[Skin reactions to the Pfizer-BioNTech vaccine for COVID-19. An Ecuadorian experience]. / Reacciones cutáneas a la vacuna Pfizer-BioNTech contra COVID-19. Una experiencia ecuatoriana.

OBJETIVE: To assess cutaneous reactions after Pfizer-BioNTech COVID-19 vaccine administration. METHODS: A cross-sectional observational study was carried out in health workers belonging to the city of Guayaquil-Ecuador, from March to May 2021. The participants were contacted through a local registry established by the Universidad Espíritu Santo. Frequencies and percentages were used to represent the proportions of nominal variables, while the mean and standard deviation were used for continuous data, given a normal sample distribution. RESULTS: Local skin reactions were the most frequent, and included redness, edema, and itching. On the other hand, delayed large local skin reactions (generalized rash and pruritus, angioedema, urticaria, eczema, petechiae) were rare and occurred in less than 1.4% of participants, (95% CI = 0.69-1.00). Finally, we did not find cases of anaphylaxis or other life-threatening reactions requiring urgent attention after vaccination. CONCLUSIONS: Our findings suggest that local skin reactions occur in a minority of recipients and are often mild and self-limited.

OBJECTIVO: Evaluar las reacciones cutáneas tras la administración de la vacuna COVID-19 de Pfizer-BioNTech. MÉTODOS: Se realizó un estudio observacional transversal en trabajadores de la salud, pertenecientes a la ciudad de Guayaquil-Ecuador, de marzo a mayo de 2021. Los participantes fueron contactados a través de un registro local establecido por la Universidad Espíritu Santo. Se utilizaron frecuencias y porcentajes para representar las proporciones de las variables nominales, mientras que la media y la desviación estándar se usaron para datos continuos, dada la distribución de muestra normal. RESULTADOS: Las reacciones cutáneas locales fueron las más frecuentes e incluyeron enrojecimiento, edema y prurito. Por otro lado, las reacciones cutáneas locales grandes retardadas (exantema y prurito generalizados, angioedema, urticaria, eccema y petequias) fueron raras y ocurrieron en menos de 1.4 % de los participantes, (IC 95 % = 0.69-1.00). Finalmente, no encontramos casos de anafilaxia u otras reacciones potencialmente mortales que requieran atención urgente después de la vacunación. CONCLUSIONES: Nuestros hallazgos sugieren que las reacciones cutáneas locales ocurren en una minoría de personas y que a menudo son leves y autolimitadas.

Relationship Between Resting Heart Rate Variability and Intermittent Endurance Performance in Novice Soccer Players.

Purpose: This study examined the relationships between the Yo-Yo Intermittent Recovery Test level 1 (Yo-Yo IR1) and resting heart rate variability (HRV) and submaximal 5'-5' test derived measures in novice male soccer players. Methods: Forty players (11.54 ± 0.58 years) from a soccer academy participated in this study, performing physical tests on two different days, separated by 48 h, as follows: (day 1) resting HRV and Yo-Yo IR1 test, and (day 2) anthropometric assessments (for peak height velocity assessment [PHV]) and the 5'-5' test. The Pearson product-moment correlation coefficient was used to determine the correlations between Yo-Yo IR1 performance and the remaining variables. A partial correlation analysis was further performed using age, stature, body mass, distance to PHV, and age at PHV as "confounders." Results: The highest correlation score was observed between Yo-Yo IR1 performance and resting HRV, when the absolute age was used as confounder (r = 0.72; p < .05). Conclusions: We observed that a practical measure of parasympathetic activity at rest is largely associated with performance obtained during a traditional intermittent endurance performance test.

Metástasis cutáneas de cáncer de mama: revisión de la literatura / Breast cancer cutaneous metastasis: literature review

Introducción: El cáncer de mama es uno de los tumores malignos más frecuentes en mujeres, y representa el principal carcinoma que genera metástasis cutáneas (MC), excluyendo al melanoma. Objetivos: Realizar una revisión de las MC del carcinoma mamario y mostrar las principales formas de presentación clínica. Discusión: Las MC pueden presentarse mediante diferentes manifestaciones dermatológicas, aunque lo más frecuente es un infiltrado eritematoso papulonodular único o múltiple, generalmente localizado en la piel subyacente o próxima al área del tumor primario. Las células tumorales alcanzan la piel por 3 vías de diseminación: hemática, linfática y por contigüidad. Los carcinomas mamarios, normalmente, se diseminan por la vía linfática y llegan a zonas de la piel cercanas; así, las MC de mama adoptan como sitio de implantación principal la piel del tórax. Conclusiones: Las MC pueden ser la manifestación inicial de un cáncer, o bien un signo de recurrencia de este. Es necesario tener un alto nivel de sospecha diagnóstica debido a su gran polimorfismo clínico.

Introduction: Breast cancer is one of the most frequent malignant tumors in women and is the main carcinoma leading cutaneous metastasis (CMs), excluding melanoma. Objectives: To present a literature review about CMs from breast cancer and to show the mainly clinical forms. Discussion: CMs can present different skin manifestations, but single or multiple papulonodular erythematosus infiltrate are the most common, generally located in the underlying skin or close to the primary tumor area. Tumor cells reach the skin through three dissemination forms -hematogeneus, lymphatic, and contiguity-. Breast carcinomas normally disseminate through lymphatic via and reach close skin zones; thus, breast CMs mainly allocate in the thorax skin. Conclusions: CMs can be the initial manifestation of a cancer or a sign of its recurrence. There must be a high level of suspicion because its clinical polymorphism.

Breast Cancer Metastasis Misdiagnosed as an Angiokeratomatous Eruption. An Infrequent Presentation. Case Report.

INTRODUCTION: Cutaneous metastases represent 2% of all metastases. Breast cancer is the most common cause of skin metastases. Schwartz described 8 types of cutaneous breast metastases; one uncommon form is carcinoma telangiectodes (CT), which may resemble angiosarcoma or lymphangioma circumscriptum. However, there are no reports of CT misdiagnosed as eruptive angiokeratomas. CASE REPORT: The authors describe the clinical, histopathologic, and immunohistochemical features of a unique case of CT. Clinical examination revealed an itchy, dark blue-reddish scaly papular eruption that resembled angiokeratomas. The papules were grouped in a zosteriform pattern on the right chest. A biopsy of the papules revealed intravascular thrombi of neoplastic cells and erythrocytes. The neoplastic cells were pleomorphic and with mitotic figures. Immunohistochemical analysis revealed expression of HER-2-neu in neoplastic cells but negative for estrogen and progesterone receptors. The involved vessels were positive for CD31 and negative for podoplanin. This immunoprofile demonstrated intravascular spread of aggressive breast carcinoma. CONCLUSION: CT is an uncommon form of cutaneous metastasis from breast carcinoma with less than 10 cases described in the literature. There are no previous reported cases of CT mimicking angiokeratomas, although lymphangioma circumscriptum-like lesion may occasionally resemble angiokeratomas. A unique clinical presentation of CT is described.

Preventing texting while driving: a statement of the American College of Preventive Medicine.

The American College of Preventive Medicine (ACPM) is providing a set of recommendations designed to reduce the morbidity and mortality associated with distractions due to texting while driving. According to the National Highway Traffic Safety Administration, 12% of all fatal crashes involving at least one distracted driver are estimated to be related to cell phone use while driving. Given the combination of visual, manual, and cognitive distractions posed by texting, this is an issue of major public health concern for communities. Therefore, the ACPM feels it is timely to discuss this issue and provide the following recommendations: 1. Encourage state legislatures to develop and pass legislation banning texting while driving, while simultaneously implementing comprehensive and dedicated law enforcement strategies including penalties for these violations. Legislatures should establish a public awareness campaign regarding the dangers of texting while driving as an integral part of this legislation. 2. Promote further research into the design and evaluation of educational tools regarding texting while driving that can be incorporated into the issuance of driver's licenses. 3. Provide primary care providers with the appropriate tools to educate patients of all ages. 4. Conduct additional studies investigating the risks associated with cell phone usage while driving, particularly texting, with motor vehicle crashes.