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1.
Zhonghua Yi Xue Za Zhi ; 99(41): 3266-3272, 2019 Nov 05.
Artigo em Chinês | MEDLINE | ID: mdl-31694124

RESUMO

Objective: To observe the difference of brain activity in patients with diarrhea-type irritable bowel syndrome (IBS-D) treated with pinaverium bromide (PB) combined with flupentixol-melitracen (FM), and to explore the mechanism of efficacy of combined with anxiolytic/antidepressant drugs in IBS-D patients at the central level, using resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Forty-eight patients with IBS-D, including 28 males, 20 females, mean age 22-48 (33±7) years, were selected from the Affiliated Hospital of Hangzhou Normal University from October 2015 to October 2018.All patients with IBS-D underwent rs-fMRI scans before and after receiving either PB (basic treatment group, n=16), PB combined with FM (combination therapy group, n=16), or no medication (no treatment group, n=16). Rs-fMRI regional homogeneity (ReHo) parameter among the three groups of patients were compared using One-way ANOVA analysis and post analysis.Partial correlation and mediation analyses were performed on ReHo values and the improvement of symptoms scores (gastrointestinal symptom rating scale(GSRS) and hospital anxiety/depression scale (HAD)) in the two medicated groups. Results: No significant differences in ReHo values were observed among the three groups before treatment. Compared with patients on no-medication, patients receiving either PB or PB-FM showed decreased ReHo in the striatum, insular lobe, medial prefrontal cortex (MPFC) and subcallosal gyrus, and increased ReHo in the occipital cortex. In particular, the combined treatment group showed more extensive decreased ReHo in the left thalamus and left temporal pole, and increased in the left precuneus. Compared with the basic treatment group, the combined treatment group showed decreased ReHo in the right putamen, right insula, right MPFC and subcallosal gyrus, and increased ReHo in the left precuneus. In addition, the combined treatment group demonstrated a positive correlation between ReHo values in the left thalamus and the improvement of HAD score (r=0.653, P=0.011) , and a negative correlation between ReHo values in left precuneus and the improvement of GSRS and HAD score (r=-0.771, P=0.001; r=-0.716, P=0.004). ReHo values in the left precuneus were observed to mediate between gastrointestinal symptoms and anxiety-depressive symptoms in the combined treatment group. Conclusions: The efficacy of PB combined with FM is superior to PB alone in the treatment of IBS. In addition to more extensive changes in pain-related brain areas, IBS-D patients treated with anxiolytic/antidepressant also show changes in default network and brain areas related to emotional regulation, and are associated with improvement in gastrointestinal symptoms, anxiety and depression.

2.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ; 54(10): 754-759, 2019 Oct 07.
Artigo em Chinês | MEDLINE | ID: mdl-31606988

RESUMO

Objective: To explore the correlation between sleep and laryngopharyngeal reflux disease by epidemiological approaches. Methods: From May 1, 2017 to April 30, 2018, data of age, gender, height, weight, smoking, alcohol consumption, constipation and high fat diet in patients in Otorhinolaryngology specialist clinic, the Eighth Medical Center, General Hospital of the Chinese PLA were retrospectively analyzed. Reflux Symptom Index (RSI), Pittsburgh Sleep Quality Index (PSQI) and Hospital Anxiety and Depression Scale (HADS)were filled. According to RSI scores, patients were divided into case group and control group. The differences of the above indicators between the two groups were compared by Stata 12.0 software, and the risk factors of LPRD were analyzed by multivariate Logistic regression. Results: A total of 908 patients were enrolled, including 166 in the case group and 742 in the control group. There was no significant difference in BMI, smoking, drinking, constipation and high fat diet between the two groups (all P>0.05). The PSQI, anxiety and depression score of the case group were higher than those of the control group. The anxiety and depression scores of the patients with sleep disorders in the case group were significantly higher than those of the normal sleepers (all P<0.05). RSI of the patients with sleep disorders was higher than that of the patients with normal sleep(9.5[4.0,16.0]vs. 5.0[1.0,10.0], Z=-6.07, P<0.001). Multivariate analysis showed that sleep disorder was the risk factors of LPRD (OR=2.59, 95%CI 1.75-3.84). Conclusions: Sleep disorder is related to the occurrence of LPRD. The association between LPRD and sleep disturbances is bidirectional. Sleep disorder may also be related to the anxiety and depression in LPRD patients. Handling sleep disorder timely may benefit LPRD patients.

3.
Zhonghua Yi Xue Za Zhi ; 99(37): 2903-2906, 2019 Oct 08.
Artigo em Chinês | MEDLINE | ID: mdl-31607018

RESUMO

Objective: To analyze and summarize the clinical-pathological features of dermatosis papulosa nigra of Han Chinese people. Methods: We collected 71 cases of dermatosis papulosa nigra in the Third people's Hospital of Hangzhou Affiliated to Zhejiang Chinese Medical University of Department of Dermatology from January 2010 to January 2019 which were confirmed clinically and pathologically. The clinical and histopathological data of all patients were analyzed and summarized, and relevant literature were reviewed. Results: Among the 71 patients, 51 were female and 25 were male, their average age was (44±13) years, the average age of onset was (39±14) years, and the average time of diagnosis was (65±51) months. The lesions were multiple dark brown papules with smooth surface, and mostly distributed in the chest and abdomen, 46 cases (64.8%), followed by the back and neck. The mean diameter of the lesions was (1.76±0.99) mm. Meanwhile, the initial onset of pruritus was observed in 15 patients. The pathological features of all lesions were similar to seborrheic keratosis. According to pathological classification, there were 49 (69.0%) cases of the acanthotic type, 11(15.5%) cases of the hyperkeratotic type, 6 (8.5%) cases of spiroid type, 4 (5.6%) cases of irritated type, and 1 (1.4%) case of clonal type. Epidermal pigmentation and/or dermal papillary pigmented granules were observed in 56 cases (78.9%), of which 46 cases (64.8%) had basal layer pigmentation. In addition, inflammatory cell infiltration was found in the superficial dermis of lesions of 10 patients (14.1%) with symptom of itching. Conclusion: Dermatosis papulosa nigra of Han Chinese people has some unique clinical and pathological features.

4.
Zhonghua Liu Xing Bing Xue Za Zhi ; 40(10): 1173-1179, 2019 Oct 10.
Artigo em Chinês | MEDLINE | ID: mdl-31658512

RESUMO

Epidemiology is a discipline developed in the practice of preventing diseases and promoting health and is the key of public health and preventive medicine. Since the founding of the People's Republic of China, with the changing of disease pattern in populations, the applications of epidemiology now have expanded from infectious diseases to chronic non-communicable diseases, injuries and health related events. The discipline has made remarkable achievements in the field of disease prevention and control, scientific research and teaching, institution building and academic journals. In this paper we briefly review the history and achievements of epidemiology in China in the past 70 years, and explore the future development of the discipline, which may leave a trace of history for the development of epidemiology in China.


Assuntos
Doenças Transmissíveis , Epidemiologia/história , Saúde Pública , China , Assistência à Saúde , História do Século XX , História do Século XXI , Humanos
5.
Beijing Da Xue Xue Bao Yi Xue Ban ; 51(5): 964-967, 2019 Oct 18.
Artigo em Chinês | MEDLINE | ID: mdl-31624407

RESUMO

OBJECTIVE: To analyze the influence of different mixing pads on the physical and mechanical properties of glass ionomer cement. METHODS: Three different glass ionomer base cements were mixed with a plastic spatula on three different mixing pads including paper pad, glass pad and silicon pad whose HS were 40, 60 and 80. The GIC was packed into stainless steel molds to get specimens. Surface roughness, surface hardness and compressive strength were evaluated. RESULTS: As for compressive strength, CF: There was the highest mean compressive strength that was significantly higher than those of silicon pad 60 group, paper 60 group and paper 20 group in silicon pad 40 group, the differences P values were 0.002, 0.027, and 0.036, statistically significant difference between the above groups (P<0.05). IX: there was the highest mean compressive strength that was significantly higher than those of silicon pad 60 group in paper pad 20 group,the differences P value was 0.008, statistically significant (P<0.05). FX: there was the highest mean compressive strength that was no significantly higher than those of paper pad 20 group in silicon pad 40 group, but was significantly higher than those of the other groups. As for surface hardness, CF: there was the highest mean surface hardness that was significantly higher than those of silicon pad 60 and 80 group, paper 60 group in silicon pad 40 group, the differences P value was 0.021, 0.001, 0.032, 0.008 and 0.016, statistically significant difference between the above groups (P<0.05). IX and FX: there was no statistical significance between any two groups in surface hardness. As for surface roughness, CF: there was no statistical significance between any two groups in surface roughness. IX: there was the lowest mean surface roughness that was significantly lower than those of paper pad 40 and 60 group in glass pad group, the differences P values were 0.003 and 0.027, statistically significant difference between the above groups (P<0.05). FX: there was the lowest mean surface roughness that was significantly lower than those of paper pad 60 group in glass pad group, the differences P value was 0.018, showing a statistical difference (P<0.05). CONCLUSION: Mixing glass ionomer cement on silicon pad 40 results in higher compressive strength and lower surface roughness, worthy of clinical popularization.


Assuntos
Cimentos de Ionômeros de Vidro , Força Compressiva , Dureza , Teste de Materiais , Propriedades de Superfície
7.
Climacteric ; : 1-8, 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31612731

RESUMO

Background: The aim of this study was to examine the relationship between low bone mass and the risk of carotid calcification plaques in Chinese postmenopausal women. Methods: We conducted a 5 years prospective study. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) scanning. Carotid computed tomography angiography (CTA) was conducted using a 64-multidetector row scanner to assess carotid arterial plaque at baseline and during follow-up. Cox proportional hazards analysis was used to evaluate the association of BMD and risk of carotid calcification plaques. Results: Four hundred and eighty-eight women sustained prospective carotid plaques during the follow-up. Women with carotid calcification plaques had low BMD than those with carotid non-calcification plaques. After adjustment for potential confounders, BMD, age, years since menopause, levels of plasma osteoprotegerin and adiponectin, hypertension, diabetes mellitus and hyperlipidemia were independently associated with increased risk of carotid calcification plaques. For carotid calcification plaques, a significant inverse correlation was indicated between BMD and the plaques, and a significant positive correlation was indicated between bone loss and plaques. Conclusions: This study suggested that lower BMD and increased loss rate of BMD were associated with a higher risk of carotid calcification plaques in Chinese postmenopausal women.

8.
Acta Gastroenterol Belg ; 82(3): 355-358, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31566321

RESUMO

OBJECTIVE: To evaluate the safety and efficacy of endoscopic submucosal multi-tunnel dissection (ESMTD) for early esophageal cancer lesions larger than 3 cm in diameter or cumulatively greater than 1/2 lumen size. METHOD: Early esophageal cancer lesions in 15 patients were detected by endoscopy and endoscopic ultrasonography in our endoscopy center from December 2012 to June 2015. All lesions were successfully resected by ESMTD and diagnosed by pathology, and therapeutic efficiency and safety were followed after surgery. RESULTS: All 15 of the early esophageal cancer lesions were resected by ESMTD. The pathological results showed 9 moderately differentiated and 6 highly differentiated squamous cell carcinomas. En bloc resection was achieved in 13 lesions, with negative lateral and basal margins on pathology, whereas the other 2 required additional surgery. The average diameter of the resected lesions was 4.2±0.9 cm. The mean procedure time was 94.7±52.9 min. Esophageal stenosis was observed in 7 patients for whom esophageal water balloon dilatation was performed. No residual or recurrent lesion was found during the 6-36-month follow-up period. CONCLUSION: ESMTD is a safe and efficient technique for treating large early esophageal cancer lesions. Grasping the key techniques of this procedure can reduce operating difficulty and shorten the operating time.


Assuntos
Carcinoma de Células Escamosas/cirurgia , Ressecção Endoscópica de Mucosa/métodos , Endossonografia/métodos , Neoplasias Esofágicas/cirurgia , Estenose Esofágica , Esofagoscopia , Humanos
9.
Zhonghua Yi Xue Za Zhi ; 99(39): 3089-3092, 2019 Oct 22.
Artigo em Chinês | MEDLINE | ID: mdl-31648453

RESUMO

Objective: To evaluate the clinical values of 4 types of ceramides (Cer1, Cer2, Cer3, Cer4) in the coronary artery stenosis, clinical diagnosis and risk prediction. Methods: A total of 890 patients with coronary heart disease (CHD) in Beijing Anzhen Hospital between March 2018 and August 2018 were enrolled. The relationships between different degrees of coronary artery stenosis and ceramide levels was investigated. Diagnostic value of ceramides on acute myocardial infarction was analyzed. Meanwhile, Major adverse cardiac and cerebrovascular events (MACCE) in 1 year after discharging were collected to evaluate the predictive value of ceramides on risk of CHD and stroke. Results: This study showed that there were no significant differences of ceramide levels in CHD patients with different degrees of coronary artery stenosis (P>0.05), and the area under receiver operating characteristic (ROC) curve in the diagnosis of acute myocardial infarction patients was 0.725. Conclusions: Ceramide is proved to be helpful in the diagnosis of acute myocardial infarction and MACCE prediction. The relationships between ceramide and degrees of coronary artery stenosis as well as the prognosis of CHD need further elucidation.

10.
Zhonghua Yi Xue Za Zhi ; 99(39): 3093-3099, 2019 Oct 22.
Artigo em Chinês | MEDLINE | ID: mdl-31648454

RESUMO

Objective: To reconstruct a 3D model from adult femur CT scan data and automate a measurement of femoral anatomical parameters to study the characteristics of Chinese femur anatomical parameters. Methods: Using Mimics17.0, models from the CT data of 148 adult patients were established. The completed model was imported into Geomagic Studio and the anatomical landmarks of the femur were extracted to establish 3D coordinate system and unified coordinate system. Programmed with Matlab, using the nearest point iterative ICP algorithm and the 3D automatic extraction algorithm of anatomical landmarks to provide precision positioning, the femoral anatomical parameters were automatically measured and analyzed. The data were compared by using independent sample t test. Results: In this group, the diameter of the male femoral condyle was (84.1±3.6) mm, and it was (74.8±3.3) mm in the female; the anteroposterior diameter of the male femoral condyle was (66.5±3.7) mm, and it was (61.2±3.5) mm in the female; the diameter of the male ball head was (48.8±2.1) mm and it was (43.4±2.2) mm in the female; the differences between the two genders were all statistically significant (t=16.21, 8.84, 15.20, all P<0.05). The male femoral moment radius was (112.5±24.5) mm, and it was (124.7±19.2) mm in the female (t=3.30, P=0.002). The neck angle in male participants was 124.9°±4.0°, and it was 126.1°±5.5° in the female (t=1.40, P>0.05). As the height growed, most of the anatomical parameters increased accordingly. Conclusions: The 3D automatic measurement of femoral anatomical parameters is more reproducible and accurate than manual measurement. It is necessary to establish and enrich the femoral anatomical database to design and develop internal fixation products that meet the needs of Chinese people.

11.
Zhonghua Bing Li Xue Za Zhi ; 48(10): 802-804, 2019 Oct 08.
Artigo em Chinês | MEDLINE | ID: mdl-31594047
13.
Eur Rev Med Pharmacol Sci ; 23(18): 7935-7942, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31599418

RESUMO

OBJECTIVE: Nasopharyngeal carcinoma (NPC) is a polygenic hereditary disease, and the exact pathogenesis remains poorly understood. MiR-155 regulates the development and progression of several tumors. However, the role of MiR-155 in NPC has not been elucidated. PATIENTS AND METHODS: The NPC cell line CNE2 was cultured in vitro and divided into control group, miR-155 mimics group, and miR-155 inhibitor group, followed by analysis of miR-155 expression by real-time PCR, cell proliferation by MTT assay, cell invasion by transwell chamber, Caspase3 activity, apoptosis of CNE2 cells by flow cytometry, and the expression of PTEN-PI3K/AKT signaling pathway by Western blot. RESULTS: Transfection of miR-155 mimics significantly up-regulated miR-155 expression, promoted the proliferation and invasion of CNE2 cells, inhibited Caspase 3 activity, and decreased cell apoptosis, and PTEN expression, as well as increased PI3K/AKT phosphorylation, compared with control group (p < 0.05). Transfection of miR-155 inhibitor inhibited the proliferation and invasion of CNE2 cells, increased Caspase 3 activity, cell apoptosis, and PTEN expression, as well as reduced PI3K/AKT phosphorylation. Compared with control group, the differences were statistically significant (p < 0.05). CONCLUSIONS: Up-regulation of miR-155 can promote the proliferation of NPC cells and inhibit cell apoptosis by targeting the PTEN-PI3K/AKT pathway, thereby participating in the development and invasion of NPC, indicating that it might be a potential novel target for treating NPC.

14.
Zhonghua Gan Zang Bing Za Zhi ; 27(8): 653-656, 2019 Aug 20.
Artigo em Chinês | MEDLINE | ID: mdl-31594087

RESUMO

Abnormal liver function in pregnancy is a common clinical problem in the department of obstetrics and liver disease, but its severity can cause danger to the life of the mother and fetus. Therefore, the different cause of abnormal liver function in pregnancy should be assessed accurately in order to take early intervention measures. Moreover, it is necessary to comprehensively evaluate the situation of both mother and fetus to obtain the optimal treatment effect for abnormal liver function caused by different types of pregnancy-related liver diseases.


Assuntos
Hepatopatias/fisiopatologia , Complicações na Gravidez , Feminino , Humanos , Gravidez
15.
Artigo em Chinês | MEDLINE | ID: mdl-31623047

RESUMO

Objective:To analyze the relationship and mechanism of mast cell with allergic rhinitis and nasal polyps. Method:From January 2018 to June 2018, all the inpatients in Otolaryngology Department were examined by nasal endoscopy and CT before operation. They were divided into three groups: 30 patients with allergic rhinitis(AR group) and 30 patients with nasal polyps(NP group) as the experimental group; 30 patients with nasal septum correction after partial inferior turbinectomy alone as the control group(N group). Clinical data, peripheral blood and nasal mucosa were collected. The percentage of eosinophils in peripheral blood was detected by automatic hematology analyzer. The levels of anti-IgE antibody, FcεRIα and anti-FcεRIα antibody in serum were detected by ELISA. The levels of serum IgE were detected by velocity scattering turbidimetry. HE was used to observe the histopathological changes in the three groups. Immunohistochemical method was used to analyze the expression of tryptase and FcεRIα in the experimental group and the control group. Result:The percentage of eosinophils, IgE, anti-IgE antibody, FcεRIα and anti-FcεRIα antibodies in AR group were significantly higher than those in control group(P<0.05); the percentage of eosinophils, FcεRIα and anti-FcεRIα antibodies in NP group were significantly higher than those in healthy control group(P<0.05). There was no significant difference in IgE and anti-IgE antibodies among three groups(P>0.05). The eosinophil percentage, IgE and anti-IgE antibody levels in AR group were significantly higher than that in NP group(P<0.05); there were no differences in FcεRIα and anti-FcεRIα antibody levels between AR group and NP group(P>0.05); There was no significant difference in eosinophil infiltration between the two groups; The brown tryptase-positive mast cells and FcεRIα-positive mast cells were found in the submucosa and interstitium of nasal mucosa. Conclusion:The high expression of FcεRIα and its antibody in the serum of patients with allergic rhinitis and nasal polyps indicated that this antibody system was involved in the occurrence and development of allergic rhinitis and nasal polyps. Local allergy with mast cells as the core might play an important role in the occurrence and development of nasal polyps. The possible role of mast cells in the formation of nasal polyps and the specific mechanism deserve further study.


Assuntos
Mastócitos/metabolismo , Pólipos Nasais/metabolismo , Rinite Alérgica/metabolismo , Eosinófilos , Humanos , Imunoglobulina E , Mucosa Nasal
16.
Zhonghua Wai Ke Za Zhi ; 57(9): 660-665, 2019 Sep 01.
Artigo em Chinês | MEDLINE | ID: mdl-31474057

RESUMO

Objective: To summarize the experience of treatment for blunt pancreatic trauma. Methods: The clinical data of 52 patients with blunt pancreatic trauma admitted to the Department of Pancreatic and Biliary Surgery of the First Affiliated Hospital of Harbin Medical University from January 2013 to June 2018 were analyzed retrospectively.There were 40 male and 12 female patients, aging from 12 to 112 years with a median age of 35.5 years.According to the organ injury scale by American Association for the Surgery of Trauma(AAST) for pancreatic injury severity, 15 cases were in grade Ⅰ(28.8%), 20 cases were in grade Ⅱ(38.5%), 10 cases were in grade Ⅲ(19.2%),5 cases were in grade Ⅳ(9.6%) and 2 cases were in grade Ⅴ(3.8%). Isolated blunt pancreatic trauma occurred in 11(21.2%) patients including 5 cases of grade Ⅰ,5 cases of grade Ⅱ and 1 case of grade Ⅲ, and associated injuries existed in 41 patients(78.8%). Results: Among 52 patients, 36 patients(69.2%) were transferred from other hospitals and 16(30.8%) patients were admitted through the emergency department. Finally, 49 patients(94.2%) were cured and 3 patients (5.8%) died.For the 15 cases of grade Ⅰ,9 patients were managed non-operatively, 5 cases underwent peritoneal lavage and drainage after surgery for the other injured abdominal organs, and 1 patient received percutaneous catheter drainage(PCD) with non-operative treatment. For the 20 cases of grade Ⅱ,4 cases only received non-operative treatment and 2 cases also received PCD. Besides, 2 cases underwent debridement and drainage for peripancreatic necrotic tissue and external drainage for pancreatic pseudocyst retrospectively after about 25 days of getting injured. As for patients who received exploratory laparotomy, 5 patients underwent suture repair associated with external drainage, and 7 patients were managed only with external drainage. For the 10 cases of grade Ⅲ,6 patients were cured through distal pancreatectomy and splenectomy with external drainage, while 2 patients underwent endoscopic retrograde cholangiopancreatography and ductal stenting, and the other 2 patients just received debridement and drainage for peripancreatic necrotic tissue.For the 5 cases of grade Ⅳ,2 patients underwent jejunostomy and abdominal cavity drainage, 1 patient had a pancreaticoduodenectomy with drainage,1 patient received suture repair of the pancreas and pancreaticojejunostomy, and 1 patient was managed with suture repair of the head of pancreas and external drainage.For the 2 patients of grade Ⅴ,1 patient received exploratory laparotomy and gauze compression packing hemostasis, and the other patient underwent pancreaticoduodenal repair, gastrointestinal anastomosis, duodenal exclusion surgery and external drainage. Conclusion: According to the AAST classifications, associated injuries, physiological status and intraoperative situation, it could be better to make a comprehensive judgment, achieve early diagnosis and take appropriate individualized treatment strategy, and to improve the overall therapeutic effect for blunt pancreatic trauma.


Assuntos
Traumatismos Abdominais/terapia , Pâncreas/lesões , Traumatismos Abdominais/classificação , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pâncreas/cirurgia , Estudos Retrospectivos , Resultado do Tratamento , Ferimentos não Penetrantes/classificação , Ferimentos não Penetrantes/terapia , Adulto Jovem
17.
Br J Biomed Sci ; : 1-5, 2019 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-31532353

RESUMO

Objectives: Specific single-nucleotide polymorphisms (SNPs) in the M-type phospholipase A2 receptor-1 (PLA2R1) are associated with increased risk of idiopathic membranous nephropathy (IMN) in European populations. We hypothesized links between IMN and SMN with these SNPs in two Chinese cohorts. Methods: A cohort of 166 IMN patients and 144 controls from southern China (Group A) and a cohort of 212 IMN patients, 118 SMN patients, and 162 controls from northwestern China (Group B) were recruited. SNPs within PLA2R1 (rs3749119, rs3749117, rs35771982, rs3828323, and rs4664308) were identified and the frequencies of genotypes and alleles were determined for the different groups. Results: Relative to controls, IMN patients had a greater prevalence of rs35771982, rs3749117, and rs4664308 in Group A (OR = 1.61, 95% CI = 1.13-2.31, P = 0.011; OR = 1.62 (1.15-2.29), P = 0.006 and OR = 1.17 (1.06-1.28), P = 0.001, respectively) and in Group B (OR = 1.58 (1.13-2.22), P = 0.009; OR = 1.68 (1.22-2.33), P = 0.002 and OR = 1.15 (1.06-1.25), P < 0.001, respectively). Genotype and allele distributions of rs4664308 differed significantly between SMN patients and controls in Group B (OR = 1.58 (1.10-2.26), P = 0.012). Genotype and allele distribution of rs35771982 and rs4664308 differed significantly between PLA2R-Ab(+) and PLA2R-Ab(-) IMN patients in Group B (OR = 1.59 (1.09-2.31), P = 0.018 and OR = 1.15 (1.03-1.29), P = 0.005, respectively). Conclusion: This study of two cohorts from different regions of China indicate that specific PLA2R1 polymorphisms are associated with IMN and SMN.

18.
Opt Express ; 27(16): 23164-23172, 2019 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-31510599

RESUMO

We demonstrate a significant enhancement in the sensitivity of split ring resonator terahertz metamaterial dielectric sensors by the introduction of etched trenches into their inductive-capacitive gap area, both through finite element simulations and in experiments performed using terahertz time-domain spectroscopy. The enhanced sensitivity is demonstrated by observation of an increased frequency shift in response to overlaid dielectric material of thicknesses up to 18 µm deposited on to the sensor surface. We show that sensitivity to the dielectric is enhanced by a factor of up to ∼2.7 times by the incorporation of locally etched trenches with a depth of ∼3.4 µm, for example, and discuss the effect of the etching on the electrical properties of the sensors. Our experimental findings are in good agreement with simulations of the sensors obtained using finite element methods.

19.
Artigo em Inglês | MEDLINE | ID: mdl-31522917

RESUMO

To compare the effectiveness and safety of robotic surgery with that of open operations for patients with cancers of the head and neck we made an electronic search of the CENTRAL, MEDLINE, EMBASE, CNKI, CBM, Opengray and Sciencepaper Online databases, and then made a manual search of specific online databases and the reference lists of relevant papers. Our most recent searches were made on 18 July 2018, and we included randomised controlled trials (RCT), case-control studies, cohort studies, and cross-sectional surveys in which robotic was compared with open surgery for cancer of the head and neck. Data from all the studies included were extracted by two independent workers. The risk ratio was chosen to measure dichotomous effects of treatment for prospective studies including RCT or cohort studies, while the odds ratio was chosen for case-control or cross-sectional studies. The weighted mean difference or standard mean difference was chosen to summarise continuous effects. A random-effects model was used for all data analyses. Thirteen studies were included: one RCT, nine cohort studies, and three cross-sectional studies. Robotic surgery was associated with fewer invaded resection margins, lower recurrence, less need for intraoperative tracheostomy, and less need and shorter duration of postoperative nasal feeding than open operations. Robotic surgery is a safe and feasible approach with remarkable superiority over open surgery for the treatment of cancers of the head and neck.

20.
Zhonghua Wai Ke Za Zhi ; 57(10): 25-30, 2019 Oct 01.
Artigo em Chinês | MEDLINE | ID: mdl-31510729

RESUMO

Objective: To investigate the prognostic factors of multi-drug resistant organism (MDRO) infection in patients with infected pancreatic necrosis(IPN). Methods: A retrospective study was performed to assess the MDRO in IPN patients. The clinical data of 104 IPN patients admitted to the Department of Pancreatic and Biliary Surgery, the First Affiliated Hospital of Harbin Medical University from June 2013 to January 2019 were analyzed. Fifty-six patients were allocated in the MDRO group and 48 patients in the non-MDRO group depended on drug sensitivity test. There were 37 males and 19 females in the MDRO group with age of 40 (23) years. The duration time was 3(5) days between onset and admission. In the non-MDRO group,34 males and 14 females were included with age of (42±14)years. The duration time was 3(4) days between onset and admission. Normally distributed quantitative variables was represented by x±s, non-normally distributed quantitative variables was represented by M(Q(R)). Wilcoxon rank-sum test and χ(2) test were used to analyze the data. Univariate and multivariable Logistic regression analytic model were used to figure out the risk factors associated with MDRO infection. Results: The mean duration of hospital stay was 29.5(31.8) days and hospitalization expenses were CNY 166 991(270 692), which were much higher than those in non-MDRO group (16.5(15.7) days, 56 789(62 354) yuan) (W=1 889, 2 019, both P<0.01). Gram-negative isolates(67.2%, 80 /119) were commonly detected in IPN patients. Acinetobacter baumannii was the most common MDRO(27.0%,20/74). Initial use of carbapenem(OR=2.22, 95%CI: 1.02-4.96, P=0.047) and open necrosectomy(OR=10.00, 95%CI: 3.14-44.77, P<0.01) were the potential risk factors for MDRO-induced infections in IPN. Furthermore, the Logistic regression analysis revealed that open necrosectomy is the independent variable for MDRO infections (OR=9.42, 95%CI: 2.92-42.42, P<0.01). Conclusion: Open necrosectomy was the independent risk factor for the infection of MDRO.


Assuntos
Desbridamento/efeitos adversos , Farmacorresistência Bacteriana Múltipla , Infecções por Bactérias Gram-Negativas/etiologia , Pancreatite Necrosante Aguda/microbiologia , Adolescente , Adulto , Antibacterianos/uso terapêutico , Feminino , Infecções por Bactérias Gram-Negativas/microbiologia , Infecções por Bactérias Gram-Negativas/terapia , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Pancreatite Necrosante Aguda/cirurgia , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
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