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1.
J Colloid Interface Sci ; 581(Pt B): 709-718, 2021 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-32814194

RESUMO

A one-pot solvothermal strategy and subsequent calcination were proposed for fabricating a composite of NiO nanoparticles on hexagonal Ni-based metal-organic framework (Ni-MOF) (Ni-MOF@NiO). The prepared NiO nanoparticles on the hexagonal Ni-MOF not only improves the electrical conductivity and increases redox active sites, but also prevents the agglomeration of NiO nanoparticles. In particular, highly dispersed and small-sized NiO nanoparticles on the hexagonal Ni-MOF facilitates the migration of electrolyte ions, and the pseudocapacitive performance is evaluated through electrochemical measurements. At 0.5 A g-1, the Ni-MOF@NiO composite shows a specific capacitance of up to 1192.7 F g-1 and a high capacity retention (93.23% over 5000 cycles) in 3 M KOH. Moreover, the Ni-MOF@NiO nanoparticles and activated carbon are assembled into aqueous devices with a maximum energy density of 62.2 Wh kg-1. These results indicate the potential of Ni-MOF@NiO composite as an electrode material for application in supercapacitors. Additionally, the method of synthesizing Ni-MOF@NiO in this study can be used to synthesize other MOF@metal oxide materials for electrochemical energy storage and other related applications.

2.
Integr Med Res ; 10(1): 100486, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32837905

RESUMO

Background: Squama Manitis (pangolin scale) has been used in traditional Chinese medicine for thousands of years. However, its efficacy has not been systematically reviewed. This review aims to fill the gap. Methods: We searched six electronic databases including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure Database (CNKI), WanFang Database and SinoMed from inception to May 1, 2020. Search terms included "pangolin", "Squama Manitis", "Manis crassicaudata", "Manis javanica", "Malayan pangolins", "Manis pentadactyla", "Ling Li", "Chuan Shan Jia", "Shan Jia", "Pao Jia Zhu", "Jia Pian" and "Pao Shan Jia". The Cochrane Risk of Bias (RoB) assessment tool and Newcastle-Ottawa Scale (NOS) were used to evaluate the risk of bias of the included randomized controlled trials (RCTs) and case control studies (CCSs). Results: After screening, 15 articles that met the inclusion criteria were finally included. There were 4 randomized controlled trials, 1 case control study, 3 case series and 7 case reports. A total of 15 different diseases were reported in these studies, thus the data could not be merged to generate powerful results. Two RCTs suggested that Squama Manitis combined with herbal decoction or antibiotics could bring additional benifit for treating postpartum hypogalactia and mesenteric lymphadenitis. However, this result was not reliable due to low methodological quality and irrational outcomes. The other two RCTs generated negative results. All the non-RCTs did not add any valuable evidence to the efficacy of Squama Manitis beacause of small samples, incomplete records, non-standardized outcome detection. In general, currently available evidence cannot support the clinical use of Squama Manitis. Conclusion: There is no reliable evidence that Squama Manitis has special medicinal value. The removal of Squama Manitis from Pharmacopoeia is rational.

3.
J Environ Sci (China) ; 99: 260-266, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33183703

RESUMO

Metal phthalocyanine has been extensively studied as a catalyst for degradation of carbamazepine (CBZ). However, metal phthalocyanine tends to undergo their own dimerization or polymerization, thereby reducing their activity points and affecting their catalytic properties. In this study, a catalytic system consisting of O-bridged iron perfluorophthalocyanine dimers (FePcF16-O-FePcF16), multi-walled carbon nanotubes (MWCNTs) and H2O2 was proposed. The results showed MWCNTs loaded with FePcF16-O-FePcF16 can achieve excellent degradation of CBZ with smaller dosages of FePcF16-O-FePcF16 and H2O2, and milder reaction temperatures. In addition, the results of experiments revealed the reaction mechanism of non-hydroxyl radicals. The highly oxidized high-valent iron-oxo (Fe(IV)=O) species was the main reactive species in the FePcF16-O-FePcF16/MWCNTs/H2O2 system. It is noteworthy that MWCNTs can improve the dispersion of FePcF16-O-FePcF16, contributing to the production of highly oxidized Fe(IV)=O. Then, the pathway of CBZ oxidative degradation was speculated, and the study results also provide new ideas for metal phthalocyanine-loaded carbon materials to degrade emerging pollutants.


Assuntos
Ferro , Nanotubos de Carbono , Carbamazepina , Peróxido de Hidrogênio , Oxirredução
4.
Biomaterials ; 265: 120456, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33099066

RESUMO

External stimuli-responsive nanomedicine with desirable repetitive on-demand drug release character is postulated to greatly accommodate patients' flexible medication regime. To this object, light-activatable liposomes (Pt/Ce6-LP) integrated with both a Ce6 photodynamic component and a tetravalent platinum prodrug (Pt(IV)) chemotherapeutic component are engineered. This multifunctional system was rationally designed using unsaturated phospholipid to achieve repetitive on-demand drug release under discontinuous light irradiation, thus performing chemo-photodynamic therapy effect and immunopotentiation in hypoxic tumor. Furthermore, glutathione (GSH) consumption during transformation from Pt(IV) prodrug to Pt(II) can avoid depletion of reactive oxygen species (ROS) in photodynamic therapy (PDT). Note this positive feedback loop appears to remodel the redox balance of H2O2 and GSH in tumors, alleviating the hypoxic tumor microenvironment. The alleviated hypoxia is found to be critical to the enhancement of PDT efficacy, reversal of cisplatin resistance in tumors, and polarization of tumor-associated macrophages (TAMs) to the immunocompetent M1-phynotype. Pt/Ce6-LP with light radiation demonstrates significant antitumor effect and persistent post-medication inhibition in patient-derived tumor xenograft model of hepatocellular carcinoma.

5.
Sci Total Environ ; 753: 142021, 2021 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-32898810

RESUMO

Membrane filtration electrode based microbial fuel cell provides a promising route to simultaneously recover energy and produce high-quality effluent during water treatment. Enhancing effluent quality and oxygen reduction reaction (ORR) activity of the membrane electrode still remains a major challenge. In this study, filtration types of membrane electrodes with Prussian blue (PB) doping and PVDF-PVC-PEG triblock copolymers were prepared by a simple phase inversion fabrication process. The PB-0.2 membrane electrode with optimal 0.2 wt% of PB obtained the highest current density (12.0 A m-2) and the lowest charge transfer resistance (5.0 ± 0.1 Ω). Rotating disk electrode (RDE) results also demonstrated that the PB-0.2 catalyst exhibited the superior ORR activity with the highest number of transferred electrons (n = 3.90). Furthermore, the MFC with PB-0.2 produced the maximum power density of 1401 ± 17 mW m-2, which was 186.5% higher than that of the control. Moreover, the filtrated effluent tCODeff was 20.6 ± 1.2 mg L-1 for the PB-0.2, which was significantly reduced by 63% compared with the control. These results showed that the addition of PB was an effective strategy to enhance the overall oxygen reduction performance and improve effluent quality of microbial fuel cells.


Assuntos
Fontes de Energia Bioelétrica , Eletrodos , Ferrocianetos , Oxigênio
6.
Support Care Cancer ; 29(1): 193-201, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32337626

RESUMO

PURPOSE: Evidence suggests that fruit and vegetable consumptions may improve mental health among general population. However, their associations among breast cancer survivors are unclear. We planned to investigate this association via a nationwide survey in the USA. METHODS: We identified 7988 breast cancer survivors from 2009 Behavioral Risk Factor Surveillance System (BRFSS). Fruit juice, fruit, and vegetable consumptions were categorized as ordinal variables to approximate tertiles. Survivors who were mentally unhealthy for at least 14 days in the past 30 days were defined as having frequent mental distress (FMD). Multivariable logistic regression treating FMD as the outcome was used to calculate adjusted odd ratios (aORs) and 95% confidence intervals (CIs) for exposures. Quadratic model was used to depict the dose-response pattern in primary analysis. Subgroup analyses by adverse lifestyle behaviors were conducted; Wald tests were used to examine if there were interactions between these factors and exposures in relation to FMD. RESULTS: Overall, 825 (10.3%) survivors had FMD. Mean age was 67.2 years, and 89.7% of survivors were white. Juice showed non-significant associations with FMD. Moderate (aOR = 0.81, 95% CI = 0.68-0.98) and high (aOR = 0.79, 95% CI = 0.63-0.98) fruit consumptions, as well as moderate vegetable consumption (aOR = 0.78, 95% CI = 0.64-0.94), were significantly and inversely associated with FMD. The dose-response curves were consistent with results in primary analysis. No interaction was identified for adverse lifestyle behaviors. CONCLUSION: Fruit and vegetable, but not fruit juice, show potential preventive effects against FMD among breast cancer survivors. The conclusion should be verified by studies with clear temporality in future.

7.
Sci Total Environ ; 753: 141809, 2021 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-33207450

RESUMO

In recent years, the safety and ecology threat of cyanobacterial burst has drawn wide concern, especially the release of toxic microcystin-LR (MC-LR). To break through the bottleneck of uncomplete MC-LR degradation by conventional physical-chemistry methods, Fenton-based advanced oxidation processes (AOPs) developed rapidly due to striking degradation efficiency through the potent hydroxyl radicals (HO·) oxidation. Herein, a comprehensive overview is presented on the recent achievements of the various Fenton-based technologies (including conventional Fenton, photo-Fenton, electro-Fenton, ozone-Fenton and sono-Fenton) for MC-LR degradation. In particular, the comparisons between various Fenton-based technologies about advantages and drawbacks are discussed. Based on analyzing the degradation intermediates and pathways, the destruction of Adda chain via hydroxylation was confirmed to be essential for detoxification of MC-LR. Roles of influencing factors such as MC-LR initial concentration, dosages of the catalyst and oxidant, environment alkalinity, natural organic matters (NOMs) as well as other inorganic ions are specifically summarized. This Review also gave special emphasis on technique optimization trends for Fenton application of MC-LR degradation, as well as key challenges and future opportunities in this fast developing field.


Assuntos
Ozônio , Purificação da Água , Microcistinas , Oxirredução
8.
J Mol Histol ; 2020 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-33159638

RESUMO

As the major receptor mediated BMP signaling in craniofacial development, Bmpr1a expression was detected in the anterior palatal shelves from E13.5 and the posterior palatal shelves from E14.5. However, inactivating BMP receptor in the mesenchyme only leads to anterior cleft palate or submucous cleft palate. The role of BMP signaling in posterior palatal mesenchyme and palatal osteogenesis is still unknown. In this study, a secreted BMP antagonist, Noggin was over-expressed by Osr2-creKI to suppress BMP signaling intensively in mouse palatal mesenchyme, which made the newborn mouse displaying complete cleft palate, a phenotype much severer than the anterior or submucous cleft palate. Immunohistochemical analysis indicated that in the anterior and posterior palatal mesenchyme, the canonical BMP-Smad4 signaling was dramatically down-regulated, while the non-canonical BMP signaling pathways were altered little. Although cell proliferation was reduced only in the anterior palatal mesenchyme, the osteogenic condensation and Osterix distribution were remarkably repressed in the posterior palatal mesenchyme by Noggin over-expression. These findings suggested that BMP-Smad4 signaling was essential for the cell proliferation in the anterior palatal mesenchyme, and for the osteogenesis in the posterior palatal mesenchyme. Interestingly, the constitutive activation of Bmpr1a in palatal mesenchyme also caused the complete cleft palate, in which the enhanced BMP-Smad4 signaling resulted in the premature osteogenic differentiation in palatal mesenchyme. Moreover, neither the Noggin over-expression nor Bmpr1a activation disrupted the elevation of palatal shelves. Our study not only suggested that BMP signaling played the differential roles in the anterior and posterior palatal mesenchyme, but also indicated that BMP-Smad4 signaling was required to be finely tuned for the osteogenesis of palatal mesenchyme.

9.
Sci Total Environ ; : 143076, 2020 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-33129535

RESUMO

Vivianite (Fe3(PO4)2·8H2O) is a common hydrous ferrous phosphate mineral which often occurs in reductive conditions, especially anoxic non-sulfide environment containing high concentrations of ferrous iron (Fe2+) and orthophosphate (PO43-). Vivianite is an important product of dissimilatory iron reduction and a promising route for phosphorus recovery from wastewater. Its formation is closely related to the extracellular electron transfer (EET), a key mechanism for microbial respiration and a crucial explanation for the reduction of metal oxides in soil and sediments. Despite of the natural ubiquity, easy accessibility and attractive economic value, the application value of vivianite has not received much attention. This review introduces the characteristics, occurrence and biosynthesis of vivianite from microbial EET, and systematically analyzes the application value of vivianite in the environmental field, including immobilization of heavy metals (HMs), dechlorination of carbon tetrachloride (CT), sedimentary phosphorus sequestration and eutrophication alleviation. Additionally, its potential functions as a slow-release fertilizer are discussed as well. In general, vivianite is expected to make more contributions to the future scientific research, especially the solution of environmental problems. Overcoming the lack of understanding and some technical limitations will be beneficial to the further application of vivianite in environmental field.

10.
J Craniofac Surg ; 31(8): 2193-2198, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33136853

RESUMO

The aim of this study is to evaluate the osteogenesis around titanium implant and in bone defect or fracture in jaw bones and long bones in ovariectomized (OVX) animal models. The literature on the osteogenesis around titanium implant and in bone defect or fracture in jaw bones and long bones was reviewed with charts. Fourty-eight rats were randomly divided into OVX group with ovariectomy and SHAM (sham-surgery) group with sham surgery. Titanium implants were inserted in the right mandibles and tibiae; bone defects were created in the left mandibles and tibiae. Two-week postoperatively, mandibles and tibiae of 8 rats were harvested and examined by hematoxylin and eosin staining and histological analysis; 4-week postoperatively, all mandibles and tibiae were harvested and examined by Micro-CT and histological analysis. A total of 52 articles were included in this literature review. Tibial osteogenesis around titanium implant and in bone defect in OVX group were significantly decreased compared with SHAM group. However, osteogenesis differences in the mandible both around titanium implant and in bone defect between groups were not statistically significant. OVX-induced osteoporosis suppresses osteogenesis around titanium implant and in the bone defect or fracture in long bones significantly while has less effect on that in the jaw bones.

11.
Artigo em Inglês | MEDLINE | ID: mdl-33139019

RESUMO

Hydrogen peroxide (H2O2) is a significant biomarker in physiological processes. Abnormal levels of H2O2 are considered to be closely related to some acute diseases. Therefore, it is important to monitor the H2O2 levels in bio-samples. Herein, we present a novel non-enzymatic electrochemical H2O2 sensor based on the excellent electrocatalytic performance of a composite comprising Zn-Cr-Co ternary spinel metal oxide nanodots (ZnCrCoO4) anchored on the surface of nitrogen-doped carbon nanotubes (NCNTs), denoted as ZnCrCoO4/NCNTs, toward H2O2 reduction. ZnCrCoO4/NCNTs were synthesized using a facile one-pot hydrothermal strategy. The enhanced electrocatalytic performance of ZnCrCoO4 is resulted from the partial substitution of Co in spinel zinc cobaltate (ZnCo2O4) with Cr, which modifies the CoO electronic structure and enhances electroconductivity. The ZnCrCoO4/NCNTs-based H2O2 sensor exhibited a wide quantitative detection range from 1 to 7330 µM with a detection limit of 1 µM. The sensor showed excellent reproducibility and selectivity for H2O2 sensing. In addition, remarkable recoveries were obtained for H2O2-spiked fish serum samples. These results demonstrated that the as-developed sensor has a great potential in monitoring H2O2 levels in practical applications.

12.
Nano Lett ; 20(11): 8141-8150, 2020 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-33172280

RESUMO

The ferroptosis effect has been illuminated with a clear Fenton reaction mechanism that converts endogenous hydrogen peroxide (H2O2) into highly oxidative hydroxyl radicals (·OH) in ROS-amplified tumor therapy. This ferroptosis-related oxidation effect was then further enhanced by the enzyme-like roles of cisplatin (CDDP). This CDDP-induced apoptosis was promoted in reverse by ferroptosis via the depletion of glutathione (GSH) and prevention of DNA damage repair. Here, we have developed degradable metallic complexes (PtH@FeP) containing an Fe(III)-polydopamine (FeP) core and HA-cross-linked CDDP (PtH) shell, exaggerating in situ toxic ROS production via the synergistic effect of CDDP and Fe(III). Taken together, the rationally designed PtH@FeP provided a new strategy for self-amplified synergistic chemotherapy/ferroptosis/photothermal therapy (PTT) antitumor effects with a reduced dosage that facilitates clinical safety.

13.
Mol Ther ; 2020 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-33221434

RESUMO

Patients with hereditary tyrosinemia type I (HT1) present acute and irreversible liver and kidney damages during infancy. CRISPR/Cas9-mediated gene correction during infancy may provide a promising approach to treat patients with HT1. However, all previous studies were performed on adult HT1 rodent models, which cannot authentically recapitulate some symptoms of human patients. To translate precise gene therapy to clinical practice, the efficacy and safety should be verified in large animals. Here, we delivered CRISPR/Cas9 and donor templates via adeno-associated virus to newborn HT1 rabbits. The lethal phenotypes could be rescued, and notably, these HT1 rabbits reached adulthood normally without 2-(2-nitro-4-trifluoromethylbenzyol)-1,3 cyclohexanedione administration, and even gave birth to offspring. AAV-treated HT1 rabbits displayed normal liver and kidney structures and functions. Homology-directed repair-mediated precise gene corrections and non-homologous end joining-mediated out-of-frame to in-frame corrections in the livers were observed with efficiencies of 0.90%-3.71% and 2.39%-6.35%, respectively, which appeared to be sufficient to recover liver function and decrease liver and kidney damages. This study provides useful large-animal preclinical data for rescuing hepatocyte-related monogenetic metabolic disorders with precise gene therapy.

14.
Thorac Cancer ; 2020 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-33210466

RESUMO

BACKGROUND: 99m Tc bone scintigraphy (BS) is still the most common approach for the evaluation of bone metastasis in China. The purpose of this study was to investigate the necessity of BS as part of a routine preoperative workup for patients with cT1N0 subsolid lung cancer. METHODS: This was a prospective multicenter clinical trial (NCT03689439). Patients with cT1N0 subsolid nodules who were candidates for surgical resection were consecutively enrolled into the study. BS was performed preoperatively. The surgical plan could be changed if a positive result was detected. The primary endpoint was the incidence rate of the surgical plan being changed because of positive BS results. The secondary endpoint was the rate of positive BS findings and the rate of related complications. RESULTS: From November 2018 to July 2019, 691 patients were enrolled into the study. None of the patients had positive BS results and no surgical plans were changed by BS findings. There were 222 male and 469 female patients. The average age was 54.8 ± 3.7 years old. The average tumor diameter was 14.9 ± 4.2 mm. There were 282 patients with pure GGO nodules and 409 with part-solid nodules. A total of 470 patients had a single nodule, while 221 patients had multifocal lesions. The number of patients whose pathological diagnosis was invasive adenocarcinoma, minimally invasive adenocarcinoma, adenocarcinoma in situ and mucinous adenocarcinoma was 357, 293, 32 and nine, respectively. The number of patients who underwent lobectomy, segmentectomy and wedge resection was 234, 199 and 258, respectively. CONCLUSIONS: 99m Tc bone scintigraphy is unnecessary in the preoperative workup for patients with cT1N0 subsolid lung cancer. KEY POINTS: SIGNIFICANT FINDINGS OF THE STUDY: In this prospective study of 691 patients with cT1N0 subsolid lung cancer, no surgical plans were affected by positive bone scan findings. WHAT THIS STUDY ADDS: We suggest physicians consider canceling BS from preoperative workup for cT1 subsolid lung cancer patients. Clinical trial registry number: NCT03689439.

15.
Mediators Inflamm ; 2020: 8414062, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33223957

RESUMO

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are challenging diseases with the high mortality in a clinical setting. Baicalin (BA) is the main effective constituent isolated from the Chinese medical herb Scutellaria baicalensis Georgi, and studies have proved that it has a protective effect on ALI induced by lipopolysaccharide (LPS) due to the anti-inflammatory efficacy. However, BA has low solubility which may limit its clinical application. Hence, we prepared a novel drug delivery system-Baicalin liposome (BA-LP) in previous research-which can improve some physical properties of BA. Therefore, we aimed to explore the effect of BA-LP on ALI mice induced by LPS. In pharmacokinetics study, the values of t 1/2 and AUC0- t in the BA-LP group were significantly higher than that of the BA group in normal mice, indicating that BA-LP could prolong the duration time in vivo of BA. The BA-LP group also showed a higher concentration in lung tissues than the BA group. Pharmacodynamics studies showed that BA-LP had a better effect than the BA group at the same dosage on reducing the W/D ratio, alleviating the lung injury score, and decreasing the proinflammatory factors (TNF-α, IL-1ß) and total proteins in bronchoalveolar lavage fluids (BALF). In addition, the therapeutic effects of BA-LP showed a dose-dependent manner. Western blot analysis indicated that the anti-inflammatory action of BA could be attributed to the inhibition of the TLR4-NFκBp65 and JNK-ERK signaling pathways. These results suggest that BA-LP could be a valuable therapeutic candidate in the treatment of ALI.

16.
J Sep Sci ; 2020 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-33216431

RESUMO

Polyethyleneimine-modified magnetic multi-walled carbon nanotubes were developed to extract 10 mycotoxins. Simple modification of polyethyleneimine was achieved on the magnetic substrate by using an epoxy-containing silane agent as a linker. The resultant magnetic adsorbent was integrated with reverse phase and anion exchange interaction sites. Under optimal extraction conditions, only 20.0 mg adsorbent was used to extract the mycotoxins from 50.0 mL loading solution. The maximum adsorption capacities of the adsorbent toward the mycotoxins ranged from 4.9 mg g-1 to 10.2 mg g-1 . Adsorption and desorption were completed within 3.0 min and 2.0 min, respectively. The adsorbent could be used for six repeated runs without evident change in extraction performance. The adsorbent combined with LC-MS/MS was applied further to analyze the mycotoxins in milk. The absolute recoveries of the 10 mycotoxins ranged from 88.3% to 103.5% with relative standard deviations that ranged from 2.4% to 6.5%, and their limits of detection were 0.003 µg kg-1 to 0.442 µg kg-1 . The proposed adsorbent has great potential in the routine analysis of mycotoxins in ordinary analytical chemistry laboratory. This article is protected by copyright. All rights reserved.

17.
Nanotechnology ; 2020 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-33176292

RESUMO

The mechanism of nanofiltration (NF) membrane separation of Mg2+ and Li+ needs to be further investigated, but some commonly used model theories are abstract, which makes them difficult to understand. More importantly, the relationship between membrane charge and separation performance of Mg2+ and Li+ cannot be quantitatively analyzed. It is worth to study those challenges and provide a performance boost for Mg2+/Li+ filtration applications of NF membranes. Here, various NF membranes with the membrane volumetric charge density increasing from -4.69 to 7.02 mol•m-3 were fabricated via interfacial polymerization. For these membranes, the separation factor SMg,Li were decreased from 0.41 to 0.20. Importantly, the visual simulation results were consistent with the experimental results as a whole. The separation factor SMg,Li decreased with the increase of volumetric charge density, and the minimum separation factor SMg,Li of NF membranes was 0.20 (experiment) and 0.17 (simulation), respectively. This manifested that the performance of positive charged NF membrane had not fully been developed. Furthermore, we analyzed further the relationship between membrane charge and separation performance, and visualized the simulation of NF membrane filtration and separation.

18.
Mikrochim Acta ; 187(12): 648, 2020 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-33165743

RESUMO

An amphiphilic block copolymer consisting of poly(N-acryloyl-glucosamine) (PAGA) and poly(tert-butyl methacrylate) (PtBMA) was designed and grafted on magnetic multi-walled carbon nanotubes (Fe3O4MWCNTs). The resultant Fe3O4MWCNTs@copolymer was proposed as QuEChERS adsorbent for determination of 15 mycotoxins and 25 pesticides in grains via liquid chromatography tandem mass spectrometry. The adsorbent was characterized by a transmission electron microscope, scanning electron microscope, elemental analysis, and other techniques. The common matrix interferences were efficiently removed by the proposed adsorbent, such as pigment, fatty acids, and the saccharide. PAGA segment played an important role in removing the hydrophilic interferences through hydrogen bonding due to the high density of hydroxyl groups. PtBMA segment removed the fatty residues through its strong hydrophobic carbon moiety. In comparison with the commercially available QuEChERS adsorbents, the proposed adsorbent had higher adsorption capacities towards the typical matrix interferences. To achieve satisfactory recoveries of analytes, various parameters in the QuEChERS procedure were comprehensively investigated. Under the optimal conditions, 95.0% of the analytes showed satisfactory recoveries in the range 70.0-120% as well as negligible matrix effects. The limits of detection (LOD) were in the range 0.00015-1.3 µg kg-1. Compared with previously reported QuEChERS methods, the proposed method had improved sensitivity and benefited from low matrix effects. The recoveries of analytes in various grains were in the range 60.8-108% with relative standard deviations (RSD) less than 13%. Moreover, the Fe3O4MWCNTs@copolymer exhibited good synthetic reproducibility and rapid magnetic separation (less than 10 s). The research provides a versatile platform to develop multi-functional QuEChERS adsorbents based on the amphiphilic block copolymer.

19.
BMC Musculoskelet Disord ; 21(1): 730, 2020 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-33172443

RESUMO

PURPOSE: Muscle strength training is a common strategy for treating chronic ankle instability (CAI), but the effectiveness decreases for mechanical ankle instability (MAI) patients with initial severe ligament injuries. The purpose of this study was to investigate the characteristics and the potential predictors of muscle strength deficit in MAI patients, with a view to proposing a more targeted muscle strength training strategy. METHODS: A total of 220 MAI patients with confirmed initial lateral ankle ligament rupture and a postinjury duration of more than 6 months were included. All patients underwent a Biodex isokinetic examination of the ankle joints of both the affected and unaffected sides. Then, the associations between the limb symmetry index (LSI) (mean peak torque of the injury side divided by that of the healthy side) and the patients' sex, body mass index, postinjury duration, presence of intra-articular osteochondral lesions, presence of osteophytes and ligament injury pattern (i.e., isolated anterior talofibular ligament (ATFL) injury or combined with calcaneofibular ligament injury) were analysed. RESULTS: There was significantly weaker muscle strength on the affected side than on the unaffected side in all directions (p < 0.05). The LSI in plantar flexion was significantly lower than that in dorsiflexion at 60°/s (0.87 vs 0.98, p < 0.001). A lower LSI in eversion was significantly correlated with female sex (0.82 vs 0.94, p = 0.016) and isolated ATFL injury (0.86 vs 0.95, p = 0.012). No other factors were found to be associated with muscle strength deficits. CONCLUSION: MAI patients showed significant muscle strength deficits on the affected side, especially in plantar flexion. There were greater strength deficits in eversion in females and individuals with an isolated ATFL injury. Thus, a muscle strength training programme for MAI patients was proposed that focused more on plantar flexion training and eversion training for females and those with an isolated ATFL injury.

20.
Epilepsy Behav ; 113: 107571, 2020 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-33242773

RESUMO

PURPOSE: Our aims were to determine (1) whether the marriage rate was different between the sexes and (2) whether the influencing factors of marital status varied by sexes. METHODS: A cross-sectional study was performed among 475 people with epilepsy (PWE) in Northeast China. The demographic information and clinical data were gathered and recorded. Sex differences in the marriage rate of PWE and the related influencing factors were analyzed. Multivariate logistic regression analyses were used to investigate the independent factors influencing marital status in men and women, respectively. RESULTS: Among 475 participants, 219 (79.6%) men with epilepsy (MWE) were married, and 140 (70%) women with epilepsy (WWE) were married. In MWE, age, educational level, age at seizure onset, and disease duration were significantly different between the married men and the single men. In WWE, age, educational level, occupation and age at seizure onset showed significant differences between the married women and the single women. In the multiple logistic regression model, age and age at first seizure onset had an independent effect on the marital status in men with epilepsy. Multiple logistic regression analysis also revealed that age and age at first seizure onset were independent factors that influenced marital status in WWE. CONCLUSION: Men with epilepsy were more likely to marry than WWE. Age and the age of seizure onset independently affected the marital status of men and women.

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