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1.
Sultan Qaboos Univ Med J ; 21(3): 394-402, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34522404

RESUMO

Objectives: Disturbed sleep patterns might alter the autonomic tone and lead to various cardiovascular morbidities. This study aimed to determine sleep patterns (quality, duration, efficiency and daytime sleepiness) and explore their association with blood pressure (BP) and heart rate variability (HRV) in apparently healthy, young Saudi females. Methods: This cross-sectional study was conducted in the Department of Physiology, Imam Abdulrahman Bin Faisal University, Saudi Arabia between March 2019 and December 2019. Self-reported Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale questionnaires were used to collect data. In addition, the participants' BP and HRV was measured. Based on the cut-off values of sleep quality, duration, efficiency and daytime sleepiness scores, participants were categorised into groups. HRV and BP were compared between the groups by a t-test/one-way ANOVA. Results: A total of 98 participants were included in this study (response rate: 72.6%). Poor sleep patterns (quality, duration and efficiency) were observed, but no association was found with BP and HRV parameters among groups with different sleep quality, duration and efficiency. Systolic BP was significantly increased in the moderate to severe daytime sleepiness group (P = 0.039). Dozing off as a passenger in a car, in the afternoon and after lunch were negatively correlated with HRV parameters (P <0.05). Conclusion: Sleep quality, duration and efficiency were not found to be statistically significant, but various dozing-off situations were associated with fluctuations in HRV parameters. Daytime sleepiness may augment sympathetic responses in apparently healthy female participants.


Assuntos
Sono , Pressão Sanguínea , Estudos Transversais , Feminino , Frequência Cardíaca , Humanos , Arábia Saudita/epidemiologia
2.
Cureus ; 12(9): e10259, 2020 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-33042697

RESUMO

Background and objective Hepatitis C infection is prevalent in Pakistan. The purpose of this study was to observe the therapeutic effects of conventional interferon in combination with ribavirin among treatment-naive hepatitis C patients. Methods This descriptive cross-sectional study of hepatitis C combination therapy was conducted at our institute after approval. All the patients received treatment with conventional interferon (5-MU three times weekly) and ribavirin (1000mg/day) for four weeks. A follow-up for the rapid virological response (RVR) was done in the fourth week of treatment.  Results The mean age of the patients was 37.43. There was a gradual decrease in RVR with increasing age after four weeks of treatment.  Conclusion The combination therapy showed good RVR in the fourth week among all hepatitis C patients.

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