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1.
Food Chem ; 302: 125290, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31404873

RESUMO

In our daily lives, we consume foods that have been transported, stored, prepared, cooked, or otherwise processed by ourselves or others. Food storage and preparation have drastic effects on the chemical composition of foods. Untargeted mass spectrometry analysis of food samples has the potential to increase our chemical understanding of these processes by detecting a broad spectrum of chemicals. We performed a time-based analysis of the chemical changes in foods during common preparations, such as fermentation, brewing, and ripening, using untargeted mass spectrometry and molecular networking. The data analysis workflow presented implements an approach to study changes in food chemistry that can reveal global alterations in chemical profiles, identify changes in abundance, as well as identify specific chemicals and their transformation products. The data generated in this study are publicly available, enabling the replication and re-analysis of these data in isolation, and serve as a baseline dataset for future investigations.


Assuntos
Bebidas/análise , Análise de Alimentos , Manipulação de Alimentos , Espectrometria de Massas , Metabolômica , Fermentação , Fluxo de Trabalho
2.
Food Chem ; 305: 125435, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-31494497

RESUMO

Soluble dietary fibre (SDF) of micronized and non-micronized powders of lotus root nodes were investigated based on its adsorption and activity inhibition of pancreatic lipase (PL) by using circular dichroism, fluorescence spectroscopy and modification. Results showed that SDF2 (SDF from micronized powders of lotus root nodes) had stronger PL adsorption and enzyme activity inhibition than SDF1 (SDF from non-micronized powders of lotus root nodes). Specifically, SDF2 showed more binding sites than SDF1 in PL. There were hydrogen bonds and van der Waals interactions between SDF and PL, with Trp on PL probably serving as the main binding site. Carboxyl groups exhibited a stronger inhibition on PL by carboxymethyl and hydroxypropyl modification. The common mechanisms between SDF1 and SDF2 can be attributed to the combination between Trp and carboxyl groups, while the differences may be generated by the variations in structures or chemical groups induced by micronization.

3.
J Pharm Biomed Anal ; 177: 112868, 2020 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-31539713

RESUMO

Traditional Chinese Medicine Injection (TCMI) was restricted due to the batch-to-batch variability caused by the variable compositions of botanical raw materials and complexities of the current manufacturing process. To evaluate and control the quality of Kudiezi Injection (KDZI), a comprehensive and practical method based on multidimensional chromatographic fingerprint associated with multivariate statistical analysis was proposed. The multidimensional chromatographic fingerprint was established by integrating three kinds of chromatographic fingerprints, including High Performance Liquid Chromatography-Ultraviolet spectrum (HPLC-UV), Gas Chromatography-Mass Spectrometer (GC-MS) and High performance ion-exchange chromatography (HPIEC), which were used to detect flavones, nucleosides, organic acids, amino acids and saccharides in KDZI. In addition, four main multivariate statistical analyses were compared to assess the batch-to-batch consistency of samples. Results showed that the cosine method, which has been widely used in the quality evaluation of TCM, failed to distinguish the differences among batches based on neither chromatographic peaks' area nor contents information. t-test and Bayes' theorem could reveal the content difference among batches, while hierarchical clustering analysis could differentiate KDZI batches, and Luteolin-7-O-ß-D-glucuronopyranoside, Tau, Ser, guanine and allose were the main indicators. In conclusion, multidimensional chromatographic fingerprints could reflect the quality information of KDZI comprehensively and hierarchical clustering analysis was suitable to identify the differences among batches. This could provide an integrated method for consistency evaluation of TCMI, process improvement of TCMI and solving similar problems in TCMI.

4.
Comput Methods Programs Biomed ; 183: 105091, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31590098

RESUMO

BACKGROUND AND OBJECTIVE: The functional regions clustering through microelectrode recording (MER) is a critical step in deep brain stimulation (DBS) surgery. The localization of the optimal target highly relies on the neurosurgeon's empirical assessment of the neurophysiological signal. This work presents an unsupervised clustering algorithm to get the optimal cluster result of the functional regions along the electrode trajectory. METHODS: The dataset consists of the MERs obtained from the routine bilateral DBS for PD patients. Several features have been extracted from MER and divided into groups based on the type of neurophysiological signal. We selected single feature groups rather than all features as the input samples of each division of the divisive hierarchical clustering (DHC) algorithm. And the optimal cluster result has been achieved through a feature group combination selection (FGS) method based on genetic algorithm (GA). To measure the performance of this method, we compared the accuracy and validation indexes of three methods, including DHC only, DHC with GA-based FGS and DHC with GA-based feature selection (FS) in other studies, on the universal and DBS datasets. RESULTS: Results show that the DHC with GA-based FGS achieved the optimal cluster result compared with other methods. The three borders of the STN can be identified from the cluster result. The dorsoventral sizes of the STN and dorsal STN are 4.45 mm and 2.02 mm. In addition, the features extracted from the multiunit activity, background unit activity and local field potential are found to be the most representative feature groups to identify the dorsal, d-v and ventral borders of the STN, respectively. CONCLUSIONS: Our clustering algorithm showed a reliable performance of the automatic identification of functional regions in DBS. The findings can provide valuable assistance for both neurosurgeons and stereotactic surgical robots in DBS surgery.

5.
Anal Chim Acta ; 1094: 142-150, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31761041

RESUMO

α-synuclein is a predominantly expressing neuronal protein for understanding the neurodegenerative disorders. A diagnosing system with aggregated α-synuclein encoded by SNCA gene is necessary to make the precautionary treatment against Parkinson's disease (PD). Herein, gold-nanourchin conjugated anti-α-synuclein antibody was desired as the probe and seeded on single-walled carbon nanotube (SWCN) integrated interdigitated electrode (IDE). The surface morphology of SWCN-modified IDE and gold urchin-antibody conjugates were observed under FESEM, FETEM and AFM, the existing elements were confirmed. Voltammetry analysis revealed that the limit of fibril-formed α-synuclein detection was improved by 1000 folds (1 fM) with gold-nanourchin-antibody modified surface, compared to the surface with only antibody (1 pM). Validating the interaction of α-synuclein by Enzyme-linked Immunosorbent Assay was displayed the detection limit as 10 pM. IDE has a good reproducibility and a higher selectivity on α-synuclein as evidenced by the interactive analysis with the control proteins, PARK1 and DJ-1.

6.
Bioorg Med Chem Lett ; 30(1): 126781, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31706669

RESUMO

In this article, a new compound H2[{Cu(HL)(H2O)}2(P2Mo5O23)]·5H2O (1) (HL = 2-acetylpyrazine thiosemicarbazone) has been synthesized and structurally characterized by single-crystal X-ray diffraction of and other detection techniques. Interestingly, the structure of 1 is different from many reported copper-based complexes, in which the [P2Mo5O23]6-, two Cu2+ ions and two HL were directly connected by covalent bands. Biological studies demonstrated that 1 indicated moderate antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), and a better cytotoxicity against human hepatic cancer line (SMMC-7721) than Mitoxantrone (Mito), the current clinical anticancer drug. Besides, the antibacterial mechanisms of 1 have been studied by the membrane integrity disruption, the destructive reactive oxygen species generation (ROS), the glutathione (GSH) depletion and the depressed enzymatic activity of respiratory chain dehydrogenases (RCD). These results revealed that the combination of HL, Cu2+, [P2Mo5O23]6- shows a higher antibacterial and cytotoxic activity.

7.
Microvasc Res ; 127: 103923, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31494123

RESUMO

Minimally modified low-density lipoprotein (mmLDL) is a risk factor for cardiovascular disease. This study was designed to investigate the effect of a Toll-like receptor 4 monoclonal antibody (TLR4 mAb) on mmLDL-induced endothelium-dependent vasodilation (EDV) impairment in mouse mesenteric arteries and to explore the underlying mechanism. Animals were divided into a normal control group, an mmLDL treatment group, and a TLR4 mAb intervention group. The serum concentrations of IL-1ß and TNF-α were detected using enzyme-linked immunosorbent assays (ELISAs). EDV function was measured using a microvascular tension tracing method. The protein levels and mRNA expression of IL-1ß and TNF-α in vascular tissue were detected using western blot analysis and reverse transcription polymerase chain reaction, respectively. TLR4 mAb improved mmLDL-induced EDV functional impairment in a dose-dependent manner. TLR4 mAb significantly upregulated KCa3.1 and KCa2.3 channel protein levels and downregulated TNF-α and IL-1ß expression. These effects were possibly associated with the competitive antagonism of TLR4 mAb on the TLR4 signaling pathway and the downstream NF-κB p65 and p38 MAPK pathways, which are activated by mmLDL. In conclusion, pretreatment with TLR4 mAb lessens mmLDL-induced EDV dysfunction and inhibits overexpression of inflammatory factors. Regulation of the TLR4 pathway, as well as its downstream NF-κB p65 and p38 MAPK pathways, may be an effective strategy for the prevention and treatment of cardiovascular diseases.

8.
J Cell Physiol ; 235(1): 429-441, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31230364

RESUMO

Colorectal cancer (CRC) is still a fatal health problem around the world. The underlying mechanisms of CRC have not been fully elucidated. N-myc interactor (NMI) acts as an oncogene or a tumor-suppressor gene in several kinds of cancers but CRC. Here, the expression of NMI was found higher in CRC tissues and cells. Higher expression of NMI indicated the poorer prognosis of CRC patients. Moreover, the proliferation of CRC cells was suppressed significantly after we silenced the expression of NMI, while overexpression of NMI promoted CRC cell proliferation. Flow cytometry demonstrated that NMI promoted cell proliferation through facilitating cell transition from the G1 phase to the S phase. Furthermore, it was found that NMI suppressed the phosphorylation of Smad3 by upregulating the expression of STAT1. The effect of NMI depletion on cell proliferation could be reversed by using Smad3 inhibitor SIS3. In summary, our findings demonstrated that NMI promoted cell proliferation via TGFß/Smad pathway and could indicate the prognosis of patients with CRC.

9.
J Phys Condens Matter ; 32(5): 055503, 2020 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-31618718

RESUMO

Several layered transition metal borides can now be realized by a simple and general fabrication method (Fokwa et al 2018 Adv. Mater. 30 1704181), inspiring our interest to transition metal borides monolayer. Herein, we predict a new two-dimensional (2D) transition metal diboride MoB2 monolayer (ML) and study its intrinsic mechanical, thermal, electronic, and transport properties. The MoB2 ML has isotropic mechanic properties along the zigzag and armchair directions with a large Young's stiffness, and has an ultralow room-temperature thermal conductivity. The Mo atoms dominate the metallic nature of MoB2 ML. It shows an obvious electrical anisotropy and a current-limiting behavior. Our findings suggest that MoB2 ML is a promising multifunctional material used in ultrathin high-strength mechanical materials, heat insulating materials, electrical-anisotropy-based materials, and current limiters. It is helpful for the experimentalists to further prepare and utilize the transition metal diboride 2D materials.

10.
J Nanosci Nanotechnol ; 20(4): 2267-2276, 2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-31492236

RESUMO

Two-dimensional (2D) BiOBr nanosheets (NSs) have attracted considerable interest as photocatalysts. The surface active sites of BiOBr NSs are crucial in determining the photocatalytic performance of these materials under visible light. The modification of the surface state of BiOBr NSs with multiple charged groups has been scarcely studied as a way to increase the number of surface active sites and the corresponding photocatalytic activity. Herein, vanadate-rich 2D BiOBr/Bi NSs were in-situ fabricated without adding strong reductants and subsequently used for visible-light-driven photocatalysis. Even under reductant-free condition, we were able to simultaneously deposit Bi0 and vanadate groups on the surface of pristine BiOBr NSs. The corresponding formation mechanism was also explored in a subsequent step. Compared to pristine BiOBr NSs and BiOBr/Bi NSs, the vanadate-rich BiOBr/Bi NSs prepared herein exhibited superior adsorption and enhanced photodegradation of Rhodamine B (RhB) under visible light illumination.

11.
Biomed Pharmacother ; 122: 109686, 2019 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-31786464

RESUMO

Gastric cancer (GC) is one of the most common types of human cancers. However, the mechanisms underlying GC remained largely unclear. To determine whether the differentially expressed mRNAs, lncRNAs and circRNAs in GC, we screened conducted SBC-ceRNA microarray analysis in 3 pairs of GC and normal tissues. Furthermore, differentially expressed mRNAs mediated protein protein interaction (PPI) networks, lncRNAs mediated cis-regulatory network, and circRNA mediated ceRNA network were for the first time constructed to reveal their potential functions and mechanisms in GC. Quantitative real-time polymerase chain reaction analysis (qRT-PCR) was conducted to validate the microarray analysis. A total of 922 mRNAs, 2112 lncRNAs and 2896 circRNAs were observed to be dysregulated in GC samples. Bioinformatics analysis showed these differentially expressed genes (DEGs) were significantly associated with regulating branched - chain amino acid catabolic process, Glycolysis/Gluconeogenesis and ARF protein signal transduction. Moreover, we found the dysregulation of key mRNAs and lncRNAs were associated with the overall survival time in GC patients. We believe this study provides useful information for understanding the mechanism underlying GC progression and exploring potential therapeutic and prognostic targets for GC.

12.
Eur J Radiol ; 122: 108753, 2019 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-31794892

RESUMO

PURPOSE: To evaluate the diagnostic efficacy in differentiating metastatic from inflammatory perigastric lymph nodes (LNs) in patients with gastric cancer by using CT perfusion imaging (CTPI). METHOD: A total of 115 annotated perigastric LNs of 50 patients with gastric cancer confirmed by pathology underwent CTPI scan before operation. The scan data were postprocessed to acquire perfusion maps and parameters including blood flow (BF) and permeability surface (PS). A radiologist measured the short and long axis diameters, the short/long axis ratio and perfusion parameters of LNs. According to the post-operative pathology result, LNs were divided into two groups: metastatic and inflammatory nodes. Perfusion parameters and the size of LNs between two groups were respectively compared statistically, and a receiver-operating characteristic (ROC) curve analysis was used to determine the optimal diagnostic cutoff value with sensitivity, specificity and area under the curve (AUC). RESULTS: The mean values of perfusion parameters and the short/long axis diameters ratio in metastatic and inflammatory LNs, respectively, were BF of 91.64 vs. 79.35 ml/100 mg /min (p <  0.01), PS of 43.42 vs. 35.92 ml/100 mg /min (p <  0.01), and the size ratio of 0.75 vs. 0.68 (p <  0.01). The sensitivity of 85.3%, specificity of 66.0 % and AUC of 0.816 for BF with cutoff value of 80.76 ml/100 mg /min for differentiating metastatic from inflammatory nodes were higher than those of PS or the size of LNs (p < 0.05). CONCLUSIONS: BF may be a reliable diagnostic marker of metastatic perigastric LNs in gastric cancer.

13.
Analyst ; 2019 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-31799556

RESUMO

Striatal dopamine (DA) release plays an essential role in many physiological functions including motor and non-motor behaviors (such as reward, motivation, and cognition). We have previously reported that, following a single electrical field stimulation, the amperometric recording of DA release from presynaptic terminals in striatal slices (both ventral and dorsal) contains two temporally separated phases. The first phase (direct DA transmission, direct DT) arises from DA terminal release following autologous action potentials (APs), while the second phase (cholinergic transmission-induced DA transmission, CTDT) arises from delayed DA release triggered by the activation of cholinergic interneurons to DA terminals (axon-axon transmission). The millisecond time-resolution of amperometry permits separation of an ∼7 ms latency difference from the single synapse (axon-axon) within the two-phase DA-release (2pDA) signal, and thus the 2pDA signal provides a novel method to study either direct DT, or CTDT, or both. Here, we describe the 2pDA method, including signal recording, processing, analysis, and troubleshooting (anti-artifact). Compared with other DA assays using different stimuli, recording methods, and preparations (such as high performance liquid chromatography or fast scan cyclic voltammetry), 2pDA recording is a novel and powerful physiological recording method for the study of DA transmissions in situ.

14.
Artigo em Inglês | MEDLINE | ID: mdl-31799790

RESUMO

A rhodium-catalyzed remote C(sp3)-H borylation of silyl enol ethers (SEEs, E/Z mixtures) via alkene isomerization and hydroboration is reported. The reaction exhibits mild reaction conditions and excellent functional group tolerance. This method is compatible with an array of SEEs, including linear and branched SEEs derived from aldehyde and ketone, and provide direct access to a broad range of structurally diverse 1,n-borylethers in excellent regioselectivity and good yields, which are precursors to various valuable chemicals, such as 1,n-diols and aminoalcohols.

15.
Ecotoxicol Environ Saf ; : 109980, 2019 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-31785946

RESUMO

Artificial sweeteners (ASs) are applied widely as sucrose substitutes in food, pharmaceuticals, and personal-care products, which results in their release into surface water. The occurrence of ASs in aquatic environments in China has rarely been reported. In this study, we determined the concentration of seven ASs in surface water and sediment samples from 16 lakes in Wuhan. The sum of the ASs concentration ranged from 0.89 to 20.6 µg/L in the surface water, with a mean value of 4.96 ± 5.16 µg/L. The most abundant AS was sucralose (SUC), with a concentration from 0.33 to 18.0 µg/L, followed by acesulfame (ACE) (0.40-2.78 µg/L), saccharin (SAC) (

16.
Int Urol Nephrol ; 2019 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-31786703

RESUMO

PURPOSE: This study aimed at exploring whether the time interval (TI) between prostate biopsy and surgery affect the outcomes of radical prostatectomy (RP). METHODS: A comprehensive search of the PubMed, Embase, and Cochrane Library databases was conducted to identify all eligible studies. After quality assessment and date extraction, a systematic review and meta-analysis was performed. RESULTS: A total of 9 studies with 8579 patients were included in our meta-analysis. Pooled data showed no significant differences between groups of TI ≤ 2 weeks and > 2 weeks in operative time, estimated blood loss, transfusion rate, bilateral nerve preservation, positively surgical margin, and complications. For comparison between TI ≤ 4 and > 4 weeks, shorter TI would be associated with significantly less estimated blood loss (p = 0.045) and lower rate of bilateral nerve preservation (p = 0.002). In addition, for TI ≤ 6 versus > 6 weeks, significantly less bilateral nerve preservation (p = 0.025) and more positive surgical margin (p = 0.020) could be found in the earlier surgery group. Sensitivity analysis indicated that TI had no impact on any outcomes of robot-assisted laparoscopic radical prostatectomy (RALP). CONCLUSIONS: As shorter TI was associated with lower rate of bilateral nerve preservation and higher rate of positive surgical margin, it would be better to perform RP with a TI of 4 or 6 weeks after biopsy. While for RALP, shorter TI did not have any impact on outcomes of RALP, It is feasible and safe to perform RALP within 2, 4, or 6 weeks.

17.
Aging (Albany NY) ; 112019 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-31789604

RESUMO

A subgroup of overweight/obese individuals, who had favorable metabolic profiles, was termed as metabolically healthy overweight/obese (MHO). Several studies suggested that MHO individuals were not at increased risk of cardiovascular disease and all-course mortality. However, whether MHO is associated with excess risk of Alzheimer's disease (AD) in elders remains unclear. To explore the risk of AD among MHO phenotype and investigate whether MHO associates with neurodegenerative biomarkers of AD, we assessed body mass index-metabolic status phenotypes of 1199 longitudinal elders from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort using the Adult Treatment Panel-III (ATP- III) criteria. MHO subjects were at a significantly decreased risk for AD (adjusted HR=0.73, 95% CI: 0.54-0.97) compared with metabolically healthy normal weight (MHNW) subjects. In multivariable linear regression models, the cross-sectional associations of MHO with cerebrospinal fluid (CSF) biomarkers, brain Aß load, and cortical structure were explored. MHO was positively correlated with CSF-Aß (ß=0.746, P=0.015), hippocampal volume (ß=0.181, P=0.011), and whole brain volume (ß=0.133, P=0.004). The MHO phenotype of the elder conferred a decreased risk of AD and its role may be driven by Aß.

18.
Artigo em Inglês | MEDLINE | ID: mdl-31784083

RESUMO

Interleukin-17 (IL-17) and interferon-γ (IFN-γ), two inflammatory cytokines, are present in cancerous liver tissues. IL-17 was recently identified as an oncogenic factor in hepatocellular carcinoma (HCC), but its underlying mechanisms are largely obscure. Here, we aimed to investigate the interaction between IL-17 and IFN-γ and its influence on HCC cell apoptosis and growth in vitro and in vivo. We found that the expression of IL-17, but not IFN-γ, was obviously increased in HCC tissues. Higher IL-17 expression in tumor tissues correlated with shorter survival times. IFN-γ apparently increased apoptosis of HCC cells. IL-17 alone had no effect on apoptosis of HCC cells but reversed apoptosis induced by IFN-γ. IFN-γ mildly promoted the expression of protein inhibitor of activated signal transducer and activators of transcription 1 (PIAS1) and the activation of NF-κB, and these effects were greatly enhanced when combined with IL-17. PIAS1 silencing not only further amplified apoptosis induced by IFN-γ alone but also abolished the inhibitory effects of IL-17 on IFN-γ-induced apoptosis in HCC cells. An NF-κB inhibitor obviously decreased the upregulated expression of PIAS1 induced by IFN-γ plus IL-17 and IFN-γ alone. IFN-γ treatment retarded the tumor growth of HCC cells in an in vivo xenograft tumor model, which could be largely inhibited by combined treatment with IL-17. In conclusion, IL-17 obviously inhibits the antitumor effects of IFN-γ in hepatoma cells and, in turn, accelerates HCC development through upregulating the expression of the negative feedback regulator PIAS1 of the JAK/STAT1 pathway via enhancing activation of NF-κB.

19.
Cell Death Dis ; 10(12): 921, 2019 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-31801950

RESUMO

Bone loss in postmenopausal osteoporosis is induced chiefly by an imbalance of bone-forming osteoblasts and bone-resorbing osteoclasts. Salubrinal is a synthetic compound that inhibits de-phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α). Phosphorylation of eIF2α alleviates endoplasmic reticulum (ER) stress, which may activate autophagy. We hypothesized that eIF2α signaling regulates bone homeostasis by promoting autophagy in osteoblasts and inhibiting osteoclast development. To test the hypothesis, we employed salubrinal to elevate the phosphorylation of eIF2α in an ovariectomized (OVX) mouse model and cell cultures. In the OVX model, salubrinal prevented abnormal expansion of rough ER and decreased the number of acidic vesiculars. It regulated ER stress-associated signaling molecules such as Bip, p-eIF2α, ATF4 and CHOP, and promoted autophagy of osteoblasts via regulation of eIF2α, Atg7, LC3, and p62. Salubrinal markedly alleviated OVX-induced symptoms such as reduction of bone mineral density and bone volume fraction. In primary bone-marrow-derived cells, salubrinal increased the differentiation of osteoblasts, and decreased the formation of osteoclasts by inhibiting nuclear factor of activated T-cells cytoplasmic 1 (NFATc1). Live cell imaging and RNA interference demonstrated that suppression of osteoclastogenesis is in part mediated by Rac1 GTPase. Collectively, this study demonstrates that ER stress-autophagy axis plays an important role in OVX mice. Bone-forming osteoblasts are restored by maintaining phosphorylation of eIF2α, and bone-resorbing osteoclasts are regulated by inhibiting NFATc1 and Rac1 GTPase.

20.
Mol Omics ; 2019 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-31802092

RESUMO

Drug response prediction in cancer cell lines is vital to discover new anticancer drugs. However, it's still a challenging task to accurately predict drug responses in cancer cell lines. In this study, we presented a novel computational approach, named as MSDRP (modular within and between score for drug response prediction), to predict drug responses in cell lines. The method is based on a constructed heterogeneous drug-cell line network with multiple information. Compared with other state-of-the-art methods, MSDRP acquired better predictive performance, and identified potential associations between drugs and cell lines, which have been confirmed by the published literature. The source code of MSDRP is freely available at https://github.com/shimingwang1994/MSDRP.git.

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