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1.
Am J Clin Oncol ; 2020 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-32028340

RESUMO

OBJECTIVE: The authors conducted a cost-effectiveness analysis incorporating recent phase III clinical trial (IMpassion130) data to evaluate the cost-effectiveness of atezolizumab in combination with nab-paclitaxel (AnP) against nab-paclitaxel alone as the first-line treatment for advanced triple-negative breast cancer in developed and developing countries. MATERIALS AND METHODS: A decision-analytic Markov model was developed using IMpassion130 data to evaluate the cost-effectiveness of AnP over a lifetime from the US health care payer and Chinese health care system perspective. Model inputs were derived from IMpassion130 and published literature. The primary outcomes of the model were quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios (ICERs). Uncertainty was addressed using univariate and probabilistic sensitivity analyses. RESULTS: For the intention-to-treat (ITT) population, the projected mean outcome was better with AnP (1.41 QALYs) than with nab-paclitaxel alone (0.99 QALYs). Similar results were obtained for the programmed death ligand 1 (PD-L1)-positive population, with the obtained mean outcomes of 1.66 and 0.88 QALYs, respectively. For the Unites States, the ICER values comparing AnP with nab-paclitaxel were US$331,996.89 and US$229,359.88 per QALY gained for the ITT and PD-L1-positive populations, respectively. For China, the ICER values were US$106,339.26 and US$72,971.88 per QALY gained for the ITT and PD-L1-positive populations, respectively. The univariate sensitivity analysis indicated that the price of atezolizumab was the most influential factor in our study. AnP had 0% cost-effectiveness at the willingness-to-pay thresholds of US$150,000/QALY in the United States and US$29,383/QALY in China. CONCLUSION: AnP is not a cost-effective choice as the first-line treatment for advanced triple-negative breast cancer in the United States and China.

2.
Neurosci Lett ; 720: 134752, 2020 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-31927056

RESUMO

Event-related potential (ERP)-based brain-computer interface (BCI) has been widely used in robot control. Increasing the amplitude of the ERPs is key for improving the performance of ERP-based BCI. However, using images of robot motion as visual stimuli has not been studied widely. The aim of this study is to explore the concreteness of robot motion images on ERPs. Fifteen subjects used five kinds of visual spellers employing different images as visual stimuli: squares, arrows, a single kind of robot motion, multiple kinds of robot motions, and multiple kinds of robot motions with arrows. The three robot motion stimuli induced larger N200 and P300 potentials than non-robot motion stimuli. The topography shows that robot motion stimuli also evoke stronger negativities in the anterior and occipital areas. Concrete images provide more information to the subject about the robot motion, which might help the brain extract the meaning of the image more automatically. We use a support vector machine to detect the subject's intentions. There is substantial improvement in the classification performance when using robot motion images as visual stimuli, which implies that concrete visual stimuli improve the performance of the ERP-based BCI.

3.
Nat Commun ; 11(1): 265, 2020 01 14.
Artigo em Inglês | MEDLINE | ID: mdl-31937783

RESUMO

Glucose electrolysis offers a prospect of value-added glucaric acid synthesis and energy-saving hydrogen production from the biomass-based platform molecules. Here we report that nanostructured NiFe oxide (NiFeOx) and nitride (NiFeNx) catalysts, synthesized from NiFe layered double hydroxide nanosheet arrays on three-dimensional Ni foams, demonstrate a high activity and selectivity towards anodic glucose oxidation. The electrolytic cell assembled with these two catalysts can deliver 100 mA cm-2 at 1.39 V. A faradaic efficiency of 87% and glucaric acid yield of 83% are obtained from the glucose electrolysis, which takes place via a guluronic acid pathway evidenced by in-situ infrared spectroscopy. A rigorous process model combined with a techno-economic analysis shows that the electrochemical reduction of glucose produces glucaric acid at a 54% lower cost than the current chemical approach. This work suggests that glucose electrolysis is an energy-saving and cost-effective approach for H2 production and biomass valorization.

4.
Clin Drug Investig ; 40(2): 183-189, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31820329

RESUMO

BACKGROUND: Crizotinib, ceritinib, and alectinib improved survival in patients with anaplastic lymphoma kinase (ALK) arrangement non-small-cell lung cancer (NSCLC); however, the long-term economic outcomes of using ceritinib and alectinib versus crizotinib are still unclear. OBJECTIVE: This analysis aimed to evaluate the cost effectiveness of ceritinib and alectinib versus crizotinib in the Chinese healthcare setting. METHODS: A Markov model was developed to project the economic and health outcomes for the treatment of advanced NSCLC with ceritinib, alectinib or crizotinib. A network meta-analysis was performed to calculate the hazard ratios of ceritinib and alectinib versus crizotinib by pooling published trials. Cost and utility values were obtained from the literature, and one-way and probabilistic sensitivity analyses were carried out to determine the robustness of the model outcomes. The primary outputs included total cost, life-years (LYs), quality-adjusted LYs (QALYs), and incremental cost-effectiveness ratio (ICER). RESULTS: Treatment with alectinib and ceritinib yielded an additional 1.00 and 1.09 QALYs and incremental costs of $62,232 and $15,165, resulting in an ICER of $62,231 and $13,905 per QALY compared with crizotinib, respectively. Parameters related to drug costs and progression-free survival were the main drivers of the model outcomes. From the probabilistic sensitivity analysis, ceritinib and alectinib had a 99.9% and 0% probability of being cost effective, respectively, at a willingness-to-pay threshold of US$28,410/QALY. CONCLUSIONS: Our results indicate that compared with crizotinib and alectinib, ceritinib is a cost-effective option for treatment-naïve patients with ALK-positive advanced NSCLC.

5.
Sci Total Environ ; 675: 62-72, 2019 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-31026644

RESUMO

A new composite catalyst, i.e., Fe doped g-C3N4/graphite (Fe-CN/G), was successfully constructed to activate peroxymonosulfate (PMS) for efficient phenolic compounds (i.e., p-chlorophenol, 4-CP) degradation in the pH range of 3-10. The optimized Fe-CN/G, i.e., Fe3.75-CN/G5.0, was fabricated at the dosage of 3.75 mmol FeCl3·6H2O, 5.0 g dicyandiamide, and 5.0 mmol glucose. Fe complexed in the nitrogen pots of Fe3.75-CN/G5.0 was demonstrated to be the primary active site for PMS activation, and the introduction of graphite favored the exposure of more accessible active sites in Fe3.75-CN/G5.0, suggesting a synergistic effect between the Fe and graphite of Fe3.75-CN/G5.0 on 4-CP degradation. Multiple experiments confirmed that sulfate radical (SO4-), hydroxyl radical (HO), singlet oxygen (1O2) and superoxide radical (O2-) exerted negligible contribution on 4-CP degradation. The in-situ Fe K-edge X-ray absorption near-edge structure (XANEX) analysis revealed a redox cycle of Fe in PMS/Fe3.75-CN/G5.0, suggesting the formation of high-valent iron-oxo species (FeIVO) was responsible for 4-CP degradation. In addition, PMS/Fe3.75-CN/G5.0 exhibited acceptable degradation of 4-CP in the presence of coexisting anions and natural organic matters (NOM). We believe this study provides new insights into the design and development of Fe-based heterogeneous catalysts for PMS-based wastewater treatment.

6.
Biomed Rep ; 10(1): 23-28, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30588299

RESUMO

Tongue squamous cell carcinoma (TSCC) is the most common type of oral carcinoma. Mitochondrial DNA (mtDNA) is a circular DNA molecule of 16,569 bp, which functionally encompasses a regulatory non-coding region (D-loop) and 37 encoding genes that correspond to 13 subunits of respiratory chain complexes (I, III, IV and V), 22 transfer RNAs and 2 ribosomal (r)RNAs. Recently, mtDNA has been implicated as a mutation hotspot in various tumors. However, to our knowledge mtDNA alteration in TSCC has not been investigated to date. In the present study, the mitochondrial genomes of tongue carcinoma, adjacent non-cancerous tissue and peripheral blood samples from 8 patients with TSCC were sequenced and aligned with the revised Cambridge Reference Sequence. Overall, only one synonymous mutation, which mapped to the NADH:ubiquinone oxidoreductase core subunit 5 gene, was observed in the tongue carcinoma sample from a single patient. A further 21 polymorphisms were identified, including six in the non-coding region (D-loop), five in Complex I, three in Complex III, two in Complex IV, two in Complex V and three in rRNA. In addition, mitochondrial microsatellite instability (mtMSI) was detected in 2/8 tongue carcinoma samples, and localized in the D310 region. These variations, particularly the polymorphisms and mtMSI, imply that the mitochondrial genome may be a hotspot of genome alteration in tongue cancer. Further investigation is expected to reveal the role of mtDNA alteration in TSCC development, as well as its clinical implications.

7.
J Cell Biochem ; 2018 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-30390336

RESUMO

Glioblastoma (GBM) is a common and aggressive brain tumor that is associated with significant increase in glycolysis for energy production. Icaritin is a natural compound and exhibits anticancer activity in GBM. However, the effect of icaritin on glycolysis in GBM cells remains unclear. The aim of the current study was to investigate the effect of icaritin on glycolysis in GBM cells. The human GBM cell lines U87 and T98G were treated with icaritin or the inhibitor of Stat3 (S3I-201) in the presence or absence of recombinant human interleukin (IL)-6. Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay. The glycolysis was analyzed by detecting the glucose consumption and lactate production. The Western blot analysis was conducted to detect the expressions of hexokinase 2 (HK2), signal transducer and activator of transcription 3 (Stat3), p-Stat3, and B lymphoma Mo-MLV insertion region 1 (Bmi-1). Results showed that icaritin inhibited the viability of U87 and T98G cells in a dose-dependent manner. The decreased glucose consumption and lactate production, accompanied by reduced expressions of HK2, were found in both U87 and T98G cells. Icaritin inhibited the IL-6/Stat3 pathway, which is evidenced by the decreased expressions of p-Stat3 and Bmi-1. IL-6 treatment induced the phosphorylation of Stat3 and Bmi-1 expression, increased cell viability, as well as elevated glucose consumption, lactate production, and HK2 expression; however, the effects of IL-6 were attenuated by icaritin or S3I-201 treatment. In conclusion, icaritin exerted inhibitory effects on cell viability and glycolysis in GBM cells, which was mediated by the IL-6/Stat3 pathway.

8.
Water Res ; 147: 233-241, 2018 12 15.
Artigo em Inglês | MEDLINE | ID: mdl-30312796

RESUMO

Herein, we proposed a new catalytic oxidation system, i.e., iron(III)-tetraamidomacrocyclic ligand (FeIII-TAML) mediated activation of peroxymonosulfate (PMS), for highly efficient organic degradation using p-chlorophenol (4-CP) as a model one. PMS/FeIII-TAML is capable of degrading 4-CP completely in 9 min at the initial 4-CP of 50 µM and pH = 7, whereas the recently explored system, H2O2/FeIII-TAML, could only result in ∼22% 4-CP removal in 20 min under otherwise identical conditions. More attractively, inorganic anions (i.e., Cl-, SO42-, NO3-, and HCO3-) exhibited insignificant effect on 4-CP degradation, and the negative effect of natural organic matters (NOM) on the degradation of 4-CP in PMS/FeIII-TAML is much weaker than the sulfate radical-based oxidation process (PMS/Co2+). Combined with in-situ XANES spectra, UV-visible spectra, electron paramagnetic resonance (EPR) spectra, and radical quenching experiments, high-valent iron-oxo complex (FeIV(O)TAML) instead of singlet oxygen (1O2), superoxide radical (O2•-), sulfate radicals (SO4•-) and hydroxyl radicals (HO•) was the key active species responsible for 4-CP degradation. The formation rate (kI) and consumption rate (kII) of the FeIV(O)TAML in PMS/FeIII-TAML were pH-dependent in the range of 6.0-11.5. As expected, increasing the FeIII-TAML and PMS dosage resulted in a higher steady-state concentration of FeIV(O)TAML and enhanced the 4-CP degradation accordingly. In addition, the oxidation capacity of PMS was almost totally utilized in PMS/FeIII-TAML for 4-CP oxidation due to the two-electron abstraction from 4-CP by one PMS. We believe this study will shed new light on effective PMS activation by Fe-ligand complexes to efficiently degrade organic contaminants via nonradical pathway.


Assuntos
Poluentes Ambientais , Ferro , Peróxido de Hidrogênio , Peróxidos
9.
EBioMedicine ; 34: 231-242, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30077720

RESUMO

It has previously been reported that human adipose-derived stem cells (hASCs) can promote the regeneration of damaged tissues in rats with liver failure through a 'paracrine effect'. Here we demonstrate a therapeutic effect of hASCs derived Extracellular Vesicles (EVs) on rat models with acute liver failure, as shown by the improvement of the survival rate by >70% compared to controls. Gene sequencing of rat liver revealed an increase in human long-chain non-coding RNA (lncRNA) H19 after hASC-derived EVs transplantation. When the H19 coding sequence was silenced in hASCs and EVs were then collected for treatment of rats with liver failure, we saw a decrease in the survival rate to 40%, compared to treatment with EVs generated from non-silenced hASCs. These data indicate that lncRNA H19 may be a potential therapeutic target for the treatment of liver failure.


Assuntos
Vesículas Extracelulares/transplante , Falência Hepática Aguda/terapia , RNA Longo não Codificante/administração & dosagem , Tecido Adiposo/citologia , Animais , Humanos , Falência Hepática Aguda/metabolismo , Masculino , Ratos Sprague-Dawley , Regeneração , Células-Tronco/metabolismo
10.
Cell Physiol Biochem ; 48(4): 1710-1722, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30077997

RESUMO

BACKGROUND/AIMS: To evaluate whether local injection of exosomes derived from human adipose-derived stem cells (hADSCs) facilitates recovery of stress urinary incontinence (SUI) in a rat model. METHODS: For the in vitro study, a Cell Counting Kit-8 (CCK-8) array and proteomic analysis were performed. For the in vivo study, female rats were divided into four groups: sham, SUI, adipose-derived stem cell (ADSC), and exosomes (n = 12 each). The SUI model was generated by pudendal nerve transection and vaginal dilation. Vehicle, hADSCs, or exosomes were injected into the peripheral urethra. After 2, 4, and 8 weeks, the rats underwent cystometrography and leak point pressure (LPP) testing, and tissues were harvested for histochemical analyses. RESULTS: The CCK-8 experiment demonstrated that ADSC-derived exosomes could enhance the growth of skeletal muscle and Schwann cell lines in a dose-dependent manner. Proteomic analysis revealed that ADSC-derived exosomes contained various proteins of different signaling pathways. Some of these proteins are associated with the PI3K-Akt, Jak-STAT, and Wnt pathways, which are related to skeletal muscle and nerve regeneration and proliferation. In vivo experiments illustrated that rats of the exosome group had higher bladder capacity and LPP, and had more striated muscle fibers and peripheral nerve fibers in the urethra than rats of the SUI group. Both urethral function and histology of rats in the exosome group were slightly better than those in the ADSC group. CONCLUSIONS: Local injection of hADSC-derived exosomes improved functional and histological recovery after SUI.


Assuntos
Exossomos/metabolismo , Incontinência Urinária por Estresse/patologia , Tecido Adiposo/citologia , Animais , Proliferação de Células , Células Cultivadas , Exossomos/transplante , Feminino , Humanos , Músculo Esquelético/citologia , Músculo Esquelético/metabolismo , Músculo Esquelético/patologia , Cadeias Pesadas de Miosina/metabolismo , Proteoma/análise , Proteômica , Ratos , Ratos Sprague-Dawley , Células de Schwann/citologia , Células de Schwann/metabolismo , Transdução de Sinais/genética , Células-Tronco/citologia , Células-Tronco/metabolismo , Uretra/patologia , Incontinência Urinária por Estresse/terapia
11.
Small ; 14(34): e1801878, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30063288

RESUMO

The oxygen evolution reaction (OER) catalytic activity of a transition metal oxides/hydroxides based electrocatalyst is related to its pseudocapacitance at potentials lower than the OER standard potential. Thus, a well-defined pseudocapacitance could be a great supplement to boost OER. Herein, a highly pseudocapacitive Ni-Fe-Co hydroxides/N-doped carbon nanoplates (NiCoFe-NC)-based electrocatalyst is synthesized using a facile one-pot solvothermal approach. The NiCoFe-NC has a great pseudocapacitive performance with 1849 F g-1 specific capacitance and 31.5 Wh kg-1 energy density. This material also exhibits an excellent OER catalytic activity comparable to the benchmark RuO2 catalysts (an initiating overpotential of 160 mV and delivering 10 mA cm-2 current density at 250 mV, with a Tafel slope of 31 mV dec-1 ). The catalytic performance of the optimized NiCoFe-NC catalyst could keep 24 h. X-ray photoelectron spectroscopy, electrochemically active surface area, and other physicochemical and electrochemical analyses reveal that its great OER catalytic activity is ascribed to the Ni-Co hydroxides with modular 2-Dimensional layered structure, the synergistic interactions among the Fe(III) species and Ni, Co metal centers, and the improved hydrophily endowed by the incorporation of N-doped carbon hydrogel. This work might provide a useful and general strategy to design and synthesize high-performance metal (hydr)oxides OER electrocatalysts.

12.
Diabetes Metab Res Rev ; 34(8): e3053, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30064154

RESUMO

BACKGROUND: To identify the minimally important difference (MID) of the EQ-5D-3L and determinants of change in quality of life (QoL) as measured by the EQ-5D-3L over 1 year for Chinese type 2 diabetic patients (T2DPs). METHODS: Clinically diagnosed T2DPs were recruited from 66 community health centres in five Chinese cities using a multistage quota sampling method between December 2010 and October 2011. Demographics, diabetes-related information, and health-related behaviours were collected at baseline. The EQ-5D-3L was administered at baseline and at 12 months. Anchor-based and distribution-based approaches were employed to estimate MIDs. Using the MIDs as cut-points, we identified the change in EQ-5D-3L-measured QoL into "worsening," "no change," and "bettering." Logistic and ordered logistic regressions were conducted for those who reported best possible EQ-5D health state ("best possible HS") and impaired EQ-5D health states ("impaired HS") at baseline, respectively. Explanatory variables included demographics, diabetes-related information, and health-related behaviours. RESULTS: A total of 1958 patients (54.9% female, mean age 61.2 years, mean diabetes duration 7.9 years) were included in our analysis. MIDs of the EQ-5D-3L for deterioration and improvement were estimated as -0.066 to -0.003, and 0.049 to 0.077, respectively. For the impaired HS group, older age, lower education, and less exercise were significant predictors for worsening in QoL; whereas, those predictors were older age, female gender, and lower income for the best possible HS group. CONCLUSIONS: Minimally important differences for deterioration and improvement were estimated for the EQ-5D-3L. Age, gender, education, income, and exercise were significant determinants of QoL change for Chinese T2DPs.


Assuntos
Diabetes Mellitus Tipo 2/diagnóstico , Diabetes Mellitus Tipo 2/epidemiologia , Nível de Saúde , Qualidade de Vida , Idoso , China/epidemiologia , Feminino , Humanos , Individualidade , Masculino , Pessoa de Meia-Idade , Prognóstico , Fatores de Risco , Fatores Socioeconômicos , Inquéritos e Questionários
13.
Health Qual Life Outcomes ; 16(1): 78, 2018 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-29703205

RESUMO

BACKGROUND: The Diabetes Quality-of-Life (DQOL) Measure is a 46-item diabetes-specific quality of life instrument. The original English version of the DQOL has been translated into Chinese after cultural adaption, and the Chinese DQOL has been validated in the Chinese diabetic patient population and used in diabetes-related studies. There are two recognized problems with the Chinese DQOL: 1) the instrument is too long, and 2) the non-response rate of certain items is relatively high. This study aimed to develop and validate a short version for the Chinese DQOL. METHODS: Item reduction was conducted based on the classical test theory (CTT) and item response theory (IRT), each combined with exploratory factor analysis (EFA). The confirmatory factor analysis (CFA) and Spearman correlation coefficient were employed in validating the short versions. RESULTS: Both the study sample (n = 2,886) and the validation sample (n = 2,286) were from a longitudinal observation study of Chinese type 2 diabetic patients. The CTT kept 32 items, and the IRT kept 24 items from the original 46-item version. The two short versions were comparable in psychometric properties. CONCLUSION: The 24-item IRT-based short version of the Chinese DQOL was selected as the preferred short version because it imposes a lower burden on patients without compromising the psychometric properties of the instrument.


Assuntos
Diabetes Mellitus Tipo 2/psicologia , Qualidade de Vida , Inquéritos e Questionários/normas , Adulto , China , Análise Fatorial , Feminino , Humanos , Linguagem , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Psicometria , Traduções
14.
Environ Sci Technol ; 52(4): 2197-2205, 2018 02 20.
Artigo em Inglês | MEDLINE | ID: mdl-29373017

RESUMO

Herein, we proposed a new peroxymonosulfate (PMS) activation system employing the Fe(III) doped g-C3N4 (CNF) as catalyst. Quite different from traditional sulfate radical-based advanced oxidation processes (SR-AOPs), the PMS/CNF system was capable of selectively degrading phenolic compounds (e.g., p-chlorophenol, 4-CP) in a wide pH range (3-9) via nonradical pathway. The generated singlet oxygen (1O2) in the PMS/CNF3 (3.46 wt % Fe) system played negligible role in removing 4-CP, and high-valent iron-oxo species fixated in the nitrogen pots of g-C3N4 (≡FeV═O) was proposed as the dominant reactive species by using dimethyl sulfoxide as a probe compound. The mechanism was hypothesized that PMS was first bound to the Fe(III)-N moieties to generate ≡FeV═O, which effectively reacted with 4-CP via electron transfer. GC-MS analysis indicated that 4-chlorocatechol and 1,4-benzoquinone were the major intermediates, which could be further degraded to carboxylates. The kinetic results suggested that the formation of ≡FeV═O was proportional to the dosages of PMS and CNF3 under the experimental conditions. Also, the PMS/CNF3 system exhibited satisfactory removal of 4-CP in the presence of inorganic anions and natural organic matters. We believe that this study will provide a new routine for effective PMS activation by heterogeneous iron-complexed catalysts to efficiently degrade organic contaminants via nonradical pathway.


Assuntos
Compostos Férricos , Peróxidos , Ferro , Oxirredução
15.
Kidney Int ; 93(1): 245-251, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-28863945

RESUMO

Takayasu's arteritis is a rare systemic vasculitis mainly affecting the aorta and its major branches. Previous studies have suggested that almost half of the Asian Takayasu's patients have renal artery involvement. However, due to the rarity of the disease, little is known about renal artery involvement in Chinese Takayasu's arteritis patients. Here, we retrospectively reviewed and analyzed 411 patients diagnosed with Takayasu's arteritis in our center to explore the clinical features of renal artery involvement in this group of patients. Of these, 201 patients were diagnosed to have renal artery involvement, with stenosis (78.1%) the most common renal artery pattern. Compared to those without, patients with renal artery involvement were significantly younger at disease onset (23.5 vs 25.6 years) and more frequently had hypertension (74.6% vs 28.1%). Congestive heart failure (22.4% vs 7.6%) and pulmonary hypertension (19.9% vs 9.5%) were both significantly more prevalent among patients with than those without renal artery involvement. The estimated glomerular filtration rate (eGFR) significantly decreased as the severity of renal artery stenosis increased. Age at disease onset older than 24 years (odds ratio 6.06 [95% Confidence Interval 2.76-13.3]), disease duration longer than 19 months (3.35 [1.52-7.4]) and renal artery involvement (8.7 [3.8-20.1]) were independent risk factors for renal dysfunction (eGFR under 90 mL/min/1.73m2) among patients with Takayasu's arteritis. Thus, patients with renal artery involvement have more severe cardiac and renal dysfunction compared to those without. The eGFR is correlated negatively with the severity of renal artery stenosis.


Assuntos
Obstrução da Artéria Renal/epidemiologia , Artéria Renal/patologia , Arterite de Takayasu/epidemiologia , Adolescente , Adulto , China/epidemiologia , Feminino , Taxa de Filtração Glomerular , Insuficiência Cardíaca/epidemiologia , Humanos , Hipertensão Pulmonar/epidemiologia , Falência Renal Crônica/epidemiologia , Falência Renal Crônica/fisiopatologia , Masculino , Prevalência , Prognóstico , Artéria Renal/diagnóstico por imagem , Obstrução da Artéria Renal/patologia , Obstrução da Artéria Renal/fisiopatologia , Estudos Retrospectivos , Fatores de Risco , Índice de Gravidade de Doença , Arterite de Takayasu/patologia , Adulto Jovem
16.
Mitochondrial DNA A DNA Mapp Seq Anal ; 29(3): 347-352, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-28278694

RESUMO

Mitochondrial DNA (mtDNA) mutations played crucial roles on affecting the susceptibility to cancer. In this study, to investigate whether mitochondrial DNA mutations contributed to the genetic susceptibility of Chinese tongue cancer patients, mtDNA control regions of 105 Chinese tongue cancer patients were amplified and sequenced, the mutations were recorded by comparing with the revised Cambridge Reference Sequence (rCRS), which were attributed to certain mtDNA haplogroups based on the specific variations motif of each patients. The Miao Chinese group (a Chinese ethnic minority) from surrounding region has no essential difference with tongue cancer group, which was taken as the matched control group with principal component analysis by taking the haplogroups frequency of 105 tongue cancer individuals and 354 healthy individuals of eight groups from the similar geographic regions as input factors. This was supported by the smallest genetic distance between tongue cancer and Miao_2 groups. Further, the statistical analysis based on mtDNA variations of hypervariable sequence I (HVSI) indicated that 13 variations including 16,124, 16,148, 16,182C, 16,183C, 16,227, 16,266A, 16,249, 16,272, 16,291, 16,327, 16,335, 16,497, and 16,519 have significant differences between tongue cancer group and matched control group. Comparison of mtDNA haplogroups between tongue cancer and control groups indicated that mtDNA haplogroups C, F2*, and M10 have significant differences. It's worth noting that 16,327 and 16,291 was the defining variation of haplogroups C and F2*, respectively. Our results suggested that mitochondrial DNA may play a crucial role for the maternal genetic susceptibility of tongue cancer patients from Hunan, central of China.


Assuntos
Grupo com Ancestrais do Continente Asiático/genética , DNA Mitocondrial/genética , Análise de Sequência de DNA/métodos , Neoplasias da Língua/genética , Adulto , Idoso , Feminino , Estudos de Associação Genética , Predisposição Genética para Doença , Haplótipos , Humanos , Masculino , Herança Materna , Pessoa de Meia-Idade , Polimorfismo Genético , Análise de Componente Principal
17.
J Rheumatol ; 44(12): 1867-1874, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28811356

RESUMO

OBJECTIVE: To understand the characteristics of heart involvement in Chinese patients with Takayasu arteritis (TA). METHODS: The medical charts of 411 patients with TA (325 women, 86 men) were retrospectively reviewed. The comparison of clinical manifestations was carried out between the patients with TA with (n = 164) and without (n = 247) heart involvement. RESULTS: The median age at disease onset was 23.0 years (18.0-30.0) in 411 patients with TA, and 23.0 years (17.3-30.0) in 164 patients with heart involvement. The disease duration of the heart involvement group (median: 24.0 mos) was significantly longer than those patients without heart involvement (the control group, median: 16.0 mos). Hypertension (57.3% vs 46.6%; p = 0.033), renal dysfunction (17.1% vs 7.7%; p = 0.003), and bruit in the subclavian artery (45.1% vs 34.4%; p = 0.029) were more common in the heart involvement group than patients without. Valvular abnormalities were found in 134 (81.7%) patients in the heart involvement group, myocardial abnormalities in 26 (15.9%), and coronary artery abnormalities in 19 patients (11.6%). The age at onset (yrs) and disease duration (mos) of patients with myocardial, valvular, and coronary arterial abnormalities were 18.8/13.0, 23.8/23.5, and 26.8/57.0, respectively. In the heart involvement group, 22 patients (84.6%) with myocardial abnormalities, 15 (78.9%) with coronary arterial abnormalities, and 89 (66.4%) with valvular abnormalities had Numano type V vessel involvement. The level of high-sensitivity C-reactive protein was higher in the heart involvement group (median: 10.0 mg/l), and the difference was significant when compared to the control group (median: 7.0 mg/l; p = 0.017). CONCLUSION: Patients with TA complicated with cardiac abnormalities are not rare, especially in patients with Numano type V vessel involvement. We suggest that echocardiogram screening may be a helpful tool to understand the whole feature of patients with TA.


Assuntos
Cardiopatias/etiologia , Coração/fisiopatologia , Hipertensão/etiologia , Arterite de Takayasu/complicações , Adolescente , Adulto , China , Ecocardiografia , Feminino , Coração/diagnóstico por imagem , Cardiopatias/diagnóstico por imagem , Cardiopatias/fisiopatologia , Humanos , Hipertensão/diagnóstico por imagem , Hipertensão/fisiopatologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Avaliação de Sintomas , Arterite de Takayasu/diagnóstico por imagem , Arterite de Takayasu/fisiopatologia , Adulto Jovem
18.
Environ Sci Technol ; 51(11): 6326-6334, 2017 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-28499085

RESUMO

Water decontamination from As(III) is an urgent but still challenging task. Herein, we fabricated a bifunctional nanocomposite HFO@PS-Cl for highly efficient removal of As(III), with active chlorine covalently binding spherical polystyrene host for in situ oxidation of As(III) to As(V), and Fe(III) hydroxide (HFO) nanoparticles (NPs) embedded inside for specific As(V) removal. HFO@PS-Cl could work effectively in a wide pH range (5-9), and other substances like sulfate, chloride, bicarbonate, silicate, and humic acid exert insignificant effect on As(III) removal. As(III) sequestration is realized via two pathways, that is, oxidation to As(V) by the active chlorine followed by specific As(V) adsorption onto HFO NPs, and As(III) adsorption onto HFO NPs followed by oxidation to As(V). The exhausted HFO@PS-Cl could be refreshed for cyclic runs with insignificant capacity loss by the combined regeneration strategy, that is, alkaline solution to rinse the adsorbed As(V) and NaClO solution to renew the host oxidation capability. In addition, fixed-bed experiments demonstrated that the HFO@PS-Cl column could generate >1760 bed volume (BV) effluent from a synthetic As(III)-containing groundwater to meet the drinking water standard (<10 µg As/L), whereas other two HFO nanocomposites, HFO@PS-N and HFO@D201 could only generate 450 and 600 BV effluents under otherwise identical conditions.


Assuntos
Compostos Férricos , Nanocompostos , Poluentes Químicos da Água , Purificação da Água , Adsorção , Arsênico , Oxirredução , Polímeros , Água
19.
Chemosphere ; 175: 300-306, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28235738

RESUMO

As(III) preoxidation to As(V) is usually a requisite step for its efficient removal from water. Traditional oxidants reacting with As(III) homogenously in water suffer from the excessive dosage as well as the possible formation of disinfection byproducts. Herein, we developed a heterogeneous oxidant, i.e., a solid redox polymer (DOX), by covalently binding chlorine to a commercially available cation-exchange resin, D001. As(III) pre-oxidation by DOX is independent upon the solution pH (6-8) and ionic strength (0-0.1 M NaNO3). The presence of natural organic matters (NOMs) exhibits slightly adverse effect on the As(III) oxidation. More attractively, much less disinfection byproducts (DBPs, CHCl3 in this study) is formed during oxidation by DOX than by chlorine, possibly ascribed to the electrostatic repulsion between NOMs and DOX as well as the steric effect of the solid matrix. The exhausted DOX could be fully refreshed by the NaClO solution for cyclic use. The column oxidation experiment were performed by feeding the synthetic groundwater containing As(III), various minerals, and NOMs. It could result in As(III) decline from 200 × 10-3 mg/L initially to <1 × 10-3 mg/L with the working capacity of >33,200 bed volume (BV) even at the volumetric flow rate of 50 BV/h (i.e., EBCT = 1.2 min, equivalent to the linear velocity of 2.2 m/h). In summary, DOX is a highly efficient and environmental friendly oxidant for As(III) pre-oxidation in water treatment.


Assuntos
Arsênico/química , Cloro/química , Oxidantes/química , Polímeros/química , Poluentes Químicos da Água/química , Oxirredução , Purificação da Água/métodos
20.
Sci Rep ; 6: 36451, 2016 11 04.
Artigo em Inglês | MEDLINE | ID: mdl-27812031

RESUMO

Tungsten diselenide (WSe2) film was obtained by rapid selenization of magnetron sputtered tungsten (W) film. To prevent WSe2 film peeling off from the substrate during selenization, the W film was designed with a double-layer structure. The first layer was deposited at a high sputtering-gas pressure to form a loose structure, which can act as a buffer layer to release stresses caused by WSe2 growth. The second layer was deposited naturally on the first layer to react with selenium vapour in the next step. The effect of the W film deposition parameters(such as sputtering time, sputtering-gas pressure and substrate bias voltage)on the texture and surface morphology of the WSe2 film was studied. Shortening the sputtering time, increasing the sputtering-gas pressure or decreasing the substrate bias voltage can help synthesize WSe2 films with more platelets embedded vertically in the matrix. The stress state of the W film influences the WSe2 film texture. Based on the stress state of the W film, a model for growth of the WSe2 films with different textures was proposed. The insertion direction of the van der Waals gap is a key factor for the anisotropic formation of WSe2 film.

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