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1.
Fish Shellfish Immunol ; 104: 622-632, 2020 Jun 22.
Artigo em Inglês | MEDLINE | ID: mdl-32585358

RESUMO

The inhibitory kappa B kinase (IKK) is a critical regulator for the nuclear factor-κB (NF-κB) pathway. In this study, an IKKß named as HLIKKß was identified from the sea cucumber Holothuria leucospilota. The full-length cDNA of HLIKKß is 4246 bp in size, containing a 132 bp 5'-untranslated region (UTR), a 1783 bp 3'-UTR and a 2331 bp open reading frame (ORF) encoding a protein of 776 amino acids with a deduced molecular weight of 89.66 kDa. HLIKKß contains a kinase domain (KD) at its N-terminal, a leucine zipper (LZ) and a helix-loop-helix (HLH) motif at its C-terminal. In the KD, a conserved active loop (SXXXS) were identified. The results of luciferase reporter assay and ELISA assay showed that over-expressed HLIKKß in HEK293T cells could activate the nuclear factor-κB (NF-κB) and induce the secretion of proinflammatory cytokines TNF-α and IL-1ß. When HLIKKß was silenced by siRNA, the apoptosis rate of sea cucumber coelomocytes was increased significantly, indicating the anti-apoptotic function of HLIKKß. Moreover, the up-regulation of HLIKKß mRNA was observed in the sea cucumber coelomocytes after polyriboinosinic polyribocytidylic acid [Poly (I:C)] or lipopolysaccharides (LPS) challenge, suggesting that the HLIKKß might play important roles in the innate immune defense of sea cucumber against the viral and bacterial infections.

2.
Artigo em Inglês | MEDLINE | ID: mdl-32372639

RESUMO

As an important organic intermediate, benzonitrile (BN) is widely involved in organic synthetic chemistry and pharmaceutical and dyestuff industries. However, the exploration of a more efficient and controllable synthesis technique and the corresponding greener catalysts for the synthesis of BN still poses a great challenge. Herein, with multimetallic two-dimensional conductive metal-organic frameworks (2D cMOF) as anodic electrocatalysts, we develop a green, convenient, and highly efficient electrochemical synthesis strategy for BN. Thanks to the intrinsic 2D electrically conductive structure and the optimized the multimetallic coupling catalytic effect, the resulting multimetallic 2D cMOFs exhibit excellent benzylamine (BA) electrooxidation performance. Especially, the trimetallic 2D cMOF (NiCoFe-CAT) requires an ultralow potential of 1.29 V vs reversible hydrogen electrode (RHE) to achieve a 10 mA·cm-2 current density, which indicates the fastest reaction and the most favorable thermodynamic condition. A very high yield (0.058 mmol·mg-1·h-1) and faradic efficiency (∼87%) of benzonitrile are both achieved during the BA electrooxidation reaction at 1.45 V. The reaction mechanism investigations indicated that the various redox mediators of MII/MIII (Ni, Co, Fe) may be regarded as multimetal active species to promote BA conversion. Also, the excellent cycling durability of multimetallic 2D cMOFs further promotes their potential practical applications. These electrocatalytic performances are considered excellent and nearly surpass all other reported Ni-based inorganics or MOF-based electrocatalysts for the electrocatalytic oxidation of benzylamine.

3.
Cell Res ; 30(5): 408-420, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32238901

RESUMO

Social hierarchies emerged during evolution, and social rank influences behavior and health of individuals. However, the evolutionary mechanisms of social hierarchy are still unknown in amniotes. Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals, where mammalian social hierarchies might have initially evolved. Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1 (PAS1, P = 3.15 × 10-18). Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development. PAS1s isolated from various amniotes showed different cis-regulatory activity in vitro, and affected the expression of Lhx2 differently in the nervous system of mouse embryos. PAS1 knock-out mice lack social stratification. PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice, and that social ranks could even be turned over by mutated PAS1. All homozygous mutant mice had normal huddled sleeping behavior, motor coordination and strength. Therefore, PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes, and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies.

4.
Biomed Microdevices ; 22(2): 24, 2020 03 12.
Artigo em Inglês | MEDLINE | ID: mdl-32166408

RESUMO

The porous TiO2 coatings containing Ca/P/Ag were separately prepared on titanium (Ti) surface by one-step (micro-arc oxidation) and two-step methods (micro-arc oxidation and cathodic deposition), and then their surface morphology, composition, biological and antibacterial properties were compared. The results showed that the porous coatings containing Ca/P/Ag achieved by different methods showed similar surface morphology and elemental composition, however, by one-step method, silver existed in the coating as silver phosphate, while in the coatings prepared by two-step method, silver existed as metallic silver. Although both coatings showed excellent antibacterial property (the antimicrobial rate is over 99.9%), the surface coating prepared by one-step method had a more suitable release curve of Ag. In addition, the surface coating prepared by one-step method also presented better biological property, which was due to its enhanced surface roughness and hydrophilicity. Combining with its easy operation and long-term antibacterial property, its prospect for clinical application is more promising.

5.
Artigo em Inglês | MEDLINE | ID: mdl-32222017

RESUMO

The exponential proliferation of data during the information age has required the continuous exploration of novel storage paradigms, materials, and devices with increasing data density. As a step toward the ultimate limits in data density, the development of an electrically controllable single-molecule memristive element is reported. In this device, digital information is encoded through switching between two isomer states by applying a voltage signal to the molecular junction, and the information is read out by monitoring the electrical conductance of each isomer. The two states are cycled using an electrically controllable local-heating mechanism for the forward reaction and catalyzed by a single charge-transfer process for the reverse switching. This single-molecule device can be modulated in situ, is fully reversible, and does not display stochastic switching. The I-V curves of this single-molecule system also exhibit memristive character. These features suggest a new approach for the development of molecular switching systems and storage-class memories.

6.
BMC Infect Dis ; 20(1): 103, 2020 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-32019494

RESUMO

BACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) is an endemic communicable disease in China, accounting for 90% of total reported cases worldwide. In this study, the authors want to investigate the risk factors for HFRS in recent years to provide the prevention and control advices. METHODS: A community-based, 1:2 matched case-control study was carried out to investigate the risk factors for HFRS. Cases were defined as laboratory-confirmed cases that tested positive for hantavirus-specific IgM antibodies. Two neighbourhood controls of each case were selected by sex, age and occupation. Standardized questionnaires were used to collect information and identify the risk factors for HFRS. RESULTS: Eighty-six matched pairs were investigated in the study. The median age of the cases was 55.0 years, 72.09% were male, and 73.26% were farmers. In the multivariate logistic regression analysis, cleaning spare room at home (OR = 3.310, 95%CI 1.335-8.210) was found to be risk factor for infection; storing food and crops properly (OR = 0.279 95%CI 0.097-0.804) provided protection from infection. CONCLUSION: Storing food and crops properly seemed to be protective factor, which was important for HFRS prevention and control. More attention should be paid to promote comprehensive health education and behaviour change among high-risk populations in the HFRS endemic area.


Assuntos
Febre Hemorrágica com Síndrome Renal/etiologia , Adolescente , Adulto , Idoso , Anticorpos Antivirais/sangue , Estudos de Casos e Controles , China , Fazendeiros , Feminino , Vírus Hantaan/imunologia , Vírus Hantaan/patogenicidade , Febre Hemorrágica com Síndrome Renal/transmissão , Humanos , Imunoglobulina M/sangue , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Controle de Roedores
7.
ACS Appl Mater Interfaces ; 12(4): 4432-4442, 2020 Jan 29.
Artigo em Inglês | MEDLINE | ID: mdl-31838854

RESUMO

It is well-known that the formation of ferroalloy with the addition of the second or third metal during the steel-making process usually can improve the performance of the iron. Inspired by ferroalloy materials, it is speculated that the pore environment, framework charge, and catalytic properties of metal-organic frameworks (MOFs) could be optimized dramatically via the introduction of ferroalloy-like inorganic building blocks. However, different to ferroalloy, the accurate integration of different metals into one MOF platform is still challenging. Herein, taking advantages of the good compatibility for metals in trigonal prismatic trinuclear cluster, a series of Fe-based alloy-like [M3O(O2C)6] motifs (M3 = Fe3, Fe1.5Ni1.5, Fe1.5Co1.5, Fe1.5Ti1.5, FeCoNi, and FeTiCo) are successfully generated, which further lead to a robust Fe-MOF material family (SNNU-5s). These multicomponent MOFs not only provide a good chance to explore the impact of pore environment on gas adsorption/separation but also offer an opportunity to the efficient electrocatalytic reaction directly. Accordingly, compared with the SNNU-5-Fe parent structure, the pore characters of heterometallic SNNU-5 MOFs are clearly regulated by the type of alloy-like building blocks. SNNU-5-FeTi displays more superior gas separation performance for CO2/CH4, C2H2/CH4, C2H4/CH4, and C2H2/CO2 gas mixtures. What is more, benefited from the multimetallic active sites and their catalytic synergy, FeCoNi-ternary alloy-like cluster-based SNNU-5 MOF material exhibits an exceptional oxygen evolution reaction activity in aqueous solution at pH = 13, which delivers a low overpotential (ηj=10 = 317 mV), a fast reaction kinetics (Tafel slope = 37 mV dec-1), and excellent catalytic stability. This facile multialloy-like building block strategy holds promise to accurately design and improve the performance of MOFs, as well as open an avenue to understand the related mechanisms.

9.
Acta Physiol (Oxf) ; 228(3): e13374, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31495066

RESUMO

AIM: Apoptosis of vascular smooth muscle cells (VSMCs) influenced by abnormal cyclic stretch is crucial for vascular remodelling during hypertension. Lamin A/C, a nuclear envelope protein, is mechano-responsive, but the role of lamin A/C in VSMC apoptosis is still unclear. METHODS: FX-5000T Strain Unit provided cyclic stretch (CS) in vitro. AnnexinV/PI and cleaved Caspase 3 ELISA detected apoptosis. qPCR was used to investigate the expression of miR-124-3p and a luciferase reporter assay was used to evaluate the ability of miR-124-3p binding to the Lmna 3'UTR. Protein changes of lamin A/C and relevant molecules were detected using western blot. Ingenuity Pathway Analysis and Protein/DNA array detected the potential transcription factors. Renal hypertensive rats verified these changes. RESULTS: High cyclic stretch (15%-CS) induced VSMC apoptosis and repressed lamin A/C expressions compared with normal (5%-CS) control. Downregulation of lamin A/C enhanced VSMC apoptosis. In addition, 15%-CS had no significant effect on mRNA expression of Lmna, and lamin A/C degradation was not induced by autophagy. 15%-CS elevated miR-124-3p bound to the 3'UTR of Lmna and negatively regulated protein expression of lamin A/C. Similar changes occurred in renal hypertensive rats compared with sham controls. Lamin A/C repression affected activity of TP53, CREB1, MYC, STAT1/5/6 and JUN, which may in turn affect apoptosis. CONCLUSION: Our data suggested that the decreased expression of lamin A/C upon abnormal cyclic stretch and hypertension may induce VSMC apoptosis. These mechano-responsive factors play important roles in VSMC apoptosis and might be novel therapeutic targets for vascular remodelling in hypertension.

10.
BMC Genomics ; 20(1): 993, 2019 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-31856713

RESUMO

BACKGROUND: F-box proteins are substrate-recognition components of the Skp1-Rbx1-Cul1-F-box protein (SCF) ubiquitin ligases. By selectively targeting the key regulatory proteins or enzymes for ubiquitination and 26S proteasome mediated degradation, F-box proteins play diverse roles in plant growth/development and in the responses of plants to both environmental and endogenous signals. Studies of F-box proteins from the model plant Arabidopsis and from many additional plant species have demonstrated that they belong to a super gene family, and function across almost all aspects of the plant life cycle. However, systematic exploration of F-box family genes in the important fiber crop cotton (Gossypium hirsutum) has not been previously performed. The genome-wide analysis of the cotton F-box gene family is now possible thanks to the completion of several cotton genome sequencing projects. RESULTS: In current study, we first conducted a genome-wide investigation of cotton F-box family genes by reference to the published F-box protein sequences from other plant species. 592 F-box protein encoding genes were identified in the Gossypium hirsutume acc.TM-1 genome and, subsequently, we were able to present their gene structures, chromosomal locations, syntenic relationships with their parent species. In addition, duplication modes analysis showed that cotton F-box genes were distributed to 26 chromosomes, with the maximum number of genes being detected on chromosome 5. Although the WGD (whole-genome duplication) mode seems play a dominant role during cotton F-box gene expansion process, other duplication modes including TD (tandem duplication), PD (proximal duplication), and TRD (transposed duplication) also contribute significantly to the evolutionary expansion of cotton F-box genes. Collectively, these bioinformatic analysis suggest possible evolutionary forces underlying F-box gene diversification. Additionally, we also conducted analyses of gene ontology, and expression profiles in silico, allowing identification of F-box gene members potentially involved in hormone signal transduction. CONCLUSION: The results of this study provide first insights into the Gossypium hirsutum F-box gene family, which lays the foundation for future studies of functionality, particularly those involving F-box protein family members that play a role in hormone signal transduction.


Assuntos
Proteínas F-Box/genética , Gossypium/genética , Proteínas de Plantas/genética , Proteínas F-Box/classificação , Proteínas F-Box/metabolismo , Duplicação Gênica , Ontologia Genética , Genoma de Planta , Gossypium/metabolismo , Família Multigênica , Reguladores de Crescimento de Planta/fisiologia , Proteínas de Plantas/classificação , Proteínas de Plantas/metabolismo , Proteínas Ligases SKP Culina F-Box/fisiologia , Transdução de Sinais
11.
Opt Express ; 27(22): 32835-32845, 2019 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-31684488

RESUMO

Absorbers have potential applications in the stealth field. However, limited bandwidth and low absorption rate persist in existing methods. Moreover, absorbers working in the low frequency range (1-4 GHz) with small size are much more difficult to realize. In this paper, we propose a novel absorption structure, which combines indium tin oxide film and metal resonator. The former realizes impedance matching with free space in a broad bandwidth at moderate frequency range while the latter shows the resonant property at low frequency. Based on this absorption structure, we design the zigzag-shaped structure to realize high-efficiency and ultra-broadband absorption. To demonstrate the feasibility of our method, we fabricate a sample and perform measurements. The measurement results show that our sample can achieve ultra-broadband absorption with high-efficiency of over 90% from 1 GHz to 18 GHz, which is in good agreement with simulation results. Our findings provide a valuable technique for broadband device design, which could bring about a wide range of applications in cloaking technology.

12.
Sci Rep ; 9(1): 14052, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31575877

RESUMO

Titanium (Ti) is the widely used implant material in clinic, however, failures still frequently occur due to its bioinertness and poor antibacterial property. To improve the biological and antibacterial properties of Ti implants, micro-nanostructured hydroxyapatite (HA) coating was prepared on Ti surface by micro-arc oxidation (MAO), and then the antibacterial agent of chitosan (CS) was loaded on the HA surface through dip-coating method. The results showed that the obtained HA/CS composite coating accelerated the formation of apatite layer in SBF solution, enhanced cell adhesion, spreading and proliferation, and it also inhibited the bacterial growth, showing improved biological and antibacterial properties. Although, with the increased CS amount, the coverage of HA coating would be enlarged, resulting in depressed biological property, however, the antibacterial property of the composite coating was enhanced, and the cytotoxicity about CS was not detected in this work. In conclusion, the HA/CS coating has promising application in orthopedics, dentistry and other biomedical devices.

13.
Inorg Chem ; 58(16): 11220-11230, 2019 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-31368311

RESUMO

The detection of nitro compounds and removal of organic dyes remain urgent issues because they are poisonous to humans. Taking advantage of metal-organic framework (MOF) materials, we demonstrate herein an indium-organic framework (InOF) exhibiting sensitive fluorescence sensing of nitro compounds, prominent dye capture, and excellent photodegradation of dyes. By using 4,4',4″-s-triazine-1,3,5-triyltri-p-aminobenzoate (TATAB), an amino-functionalized BTB-like linker, the 3D SNNU-110 structure ({[In3OCl(H2O)2(TATAB)2]}n) is formed. SNNU-110 shows a 3,6-connected 3,6T22 topology with TATAB and [In3O(CO2)6] tricapped trigonal-prismatic clusters as 3- and 6-connected nodes. Thanks to the fluorescence properties and amine recognition sites of TATAB, SNNU-110 exhibits excellent performance of fluorescence quenching for six electron-deficient nitroaromatics. The intercrossing 1D channels in SNNU-110 formed from the a- and b-axis directions with dimensions of about 18 Å × 11 Å can capture diverse cationic, anionic, or neutral dyes effectively. What is more, the existence of an inorganic [In3O] cluster enable SNNU-110 to be a good photocatalyst. Upon irradiation with a 300 W xenon lamp, SNNU-110 shows outstanding photocatalytic activity toward rhodamine B (RhB) and methylene blue (MB), and there was almost no degradation. The catalytic activity can retain about 94.6% (RhB) and 93.1% (MB), respectively. Overall, SNNU-110 fully demonstrates the power of multicomponent MOFs, which provide a feasible route for the design of functional materials toward to pollutant identification and removal applications.

14.
Fish Shellfish Immunol ; 93: 542-550, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31394160

RESUMO

In this study, an echinoderm tumor necrosis factor receptor named HLTNFR-16 was first cloned from the tropical sea cucumber Holothuria leucospilota. The full-length cDNA of HLTNFR-16 is 3675 bp in size, containing a 415 bp 5'-untranslated region (UTR), a 2024 bp 3'-UTR and a 1236 bp open reading frame (ORF) encoding a protein of 411 amino acids with a deduced molecular weight of 45.63 kDa. The HLTNFR-16 protein contains a signal peptide, four TNFR domains (the last three were identified as extracellular cysteine-rich domains), a transmembrane region and a death domain. Phylogenetic analysis showed that HLTNFR-16 was clustered into a clade with TNFR-16s in other species, indicating that this echinoderm TNFR may be a new member of the TNFR-16 subfamily. The results of TUNEL assay showed that the over expression of HLTNFR-16 could induce apoptosis in HEK293T cells. When HLTNFR-16 was silenced by siRNA, the apoptosis of sea cucumber coelomocytes induced by inactivated Vibrio harveyi was suppressed significantly, indicating that HLTNFR-16 is important for apoptosis induction. Additionally, luciferase reporter assay exhibited that the over-expressed HLTNFR-16 in HEK293T cells could activate the transcription factors nuclear factor-κB (NF-κB) and activator protein-1 (AP-1). Moreover, the secretion of proinflammatory cytokines interleukin (IL)-1ß, IL-6 and IL-18 in HEK293T cells was increased by the over-expression of HLTNFR-16. This study provides evidences for the potential roles of sea cucumber TNFR in the innate immunity.


Assuntos
Regulação da Expressão Gênica/imunologia , Holothuria/genética , Holothuria/imunologia , Imunidade Inata/genética , Receptores do Fator de Necrose Tumoral/genética , Receptores do Fator de Necrose Tumoral/imunologia , Sequência de Aminoácidos , Animais , Sequência de Bases , Filogenia , Receptores do Fator de Necrose Tumoral/química , Alinhamento de Sequência , Vibrio/fisiologia
15.
Angew Chem Int Ed Engl ; 58(38): 13590-13595, 2019 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-31407503

RESUMO

A strategy called ultramicroporous building unit (UBU) is introduced. It allows the creation of hierarchical bi-porous features that work in tandem to enhance gas uptake capacity and separation. Smaller pores from UBUs promote selectivity, while larger inter-UBU packing pores increase uptake capacity. The effectiveness of this UBU strategy is shown with a cobalt MOF (denoted SNNU-45) in which octahedral cages with 4.5 Špore size serve as UBUs. The C2 H2 uptake capacity at 1 atm reaches 193.0 cm3 g-1 (8.6 mmol g-1 ) at 273 K and 134.0 cm3 g-1 (6.0 mmol g-1 ) at 298 K. Such high uptake capacity is accompanied by a high C2 H2 /CO2 selectivity of up to 8.5 at 298 K. Dynamic breakthrough studies at room temperature and 1 atm show a C2 H2 /CO2 breakthrough time up to 79 min g-1 , among top-performing MOFs. Grand canonical Monte Carlo simulations agree that ultrahigh C2 H2 /CO2 selectivity is mainly from UBU ultramicropores, while packing pores promote C2 H2 uptake capacity.

16.
Biomater Sci ; 7(10): 4075-4087, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31355387

RESUMO

Titanium (Ti) is a widely used implant material in clinics; however, failures still frequently occur due to its bioinertness and poor antibacterial capability. Post-implant infections most likely occur within the first two weeks. Thereafter, the host immune system lowers the infection risk, and biosafety becomes the first consideration. Therefore, endowing biomedical Ti with a time-dependent bactericidal effect is of considerable interest. In this study, Ag nanoparticles (NPs) as the antibacterial agent were incorporated deeply into TiO2 nanotubes prepared on the sandblasted and etched (SLA) Ti surface. The incorporated Ag NPs were verified to automatically transform from a free state to an immobilized state, rendering the constructed platform exhibit a self-adjusting antibacterial effect. It showed strong "release bactericidal" activity in the early phase that gradually changed to the "contact bactericidal" ability. Such a smart alteration could satisfy the varied antibacterial requirements in different periods after biomaterial implantation. Moreover, the nanotubular structure could accelerate apatite formation and improve cell adhesion and proliferation when compared with those of commercially used SLA implants. Based on these results, it can be concluded that Ag-NP-incorporated micro-nanostructured Ti has worthwhile biological and time-dependent antibacterial properties, and it can have promising applications in orthopedics, dentistry, and fabrication of other biomedical devices.


Assuntos
Antibacterianos/administração & dosagem , Nanopartículas Metálicas/administração & dosagem , Nanotubos , Prata/administração & dosagem , Titânio/administração & dosagem , Animais , Linhagem Celular , Proliferação de Células/efeitos dos fármacos , Escherichia coli/efeitos dos fármacos , Escherichia coli/crescimento & desenvolvimento , Camundongos , Staphylococcus aureus/efeitos dos fármacos , Staphylococcus aureus/crescimento & desenvolvimento
17.
Artigo em Inglês | MEDLINE | ID: mdl-31234271

RESUMO

Ethnic minority areas in southwestern China are facing frequent high-temperature heatwaves. The health risk perceptions and responses of the local residents need to be investigated in order to formulate public policies to mitigate the impacts of climate change on health. In this study, a household survey was conducted in Pengshui Miao and Tujia Autonomous County of Chongqing from January to February 2019. A total of 624 local residents were sampled using the multi-stage sampling method. We used multivariate logistic regression models to explore the factors affecting risk perceptions and responses with regard to hot weather. The results showed that despite a relatively high level of risk perception, the study population had a very low level of willingness to see a doctor (24.4%), especially ethnic minority residents (17.5%). In particular, 80% of residents were aware of climate warming and 79% of residents were aware of the health risks of hot weather. Almost all survey participants reported a response to hot weather, with more than half of the participants stating that they would go somewhere cooler (58.5%) and drink more water (56.3%). Compared with the Han Chinese, ethnic minority participants had a higher perception of warm temperature (p <0.001) and associated health risks (p <0.001) but a lower perception of physical discomfort (p <0.001) and aggravated diseases (p = 0.001). The logistic models indicated that ethnic minority, residence time, outdoor working hours, and health status can significantly influence perceptions and subsequently significantly affect coping behaviors. In conclusion, our findings provide significant implications for the development of policies and health education and promotion programs for ethnic minorities in southwest China to aid them in maintaining good health during future hot weather events.


Assuntos
Grupos Étnicos , Temperatura Alta , Grupos Minoritários , Percepção , População Rural , Adaptação Psicológica , Adulto , China , Mudança Climática , Estudos Transversais , Feminino , Educação em Saúde , Nível de Saúde , Humanos , Modelos Logísticos , Masculino , Inquéritos e Questionários
18.
Opt Express ; 27(10): 14942-14950, 2019 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-31163935

RESUMO

A perfect absorber is highly desired in many engineering applications, including cloaking devices and sensor detectors, but most types of absorbers with chirality-dependence have limited bandwidth. In this paper, we propose a novel broadband and chirality-dependent metasurface absorber that consists of an array of planar spiral elements. The spiral orientation can determine the absorption polarization, such as counterclockwise for right circular polarization (RCP) absorption and clockwise for left circular polarization (LCP) absorption. Three steps are adopted to enhance the absorption bandwidth: carefully optimizing the spiral turns, impedance of load resistor, and introducing a matching layer. To demonstrate our concept, we have designed and fabricated a realistic metasurface absorber. The numerical simulations are in good agreement with the experimental results. The simulation and measurement results demonstrate that this device can achieve a broadband (8.3-18 GHz) absorption for RCP incidence, while reflecting the LCP incident waves between 9 GHz to 17.8 GHz without changing its chirality. Our findings explore a novel way to realize broadband absorption and simultaneously provide a new strategy to design chirality-dependent multi-functional meta-devices.

19.
Sci Total Environ ; 683: 638-647, 2019 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-31150884

RESUMO

Coal gangue and phenol are two main pollutants in coal mining and processing. Using coal gangue as raw material, a series of Cu modified ZSM-5 (Cu/ZSM-5) catalysts were developed to remove phenol through heterogeneous Fenton-like reaction. This procedure implies the concept of waste control by waste. The characterization results showed that Cu modification had no obvious impact on the MFI (Mobile Five) structure of ZSM-5. Copper ions were presented as doping element (substitution of Na and Al ions) and copper oxides on ZSM-5 surface. The XPS spectra suggested the co-existence of Cu2+ and Cu+. As a consequence of well-defined experimental parameters, 7% Cu/ZSM-5 performed excellent activity and stability for the degradation and mineralization of phenol pollutant, which could degrade phenol completely within 30min and the TOC removal efficiency could reach 63% within 60min and 92% within 8h. ESR and radicals capturing experiments demonstrated that OH and 1O2 played the dominant roles in the Fenton-like reaction. In combination with XPS, ESR and catalytic tests, it's found that the redox cycling of Cu+/Cu2+ played critical roles in accelerating the active radical generation in this Fenton-like system.

20.
J Clin Neurosci ; 65: 125-133, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31036506

RESUMO

The present study focused on the novel roles and the underlying mechanisms of miR-135b in pyroptosis of MPP+-induced Parkinson's disease (PD). We established an in vitro PD model induced by MPP+. Our results demonstrated miR-135b was lower while FoxO1 was inversely higher in MPP+-treated SH-SY5Y and PC-12 cells. Luciferase reporter assay showed FoxO1 was a downstream target of miR-135b. MiR-135b mimics suppressed MPP+-induced pyroptosis and the upregulation of TXNIP, NLRP3, Caspase-1, ASC, GSDMDNterm and IL-1ß. Moreover, FoxO1 overexpression had no effect on miR-135b but reversed its own downregulation caused by miR-135b mimics. Meanwhile, overexpression of FoxO1 abolished the inhibitory effects of miR-135b on pyroptosis and reversed the downregulation of pyroptotic genes and LDH release. In summary, miR-135b played a protective role in Parkinson's disease via inhibiting pyroptosis by targeting FoxO1. MiR-135b might serve as a potential therapeutic target in the treatment of Parkinson's disease.


Assuntos
Proteína Forkhead Box O1/metabolismo , Inflamassomos/metabolismo , MicroRNAs/genética , Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo , Doença de Parkinson/genética , Piroptose/genética , Proteínas de Transporte/metabolismo , Humanos , Proteínas de Neoplasias/genética , Regulação para Cima
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