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1.
Life Sci ; 243: 117273, 2020 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-31926244

RESUMO

Renal cell carcinoma (RCC) is the ninth most prevalent form of malignancy worldwide. The tumor microenvironment significantly affects gene expression in tumor tissues, which subsequently impacts the prognosis of RCC patients. Available datasets such as The Cancer Genome Atlas (TCGA) can be utilized to improve diagnostic methods and search for novel tumor therapeutic targets and prognostic biomarkers. The current study used the ESTIMATE algorithm to explore the immune and stromal components in RCC. Differentially expressed genes (DEGs) were identified by comparing the gene expression patterns in groups with high and low immune/stromal scores. Functional enrichment analysis was conducted and Kaplan-Meier survival curves were plotted to explore the functions of the DEGs in the tumorigenesis, progression, and prognosis of RCC. Our results revealed that immune and stromal scores are associated with specific clinicopathologic variables in RCC. These variables include gender, tumor grade, tumor stage, tumor size, distant metastasis and prognosis. A total of 48 upregulated and 47 downregulated genes were obtained. Functional enrichment analysis demonstrated a correlation between DEGs and the tumor microenvironment, tumor immune response and RCC tumorigenesis. Kaplan-Meier survival curves showed that 43 out of the 48 identified tumor microenvironment related genes are involved in the prognosis of RCC. Three genes, IL10, IGLL5 and POU2AF1, were selected as the hub genes, and their kinase targets were identified as MAPK1 and PPKCA. A positive correlation was obtained between the expression of IL/POU2AF1 and the abundance of six immune cells. Our study provides potential biomarkers for the therapy and prognosis of RCC.

2.
Food Funct ; 10(12): 7818-7827, 2019 Dec 11.
Artigo em Inglês | MEDLINE | ID: mdl-31696193

RESUMO

Human milk provides a range of nutrients and bioactive components, which can support the growth and development of infants. However, human milk composition may change due to geographic and ethnic variation. This study investigated the variation of the Chinese human milk serum proteome based on mothers with different ethnicities living in different parts of China, using TMT labeling combined with Nano-LC Q Exactive HF MS/MS proteomics. In total, 693 proteins were identified and quantified in human milk serum from Yunnan (Han and Bai ethnicity), Gansu (Han and Tibetan ethnicity), Xinjiang (Uygur ethnicity), and Inner Mongolia (Mongolian ethnicity). The biological function distribution of identified proteins and the summed intensity of proteins belonging to each biological function were similar among groups. The five relatively highly abundant milk serum proteins, lactoferrin, serum albumin, polymeric immunoglobulin receptor, macrophage mannose receptor 1, and bile salt-activated lipase were not significantly different among different geographies and ethnicities. On the other hand, we found 34 proteins that did significantly differ with geography and ethnicity. Those significantly different proteins have known strong interaction in inflammation response and regulation of multi-organism processes. Taken together, biological function distribution was similar on both the qualitative and quantitative levels, and proteins with similar abundance are important in providing basic nutrition and protection for infants, whereas the significantly different proteins may be important for the healthy development of infants from different locations and ethnicities.

3.
J Agric Food Chem ; 67(50): 13922-13928, 2019 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-31746600

RESUMO

We compared phospholipids (PLs), PL fatty acid (FA) composition, and milk fat globule size and structure in human milk (n = 120) from mothers of full-term and preterm infants during lactation (colostrum, transition, 1 mo, 2 mo, and 3 mo) and 8 brands of infant formulas. The absolute quantification of PLs was analyzed using 31P NMR spectroscopy. Sphingomyelin was the dominant PLs (35.01 ± 3.31%) in human milk, whereas phosphatidylcholine and phosphatidylethanolamine were the dominant PLs in infant formulas. The PL content in preterm milk increased during lactation, whereas that in term milk remained stable. Saturated FAs (mainly 16:0 and 18:0) were the most abundant (>60%) PL FA in both preterm and term milk and increased throughout lactation. The mean diameter of milk fat globules in infant formulas was much smaller than that found in human milk (200 nm vs 5.63 µm). Significant differences were observed between human milk and infant formulas with regard to PLs, suggesting that more research is needed to mimic the PL profile in infant formulas.


Assuntos
Glicolipídeos/química , Glicoproteínas/química , Fórmulas Infantis/química , Leite Humano/química , Fosfolipídeos/química , Gravidez/metabolismo , Adulto , Feminino , Idade Gestacional , Glicolipídeos/metabolismo , Glicoproteínas/metabolismo , Humanos , Lactente , Lactação , Masculino , Leite Humano/metabolismo , Fosfolipídeos/metabolismo
4.
Wei Sheng Yan Jiu ; 48(2): 226-231, 2019 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-31133099

RESUMO

OBJECTIVE: To investigate the effect of vitamin D supplementation(VD) in early pregnancy on the serum 25-hydroxyvitamin D(25-OH-D) level and the risk of gestational diabetes mellitus(GDM). METHODS: From October to December 2017, a total of 101 pregnant women with high risk factors for GDM were enrolled in the first pregnancy consultation at the nutrition clinic of Haidian Maternal and Child Health Hospital, and were randomly divided into intervention group and control group. The intervention group was supplemented with 700 U VD and 100 mg of calcium at the beginning of pregnancy, and the control group was supplemented with 100 U VD and 100 mg of calcium at the same time, and the intervention time was until delivery. RESULTS: After intervention, the mean serum 25-OH-D level in the intervention group was(92. 08±29. 69) nmol/L, and that in the control group was(69. 99±25. 10) nmol/L. The serum levels of 25-OH-D in the pregnant women, gestational age and cord blood were higher than those in the control group(P<0. 05). The incidence of GDM in the intervention group was 18. 37%, and the incidence rate in the control group was 28. 85%(P>0. 05). Compared with the control group, the OR value of the risk of GDM in the intervention group was 0. 56(95% CI 0. 22-1. 42)( P<0. 05). CONCLUSION: The supplementation of VD in early pregnancy can significantly improve the VD nutrition level of pregnant women, but does not significantly reduce the incidence of GDM.


Assuntos
Diabetes Gestacional/prevenção & controle , Suplementos Nutricionais , Trimestres da Gravidez/sangue , Deficiência de Vitamina D/complicações , Deficiência de Vitamina D/tratamento farmacológico , Vitamina D/administração & dosagem , Vitaminas/administração & dosagem , Criança , Diabetes Gestacional/sangue , Diabetes Gestacional/etiologia , Feminino , Humanos , Estado Nutricional , Gravidez , Gestantes , Vitamina D/sangue , Deficiência de Vitamina D/sangue , Vitaminas/sangue
5.
Wei Sheng Yan Jiu ; 48(3): 413-417, 2019 May.
Artigo em Chinês | MEDLINE | ID: mdl-31133126

RESUMO

OBJECTIVE: To observe the influence of feeding method on early growth rate of infants. METHODS: A retrospective cohort study was conducted with 416 infants born in a community in Beijing from October 2013 to October 2015. Infants fed by breast milk as the sole source of milk food were classed into the breastfeeding group, others were classed into the non-breastfeeding group. The information of physical examination on birth and within 6-month old was collected to analyze the influence of different feeding method on growth rate Z scores of length and body weight within 6-month old infants. RESULTS: When evaluating the effect of feeding patterns on the growth rate at 1 month, there was no significant difference between the two groups at 0-1 months and 0-3 months old body weight and body length growth rate Z score.When evaluating the effect of feeding patterns on the growth rate at 3 month, the results showed, in the 3-6 months old formula powder feeding group(0.60), the weight growth rate Z score of the infant was higher than that of the predominant breastfeeding group(-0.01).The length-growth rate Z score also showed that the formula powder feeding group(0.40) was higher than the predominant breastfeeding group(-0.03).The weight growth rate Z score of 0-6 months old was higher in the formula powder feeding group(0.90) than in the predominant breastfeeding group(0.60).The body length growth rate Z score was higher in the formula powder feeding group(1.00) than in the predominant breastfeeding group(0.70). CONCLUSION: The feeding pattern of infants at 3 months of age will affect their subsequent growth rate. The addition of formula powder may cause the growth rate curve to shift upwards, thereby increasing the risk of overweight and obesity in infants.


Assuntos
Aleitamento Materno , Leite Humano , Pequim , Métodos de Alimentação , Feminino , Humanos , Lactente , Recém-Nascido , Estudos Retrospectivos
6.
Food Funct ; 10(2): 554-564, 2019 Feb 20.
Artigo em Inglês | MEDLINE | ID: mdl-30681124

RESUMO

Breast milk bacteria play an important role in the early development of the gut microbiota and the immune system. Dominant living bacteria of 89 healthy Chinese women from 11 cities in five regions were analysed by broad-range yeast extract, casitone, and fatty acid and de Man, Rogosa, and Sharpe-based culturing coupled with 16S rRNA sequence and quantitative polymerase chain reaction. Principal coordinate analysis showed that human breast milk samples were classified into three groups, driven by Enterococcus (abundance in group 1, 63.13%), Streptococcus (abundance in group 2, 68.16%) and Staphylococcus (abundance in group 3, 55.17%). The microbiota profile was highly region-specific. Samples from the Northwest and North of China showed higher alpha diversity compared to other regions (p < 0.05). Staphylococcus, Streptococcus, and Enterococcus were the dominant genera in all samples. Lactobacillus had a high occurrence in samples from the Northwest and North, dominated by Lactobacillus reuteri and Lactobacillus gasseri. Samples of mothers with a high postpartum body mass index showed more Staphylococcus and less Lactobacillus and Streptococcus. Staphylococcus was negatively correlated with Lactobacillus and Streptococcus. The mode of delivery also affected the composition of microbiota, even after culture. These findings indicate differences between the North and South, provide effective information for collection of samples in which Lactobacillus is the predominant genus, and lower the detection limit for small amounts of bacteria.


Assuntos
Bactérias/isolamento & purificação , Microbiota/genética , Leite Humano/microbiologia , Adulto , Bactérias/genética , China , Demografia , Feminino , Humanos , Reação em Cadeia da Polimerase , RNA Bacteriano/genética , RNA Ribossômico 16S/genética
7.
Nutrients ; 10(9)2018 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-30189612

RESUMO

BACKGROUND: Lactoferrin (Lf) is a multifunctional protein and one of the most abundant proteins in human milk. Various factors may affect its concentration in human milk, such as stage of lactation, ethnicity, and diet. OBJECTIVES: The objectives of the present study were to examine the dynamic change in milk Lf throughout the course of lactation and explore factors associated with milk Lf concentrations in various Chinese populations. METHODS: This investigation was a part of a large cross-sectional study conducted in 11 provinces/autonomous regions/municipalities (Beijing, Gansu, Guangdong, Guangxi, Heilongjiang, Inner Mongolia, Shandong, Shanghai, Xinjiang, Yunnan, and Zhejiang) across China between 2011 and 2013. Lactating women (n = 6481) within 0⁻330 days postpartum were recruited in the original study. A sub-sample of 824 women was randomly selected, and milk Lf concentrations were determined by UPLC/MS. RESULTS: The Lf concentration in milk from women delivering at term was 3.16 g/L, 1.73 g/L and 0.90 g/L for colostrum, transitional milk, and mature milk, respectively. Lf concentrations differed significantly between stages of lactation (colostrum vs. transitional milk, colostrum vs. mature milk, transitional milk vs. mature milk, all p < 0.001). Maternal BMI, age, mode of delivery, parturition, protein intake, and serum albumin concentration were not correlated with milk Lf concentration. However, milk Lf concentrations varied among different geographical regions (Guangdong (1.91 g/L) vs. Heilongjiang (1.44 g/L), p = 0.037; Guangdong (1.91 g/L) vs. Gansu (1.43 g/L), p = 0.041) and ethnicities (Dai (1.80 g/L) vs. Tibetan (0.99 g/L), p = 0.007; Han (1.62 g/L) vs. Tibetan (0.99 g/L), p = 0.002) in China. CONCLUSIONS: The concentration of Lf in human milk changes dynamically throughout lactation. Few maternal characteristics affect the milk Lf concentration, but it varies across different geographical regions and ethnicities in China.


Assuntos
Grupos Étnicos , Lactação/metabolismo , Lactoferrina/metabolismo , Leite Humano/metabolismo , Características de Residência , População Rural , População Urbana , Aleitamento Materno , China , Colostro , Estudos Transversais , Dieta , Feminino , Humanos , Lactação/etnologia , Período Pós-Parto , Gravidez , Nascimento a Termo
8.
J Environ Sci (China) ; 69: 5-11, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29941268

RESUMO

This study was conducted to examine the association of perfluoroalkyl substance (PFAS) exposure with gestational diabetes mellitus (GDM) risk and postpartum fasting blood glucose. We used a 1:2 matched case-control study with 84 GDM subjects and 168 healthy pregnant women from Beijing, China. The maternal blood was collected at 1-2days before delivery, and eight linear isomers and fourteen branched isomers were determined in maternal serum. Logistic regression analyses were performed to evaluate the associations after adjusting for potential confounders. The median of the sum of levels of total PFASs was 4.24ng/mL with a interquartile range (IQR) of 2.82-6.54ng/mL. Although maternal PFAS exposure was not associated with risk of GDM, significant positive associations were observed between evaluated exposure to specific PFAS congeners and increasing blood glucose. The odds ratio (ORs) of the highest category of postpartum fasting blood glucose for perfluoro-1-metylheptylsulfonat (1m-PFOS), perfluoro-3/4-metylheptylsulfonat (3m+4m-PFOS), perfluoro-5-metylheptylsulfonat (5m-PFOS), and perfluorohexane sulfonate (PFHxS) were 2.03 (95% CI: 1.09-3.77), 1.93 (95% CI: 1.04-3.58), 2.48 (95% CI: 1.33-4.65), and 2.26 (95% CI: 1.21-4.21), respectively, suggesting negative effects of maternal exposure to specific PFAS compounds on glucose metabolism.


Assuntos
Diabetes Gestacional/epidemiologia , Poluentes Ambientais/sangue , Fluorcarbonetos/sangue , Exposição Materna/estatística & dados numéricos , Adulto , Ácidos Alcanossulfônicos/sangue , Pequim , Glicemia/metabolismo , Estudos de Casos e Controles , Diabetes Gestacional/sangue , Feminino , Humanos , Período Pós-Parto , Gravidez
9.
Nutrients ; 10(2)2018 Feb 22.
Artigo em Inglês | MEDLINE | ID: mdl-29470415

RESUMO

Appropriate infant and young child feeding could reduce morbidity and mortality and could improve cognitive development of children. However, nationwide data on exclusive breastfeeding and complementary feeding status in China are scarce. The aim of this study was to assess current exclusive breastfeeding and complementary feeding status in China. A national representative survey (Chinese National Nutrition and Health Survey) of children aged under 6 years was done in 2013. Stratified multistage cluster sampling was used to select study participants. World Health Organization (WHO) infant and young child feeding indicators were firstly used to assess exclusive breastfeeding and complementary feeding practice nationwide. In total, 14,458 children aged under two years (0 to <730 days) were studied from 55 counties in 30 provinces in China. The crude exclusive breastfeeding rate under 6 months was 20.7% (908/4381) and the weighted exclusive breastfeeding rate was 18.6%. The crude prevalence of minimum dietary diversity, minimum meal frequency and minimum acceptable diet were 52.5% (5286/10,071), 69.8% (7027/10,071), and 27.4% (2764/10,071) among children aged 6-23 months, respectively. The weighted rate was 53.7%, 69.1%, and 25.1%, respectively. Residential area, household income and maternal education were positively associated with the three complementary feeding indicators. The exclusive breastfeeding rate under 6 months was low and complementary feeding practice was not optimal in China. Residential area, household income and maternal education might be used to target infants and young children to improve complementary feeding practice.


Assuntos
Alimentação Artificial , Aleitamento Materno , Fórmulas Infantis , Fenômenos Fisiológicos da Nutrição do Lactente , Estado Nutricional , Fatores Etários , Desenvolvimento Infantil , China , Estudos Transversais , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Inquéritos Nutricionais , Fatores Socioeconômicos
10.
Wei Sheng Yan Jiu ; 46(3): 404-408, 2017 May.
Artigo em Chinês | MEDLINE | ID: mdl-29903250

RESUMO

OBJECTIVE: To analyze the changing trend of children's malnutrition and anemia rate in Taicang City, Jiangsu Province from 2009 to 2015. METHODS: Data of medical examination on children under 3 was retrived from Electronic Health Care Records in Taicang, Jiangsu, and children's malnutrition and anemia rates were assessed based on WHO children's growth standard in 2006 and anemia diagnosis standard in 2001. The differences of children's malnutrition and anemia rates from 2009 to 2015 were analyzed based on the data. The Mantel-Haenszel Estimation Method was used to standardize themalnutrition rate and the anemia rate. Mantel-Haenszel Chi-square test was used to compare the differences of count data. RESULTS: The average WAZ, HAZ and WHZ scores were 0. 51, 0. 23 and 0. 56, and the average rates of low weight, stunting, wasting, overweight and obesity were 0. 65%, 1. 54%, 0. 56%, 6. 37% and 1. 03%, respectively. The rates of low weight, wasting, overweight and obesity remained stable from 2009 to 2015. The overweight rate increased from 5. 84% in 2009 to 6. 99% in2012, and dropped to 6. 12% in 2015( MH χ~2= 5. 41, P < 0. 05). The boys had a higher malnutrition rate than the girls, and the migrant children had worse conditions in stunting, overweight and obesity than local children. The anemia rate in children under 3 declined from 24. 02% in 2009 to 9. 25% in 2015( Cochran-Armitage Z = 29. 41, P < 0. 05). The boys had a higher anemia rate than the girls, and the local children had a higher anemia rate than the migrant children. CONCLUSION: The growth status of children under 3 in Taicang from 2009 to 2015 is better than the WHO reference standards. The overweight rates increase from 2009 to 2012 and decline from 2012 to 2015. The anemia rate in children decline from 2009 to 2015. This study indicates that controlling the high overweight rate and high anemia rate in young children under 3 are two predominating working directions in Taicang, Jiangsu.


Assuntos
Anemia/epidemiologia , Desnutrição/epidemiologia , Estado Nutricional , Anemia/etnologia , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Desnutrição/etnologia , Sobrepeso , Prevalência
11.
Chemosphere ; 169: 396-402, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27886542

RESUMO

Perfluoroalkyl substances (PFASs), a group of environmental pollutants, persistently exist in the environment. To investigate the associations between PFASs levels in cord serum and birth weight, birth length and ponderal index, we measured PFASs in cord serum samples from 170 infants from Feb. 2012 to Jun. 2012 in Beijing, China. The mean concentrations in cord serum samples for perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA) and perfluoroundecanoic acid (PFUnA) were 1.285 ng/mL, 1.228 ng/mL, 0.230 ng/mL, 0.224 ng/mL, 0.100 ng/mL and 0.085 ng/mL, respectively. First-born children had slightly higher exposure levels of PFHxS (p < 0.001) and PFOA (p = 0.03) than second-born or third-born children. The spearman correlation coefficients with gestation time were individually 0.160 (p = 0.038) for PFHxS and 0.202 (p = 0.008) for PFOA. Both univariate and multivariate linear regression analysis showed that the exposure levels of PFASs had no statistically significant associations with birth weight, birth length or ponderal index in the present population. For male infants, we observed that PFHxS positively correlated with birth length, but the levels of PFUnA were negatively associated with birth length.


Assuntos
Peso ao Nascer , Poluentes Ambientais/sangue , Sangue Fetal/química , Fluorcarbonetos/sangue , Exposição Materna , Ácidos Sulfônicos/sangue , Adulto , Ácidos Alcanossulfônicos/sangue , Pequim , Caprilatos/sangue , Criança , China , Ácidos Decanoicos/sangue , Ácidos Graxos/sangue , Feminino , Humanos , Lactente , Recém-Nascido , Modelos Lineares , Masculino , Gravidez , Inquéritos e Questionários , Tempo
12.
Med Sci Monit ; 22: 3106-12, 2016 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-27584820

RESUMO

BACKGROUND The aim of this study was to provide valid data for a plate-screw fixation model for fractured posterior-anterior columns of the acetabulum. MATERIAL AND METHODS Nineteen cadaveric bony hemi-pelvis specimens were obtained and 50 healthy adults were enrolled. The modified Stoppa approach and computed tomography (CT) imaging were used to collect the measured parameter data of the module. RESULTS The measured parameter data were as follows: OP, 0.96±0.32 cm in females and 0.92±0.16 cm in males (P>0.05); PI, 0.98±0.28 cm in females, and 0.75±0.23 cm in males (P>0.05); ÐÏ´, 59.68°±6.28° in females and 56.75°±3.22° in males (P>0.05); and Ðφ, 41.27°±2.76° in females and 34.31°±2.78° in males (P<0.05). The corresponding CT image data were as follows: PI, 1.08±0.22 cm in females and 0.85±0.27 cm in males (P>0.05); OP, 1.06±0.29 cm in females and 1.12±0.24 cm in males (P>0.05); ÐÏ´, 55.33°±4.00° in females and 55. 50°±3.43° in males (P>0.05); and Ðφ was 39.21°±2.45°in females and 35.58°±2.31°in males (P<0.05). No significant difference with respect to sex and side existed between specimens and healthy adults (P>0.05). CONCLUSIONS The measured parameter data obtained in healthy adults and cadaveric specimens provided an anatomic basis for the designation of the guide module, and thus confirmed the accuracy and safety of screw placement in fractured columns of the acetabulum.


Assuntos
Acetábulo/cirurgia , Fixação Interna de Fraturas/métodos , Fraturas Ósseas/cirurgia , Cirurgia Assistida por Computador/métodos , Acetábulo/diagnóstico por imagem , Acetábulo/lesões , Adulto , Idoso , Placas Ósseas , Parafusos Ósseos , Cadáver , Feminino , Fixação Interna de Fraturas/instrumentação , Fraturas Ósseas/diagnóstico por imagem , Humanos , Processamento de Imagem Assistida por Computador/métodos , Masculino , Pessoa de Meia-Idade , Cirurgia Assistida por Computador/instrumentação , Tomografia Computadorizada por Raios X/métodos
13.
Sci Rep ; 6: 21699, 2016 Feb 22.
Artigo em Inglês | MEDLINE | ID: mdl-26898235

RESUMO

Perfluoroalkyl substances (PFASs) have been detected in wildlife and human samples worldwide. Toxicology research showed that PFASs could interfere with thyroid hormone homeostasis. In this study, eight PFASs, fifteen PFAS precursors and five thyroid hormones were analyzed in 157 paired maternal and cord serum samples collected in Beijing around delivery. Seven PFASs and two precursors were detected in both maternal and cord sera with significant maternal-fetal correlations (r = 0.336 to 0.806, all P < 0.001). The median ratios of major PFASs concentrations in fetal versus maternal serum were from 0.25:1 (perfluorodecanoic acid, PFDA) to 0.65:1 (perfluorooctanoic acid, PFOA). Spearman partial correlation test showed that maternal thyroid stimulating hormone (TSH) was negatively correlated with most maternal PFASs (r = -0.261 to -0.170, all P < 0.05). Maternal triiodothyronin (T3) and free T3 (FT3) showed negative correlations with most fetal PFASs (r = -0.229 to -0.165 for T3; r = -0.293 to -0.169 for FT3, all P < 0.05). Our results suggest prenatal exposure of fetus to PFASs and potential associations between PFASs and thyroid hormone homeostasis in humans.


Assuntos
Poluentes Ambientais/sangue , Fluorcarbonetos/sangue , Troca Materno-Fetal , Efeitos Tardios da Exposição Pré-Natal/sangue , Tireotropina/sangue , Tiroxina/sangue , Tri-Iodotironina/sangue , Adulto , Pequim , Caprilatos/sangue , Ácidos Decanoicos/sangue , Feminino , Sangue Fetal/química , Feto , Humanos , Masculino , Gravidez , Efeitos Tardios da Exposição Pré-Natal/diagnóstico
14.
Wei Sheng Yan Jiu ; 41(2): 209-14, 2012 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-22611927

RESUMO

OBJECTIVE: To establish a infant and young child feeding index (ICFI) in China to comprehensive evaluate the feeding of children aged 6-24 months. METHODS: Based on the feed index concept defined by Ruel and Menon in 2002, and according to the feeding principle by WHO and Chinese dietary guidelines for children aged 0-6 years, the feed index for infants and young children was built and the variables were scored. Then using WAZ, HAZ and WHZ, the correlation between ICFI and Z score for children in urban and rural of three provinces (Sichuan, Hebei and Heilongjiang) was evaluated. RESULTS: The ICFI was constituted by 7 parts: continued breast-eeding, bottle-feeding, dietary diversity for the past 24 h, frequency of feeding solids/semisolids for the past 24 h, food frequency for the past 7d, the supplementary time of the formula milk and other foods. The difference of ICFI score between urban and rural group was significant (P < 0.05). In urban, the ICFI score of children aged 6-8 months was lower than that of children aged 9-24 months. In urban, the negatively correlation between ICFI and WAZ WHZ was significant (P < 0.05). In rural, the negatively correlation between ICFI and WHZ was significant (P < 0.05), while the positively correlation between ICFI and HAZ was significant (P < 0.05). CONCLUSION: ICFI is effective to evaluate the infant feeding in China.


Assuntos
Aleitamento Materno , Alimentos Infantis/normas , Fenômenos Fisiológicos da Nutrição do Lactente , Pré-Escolar , China , Ingestão de Energia , Feminino , Humanos , Lactente , Masculino , Estado Nutricional , População Rural , Inquéritos e Questionários , População Urbana
15.
Wei Sheng Yan Jiu ; 41(2): 220-4, 2012 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-22611929

RESUMO

OBJECTIVE: To improve the unhealthy eating behaviors in 3-5 years old children and enrich the nutrition knowledge of their parents by the multi-channel health education intervention, and evaluate the effects of intervention. METHODS: By random multi-stage cluster sampling, 810 children (3-5 years old) and their parents were selected from Beijing and Shanghai respectively. The period of intervention was 6 months. Questionnaire surveys about children's eating behavior and the knowledge of their parents were conducted before and after the intervention. RESULTS: After the intervention, the proportion of partial eclipse and drinking beverage declined from 44.5% and 70.4% to 35.5% and 31.7% respectively. The proportion of having regular meal time, fixed dining place, eating by oneself, fix quantify diet and concentrating on food elevate from 80.0%, 87.3%, 73.4%, 32.1% and 27.1% to 92.1%, 90.2%, 83.7%, 44.3% and 40.1%. The awareness about nutrition in parents increased and the attitude to the children's eating behaviors improved after the intervention. CONCLUSION: The intervention has some effects on the improvement of the children' s unhealthy eating behaviors and their parents' nutrition knowledge and attitude.


Assuntos
Comportamento Alimentar/psicologia , Conhecimentos, Atitudes e Prática em Saúde , Pais/psicologia , Pré-Escolar , China , Ingestão de Energia/fisiologia , Feminino , Humanos , Masculino , Planejamento de Cardápio , Pais/educação , Amostragem , Inquéritos e Questionários
16.
Zhonghua Yu Fang Yi Xue Za Zhi ; 45(9): 794-7, 2011 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-22177300

RESUMO

OBJECTIVE: To investigate the relationship of pre-pregnancy body weight, gestational weight gain and postpartum weight retention among women in Beijing. METHODS: Using a cohort design, 600 pregnant women who went to district obstetrics and gynecology hospital in Beijing to establish preconception health care card from 5(th) February to 15(th) March 2009 were recruited. A total of 112 subjects (109 with valid data), 20% of that in baseline, were followed up at 6 months after delivery.70 subjects (66 with valid data) were followed up at one year after delivery. Weight, weight changes and postpartum weight retention were measured for low weight (BMI < 18.5 kg/m(2)), normal weight (18.5 kg/m(2) ≤ BMI ≤ 24.0 kg/m(2)) and overweight or obesity (BMI > 24.0 kg/m(2)) group. RESULTS: The pre-pregnancy weight and antenatal weight were (54.8 ± 8.0) and (70.8 ± 9.3) kg respectively. Gestational weight gain was (16.0 ± 7.0) kg. The postpartum weight of 6 and 12 months were (60.5 ± 9.4) and (57.6 ± 8.6) kg respectively. Comparing to pre-pregnancy, postpartum weight retention in 6 months and 12 months were (5.7 ± 4.5) and (2.7 ± 4.5) kg, weight retention rates were (10.6 ± 8.6)% and (5.2 ± 9.3)%. Antenatal weight among low pre-pregnancy weight group, normal weight and overweight and obese women were (62.6 ± 5.7), (69.9 ± 6.6) and (84.2 ± 9.9) kg, and weight at postpartum 12 months among 3 groups were (49.3 ± 3.2), (56.5 ± 6.9) and (70.5 ± 6.0) kg respectively (F = 25.3, P < 0.01); At postpartum 12 months, low pre-pregnancy weight group ((5.6 ± 5.9) kg), overweight and obese women group ((4.7 ± 1.9) kg) postpartum weight retention was significantly higher than that of the normal weight group ((1.8 ± 4.3) kg) (F = 3.82, P < 0.05). CONCLUSION: The pre-pregnancy body weight is a key risk factor in weight gain during pregnancy and postpartum weight retention.


Assuntos
Sobrepeso , Complicações na Gravidez , Ganho de Peso , Adulto , Índice de Massa Corporal , China , Feminino , Humanos , Período Pós-Parto , Gravidez , Fatores de Risco , Adulto Jovem
17.
Wei Sheng Yan Jiu ; 40(5): 591-5, 2011 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-22043709

RESUMO

OBJECTIVE: The study was carried out to analyze serum carotenoids concentration of some Chinese adults by HPLC. METHODS: One hundred and eighty four 30 - 60 year-old adults (84 males and 100 females) from three different communities were recruited in the investigation. The fast blood samples were collected and separated into serum in summer, autumn, winter and spring of the year, respectively. The serum were extracted with organic solvents and analyzed with a HP1100 HPLC for the concentration of beta-carotene, alpha-carotene, beta-cryptoxanthin, lycopene, and lutein/zeaxanthin. RESULTS: The average serum concentration of carotenoids of investigated population in summer, autumn, winter and spring were as followed (inmicromol/L), respectively: beta-carotene, 0.72 +/- 0.20, 0.71 +/- 0.18, 0.70 +/- 0.19 and 0.63 +/- 0.20; alpha-carotene, 0.037 +/- 0.018, 0.039 +/- 0.015, 0.038 +/- 0.017 and 0.030 +/- 0.019; beta-cryptoxanthin, 0.11 +/- 0.03, 0.14 +/- 0.03, 0.13 +/- 0.04 and 0.10 +/- 0.03; lutein + zeaxanthin, 0.61 +/- 0.16, 0.45 +/- 0.09, 0.46 +/- 0.12 and 0.47 +/- 0.14; lycopene, 0.43 +/- 0.26, 0.11 +/- 0.06, 0.07 +/- 0. 04 and 0.07 +/- 0.03. The average serum beta-carotene concentration of total-population was lowest in spring, but the descent did not occurred from urban sub-population. There were significant seasonal changes in average serum concentrations of alpha-carotene, beta-cryptoxanthin, lutein + zeaxanthin, and lycopene from total population. Further more, there was significant difference of serum concentration of every carotenoid between three sub-populations in every season. CONCLUSIONS: The data of serum carotenoid concentration in total 713 blood samples from some Chinese adults were reported here, which would be helpful to understanding the population distribution of carotenoid concentration in China.


Assuntos
Carotenoides/sangue , Adulto , China , Cromatografia Líquida de Alta Pressão , Criptoxantinas , Feminino , Humanos , Licopeno , Masculino , Pessoa de Meia-Idade , População Rural , Estações do Ano , População Urbana , Xantofilas/sangue , beta Caroteno/sangue
18.
J Nutr ; 141(10): 1834-9, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21865562

RESUMO

We recently featured Chinese dietary patterns that were associated with obesity, hyperglycemia, hypertension, and metabolic syndrome. In this study, we examined the association of those dietary patterns and risk of stroke among 26,276 Chinese adults aged ≥45 y by using data from the 2002 China National Nutrition and Health Survey and explored whether those associations were mediated by obesity, hypertension, hyperglycemia, and other cardiovascular risk factors. The traditional southern Chinese dietary pattern, characterized by high intakes of rice and vegetables and moderate intakes in animal foods, was related to the lowest prevalence of stroke. Compared to the traditional southern dietary pattern, the traditional northern Chinese dietary pattern, characterized by high intakes of refined cereal products, potatoes, and salted vegetables, was associated with an elevated risk of stroke [OR = 1.96 (95% CI = 1.48-2.60); P < 0.0001]. Adjustment for conventional cardiovascular risk factors did not appreciably change the association [multivariate adjusted OR = 1.59 (95%CI = 1.16-2.17); P = 0.004]. The Western dietary pattern characterized by high consumption of beef, fruit, eggs, poultry, and seafood is also associated with an elevated risk of stroke [OR = 2.36 (95%CI = 1.82-3.06); P < 0.0001], but the associations became nonsignificant after adjustment for obesity, hypertension, hyperglycemia, and dyslipidemia. In conclusion, we found that the traditional southern dietary pattern was related to low prevalence of stroke and the traditional northern dietary pattern was associated with an increased stroke risk. The Western dietary patterns also association with high risk of stroke, which was largely mediated by obesity, hypertension, hyperglycemia, and dyslipidemia.


Assuntos
Dieta/efeitos adversos , Acidente Vascular Cerebral/etiologia , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Estudos Transversais , Dieta/etnologia , Dislipidemias/fisiopatologia , Feminino , Inquéritos Epidemiológicos , Humanos , Hiperglicemia/fisiopatologia , Hipertensão/fisiopatologia , Masculino , Pessoa de Meia-Idade , Obesidade/fisiopatologia , Prevalência , Fatores de Risco , Acidente Vascular Cerebral/epidemiologia , Acidente Vascular Cerebral/etnologia , Acidente Vascular Cerebral/prevenção & controle
19.
J Hypertens ; 29(6): 1085-92, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21546877

RESUMO

OBJECTIVES: Maternal famine exposure has been associated with higher blood pressure in the offspring. The aim of the present study was to examine the associations of early life exposure to the 1959-1961 Chinese famine with the risk of hypertension in later life, and to examine whether a nutritional 'rich' environment in later life modifies this association. METHODS: We used data of 7874 adults born between 1954 and 1964 from the 2002 China National Nutrition and Health Survey. Excess death rate was used to determine the severity of the famine. RESULTS: In severely affected famine areas, as compared to adults who were not exposed to famine, those exposed during fetal life had a significantly higher SBP [SBP difference 2.2 mmHg, 95% confidence interval (CI) 1.3-3.0, P < 0.0001], DBP (DBP difference 0.9 mmHg, 95% CI 0.3-1.5, P = 0.003) and a marginally higher risk of hypertension (odds ratio 1.88, 95% CI 1.00-3.53, P = 0.05), after adjustment of age, sex, socioeconomic status, lifestyle, dietary factors and family history of hypertension, which was not observed in less severely affected famine areas (P for interaction was 0.08 for SBP, 0.03 for DBP and 0.03 for hypertension). These associations were more pronounced in participants who had a western dietary pattern or who were overweight as adult. CONCLUSION: Our results suggest that fetal famine exposure is associated with higher blood pressure and an increased risk of hypertension in adulthood. These associations are stronger in participants who have a western dietary pattern or who are overweight as adults.


Assuntos
Hipertensão/epidemiologia , Inanição , Adulto , Pressão Sanguínea , Índice de Massa Corporal , Pré-Escolar , China/epidemiologia , Estudos de Coortes , Feminino , Humanos , Hipertensão/fisiopatologia , Lactente , Recém-Nascido , Masculino , Fatores de Risco
20.
Diabetes Care ; 34(4): 1014-8, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21310886

RESUMO

OBJECTIVE: To examine whether exposure to the Chinese famine during fetal life and early childhood is associated with the risks of metabolic syndrome and whether this association is modified by later life environment. RESEARCH DESIGN AND METHODS: We used data of 7,874 adults born between 1954 and 1964 from the 2002 China National Nutrition and Health Survey. Famine exposure groups were defined as nonexposed; fetal exposed; and early childhood, midchildhood, or late childhood exposed. Excess death rate was used to determine the severity of the famine. The ATP III criteria were used for the definition of metabolic syndrome (three or more of the following variables: elevated fasting triglyceride levels, lower HDL cholesterol levels, elevated fasting glucose levels, higher waist circumference, high blood pressure). RESULTS: In severely affected famine areas, adults who were exposed to the famine during fetal life had a higher risk of metabolic syndrome, as compared with nonexposed subjects (odds ratio 3.13 [95% CI 1.24-7.89, P = 0.016]). Similar associations were observed among adults who were exposed to the famine during early childhood, but not for adults exposed to the famine during mid- or late childhood. Participants who were born in severely affected famine areas and had Western dietary habits in adulthood or were overweight in adulthood had a particularly high risk of metabolic syndrome in later life. CONCLUSIONS: Exposure to the Chinese famine during fetal life or infancy is associated with an increased risk of metabolic syndrome in adulthood. These associations are stronger among subjects with a Western dietary pattern or who were overweight in adulthood.


Assuntos
Síndrome Metabólica/epidemiologia , Inanição , Adulto , Grupo com Ancestrais do Continente Asiático , China , Humanos , Razão de Chances , Fatores de Risco
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