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1.
J Nanobiotechnology ; 20(1): 20, 2022 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-34991596

RESUMO

BACKGROUND: Reactive oxygen species (ROS) have been widely studied for cancer therapy. Nevertheless, instability and aspecific damages to cellular biomolecules limit the application effect. Recently, significant research efforts have been witnessed in the flourishing area of metal nanoclusters (NCs) with atomically precise structures for targeted release of ROS but few achieved success towards targeting tumor microenvironment. RESULTS: In this work, we reported an atomically precise nanocluster Cu6(C4H3N2S)6 (Cu6NC), which could slowly break and generate ROS once encountered with acidic. The as-prepared Cu6NC demonstrated high biological safety and efficient chemodynamic anti-tumor properties. Moreover, Cu6NC enabled transient release of ROS and contained targeting behavior led by the tumor microenvironment. Both in vitro and in vivo experiments confirmed that Cu6NC demonstrated a low cytotoxicity for normal cells, while presented high cytotoxicity for tumor cells with a concentration-dependent manner. CONCLUSIONS: This work not only reported a promising candidate for chemodynamic cancer therapy, but also paved the route to address clinical issues at the atomic level.

2.
Environ Pollut ; 292(Pt A): 118349, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34653588

RESUMO

The adverse effects of fine atmospheric particulate matter with aerodynamic diameters of ≤2.5 µm (PM2.5) are closely associated with particulate chemicals. In this study, PM2.5 samples were collected from highway and industry sites in Hangzhou, China, during the autumn and winter, and their cytotoxicity and pulmonary toxicity and endocrine-disrupting potential (EDP) were evaluated in vitro and in vivo; the particulate polycyclic aromatic hydrocarbons (PAHs), phthalate esters (PAEs), and heavy metals were then characterized. The toxicological results suggested that the PM2.5 from highway site induced higher cytotoxicity (cell viability inhibition, intracellular oxidative stress, and cell membrane injury) and pulmonary toxicity (inflammatory response (IR) and oxidative stress (OS)) than the samples from industry site, while the PM2.5 from industry site exhibited higher EDP (estrogenic and anti-androgenic activity). The cytotoxicity and pulmonary toxicity of PM2.5 in the winter were higher than those in the autumn, while no seasonal difference in the endocrine-disrupting potential was observed (p > 0.05). The Pearson correlation analysis between the biological effects and particulate chemicals revealed that the PM2.5-induced inflammatory response and oxidative stress were closely associated with the particulate PAHs and heavy metals (Pearson correlation coefficients: rIR, PAHs = 0.822-0.988, rIR, heavy metals = 0.895-0.971, rOS, PAHs = 0.843-0.986, and rOS, heavy metals = 0.887-0.933), while particulate di (2-ethylhexyl)phthalate (DEHP) substantially contributed to the EDP of PM2.5 (rEDP, DEHP = 0.981). This study indicated that the toxicity and EDP of PM2.5 could vary with the surrounding environment and season, which was closely associated with the variations of particulate chemicals. Further studies are needed to clarify the associations between the harmful effects of PM2.5 and other contributing factors.


Assuntos
Poluentes Atmosféricos , Metais Pesados , Hidrocarbonetos Policíclicos Aromáticos , Poluentes Atmosféricos/análise , Poluentes Atmosféricos/toxicidade , Animais , China , Monitoramento Ambiental , Ésteres/toxicidade , Humanos , Metais Pesados/análise , Metais Pesados/toxicidade , Camundongos , Material Particulado/análise , Material Particulado/toxicidade , Ácidos Ftálicos , Hidrocarbonetos Policíclicos Aromáticos/análise , Hidrocarbonetos Policíclicos Aromáticos/toxicidade , Estações do Ano
3.
J Cosmet Dermatol ; 2021 Dec 27.
Artigo em Inglês | MEDLINE | ID: mdl-34962051

RESUMO

BACKGROUND: Cosmetic products are widely used in daily life and can cause skin reactions. However, to date, few studies have investigated the prevalence and associated factors of skin reactions to different types of cosmetic products using patch test results. OBJECTIVES: To investigate the frequency and associated factors of skin reactions to sunscreens, skin whitening products, and deodorants using patch test results in China. METHODS: This cross-sectional analysis used data collected during 2004-2017 at the Shanghai Skin Disease Hospital, China. Skin reactions were measured using patch tests following internationally standardized protocols. RESULTS: In total, 151 280 patch tests comprising 16 477 cosmetic products conducted in 4029 healthy volunteers were analyzed. The frequencies of skin reactions to different cosmetic products were 1.07%, 1.28%, and 4.41% for sunscreens, skin whitening products, and deodorants, respectively. With increasing age, a higher frequency of reactions to sunscreens in women (p < 0.001) and a lower frequency of reactions to skin whitening products in men (p < 0.05) were observed. In addition, men were more likely to develop skin reactions to deodorants compared to women (p < 0.05). Skin reactions were more frequent in winter (p < 0.05), which was true for different types of cosmetic products. CONCLUSIONS: The frequency of patch testing for different cosmetic products was 1.07-4.41%. The effects of age, sex, and season vary among the different types of cosmetic products. We hope that these findings can offer guidance for a healthy skincare concept.

4.
Photodiagnosis Photodyn Ther ; 37: 102633, 2021 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-34798345

RESUMO

Chronic hyperplastic candidiasis (CHC) is a chronic oral mucosal infection caused by Candida. Refractory hyperplastic lesions may lead to epithelial dysplasia and carcinogenesis. Traditional surgical resection may cause irreversible damage and effect the patient's quality of life. This paper reports the case of a 63-year-old man with CHC. After routine treatment, local hyperplastic lesions remained. Photodynamic therapy with ALA was applied to the hyperplastic lesions and yielded satisfactory results, with no recurrence at 1 year. This case report describes a promising, effective method for the treatment of CHC.

5.
Biomaterials ; 279: 121179, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34700226

RESUMO

Surgical adhesives have partly replaced traditional sutures to seal and reattach tissues due to their superiorities in preventing liquids leakage and avoiding secondary damage in the surrounding wound area. Most of the existing adhesives are committed to promoting wound healing and functional recovery. A therapeutic adhesive that assists in clearing the residual tumors in the surgical area is undoubtedly meaningful to obtain a better clinical outcome. Herein, enlightened by commercial BioGlue (albumin/glutaraldehyde sealant), a biocompatible therapeutic albumin/genipin bioglue is designed for postoperative wound adhesion and tumor ablation. The albumin/genipin bioglue is formed by simple mixing of bovine serum albumin (BSA) and genipin (GP) under a 35 °C water bath for 24 h without further purification. The obtained dark-blue fluorescent adhesive exhibits a significant temperature increase accompanied by heating-induced curing once irradiated with an 808-nm laser. This unique characteristic allows BSA-GP a therapeutic adhesive for postoperative wound adhesion and photothermal elimination of residual tumors under laser irradiation. Moreover, its easy injectability and impressive photothermal efficacy also make it feasible for in situ tumor photothermal ablation. The ultrasimple synthetic strategy by mimicking BioGlue endows BSA-GP adhesive with large-scale production capacity and clinical transformation potential, which is a successful paradigm for reforming existing clinical products.

6.
Adv Mater ; : e2103192, 2021 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-34363242

RESUMO

Metasurfaces provide a compact and powerful platform for manipulating the fundamental properties of light, and have shown unprecedented capabilities in both optical holographic display and information encryption. For increasing information display/storage capacity, metasurfaces with more polarization manipulation channel and full-color holographic functionality are now an urgent requirement. Here, a minimalist dielectric metasurface with the capability of full-color holography encoded with arbitrary polarization is proposed and experimentally demonstrated. Without the daunting exploratory and computational problem in nanostructure searching, full-color holographic images can be multiplexed into arbitrary polarization channels through vectorial ptychography and k-space ptychography based on tetratomic macropixel geometric phase metasurfaces. Thanks to the full degree of freedom tuning in polarization and color spaces, the application scenarios such as holographic 3D imaging and information encryption are realized. The strategy exhibits promising potential in applications of 3Dl display, augmented/virtual reality, high-density data storage, and encryption.

7.
J Cosmet Dermatol ; 2021 Jul 09.
Artigo em Inglês | MEDLINE | ID: mdl-34240515

RESUMO

BACKGROUND: Patch test, as a helpful tool in clinic diagnosis and safety assessment of cosmetics, is affected by many factors. OBJECTIVES: To investigate the influencing factors of patch test reactions in a highly standardized large-scale dataset of Chinese. METHODS: Patch test data (n = 151,280) from safety assessments of cosmetic products were obtained following internationally standardized patch testing protocols during 2004-2017 in China. RESULTS: The frequency of patch test reactions was 1.45% (2,191/151,280), with majority of the reactions being "score 1" reactions (also known as doubtful reactions, n = 2,075) and a small number being "score 2" reactions (weak reactions, n = 116). Patch test reactions were 67% more frequent in winter (p < 0.001), associated with temperatures (p < 0.001), rather than relative humidity (P:0.29). The frequency of reactions was higher in men than in women (p:0.001), especially in winter. The risk to develop reactions clearly increased with age in women (p < 0.001), but not in men (p:0.14). In women, the frequency of reactions in the old group (≥50 years old) was 30% more than the young group (<30 years old). CONCLUSIONS: The frequency of patch test reactions to cosmetic products was 1.45% in our large-scale study. The influencing factors of patch test include season, sex, and age, which should be considered when conducting and interpreting patch testing.

8.
Genet Sel Evol ; 53(1): 56, 2021 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-34193030

RESUMO

BACKGROUND: Genetic improvement of wool and growth traits is a major goal in the sheep industry, but their underlying genetic architecture remains elusive. To improve our understanding of these mechanisms, we conducted a weighted single-step genome-wide association study (WssGWAS) and then integrated the results with large-scale transcriptome data for five wool traits and one growth trait in Merino sheep: mean fibre diameter (MFD), coefficient of variation of the fibre diameter (CVFD), crimp number (CN), mean staple length (MSL), greasy fleece weight (GFW), and live weight (LW). RESULTS: Our dataset comprised 7135 individuals with phenotype data, among which 1217 had high-density (HD) genotype data (n = 372,534). The genotypes of 707 of these animals were imputed from the Illumina Ovine single nucleotide polymorphism (SNP) 54 BeadChip to the HD Array. The heritability of these traits ranged from 0.05 (CVFD) to 0.36 (MFD), and between-trait genetic correlations ranged from - 0.44 (CN vs. LW) to 0.77 (GFW vs. LW). By integrating the GWAS signals with RNA-seq data from 500 samples (representing 87 tissue types from 16 animals), we detected tissues that were relevant to each of the six traits, e.g. liver, muscle and the gastrointestinal (GI) tract were the most relevant tissues for LW, and leukocytes and macrophages were the most relevant cells for CN. For the six traits, 54 quantitative trait loci (QTL) were identified covering 81 candidate genes on 21 ovine autosomes. Multiple candidate genes showed strong tissue-specific expression, e.g. BNC1 (associated with MFD) and CHRNB1 (LW) were specifically expressed in skin and muscle, respectively. By conducting phenome-wide association studies (PheWAS) in humans, we found that orthologues of several of these candidate genes were significantly (FDR < 0.05) associated with similar traits in humans, e.g. BNC1 was significantly associated with MFD in sheep and with hair colour in humans, and CHRNB1 was significantly associated with LW in sheep and with body mass index in humans. CONCLUSIONS: Our findings provide novel insights into the biological and genetic mechanisms underlying wool and growth traits, and thus will contribute to the genetic improvement and gene mapping of complex traits in sheep.


Assuntos
Peso Corporal/genética , Polimorfismo de Nucleotídeo Único , Ovinos/genética , Transcriptoma , Fibra de Lã/normas , Animais , Estudo de Associação Genômica Ampla/métodos , Leucócitos/metabolismo , Fígado/metabolismo , Macrófagos/metabolismo , Músculo Esquelético/metabolismo , Locos de Características Quantitativas , Característica Quantitativa Herdável , Receptores Nicotínicos/genética , Receptores Nicotínicos/metabolismo , Seleção Artificial , Fatores de Transcrição/genética , Fatores de Transcrição/metabolismo
9.
Bioresour Technol ; 338: 125520, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34284294

RESUMO

Microbial electrolysis cells (MECs) and exogenous accelerants can augment anaerobic digestion performance. Herein, MECs and coconut-shell-derived bio-based carbon (CBC) accelerant are adopted to strengthen anaerobic co-digestion of cow manure and aloe peel waste. The MEC with the voltage of 0.6 V and CBC accelerant of 0.15 wt.% gained the highest cumulative biogas yield (444.20 NmL/g VS) and chemical oxygen demand removal rate (75.46%), which are 80.25% and 58.33% higher than those (246.44 NmL/g VS, 47.66%) of the blank group, respectively. The digestates embodied a utilization potential with thermogravimetric loss of 37.12%-50.67% and total nutrient content of 35.36-51.58 g/kg. These results benefited from excellent electrocatalytic activity of MECs and physicochemical properties of CBC accelerant. A general strategy for understanding improved methanogenesis was proposed based on integrated effects of MECs and CBC accelerant. This work will shed light on development of anaerobic co-digestion by combining MECs and bio-based carbon accelerants.


Assuntos
Aloe , Esterco , Anaerobiose , Animais , Biocombustíveis , Reatores Biológicos , Carbono , Bovinos , Cocos , Digestão , Eletrólise , Metano
10.
Small ; 17(34): e2007576, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34160904

RESUMO

Photocatalytic H2 evolution under solar illumination has been considered to be a promising technology for green energy resources. Developing highly efficient photocatalysts for photocatalytic water splitting is long-term desired but still challenging. Conjugated polymers (CPs) have attracted ongoing attention and have been considered to be promising alternatives for solar-driven H2 production due to the excellent merits of the large π-conjugated system, versatile structures, tunable photoelectric properties, and well-defined chemical composites. The excellent merits have offered numerous methods for boosting photocatalytic hydrogen evolution (PHE) of initial CP-based photocatalysts, whose apparent quantum yield is dramatically increased from <1 to >20% in recent five years. According to the photocatalytic mechanism, this review herein systematically summarizes three major strategies for boosting photocatalytic H2 production of CPs: 1) enhancing visible light absorption, 2) suppressing recombination of electron-hole pairs, and 3) boosting surface catalytic reaction, mainly involving eleven methods, that is, copolymerization, modifying cross-linker, constructing a donor-acceptor structure, functionalization, fabricating organic heterojunction, loading cocatalyst, and surface modification. Finally, the perspectives towards the future development of PHE are proposed.


Assuntos
Hidrogênio , Polímeros , Catálise , Luz , Luz Solar
11.
PLoS One ; 16(6): e0249174, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34086679

RESUMO

BACKGROUND: Breast cancer (BCa) is the most commonly diagnosed cancer and the leading cause of cancer death among females around the world. Recent studies have indicated that long non-coding RNAs (lncRNAs) can serve as an independent biomarker for diagnosis and prognosis in many types of cancer, including pancreatic adenocarcinoma, gastric cancer, liver cancer, and lung cancer. Previous studies have shown that many lncRNAs are associated with the occurrence and development of BCa. However, few studies have combined multiple lncRNAs to predict the prognosis of early-stage BCa patients. METHODS: Systematic and comprehensive analysis of data from The Cancer Genome Atlas (TCGA) was conducted to identify lncRNA signatures with prognostic value in BCa. Additionally, the relative expression levels of the 8 lncRNA of several BCa cell lines were detected by quantitative real-time PCR (qPCR) and the results were substituted into a risk score formula. Finally, migration assays were used to verify the result from prognostic analysis according to the risk scores among cell lines with different risk scores. RESULTS: Our study included 808 BCa patients with complete clinical data. A panel of 8 lncRNAs was identified using Wilcox tests as different between normal and tumor tissue of the BCa patients. This panel was used to analyze the survival of BCa patients. Patients with low risk scores had greater overall survival (OS) than those with high risk scores. Multivariate Cox regression analyses demonstrated that the lncRNA signature was an independent prognostic factor. Gene Set Enrichment Analysis (GSEA) suggested that the lncRNAs might be involved in several molecular signaling pathways implicated in BCa such as the DNA replication pathway, the cell cycle pathway, and the pentose phosphate pathway. Validation experiments in breast cancer cells to test cell migration by using wound-healing assays supported the results of the model. CONCLUSION: Our study demonstrated that a panel of 8 lncRNAs has the potential to be used as an independent prognostic biomarker of BCa.


Assuntos
Neoplasias da Mama/genética , Neoplasias da Mama/patologia , Movimento Celular/genética , RNA Longo não Codificante/genética , Idoso , Biomarcadores Tumorais/genética , Linhagem Celular Tumoral , Feminino , Perfilação da Expressão Gênica/métodos , Regulação Neoplásica da Expressão Gênica/genética , Humanos , Estimativa de Kaplan-Meier , Células MCF-7 , Prognóstico , Transdução de Sinais/genética
12.
Front Pharmacol ; 12: 629513, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33935720

RESUMO

Psoriasis is an immune-mediated chronic inflammatory skin disease primarily mediated by the activation of interleukin (IL)-17-producing T cells. Traditional Chinese Medicine (TCM) represents one of the most effective complementary and alternative medicine (CAM) agents for psoriasis, which provides treasured sources for the development of anti-psoriasis medications. Xiao-Yin-Fang (XYF) is an empirically developed TCM formula that has been used to treat psoriasis patients in Shanghai Changhai Hospital for over three decades. Imiquimod (IMQ)-induced psoriasis-like dermatitis mouse model was utilized to investigate the therapeutic effects of XYF by the assessment of disease severity and skin thickness. Flow cytometric assay was performed to explore the influence of XYF on skin-related immunocytes, primarily T cells. And, RNA sequencing analysis was employed to determine the alternation in gene expression upon XYF therapy. We discovered that XYF alleviated psoriasis-like skin inflammation mainly through suppressing dermal and draining lymph-node IL-17-producing γδT (γδT17) cell polarization. Moreover, XYF therapy ameliorated the relapse of psoriasis-like dermatitis and prohibited dermal γδT cell reactivation. Transcriptional analysis suggested that XYF might regulate various inflammatory signaling pathways and metabolic processes. In conclusion, our results clarified the therapeutic efficacy and inner mechanism of XYF therapy in psoriasis, which might promote its clinical application in psoriasis patients and facilitate the development of novel anti-psoriasis drugs based on the bioactive components of XYF.

13.
Xenobiotica ; 51(7): 818-830, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33952086

RESUMO

Diabetes mellitus is a chronic metabolic disorder with multiple complications, patients who receive metformin may have a simultaneous intake of herbal medicine containing rutaecarpine due to cardiovascular protection and hypolipidemic effects of rutaecarpine. There might be drug interactions between metformin and rutaecarpine. This study aimed to investigate the effects of rutaecarpine on the pharmacodynamics and pharmacokinetics of metformin in diabetic rats.The diabetic rat model was induced with high-fat diet and low dose streptozotocin. Metformin with or without rutaecarpine was administered by oral gavage for 42 days. Pharmacodynamics and pharmacokinetics parameters were evaluated.The pharmacodynamics results revealed that co-administration of rutaecarpine with metformin resulted in a remarkable reduction of serum glucose and lipid profiles in diabetic rats compared to metformin treated alone. The pharmacokinetics results showed that co-treatments of rutaecarpine with metformin did not affect the systemic exposure and renal distribution of metformin, but increased metformin concentration in liver. Furthermore, rutaecarpine increased Oct1-mediated metformin uptake into hepatocytes by upregulation of Oct1 expression in the liver.The above data indicate that rutaecarpine enhanced the anti-diabetic effect of metformin, which may be associated with the increased hepatic distribution of metformin through up-regulation of Oct1 in response to rutaecarpine.


Assuntos
Diabetes Mellitus Experimental , Metformina , Animais , Diabetes Mellitus Experimental/tratamento farmacológico , Humanos , Hipoglicemiantes/farmacologia , Alcaloides Indólicos , Fígado , Metformina/farmacologia , Quinazolinas , Ratos , Regulação para Cima
14.
BMC Infect Dis ; 21(1): 460, 2021 May 20.
Artigo em Inglês | MEDLINE | ID: mdl-34016047

RESUMO

BACKGROUND: This case report describes the clinical process of a shepherd who suffered brucellosis-related endocarditis (BE) and spondylitis (BS) and was infected with Brucella melitensis biovar 3 (B. melitensis biovar 3). CASE PRESENTATION: A 55-year-old male patient was admitted to The First Affiliated Hospital of Shihezi University on October 11, 2018, due to over 3 months of intermittent fever, back pain, and heart trouble. The Rose Bengal Plate test was positive, the standard agglutination test titer for brucellosis was 1/800, and the blood culture was positive for B. melitensis biovar 3. Three instances of transthoracic echocardiography examination at days 1, 25, and 376 after admission to the hospital and magnetic resonance imaging (MRI) and computed tomography (CT) checks at days 5 and 38 revealed that the size of the vegetation on the posterior leaflet of the mitral valve increased from 0.7 × 1.4 cm to 1.2 × 1.5 cm and that the left atrium and ventricle were enlarged. The MRI and CT results showed hyperplasia of the second and third vertebra, a cold abscess formed on both sides of the psoas major muscles, and the vertebra hyperplasia became aggravated at a later time point. The patient's situation deteriorated, and heart failure was discovered on October 22, 2019. At the moment of submission of this manuscript, the patient remains in bed at home because of severe debility caused by brucellosis. CONCLUSIONS: This is the first reported case of endocarditis combined with spondylitis caused by B. melitensis biovar 3 in a shepherd. Brucellosis infection can cause work-power losses because of misdiagnosis or a lack of proper treatment. Early diagnosis and treatment are essential for a successful outcome.


Assuntos
Brucella melitensis , Brucelose/microbiologia , Endocardite Bacteriana/microbiologia , Espondilite/microbiologia , Testes de Aglutinação , Brucelose/diagnóstico , Brucelose/patologia , Endocardite Bacteriana/diagnóstico , Endocardite Bacteriana/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Valva Mitral/microbiologia , Valva Mitral/patologia , Espondilite/diagnóstico
16.
Gut ; 70(7): 1253-1265, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33789966

RESUMO

OBJECTIVE: To characterise the oral microbiome, gut microbiome and serum lipid profiles in patients with active COVID-19 and recovered patients; evaluate the potential of the microbiome as a non-invasive biomarker for COVID-19; and explore correlations between the microbiome and lipid profile. DESIGN: We collected and sequenced 392 tongue-coating samples, 172 faecal samples and 155 serum samples from Central China and East China. We characterised microbiome and lipid molecules, constructed microbial classifiers in discovery cohort and verified their diagnostic potential in 74 confirmed patients (CPs) from East China and 37 suspected patients (SPs) with IgG positivity. RESULTS: Oral and faecal microbial diversity was significantly decreased in CPs versus healthy controls (HCs). Compared with HCs, butyric acid-producing bacteria were decreased and lipopolysaccharide-producing bacteria were increased in CPs in oral cavity. The classifiers based on 8 optimal oral microbial markers (7 faecal microbial markers) achieved good diagnostic efficiency in different cohorts. Importantly, diagnostic efficacy reached 87.24% in the cross-regional cohort. Moreover, the classifiers successfully diagnosed SPs with IgG antibody positivity as CPs, and diagnostic efficacy reached 92.11% (98.01% of faecal microbiome). Compared with CPs, 47 lipid molecules, including sphingomyelin (SM)(d40:4), SM(d38:5) and monoglyceride(33:5), were depleted, and 122 lipid molecules, including phosphatidylcholine(36:4p), phosphatidylethanolamine (PE)(16:0p/20:5) and diglyceride(20:1/18:2), were enriched in confirmed patients recovery. CONCLUSION: This study is the first to characterise the oral microbiome in COVID-19, and oral microbiomes and lipid alterations in recovered patients, to explore their correlations and to report the successful establishment and validation of a diagnostic model for COVID-19.


Assuntos
COVID-19/sangue , COVID-19/microbiologia , Fezes/microbiologia , Lipídeos/sangue , Boca/microbiologia , Adulto , COVID-19/diagnóstico , Estudos de Casos e Controles , China , Estudos de Coortes , Feminino , Microbioma Gastrointestinal , Humanos , Lipidômica , Masculino , Pessoa de Meia-Idade
17.
Neuropharmacology ; 190: 108561, 2021 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-33852823

RESUMO

Arginine vasopressin (AVP), a neuropeptide with widespread receptors in brain regions important for socioemotional processing, is critical in regulating various mammalian social behavior and emotion. Although a growing body of task-based brain imaging studies have revealed the effects of AVP on brain activity associated with emotion processing, social cognition and behaviors, the potential modulations of AVP on resting-state brain activity remain largely unknown. Here, the current study addressed this issue by adopting a machine learning approach to distinguish administration of AVP and placebo, employing the amplitude of low-frequency fluctuation (ALFF) as a measure of resting-state brain activity. The brain regions contributing to the classification were then subjected to functional connectivity and decoding analyses, allowing for a data-driven quantitative inference on psychophysiological functions. Our results indicated that ALFF across multiple neural systems were sufficient to distinguish between AVP and placebo at individual level, with the contributing regions distributed across the social cognition network, sensorimotor regions and emotional processing network. These findings suggest that the role of AVP in socioemotional functioning recruits multiple brain networks distributed across the whole brain rather than specific localized neural pathways. Beyond these findings, the current data-driven approach also opens a novel avenue to delineate neural underpinnings of various neuropeptides or hormones.

18.
Adv Sci (Weinh) ; 8(5): 2002249, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33717836

RESUMO

Atomically dispersed transition metal-N x sites have emerged as a frontier for electrocatalysis because of the maximized atom utilization. However, there is still the problem that the reactant is difficult to reach active sites inside the catalytic layer in the practical proton exchange membrane fuel cell (PEMFC) testing, resulting in the ineffective utilization of the deeply hided active sites. In the device manner, the favorite structure of electrocatalysts for good mass transfer is vital for PEMFC. Herein, a facile one-step approach to synthesize atomically dispersed Fe-N x species on hierarchically porous carbon nanostructures as a high-efficient and stable atomically dispersed catalyst for oxygen reduction in acidic media is reported, which is achieved by a predesigned hierarchical covalent organic polymer (COP) with iron anchored. COP materials with well-defined building blocks can stabilize the dopants and provide efficient mass transport. The appropriate hierarchical pore structure is proved to facilitate the mass transport of reactants to the active sites, ensuring the utilization of active sites in devices. Particularly, the structurally optimized HSAC/Fe-3 displays a maximum power density of up to 824 mW cm-2, higher than other samples with fewer mesopores. Accordingly, this work will offer inspirations for designing efficient atomically dispersed electrocatalyst in PEMFC device.

19.
Microbiol Resour Announc ; 10(12)2021 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-33766900

RESUMO

Two novel Blastococcus sp. clones, TML/M2B and TML/C7B, with 2 different stable growth phenotypes, were isolated from a laboratory tissue culture. The draft genome sequences generated through genomic sequencing of clones TML/M2B and TML/C7B contain 4 and 2 contigs, respectively. The respective genome sizes are 4.10 Mb and 4.11 Mb, with G+C contents of 74.17% and 74.14%, respectively.

20.
Bioresour Technol ; 327: 124793, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33581377

RESUMO

The anaerobic-co-digestion (AcoD) of dairy-manure (DM) and aloe-peel-residue (ALR) waste is enhanced by combining static-magnetic-field (SMF) and fly-ash (FA). Varying SMF intensities (5-30 mT) were applied to the co-digestion digesters containing the optimum FA concentration (1.5 wt.%), which were selected from co-digestion systems with a varying FA (0-2 wt.%). All experimental groups exhibit the greater COD removal rates (51.56-64.19%) and cumulative biogas yields (604.14-671.64 mL/g VS) than reference group (37.77% and 433.19 mL/g VS). The digester with optimum FA concentration (1.5 wt.%) under 5 mT shows the highest biogas yield (671.64 mL/g VS), and exhibits superior digestate stability (45.4%) and fertility (7.01%) for fertilizer utilization. A powerful strategy for understanding the underlying mechanism of the SMF and FA accelerant in an enhanced AcoD system is proposed. This work documents an innovative technique for an enhanced AcoD system using the SMF coupled with FA accelerant.


Assuntos
Reatores Biológicos , Metano , Anaerobiose , Biocombustíveis , Cinza de Carvão , Digestão , Esterco/análise
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