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1.
J Colloid Interface Sci ; 605: 667-673, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34364006

RESUMO

Although the electrochemical production of hydrogen has been considered as a promising strategy to obtain the sustainable resources, the sluggish kinetics of anodic oxygen evolution reaction (OER) hindered the sustainable energy development. Herein, we design mesoporous cobalt ferrite phosphides hybridized on reduced graphene oxide (rGO) as a highly efficient bifunctional catalyst through a simple nanocasting method. The hybrid catalyst possesses the abundant interface, which provides the large active sites, as well as the hybrid rGO accelerates the electron exchange and ion diffusion. Moreover, the mesoporous structure not only prevents the aggregation of actives sites, but also benefits for the rapid escape of bubbles during catalytical process, which can significantly improve the catalytic performance. Consequently, the resulting mCo0.5Fe0.5P/rGO shows superior catalytic performance with a low overpotential of 250 mV at a current density of 10 mA cm-2 for OER and outstanding long-term stability. More importantly, an electrolyzer with mCo0.5Fe0.5P/rGO as both anode and cathode catalysts shows a low voltage of 1.66 V to afford a current density of 10 mA cm-2. This work offers a new route for designing the highly efficient OER and overall water splitting electrocatalysts.

2.
J Colloid Interface Sci ; 607(Pt 1): 145-152, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34500415

RESUMO

Metal sulfides are recognized as potential candidates for the anode materials of lithium ion batteries (LIBs) because of their high theoretical capacity. However, the low reaction kinetics of metal sulfides leads to their poor cycle life and rate performance, which limits their practical application in the field of energy storage. In this work, we synthesized a self-assembled carbon-free vanadium sulfide (V3S4) nanosheet via a facile and efficient method. The unique mesoporous nanostructure of V3S4 can not only accelerate the migration of ions/electrons, but also alleviate the volume expansion during the lithium ion insertion/extraction process. When used as the anode material of LIBs, the carbon-free V3S4 electrode exhibits remarkable electrochemical performance with ultra-high charge capacity (1099.3 mAh g-1 at 0.1 A g-1), superior rate capability (668.8 mAh g-1 at 2 A g-1 and 588.8 mAh g-1 at 5 A g-1) and impressive cycling ability (369.6 mAh g-1 after 200 cycles at 10 A g -1), which is very competitive compared with those of most metal sulfides-based anode materials reported so far. The strategy in this work provides inspiration for the rational design of advanced nanostructured electrode materials for energy storage devices.

3.
Sci Total Environ ; : 151380, 2021 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-34780825

RESUMO

This present study investigated detoxification mechanisms of leguminous forage Trifolium pratense L. (red clover) seedlings upon exposure to Ag ions (Ag+) on an atomic level. Depressed plant growth (maximum inhibition rate: 46.57%) and significantly altered antioxidase/antioxidant substances levels (maximum inhibition rate: 65.45%/55.41%) revealed that the physiological metabolism was disturbed. Notable lesions were observed in both leaf and root cells at 588 µM Ag+ treatment. All differentially expressed genes (DEGs) were remarkably mapped to biological metabolism related pathways. Red clover seedlings were speculated to initially transform and immobilize Ag+ in the culture medium, then transporting and fixing them inside the cell, mainly as unreduced Ag+ bound to oxygen-, nitrogen-, sulfur-, chloride-containing biological molecules. A portion of Ag+ was reduced to Ag0 and aggregated to form crystalline argentiferous nanoparticles. Effective reducing agents such as alcohols, carboxylic acid, and etc, which are capable of coordinating heavy metals to reduce and stabilize them, were assumed to play a role in Ag+ reduction. The research results are of great value to understand the defense and tolerance mechanisms of red clover to Ag+ and explore the main existing forms of Ag+ in vivo and in vitro, which could indicate contamination condition in regional ecological environment such as mining area and its potential effects.

4.
J Clin Lab Anal ; : e24104, 2021 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-34762759

RESUMO

The aim of this study is to determine the cut-off value of glucose-6-phosphate dehydrogenase (G6PD) activity and the mutation spectrum of G6PD gene in neonates with G6PD deficiency at Ningbo. Around 82233 neonatal blood samples were measured to determine G6PD activity. The positive samples were further detected with gene analysis. A total of 445 neonates were confirmed as G6PD deficiency, and the incidence in Ningbo was 1/185. 17 types of G6PD gene mutations were found, including 11 single-site mutations and 6 double-site mutations. Considering the significant differences in G6PD activity, the cut-off value was detected to be 2.35 and 3.65 U/gHb for males and females, respectively. Significant differences in G6PD activities were noted and found to be varied from 4.61 to 6.02 U/gHb in different seasons (p < 0.0001). G6PD deficiency screening is a significant detection test for neonatal G6PD deficiency prevention. Our study highlights that the screening should be done using different cut-off values according to the sexes in different seasons.

5.
Artigo em Inglês | MEDLINE | ID: mdl-34780847

RESUMO

BACKGROUND: Deficiency of adenosine deaminase 2 (DADA2) is a recessively inherited autoinflammatory disorder caused by a loss of functional ADA2 protein. TNF inhibition (TNFi) has proven to be highly effective in treating inflammatory manifestations. OBJECTIVE: To explore the pathophysiology and the underlying mechanisms of TNF inhibitor response in these patients. METHODS: We performed Sanger sequencing of the ADA2 gene. We used flow cytometry, intracellular cytokine staining, transcriptome analysis, immunohistochemistry, and cell differentiation experiments to define an inflammatory signature in DADA2 patients and studied their response to TNF inhibitor treatment. RESULTS: We demonstrated increased inflammatory signals and overproduction of cytokines mediated by IFN and NF-κB pathways in patients' primary cells. Treatment with TNFi led to reduction in inflammation, rescued the skewed differentiation towards the pro-inflammatory M1 macrophage subset and restored integrity of endothelial cells in blood vessels. We also report 8 novel disease-associated variants in 7 patients with DADA2. CONCLUSION: Our data explore the cellular mechanism underlying effective treatment with TNFi therapies in DADA2. DADA2 vasculitis is strongly related to the presence of activated myeloid cells and the endothelial cell damage is rescued with anti-TNF treatment.

6.
Sci Rep ; 11(1): 22710, 2021 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-34811461

RESUMO

Thinning is a widely used practice in forest management, but the acclimation mechanisms of fine roots to forest thinning are still unclear. We examined the variations in fine root traits of different branching orders and functional groups along a thinning intensity gradient in a 26-year-old Chinese fir (Cunninghamia lanceolata) plantation. With increasing thinning intensity, the root C concentration (RCC), root N concentration (RNC), specific root area (SRA), and specific root length (SRL) of the absorptive roots (the first two orders) significantly decreased, while root abundance (root biomass and root length density) and root tissue density (RTD) significantly increased. Fifty-four percent of the variation in the absorptive root traits could be explained by the soil N concentration and the biomass and diversity of the understorey vegetation. Conversely, transport root (third- and higher-order) traits did not vary significantly among different thinning intensities. The covariation of absorptive root traits across thinning intensities regarding two dimensions was as follows: the first dimension (46% of the total variation) represented changes in root abundance and chemical traits (related to RCC, RNC), belonging to an extensive foraging strategy; the second dimension (41% of the total variation) represented variations in root morphological traits (related to RTD, SRL and SRA), which is an intensive foraging strategy (i.e., root economic spectrum). These results suggested that the absorptive roots of Chinese fir adopt two-dimensional strategies to acclimate to the altered surroundings after thinning.

7.
J Hazard Mater ; 424(Pt C): 127707, 2021 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-34798547

RESUMO

Co-pollution of antibiotics and metals is prevailing in aquatic environments. However, risks of coexisted antibiotics and metals on aquatic organisms is unclear. This study investigated the combined toxicity of antibiotics and metals towards Synechocystis sp. PCC 6803, a cyanobacterium. We found that the joint toxicity of antibiotics and metals is dependent on their interplays. The complexation between chlortetracycline (CTC) and copper/cadmium (Cu(II)/Cd(II)) resulted in their antagonistic toxicity. Contrarily, an additive toxicity was found between florfenicol (FLO) and Cu(II)/Cd(II) due to lack of interactions between them. CTC facilitated the intracellular uptake of Cu(II) and Cd(II) by increasing the membrane permeability. However, FLO had no obvious effects on the internalization of metals in Synechocystis sp. Proteomic analysis revealed that the photosynthetic proteins was down-regulated by CTC and FLO, and ribosome was the primary target of FLO. These results were verified by parallel reaction monitoring (PRM). Cu(II) induced the up-regulation of iron-sulfur assembly, while Cd(II) disturbed the cyclic electron transport in Synechocystis sp. The co-exposure of CTC and metals markedly alleviated the dysregulation of proteins, while the co-exposure of FLO and metals down-regulated biological functions such as ATP synthesis, photosynthesis, and carbon fixation of Synechocystis sp., compared with their individuals. This supports their joint toxicity effects. Our findings provide better understanding of combined toxicity between multiple pollutants in aquatic environments.

8.
Front Psychol ; 12: 778349, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34777185

RESUMO

[This corrects the article DOI: 10.3389/fpsyg.2021.671232.].

9.
Ann N Y Acad Sci ; 2021 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-34741555

RESUMO

With the widespread popularity of electronic products and the diversification of lighting equipment, ocular photochemical damage caused by light has attracted research attention. Although such equipment mainly cause damage to the retina, the specific pathogenesis has not been systematically elucidated. Thus, the goal of this study was to explore the relationship between mitochondrial dysfunction and the activation of the NOD-like receptor protein 3 (NLRP3) inflammasome in retinal cell death caused by light damage. We used a white light-emitting diode source to establish a mouse model of retinal light damage and observed significant changes of retinal structure and an impairment of visual function. Further experiments revealed that dynamin-related protein 1 (Drp1)-mediated excessive mitochondrial fission induced overproduction of reactive oxygen species in the retinal cells, leading to apoptosis, activation of microglia, and formation of the NLRP3 inflammasome. This, in turn, triggered a series of inflammatory cascade reactions, leading to pyroptosis. We also carried out red light and Drp1 inhibitor treatment and found that retinal damage and the decline in visual function caused by white light could be partially ameliorated. In conclusion, this study clarified the association between mitochondrial dynamics and the NLRP3 inflammasome in retinal light damage and provides opportunities for therapeutic intervention.

10.
Front Oncol ; 11: 743556, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34631581

RESUMO

Exosomes are extracellular vesicles (EVs) that are secreted into body fluids by multiple cell types and are enriched in bioactive molecules, although their exact contents depend on the cells of origin. Studies have shown that exosomes in the tumor microenvironment affect tumor growth, metastasis and drug resistance by mediating intercellular communication and the transport of specific molecules, although their exact mechanisms of action need to be investigated further. In this review, we have summarized current knowledge on the relationship between tumor drug resistance and exosomes, and have discussed the potential applications of exosomes as diagnostic biomarkers and therapeutic targets.

11.
J Ethnopharmacol ; : 114731, 2021 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-34634368

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Fengshi Gutong Capsule (FSGTC) is a traditional Chinese herbal medicine that is composed of seven herbs. It has been widely used for the treatment of joint pain in China. However, the clinical evidence supporting its use in patients with ankylosing spondylitis (AS) is lacking. AIM OF THE STUDY: This study aims to explore the efficacy and safety of FSGTC in the treatment of AS. MATERIALS AND METHODS: This randomized, controlled, double-blinded, double-dummy trial enrolled patients with active AS defined as Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 4 or Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP) ≥ 2.1. Eligible patients were randomized (1:1:1) into combination group (FSGTC plus imrecoxib), FSGTC group (FSGTC plus imrecoxib placebo) or imrecoxib group (imrecoxib plus FSGTC placebo) over a 4-week treatment. The primary endpoint was the composite outcome measure of the Assessment in Ankylosing Spondylitis 20% (ASAS20) response at week 4. The secondary endpoints included ASDAS-CRP, BASDAI, Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI), patient's global assessment of disease activity (PGTA) and safety. RESULTS: Of the 180 randomized patients, 159 patients (88.3%) completed the 4-week treatment. ASAS20 response rate at week 4 was achieved by 27.5% in imrecoxib group, compared with 37.0% in combination group (P > 0.05) and 37.0% in FSGTC group (P > 0.05). In comparison to imrecoxib group, there were significantly greater improvements of ASDAS-CRP and PTGA in combination group and greater improvement of ASDAS-CRP in FSGTC group while the rest of the secondary endpoints shown similar improvement. The incidence of gastrointestinal adverse events in imrecoxib group (15.7%) was significantly higher than that of FSGTC group (1.9%) and without a significant difference to combination group (7.4%). CONCLUSION: FSGTC alone or combined with NSAIDs has therapeutic efficacy in decreasing disease activity of active AS patients and with good gastrointestinal tolerability after 4-week of treatment.

12.
Sci Total Environ ; : 151178, 2021 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-34715234

RESUMO

Simultaneous nitrification, anammox and denitrification (SNAD) system is effective for landfill leachate treatment. However, humic acid (HA) as both an organic pollutant and electron shuttle in landfill leachate, its effects on the SNAD system remain unknown. This study demonstrated that HA initially inhibited NH4+-N removal efficiency due to HA inhibition on anammox bacteria (the lowest fell to 90.89% from 100%), but the HA inhibition was released after adaption in the SNAD system. Hence, the mechanism of releasing HA inhibition in the SNAD system was established from performance, electron transfer and microbial community. Firstly, HA could be effectively removed by an adsorption-biodegradation process in the SNAD system, which avoided deteriorated performance caused by HA accumulation. Electrochemical analysis demonstrated that HA stimulated riboflavin and flavin mononucleotide (FMN) secretion to promote electron transfer efficiency. With the improved electron transfer efficiency, ETSA and ATP values significantly increased, indicating that HA enhanced the microbial metabolism activity of the SNAD system. Further analysis by enzymatic activity assay showed that the HAO (39.68 to 69.53 U/L), AMO (242.94 to 308.36 U/L), HZO (133.73 to 169.65 U/mL), NXR (24.63 to 54.52 U/L), NAR (94.40 to 114.36 U/L) and NIR (104.40 to 123.74 U/L) activities were improved with the HA increased from 0 to 200 mg/L, manifesting that HA enhanced nitrogen metabolism in the SNAD system. Besides, more reasonable metabolic division of labor in functional bacterial and enrichment of heterotrophic bacteria achieved efficient simultaneous removal of HA and nitrogen. Overall, efficient HA biodegradation, faster electron transfer efficiency and better metabolic division of microbial communities released HA inhibition, making the SNAD system more resistant to HA stress. This study shed light on the effects of HA on the SNAD system and provided a new insight for the SNAD system to landfill leachate treatment.

13.
Front Immunol ; 12: 714832, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34603289

RESUMO

Systemic lupus erythematosus (SLE) is a common autoimmune connective tissue disease with unclear etiology and pathogenesis. Mesenchymal stem cell (MSC) and MSC derived extracellular vesicles (EVs) play important roles in regulating innate and adaptive immunity, which are involved in many physiological and pathological processes and contribute to the immune homeostasis in SLE. The effects of MSCs and EVs on SLE have been drawing more and more attention during the past few years. This article reviews the immunomodulatory effects and underlying mechanisms of MSC/MSC-EVs in SLE, which provides novel insight into understanding SLE pathogenesis and guiding the biological therapy.

14.
Artigo em Inglês | MEDLINE | ID: mdl-34498265

RESUMO

OBJECTIVE: To evaluate the relationships of pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) trajectory with adverse perinatal outcomes (APOs). METHODS: A retrospective cohort study was conducted in China, and 12 855 women who had a singleton birth were included. The WHO classification categorized pre-pregnancy BMI, and five GWG trajectories were identified using the latent class growth model. RESULTS: The adjusted odds ratios for the risks of cesarean delivery, preterm birth, and large-for-gestational-age (LGA) infant were significantly higher in women with whoe were overweight or obese pre-pregnancy, but were lower in underweight (except preterm birth) than in normal weight women. Five GWG trajectories were identified: (1) retaining GWG (6.6 kg), (2) moderately slow GWG (10.5 kg), (3) moderate GWG (13.7 kg), (4) moderately fast GWG (16.3 kg), and (5) rapid GWG (19.8 kg). Compared with women in trajectory 3, the risks of cesarean delivery and LGA increase by about 35%-96% for the women in trajectory 4 or 5, whereas the women in trajectory 1 or 2 are inclined to have a higher risk of small for gestational age, but lower risk of LGA. Association of GWG trajectory with APOs varies across pre-pregnancy BMI subgroups. CONCLUSION: This study highlights the influence of inappropriate pre-pregnancy maternal weight and GWG trajectories on the risk of APOs.

15.
J Asthma ; : 1-8, 2021 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-34587470

RESUMO

BACKGROUND: The relationship between childbirth delivery methods and the risk of wheezing in children remains controversial. Few studies have explored it under different maternal conditions. OBJECTIVE: To explore the influence of childbirth delivery method on the onset of wheezing in children of different parity. METHODS: A total of 21716 patients were included in this retrospective observational study. Multivariable logistic regression was used to analyze the relationship between childbirth delivery method and wheezing in children under 18 years of age in Fujian Province. RESULTS: Wheezing differed statistically based on the child's sex, age, season of onset, parity, jaundice history, and feeding patterns (P < 0.05). After adjusting for confounding factors, in cases of parity greater than two, the risk of wheezing in cesarean section deliveries was higher than that in vaginal deliveries (OR: 1.107; 95% CI 1.010-1.214). In girls with parity greater than two (OR: 1.179; 95% CI 1.003-1.387) and normal-weight infants with parity greater than two (OR: 1.106; 95% CI 1.003-1.220), the risk of wheezing in cesarean section deliveries was higher. The interaction term between the mode of childbirth and parity was significant in girls (P = 0.014). CONCLUSION: The method of childbirth delivery and parity are related to the risk of wheezing and may be relevant to gender and birth weight. Parity and gender have synergistic effects on wheezing.

16.
Elife ; 102021 09 20.
Artigo em Inglês | MEDLINE | ID: mdl-34544549

RESUMO

Vaccination strategies for rapid protection against multidrug-resistant bacterial infection are very important, especially for hospitalized patients who have high risk of exposure to these bacteria. However, few such vaccination strategies exist due to a shortage of knowledge supporting their rapid effect. Here, we demonstrated that a single intranasal immunization of inactivated whole cell of Acinetobacter baumannii elicits rapid protection against broad A. baumannii-infected pneumonia via training of innate immune response in Rag1-/- mice. Immunization-trained alveolar macrophages (AMs) showed enhanced TNF-α production upon restimulation. Adoptive transfer of immunization-trained AMs into naive mice mediated rapid protection against infection. Elevated TLR4 expression on vaccination-trained AMs contributed to rapid protection. Moreover, immunization-induced rapid protection was also seen in Pseudomonas aeruginosa and Klebsiella pneumoniae pneumonia models, but not in Staphylococcus aureus and Streptococcus pneumoniae model. Our data reveal that a single intranasal immunization induces rapid and efficient protection against certain Gram-negative bacterial pneumonia via training AMs response, which highlights the importance and the possibility of harnessing trained immunity of AMs to design rapid-effecting vaccine.


Assuntos
Infecções por Acinetobacter/prevenção & controle , Acinetobacter baumannii/imunologia , Vacinas Bacterianas/administração & dosagem , Infecções por Klebsiella/prevenção & controle , Klebsiella pneumoniae/imunologia , Macrófagos Alveolares/efeitos dos fármacos , Pneumonia Bacteriana/prevenção & controle , Infecções por Pseudomonas/prevenção & controle , Pseudomonas aeruginosa/imunologia , Infecções por Acinetobacter/imunologia , Infecções por Acinetobacter/microbiologia , Administração Intranasal , Transferência Adotiva , Animais , Células Cultivadas , Modelos Animais de Doenças , Feminino , Proteínas de Homeodomínio/genética , Imunidade Inata/efeitos dos fármacos , Infecções por Klebsiella/imunologia , Infecções por Klebsiella/microbiologia , Macrófagos Alveolares/imunologia , Macrófagos Alveolares/microbiologia , Macrófagos Alveolares/transplante , Camundongos Endogâmicos C57BL , Camundongos Knockout , Pneumonia Bacteriana/imunologia , Pneumonia Bacteriana/microbiologia , Infecções por Pseudomonas/imunologia , Infecções por Pseudomonas/microbiologia , Fatores de Tempo , Receptor 4 Toll-Like/genética , Receptor 4 Toll-Like/metabolismo , Fator de Necrose Tumoral alfa/genética , Fator de Necrose Tumoral alfa/metabolismo , Vacinação , Vacinas de Produtos Inativados/administração & dosagem
17.
Artigo em Inglês | MEDLINE | ID: mdl-34534435

RESUMO

RATIONALE: Alteration of human respiratory microbiota had been observed in COVID-19. How the microbiota is associated with the prognosis in COVID-19 is unclear. OBJECTIVES: To characterize the feature and dynamics of the respiratory microbiota and its associations with clinical features in COVID-19 patients. Methods:We conducted metatranscriptome sequencing on 588 longitudinal oropharyngeal swab specimens collected from 192 COVID-19 patients (including 39 deceased patients), and 95 healthy controls from the same geographic area. Meanwhile, the concentration of 27 cytokines and chemokines in plasma was measured for COVID-19 patients. MEASUREMENTS AND MAIN RESULTS: The upper respiratory tract (URT) microbiota in COVID-19 patients differed from that in healthy controls, while deceased patients possessed a more distinct microbiota, both on admission and before discharge/death. The alteration of URT microbiota showed a significant correlation with the concentration of proinflammatory cytokines and mortality. Specifically, Streptococcus-dominated microbiota was enriched in recovered patients, and show high temporal stability and resistance against pathogens. In contrast, the microbiota in deceased patients was more susceptible to secondary infections, and became more deviated from the normality after admission. Moreover, the abundance of S. parasanguinis on admission was significantly correlated with prognosis in non-severe patients (lower vs. higher abundance, odds ratio=7.80, [95% CI 1.70-42.05]). Conclusions:URT microbiota dysbiosis is a remarkable manifestation of COVID-19; its association with mortality suggests it may reflect the interplay between pathogens, symbionts, and the host immune status. Whether URT microbiota could be used as a biomarker for the diagnosis and prognosis of respiratory diseases merits further investigation. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).

18.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi ; 35(9): 1167-1171, 2021 Sep 15.
Artigo em Chinês | MEDLINE | ID: mdl-34523283

RESUMO

Objective: To investigate the effects of gender and age on the posterior cranial fossa linear volume and cerebellar tonsil position in normal populations. Methods: A total of 180 normal adults who underwent cervical MRI examination at the physical examination center were selected, including 90 males and 90 females; the age ranged from 20 to 79 years, with an average of 50.4 years. The posterior cranial fossa linear volume and cerebellar tonsil position were measured by two spine surgeons on the mid-sagittal plane of the cervical MRI T2-weighted image. The posterior cranial fossa linear volume included the length of clivus (AB), anteroposterior diameter of foramen magnum (BC), length of supraocciput (CD), anteroposterior diameter of posterior fossa (DA), posterior fossa height (BE), and clivus angle (∠α). The index of the cerebellar tonsil position was the distance from the lower edge of the cerebellar tonsil to the baseline (MN). The differences of each indicators between males and females were compared, and the correlations between age and each indicators were analyzed. Results: The posterior fossa cranial linear volume AB, BC, CD, BE, and ∠α in males were significantly larger than those in females ( P<0.05); DA in males was larger than that in females, but showing no significant difference ( t=1.978, P=0.050). The cerebellar tonsil position (MN) in females was higher than that in males, but showing no significant difference ( t=0.526, P=0.600). Correlation analysis showed that age was negatively correlated with AB, BC, CD, DA, BE, ∠α, and MN ( r=-0.375, P=0.001; r=-0.417, P=0.001; r=-0.046, P=0.001; r=-0.244, P=0.001; r=-0.326, P=0.001; r=-0.320, P=0.001; r=-0.334, P=0.001). Conclusion: The posterior cranial fossa linear volume of normal adults is significantly larger in males than in females; the posterior cranial fossa linear volume and the cerebellar tonsil position may have a decreasing process of age-related degeneration.


Assuntos
Malformação de Arnold-Chiari , Adulto , Idoso , Fossa Craniana Posterior/diagnóstico por imagem , Feminino , Forame Magno , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Tonsila Palatina , Adulto Jovem
19.
Mol Med Rep ; 24(5)2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34558632

RESUMO

Following the publication of the above paper, the authors contacted the Editorial Office to request that the article be retracted on account of the presented results being unreliable; essentially, the authors did not repeat their experiments the requisite number of times, and they were unable to identify in subsequent experiments any increase in the apoptotic rate of the alveolar epithelial cells as had been reported. The Editor of Molecular Medicine Reports has agreed that this paper should be retracted from the Journal. The Editor and the authors apologize to the readership for any inconvenience caused. [the original article was published in Molecular Medicine Reports 16: 9601­9606, 2017; DOI: 10.3892/mmr.2017.7782].

20.
Environ Res ; 204(Pt B): 112086, 2021 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-34562479

RESUMO

The green biogenic PdAu nanoparticles (bio-PdAu NPs) exhibits remarkable catalytic performance in hydrogenation, which is highly desired. However, the catalytic principles and effectiveness of bio-PdxAuy NPs in response to various catalytic systems (electrocatalysis and suspension-catalysis) are unclear. Herein, a facile synthetic strategy for bio-PdxAuy NPs synthesis with controlled size and the catalytic principles for hydrogen evolution reaction (HER) and azo dye degradation is reported. In the biosynthetic process, the size and composition of the bio-PdxAuy NPs could be precisely controlled by predesigning the precursor mass ratio of Pd/Au, and the Au proportion showed a linear relationship with the size of NPs (R2 = 0.92). The obtained bio-PdxAuy NPs exhibit variable activity in electrocatalysis (HER) and suspension-catalysis (azo dye degradation). For electrocatalysis, the formation of conductive networks that facilitates the extracellular electron transfer is crucial. It was revealed that the bio-Pd2Au8 exhibited superior electrocatalytic performance in HER/toward hydrogen evolution, with a maximum current density of 1.65 mA cm-2, which was 1.54 times higher than that commercial Pd/C (1.07 mA cm-2). The high electrocatalytic activity was attributed to its appropriate size (81.38 ± 6.14 nm) and uniform distribution on the cell surface, which promoted the extracellular electron transfer by constructing a conductive network between catalyst and electrode. However, for suspension-catalysis, the size effect and synergistic effect of bimetallic NPs have a more prominent effect on the degradation of azo dyes. As the increase of Au proportion the particle size decreases, and the catalytic activity of bio-PdxAuy improved significantly. The response principles of bio-PdxAuy proposed in this study provide a reliable reference for the rational design of bio-based bimetallic catalysts with enhanced catalytic performance.

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