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1.
Aesthetic Plast Surg ; 2022 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-36538055

RESUMO

BACKGROUND: Glabellar filler injection is linked to an increased risk of blindness. A thorough understanding of vascular changes in the glabellar area is critical for safety. The study's goal was to precisely determine the three-dimensional placements of the arteries in the glabellar area. METHODS: In 117 cadavers, the vascular structures in the glabellar area were examined. There were four segments (S1/S1'-S4/S4') and five points (P1-P5) specified. The number of identified arteries found in each section and at each position was tallied. Additionally, the depth of the underlying identified artery under each site was measured. RESULTS: One to three named arteries per glabellar segment were found. Each segment had at least one named artery, and the number of named arteries detected between S1/S1' and S4/S4' decreased. The chance of encountering identified arteries at the 5 designated locations, P1-P5, was 7/117 (6.0%), 6/117 (5.1%), 7/117 (6.0%), 6/117 (5.1%), and 16/117 (13.7%), respectively. At P1-P5, the major artery trunk was 1.8 ± 0.3 mm, 1.6 ± 0.3 mm, 1.4 ± 0.2 mm, 1.3 ± 0.3 mm, and 1.1 ± 0.2 mm below the skin. CONCLUSIONS: The site of the glabellar arteries was clearly shown in this investigation; these arteries were met at a rate of 14% from P1 to P5. We demonstrated that a single entry site through the glabella via cannula could readily keep the needle deep enough for safe glabellar filler injection. LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

2.
Comput Math Methods Med ; 2022: 4018803, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36238468

RESUMO

Background: Uterine fibroids are most common in women aged 30-50 and are the most common benign gynecological tumors. Relevant data suggest that about 25% of patients with uterine fibroids are at childbearing age. Uterine fibroids not only cause the discomfort symptoms, and affect the pregnancy, but also have certain malignant transformation risk, thus needed to be treated positively and promptly. Aim: This study is aimed at exploring the effect of laparoscopic myomectomy and comprehensive rehabilitation nursing on patients with uterine fibroids. Methods: The clinical data of 110 cases of uterine fibroids admitted to our hospital from August 2019 to December 2021 were analyzed retrospectively, and they were divided into two groups according to postoperative rehabilitation strategies. Both groups were treated with laparoscopic myomectomy. The A group was treated with routine rehabilitation strategy, while the B group was treated with comprehensive rehabilitation nursing strategy. The differences in operation-related indicators, stress factors, inflammatory factors, nutritional indicators, knowledge mastery, occurrence of adverse symptoms and pain scores, negative emotion scores, nursing satisfaction, and simplified comfort status scale (GCQ) scores between the two groups under nursing strategies were compared. Results: The postoperative exhaust time (13.14 ± 2.03) h, bed time (9.86 ± 1.94) h, postoperative hospital stay (4.37 ± 1.31) d, and total hospital stay (6.78 ± 1.69) d in the B group were shorter than those in the A group, and the hospitalization expenses (0.74 ± 0.25) million were less than those in the A group (P < 0.05). Before operation, stress factors, inflammatory factors, and nutritional indexes were compared between the two groups (P > 0.05). On the 3rd day after operation, tumor necrosis factor-α (TNF-α), cortisol (Cor), norepinephrine (NE), and interleukin-1ß (IL-1ß) in the two groups showed a significantly upward trend compared with those before operation, and albumin and transferrin were significantly fell compared with those before operation. However, the values of stress factor and inflammatory factor in the B group were significantly lower than those in the A group, and the values after the decrease of nutritional index were significantly higher than those in the A group (P < 0.05). The pain scores at 24 h, 48 h, and 72 h after operation in the B group were significantly lower than those in the A group (P < 0.05). Negative emotions, nursing satisfaction, and GCQ scores were compared between the two groups before intervention (P > 0.05). After the intervention, the scores of Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) in the two groups were significantly lower than those before the intervention, and the scores of nursing satisfaction and GCQ were higher than those before the intervention. The values of negative emotions in the B group after the decline were significantly lower than those in the A group, while the values of nursing satisfaction and GCQ after the increase were higher than those in the A group (P < 0.05). The excellent and good rate of knowledge acquisition in the B group was 94.55% (52/55), which was significantly higher than 78.18% (43/55) in the A group (P < 0.05). The incidence of adverse symptoms in the B group was 9.09% (5/55), which was lower than 21.82% (12/55) in the A group, while the difference was not statistically significant (P > 0.05). Conclusion: Laparoscopic myomectomy combined with comprehensive rehabilitation nursing can reduce the postoperative stress state of patients with uterine fibroids, improve patient satisfaction, reduce adverse emotions, and promote rehabilitation.


Assuntos
Laparoscopia , Leiomioma , Enfermagem em Reabilitação , Miomectomia Uterina , Neoplasias Uterinas , Albuminas , Feminino , Humanos , Hidrocortisona , Interleucina-1beta , Leiomioma/cirurgia , Norepinefrina , Dor/cirurgia , Gravidez , Estudos Retrospectivos , Transferrinas , Fator de Necrose Tumoral alfa , Neoplasias Uterinas/cirurgia
3.
Contrast Media Mol Imaging ; 2022: 2279018, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35935311

RESUMO

The aim of this research was to investigate the predictive role of texture features in computed tomography (CT) images based on artificial intelligence (AI) algorithms for colorectal liver metastases (CRLM). A total of 150 patients with colorectal cancer who were admitted to the hospital were selected as the research objects and randomly divided into three groups with 50 cases in each group. The patients who were found to suffer from the CRLM in the initial examination were included in group A. Patients who were found with CRLM in the follow-up were assigned to group B (B1: metastasis within 0.5 years, 16 cases; B2: metastasis within 0.5-1.0 years, 17 cases; and B3: metastasis within 1.0-2.0 years, 17 cases). Patients without liver metastases during the initial examination and subsequent follow-up were designated as group C. Image textures were analyzed for patients in each group. The prediction accuracy, sensitivity, and specificity of CRLM in patients with six classifiers were calculated, based on which the receiver operator characteristic (ROC) curves were drawn. The results showed that the logistic regression (LR) classifier had the highest prediction accuracy, sensitivity, and specificity, showing the best prediction effect, followed by the linear discriminant (LD) classifier. The prediction accuracy, sensitivity, and specificity of the LR classifier were higher in group B1 and group B3, and the prediction effect was better than that in group B2. The texture features of CT images based on the AI algorithms showed a good prediction effect on CRLM and had a guiding significance for the early diagnosis and treatment of CRLM. In addition, the LR classifier showed the best prediction effect and high clinical value and can be popularized and applied.


Assuntos
Neoplasias Colorretais , Neoplasias Hepáticas , Algoritmos , Inteligência Artificial , Neoplasias Colorretais/diagnóstico por imagem , Neoplasias Colorretais/patologia , Humanos , Neoplasias Hepáticas/diagnóstico , Tomografia Computadorizada por Raios X/métodos
4.
J Occup Environ Med ; 64(10): 889-895, 2022 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-35732041

RESUMO

OBJECTIVE: The aim of this study was to investigate the status of self-efficacy, resilience, personality traits, and job burnout of grassroots civil servants, and their relationship. METHODS: Grassroots civil servants were randomly selected, and questionnaire survey method was adopted. RESULTS: Civil servants with characteristics such as age, marital status, education level, and length of service were more prone to job burnout. Self-efficacy, resilience, and personality traits were important factors influencing job burnout of grassroots civil servants. Neuroticism played a regulating role in the relationship between self-efficacy and mental resilience. The increase of neuroticism score led to increasing mediation of self-efficacy on job burnout through decreased mental resilience. CONCLUSIONS: Higher levels of self-efficacy and mental resilience may reduce job burnout. Higher levels of neuroticism have a negative effect on the moderating role of self-efficacy on job burnout through psychological resilience.


Assuntos
Esgotamento Profissional , Resiliência Psicológica , Esgotamento Profissional/psicologia , Humanos , Satisfação no Emprego , Neuroticismo , Personalidade , Autoeficácia , Inquéritos e Questionários
6.
Food Chem ; 383: 132447, 2022 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-35182875

RESUMO

Chlorophyll (Chl) has great application potential in food colouring and nutritional supplementation. Since Chl is easily degraded, stability protection is vital to its application. Herein, a dual aggregation mechanism induced by high concentrations to improve Chl stability was proposed. As a result, the Chl retention at high concentrations increased to 323.92% of that at low concentrations. To explain aggregation, the Chl dimer was observed by atomic force microscopy, and a stable structural model of the Chl a "sandwich" dimer was established. It was proven that Chl dimer stability was dominated by van der Waals (vdW) interactions, while monomer orientation during aggregation was dominated by electrostatic interactions. Charge transfer (CT) was also shown to be a key interaction in the dimer. Excitation at 393 nm was first proposed for CT identification. This research hopes to provide new ideas for the design of food ingredients in human health promotion.


Assuntos
Clorofila , Clorofila/metabolismo , Clorofila A , Humanos
7.
Food Chem ; 366: 130577, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34293542

RESUMO

The development of green vegetable processing is still limited by the imperfect green protection now. Chlorophyll (Chl), the main pigment presented in green vegetables, was studied that the effects of NaCl on the stability of it, and the synergy of NaCl and high-pressure on Chl protection. Compared to the control, the retention of Chl was increased by 80.14% and the activation energy was 62.7% higher in 7.8% NaCl solution. When the pressure was 600 MPa with 7.8% NaCl, the synergy of NaCl and high-pressure increased the Chl retention by 100%. The restriction of NaCl to H2O provided Chl with a lower polarity environment and increased the contact between Chl molecules. And the fluorescence quenching confirmed the aggregation of Chls induced by high-pressure. This study explains the mechanism of green protection by NaCl and high-pressure, broadening the horizon for the development of color protection in vegetable processing.


Assuntos
Clorofila , Cloreto de Sódio , Espectrometria de Fluorescência
8.
Int J Gen Med ; 14: 9227-9235, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34880662

RESUMO

OBJECTIVE: The occurrence and development mechanisms of melanoma are related to immunity and lncRNAs. Therefore, it is necessary to systematically explore immune-related lncRNA profiles to help improve the prognosis of melanoma. METHODS: We integrated immune-related lncRNAs and the basic clinical information of melanoma patients in the TCGA dataset. Immune-associated lncRNAs were selected by differential expression screening and enriched for analysis. After univariate and multivariate Cox regression analyses, a new prognostic indicator based on immune-associated lncRNAs was established. RESULTS: Overall, differentially expressed immune-related lncRNAs were significantly associated with clinical outcomes in patients with melanoma. A prognostic model was then established based on 14 immune-associated lncRNAs (LRRC8C-DT, AC021188.1, MALINC1, CCR5AS, EIF2AK3-DT, AC022306.2, AC242842.1, AL034376.1, AL662844.4, AC009065.3, AC099811.3, AC125807.2, SPINT1-AS1 and AC009495.2). Melanoma patients in the high-risk group had worse overall survival than those in the low-risk group. The AUC of the risk score was 0.786. CONCLUSION: This study identified several clinically significant immune-related lncRNAs and established a relevant prognostic model, which provided a molecular analysis of immunity in melanoma and potential prognostic lncRNAs for melanoma.

9.
PLoS One ; 16(12): e0261730, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34941945

RESUMO

In this study we investigate how ß-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced expression of markers of an A9 mDA phenotype (KCNJ6, ALDH1A1 and TH) but increased expression of the transcriptional repressors NR0B1 and NR0B2. Overexpression of NR0B1 and or NR0B2 promoted a loss of A9 dopaminergic neuron phenotype markers (KCNJ6, ALDH1A1 and TH). Overexpression of NR0B1, but not NR0B2 promoted a reduction in expression of the ß-catenin-dependent WNT signalling pathway activator RSPO2. Analysis of Parkinson's disease (PD) transcriptomic databases shows a profound PD-associated elevation of NR0B1 as well as reduced transcript for RSPO2. We conclude that reduced ß-catenin-dependent WNT signalling impacts dopaminergic neuron identity, in vitro, through increased expression of the transcriptional repressor, NR0B1. We also speculate that dopaminergic neuron regulatory mechanisms may be perturbed in PD and that this may have an impact upon both existing nigral neurons and also neural progenitors transplanted as PD therapy.


Assuntos
Receptor Nuclear Órfão DAX-1/biossíntese , Neurônios Dopaminérgicos/metabolismo , Regulação para Baixo , Células-Tronco Embrionárias Humanas/metabolismo , Doença de Parkinson/metabolismo , Regulação para Cima , Via de Sinalização Wnt , beta Catenina/metabolismo , Biomarcadores/metabolismo , Receptor Nuclear Órfão DAX-1/genética , Humanos , Doença de Parkinson/genética , beta Catenina/genética
10.
Front Vet Sci ; 8: 736387, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34692811

RESUMO

The blue egg is both of biological interest and economic importance for consumers, egg retailers, and scientists. To date, the genetic mechanisms underlying pigment have mainly focused on protein-coding genes. However, the underpinning mechanism of non-coding RNAs on the pigment deposition among different eggshell colors remains unknown. In this study, RNA sequencing was employed to profile the uterine gland transcriptome (lncRNA and mRNA) of 15 Changshun blue eggshell layers, to better understand the genetic mechanisms of deposition of blue eggshell color. Results showed that differentially expressed mRNAs, GO terms, and KEGG pathways among pink-eggshell and blue-eggshell chickens were mainly targeting immune- and transporter-related terms with the SLC family, IgJ, CD family, and MTMR genes. Furthermore, the progesterone-mediated oocyte maturation and cortisol synthesis and secretion pathway with targeted gene PGR and Pbx1 were significantly enriched between blue- and pink-eggshell chickens. Integrating analysis of lncRNA and mRNA profiles predicted 4 and 25 lncRNA-gene pairs by antisense and cis analysis. They were relative to immune, nerve, and lipids and amino acid metabolisms, porphyrin, and chlorophyll metabolism with targeted gene FECH and oxidative phosphorylation and cardiac muscle contraction pathways with targeted gene COX6A1. Within blue-eggshell chickens, the GO terms hindbrain tangential cell migration and phosphatidylinositol monophosphate phosphatase activity with targeted gene Plxna2 and MTRM1 were identified. Integrating analysis of lncRNA and mRNA profiles predicted 8 and 22 lncRNA-gene pairs. Most pathways were mainly enriched on lipid-related metabolisms as found in mRNA sequencing. The lncRNAs did exert similar functions in color formation by modulating pigment disposition and immune- and lipid-related metabolisms. Our results provide a catalog of chicken uterine lncRNAs and genes worthy of further studies to understand their roles in the selection for blue eggshell color layers.

11.
Aesthet Surg J ; 41(7): NP748-NP757, 2021 06 14.
Artigo em Inglês | MEDLINE | ID: mdl-33621335

RESUMO

BACKGROUND: Results regarding immediate prosthetic breast reconstruction after postmastectomy radiation therapy (PMRT) have been inconsistent. OBJECTIVES: The authors aimed to assess the efficacy and safety of PMRT before immediate prosthetic breast reconstruction for patients with breast cancer. METHODS: Electronic databases (PubMed, EmBase, and the Cochrane Library) were systematically searched to identify eligible studies from their inception until March 2020. The pooled odds ratio (OR) with 95% confidence intervals (CIs) was applied as an effect estimate and calculated using the random-effects model. RESULTS: Nineteen studies including a total of 6757 patients were selected for final meta-analysis. The pooled OR showed that PMRT was associated with a higher incidence of reconstruction failure (OR = 2.57; 95% CI =1.55-4.26; P < 0.001), capsular contracture (OR = 5.99; 95% CI = 3.12-11.47; P < 0.001), and overall complications (OR = 2.52; 95% CI = 1.68-3.79; P < 0.001). It was also associated with a lower incidence of patient satisfaction (OR = 0.29; 95% CI = 0.16-0.52; P < 0.001) and good aesthetic results (OR = 0.25; 95% CI = 0.12-0.52; P < 0.001) compared with those who did not undergo PMRT. These significant associations could be affected by study design, mean age, stage of immediate breast reconstruction, follow-up, and study quality. CONCLUSIONS: Although PMRT is the standard adjuvant therapy for mastectomy patients treated with immediate implant-based breast reconstruction, PMRT for patients undergoing immediate implant-based breast reconstruction has been associated with high risks of reconstruction failure, capsular contracture, and overall complications as well as low incidences of patient satisfaction and good aesthetic results.


Assuntos
Neoplasias da Mama , Mamoplastia , Neoplasias da Mama/radioterapia , Neoplasias da Mama/cirurgia , Feminino , Humanos , Mamoplastia/efeitos adversos , Mastectomia , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Radioterapia Adjuvante/efeitos adversos
12.
Aesthet Surg J ; 41(3): NP127-NP133, 2021 02 12.
Artigo em Inglês | MEDLINE | ID: mdl-32504528

RESUMO

BACKGROUND: Autologous fat is currently one of the most commonly used soft tissue materials in plastic surgery, but the changes that occur in fat after transplantation are unclear. Existing studies on the changes in surviving fat mostly involve animal experiments. OBJECTIVES: The aim of this study was to obtain surviving fat 1 year after clinical autologous fat transplantation for breast augmentation, to explain the microenvironmental changes after fat transplantation from a clinical perspective, and to verify previous research conclusions, thus providing new insight into fat survival. METHODS: Samples of surviving fat were obtained from 5 patients 1 year after they had undergone autologous fat transplantation for breast augmentation, and normal fat samples were obtained from 5 patients who had not undergone this procedure. The differences between CD68 and CD31 were analyzed immunohistochemically, and between CD34 and Ki67 by immunofluorescence. We also tested whether UCP-1 is expressed in surviving fat. RESULTS: The relative CD68, CD34, and Ki67 expression levels in the surviving fat tissue were significantly higher than those in the normal fat tissue (PCD68 = 0.04, PCD34 = 0.03, PKi67 = 0.02). The relative CD31 expression was not significantly different between the two groups (P = 0.52). No UCP-1 expression was observed in any surviving fat tissue. CONCLUSIONS: Chronic inflammatory reactions mediated by macrophages were detectable 1 year after autologous fat transplantation for breast augmentation. The mesenchymal stem cell content in surviving fat was higher than that in normal fat, but the number of blood vessels was close to that in normal breast fat tissue. No genesis of brown fat was found.


Assuntos
Mamoplastia , Células-Tronco Mesenquimais , Tecido Adiposo , Animais , Humanos , Mamoplastia/efeitos adversos , Complicações Pós-Operatórias , Transplante Autólogo
13.
Respir Res ; 22(1): 239, 2021 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-34465322

RESUMO

BACKGROUND: It has been found that up-regulation of histone deacetylases 1 (HDAC1) is involved in the development of pulmonary arterial hypertension (PAH). However, it is still unclear whether inhibition of HDAC1 suppresses the development of PAH via restoring miR-34a level in monocrotaline (MCT)-induced PAH rats. METHODS: PAH rat models were induced by intraperitoneal injection of MCT. HDAC1 was suppressed by intraperitoneal injection of the class I HDAC inhibitor MS-275, and miR-34a was over-expressed via tail vein injection of miR-34a agomiR. RESULTS: HDAC1 protein was significantly increased in MCT-induced PAH rats; this was accompanied with down-regulation of miR-34a and subsequent up-regulation of matrix metalloproteinase 9 (MMP-9)/tissue inhibitor of metalloproteinase 1 (TIMP-1) and MMP-2/TIMP-2. Administration of PAH rats with MS-275 or miR-34a agomiR dramatically abolished MCT-induced reduction of miR-34a and subsequent up-regulation of MMP-9/TIMP-1 and MMP-2/TIMP-2, finally reduced extracellular matrix (ECM) accumulation, pulmonary arterial remodeling, right ventricular systolic pressure (RVSP) and right ventricle hypertrophy index (RVHI) in PAH rats. CONCLUSIONS: HDAC1 contributes to the development of MCT-induced rat PAH by suppressing miR-34a level and subsequently up-regulating the ratio of MMP-9/TIMP-1 and MMP-2/TIMP-2. Inhibition of HDAC1 alleviates pulmonary arterial remodeling and PAH through up-regulation of miR-34a level and subsequent reduction of MMP-9/TIMP-1 and MMP-2/TIMP-2, suggesting that inhibition of HDAC1 might have potential value in the management of PAH.


Assuntos
Histona Desacetilase 1/metabolismo , Inibidores de Histona Desacetilases/farmacologia , Monocrotalina/toxicidade , Artéria Pulmonar/metabolismo , Remodelação Vascular/fisiologia , Animais , Benzamidas/farmacologia , Benzamidas/uso terapêutico , Histona Desacetilase 1/antagonistas & inibidores , Inibidores de Histona Desacetilases/uso terapêutico , Masculino , MicroRNAs/biossíntese , Hipertensão Arterial Pulmonar/induzido quimicamente , Hipertensão Arterial Pulmonar/tratamento farmacológico , Hipertensão Arterial Pulmonar/metabolismo , Artéria Pulmonar/efeitos dos fármacos , Piridinas/farmacologia , Piridinas/uso terapêutico , Ratos , Ratos Sprague-Dawley , Regulação para Cima/efeitos dos fármacos , Regulação para Cima/fisiologia , Remodelação Vascular/efeitos dos fármacos
14.
Cad Saude Publica ; 36(11): e00123719, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33237201

RESUMO

This study aimed to illustrate the impact of injury-related deaths on life expectancy in China in 2016 and to identify the high-risk population. Standard life tables were used to calculate life expectancy and cause-eliminated life expectancy by utilizing mortality data from the national mortality surveillance system. In 2016, the life expectancy of Chinese residents was 78.91 years. After eliminating injury-related mortality, the life expectancy of the residents increased by 1.13 years, which was higher in male and rural residents compared with female and urban residents. The life expectancy on the Eastern and Central regions increased slowly compared with the Western region. The greatest influencing factor on life expectancy was road traffic injuries, followed by falls. Falls had a greater impact on life expectancy for children under 5 years old and those aged over 65 years. This study indicates that deaths caused by injury had a noteworthy impact on life expectancy in China. More attention should be paid to road traffic injuries, and effective preventive measures should be taken to reduce deaths related to injury to increase the life expectancy of residents, especially in children under 5 years and adults over 65 years. By reducing the deaths caused by injury, the life expectancy level is likely to further improve.


Assuntos
Expectativa de Vida , População Rural , Adulto , Idoso , Brasil , Causas de Morte , Criança , Pré-Escolar , China/epidemiologia , Feminino , Humanos , Tábuas de Vida , Masculino
15.
Front Genet ; 11: 994, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33193582

RESUMO

Abnormal methylation of N6 adenosine (m6A) in RNA plays a crucial role in the pathogenesis of many types of tumors. However, little is known about m6A RNA methylation in lung adenocarcinoma. This study aimed to identify the value of m6A RNA methylation regulators in the malignant progression and clinical prognosis of lung adenocarcinoma. The RNA-seq transcriptome data and corresponding clinical information of lung adenocarcinoma were downloaded from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) database. Then the identification of differentially expressed m6A RNA methylation regulators between cancer samples and normal control samples, different subgroups by consensus expression of these regulators and the prognostic signature were achieved using R software with multiple corresponding packages. The results showed that the expression levels of HNRNPC, YTHDF1, KIAA1429, RBM15, YTHDF2, and METTL3 in cancer group were significantly up-regulated (P < 0.05), while expression levels of FTO, ZC3H13, METTL14, YTHDC1 and WTAP in cancer group were significantly down-regulated (P < 0.05) compared with control group. Two subgroups identified by consensus expression of these regulators were closely related to the clinicopathological features, clinical outcomes and malignancy of lung adenocarcinoma. In addition, a 3-gene risk signature including KIAA1429, RBM15, and HNRNPC was constructed and the lung adenocarcinoma patients in TCGA database were divided into high-risk group and low-risk group based on the median risk score. In conclusion, the prognostic signature-based risk score calculated according to the expression levels of KIAA1429, RBM15, and HNRNPC, was not only strongly associated with clinical outcomes and clinicopathological features, but also an independent prognostic factor in lung adenocarcinoma.

16.
Turk J Gastroenterol ; 31(3): 193-204, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32343231

RESUMO

Research conclusions differ on the impact of periampullary diverticulum (PAD) on endoscopic retrograde cholangiopancreatography (ERCP). An up-to-date meta-analysis evaluated the role of PAD in ERCP, especially in terms of cannulation failure and early complications. A comprehensive literature search was performed. All statistical analyses were carried out with the Review Manager 5.3 software. Horizontal lines represented a 95% confidence interval (CI) and the area of each square in forest plots. Twenty-six studies including 23 826 patients with or without PAD who underwent ERCP were evaluated. PAD was associated with an increase in the overall cannulation failure rate (RR=1.46, 95% CI: 1.27-1.67; p<.00001), but in the subgroup of studies performed post-2000, PAD was irrelevant to cannulation failure (RR=1.16, 95% CI: 0.96-1.41; p=0.12). In overall analyses, PAD was also associated with a high risk of ERCP-related pancreatitis (RR=1.32, 95% CI: 1.10-1.59; p=0.003), perforation (RR=1.73, 95% CI: 1.06-2.82; p=0.030), and bleeding (RR=1.48, 95% CI: 1.13-1.93; p=0.005). The presence of PAD increased the overall cannulation failure rate, but not the rate post-2000. PAD also affected the occurrence of early pancreatitis, perforation, and bleeding.


Assuntos
Ampola Hepatopancreática/cirurgia , Cateterismo/efeitos adversos , Colangiopancreatografia Retrógrada Endoscópica/efeitos adversos , Doenças do Ducto Colédoco/complicações , Divertículo/complicações , Complicações Pós-Operatórias/etiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Ampola Hepatopancreática/patologia , Doenças do Ducto Colédoco/patologia , Doenças do Ducto Colédoco/cirurgia , Divertículo/patologia , Divertículo/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
17.
Food Chem ; 318: 126517, 2020 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-32146305

RESUMO

The efficiency of black garlic processing was improved by acceleration of the Maillard reaction after high-pressure pretreatment. The relationship between component changes and the Maillard reaction was analyzed. Three stages of processing were generalized: 1) at the pretreatment stage, the destruction of the cellular structure by high pressure promoted the enzymatic reaction; 2) from 0 to 3 d, the enzymatic reaction was promoted at 45 °C in damaged cells; and 3) after the 3rd day, heating caused the components to change directly. High-pressure pretreatment damaged the intracellular environment, creating reducing sugars for the Maillard reaction that accumulated during the early processing stage, which directly led to the acceleration of the reducing sugar balance point (RSBP). The application of high-pressure pretreatment shortened the production time of black garlic from 24 d to 15 d. Sensory evaluation was performed, and the quality of the black garlic produced in this innovative way met the commercial requirements.


Assuntos
Indústria de Processamento de Alimentos/métodos , Alho/química , Reação de Maillard , Qualidade dos Alimentos , Pressão , Açúcares/química
18.
Sci Rep ; 10(1): 3719, 2020 02 28.
Artigo em Inglês | MEDLINE | ID: mdl-32111899

RESUMO

The production of "Laba" garlic is limited to the homemade method with long processing time and non-uniform color quality. Innovative food processing technologies including high hydrostatic pressure (HHP) and high pressure carbon dioxide (HPCD) were applied to the processing of "Laba" garlic. Products prepared at different treatment pressures (200, 350 and 500 MPa of HHP; 4, 7 and 10 MPa of HPCD) were compared by evaluating the texture, color, flavor and sensory qualities. The results indicated that HHP treatment at 200 MPa was optimal for retaining the textural quality of "Laba" garlic, which was mainly attributed to the compacted cells and the increased Ca2+-cross linked cell-cell adhesion. HHP had greater effect on facilitating the formation of the attractive green color of "Laba" garlic than HPCD. The flavor profiles of "Laba" garlic were modified after treatments, with pungent compounds decreased to non-detectable. The results from sensory study confirmed that "Laba" garlic treated by HHP at 200 MPa was most acceptable to consumers. Moreover, considering the treatment capacity and feasibility of commercialization, HHP would be a promising technology in production of "Laba" garlic with improved quality and efficiency.


Assuntos
Manipulação de Alimentos/métodos , Alho/química , Dióxido de Carbono/química , Cor , Manipulação de Alimentos/instrumentação , Humanos , Pressão Hidrostática , Controle de Qualidade , Paladar
19.
Dermatol Surg ; 46(12): e139-e145, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32217845

RESUMO

BACKGROUND: Facial bony changes vary among races, yet few studies have been conducted in Asians. OBJECTIVE: To analyze the aging of orbital and midfacial bones in Asians. METHODS: Based on the two-dimensional data obtained from the computed tomography scanner of imaging department, 3D reconstructions were conducted to take measurements (orbital diagonal diameter, orbital width, orbital area, maxillary angle, midfacial height, pyriform angle, pyriform width, and pyriform area). RESULTS: In this retrospective study of 261 subjects, a significant decrease in the orbital diagonal diameter, orbital width, and midfacial height was found in men, whereas women displayed a significant increase in the pyriform width and a significant decrease in maxillary angle and midfacial height by three-dimensional analysis. CONCLUSION: This study verifies the minor female changes in the orbital region and less dramatic male changes in the midfacial region compared with that in Caucasians. Individualized treatment should be performed according to different genders and races. Further exploration of facial bone metabolism may have valuable implications for Asians.


Assuntos
Envelhecimento/fisiologia , Remodelação Óssea , Ossos Faciais/fisiologia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Ossos Faciais/diagnóstico por imagem , Feminino , Humanos , Imageamento Tridimensional , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores Sexuais , Tomografia Computadorizada por Raios X , Adulto Jovem
20.
Materials (Basel) ; 13(1)2020 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-31947978

RESUMO

We developed novel Ti-Zr-Be-Co bulk metallic glasses through Co addition based on a ternary Ti45Zr20Be35 alloy. By altering the alloying routes and alloying contents, the influence of Co alloying on glass-forming ability, thermal stability, thermoplastic formability, crystallization behavior, and corrosion resistance has been investigated systematically. It was found that the best alloying route for enhancing the glass-forming ability, thermoplastic formability, compressive plasticity, and corrosion resistance is to replace Be by Co. Ti45Zr20Be23Co12 possesses the largest critical diameter of 15 mm for glass formation. Ti45Zr20Be27Co8 possesses the highest thermoplastic formability which is comparable to that of Vitreloy alloys. Ti45Zr20Be25Co10 exhibits the largest room temperature plasticity of 15.7% together with a high specific strength of 3.90 × 105 Nm/kg. The addition of Co also strongly affects the crystallization behavior of the base alloy, resulting in a more complex crystallization process. The corrosion resistance of Ti-Zr-Be alloy in 1 mol/L HCl solution can also be enhanced by Co alloying. The related mechanisms have been explained in detail, which provide guidance for the composition design of Ti-based metallic glasses with improved properties.

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