Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 15 de 15
Filtrar
Mais filtros










Base de dados
Tipo de estudo
Intervalo de ano de publicação
1.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 28(1): 314-319, 2020 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-32027295

RESUMO

OBJECTIVE: To study the epidemiologic characteristics of human herpes virus (HHV) activated infection in the diseases of blood system and patients received allo-HSCT by statistically analyzing the screening results of 8 human herpes viruses (HHVs) of 4164 patients in Hebei Yanda LU Dao-Pei Hospital from 2012 to 2017. METHODS: PCR was used to screen 8 HHVs. RESULTS: Two thousand and fifty-two patients (49.28%) were HHV-positive among 4164 patients screened. Among these patients screened, the infection spectra of 8 human HHVs in hematological diseases as well as patients received allogeneic hematopoietic stem cell transplantation of totally 2994 patients were summarized as follows: the positive rate of EBV (29.49%) was the highest, that of HCMV (23.15%), HHV-6 was 18.77% and HHV-7 was 17.64%, while the remaining 4 HHVs all≤2.1%. The rate of co-infection of various HHVs was significantly higher than that of single infection of HHV among all these disease groups except familial hemophagocytic lymphohistiocytosis, for which single EBV infection was the most common. The differences of positive rates among these 8 human HHVs in hematological diseases as well as patients received allogeneic hematopoietic stem cell transplantation were statistically significant by Chi-square test of R*C tables (χ2=54.99, P<0.05). For each HHV, the differences of positive rates among the above-mentioned disease groups were also statistically significant except HHV-8 (P<0.05). CONCLUSION: The patients with various blood diseases have different activated infection spectra of HHVs. EBV, HCMV, HHV-6 and HHV-7 are most common in HHVs infection. Different HHVs infections correlate with different hematologion diseases.


Assuntos
Infecções por Vírus Epstein-Barr , Transplante de Células-Tronco Hematopoéticas , Infecções por Herpesviridae , Síndromes de Imunodeficiência , DNA Viral , Humanos
2.
Soft Matter ; 15(41): 8197-8200, 2019 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-31613305

RESUMO

A series of supramolecular assemblies based on multi-charged calixarene (SC4A), bis(p-calixarene) (BSC4A) and pillararene (CP5A) modified gold nanoparticles (AuNP) was constructed to realize colorimetric sensing of both succinylcholine (SuCh) and butyrylcholinesterase (BChE). With the high binding affinity of BSC4A and CP5A towards SuCh, BSC4A-AuNPs and CP5A-AuNPs could assemble with micromolar level SuCh as SuCh-BSC4A/CP5A-AuNPs. More interestingly, the enzymatic hydrolysis of SuCh by BChE could lead to the disassembly of SuCh-BSC4A/CP5A-AuNPs and provide a sensitive time-dependent color change from blue to red which could be observed by the naked eye and used to monitor BChE activity. As BChE activity is an important biomarker for diseases and poor health conditions, this novel supramolecular tandem colorimetric sensing strategy may have potential use for early diagnosis of diseases.

3.
Chem Commun (Camb) ; 55(78): 11790-11793, 2019 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-31524903

RESUMO

Balancing and neutralizing heparin dosing after surgeries and hemodialysis treatment is of great importance in medical and clinical fields. In this study, a series of new amphiphilic multi-charged cyclodextrins (AMCD)s as anti-heparin coagulants were designed and synthesized. The AMCD assembly was capable of selective heparin binding through multivalent bonding and showed a better neutralizing effect towards both unfractionated heparin and low molecular weight heparin than protamine in plasma. Meanwhile, an AMCD and vitamin K (VK) co-assembly was prepared to realize heparin-responsive VK release and provide a novel VK deficiency treatment for hemodialysis patients. This AMCD-VK co-assembly for heparin neutralization & vitamin K supplementation synergistic coagulation represents a promising candidate as a clinical anti-heparin coagulant.


Assuntos
Coagulantes/química , Ciclodextrinas/química , Vitamina K/química , Coagulantes/metabolismo , Ciclodextrinas/metabolismo , Heparina/química , Heparina/metabolismo , Tempo de Tromboplastina Parcial , Protaminas/química , Protaminas/metabolismo , Espectrofotometria , Vitamina K/metabolismo
4.
Chem Commun (Camb) ; 55(31): 4499-4502, 2019 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-30919856

RESUMO

A snowflake-like supramolecular clockwise-helical assembly was fabricated via the host-guest interaction of trans-azobenzene-bridged bis(dibenzo-24-crown-8) (trans-1) and a cholesterol derivative, while a snowflake-like supramolecular non-helical assembly can be obtained upon complexation of cis-1 after UV-irradiation, accompanying the disappearance of circular dichroism signals from the azobenzene zone of 1.

5.
Materials (Basel) ; 11(7)2018 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-29949898

RESUMO

In this work, the surface morphology of a hydrophobic organosilicon film was modified as it was deposited onto a silver seed layer with nanoparticles. The surface hydrophobicity evaluated by the water contact angle was significantly increased from 100° to 128° originating from the surface of the organosilicon film becoming roughened, and was deeply relevant to the Ag seed layer conform deposition. In addition, the organosilicon film became surface oleophobic and the surface hydrophobicity was improved due to the formation of the inactive C-F chemical on the surface after the carbon tetrafluoride glow discharge etching. The surface hydrophobicity and oleophobicity of the organosilicon film could be further optimized with water and oleic contact angles of about 138° and 61°, respectively, after an adequate fluorination etching.

6.
Chem Commun (Camb) ; 53(26): 3717-3720, 2017 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-28300240

RESUMO

A novel supramolecular assembly was constructed by the noncovalent complexation of hexa-cata-hexabenzocoronene modified permethyl-ß-cyclodextrins with tetrasodium tetraphenylporphyrintetrasulfonate in water, exhibiting highly efficient excited energy transfer behaviors and a promising DNA photocleavage ability.


Assuntos
Clivagem do DNA/efeitos da radiação , Transferência de Energia , Luz , Fármacos Fotossensibilizantes/química , Compostos Policíclicos/química , Porfirinas/química , beta-Ciclodextrinas/química
7.
Transfus Apher Sci ; 55(2): 194-200, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27665154

RESUMO

BACKGROUND: Accumulating evidence has shown that ambient exposure to PM2.5, especially in the haze weather, increased the risk of various diseases. However, the association of air pollution status with blood transfusion utilization and the prevalence and severity of adverse transfusion reactions remain to be clarified. MATERIALS AND METHODS: The data of monthly transfusion usage of blood components, adverse transfusion reactions, as well as PM2.5 and PM10 levels from 2013 to 2015 were obtained. RESULTS: During the study interval, both PM2.5 and PM10 levels were significantly increased in the haze weather when compared with the non-haze weather. The utilization of total blood components per patient-month in the haze weather was prone to be increased when compared with that in the non-haze weather (13.28 ± 1.66 vs. 12.33 ± 1.30, p = 0.068). The usage of RBC products per patient-month in the haze weather was significantly increased when compared with that in the non-haze weather (4.39 ± 0.39 vs. 4.07 ± 0.30, p = 0.009). There was no obvious difference between the haze and non-haze weathers for the usage of platelet and plasma products per patient-month. Besides, no definite differences of the prevalence and severity of transfusion-associated adverse reaction were observed between the haze and non-haze weathers. CONCLUSION: Our study first indicated that transfusion utilization, particularly the RBC products, was significantly increased in the haze weather when compared with that in the non-haze weather. There was no obvious association of air pollution with the prevalence and severity of adverse transfusion reactions and further research is required.


Assuntos
Transfusão de Componentes Sanguíneos/efeitos adversos , Material Particulado/efeitos adversos , Tempo (Meteorologia) , Feminino , Humanos , Masculino , Estudos Retrospectivos
8.
Tumour Biol ; 37(10): 13333-13343, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27460081

RESUMO

Liposarcoma(LPS) is the most common type of soft tissue sarcoma accounting for 20 % of all adult sarcomas. However, the molecular pathogenesis of this malignancy is still poorly understood. Here, we showed that GPS2 expression was downregulated in LPS and correlated with the prognosis of this disease. In vitro study showed that knockdown of GPS2 resulted in enhanced proliferation and migration of LPS cell line SW872, without significant influence of cell death. Conclusively, our results suggest that GPS2 may act as a tumor suppressor in LPS and serve as a potential prognosis marker for this disease.


Assuntos
Peptídeos e Proteínas de Sinalização Intracelular/metabolismo , Lipossarcoma/metabolismo , Proteínas Supressoras de Tumor/metabolismo , Adipogenia , Adulto , Idoso , Idoso de 80 Anos ou mais , Apoptose/genética , Biomarcadores , Ciclo Celular/genética , Linhagem Celular Tumoral , Movimento Celular/genética , Proliferação de Células , Feminino , Seguimentos , Expressão Gênica , Técnicas de Silenciamento de Genes , Humanos , Imuno-Histoquímica , Peptídeos e Proteínas de Sinalização Intracelular/genética , Lipossarcoma/genética , Lipossarcoma/mortalidade , Lipossarcoma/patologia , Masculino , Pessoa de Meia-Idade , Prognóstico , Transdução de Sinais , Proteínas Supressoras de Tumor/genética
9.
Asian Pac J Cancer Prev ; 17(3): 1427-31, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27039784

RESUMO

BACKGROUND: Potential disadvantages of blood transfusion during curative gastrectomy for gastric cancer have been reported, and the role of peri-operative transfusions remains to be ascertained. Thus, the aim of our study was to survey its impact in patients with gastric cancer undergoinging gastrectomy. MATERIALS AND METHODS: Clinical data of patients receiving curative gastrectomy at Far Eastern Memorial Hospital were obtained. Findings for pre-operative anemia states, pre-, peri- and post-operative transfusion of red blood cell (RBC) products as well as post-operative complication events were collected for univariate analysis. RESULTS: A total of 116 patients with gastric cancer received gastrectomy at Far Eastern Memorial Hospital from 2011 to 2014. Both pre-operative and intra- and post-operative transfusion of RBC products were markedly associated with post-operative infectious events (OR: 3.70, 95% CI: 1.43-9.58, P=0.002; OR: 8.20, 95% CI: 3.11-22.62, P<0.001, respectively). In addition, peri- and post-operative RBC transfusion was significantly associated with prolonged hospital stay from admission to discharge (OR: 8.66, 95% CI: 1.73-83.00, P=0.002) and post-operative acute renal failure (OR: 19.69, 95% CI: 2.66-854.56, P<0.001). Also, the overall survival was seemingly decreased by peri-operative RBC transfusion in our gastric cancer cases (P=0.078). CONCLUSIONS: Our survey indicated that peri-operative RBC transfusion could increase the risk of infectious events and acute renal failure post curative gastrectomy as well as worsen the overall survival in gastric cancer cases. Hence, unnecessary blood transfusion before, during and after curative gastrectomy should be avoided in patients with gastric cancer.


Assuntos
Adenocarcinoma/cirurgia , Anemia/etiologia , Gastrectomia/efeitos adversos , Neoplasias Gastrointestinais/cirurgia , Tumores do Estroma Gastrointestinal/cirurgia , Complicações Pós-Operatórias , Neoplasias Gástricas/cirurgia , Reação Transfusional , Adenocarcinoma/complicações , Adenocarcinoma/patologia , Idoso , Anemia/patologia , Feminino , Seguimentos , Neoplasias Gastrointestinais/complicações , Neoplasias Gastrointestinais/patologia , Tumores do Estroma Gastrointestinal/complicações , Tumores do Estroma Gastrointestinal/patologia , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Neoplasias Gástricas/complicações , Neoplasias Gástricas/patologia , Taxa de Sobrevida
10.
Materials (Basel) ; 9(6)2016 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-28773553

RESUMO

The photocatalytic activity of an amorphous titanium oxide (a-TiOx) film was modified using a two-step deposition. The fluorinated base layer with a nano-textured surface prepared by a selective fluorination etching process acted as growth seeds in the subsequent a-TiOx deposition. A nanorod-like microstructure was achievable from the resulting a-TiOx film due to the self-assembled deposition. Compared to the a-TiOx film directly deposited onto the untreated base layer, the rate constant of this fluorinate-free a-TiOx film surface for decomposing methylene blue (MB) solution that was employed to assess the film's photocatalytic activity was markedly increased from 0.0076 min-1 to 0.0267 min-1 as a mechanism for the marked increase in the specific surface area.

11.
Materials (Basel) ; 8(7): 4273-4286, 2015 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-28793439

RESUMO

This study achieved a nanocomposite structure of nickel oxide (NiO)/titanium dioxide (TiO2) heterojunction on a TiO2 film surface. The photocatalytic activity of this structure evaluated by decomposing methylene blue (MB) solution was strongly correlated to the conductive behavior of the NiO film. A p-type NiO film of high concentration in contact with the native n-type TiO2 film, which resulted in a strong inner electrical field to effectively separate the photogenerated electron-hole pairs, exhibited a much better photocatalytic activity than the controlled TiO2 film. In addition, the photocatalytic activity of the NiO/TiO2 nanocomposite structure was enhanced as the thickness of the p-NiO film decreased, which was beneficial for the migration of the photogenerated carriers to the structural surface.

12.
Zhonghua Wai Ke Za Zhi ; 51(10): 891-4, 2013 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-24433766

RESUMO

OBJECTIVE: To evaluate prognostic factors predicting postoperative period for patients with primary retroperitoneal leiomyosarcoma. METHODS: The clinical data and prognosis of 35 patients with primary retroperitoneal leiomyosarcoma between August 2002 and June 2011 were retrospectively reviewed and analyzed. RESULTS: The resectability rate of primary tumors was 91.4% (32/35) , and 71.4% (25/35) of the patients underwent complete resection. The 21 patients (84.0%) who got a complete resection of the primary tumor got tumor recurrence and died of tumor recurrence eventually. The overall 1-, 3-, 5-year survival rate were 82.9%, 54.3% and 31.4% and the median survival was 36 months. In the analysis of factors influencing postoperative survival, factors associated with postoperative survive were modus operandi of the tumor resection (χ(2) = 16.871, P = 0.000), tumor size (χ(2) = 5.548, P = 0.019) and tumor grade (χ(2) = 8.080, P = 0.014); the difference between age (χ(2) = 0.073, P = 0.787), gender (χ(2) = 2.181, P = 0.140) and adjuvant therapy (χ(2) = 1.344, P = 0.511) got no statistical significance. CONCLUSIONS: The efficiency of adjuvant therapy for primary retroperitoneal leiomyosarcoma is not clear, complete resection remains the mainstream for primary leiomyosarcoma. Incomplete resection, large tumor (tumor diameter ≥ 10 cm) and high grade tumor predict shorter postoperative survival period.


Assuntos
Leiomiossarcoma/mortalidade , Neoplasias Retroperitoneais/mortalidade , Adulto , Idoso , Feminino , Seguimentos , Humanos , Leiomiossarcoma/cirurgia , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Neoplasias Retroperitoneais/cirurgia , Estudos Retrospectivos , Taxa de Sobrevida
13.
Clin Chim Acta ; 411(5-6): 336-44, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-19945452

RESUMO

BACKGROUND: Low-density lipoprotein (LDL) is a natural metabolite of very-low-density lipoprotein (VLDL) in the circulation. Systematic investigation of total protein components and dynamics might provide insights into this normal metabolic process. METHODS: VLDL and LDL were purified from normolipidemia pooled plasma by gradient ultracentrifugation with either ionic or non-ionic media. The protein contents were compared by liquid chromatography tandem mass analyses based on isobaric tag for relative and absolute quantitation and two-dimensional gel electrophoresis. RESULTS: Our comparative lipoproteomes revealed 21 associated proteins. Combined with Western blot analysis, and on the basis of the differential expression levels we classified them into 3 groups: (i) VLDL>LDL [apolipoprotein (apo) A-IV, apo(a), apoCs, apoE, apoJ and serum amyloid A-4]; (ii) VLDL

Assuntos
Lipoproteínas HDL/sangue , Lipoproteínas LDL/sangue , Proteômica , Adulto , Western Blotting , Centrifugação com Gradiente de Concentração , Cromatografia Líquida , Eletroforese em Gel Bidimensional , Feminino , Humanos , Lipoproteínas HDL/química , Lipoproteínas HDL/metabolismo , Lipoproteínas LDL/química , Lipoproteínas LDL/metabolismo , Masculino , Valores de Referência , Espectrometria de Massas em Tandem
14.
Nan Fang Yi Ke Da Xue Xue Bao ; 29(5): 922-4, 928, 2009 May.
Artigo em Chinês | MEDLINE | ID: mdl-19460709

RESUMO

OBJECTIVE: To assess the feasibility and safety of excising or patching the inferior vena cava (IVC) without replacement in patients with primary retroperitoneal tumors (PRPT) involving the IVC. METHODS: A retrospective analysis was conducted in 116 consecutive patients with PRPT presented to our Hospital between December 2007 and December 2008. IVC involvement was found in 11.2% of the cases, and in 93 cases receiving surgical tumor removal, the complete resection rate was 93.55%. According to the location of IVC involvement by the PRPT, the cases were classified into 3 groups with IVC involvement in the segment from the second hepatic portal vein to the renal vein (segment A), the segment on the bilateral renal vein plane (segment B), and the segment from the caval bifurcation to the renal vein (segment C). RESULTS: The most common vascular involvement occurred in segment C (61.54%, 8/13), and 2 cases presented with segment A involvement and 2 had segment B involvement. All the 3 segments of IVC were involved in 1 case. Five cases with IVC involvement received IVC patching only, and 4 had resection or ligation of the segment C of the IVC, and resection of the segment A and B of the IVC was performed in 2 and 1 case, respectively. One patient received complete resection of whole IVC involved. All patients recovered smoothly and were discharged. CONCLUSION: The infrarenal IVC can be ligated or resected safely without reconstruction. Combined resection of the bilateral renal vein and segment B of the IVC may result in renal insufficiency. IVC involvement and occlusion between the second hepatic portal and renal veins can be ligated safely without affecting the renal function.


Assuntos
Neoplasias Retroperitoneais/patologia , Neoplasias Retroperitoneais/cirurgia , Procedimentos Cirúrgicos Vasculares/métodos , Veia Cava Inferior/cirurgia , Adulto , Estudos de Viabilidade , Feminino , Humanos , Ligadura , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Estudos Retrospectivos , Veia Cava Inferior/patologia , Adulto Jovem
15.
Chang Gung Med J ; 27(10): 777-81, 2004 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-15646302

RESUMO

Squamous cell carcinoma is a kind of epithelial tumor and the most common malignant tumor of the oral cavity. Clinically, it may be misdiagnosed because of its variable appearances. Carcinomas of the gingiva especially tend to present as having benign features, and this leads to delays in diagnoses or even to misdiagnoses. We had a patient with squamous cell carcinoma (SCC) of the gingiva, and our initial impression was hyperplastic inflammatory tissue. This case demonstrates the importance of being highly suspicious of oral lesions which undergo malignant change, especially when they do not promptly respond to conventional therapy.


Assuntos
Carcinoma de Células Escamosas/diagnóstico , Neoplasias Gengivais/diagnóstico , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/terapia , Neoplasias Gengivais/patologia , Neoplasias Gengivais/terapia , Humanos , Masculino , Mandíbula , Pessoa de Meia-Idade
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA