baseline values (p < .05). The scatter plot between mean arterial pressure (MAP) and MFI showed a biphasic relationship, suggesting that the values were within the limits of microvascular autoregulation when MAP was above 71 ± 6 mm Hg (R (2) = 0.63). CONCLUSIONS: Early hemodynamic resuscitation was effective to restore macrohemodynamia and myocardial contractility. Despite MAP and MFI were relatively preserved, the persistent microvascular dysfunction could explain metabolic disorders. The relationship between micro- and systemic hemodynamia and their impact on cellular function and metabolism needs to be further studied during endotoxic shock.

2.
Intensive Care Med ; 34(9): 1662-8, 2008 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-18542920

RESUMO

OBJECTIVE: Blood O(2) saturation and lactate concentration gradients from superior vena cava (SVC) to pulmonary artery (PA) occur in critically ill patients. These gradients (DeltaSO(2) and Delta[Lac]) may be positive or negative. We tested the hypothesis that positive DeltaSO(2) and Delta[Lac] are associated with improved survival in critically ill patients. DESIGN AND SETTING: Multinational, prospective observational study conducted in six medical and surgical ICUs. PATIENTS: Consecutive sample of 106 adults requiring insertion of a pulmonary artery catheter (PAC). Average age was 59.5 +/- 15.5 years, APACHE II score was 15.5 +/- 6.7 (mean +/- SD). Main outcome measure was 28-day mortality. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: We drew blood samples from the proximal and distal ports of PACs every 6 h from the time of PAC insertion (Initial measurement) until its removal (Final measurement). Samples were analyzed for SO(2), [Lac], glucose concentration and blood gases. Hemodynamic measurements were obtained after blood samples. We monitored patients for 30.9 +/- 11.0 h. Overall mortality rate was 25.5%. More survivors had mean and final DeltaSO(2) > or = 0 and Delta[Lac] > or = 0 than decedents (p < 0.01; p < 0.05 respectively). On the average, DeltaSO(2) and Delta[Lac] were positive in survivors and negative in decedents. Survival odds ratios for final measurements of DeltaSO(2) > or = 0 and Delta[Lac] > or = 0 were 19.22 and 7.70, respectively (p < 0.05). CONCLUSIONS: A strong association exists between positive DeltaSO(2) and Delta[Lac] and survival in critically ill patients. Whether therapy aimed at increasing DeltaSO(2) and Delta[Lac] results in improved ICU survival remains to be determined.


Assuntos
Estado Terminal/mortalidade , Lactatos/sangue , Oxigênio/sangue , Complicações Pós-Operatórias/sangue , Complicações Pós-Operatórias/mortalidade , Sepse/sangue , Sepse/mortalidade , APACHE , Cateterismo Venoso Central , Estado Terminal/classificação , Feminino , Hemodinâmica , Humanos , Unidades de Terapia Intensiva , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Análise de Sobrevida
3.
RNC ; 12(4): 114-123, oct.-dic. 2003. tab, graf
Artigo em Espanhol | LILACS | ID: lil-383697

RESUMO

Las fístulas digestivas son complicaciones relativamente frecuentes, su manejo es complejo y debe ser realizado por un equipo multiciplinario, en el que la nutrición tiene un rol primordial. Se realizó un estudio retrospectivo de los pacientes con fístulas enterocutáneas y se valoró la influencia del soporte nutricional en el tratamiento de las mismas. El estudio abarcó 93 pacientes que fueron asistidos en la unidad de nutrición y en la unidad de cuidado intensivo. Los pacientes tenían una edad promedio de 62 ± 12 años, el 59 por ciento correspondió al sexo masculino. Según su evolución final fueron considerados curados (N: 63), y no curados que comprendían pacientes fallecidos (N: 23) y dados de alta con fístula (N: 7). La mortalidad global de 24,7 por ciento. La evaluación nutricional de los pacientes incluyó medidas antropométricas, altura, peso inicial y peso usual, la pérdida de peso fue calculada en 11,9 ± 18 por ciento estos valores no fueron significativamente diferentes entre los pacientes curados y no curados...


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Fístula , Fístula Gástrica , Ciências da Nutrição , Pacientes
4.
RNC ; 12(4): 114-123, oct.-dic. 2003. tab, graf
Artigo em Espanhol | BINACIS | ID: bin-4244

RESUMO

Las fístulas digestivas son complicaciones relativamente frecuentes, su manejo es complejo y debe ser realizado por un equipo multiciplinario, en el que la nutrición tiene un rol primordial. Se realizó un estudio retrospectivo de los pacientes con fístulas enterocutáneas y se valoró la influencia del soporte nutricional en el tratamiento de las mismas. El estudio abarcó 93 pacientes que fueron asistidos en la unidad de nutrición y en la unidad de cuidado intensivo. Los pacientes tenían una edad promedio de 62 ± 12 años, el 59 por ciento correspondió al sexo masculino. Según su evolución final fueron considerados curados (N: 63), y no curados que comprendían pacientes fallecidos (N: 23) y dados de alta con fístula (N: 7). La mortalidad global de 24,7 por ciento. La evaluación nutricional de los pacientes incluyó medidas antropométricas, altura, peso inicial y peso usual, la pérdida de peso fue calculada en 11,9 ± 18 por ciento estos valores no fueron significativamente diferentes entre los pacientes curados y no curados...(AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Ciências da Nutrição , Pacientes , Fístula Gástrica , Fístula
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