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1.
Rev. bras. med. esporte ; 25(4): 299-304, July-Aug. 2019. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-1013654

RESUMO

ABSTRACT Objective: To compare maximal fat oxidation rates (FATMAX) and analyze their association with cardiorespiratory fitness in adolescents with type 1 diabetes mellitus (T1DM). Methods: Twenty-two male and female adolescents aged between 11 to 17 years, following clinical and anthropometric evaluations, were assigned to the diabetic group (DG; n = 10) or control group (CG; n = 12). Cardiorespiratory fitness was determined by maximal oxygen uptake (VO2max) during a maximal aerobic test on a cycle ergometer using the Balke protocol. Maximal fat oxidation (FATMAX) was determined by the respiratory exchange ratio proposed in the Lusk table. Results: Adolescents in the DG had lower mean FATMAX (p<0.01) and %VO2FATMAX (p=0.001) values when compared with those in the CG. FATMAX values were inversely correlated with serum glycosylated hemoglobin (HbA1c) levels (r= −0.77) and directly correlated with BMI z-scores (r=0.76), while %VO2FATMAX results were correlated with age (r=0.81), BMI z-scores (r=0.65), and VO2max values (r=0.81). On multiple linear regression, HbA1c values explained 54% (adjusted r²=0.54, p=0.009) and BMI z-scores explained 3.1% (adjusted r²=-0.031, p=0.009) of the variation in FATMAX in the DG. Adolescents with T1DM had similar cardiorespiratory fitness and lower FATMAX rates (35±11 VO2max) when compared with controls (60±12 VO2max). Conclusion: These results suggest lower fat oxidation rates and greater use of glucose as an energy substrate during exercise and worse control in T1DM. Therefore, results may contribute to appropriate exercise prescription in T1DM, after verifying exercise intensity to reduce hypoglycemia risk. Level of evidence III; Case-control study.


RESUMO Objetivo: Comparar as taxas máximas de oxidação da gordura (FATMAX) e analisar a sua associação com a aptidão cardiorrespiratória em adolescentes com diabetes mellitus tipo 1 (DM1). Métodos: Vinte e dois adolescentes de ambos os sexos, de 11 a 17 anos, após avaliações clínicas e antropométricas, foram alocados no grupo diabético (GD; n = 10) ou no grupo controle (GC; n = 12). A aptidão cardiorrespiratória foi determinada pelo consumo máximo de oxigênio (VO2max) durante um teste aeróbico máximo em um cicloergômetro utilizando o protocolo Balke. A oxidação máxima da gordura (FATMAX) foi determinada pela razão de troca ventilatória proposta na Tabela de Lusk. Resultados: Os adolescentes no GD apresentaram menores valores médios de FATMAX (p<0,01) e % VO2FATMAX (p=0,001) quando comparados com aqueles no GC. Os valores de FATMAX correlacionaram-se inversamente com os níveis de hemoglobina glicosilada sérica (HbA1c) (r = −0,77) e diretamente com o z-score IMC (r = 0,76), enquanto os resultados de %VO2FATMAX correlacionaram-se diretamente com a idade (r = 0,81), z-score IMC (r = 0,65) e VO2max (r = 0,81). Na regressão linear múltipla, os valores de HbA1c explicaram 54% (r² ajustado = 0,54, p = 0,009) e o z-score IMC explicou 3,1% (r² ajustado = −0,031, p = 0,009) da variação no FATMAX no GD. Os adolescentes com DM1 apresentaram aptidão cardiorespiratória similar e taxas de FATMAX menores (35±11 VO2max) quando comparados com os do grupo controle (60±12 VO2max). Conclusão: Esses resultados sugerem taxas menores de oxidação da gordura e maior uso da glicose como substrato de energia durante o exercício e pior controle no DM1. Portanto, os resultados podem contribuir com a prescrição de exercício apropriada no DM1, após verificar a intensidade do exercício, a fim de diminuir o risco de hipoglicemia. Nível de evidência III; Estudo de caso-controle.


RESUMEN Objetivo: Comparar las tasas máximas de oxidación de la grasa (FATMAX) y analizar su asociación con la aptitud cardiorrespiratoria en adolescentes con diabetes mellitus tipo 1 (DM1). Métodos: Veintidós adolescentes de ambos sexos, de 11 a 17 años, después de evaluaciones clínicas y antropométricas, fueron asignados en el grupo diabético (GD, n = 10) o en el grupo control (GC, n = 12). La aptitud cardiorrespiratoria fue determinada por el consumo máximo de oxígeno (VO2max) durante un test aeróbico máximo en un cicloergómetro utilizando el protocolo Balke. La oxidación máxima de la grasa (FATMAX) fue determinada por la razón de cambio ventilatorio propuesta en la Tabla de Lusk. Resultados: Los adolescentes en el GD presentaron menores valores promedio de FATMAX (p<0,01) y % VO2FATMAX (p=0,001) cuando comparados con aquellos en el GC. Los valores de FATMAX se correlacionaron inversamente con los niveles de hemoglobina glicosilada sérica (HbA1c) (r = −0,77) y directamente con el z-score IMC (r = 0,76), mientras que los resultados de %VO2FATMAX se correlacionaron directamente con la edad (r = 0,81), z-score IMC (r = 0,65) y VO2max (r = 0,81). En la regresión lineal múltiple, los valores de HbA1c explicaron 54% (r² ajustado = 0,54, p = 0,009) y el z-score IMC explicó 3,1% (r² ajustado = −0,031, p = 0,009) de la variación en el FATMAX en el GD. Los adolescentes con DM1 presentaron aptitud cardiorrespiratoria similar y tasas de FATMAX menores (35±11 VO2max) cuando comparados con los del grupo control (60±12 VO2max). Conclusión: Esos resultados sugieren tasas menores de oxidación de la grasa y mayor uso de la glucosa como substrato de energía durante el ejercicio y peor control en la DM1. Por lo tanto, los resultados pueden contribuir con la prescripción de ejercicio apropiada en la DM1, después de verificar la intensidad del ejercicio, a fin de disminuir el riesgo de hipoglucemia. Nivel de evidencia III; Estudio de caso-control.

2.
Rev. bras. med. esporte ; 25(4): 322-327, July-Aug. 2019. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-1013656

RESUMO

ABSTRACT Introduction: Studies of association between obesity and genetic factors have demonstrated a significant contribution of polymorphisms related to body fat distribution and subclinical inflammatory process. Objective: To investigate the association between genotypes of the Gln27Glu polymorphism of the ADRB2 gene and indicators of adiposity, inflammatory markers, metabolic parameters and parameters of physical fitness in overweight adolescents. Methods: A total of 44 male and female adolescents, aged between 13 and 17 years, with positive clinical diagnosis of overweight, were divided into two groups according to the Gln27Glu polymorphism genotypes of the ADRB2 gene: a) Group of carriers of the 27Glu allele (Gln27Glu/Glu27Glu) (n = 22); b) Group of non-carriers of the 27Glu allele (Gln27Gln) (n = 22). Both groups were evaluated for body composition, sexual maturation, cardiorespiratory fitness variables and indicators of muscle strength. Basal glycemia and insulin, lipid profile and inflammatory profile were measured. Abdominal subcutaneous and visceral adiposities were evaluated by ultrasonography. Genotyping of the Gln27Glu polymorphism of the ADRB2 gene was performed by the Taqman allelic discrimination assay. Results: The genotype frequency found was: Gln/Gln (n = 22) (50.0%), Gln/Glu (n = 18) (41.0%) and Glu/Glu (n = 4) %). The frequency of the 27Glu allele was 29.5%. The group of adolescent carriers of the 27Glu allele of the ADRB2 gene presented higher mean adiposity indicators (abdominal circumference, trunk fat mass and visceral fat), as well as lower IL-10 concentrations when compared to non-carriers. Conclusions: The 27Glu allele was associated with adiposity indicators in overweight adolescents, while subcutaneous abdominal fat exhibited an inverse relationship with inflammatory variables and maximum oxygen uptake, which may result in more damage to health. Level of evidence III; Case-control study.


RESUMO Introdução: Estudos de associação entre a obesidade e fatores genéticos têm demonstrado a significativa contribuição de polimorfismos relacionados à distribuição de gordura corporal e processo inflamatório subclínico. Objetivo: Investigar a associação entre os genótipos do polimorfismo Gln27Glu do gene ADRB2 e indicadores de adiposidade, marcadores inflamatórios, parâmetros metabólicos e de aptidão física em adolescentes com excesso de peso. Métodos: Participaram 44 adolescentes, de ambos os sexos, com idade entre 13 e 17 anos, com diagnóstico clínico positivo de excesso de peso, divididos em dois grupos conforme os genótipos do polimorfismo Gln27Glu do gene ADRB2: a) Grupo de portadores do alelo 27Glu (Gln27Glu/Glu27Glu) (n=22); b) Grupo de não portadores do alelo 27Glu (Gln27Gln) (n=22). Ambos os grupos foram avaliados quanto à composição corporal, maturação sexual, variáveis de aptidão cardiorrespiratória e indicadores de força muscular. Foram dosados glicemia e insulina basais, perfil lipídico e perfil inflamatório. As adiposidades abdominais subcutânea e visceral foram avaliadas através de ultrassonografia. A genotipagem do polimorfismo Gln27Glu do gene ADRB2 foi realizada através do ensaio de discriminação alélica Taqman. Resultados: A frequência genotípica encontrada foi: Gln/Gln (n=22) (50,0%), Gln/Glu (n=18) (41,0%) e Glu/Glu (n=4) (9,0%). A frequência do alelo do 27Glu foi de 29,5%. O grupo de adolescentes portadores do alelo 27Glu do gene ADRB2 apresentou maiores médias de indicadores de adiposidade (circunferência abdominal, massa gorda troncular e gordura visceral), assim como menores concentrações de IL-10 quando comparados aos não portadores. Conclusões: O alelo 27Glu apresentou associação com os indicadores de adiposidade em adolescentes com excesso de peso, assim como a gordura abdominal subcutânea demonstrou relação inversa com as variáveis inflamatórias e o consumo máximo de oxigênio, podendo resultar em maiores prejuízos à saúde. Nível de evidência III; Estudo de caso-controle.


RESUMEN Introducción: Estudios de asociación entre la obesidad y factores genéticos han demostrado la significativa contribución de polimorfismos relacionados a la distribución de grasa corporal y proceso inflamatorio subclínico. Objetivo: Investigar la asociación entre los genotipos del polimorfismo Gln27Glu del gen ADRB2 e indicadores de adiposidad, marcadores inflamatorios, parámetros metabólicos y de aptitud física en adolescentes con exceso de peso. Métodos: Participaron 44 adolescentes, de ambos sexos, con edad entre 13 y 17 años, con diagnóstico clínico positivo de exceso de peso, divididos en dos grupos según los genotipos del polimorfismo Gln27Glu del gen ADRB2: a) Grupo de portadores del alelo 27Glu (Gln27Glu/Glu27Glu) (n = 22); b) Grupo de no portadores del alelo 27Glu (Gln27Gln) (n = 22). Ambos grupos fueron evaluados cuanto a la composición corporal, madurez sexual, variables de aptitud cardiorrespiratoria e indicadores de fuerza muscular. Fueron dosificadas glucemia e insulina basales, perfil lipídico y perfil inflamatorio. Las adiposidades abdominales subcutánea y visceral fueron evaluadas a través de ultrasonografía. El genotipado del polimorfismo Gln27Glu del gen ADRB2 fue realizado a través del ensayo de discriminación alélica Taqman. Resultados: La frecuencia genotípica encontrada fue: Gln/Gln (n = 22) (50,0%), Gln/Glu (n = 18) (41,0%) y Glu/Glu (n = 4) (9,0%). La frecuencia del alelo del 27Glu fue del 29,5%. El grupo de adolescentes portadores del alelo 27Glu del gen ADRB2 presentó mayores promedios de indicadores de adiposidad (circunferencia abdominal, masa grasa troncular y grasa visceral), así como menores concentraciones de IL-10, en comparación con los no portadores. Conclusiones: El alelo 27Glu presentó asociación con los indicadores de adiposidad en adolescentes con exceso de peso, así como la grasa abdominal subcutánea demostró relación inversa con las variables inflamatorias y el consumo máximo de oxígeno, lo que puede resultar en mayores perjuicios a la salud. Nivel de Evidencia III; Estudio de caso-control.

3.
Braz J Phys Ther ; 2019 Apr 20.
Artigo em Inglês | MEDLINE | ID: mdl-31047776

RESUMO

BACKGROUND: The combination of interval training and resistance training has showed interesting results in chronic heart failure patients, corroborating the benefits of physiological adaptations of both protocols. OBJECTIVE: To evaluate the effect of the combination of interval training and resistance training program when compared to interval training alone and/or without intervention group on cardiorespiratory fitness in patients with chronic heart failure. METHODS: We search MEDLINE via PubMed, ScienceDirect, Sportdiscus, BIREME and Scielo, from their inception to December 2018. Were included both randomized and non-randomized controlled trials comparing the effect of combined training, interval training alone and/or WI group on VO2peak (expressed in ml/kg/min), in people with chronic heart failure patients. The meta-analysis was conducted via Review Manager v 5.3 software, using random effect model. RESULTS: Ten articles were selected (nine randomized controlled trial), involving 401 participants. Six studies compared combined training with interval training and six studies compared combined training with the without intervention group. Eighty percent of the trials presented moderate risk of bias and twenty percent low risk of bias. Data showed significant difference and major increase in VO2peak in favor to combined training group compared to interval training group (SMD=0.25; CI=0.04-0.46) and without intervention group (SMD=0.46; CI=0.29-0.64), respectively. CONCLUSION: The combination of interval training and resistance training showed more effective in increasing cardiorespiratory fitness in patients with heart failure than interval training alone and non-exercise therapy. However, further studies should be conducted to increase the understanding of this combined training method.

4.
Rev. Paul. Pediatr. (Ed. Port., Online) ; 37(2): 241-251, Apr.-June 2019. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-1013287

RESUMO

ABSTRACT Objective: To systematically review the literature as for the level of evidence of predictive equations of VO2peak through the 20-meter shuttle run test (20m-SRT) in children and adolescents. Data sources: Searches were conducted independently by two researchers, according to the procedures adopted by PRISMA, in the electronic databases MEDLINE via PubMed, ScienceDirect, Web of Science, LILACS and SciELO, for articles published until September 2017 in English and Portuguese. The inclusion criteria were: original studies, abstract available, using predictive equations of VO2peak through 20m-SRT, conducted with adolescents and/or children, non-athletes, and mentioning correlation analysis between predicted and measured VO2peak. The level of evidence of equations was based on the risk of bias of the studies using the following criteria: sample number, sample characteristics, and statistical analysis. Data synthesis: Eighteen studies were selected, in which fifteen equations were found and analyzed. The studies had been conducted with samples composed of subjects of both sexes, aged 8 to 19 years. Equations of Léger and Matsuzaka had their level of evidence classified as high, and estimation ranged between r=0.54-0.90 and r=0.65-0.90. Equations by Ruiz, Barnett and Matsuzaka had their level of evidence classified as moderate, and estimation ranged between r=0.75-0.96, r=0.66-0.84 and r=0.66-0.89, respectively. Conclusions: Matsuzaka's equation presented satisfactory parameters for estimates of VO2peak in children and adolescents. Although not explored in equations, body adiposity and pubertal stage are significantly associated with cardiorespiratory fitness in children and adolescents.


RESUMO Objetivo: Revisar sistematicamente na literatura o nível de evidência das equações preditivas do pico de consumo de oxigênio (VO2pico) por meio do teste de shuttle run de 20 metros (SR-20m) em crianças e adolescentes. Fonte de dados: As buscas foram conduzidas nas bases de dados eletrônicas Medical Literature Analysis and Retrieval System Online (MEDLINE) via PubMed, ScienceDirect, Web of Science, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Scientific Electronic Library Online (SciELO), de agosto a setembro de 2017, nos idiomas inglês e português. Os critérios de inclusão utilizados foram: estudos originais, com resumo disponível, com equações para predição do VO2pico por meio do SR-20m, adolescentes e/ou crianças, não atletas e com análise correlacional do VO2pico predito e mensurado. O nível de evidência das equações foi caracterizado com base no risco de viés dos estudos, no qual se adotou os seguintes critérios: número da amostra, características da amostra e análise estatística. Síntese dos dados: Dezoito estudos foram selecionados, nos quais 12 equações foram encontradas e analisadas. Os estudos foram conduzidos com amostras de ambos os sexos com idades de oito a 19 anos. As equações de Léger e Matsuzaka foram classificadas com forte nível de evidência, com variação de amplitude de estimativa entre r=0,54-0,90 e r=0,65-0,90. Enquanto as equações Ruiz, Barnett e Matsuzaka foram consideradas de evidência moderada, com variação de amplitude de estimativa entre r=0,75-0,96, r=0,66-0,84 e r=0,66-0,89, respectivamente. Conclusões: A equação de Matsuzaka apresentou parâmetros satisfatórios para estimar o VO2pico em crianças e adolescentes. Embora não explorados em equações, a adiposidade corporal e o estágio puberal demonstram associações relevantes com a aptidão cardiorrespiratória em crianças e adolescentes.

5.
J Pediatr Endocrinol Metab ; 32(3): 239-246, 2019 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-30844760

RESUMO

Background Cardiorespiratory fitness (CRF) and pubertal stages have been related to many health outcomes, including obesity and adipocytokines. Thus, the present study aimed to analyze the moderator role of CRF and pubertal stage in the relationship between adiposity and adipocytokines in girls. Method This cross-sectional study was performed with 42 pre-pubertal girls aged from 7 to 11 years and 54 post-pubertal girls aged from 13 to 17 years. Blood samples were collected to determine the serum levels of leptin and adiponectin, and then the leptin/adiponectin ratio (L/A ratio) was calculated. CRF, anthropometric and body composition indicators were assessed. For statistical analysis, descriptive statistics and several linear regression models were used. The moderation analysis was tested using the PROCESS macro. Results An interaction between body mass index (BMI) and CRF (ß: -0.70; confidence interval [CI]: -1.29, -0.12), as well as between BMI and pubertal stage (ß: 0.79; CI: 0.28, 1.30) with leptin, was found. Regarding the L/A ratio, an interaction was found only in BMI × CRF (ß: -0.56; CI: -1.06, -0.06). Using a combined interaction (CRF and pubertal stage), the results showed a positive association between BMI with leptin and L/A ratio only in low CRF, pre-pubertal and post-pubertal stages. Conclusion This study suggests a protective role of high levels of CRF in the relationship between BMI and adipocytokines. Despite the effect of pubertal stage, the results suggest that youth should be engaged in physical activity in order to improve CRF levels and consequently improve cardiometabolic health.


Assuntos
Adiponectina/sangue , Adiposidade/fisiologia , Aptidão Cardiorrespiratória/fisiologia , Exercício/fisiologia , Leptina/sangue , Puberdade/fisiologia , Adolescente , Composição Corporal/fisiologia , Índice de Massa Corporal , Criança , Estudos Transversais , Feminino , Humanos , Puberdade/sangue
6.
Rev Paul Pediatr ; 37(2): 241-251, 2019.
Artigo em Inglês, Português | MEDLINE | ID: mdl-30892544

RESUMO

OBJECTIVE: To systematically review the literature as for the level of evidence of predictive equations of VO2peak through the 20-meter shuttle run test (20m-SRT) in children and adolescents. DATA SOURCES: Searches were conducted independently by two researchers, according to the procedures adopted by PRISMA, in the electronic databases MEDLINE via PubMed, ScienceDirect, Web of Science, LILACS and SciELO, for articles published until September 2017 in English and Portuguese. The inclusion criteria were: original studies, abstract available, using predictive equations of VO2peak through 20m-SRT, conducted with adolescents and/or children, non-athletes, and mentioning correlation analysis between predicted and measured VO2peak. The level of evidence of equations was based on the risk of bias of the studies using the following criteria: sample number, sample characteristics, and statistical analysis. DATA SYNTHESIS: Eighteen studies were selected, in which fifteen equations were found and analyzed. The studies had been conducted with samples composed of subjects of both sexes, aged 8 to 19 years. Equations of Léger and Matsuzaka had their level of evidence classified as high, and estimation ranged between r=0.54-0.90 and r=0.65-0.90. Equations by Ruiz, Barnett and Matsuzaka had their level of evidence classified as moderate, and estimation ranged between r=0.75-0.96, r=0.66-0.84 and r=0.66-0.89, respectively. CONCLUSIONS: Matsuzaka's equation presented satisfactory parameters for estimates of VO2peak in children and adolescents. Although not explored in equations, body adiposity and pubertal stage are significantly associated with cardiorespiratory fitness in children and adolescents.

7.
Rev. bras. cineantropom. desempenho hum ; 21: e55915, 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1013433

RESUMO

ABSTRACT The aim of the present study was to verify the level of concordance between Body Adiposity Index (BAI) and Dual-energy X-ray Absorptiometry (DEXA) in the evaluation of body fat percentage in adolescents with type-1 diabetes mellitus (DM1). The sample consisted of 34 adolescents (16 boys and 18 girls) aged 10-15 years. Height and hip circumference data were collected for BAI calculation, and fat percentage was evaluated using DEXA. The Shapiro Wilk test was used to verify data normality. The Wilcoxon test was performed to compare age, anthropometric and BMI, BAI z score and DEXA between sexes. The correlation of variables (BAI vs DEXA) was evaluated by the Spearman correlation coefficient. For the analysis of residual scores, the Bland-Altman test was applied. The Kappa coefficient (k) was performed to assess the level of concordance between BAI and DEXA. Therefore, weak and non-significant correlation between BAI and DEXA in boys (r= 0.19, p= 0.46), and girls (r= 0.10, p= 0.73) was observed. Thus, weak concordance was observed (k= 0.09) for both sexes. It was concluded that BAI is not recommended to estimate fat percentage in adolescents with DM1.


Resumo O objetivo do presente estudo foi verificar o nível de concordância entre o Absortometria de Raio-x de Dupla Energia (DEXA) na avaliação do percentual de gordura de adolescentes com diabetes mellitus tipo 1 (DM1). A amostra foi constituída por 34 adolescentes (16 meninos e 18 meninas) com idades entre 10 e 15 anos. Coletaram-se os dados de estatura e circunferência do quadril para cálculo do IAC, bem como avaliação do percentual de gordura via DEXA. O teste de Shapiro Wilk foi utilizado para verificar a normalidade dos dados. O teste de Wilcoxon foi realizado para comparar as variáveis de idade, antropométricas e IMC score Z, IAC e DEXA entre sexos. A correlação das variáveis (IAC vs DEXA) foi avaliada pelo coeficiente de correlação de Spearman. Para análise dos escores residuais aplicou-se o teste de Bland-Altman. O coeficiente de Kappa (k) foi realizado para avaliar o nível de concordância entre o IAC e DEXA. Sendo assim, foi encontrada correlação fraca e não significante entre IAC e DEXA tanto nos meninos (r=0,19; p=0,46), quanto nas meninas (r=0,10; p=0,73). Dessa forma, foi possível perceber concordância fraca (k= 0,09) para ambos os sexos. Conclui-se que o IAC não é recomendado para estimar percentual de gordura em adolescentes com DM1.


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Distribuição da Gordura Corporal , Absorciometria de Fóton , Antropometria , Diabetes Mellitus
8.
Genet Mol Biol ; 2018 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-30507998

RESUMO

Genes can influence lipid profile and anthropometric variables related to obesity. The present study aimed to verify if variants of the APOE, APOB, ADIPOQ, HSD11ß1, and PLIN4 genes are associated with lipid levels or anthropometric variables in a sample comprised of 393 Euro-Brazilian children and adolescents. DNA was genotyped by TaqMan allelic discrimination assay. The ε4 and ε2 alleles of the APOE gene were associated respectively with lower high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels (p=0.015 and p=0.012, respectively), while the ε3 allele was associated with higher abdominal circumference (p=0.0416) and excess weight (p=0.0001). The G allele (rs846910) of the HSD11ß1 gene was also associated with excess weight (p=0.039). No other association was found. Our results indicate that the ε4 and ε2 alleles could contribute to lower HDL-C and LDL-C levels, respectively, furthermore, the ε3 allele and the G allele (rs846910) of HSD11ß1 gene may be risk factors for excess of weight.These findings are very important because we observed that some genetic variants influence the lipid profile and anthropometric variables early in life.

9.
Gene ; 685: 211-221, 2018 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-30481552

RESUMO

Recent evidences had shown activation of TLR (toll-like receptors) and NLR (nod-like receptors) in response to imbalance in nutrients intake, such as lipid and glucose. The main aim of this study was to investigate possible associations between 11 SNPs in TLR2, TLR4, NLRC4, CARD8 and NEK7 genes and lipid and glucose metabolism. Sample was composed by healthy children and adolescents (n = 158) and adults (n = 115). DNA extraction was obtained by salting-out and sample genotyping by matrix-assisted laser desorption ionization time-of-flight mass spectrometry based system. LDL-cholesterol, HDL-cholesterol, triglycerides, total cholesterol, glucose and insulin were measured by standard automated methods. Means were compared by t-test or Mann-Whitney test. Univariate and multivariate logistic regression were used to verify association between polymorphisms and lipid and glucose markers. Seven polymorphisms in 5 genes were associated with lipid and glucose parameters. For lipid parameters, the following associations were found: higher LDL-C levels and C allele of rs1554973 (TLR4) and G allele of rs6671879 (NEK7); higher HDL-cholesterol levels and A allele of rs13105517 (TLR2); higher total cholesterol and TT genotype of rs3804099 (TLR2) and G allele of rs6671879 (NEK7); higher triglycerides levels and G allele of rs455060 (NLRC4). For glucose parameters associations were found between C allele of rs7258674 (CARD8) and higher glucose levels, and between C allele of rs212704 (NLRC4) and G allele of rs455060 (NLRC4) and insulin levels. These findings indicate a relationship between polymorphisms of TLRs and NLRs genes and markers of lipid and glucose metabolism.

10.
Rev. bras. med. esporte ; 24(5): 361-365, Sept.-Oct. 2018. tab
Artigo em Inglês | LILACS-Express | ID: biblio-977828

RESUMO

ABSTRACT Introduction: Obesity in adolescents has increased worldwide, and is generally associated with poor eating habits and physical inactivity. Objective: To compare absolute and relative muscle strength with body mass (BM), fat-free mass (FFM) and localized FFM of upper and lower limbs among obese and non-obese adolescents. Methods: BM, height and body mass index (BMI) were verified in 39 male adolescents (aged 13-17 years). Body composition was measured by dual-energy X-ray absorptiometry (DXA) and maximal strength of upper and lower limbs was estimated by a one-repetition maximum (1RM) test. Participants were divided into three groups: eutrophic (normal weight) (n=11), overweight (n=14), and obese (n=14). One-way ANOVA was used to compare the variables, followed by a Bonferroni post-hoc test for multiple comparisons. Pearson's correlation coefficient was used for relevant correlations and multiple linear regression to verify the influence of anthropometric variables, body composition and muscle strength of upper and lower limbs. Results: Obese and overweight adolescents had absolute muscle strength values similar to those of the eutrophic adolescents, which were lower when corrected by BM (p<0.001). However, muscle strength related to FFM and localized FFM were similar between groups in both upper and lower limbs. Linear regression showed that BMI explained 59% of the variation in absolute muscle strength of the lower limbs (β=0.59, p<0.05), FFM explained 84% of the variation in absolute muscle strength of the upper limbs (β=0.84, p<0.01) and 68% of the lower limbs (β=0.68; p<0.01), while localized FM was inversely associated in the lower limbs (β=−0.53, p<0.05). Conclusion: Muscle strength of lower and upper limbs, when corrected by localized FFM, does not distinguish between overweight and normal weight adolescents, indicating that obesity does not have a negative effect on generation of muscle strength in obese boys. Level of Evidence III; Case-control study.


RESUMO Introdução: A obesidade em adolescentes tem aumentado em todo o mundo, geralmente associada a hábitos alimentares inadequados e inatividade física. Objetivo: Comparar a força muscular absoluta e relativa com a massa corporal (MC), massa livre de gordura (MLG) e MLG localizada dos membros superiores e inferiores entre adolescentes obesos e não obesos. Métodos: Em 39 adolescentes do sexo masculino (entre 13 e 17 anos) foram verificados MC, estatura e índice de massa corporal (IMC). A composição corporal foi medida por absorciometria de raios-x de dupla energia (DXA) e a força máxima de membros superiores e inferiores foi estimada por um teste de repetição máxima (1RM). Os participantes foram divididos em três grupos: eutrófico (n = 11), sobrepeso (n = 14) e obeso (n = 14). Utilizou-se o teste One-way ANOVA para comparar as variáveis, seguido de teste post hoc de Bonferroni para comparações múltiplas, para as correlações relevantes, usou-se o coeficiente de correlação de Pearson e a regressão linear múltipla foi usada para verificar a influência das variáveis antropométricas, composição corporal e a força muscular dos membros superiores e inferiores. Resultados: Os adolescentes obesos e com sobrepeso tinham força muscular absoluta similar aos dos eutróficos, sendo menores quando corrigidas pela MC (p < 0,001). Porém, a força muscular relacionada com a MLG e a MLG localizada foi semelhante entre os grupos, tanto em membros superiores como inferiores. A regressão linear mostrou que o IMC explicou 59% da variação da força muscular absoluta dos membros inferiores (β = 0,59, p < 0,05), a MLG explicou 84% da variação da força muscular absoluta dos membros superiores (β = 0,84, p < 0,01) e 68% dos membros inferiores (β = 0,68; p < 0,01), enquanto a massa gorda localizada foi inversamente associada nos membros inferiores (β = −0,53; p < 0,05). Conclusão: A força muscular dos membros superiores e inferiores, quando corrigida pela MLG localizada, não diferencia adolescentes com sobrepeso e eutróficos, indicando que a obesidade não afeta negativamente a geração de força muscular em rapazes obesos. Nível de Evidência III; Estudo de caso-controle.


RESUMEN Introducción: La obesidad en adolescentes ha aumentado en todo el mundo, generalmente asociada a malos hábitos alimenticios y falta de actividad física. Objetivo: Comparar fuerza muscular absoluta y relativa de la masa corporal (MC), MLG y MLG localizada en miembros inferiores y superiores entre adolescentes obesos y no obesos. Métodos: Se verificó en 39 adolescentes hombres (entre 13 y 17 años) sus MC, estaturas e índices de masa corporal (IMC). La composición corporal fue mensurada por absorciometría de rayos-x de doble energía (DXA) y el test de repetición máxima para estimar la fuerza máxima de miembros superiores e inferiores, divididos en tres grupos: 11 eutróficos, 14 con sobrepeso y 14 obesos. Se usó ANOVA (one way) para comparación de variables, seguido de Post Hoc de Bonferroni para comparaciones múltiples, correlaciones por el coeficiente de correlación Pearson y Regresión Lineal Múltiple para la influencia de variables antropométricas, composición corporal y fuerza muscular de miembros inferiores y superiores. Resultados: Obesos y con sobrepeso presentaron valores de fuerza muscular absoluta similares a los eutróficos, pero menor si se corrigen por MC (p<0,001). Sin embargo, la fuerza muscular relativa a MLG y MLG localizada fue semejante. En regresión lineal, el IMC explicó el 59% de variación de fuerza muscular absoluta en miembros inferiores (β=0,59, p<0,05), MLG 84% de variación de fuerza muscular absoluta en miembros superiores (β=0,84, p<0,01) y 68% en miembros inferiores (β=0,68; p<0,01), mientras que la MG localizada fue inversamente asociada a los superiores (β=−0,53; p<0,05). Conclusión: La fuerza muscular de miembros superiores e inferiores, cuando es corregida por la MLG localizada, no se diferencia en adolescentes con sobrepeso y eutróficos, indicando que la obesidad no afecta negativamente la generación de fuerza muscular en jóvenes obesos. Nivel de Evidencia III; Estudio caso-control.

11.
J. pediatr. (Rio J.) ; 94(4): 425-431, July-Aug. 2018. tab
Artigo em Inglês | LILACS-Express | ID: biblio-954631

RESUMO

Abstract Objective: To analyze the association between the Trp64Arg polymorphism of the ADRB3 gene, maximal fat oxidation rates and the lipid profile levels in non-obese adolescents. Methods: 72 schoolchildren, of both genders, aged between 11 and 17 years, participated in the study. The anthropometric and body composition variables, in addition to total cholesterol, HDL-c, LDL-c, triglycerides, insulin, and basal glycemia, were evaluated. The sample was divided into two groups according to the presence or absence of the polymorphism: non-carriers of the Arg64 allele, i.e., homozygous (Trp64Trp: n = 54), and carriers of the Arg64 allele (Trp64Arg + Arg64Arg: n = 18), in which the frequency of the Arg64 allele was 15.2%. The maximal oxygen uptake and peak of oxygen uptake during exercise were obtained through the symptom-limited, submaximal treadmill test. Maximal fat oxidation was determined according to the ventilatory ratio proposed in Lusk's table. Results: Adolescents carrying the less frequent allele (Trp64Arg and Arg64Arg) had higher LDL-c levels (p = 0.031) and lower maximal fat oxidation rates (p = 0.038) when compared with non-carriers (Trp64Trp). Conclusions: Although the physiological processes related to lipolysis and lipid metabolism are complex, the presence of the Arg 64 allele was associated with lower rates of FATMAX during aerobic exercise, as well as with higher levels of LDL-c in adolescents.


Resumo Objetivo: Analisar a associação entre o polimorfismo Trp64Arg do gene ADRB3, as taxas de oxidação máxima de gorduras e as concentrações do perfil lipídico em adolescentes não obesos. Métodos: Participaram do estudo 72 escolares, de ambos os sexos, com idade entre 11 e 17 anos. Foram avaliadas as variáveis antropométricas e de composição corporal, além do colesterol total, lipoproteina de alta densidade, lipoproteina de baixa densidade, triglicerídeos; insulina e glicemia basal. A amostra foi dividida em dois grupos, segundo a presença ou não do polimorfismo: não portadores do alelo Arg64, ou seja, homozigotos (Trp64Trp: n = 54) e portadores do alelo Arg64 (Trp64Arg + Arg64Arg: n = 18), em que a frequência do alelo Arg64 foide 15,2%. O consumo máximo de oxigênio e pico de consumo máximo de oxigênio durante o exercício foram obtidos por meio do teste aeróbio submáximo de sintoma limitado em esteira. A oxidação máxima de gorduras foi determinada de acordo com a razão de trocas ventilatórias propostas na Tabela de Lusk. Resultados: Os adolescentes portadores do alelo menos frequente (Trp64Arg e Arg64Arg) apresentaram maiores concentrações de lipoproteina de baixa densidade (p = 0,031) e menores taxasde oxidação máxima de gorduras (p = 0,038) quando comparados aos não portadores (Trp64Trp). Conclusões: Embora os processos fisiológicos relacionados à lipólise e ao metabolismo de lipídeos sejam complexos, a presença do alelo Arg64 associou-se a menores taxas de FATMAX durante exercício aeróbio, bem como maiores níveis de lipoproteina de baixa densidade em adolescentes.

12.
J Obes ; 2018: 3134026, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29854435

RESUMO

Purpose: The rs9939609 SNP (T > A) in FTO gene is associated with obesity and type 2 diabetes. The present study aimed at verifying whether this SNP influenced biochemical outcomes of children and adolescents who are overweight/obese submitted to a program of physical exercise and also if there was influence on basal levels of these biochemical variables. Methods: The sample was composed by 432 children and adolescents grouped in three ways (obese, overweight, and normal weight); of these, 135 children and adoloescents who are obese and overweight were submitted to a physical exercise program for 12 weeks. All were genotyped by TaqMan SNP genotyping assay. Results: The children and adolescents who are overweight/obese and carriers of AA genotype had higher levels of insulin (p=0.03) and HOMA (p=0.007) and lower levels of glucose (p=0.003), but the SNP did not modulate the response to physical exercise. Conclusions: In our study, the rs9939609 AA genotype was associated with parameters related to insulin metabolism but did not interact with physical exercise.

13.
Pensar prát. (Impr.) ; 21(1): 147-155, jan.-mar.2018. Tab, Ilus
Artigo em Português | LILACS | ID: biblio-914125

RESUMO

O presente estudo teve como objetivo verificar o nível de atividade física de adolescentes com Diabetes Melittus Tipo 1 (DM1) e a correlação com a hemoglobina glicada (HbA1c) e identi-ficar qual quantidade mínima de atividade física moderada a vigorosa (AFMV) é necessária para promover benefícios ao controle glicêmico através da HbA1c. Sendo assim, encontrou-se correlação inversa entre HbA1c e AFMV (r=-0,34; p=0,04) e correlação direta entre o IMC escore z e Hba1c (r=0,43; p=0,01). A curva ROC identificou a área sob a curva (AUC) de 70% para 45 minutos de AFMV por dia. Dessa forma, adolescentes diabéticos devem realizar no mínimo 45 minutos por dia de AFMV para promover benefícios ao controle glicêmico avaliado por meio da HbA1c.


This study aimed to verify the level of physical activity of adolescents with diabetes mellitus type 1 (DM1) and the correlation with glycated hemoglobin (HbA1c), and identify the mini-mum amount of moderate to vigorous physical activity (MVPA) is required to promote bene-fits in glycemic control by HbA1c. Thus, found an inverse correlation between HbA1c and MVPA (r= -0.34; p= 0.04) and direct correlation between BMI z score Hba1c (r = 0.43; p = 0.01), the ROC curve identified the area under the curve (AUC) from 70% to 45 minutes MI-PA per day. Thus, diabetic patients should perform at least 45 minutes per day of MVPA to promote benefits in glycemic control assessed by HbA1c.


Este estudio tuvo como objetivo verificar el nivel de actividad física de los adolescentes con diabetes mellitus tipo 1 (DM1) y la correlación con la hemoglobina glucosilada (HbA1c), e identificar la cantidad mínima de actividad física moderada a vigorosa (MVPA) para promo-ver beneficios en el control glucémico mediante la HbA1c. Por lo tanto, se encuentra una co-rrelación inversa entre la HbA1c y moderada a vigorosa (r=-0,34; p= 0,04) y la correlación directa entre el IMC z puntuación de HbA1c (r= 0,43; p= 0,01), la curva ROC identificó el área bajo la curva (AUC) de 70% a 45 minutos MIPA por día. Por lo tanto, los pacientes dia-béticos deben realizar al menos 45 minutos diarios de moderada a vigorosa para promover beneficios en el control glucémico evaluado por la HbA1c.


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Exercício , Índice de Massa Corporal , Adolescente , Diabetes Mellitus Tipo 1
14.
J Pediatr (Rio J) ; 94(4): 425-431, 2018 Jul - Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28941386

RESUMO

OBJECTIVE: To analyze the association between the Trp64Arg polymorphism of the ADRB3 gene, maximal fat oxidation rates and the lipid profile levels in non-obese adolescents. METHODS: 72 schoolchildren, of both genders, aged between 11 and 17 years, participated in the study. The anthropometric and body composition variables, in addition to total cholesterol, HDL-c, LDL-c, triglycerides, insulin, and basal glycemia, were evaluated. The sample was divided into two groups according to the presence or absence of the polymorphism: non-carriers of the Arg64 allele, i.e., homozygous (Trp64Trp: n=54), and carriers of the Arg64 allele (Trp64Arg+Arg64Arg: n=18), in which the frequency of the Arg64 allele was 15.2%. The maximal oxygen uptake and peak of oxygen uptake during exercise were obtained through the symptom-limited, submaximal treadmill test. Maximal fat oxidation was determined according to the ventilatory ratio proposed in Lusk's table. RESULTS: Adolescents carrying the less frequent allele (Trp64Arg and Arg64Arg) had higher LDL-c levels (p=0.031) and lower maximal fat oxidation rates (p=0.038) when compared with non-carriers (Trp64Trp). CONCLUSIONS: Although the physiological processes related to lipolysis and lipid metabolism are complex, the presence of the Arg 64 allele was associated with lower rates of FATMAX during aerobic exercise, as well as with higher levels of LDL-c in adolescents.


Assuntos
Tecido Adiposo/metabolismo , LDL-Colesterol/sangue , Oxirredução , Polimorfismo Genético/genética , Receptores Adrenérgicos beta 3/genética , Adolescente , Alelos , Composição Corporal , Criança , Estudos Transversais , Feminino , Genótipo , Humanos , Masculino
15.
J Pediatr Endocrinol Metab ; 31(9): 1033-1042, 2018 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-30721144

RESUMO

BACKGROUND: The objective of the study was to investigate the response of 64Arg allele carriers of the ADRB3 gene (Trp64Arg polymorphism) in the anthropometric, cardiorespiratory and metabolic variables in overweight adolescents after a 12-week aerobic exercise and nutritional program. METHODS: A total of 92 overweight adolescents, 10-16 years old and of both genders, participated. Body composition, waist circumference (WC), pubertal stage status, blood pressure, glucose, insulin and lipid profile and direct maximal oxygen uptake were assessed at baseline and after 12 weeks of a training program. The homeostasis metabolic assessments [homeostasis model assessment of insulin resistance (HOMA-IR)] and quantitative insulin sensitivity check index (QUICKI) were determined and the Trp64Arg polymorphism of the ADRB3 gene was investigated by Taqman single nucleotide polymorphism (SNP) genotyping assays. Exercise sessions consisted of 100-min aerobic exercise and 20-min stretching, 3 times a week, totalizing 36 sessions. Multivariate analysis of variance (MANOVA), analysis of covariance (ANCOVA) and effect size were used for variables, with p<0.05 considered significant. RESULTS: In baseline, HOMA-IR was higher in carriers of the 64Arg allele and decreased more after 12 weeks than in non-carriers (p=0.01). The anthropometric, physical fitness and metabolic profiles had similar responses after training in carriers and non-carriers. CONCLUSIONS: Overweight adolescents present changes in body composition and physical fitness, independent of Trp64Arg genotypes. However, a 12-week aerobic exercise and nutritional program promoted greater reductions in insulin resistance in carriers of the 64Arg allele.


Assuntos
Alelos , Dieta , Exercício/fisiologia , Resistência à Insulina/genética , Sobrepeso/terapia , Polimorfismo de Nucleotídeo Único , Receptores Adrenérgicos beta 3/genética , Adolescente , Composição Corporal , Criança , Feminino , Genótipo , Comportamentos Relacionados com a Saúde , Humanos , Masculino , Sobrepeso/genética , Resultado do Tratamento
16.
Eur J Nutr ; 2017 Dec 13.
Artigo em Inglês | MEDLINE | ID: mdl-29238857

RESUMO

PURPOSE: The fat mass and obesity-associated (FTO) gene is involved in energy homeostasis. The A allele of the rs9939609 (SNP; T>A) is associated with obesity and higher food intake, while its effect in energy expenditure remains unclear. The aim of this study is to examine whether FTO rs9939609 is associated with the anthropometric outcomes of a physical exercise program and a dietary intervention. METHODS: We studied two independent samples. The first was composed by children and adolescents in which overweight and obese individuals were submitted to a physical exercise program (n = 136) and normal weight participants served as a control group (n = 172). The second sample was composed by obese women submitted to a hypocaloric dietary intervention (n = 126). RESULTS: Physical exercise and dietary intervention were effective, independently of genotype. We found no association of FTO rs9939609 with obesity in children and adolescents (p = 0.67). The rs9939609 affected the response to dietary intervention in obese women: A allele carriers reduced 2.7 cm less of abdominal circumference (AC) than homozygous TT (p = 0.04), while no effect was observed in response to physical exercise in overweight and obese children and adolescents. CONCLUSIONS: The A allele is associated with a worse outcome in response to the hypocaloric dietary intervention regarding abdominal circumference reduction; the same allele did not show interaction with any anthropometric outcomes in response to the exercise program applied.

17.
Rev. bras. cineantropom. desempenho hum ; 19(5): 618-629, Sept.-Oct. 2017. tab, ilus
Artigo em Inglês | LILACS | ID: biblio-897864

RESUMO

Abstract Interval training (HIIT / SIT) combined with resistance training (RT) has been highlighted as a strategy for the improvement of health-related physical fitness markers (HRPF) in adults. Thus, the aim of this meta-analysis was to compare the efficacy of combined training (HIIT / SIT + RT) with other exercise protocols on HRPF markers in adults. A systematic search was performed in MEDLINE via PebMed, Cochrane-CENTRAL, SPORTDiscus, LILACS, SCIELO and Scopus databases between January and March 2017, using the following keywords in English and Portuguese: physical fitness, high-intensity interval training, sprint interval training, resistance training and adults. The quality of studies was evaluated using the PEDro scale. After applying both inclusion and exclusion criteria, nine articles were selected (n = 231). The extraction of means and standard deviations from studies was performed independently by two authors and the RevMan software was used to perform the meta-analysis. Combined training interventions lasted from 6 to 12 weeks and generated greater increase in maximal oxygen uptake than other forms of exercise. The combination of interval training and strength training may be considered more effective to improve aerobic capacity levels in adults.


Resumo O treinamento intervalado (HIIT/SIT) combinado com o treinamento de resistência (TR) tem se destacado como estratégia para a melhora de indicadores de aptidão física relacionados à saúde (AFRS) em adultos. Assim, o objetivo desta meta-análise foi comparar a efetividade do treinamento combinado (HIIT/SIT + TR) com outros protocolos de exercício sobre os indicadores de AFRS em adultos. Foi realizado a busca sistemática nas bases de dados eletrônicas MEDLINE via PubMed, Cochrane-CENTRAL, SPORTDiscus, LILACS, SCIELO e Scopus, entre janeiro e março de 2017, com a utilização dos seguintes descritores, em inglês e português: physical fitness, hight-intensity interval training, sprint interval training, resistance training e adults. A qualidade dos estudos foi avaliada por meio da escala PEDro. Após a aplicação dos critérios de inclusão e exclusão, nove artigos foram selecionados (n= 231). A extração das médias e desvios padrões dos estudos foi realizada de forma independente por dois autores e utilizou-se o programa RevMan na condução da meta-análise. As intervenções com treinamento combinado (HIIT/SIT + TR) tiveram duração de 6 a 12 semanas e produziram maiores aumentos de absorção máxima de oxigênio que outras formas de exercício. A combinação do treinamento intervalado e treinamento de força pode ser considerada mais eficaz para a melhora dos níveis de capacidade aeróbica em adultos.


Assuntos
Aptidão Física , Treinamento de Resistência , Treinamento Intervalado de Alta Intensidade
18.
Rev. bras. ciênc. mov ; 25(2): 167-174, abr.-jun. 2017. tab
Artigo em Português | LILACS | ID: biblio-882255

RESUMO

a presente revisão sistemática busca evidências sobre o efeito agudo da realização de exercícios intermitentes na resposta glicêmica de pessoas com diabetes tipo 1. Métodos: realizaram-se buscas nas bases de dados eletrônicas: Pubmed e Medline. Foram utilizados os seguintes descritores em português e Inglês: Intermittent exercises, interval exercises, intermittent high intensity e diabetes type 1. Foram encontrados 2166 artigos com os descritores mencionados, destes após processo de seleção ficaram 13 artigos para a leitura na integra aonde 06 foram excluídos, assim ao final 07 artigos contemplaram todos os critérios de inclusão e exclusão. O levantamento de dados restringiu-se a pesquisas realizadas com seres humanos de ambos os gêneros nos últimos 10 anos (2005 a 2015). Resultados: observou-se que com a prática de 20 a 60 minutos de exercícios com sprints máximos intermitentes ((variação entre 4 a 30 sprints, tempo de duração 4 a 15 segundos), intervalados com períodos de recuperação passivo ou recuperação ativa de intensidade moderada (40% VO²máx e 50% VO²pico), o que se pode esperar é uma queda glicêmica entre 36 + 14.4mg/dl a 90 + 9mg/dl com valores percentuais entre 18,18% a 54,05%. Conclusão: segundo os estudos analisados o exercício intermitente favorece a um menor risco de hipoglicemias agudas induzidas pelo exercício....(AU)


this current systematic review seeks evidence about the intermittent exercises practicing true effects on the glycemic response of people carrying type 1 diabetes. Methods: Researches were made on electronic databases: PubMed and Medline. The following descriptors were used in Portuguese and English: Intermittent exercises, interval exercises, intermittent high intensity and diabetes type 2166 articles were found with these previous descriptors, after an assortment process, there were 13 articles for full reading in which 06 articles was excluded, thus only 07 articles did fit in all the inclusion and exclusion criteria. The data survey was restricted to researching human beings of both genders in the last 10 years (2005-2015). Results: It was observed that 20-60 minutes practice of exercises with maximum intermittent sprints (about 4-30 sprints, 4-15 seconds duration), with interval periods of passive recovery or moderate intensity active recovery (40% and 50% VO²máx VO²pico), what can be expected is a glycemic decrease between 36 + 14.4mg/dl to 90 + 9 mg/dl and percentages from 18.18% to 54.05%. Conclusion: According to the studies analyzed, intermittent exercises favor a lower risk of acute hypoglycemia induced by exercises....(AU)


Assuntos
Controle , Diabetes Mellitus Tipo 1 , Exercício , Índice Glicêmico , Educação Física e Treinamento
19.
Rev. bras. med. esporte ; 23(1): 12-15, jan.-fev. 2017. tab, graf
Artigo em Português | LILACS-Express | ID: biblio-843960

RESUMO

RESUMO Introdução: O exercício físico é um fator importante do tratamento do diabetes mellitus. Objetivo: Verificar o efeito agudo dos exercícios intermitentes sobre glicemia e oxidação de substratos energéticos em adolescentes com diabetes tipo 1. Métodos: Foram avaliados 10 adolescentes diabéticos com idade entre 10 e 15 anos. Foram avaliadas as medidas antropométricas, hemoglobina glicosilada (HbA1c), VO2máx e o teste de exercício intermitente. Nesse teste, os indivíduos permaneceram pedalando por 30 minutos em cicloergômetro com carga de 60% do VO2máx, intercalados com tiros de intensidades máximas de 10 segundos a cada 5 minutos. Os substratos energéticos foram avaliados durante o teste e a glicemia capilar foi medida antes, imediatamente após o exercício e 30 minutos depois. Foi observada redução média da glicemia de 39,2 ± 41,92 mg/dl, isto é, média de 21,61% da glicemia inicial. Ocorreu diferença significativa (0,0001) entre os substratos energéticos oxidados, com predominância da utilização de CHO. Há uma forte correlação direta entre a HbA1c e o escore z do IMC (r = 0,821, p = 0,004) e entre HbA1c e glicose observadas pós-exercício (r = 0,702, p = 0,024) e também há forte correlação entre os níveis de glicose pré-exercício e pós-exercício (r = 0,851, p = 0,002) e entre pós-exercício e 30 minutos depois do exercício (r = 0,874, p = 0,001). O teste de regressão linear mostrou que o escore z do IMC explica 67% dos valores de HbA1c (r² = 0,675). Resultados: De acordo com os resultados observados, 30 minutos de exercícios aeróbicos intermitentes intercalados com tiros curtos de 10 segundos promovem redução média de 21% da glicemia, com tendência de aumento na fase de recuperação. O substrato energético predominante na atividade são os carboidratos (CHO). Conclusão: Quanto melhor for o escore z do IMC do adolescente, espera-se melhor controle glicêmico em adolescentes com diabetes tipo 1.


ABSTRACT Introduction: Physical exercise is an important factor in the treatment of diabetes mellitus. Objective: To verify the acute effect of intermittent exercises on blood glucose and oxidation of energetic substrates in adolescents with type 1 diabetes. Methods: We evaluated 10 diabetic adolescents aged 10 to 15 years. Anthropometric measurements, glycosylated hemoglobin (HbA1c), VO2max, and the intermittent exercises test were evaluated. In this test, subjects continued pedaling for 30 minutes on a cycle ergometer with a load of 60% of VO2max, interspersed with maximum intensity sprints of 10 seconds every 5 minutes. The energetic substrates were evaluated during the test and the capillary blood glucose was measured before, immediately after exercise, and 30 minutes later. We observed a mean reduction in blood glucose of 39.2 ± 41.92 mg/dl, that is, an average of 21.61% of initial blood glucose. There was a significant difference (0.0001) between the oxidized energetic substrates, predominating the use of CHO. There is a strong direct correlation between HbA1c and the BMI z score (r = 0.821, p = 0.004) and between HbA1c and glucose observed post-exercise (r = 0.702, p = 0.024), and there is a strong correlation between pre-exercise and post-exercise glucose (r = 0.851, p = 0.002) and between post-exercise and 30 minutes after exercise (r = 0.874, p = 0.001). The linear regression test showed that BMI z score accounts for 67% of the HbA1c values (r² = 0.675). Results: According to the results observed, 30 minutes of intermittent aerobic exercises interspersed with short sprints of 10 seconds promoted a mean reduction of 21% in blood glucose with tendency to increase in the recovery phase. The predominant energetic substrates in the activity are carbohydrates (CHO). Conclusion: The better the adolescent BMI z score, the better glycemic control in adolescents with type 1 diabetes is expected.


RESUMEN Introducción: El ejercicio es un factor importante en el control de la diabetes. Objetivo: Investigar el efecto agudo de ejercicio intermitente en la glucemia y la oxidación de sustratos energéticos en adolescentes con diabetes tipo 1. Métodos: Se estudiaron 10 adolescentes diabéticos de 10 a 15 años. Se evaluaron las medidas antropométricas, la hemoglobina glucosilada (HbA1c), el VO2máx, y la prueba de ejercicio intermitente. En esta prueba, los individuos permanecieron pedaleando durante 30 minutos en un cicloergómetro con carga del 60% del VO2máx, intercalados con piques de máxima intensidad de 10 segundos cada 5 minutos. Se evaluaron sustratos energéticos durante la prueba y la glucemia capilar fue medida antes, inmediatamente después del ejercicio y 30 minutos más tarde. Se observó una reducción promedio de la glucemia de 39,2 ± 41,92 mg/dl, es decir, promedio de 21,61% sobre la glucemia inicial. Hubo una diferencia significativa (0,0001) entre los sustratos energéticos oxidados, predominando el uso de CHO. Hay una fuerte correlación directa entre la HbA1c y el IMC puntuación z (r = 0,821, p = 0,004) y entre HbA1c y glucosa observadas después del ejercicio (r = 0,702, p = 0,024) y también hay una fuerte correlación entre los niveles de glucosa pre-ejercicio y post-ejercicio (r = 0,851, p = 0,002) y post-ejercicio y 30 minutos después del ejercicio (r = 0,874, p = 0,001). La prueba de regresión lineal mostró que el IMC puntuación z explica el 67% de los valores de HbA1c (R² = 0,675). Resultados: De acuerdo con los resultados observados, 30 minutos de ejercicio aeróbico intermitente intercalado con piques cortos de 10 segundos promueven una reducción promedio del 21% de glucemia, con una tendencia al aumento en la fase de recuperación. El sustrato energético predominante en la actividad son los carbohidratos (CHO). Conclusión: Cuanto mejor sea la puntuación z del IMC de los adolescentes, mejor control de la glucemia se puede esperar en adolescentes con diabetes tipo 1.

20.
Pediatr Exerc Sci ; 29(2): 213-219, 2017 05.
Artigo em Inglês | MEDLINE | ID: mdl-28050932

RESUMO

The aim of this study was to evaluate the level of physical activity and cardiorespiratory fitness in teenagers with type 1 diabetes mellitus (T1D) in comparison with healthy scholar participants. Total of 154 teenagers (T1D = 45 and CON = 109). Height, weight, cardiorespiratory fitness (VO2max), and the level of physical activity by the Bouchard's Physical Activity Record were measured, and glycated hemoglobin (HbA1c) in T1D. The VO2max was lower in the T1D (38.38 ± 7.54) in comparison with the CON (42.44 ± 4.65; p < .05). The VO2max had correlation with the amount of time of moderate-to-vigorous physical activity (r = .63; p = .0001) and an inverse correlation with sedentary activities (r= -0.46; p = .006). In the T1D the levels of HbA1c had an inverse correlation with the amount of time of moderate-to-vigorous physical activity (r= -0.34; p = .041) and correlation with the BMI z-score (r = .43; p = .017). Only 37,8% of the participants in the T1D reached the adequate amount of daily moderate-to-vigorous intensity physical activity, in the CON 81,7% reached the WHO's recommendation. CONCLUSION: T1D had less cardiorespiratory capacity then healthy controls, the teenagers of T1D with lower BMI z-score and that dedicated a greater time in moderate-to-vigorous intensity physical activity demonstrated a better glycemic control.


Assuntos
Aptidão Cardiorrespiratória/fisiologia , Diabetes Mellitus Tipo 1/fisiopatologia , Diabetes Mellitus Tipo 1/psicologia , Exercício/fisiologia , Adolescente , Biomarcadores/sangue , Estudos de Casos e Controles , Criança , Diabetes Mellitus Tipo 1/sangue , Teste de Esforço , Feminino , Hemoglobina A Glicada/metabolismo , Humanos , Masculino , Comportamento Sedentário , Autorrelato
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