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1.
Chemosphere ; 286(Pt 3): 131738, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34388437

RESUMO

The removal of toxic and harmful heavy metal contaminants from wastewater is of great importance for global environmental health. The development of efficient photocatalysts is attracting increasing interest with a current focus on material design for improved efficiency. Accordingly, this study aims to optimize the conformation of nanocomposite prepared from a CdS/ZnO heterojunction on reduced graphene oxide (RGO) for boosting the photocatalytic removal of heavy metal contaminants of aqueous systems. Under visible light, the candidate nanocomposites exhibited a range of photocatalytic activity in reducing hexavalent chromium [Cr(VI)] to trivalent chromium [Cr(III)] at room temperature. Among these different nanocomposites, the photocatalytic removal rate constant of Cr(VI) ranged as follows: ZnO/CdS6:5/RGO6 (0.106 min-1) > ZnO/CdS6:5 (0.0630 min-1) > CdS (0.0335 min-1) > ZnO (0.00121 min-1). Moreover, after five cycles of use, the photocatalytic reduction rate of ZnO/CdS6:5/RGO6 was 93.2 %, which signifies its strong re-cycling performance. These results reveal the feasibility of using CdS/ZnO6:5/RGO6 to reduce heavy metal ions from wastewater and provide insights for efficiently removing heavy metal ions without additional chemical trapping agents in the photocatalytic process.


Assuntos
Grafite , Óxido de Zinco , Cromo
2.
Front Oncol ; 11: 737497, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34745958

RESUMO

Hepatocellular carcinoma (HCC) is one of the most common malignant tumor in the world and its incidence is increasing in many countries. In recent years, with the deepening understanding of the immune and pathological mechanisms of HCC, immunotherapy based on the regulation of tumor immune microenvironment has become a new treatment choice for patients with HCC. Immune checkpoint inhibitors (ICIs) targeting programmed death protein-1, programmed death protein-ligand-1, or cytotoxic T-lymphocyte-associated antigen 4 are the most widely used. Instead of general immune-enhancing therapies, ICIs can reactivate anti-tumor immune responses by disrupting co-inhibitory T cell signaling. In this review, the research progress and existing problems of ICIs in the treatment of HCC in recent years are reviewed.

3.
J Healthc Eng ; 2021: 7296322, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34765103

RESUMO

The objective of this study was to evaluate the interrater and intrarater reliability of electrical impedance myography (EIM) using handheld sensors of different sizes. Electrical impedance myography of the biceps brachii muscle of twenty healthy individuals was performed by two raters using both large and small sensors. The procedures were also repeated 5 to 8 days after the first recording session. The repeatability of the resistance, reactance, and phase angle at two different current frequencies (50 and 100 kHz) was assessed by the intraclass correlation coefficient (ICC). The ICCs of the large sensor were higher than those of the small sensor for both the intrarater and interrater reliabilities. High-frequency current tended to improve the ICC for the small sensor. These results indicate reasonable repeatability of the handheld electrode arrays for EIM measurements. The findings suggest that electrode array should be selected appropriately according to the size of the tested muscle.

4.
Nanoscale ; 2021 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-34787622

RESUMO

New types of rechargeable batteries other than lithium-ions, including sodium/potassium/zinc/magnesium/calcium/aluminum-ion batteries and non-aqueous batteries, are rapidly advancing towards large-scale energy storage applications. A major challenge for these burgeoning batteries is the absence of appropriate electrode materials, which gravely hinders their further development. Expanded graphite (EG)-based electrode materials have been proposed for these emerging batteries due to their low cost, non-toxic, rich-layered structure and adjustable layer spacing. Here, we evaluate and summarize the application of EG-based materials in rechargeable batteries other than Li+ batteries, including alkaline ion (such as Na+, K+) storage and multivalent ion (such as Mg2+, Zn2+, Ca2+ and Al3+) storage batteries. Particularly, this article discusses the composite strategy and performance of EG-based materials, which enables them to function as an electrode in these emerging batteries. Future research areas in EG-based materials, from the fundamental understanding of material design and processing to reaction mechanisms and device performance optimization strategies, are being looked forward to.

5.
Artigo em Inglês | MEDLINE | ID: mdl-34811605

RESUMO

Product retention in hollow fibers is a common issue in ATF-based cell culture system. In this study, the effects of four major process factors on product (therapeutic antibody/recombinant protein) retention were investigated using Chinese hamster ovary cell. Hollow fibers made of polysulfone presented a product retention rate from 15% ± 8 to 43% ± 18% higher than those made of polyether sulfone varying with specific processes. Higher harvest flowrate and ATF exchange rate increased product retention by 13% ± 10% and up to 31% ± 13%, respectively. Hollow fibers with larger pore sizes (0.65 µm) appeared to have increased product retention by 38% ± 7% compared with smaller ones (0.2 µm) in this study. Further investigation revealed that the effects of pore size on retention could be correlated to the particle size distribution in the cell culture broth. A hollow fiber with a larger pore size (>0.5 µm) may reduce protein retention when small particles (approximately 0.01-0.2 µm in diameter) are dominant in the culture. However, if majority of the particles are larger than 0.2 µm in diameter, hollow fiber with smaller pore sizes (0.2 µm) could be a solution to reducing product retention. Alternatively, process optimization may modulate particle size distribution towards reduced production retention with selected ATF hollow fibers. This study for the first time highlights the importance of matching proper pore sizes of hollow fibers with the cell culture particles distribution and offers methods to reducing product retention and ATF column clogging in perfusion cell cultures. KEY POINTS: The material of ATF column could impact product retention during perfusion culture. Higher harvest flowrate and ATF exchange rate increased product retention. Matching culture particle size and ATF pore size is critical for retention modulation.

6.
Entropy (Basel) ; 23(11)2021 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-34828234

RESUMO

When confronted with massive data streams, summarizing data with dimension reduction methods such as PCA raises theoretical and algorithmic pitfalls. A principal curve acts as a nonlinear generalization of PCA, and the present paper proposes a novel algorithm to automatically and sequentially learn principal curves from data streams. We show that our procedure is supported by regret bounds with optimal sublinear remainder terms. A greedy local search implementation (called slpc, for sequential learning principal curves) that incorporates both sleeping experts and multi-armed bandit ingredients is presented, along with its regret computation and performance on synthetic and real-life data.

7.
J Basic Microbiol ; 2021 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-34738230

RESUMO

Various mechanisms are involved in plant disease resistance mediated by entomopathogenic fungi; however, the role of plant endophytic microbes in disease resistance is unknown. In the present study, we showed that the disease incidence of northern corn leaf blight caused by Exserohilum turcicum (Et) on maize was reduced significantly by soil inoculation with Beauveria bassiana (Bb). Meanwhile, B. bassiana colonization and E. turcicum infection increased the diversity and abundance and diversity of endophytic bacteria and fungi, respectively, while the abundance of endophytic bacterial of the Bb + Et treatment decreased significantly compared with that of Et treatment alone. However, Bb + Et treatment increased the relative abundance of plant beneficial bacteria significantly, for example, Burkholderia and Pseudomonas. Network analyses showed that the microbiome complexity increased after soil inoculation with B. bassiana. Taken together, these results revealed the potential mechanism by which entomopathogenic fungi exert biological control of maize leaf spot disease.

8.
J Mass Spectrom ; 56(11): e4787, 2021 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-34725896

RESUMO

American ginseng (AG), the underground part of Panax quinquefolium L., is composed of four morphological regions, including main root (MR), lateral root (LR), fibrous root (FR), and rhizome (RH). In the clinical, MR is the main medicinal region, other regions are rarely attention. Aiming at revealing the chemical composition of AG and making better use of AG, screening analysis and metabolomic analysis were both performed to profile MR, LR, FR, and RH. First, in the systematical screening analysis, a total of 134 compounds (including 122 shared components) with various structural patterns were identified and tentatively characterized. The results indicated that the phytochemicals with various structural types were rich in MR, LR, FR, and RH. Second, 6, 4, 8, and 11 chemical markers were identified from MR, LR, FR, and RH, respectively. Seven triterpene saponins (protopanaxatriol, quinquenoside R1 , ginsenoside Rc, Rk1 , Rg1 , Re, and vinaginsenoside R1 ) might be used for rapid differentiation of four morphological regions. This comprehensive profile study of metabolites illustrated the similarities and differences of phytochemicals in four morphological regions of AG. The results could be used for the quality control of AG and furnish a basis for the further development and utilization of AG sources.

9.
Front Pharmacol ; 12: 756975, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34776974

RESUMO

Liuweiwuling Tablet (LWWL) is a licensed Chinese patent medicine (approval number: Z20060238) included in the national health insurance for anti-inflammation of chronic HBV infection, whereas its anti-HBV effect remains clarification. The study aimed to clarify its antiviral effect and related mechanisms. HepG2.2.15 cells (wild-type HBV-replicating cells) and HepG2. A64 cells (entecavir-resistant HBV-replicating cells) were used for in vitro test. Hydrodynamic injection-mediated HBV-replicating mouse model was used for in vivo test. Active compounds and related mechanisms for antiviral effect of LWWL were analyzed using network pharmacology and transcriptomics. The inhibition rates of LWWL (0.8 mg/ml) on HBV DNA, HBsAg, and pgRNA were 57.06, 38.55, and 62.49% in HepG2.2.15 cells, and 51.57, 17.57, and 53.88% in HepG2. A64 cells, respectively. LWWL (2 g kg-1 d-1 for 4 weeks)-treated mice had 1.16 log10 IU/mL decrease of serum HBV DNA, and more than 50% decrease of serum HBsAg/HBeAg and hepatic HBsAg/HBcAg. Compared to tenofovir control, LWWL was less effective in suppressing HBV DNA but more effective in suppressing HBV antigens. Thirteen differentially-expressed genes were found in relation to HBV-host interaction and some of them were enriched in interferon (IFN)-ß pathway in LWWL-treated HepG2.2.15 cells. CD3+CD4+ T-cell frequency and serum IFN-γ were significantly increased in LWWL-treated mice compared to LWWL-untreated mice. Among 26 compounds with potential anti-HBV effects that were predicted by network pharmacology, four compounds (quercetin, luteolin, wogonin, and kaempferol) were experimentally confirmed to have antiviral potency. In conclusion, LWWL had potent inhibitory effect on both wild-type and entecavir-resistant HBV, which might be associated with increasing IFN-ß and IFN-γ production.

10.
Appl Opt ; 60(25): G217-G223, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34613212

RESUMO

Computer vision with a single-pixel camera is currently limited by a trade-off between reconstruction capability and image classification accuracy. If random projections are used to sample the scene, then reconstruction is possible but classification accuracy suffers, especially in cases with significant background signal. If data-driven projections are used, then classification accuracy improves and the effect of the background is diminished, but image recovery is not possible. Here, we employ a shallow neural network to nonlinearly convert from measurements acquired with random patterns to measurements acquired with data-driven patterns. The results demonstrate that this improves classification accuracy while still allowing for full reconstruction.

11.
Anal Chim Acta ; 1184: 338986, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34625249

RESUMO

Herein, a dual-signal amplification electrochemical sensing has been proposed for the ultrasensitive detection of uranyl ions (UO22+) by integration of gold nanoparticles (AuNPs) and hybridization chain reaction (HCR)-assisted synthesis of silver nanoclusters (AgNCs). In this sensing platform, AuNPs are used as an ideal signal amplification carrier, aiming at increasing the loads of UO22+-specific DNAzyme on the gold electrode. In the presence of UO22+, UO22+-specific DNAzyme can be activated, leading to the cleavage of substrate strands (S-DNA). Then, HCR is triggered to produce long dsDNA through hybridization the probe with the ssDNA on the electrode surface. As a result, an amplified electrochemical response can be detected by inserting a large amount of AgNCs generated in situ using dsDNA as template. Featured with amplification efficiency, good specificity and high sensitivity, the strategy could quantitatively detect UO22+ down to 6.2 pM with a linear calibration range from 20 pM to 5000 pM. The proposed sensing platform has been also successfully demonstrated the practical application of detecting UO22+, indicating that the developed method has the potential applications and can open up a new avenue for highly sensitive detection of UO22+ in environmental monitoring.


Assuntos
Ouro , Nanopartículas Metálicas , Técnicas Eletroquímicas , Íons , Prata
12.
World J Gastroenterol ; 27(36): 6128-6141, 2021 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-34629824

RESUMO

BACKGROUND: Multiple gastrointestinal stromal tumors (MGISTs) are specific and rare. Little is known about the impact of MGISTs on the survival of patients with gastrointestinal stromal tumors (GIST). The diagnosis, treatment and follow-up strategies of MGISTs is not specifically described in guidelines. AIM: To compare the clinicopathological characteristics and prognosis of MGISTs and solitary GISTs (SGISTs). METHODS: Patients diagnosed with primary GISTs from March 2010 to January 2020 were included. Due to the inhomogeneous distribution of several baseline characteristics and uneven MGIST and SGIST group sizes, propensity score matching was performed according to comorbidities, body mass index, tumor location, mitotic index, sex, age and American Society of Anesthesiologists score. Differences in clinicopathological characteristics and prognosis between patients with MGISTs and patients with SGISTs were compared. RESULTS: Among the entire cohort of 983 patients, the incidence of MGISTs was 4.17%. Before matching, patients with MGISTs and those with SGISTs had disparities in body mass index, surgical approach, tumor size and mitotic index. After 1:4 ratio matching, the clinical baseline data were comparable. The 5-year progression-free survival rate was 52.17% in the MGIST group and 75.00% in the SGIST group (P = 0.031). On multivariate analysis, tumor location, tumor size, mitotic index, imatinib treatment and MGISTs (hazard ratio = 2.431, 95% confidence interval = 1.097-5.386, P = 0.029) were identified as independent prognostic factors of progression-free survival. However, overall survival was similar between the SGIST and MGIST groups. CONCLUSION: Patients with MGISTs had poorer progression-free survival than patients with SGISTs. Risk criteria and diagnostic and treatment strategies should be developed to achieve personalized precision therapy and maximize the survival benefit.


Assuntos
Tumores do Estroma Gastrointestinal , Neoplasias Primárias Múltiplas , Tumores do Estroma Gastrointestinal/terapia , Humanos , Índice Mitótico , Prognóstico , Pontuação de Propensão
13.
Front Pharmacol ; 12: 740726, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34621172

RESUMO

Recombinant human keratinocyte growth factor-2 (rhKGF-2), an effective agent for the regeneration of epithelial tissue, was found to have great potential for use in treatments of corneal diseases that involve corneal epithelial defects. Furthermore, the safety of long-term and high-dose external use of KGF-2 eye drops in rabbits has been well established previously. The aim of this study is to determine the safe dose range and target organs for toxicity of rhKGF-2 eye drops in Macaca fascicularis (M. fascicularis). The M. fascicularis animals were administered with different doses of rhKGF-2 eye drops (125, 500, and 2000 µg/ml) for four consecutive weeks, followed by a 2 week recovery period. No significant differences in weight, electrocardiogram characteristics, blood and urine indexes, pathology, and bone marrow cells were detected among the animals in different groups. The corneas of some animals in the middle- and high-dose groups showed fluorescence when stained with sodium fluorescein, and then the staining disappeared on days 28 and 42. Anti-rhKGF-2 antibodies were detected in a small number of animals in the high-dose group, and their level decreased after rhKGF-2 withdrawal. No neutralizing antibodies were detected. The result demonstrated that there was no obvious adverse reaction when topical application of rhKGF-2 eye drops at the dosage of 125 or 500 µg/ml on the M. fascicularis. This study is of great significance for the future clinical transformation of rhKGF-2 eye drops.

14.
Shanghai Kou Qiang Yi Xue ; 30(4): 429-434, 2021 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-34693440

RESUMO

PURPOSE: To compare the efficacy of tongue appliance combined with chin-cup and facemask in the treatment of anterior crossbite, as well as the effects on the position of hyoid bone and airway, so as to provide reference for clinic. METHODS: Sixty cases with anterior crossbite were selected after treatment, using tongue appliance combined with chin-cup (n=30) and facemask (n=30). Cephalometric radiographs were taken before and after treatment, skeletal, dental, hyoid, and airway space measurements were analyzed with Winceph 9.0 and AutoCAD 2016. SPSS 21.0 software package was used for statistical analysis. RESULTS: Both appliances had a good effect on anterior crossbite. After treatment, SNA, ANS-PNS significantly increased(P<0.05), and SN-MP significantly increased(P<0.05). The upper anterior teeth showed a buccal inclination(P<0.01), the lower anterior teeth had a lingual inclination, and the overjet became normal(P<0.01). UL-E increased in both groups(P<0.05), PLA significantly increased in tongue appliance combined with chin-cup group(P<0.05). H-C3 decreased in both groups(P<0.05), while H-S, H-Ar increased(P<0.01), suggesting that the hyoid bone moved backward and downward. PNS-UPW increased in both groups(P<0.01), and U-MPW increased in facemask group(P<0.01). CONCLUSIONS: Facemask and tongue appliance combined with chin-cup can both promote the development of the maxilla, cause a clockwise rotation of the mandible, and effectively correct the anterior crossbite. Both methods can cause a backward and downward displacement of hyoid bone. Facemask can enlarge the width of nasopharynx and palatopharynx airway, while only the width of nasopharynx can be increased by tongue appliance combined with chin-cup.


Assuntos
Má Oclusão Classe III de Angle , Má Oclusão , Cefalometria , Queixo , Aparelhos de Tração Extrabucal , Humanos , Mandíbula , Máscaras , Maxila , Língua/diagnóstico por imagem
15.
Oxid Med Cell Longev ; 2021: 6256399, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34659637

RESUMO

The main objective of this study was to investigate the diurnal differences in Period 2 (PER2) expression in myocardial ischemia-reperfusion (I/R) injury. We investigated diurnal variations in oxidative stress and energy metabolism after myocardial I/R in vitro and in vivo. In addition, we also analyzed the effects of H2O2 treatment and serum shock in H9c2 cells transfected with silencing RNA against Per2 (siRNA-Per2) in vitro. We used C57BL/6 male mice to construct a model of I/R injury at zeitgeber time (ZT) 2 and ZT14 by synchronizing the circadian rhythms. Our in vivo analysis demonstrated that there were diurnal differences in the severity of injury caused by myocardial infarctions, with more injury occurring in the daytime. PER2 was significantly reduced in heart tissue in the daytime and was higher at night. Our results also showed that more severe injury of mitochondrial function in daytime produced more reactive oxygen species (ROS) and less ATP, which increased myocardial injury. In vitro, our findings presented a similar trend showing that apoptosis of H9c2 cells was increased when PER2 expression was lower. Meanwhile, downregulation of PER2 disrupted the oxidative balance by increasing ROS and mitochondrial injury. The result was a reduction in ATP and failure to provide sufficient energy protection for cardiomyocytes.

16.
Bipolar Disord ; 2021 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-34606159

RESUMO

BACKGROUND: Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. METHODS: In this study, we obtained resting-state functional magnetic resonance imaging (R-fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18-60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel-mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. RESULTS: As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q < .002, z =-7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age-related change in males instead of females. Besides, the reduction of MTG was found to be a male-special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First-episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. CONCLUSIONS: We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres.

17.
Nano Lett ; 21(19): 8236-8243, 2021 10 13.
Artigo em Inglês | MEDLINE | ID: mdl-34597051

RESUMO

Graphene oxide (GO) is receiving tremendous attention in membrane separation; however, its desalination performances remain suboptimal because of excessive swelling and tortuous transport pathways. Herein, we chemically joint GO nanosheets and phenolic nanomeshes together to form laminated membranes comprising through-plane nanopores and stabilized nanochannels. GO and phenolic/polyether nanosheets are mixed to form stacked structures and then treated in H2SO4 to remove polyether to produce nanomeshes and to chemically joint GO with phenolic nanomeshes. Thus-synthesized laminated membranes possess enhanced interlayer interactions and narrowed interlayer spacings down to 6.4 Å. They exhibit water permeance up to 165.6 L/(m2 h bar) and Na2SO4 rejection of 97%, outperforming most GO-based membranes reported so far. Moreover, the membranes are exceptionally stable in water because the chemically jointed laminates suppress the swelling of GO. This work reports hybrid laminated structures of GO and phenolic nanomeshes, which are highly desired in desalination and other applications.


Assuntos
Grafite , Nanoporos , Membranas Artificiais , Água
18.
Anal Chem ; 93(43): 14425-14431, 2021 11 02.
Artigo em Inglês | MEDLINE | ID: mdl-34672522

RESUMO

As the most important small molecules revealing the origins of life, amino acids (AAs) play essential roles in living organisms and their facile enantiodiscrimination has long been a great challenge for analytical chemists. Inspired by the specific stereomatching effect between biomolecules and AA enantiomers, herein, we first developed a bio-inspired highly sensitive platform based on an extended-gate metal-oxide-semiconductor field-effect-transistor (EG-MOSFET) for highly sensitive AA enantiodiscrimination. Bovine serum albumin (BSA) was self-assembled on deposited Au surfaces to afford the extended gate (EG) sensing unit, and its enantiorecognition ability was initially verified using common electrochemical techniques. The EG was thereafter installed to a MOSFET to build the desired BSA-EG-MOSFET highly sensitive chiral sensing platform, which realized the efficient enantiodiscrimination of essential AAs with high sensitivity, where effective chiral resolution was achieved at the femtomole level to phenylalanine (Phe). Combining molecular docking and circular dichroism spectroscopy, the weak intermolecular interactions between BSA and AAs enantiomers were investigated and the mechanism for signal amplification was proposed. Our results demonstrate that the as-fabricated biosensor has great potential in highly sensitive chiral sensing fields and can also afford a potential tool for biomolecular interaction investigations.


Assuntos
Aminoácidos , Técnicas Biossensoriais , Simulação de Acoplamento Molecular , Óxidos , Semicondutores
19.
Rev Sci Instrum ; 92(10): 105001, 2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34717407

RESUMO

In this work, indium tin oxide (ITO)/indium oxide (In2O3) thin film thermocouples (TFTCs) were prepared based on screen printing technology for high temperature measurement. With terpilenol as solvent, epoxy resin and polyether amine as binders and glass powders as additives, the ITO and In2O3 slurries were printed onto the Al2O3 substrate to form thermocouples. The effect on thermoelectric properties of the TFTCs with heat treatment and different contents of additives was investigated through microstructure observation and thermal cycle test. The static calibration experiment shows that the annealed TFTCs with 7.5 wt. % glass powders additives have the maximum Seebeck coefficient. The thermoelectric voltage output of the TFTCs can reach 126.5 mV at 1275 °C while the temperature difference is 1160 °C and the sensitivity of the TFTCs was 109.1 µV/°C. The drift rate of the TFTCs was 8.34 °C/h at a measuring time of 20 min at 1275 °C. The TFTCs prepared via screen printing technology with excellent thermoelectric properties and thermal stability are aimed to be a viable replacement for practical applications.

20.
Nucleic Acids Res ; 2021 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-34718726

RESUMO

Establishing an RNA-associated interaction repository facilitates the system-level understanding of RNA functions. However, as these interactions are distributed throughout various resources, an essential prerequisite for effectively applying these data requires that they are deposited together and annotated with confidence scores. Hence, we have updated the RNA-associated interaction database RNAInter (RNA Interactome Database) to version 4.0, which is freely accessible at http://www.rnainter.org or http://www.rna-society.org/rnainter/. Compared with previous versions, the current RNAInter not only contains an enlarged data set, but also an updated confidence scoring system. The merits of this 4.0 version can be summarized in the following points: (i) a redefined confidence scoring system as achieved by integrating the trust of experimental evidence, the trust of the scientific community and the types of tissues/cells, (ii) a redesigned fully functional database that enables for a more rapid retrieval and browsing of interactions via an upgraded user-friendly interface and (iii) an update of entries to >47 million by manually mining the literature and integrating six database resources with evidence from experimental and computational sources. Overall, RNAInter will provide a more comprehensive and readily accessible RNA interactome platform to investigate the regulatory landscape of cellular RNAs.

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