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1.
Int J Biol Macromol ; 154: 732-738, 2020 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-32194111

RESUMO

This paper reported a facile strategy to fabricate ionically crosslinked supramolecular film, in which an in situ formed chitosan ionic film was produced by post-crosslinking the chitosan chains using negatively charged anion polyoxometalate. The incorporation of polyoxometalate into the chitosan ionic system accelerated the crosslinked degree, as evidenced by an increase in surface wrinkle via scanning electron microscopy. Interestingly, the resultant supramolecular film realized the combination of prominent antimicrobial effect and excellent biocompatibility, which was considered to have enormous application potential range from biomedical to environmental science.

2.
Bioorg Chem ; 97: 103714, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32146181

RESUMO

Six new triterpenoids (1-6) and 22 known analogues (7-28), were separated from the aerial parts of Anchusa italica Retz., a traditional Uygur medicine for treating cardiovascular and cerebrovascular diseases in the Xinjiang region, China. The possible effects of compounds 1-28 on hypoxia/reoxygenation (H/R) induced cardiomyocytes injury were assayed, and compounds 4, 6-17, 21-22 and 26-28 showed significant protective effects. Further, the representative new compound 6 significantly suppressed the levels of H/R-induced apoptosis and autophagy in neonatal rat cardiomyocytes, with the reversing of the downregulated expression of Bcl-2 and upregulated expression of Bax and Beclin-1 by compound 6 treatment in neonatal rat cardiomyocytes following H/R injury. In addition, compound 6 protected cardiomyocyte from H/R injury, and pretreatment with 6 could decrease CK and LDH levels. Compound 6 also alleviated H/R-induced phosphorylation of p38 MAPK in neonatal rat cardiomyocytes. Therefore, tripterpenoid 6 and its analogues may be the pharmacodyamic material of A. italica, and offer a promising therapeutic approach for treating cardiomyocyte injury induced by H/R.

3.
Bioorg Chem ; 96: 103609, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32007722

RESUMO

Hexokinase 2 (HK2) is over-expressed in most of human cancers and has been proved to be a promising target for cancer therapy. In this study, based on the structure of HK2, we screened over 6 millions of compounds to obtain the lead. A total of 26 (E)-N'-(2,3,4-trihydroxybenzylidene) arylhydrazide derivatives were then designed, synthesized, and evaluated for their HK2 enzyme activity and IC50 values against two cancer cell lines. Most of the 26 target compounds showed excellently in vitro activity. Among them, compound 3j showed the strongest inhibitory effects on HK2 enzyme activity with an IC50 of 0.53 ± 0.13 µM and exhibited the most potent growth inhibition against SW480 cells with an IC50 of 7.13 ± 1.12 µM, which deserves further studies.

4.
Phys Chem Chem Phys ; 22(2): 430-436, 2020 Jan 02.
Artigo em Inglês | MEDLINE | ID: mdl-31675033

RESUMO

Hydrogen energy is a high-efficiency and clean energy, but the problem of storage still prevents its extensive use. Large-surface-area, two-dimensional (2D) layered materials have an advantage in hydrogen storage applications. Monolayer MoS2 is a typical 2D material that has been widely studied recently. And the 1T' phase of MoS2 is a focus especially for studies concerning hydrogen. Here, first-principles calculations are carried out to investigate the adsorption behaviors of hydrogen molecules on 1T' MoS2. Comparing with other MoS2-based materials, such as doped or decorated 2H-MoS2, 1T' MoS2 has even better performance in hydrogen adsorption, and its preparation is easier. In multiple hydrogen molecule adsorption, the material shows good stability and appropriate adsorption energy while adsorbing hydrogen molecules. With the researches in this paper, the connection between the adsorption energy and hydrogen mass fraction was set up. This can provide a reference for further studies on hydrogen storage applications.

5.
Anal Bioanal Chem ; 412(2): 473-480, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31792597

RESUMO

A phenyl-based polymer monolithic column was prepared via free radical polymerization in a stainless steel column with the size of 4.6 mm i.d. × 50 mm, using ethylene glycol phenyl ether acrylate as the monomer. The resulting monolithic column shows high porosity of 73.42% and relative uniform pore structure, as characterized by mercury porosimetry and scanning electron microscopy, respectively. The optimized polymer monolith column was used for on-line solid-phase extraction prior to the reversed phase mode HPLC-UV analysis for the determination of dioscin in human plasma, using a COSMOSIL C18 column (4.6 mm × 150 mm, 4.5 µm). Water was used to wash non-retained components from the SPE sorbent, and methanol water (80:20, V/V) was used as the mobile phase for isocratic elution of dioscin. The maximum adsorbed quantity of dioscin to the SPE column is 6.79 mg/g, which is high enough for the quantitative analysis of dioscin in plasma, due to the low content of dioscin in plasma. The method was validated by assessing the linearity, lower limit of quantification, intra- and inter-day precision, accuracy, and repeatability. The developed method was applied for the analysis of dioscin in plasma from a volunteer who had orally administered an aqueous extract of dioscorea nipponica rhizome, showing the method capable of detecting dioscin in the plasma. These results show that the developed method is a rapid method for on-line solid-phase extraction and determination of dioscin from plasma, exhibiting good selectivity with hydrogen bond interaction and hydrophobic interaction, good clean-up ability, cost-saving, and time-saving. Graphical abstract.


Assuntos
Cromatografia Líquida de Alta Pressão/métodos , Diosgenina/análogos & derivados , Extração em Fase Sólida/métodos , Diosgenina/sangue , Diosgenina/normas , Humanos , Limite de Detecção , Padrões de Referência , Reprodutibilidade dos Testes , Extração em Fase Sólida/instrumentação
6.
Pharmacol Res ; 151: 104547, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31734345

RESUMO

B-cell lymphoma-extra large (Bcl-XL) is one of the anti-apoptotic proteins of the Bcl-2 family that is localized in the mitochondria. Bcl-XL is one of the key regulators of apoptosis that can also regulate other important cellular functions. Bcl-XL is overexpressed in many cancers, and its inhibitors have shown good therapeutic effects. Bcl-XL interacts with Beclin 1, a key factor regulating autophagy. Bcl-XL is essential for the survival of neurons and plays protective roles in neuronal injuries. It can promote the growth of neurons and the correct formation of neural networks, enhance synaptic plasticity, and control neurotoxicity. Bcl-XL can also promote the transport of Ca2+ to mitochondria, increase the production of ATP, and improve metabolic efficiency. In addition, targeting Bcl-XL has shown potential value in autoimmune diseases and aging. In this review, we summarize the functions of Bcl-XL in cancer, autophagy, Ca2+ signaling, neuroprotection, neuronal growth and synaptic plasticity, energy metabolism, immunity, and senescence as revealed by investigations conducted in the past 10 years. Moreover, we list some inhibitors that have been developed based on the functions of Bcl-XL.

7.
Bioorg Med Chem Lett ; 30(1): 126781, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31706669

RESUMO

In this article, a new compound H2[{Cu(HL)(H2O)}2(P2Mo5O23)]·5H2O (1) (HL = 2-acetylpyrazine thiosemicarbazone) has been synthesized and structurally characterized by single-crystal X-ray diffraction of and other detection techniques. Interestingly, the structure of 1 is different from many reported copper-based complexes, in which the [P2Mo5O23]6-, two Cu2+ ions and two HL were directly connected by covalent bands. Biological studies demonstrated that 1 indicated moderate antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), and a better cytotoxicity against human hepatic cancer line (SMMC-7721) than Mitoxantrone (Mito), the current clinical anticancer drug. Besides, the antibacterial mechanisms of 1 have been studied by the membrane integrity disruption, the destructive reactive oxygen species generation (ROS), the glutathione (GSH) depletion and the depressed enzymatic activity of respiratory chain dehydrogenases (RCD). These results revealed that the combination of HL, Cu2+, [P2Mo5O23]6- shows a higher antibacterial and cytotoxic activity.

8.
ACS Appl Mater Interfaces ; 12(2): 2199-2206, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31859478

RESUMO

Consecutive photoinduced electron transfer (ConPET) has advantages on overcoming the current energetic limitation of visible-light photoredox catalysis for utilizing the energies of two photons in one catalytic cycle. A heterogeneous approach for radical chain reduction of various aryl bromides and chlorides without adding any cocatalyst is introduced by incorporating polyoxometalates (POMs) and amine catalysts into a naphthalenediimide (NDI)-based polymer. CoW-DPNDI-PYI exhibits high activity in the photocatalytic reduction of aryl halides by the synergistic effects of ConPET and hydrogen-atom-transfer (HAT) processes and an enzyme-mimicking CO2 cycloaddition reaction. The ConPET process with N,N'-bis(4-pyridylmethyl)naphthalenediimide (DPNDI) facilitates effective solar energy conversion. POMs and amine catalysts, as efficient HAT catalysts and electron donors, improve the generation of the ConPET process. The success of this work demonstrates the great application of the synergistic effects of ConPET and HAT processes in heterogeneous photocatalysis C-H arylation.

9.
Artigo em Inglês | MEDLINE | ID: mdl-31518898

RESUMO

A polymer-based chromatographic monolithic column was prepared via in-situ radical polymerization using tetrahydrofurfuryl methacrylate as the monomer. The homemade column was used for the separation and quantitative analysis of alkaloids, including piperine from Piper longum (fruit of Piper longum Linn.) and pepper (fruit of Piper nigrum L.), hydroxy-α-sanshool, and hydroxy-γ-sanshool from zanthoxylum (fruit of Zanthoxylum bungeanum Maxim), as well as caffeine from Wuyi rock tea. The chromatographic fractions were identified by mass spectrometry. Single factor test and orthogonal test were both carried out to optimize the extraction conditions. The method validation indicated that the accuracy represented by spiked recovery ranged in 98.89%-102.06%, the correlation coefficients in 0.99986-0.99999. These results show that the prepared monolithic column can be successfully used to quantitatively analyse alkaloids from the real medicinal and edible plant foods with reversed-phase mechanism, which can avoid the long analytical time using traditional packed C18 column. The present method is a simple, and inexpensive method for quantitatively analysing alkaloids from medicinal and edible plant foods, exhibiting good specificity and durability.


Assuntos
Alcaloides/análise , Cromatografia Líquida/métodos , Plantas Comestíveis/química , Plantas Medicinais/química , Limite de Detecção , Modelos Lineares , Metacrilatos , Extratos Vegetais/química , Reprodutibilidade dos Testes
10.
Inorg Chem ; 58(19): 12529-12533, 2019 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-31512474

RESUMO

Developing efficient photocatalysts for direct oxidative coupling of alkenes and amines with O2 under mild conditions is very significant. Herein, ZnW-PYI is well-designed by assembling a [PZnW11O39(H2O)]5- photooxidation catalyst and chiral aminocatalyst pyrrolidine-2-ylimidazole (PYI) via a coordination model. ZnW-PYI efficiently catalyzed the synthesis of imines from alkenes and amines using O2 as the oxidant through nucleophilic catalysis by employing pyrrolidine as an organocatalyst. Combining a polyoxometalate and PYI within one single framework is an effective approach not only for stabilization and heterogenization of the redox-active catalyst and aminocatalyst but also for realization of compatibility between the reaction intermediates and synergy of multiple catalytic cycles.

11.
Nanomaterials (Basel) ; 9(9)2019 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-31487818

RESUMO

The ternary nanocomposites Fe3O4/Ag/polyoxometalates (Fe3O4/Ag/POMs) with core-shell-core nanostructure were synthesized by coating [Cu(C6H6N2O)2(H2O)]H2[Cu(C6H6N2O)2(P2Mo5O23)]·4H2O polyoxometalates on the surface of Fe3O4/Ag (core-shell) nanoparticles. The transmission electron microscopy/high resolution transmission electron microscopy (HR-TEM) and X-ray powder diffraction (XRD) analyses show that the Fe3O4/Ag/POMs ternary nanocomposites reveal a core-shell-core nanostructure, good dispersibility, and high crystallinity. The vibrating sample magnetometer (VSM) and physical property measurement system (PPMS) demonstrated the good magnetic properties and superparamagnetic behavior of the nanocomposites at 300 K. The UV-vis spectroscopy displayed the broadband absorption of the Fe3O4/Ag/POMs with the maximum surface plasmon resonance of Ag nanostructure around 420 nm. The dye removal capacity of Fe3O4/Ag/POMs was investigated using methylene blue (MB) as a probe. Through adsorption and photocatalysis, the nanocomposites could quickly remove MB with a removal efficiency of 98.7% under the irradiation of visible light at room temperature. The removal efficiency was still as high as 97.5% even after six runs by magnetic separation of photocatalytic adsorbents after processing, indicating the reusability and high stability of the nanocomposites. These Fe3O4/Ag/POMs photocatalytic adsorbents with magnetic properties will hopefully become a functional material for wastewater treatment in the future.

12.
Molecules ; 24(17)2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31466314

RESUMO

The magnetic adsorbent, Fe3O4@[Ni(HL)2]2H2[P2Mo5O23]·2H2O (Fe3O4@1), is synthesized by employing the nanoparticles Fe3O4 and polyoxometalate hybrid 1. Zero-field-cooled (ZFC) and field-cooled (FC) curves show that the blocking temperature of Fe3O4@1 was at 120 K. Studies of Fe3O4@1 removing cationic and anionic dyes from water have been explored. The characterization of Fe3O4@1, effects of critical factors such as dosage, the concentration of methylene blue (MB), pH, adsorption kinetics, isotherm, the removal selectivity of substrate and the reusability of Fe3O4@1 were assessed. The magnetic adsorbent displayed an outstanding removal activity for the cationic dye at a broad range of pH. The adsorption kinetics and isotherm models revealed that the adsorption process of Fe3O4@1 was mainly governed via chemisorption. The maximum capacity of Fe3O4@1 adsorbing substance was 41.91 mg g-1. Furthermore, Fe3O4@1 showed its high stability by remaining for seven runs of the adsorption-desorption process with an effective MB removal rate, and could also be developed as a valuable adsorbent for dyes elimination from aqueous system.


Assuntos
Corantes/análise , Compostos Ferrosos/química , Compostos de Tungstênio/química , Adsorção , Concentração de Íons de Hidrogênio , Estrutura Molecular , Nanopartículas , Purificação da Água
13.
J Air Waste Manag Assoc ; 69(9): 1059-1069, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31050600

RESUMO

Xylene is the main component of many volatile industrial pollution sources, and the use of biotechnology to remove volatile organic compounds (VOCs) has become a growing trend. In this study, a biotrickling filter for gaseous xylene treatment was developed using activated sludge as raw material to study the biodegradation process of xylene. Reaction conditions were optimized, and long-term operation was performed. The optimal pH was 7.0, gas-liquid ratio was 15:1 (v/v), and temperature was 25 °C. High-throughput sequencing technique was carried out to analyze microbial communities in the top, middle, and bottom layers of the reactor. Characteristics of microbial diversity were elucidated, and microbial functions were predicted. The result showed that the removal efficiency (RE) was stable at 86%-91%, the maximum elimination capacity (EC) was 303.61 g·m-3·hr-1, residence time was 33.75 sec, and the initial inlet xylene concentration was 3000 mg·m-3, which was the highest known degradation concentration reported. Kinetic analysis of the xylene degradation indicated that it was a very high-efficiency-activity bioprocess. The rmax was 1059.8 g·m-3·hr-1, and Ks value was 4.78 g·m-3 in stationary phase. In addition, microbial community structures in the bottom and top layers were significantly different: Pseudomonas was the dominant genus in the bottom layer, whereas Sphingobium was dominant in the top layer. The results showed that intermediate metabolites of xylene could affect the distribution of community structure. Pseudomonas sp. can adapt to high concentration xylene-contaminated environments. Implications: We combined domesticated active sludge and reinforced microbial agent on biotrickling filter. This system performed continuously under a reduced residence time at 33.75 sec and high elimination capacity at 303.61 g·m-3·hr-1 in the biotrickling reactor for about 260 days. In this case, predomestication combined with reinforcing of microorganisms was very important to obtaining high-efficiency results. Analysis of microbial diversity and functional prediction indicated a gradient distribution along with the concentration of xylene. This implied a rational design of microbial reagent and optimizing the inoculation of different sites of reactor could reduce the preparation period of the technology.

14.
Nanomaterials (Basel) ; 9(4)2019 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-31018494

RESUMO

In this work, two magnetic adsorbents Fe3O4@1 and Fe3O4@2 were prepared by combining Fe3O4 nanoparticles and polyoxometalate hybrids [Ni(HL)2]2H2[P2Mo5O23]·4H2O (1), [H2L]5H[P2Mo5O23]·12H2O (2) (HL = 2-acetylpyridine-thiosemicarbazone). The temperature-dependent zero-field-cooled (ZFC) and field-cooled (FC) measurements indicated the blocking temperature at 160 K and 180 K, respectively. The Brunauer-Emmett-Teller (BET) surface area of Fe3O4@1 and Fe3O4@2 is 8.106 m2/g and 1.787 m2/g, respectively. Cationic dye methylene blue (MB) and anionic dye methyl orange (MO) were investigated for selective dye adsorption on Fe3O4@1 and Fe3O4@2. The two adsorbents were beneficial for selective adsorption of cationic dyes. The adsorption efficiency of MB was 94.8% for Fe3O4@1, 97.67% for Fe3O4@2. Furthermore, the two adsorbents almost maintained the same adsorption efficiency after seven runs. The maximum MB adsorption capacity of Fe3O4@1 and Fe3O4@2 is 72.07 and 73.25 mg/g, respectively. The fourier transform infrared (FT-IR) and X-ray photoelectron spectroscopy (XPS) spectra of the adsorbents collected after adsorption of MB are very similar to the initial as-synthesized Fe3O4@polyoxometalates indicating the high stability of the two adsorbents. The adsorption kinetics indicated that the MB removal followed the pseudo-second-order model. These results showed that the two adsorbents had a potential application in treating wastewater.

15.
Artigo em Inglês | MEDLINE | ID: mdl-30445292

RESUMO

In this work, a monolithic hydroxyethyl-based column was fabricated in a stainless-steel column (50 mm × 4.6 mm i.d.) via radical polymerization technique using hydroxyethyl methylacrylate as the monomer. The morphology and pore size distribution indicate that the optimized monolith has a relatively uniform structure with macro-pores. The homemade monolith was used as the stationary phase of high performance liquid chromatography for the separation of intact proteins from complex bio-samples, including human plasma, egg white and snailase. The resulting monolith shows excellent selectivity for intact proteins mainly depending on the different relative hydrophobicity of the objective proteins with reversed-phase liquid chromatographic mechanism. Besides, the hydrogen-bond interaction and electrostatic interaction were the additional interactions in the chromatographic separation owing to hydroxyl groups present in the surface of monolithic material.


Assuntos
Cromatografia Líquida de Alta Pressão/métodos , Metacrilatos/química , Proteínas/isolamento & purificação , Animais , Humanos , Ligações de Hidrogênio , Porosidade , Proteínas/química , Reprodutibilidade dos Testes , Eletricidade Estática
16.
Toxicol Res (Camb) ; 7(5): 987-993, 2018 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-30310676

RESUMO

Four metal complexes based on 2-benzoylpyridine N,N-dimethylthiosemicarbazone (Bp44mT) were designed. Free ligand and zinc(ii), diorganotin(iv), gallium(iii) and cadmium(ii) complexes all demonstrated pronounced activity, which was indicated using the growth inhibition test in vitro. Interestingly, most of the compounds were found to be selective against hepatocellular carcinoma (HepG2) cells but had little effect on normal hepatocyte (QSG7701) cells. In particular, Zn(Bp44mT)2 (1) exhibited toxicity on QSG7701 cells which approximately 12-fold lower than that on HepG2 cells. The studies of mechanisms of action indicated that 1 induced reactive oxygen species (ROS) generation in a dose-dependent manner via the mitochondria transduction pathway. Protein analyses showed that 1 significantly promoted p21 and p53 gene expression, causing caspase-3 activation.

17.
Nanomaterials (Basel) ; 8(9)2018 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-30201925

RESUMO

In this article, a study was presented on the adsorption activity of a new nanocomposite particle Fe3O4@1, which was synthesized by combining [Cu(HL)2]2H2[P2Mo5O23]·10H2O (1) (HL = 2-acetylpyridine semicarbazone) and Fe3O4 nanoparticles. Transmission electron microscopy and X-ray powder diffraction analyses revealed that Fe3O4@1 possessed high crystallinity with an average particle size of 19.1 nm. The adsorption activity of the as-prepared Fe3O4@1 was investigated by photometrically monitoring the removal of methylene blue, rhodamine B, safranine T, gentian violet, fuchsin basic, and methyl orange from aqueous solutions. Significantly, we could easily separate Fe3O4@1 from the reaction media by applying an external magnet. Furthermore, the recycling performance was observed using methylene blue, revealing the recyclability and high stability of Fe3O4@1. It was shown that Fe3O4@1 is a promising candidate material for adsorbing cationic dyes in aqueous media.

18.
Phys Chem Chem Phys ; 20(19): 13566-13573, 2018 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-29736503

RESUMO

Ta2N is an effective diffusion barrier material to prevent undesired Cu diffusion in ultra-large scale integration circuits. Previous theoretical work has reported the interesting result that at the Cu/Ta2N interface the Cu layer preferentially bonded with the Ta layer but not the N layer of Ta2N. However, this result was calculated from largely lattice mismatched interface models. To confirm this theoretical result and unravel the cause of strong Cu-Ta bonding at the Cu/Ta2N interface, in this study density functional theory calculations, on the basis of super-cell models, were performed to investigate the Cu(111)/Ta2N(001) interface. We firstly calculated interface cohesive energies and confirmed that the Cu layer preferentially bonded with the Ta layer of Ta2N. Then, electronic structure calculations revealed that the chemical bonding of the Cu-Ta bond at the Cu(111)/Ta2N(001) interface was primarily covalent in character, providing a proper explanation for the close integration of the Cu layer and Ta layer. Lastly, Cu diffusion investigations revealed that Ta2N was able to effectively prevent Cu diffusion. Furthermore, we found that the N layer of Ta2N played the critical role in preventing Cu diffusion.

19.
Dalton Trans ; 46(35): 11537-11541, 2017 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-28812076

RESUMO

A hydrophilic inorganic porous catalyst was prepared via the hydrothermal method. The combination of [WZn3(H2O)2(ZnW9O34)2]12- and Co(ii) provides a synergistical catalytic way to promote oximation of aldehyde/ketone with in situ generated hydroxylamine that initially produces an oxime, which further either dehydrates into a nitrile or undergoes a Beckmann rearrangement to form an amide.

20.
Amino Acids ; 49(8): 1355-1364, 2017 08.
Artigo em Inglês | MEDLINE | ID: mdl-28474125

RESUMO

Tumor chemotherapy is an important mean in the clinical treatment of metastatic cancer,but low selectivity and drug resistance restrict its clinical application. BP100 is a multifunctional membrane-active peptide with high antimicrobial activity. We selected BP100 as a lead peptide, designed and synthesized a series of BP100 analogs through solid-phase synthesis. Amongst them, peptides with the Tyr10 residue substituted by leucine and histidine showed the highest anti-cancer activity. Further experiments revealed that BP100 and its analogs could disrupt the cell membrane and trigger the cytochrome C release into cytoplasm, which ultimately resulted in apoptosis. Meanwhile, BP100 and its analogs also exhibited effective anti-tumor activity against multidrug-resistant cells, showing multidrug resistance-reversing effects. In conclusion, these peptides might be promising candidates for cancer therapy.


Assuntos
Antineoplásicos/síntese química , Antineoplásicos/farmacologia , Desenho de Drogas , Resistência a Múltiplos Medicamentos/efeitos dos fármacos , Neoplasias/patologia , Oligopeptídeos/farmacologia , Apoptose/efeitos dos fármacos , Membrana Celular/efeitos dos fármacos , Membrana Celular/metabolismo , Proliferação de Células/efeitos dos fármacos , Humanos , Mitocôndrias/efeitos dos fármacos , Neoplasias/tratamento farmacológico , Oligopeptídeos/síntese química , Técnicas de Síntese em Fase Sólida , Células Tumorais Cultivadas
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