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1.
Sci Rep ; 8(1): 3968, 2018 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-29507329

RESUMO

The three dimensional inverters were fabricated using novel complementary structure of stacked bottom n-type aluminum-doped zinc oxide (Al:ZnO) thin-film transistor and top p-type nickel oxide (NiO) thin-film transistor. When the inverter operated at the direct voltage (VDD) of 10 V and the input voltage from 0 V to 10 V, the obtained high performances included the output swing of 9.9 V, the high noise margin of 2.7 V, and the low noise margin of 2.2 V. Furthermore, the high performances of unskenwed inverter were demonstrated by using the novel complementary structure of the stacked n-type Al:ZnO thin-film transistor and p-type nickel oxide (NiO) thin-film transistor.

2.
Biomed Microdevices ; 18(5): 79, 2016 10.
Artigo em Inglês | MEDLINE | ID: mdl-27530346

RESUMO

This article describes a high-efficiency light-induced dielectrophoresis biochip containing a thin film prepared through inductively coupled plasma chemical vapor deposition (ICPCVD). The biochip comprises two ITO glass substrates and a photoconductive amorphous silicon thin film. The biochip can effectively sort particular particles (or cells) by projecting visible light onto the surface of the silicon thin film. The sorting efficiency of biochips is highly associated with the quality of the deposited amorphous silicon thin films; therefore, the choice of deposition technique is extremely critical. However, no study has examined this problem. Hence, the current study thoroughly compared the efficiency of the biochip when films produced through plasma-enhanced chemical vapor deposition and ICPCVD are used.


Assuntos
Eletroforese/instrumentação , Dispositivos Lab-On-A-Chip , Luz , Gases em Plasma/química , Impedância Elétrica , Volatilização
3.
Opt Express ; 23(24): 31150-62, 2015 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-26698744

RESUMO

The combination of ZnO, InN, and GaN epitaxial layers is explored to provide long wavelength photodetection capability in the GaN based materials. Growth temperature optimization was performed to obtain the best quality of InN epitaxial layer in the MOCVD system. The temperature dependent photoluminescence (PL) can provide the information about thermal quenching in the InN PL transitions and at least two non-radiative processes can be observed. X-ray diffraction and energy dispersive spectroscopy are applied to confirm the inclusion of indium and the formation of InN layer. The band alignment of such system shows a typical double heterojunction, which is preferred in optoelectronic device operation. The photodetector manufactured by this ZnO/GaN/InN layer can exhibit extended long-wavelength quantum efficiency, as high as 3.55%, and very strong photocurrent response under solar simulator illumination.

4.
Biosens Bioelectron ; 61: 417-21, 2014 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-24934741

RESUMO

This paper presents a 40-GHz RF biosensor that involves using a microwave coplanar waveguide (CPW) transmission line for the dielectric characterization of cancer cells (Hepatoma G2, HepG2). In the past, conventional resonator-based biosensors were designed to operate at a specific resonant peak; however, the dielectric sensitivity of the cells was restricted to a narrow bandwidth. To provide a very wide bandwidth (1-40 GHz), biosensors were based on a microwave CPW transmission line. The proposed biosensor can rapidly measure two frequency-dependent cell-based dielectric parameters of HepG2 cells, microwave attenuation (α(f)cell) and the dielectric constant (εr(f)cell), while removing the microwave parasitic effects (including the cultured medium and substrate materials). The proposed biosensor can be applied in postoperative cancer diagnosis.


Assuntos
Técnicas Biossensoriais/instrumentação , Células Hep G2/patologia , Proliferação de Células , Eletricidade , Desenho de Equipamento , Células Hep G2/citologia , Humanos , Neoplasias Hepáticas/diagnóstico , Micro-Ondas
5.
Nanoscale Res Lett ; 9(1): 242, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24948884

RESUMO

The simple self-aligned photolithography technique and laser interference photolithography technique were proposed and utilized to fabricate multiple-gate ZnO metal-oxide-semiconductor field-effect transistors (MOSFETs). Since the multiple-gate structure could improve the electrical field distribution along the ZnO channel, the performance of the ZnO MOSFETs could be enhanced. The performance of the multiple-gate ZnO MOSFETs was better than that of the conventional single-gate ZnO MOSFETs. The higher the drain-source saturation current (12.41 mA/mm), the higher the transconductance (5.35 mS/mm) and the lower the anomalous off-current (5.7 µA/mm) for the multiple-gate ZnO MOSFETs were obtained.

6.
J Nanosci Nanotechnol ; 14(5): 3988-92, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24734678

RESUMO

With CO2 laser assistance, crystalline Ge nanocluster-embedded Ge films were deposited at low temperature using a conventional plasma-enhanced chemical vapor deposition system. Raman spectrum showed a wavenumber peak at 290 cm(-1) which corresponded to the crystalline Ge nanoclusters in the Ge film deposited with CO2 laser assistance. Crystalline Ge nanoclusters embedded in Ge matrices were observed from transmission electron microscopy (TEM) images and electron diffraction pattern. The electroluminescent devices constructed with multilayered Ge nanoclusters-embedded Ge films were fabricated. The experimental results demonstrated that the electroluminescence emission originated from the radiative recombination of the electron-hole pairs in the Ge nanoclusters.

7.
Opt Express ; 21(21): 24599-610, 2013 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-24150304

RESUMO

This study evaluates the effect of crystallinity and point defects on time-dependent photoresponsivity and the cathodoluminescence (CL) properties of ß-Ga2O3 epilayers. A synchrotron high-resolution X-ray technique was used to understand the crystalline structure of samples. Rutherford backscattering spectroscopy was used to determine the net chemical composition of the samples to examine the type and ratio of their possible point defects. The results show that in functional time-dependent photoresponsivity of photodetectors based on ß-Ga2O3 epilayers, point defects contribution overcomes the contribution of crystallinity. However, the crystalline structure affects the intensities and emission regions of CL spectra more than point defects.

8.
J Biochem ; 149(6): 685-92, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21288888

RESUMO

Fibroblast activation protein (FAP) is a prolyl-cleaving endopeptidase proposed as an anti-cancer drug target. It is necessary to define its cleavage-site specificity to facilitate the identification of its in vivo substrates and to understand its biological functions. We found that the previously identified substrate of FAP, α(2)-anti-plasmin, is not a robust substrate in vitro. Instead, an intracellular protein, SPRY2, is cleavable by FAP and more suitable for investigation of its substrate specificity in the context of the full-length globular protein. FAP prefers uncharged residues, including small or bulky hydrophobic amino acids, but not charged amino acids, especially acidic residue at P1', P3 and P4 sites. Molecular modelling analysis shows that the substrate-binding site of FAP is surrounded by multiple tyrosine residues and some negatively charged residues, which may exert least preference for substrates with acidic residues. This provides an explanation why FAP cannot cleave interleukins, which have a glutamate at either P4 or P2', despite their P3-P2-P1 sites being identical to SPRY2 or α-AP. Our study provided new information on FAP cleavage-site specificity, which differs from the data obtained by profiling with a peptide library or with the denatured protein, gelatin, as the substrate. Furthermore, our study suggests that negatively charged residues should be avoided when designing FAP inhibitors.


Assuntos
Gelatinases/metabolismo , Peptídeos e Proteínas de Sinalização Intracelular/metabolismo , Proteínas de Membrana/metabolismo , Serina Endopeptidases/metabolismo , Células Cultivadas , Gelatinases/química , Gelatinases/isolamento & purificação , Humanos , Peptídeos e Proteínas de Sinalização Intracelular/química , Proteínas de Membrana/química , Proteínas de Membrana/isolamento & purificação , Modelos Moleculares , Proteínas Recombinantes/química , Proteínas Recombinantes/isolamento & purificação , Proteínas Recombinantes/metabolismo , Serina Endopeptidases/química , Serina Endopeptidases/isolamento & purificação , Especificidade por Substrato
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