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1.
J Org Chem ; 84(19): 12301-12313, 2019 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-31482711

RESUMO

A copper-catalyzed protocol for the construction of various 2-aryl(alkyl)-3-acylquinolines or 3-arylquinolines using readily available anthranils and 1,3-diketones or aldehydes as starting materials is reported herein. Dioxygen as the sole oxidant and hexafluoroisopropanol as the solvent play an important role in both procedures. This ring-opening/reconstruction strategy involving N-O bond cleavage and C-N/C-C bond formation features high yields and broad substrate scope.

2.
Org Biomol Chem ; 17(24): 5902-5907, 2019 06 18.
Artigo em Inglês | MEDLINE | ID: mdl-31140526

RESUMO

Copper-catalyzed coupling of α-keto acids with anthranils is reported for the synthesis of α-ketoamides. This process involves N-O/C-O bond cleavages and C-N bond formation. Furthermore, the decarboxylation of α-keto acids can be successfully suppressed under redox-neutral conditions.

3.
J Org Chem ; 82(23): 12892-12898, 2017 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-29110477

RESUMO

A transition-metal-free protocol for the construction of C-S bonds has been developed. Acetylacetone acts as a new and green aryl source for the synthesis of polysubstituted diarylsulfides bearing a free hydroxy group and a ketone group, which provides a new access to a series of flavonoids containing a thioaryl group. In addition, a series of α-thioarylcarbonyl compounds are obtained in good to excellent yields.

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