Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 611
Filtrar
1.
J Cell Physiol ; 235(2): 1405-1416, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31347176

RESUMO

Breast cancer patients with high expression of aldehyde dehydrogenases (ALDHs) cell population have higher tolerability to chemotherapy since the cells posses a characteristic of breast cancer stem cells (BCSCs) that are resistant to conventional chemotherapy. In this study, we found that the ALDH-positive cells were higher in CD44+ CD24- and CD44+ CD24- ESA+ BCSCs than that in both BT549 and MDA-MB-231 cell lines but microRNA-7 (miR-7) level was lower in CD44+ CD24- and CD44+ CD24- ESA+ BCSCs than that in MDA-MB-231 cells. Moreover, miR-7 overexpression in MDA-MB-231 cells decreased ALDH1A3 activity by miR-7 directly binding to the 3'-untranslated region of ALDH1A3; while the ALDH1A3 expression was downregulated in MDA-MB-231 cells, the expressions of CD44 and Epithelium Specific Antigen (ESA) were reduced along with decreasing the BCSC subpopulation. Significantly, enforced expression of miR-7 in CD44+ CD24- ESA+ BCSC markedly inhibited the BCSC-driven xenograft growth in mice by decreasing an expression of ALDH1A3. Collectively, the findings demonstrate the miR-7 inhibits breast cancer growth via suppressing ALDH1A3 activity concomitant with decreasing BCSC subpopulation. This approach may be considered for an investigation on clinical treatment of breast cancers.

2.
Chemosphere ; 240: 124884, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31542586

RESUMO

Antibiotics and heavy metals are frequently detected simultaneously in water environment. In this study, the competitive adsorption behavior of tylosin (TYL) and sulfamethoxazole (SMX) on nano-hydroxyapatite modified biochar (nHAP@biochar) in accordance with Cu(II) in single, binary and ternary systems was investigated. The specific surface area of nHAP@biochar was 566.056 m2/g. The adsorption of TYL on nHAP@biochar reduced by 13.36%-41.04% or 9.92%-38.69% with Cu(II) and SMX in the solution, respectively. The suppression of SMX was stronger than Cu(II) on the adsorption of TYL when the SMX or Cu(II) was constant. The adsorption of SMX increased by 2.01-3.56 times in the present of Cu(II), while suppressed by TYL up to 42.30%. Due to the bridging of TYL or SMX between the nHAP@biochar and Cu(II) and destroying of bound water surrounded, the adsorption of Cu(II) increased to a greater extent. Electrostatic interaction and H-bond were the two main interactions between TYL, SMX and Cu(II) and nHAP@biochar. π-π interactions was also interaction between the SMX and nHAP@biochar.

3.
Chemosphere ; 240: 124896, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31563716

RESUMO

Groundwater contaminated by hexavalent chromium (Cr(VI)) has posed severe threat to the environment and public health. Although heterotrophic bioremediation has been known as an efficient approach, little is explored on mineral nutrient source addition such as phosphorus minerals. In this study, the stabilization and sustainability of phosphorus minerals for providing phosphorus has been investigated, and the enhancement of Cr(VI) removal by mixed bacterial consortium coupled with phosphorus minerals was also observed and further verified, with 1.4-3.9 times K values (first-order) increase under different conditions. We demonstrated that the applied of phosphorus minerals facilitated the reduction of Cr(VI) and the removal of Cr(III), promoted the resistance of Cr(VI) and the generation of antioxidase, and engendered the evolution of microbial community structures and functional genes. These findings provide a new insight for enhancement of Cr(VI)-contaminated groundwater in-situ remediation.

4.
Immunol Lett ; 2019 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-31669546

RESUMO

Mucosal immunization has potential benefits over conventional parenteral immunization, eliciting immune defense in both mucosal and systemic tissue for protecting from pathogen invasion at mucosal surfaces. To provide a first line of protection at these entry ports, mucosal vaccines have been developed and hold a significant promise for reducing the burden of infectious diseases. However, until very recently, only limited mucosal vaccines are available. This review summarizes recent advances in selected aspects regarding mucosal vaccination, including appropriate administration routes, reasonable formulations, antigen-sampling and immune responses of mucosal immunity, and the strategies used to improve mucosal vaccine efficacy. Finally, the challenges of developing successful mucosal vaccines and the potential solutions are discussed.

5.
Pharmazie ; 74(11): 671-674, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31739835

RESUMO

Gamma-Glutamyl hydrolase (GGH) plays an important role in the disposition of anti-folate analogs. Several studies noted the pharmacological relevance of rs3758149 C/T polymorphism located in the human GGH promoter. The present study aimed to investigate the role of rs3758149 C/T polymorphism and transcription factors in the regulation of GGH expression in human acute lymphoblastic leukemia (ALL) CEM/C1 cells. Compared with the rs3758149 T allele, the C allele showed significantly higher transcriptional activity in luciferase reporter assays, as well as a stronger binding affinity for the nuclear protein extracts in an electrophoretic mobility shift assay. Sp1 was identified as the target transcription factor that exhibited allele-specific binding to the location of rs3758149 C/T polymorphism in the chromatin immunoprecipitation assay. Overexpression of Sp1 led to enhanced GGH promoter activity and GGH mRNA expression in allele-specific manners. These findings suggested that Sp1 acted as a positive regulator of human GGH transcription through the rs3758149 polymorphism in CEM/C1 cells. This study contributed to the present understanding of the mechanisms underlying variable responses of ALL to anti-folates.

6.
Artigo em Inglês | MEDLINE | ID: mdl-31697229

RESUMO

A Gram-stain-negative, yellow-green bacterium, designated 1.1416T, was isolated from wormcast of Eisenia foetida. The strain was non-motile, rod-shaped, and grew optimally on NA medium at 30 °C, pH 7.0 and with 0 % (w/v) NaCl. On the basis of the 16S rRNA gene sequence and phylogenetic analysis, 1.1416T showed the highest degree of 16S rRNA gene sequence similarity to Luteimonas arsenica 26-35T (96.2 %), followed by Luteimonas lutimaris G3T (96.1 %). The respiratory quinone of 1.1416T was ubiquinone-8 (Q-8), and its major cellular fatty acids were iso-C15 : 0 (39.8 %), summed feature 9 (iso-C17 : 1 ω9c or C16 : 0 10-methyl) (18.6 %). The major polar lipids of 1.1416T were phosphatidylglycerol, diphosphatidylglycerol, phosphatidylethanolamine and six unidentified phospholipids. The genomic DNA G+C content of 1.1416T was 71.0 mol%. According to the results of the phenotypic and chemotaxonomic phylogenetic analyses, strain 1.1416T represents a novel species of the genus Luteimonas, for which the name Luteimonas lumbrici sp. nov. is proposed, with strain 1.1416T (=KCTC 62979T=CCTCC AB 2018348T) as the type strain.

7.
Am J Emerg Med ; 2019 Oct 24.
Artigo em Inglês | MEDLINE | ID: mdl-31704061

RESUMO

BACKGROUND: The purpose of this study was to evaluate the clinical symptoms, surgical management, and outcomes of pregnant women with adnexal torsion due to assisted reproductive technology. METHODS: It was a retrospective study that include 17 pregnant women with adnexal torsion, in which the maternal age, type of fertilization, gestational age, clinical symptoms, ultrasonic findings, side affected by the disease, surgical method, and pregnancy outcomes were evaluated. RESULTS: A total of 17 patients with adnexal torsion were included in this study, of which 8 patients conceived by in vitro fertilization-embryo transfer (IVF-ET), 1 by artificial insemination (AIH), and the other 8 conceived naturally after ovulation induction. About 14 were reported to have occurred in the first trimester of pregnancy, 1 case in the second trimester, and the other 2 in the third trimester. Clinical symptoms were abdominal pain with or without nausea and vomiting. 14 cases occurred in the right adnexa and the other 3 in the left. 5 of the patients underwent laparoscopy, and the other 12 underwent laparotomy. 8 cases were of full- term delivery, 6 twins gave birth prematurely, and 3 patients had inevitable abortion. CONCLUSIONS: Adnexal torsion is an acute onset of lower abdominal pain in women, which seldom occurs during pregnancy. However, because of the wide application of assisted reproductive technology (ART), its incidence has increased. Early diagnosis and treatment can lead to better results.

8.
Artigo em Inglês | MEDLINE | ID: mdl-31730927

RESUMO

With the development of aquaculture industry, high-carbohydrate diet is used to stimulate protein-sparing effect and reduce feed cost. However, fish utilize carbohydrates poorly in general, and instead, high level of carbohydrates in the diet influence the growth condition of fish. How to alleviate the side effects of high carbohydrate diet on fish health has attracted more and more attentions. In the present study, Nile tilapia (Oreochromis niloticus) were fed with 25% and 45% of carbohydrate diet for eight weeks. Higher body weight but lower resistance to pathogen was found in 45% carbohydrate diet group. Higher expression level of inflammation cytokines, increased expression of total NF-κB protein and phosphorylated NF-κB protein (p-NF-κB) were detected in higher carbohydrate group. Concentration of short-chain fatty acids (SCFAs) was measured and the results indicated that high-carbohydrate diet decreased acetate content in the intestine. In order to detect the relationship between the decreased concentration of acetate and lower resistance to pathogen in high-carbohydrate group, 45% of carbohydrate diets (HC) supplemented with different concentrations of sodium acetate (HC + LA, 100 mmol/L; HC + MA, 200 mmol/L; HC + HA, 400 mmol/L) were used to raise Nile Tilapia for eight weeks. The results indicated that addition of 200 mmol/L sodium acetate (HC + MA) reduced the mortality when fish were challenged with Aeromonas hydrophila. Furthermore, we also found that addition of 200 mmol/L sodium acetate mainly inhibited p38 mitogen-activated protein kinase (p38MAPK) and NF-κB phosphorylation to decrease the expression level of inflammation cytokines (IL-8, IL-12, TNF-α and IL-1ß) in the intestine. The present study indicated that certain concentration of sodium acetate could alleviate high-carbohydrate induced intestinal inflammation mainly by suppressing MAPK activation and NF-κB phosphorylation.

11.
Opt Express ; 27(21): 30909-30918, 2019 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-31684332

RESUMO

Aluminum (Al) plasmonic nanostructures have recently demonstrated remarkable optical nonlinear phenomena, such as enhanced second harmonic (SH) generation. However, the relatively weak field enhancement resulted from large optical losses associated with aluminum nanostructures in combination with the difficulties in controlling the emission polarization pose as a challenge for SH enhancement and tuning. In this paper, we show that the SH emission of aluminum nanostructures can be efficiently enhanced with the polarization properties simultaneously tunable by using metal-insulator-metal (MIM) nanostructures, constituting of Al cross nanoantenna arrays on top of Al mirrors with a SiO2 spacing layer. Specifically, femtosecond laser beam with a linear polarization parallel to one arm illuminates on the structure while the orthogonal arms were physically modified by the laser-induced photothermal reshaping technique to control the SH radiation by the plasmonic resonances. Under the resonance at the SH wavelength, we observed one order of magnitude larger emission enhancement compared to that at the off-resonant condition. Interestingly, the polarization states can be well manipulated simultaneously by controlling the resonances of the orthogonal arms. The enhanced SH conversion and tunable polarization states pave the way for the development of nonlinear optical sources and advanced functional metasurfaces.

12.
Life Sci ; 239: 116946, 2019 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-31610202

RESUMO

AIMS: Infantile hemangioma (IH) is the most common vascular neoplasm in infant and young children. Long non-coding RNAs (lncRNAs) are known to be associated with IH. This study aims to investigate the role and underlying mechanism of lncRNA-MALAT1 in IH. MAIN METHODS: qRT-PCR was used to quantify the expressions of MALAT1, miR-424, and MEKK3 in IH tissues. The cell proliferation, apoptosis, migration, invasion, and tube formation ability were assessed by MTT assay, colony formation assay, flow cytometric analysis, transwell assay and tube formation assay, respectively. The interaction among MALAT1, miR-424 and MEKK3 was evaluated by luciferase reporter assay. Immunohistochemistry (IHC) and Western blotting were utilized to evaluate the expression levels of MEKK3, Ki-67 and NF-κB pathway-related proteins both in vitro and in vivo. KEY FINDINGS: In IH tissues, MALAT1 and MEKK3 were overexpressed while miR-424 was down-regulated. Silencing MALAT1 or overexpression of miR-424 significantly inhibited the IH cell proliferation, migration and tube formation, but promoted the cell apoptosis. Knockdown of MALAT1 suppressed the expression of MEKK3 and inactivated the IKK/NF-κB pathway by sponging miR-424. Overexpression of MEKK3 in HemEcs reversed the impact of knockdown of MALAT1 and overexpression of miR-424 on the cell proliferation, apoptosis, migration, invasion and tube formation rate. The tumor xenografts experiments demonstrated that silencing MALAT1 significantly inhibited the tumor growth in vivo and Ki-67 in the tumor tissues was also significantly suppressed. SIGNIFICANCE: MALAT1 promoted the IH progression through inhibiting miR-424 to activate MEKK3-mediated IKK/NF-κB pathway, suggesting that MALAT1, miR-424 and MEKK3 could be used as potential targets to improve IH treatment efficiency.

13.
Medicine (Baltimore) ; 98(41): e17521, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31593123

RESUMO

BACKGROUND: Previous studies have neglected to report the specific action of different probiotic genera in preterm infants. To evaluate the efficacy and safety of specific probiotic genera, we performed a network meta-analysis (NMA) to identify the best prevention strategy for necrotizing enterocolitis in preterm infants. METHODS: MEDLINE, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials had been searched for randomized control trials reporting the probiotics strategy for premature infants. RESULTS: We identified 34 eligible studies of 9161 participants. The intervention in the observation group was to add probiotics for feeding: Lactobacilli in 6 studies; Bifidobacterium in 8 studies; Bacillus in 1 study; Saccharomyces in 4 studies and probiotic mixture in 15 studies. This NMA showed a significant advantage of probiotic mixture and Bifidobacterium to prevent the incidence of necrotizing enterocolitis in preterm infants. A probiotic mixture showed effectiveness in reducing mortality in preterm infants. CONCLUSION: The recent literature has reported a total of 5 probiotic strategies, including Bacillus, Bifidobacterium, Lactobacillus, Saccharomyces, and probiotic mixture. Our thorough review and NMA provided a piece of available evidence to choose optimal probiotics prophylactic strategy for premature infants. The results indicated that probiotic mixture and Bifidobacterium showed a stronger advantage to use in preterm infants; the other probiotic genera failed to show an obvious effect to reduce the incidence of NEC, sepsis and all-cause death. More trials need to be performed to determine the optimal probiotic treatment strategy to prevent preterm related complications.


Assuntos
Enterocolite Necrosante/tratamento farmacológico , Enterocolite Necrosante/prevenção & controle , Doenças do Recém-Nascido/prevenção & controle , Probióticos/uso terapêutico , Bifidobacterium/fisiologia , Enterocolite Necrosante/epidemiologia , Humanos , Incidência , Lactente , Recém-Nascido , Doenças do Recém-Nascido/epidemiologia , Recém-Nascido Prematuro , Lactobacillus/fisiologia , Placebos/administração & dosagem , Cuidado Pré-Natal/métodos , Probióticos/administração & dosagem , Ensaios Clínicos Controlados Aleatórios como Assunto , Sepse/epidemiologia , Sepse/mortalidade , Resultado do Tratamento
14.
Anal Chem ; 91(21): 13501-13507, 2019 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-31571476

RESUMO

The Wnt pathway is dysregulated and activated in many human malignancies. More than 90% of colon cancers have variations in the Wnt pathway. Sulindac, a drug that targets protein Dvl of the Wnt/Dvl/ß-catenin pathway, which regulates cancer gene expression, has been reported to significantly reduce the incidence and the risk of death from colorectal cancer and other types of cancer. Herein, a dual functional compound (SLN) containing Sulindac and a linked fluorophore is first reported, combining the functions of lighting up colon cancer cells as a flare and inhibiting colon tumors as a drug. SLN can not only mark the Dvl protein in the Wnt pathway to recognize tumors layer by layer but also achieve effective inhibition of colon cancer, providing a promising reagent for chemotherapy and a fluorescent indicator for surgery during the removal the colon tumors in situ.

15.
ACS Nano ; 13(10): 10860-10868, 2019 Oct 22.
Artigo em Inglês | MEDLINE | ID: mdl-31589406

RESUMO

The spatial organization of molecules in cell membranes and their dynamic interactions play a central role in regulating cell functions. Single-particle tracking (SPT), a technique in which single molecules are imaged and tracked in real time, has led to breakthrough discoveries regarding these spatiotemporal complexities of cell membranes. There are, however, emerging concerns about factors that might produce misleading interpretations of SPT results. Here, we briefly review the application of SPT to understanding the nanoscale heterogeneities of plasma membranes, with a focus on the unique challenges, pitfalls, and limitations that confront the use of nanoparticles as imaging probes for tracking the dynamics of single molecules in cell membranes.

16.
Bioresour Technol ; 294: 122213, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31605915

RESUMO

Chromium(VI) contaminated groundwater has become an increasingly prominent problem due to its extensive application in industry. Based on the easy-loss defect of microbial in practical application and previous research on the coupling enhancement of Cr(VI) bioreduction by phosphorus minerals, Microbial-Phosphorus minerals-Alginate (MPA) immobilized particles were proposed and investigated in this study. The feasibility of MPA immobilized particles were proved, with the higher reduction efficiency, lower phosphorus surplus, significant 94% of total Cr reduction and 85% of intragranular fixation. These superiorities were also obtained at different pH and initial Cr(VI) concentration conditions. Furthermore, the mechanisms of the enhancement of MPA were investigated from microbial level (microbial biomass, antioxidase, gene expression and microbial community analysis) and physics level (adsorption kinetic and isotherm), where the speculation that the reduction mainly took place outside the particles was proposed. This research provides a new approach for the practical application of Cr(VI)-contaminated groundwater in-situ bioremediation.


Assuntos
Fósforo , Poluentes Químicos da Água , Adsorção , Alginatos , Cromo , Estudos de Viabilidade , Minerais
17.
Zhongguo Dang Dai Er Ke Za Zhi ; 21(10): 972-976, 2019 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-31642429

RESUMO

OBJECTIVE: To study the types and characteristics of TUBB1 mutation in children with congenital hypothyroidism (CH) and thyroid dysgenesis (TD) in Shandong, China. METHODS: Mutations of the whole coding region of the TUBB1 gene were analyzed for 289 children with CH and TD in Shandong. Whole-genome DNA was extracted from peripheral blood leukocytes. PCR multiplication was performed for the whole coding region of the TUBB1 gene. Sanger sequencing was performed for the PCR products, and a biological information analysis was performed. RESULTS: Among the 289 children with CH and TD, 4 (1.4%) were found to have a c.952C>T(p.R318W) heterozygous mutation in the TUBB1 gene, resulting in the change of tryptophan into arginine at codon 318 of TUBB1 protein. This mutation was evaluated as "potentially pathogenic" based on the classification criteria and guidelines for genetic variation by American College of Medical Genetics and Genomics. CONCLUSIONS: A novel mutation is detected in the exon of the TUBB1 gene in children with CH and TD in Shandong, suggesting that the TUBB1 gene may be a candidate pathogenic gene for CH children with TD.


Assuntos
Hipotireoidismo Congênito , Disgenesia da Tireoide , Tubulina (Proteína)/genética , Criança , China , Hipotireoidismo Congênito/genética , Análise Mutacional de DNA , Humanos , Mutação , Disgenesia da Tireoide/genética
18.
World J Gastroenterol ; 25(38): 5850-5861, 2019 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-31636477

RESUMO

BACKGROUND: Thiopurine-induced leukopenia (TIL) is a life-threatening toxicity and occurs with a high frequency in the Asian population. Although nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) variants significantly improve the predictive sensitivity of TIL, more than 50% of cases of this toxicity cannot be predicted by this mutation. The potential use of the 6-thioguanine nucleotide (6TGN) level to predict TIL has been explored, but no decisive conclusion has been reached. Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 R139C genotypes? AIM: To determine the 6TGN cut-off levels after dividing patients into subgroups according to their NUDT15 R139C genotypes. METHODS: Patients' clinical and epidemiological characteristics were collected from medical records from July 2014 to February 2017. NUDT15 R139C, thiopurine S-methyltransferase, and 6TGN concentrations were measured. RESULTS: A total of 411 Crohn's disease patients were included. TIL was observed in 72 individuals with a median 6TGN level of 323.4 pmol/8 × 108 red blood cells (RBC), which was not different from that of patients without TIL (P = 0.071). Then, we compared the 6TGN levels based on NUDT15 R139C. For CC (n = 342) and CT (n = 65) genotypes, the median 6TGN level in patients with TIL was significantly higher than that in patients without (474.8 vs 306.0 pmol/8 × 108 RBC, P = 9.4 × 10-5; 291.7 vs 217.6 pmol/8 × 108 RBC, P = 0.039, respectively). The four TT carriers developed TIL, with a median 6TGN concentration of 135.8 pmol/8 × 108 RBC. The 6TGN cut-off levels were 411.5 and 319.2 pmol/8 × 108 RBC for the CC and CT groups, respectively. CONCLUSION: The predictive sensitivity of TIL based on 6TGN is dramatically increased after subgrouping according to NUDT15 R139C genotypes. Applying 6TGN cut-off levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.

19.
Biomater Sci ; 2019 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-31664285

RESUMO

Fe3O4 magnetic nanoparticles (MNPs), as one of the most intensively researched NPs, have a range of applications in cancer treatments. In current research, we have focused on the influences of MNPs on cancer cells. We chose polyethyleneimine (PEI) coated MNPs (PEI-MNPs) as a model and they are colloidally stable in biological media. It can be proved that PEI-MNPs result in autophagy induction via mTOR-Akt-p70S6 K and ATG7 signaling pathways. For the first time, we have reported that PEI-MNPs activate both NF-κB and TGF-ß signaling, two key pro-inflammatory pathways, in cancer cells. More significantly, we have found that autophagy induction and NF-κB and TGF-ß activation can be efficiently suppressed through the inhibition of PEI-MNP dependent reactive oxygen species (ROS) over-production. ROS are deemed as a 'double edge sword' for cancer cells, owing to the cancer-suppressing and cancer-promoting actions. Our findings would be useful for designing MNPs induced ROS anti-cancer strategies or diminishing long-term toxic effects.

20.
ACS Appl Mater Interfaces ; 11(37): 33859-33867, 2019 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-31487151

RESUMO

Magnetic ferroferric oxide-supported bimetallic Pd-In cluster sub-nanoparticles were used for the first time for the catalytic reduction of nitrates. Due to the unique properties of the FeOx support, the PdIn active centers could be highly dispersed in both nano- and sub-nanoscales. A variety of characterizations and the charge density difference model confirm that a strong metal-support interaction exists between the active sites and the support. The PdIn nanoparticles on FeOx show high selectivity toward nitrogen and excellent cyclic activity due to ferromagnetism, which broaden its prospect in practical water treatment. Moreover, the active centers in the sub-nanoscale are used in the nitrate reduction process for the first time and they show a distinct higher activity in denitration. The rate constant for nitrate conversion on PdIn sub-nanoparticles is larger than that for its nanometer counterpart based on the Langmuir-Hinshelwood model. High turnover frequency value and ammonia selectivity are achieved for the small-sized sub-nanocatalyst. The FeOx-supported PdIn nanoparticles and sub-nanoparticles have two application areas in water purification and ammonia recovery, respectively. Density functional theory calculations on the adsorption energies of elemental reactions are also performed, which shed some light on the catalysis mechanism and catalyst design.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA