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1.
Eur Rev Med Pharmacol Sci ; 25(2): 1050-1059, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33577061

RESUMO

OBJECTIVE: This study aimed to investigate the clinical and pathological features of leprosy bacillus-related neuropathy in different clinical stages. PATIENTS AND METHODS: Four patients confirmed to have leprosy between 2012 and 2020 were chosen as the primary study subjects. The patients' clinical data were retrospectively analyzed to investigate the clinical and pathological features of the different clinical types of leprosy. RESULTS: Each patient had a different degree of deformity. For instance, in Case 1, upon dermatological examination, the eyebrows were not falling off, and the face was slightly invaded. The great auricular nerve was thickened, and there were plaques on the back of the right hand with ill-defined edges but no itching. No atrophy in the thenar or hypothenar was observed, though pain and a warm sensation were noted. The swelling of the right leg was accompanied by sensory abnormalities. Moreover, the bilateral ulnar nerves were swollen, and demyelination changes were observed upon nerve biopsy. A small number of granulomas were noted in the nerve interstitium, and the acid-fast staining was positive. Additionally, in Case 2, on dermatological examination, scars were observed on the front of the tibia, and large, reddish, symmetrically distributed patches were seen on the back. Satellite foci were visible as well. Contracture was observed in the little finger, and the ulnar nerve was damaged. Skin and nerve biopsy revealed leprosy bacillus via acid-fast staining. CONCLUSIONS: Early detection and treatment are important methods of preventing and reducing damage to peripheral nerve function in patients with leprosy.

2.
PLoS One ; 16(2): e0246439, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33606752

RESUMO

The plastic hinge is a key factor in the ductile and plastic design of structures and an important basis for the seismic strengthening of structures. The formation and behavior of plastic hinges is critical for the seismic performance of an entire structure. The relocation of plastic hinges away from the beam end is an effective way of addressing brittle failure. In this paper, the cause of the shear buckling failure of prefabricated steel beams with corrugated webs and the strain variation at the flanges of steel beams are theoretically analyzed through structural tests. Based on the analysis results, a local strengthening method is proposed, and the effects of the beam sizes and the strengthening steel plate on the plastic hinges are obtained. In addition, a calculation method for determining the size of the strengthening steel plate that promotes the relocation of the plastic zone away from the beam end is given, a design method for plastic hinge relocation is proposed based on the test data, and its validity is verified.

3.
Scand J Rheumatol ; : 1-10, 2021 Feb 08.
Artigo em Inglês | MEDLINE | ID: mdl-33554691

RESUMO

Objective: Little is known about muscle wasting in elderly patients with rheumatoid arthritis (RA). We examined muscle characteristics and their clinical significance in this group. Method: Consecutive RA patients were recruited and clinical data were collected. Muscle mass and distribution were assessed using bioelectric impedance analysis. Myopenia was defined as an appendicular skeletal muscle mass index (ASMI) ≤ 7.0 kg/m2 (men) and ≤ 5.7 kg/m2 (women). Results: Among the 643 RA patients recruited, 165 (25.7%) were elderly patients (age ≥ 60 years) with a mean age of 65.1 ± 4.5 years. Compared with young patients (age < 60 years), elderly RA patients had significantly higher Disease Activity Score based on 28-joint count-C-reactive protein (DAS28-CRP) (median 3.4 vs 3.2), Health Assessment Questionnaire Disability Index (HAQ-DI) (0.38 vs 0.13), and modified total Sharp score (mTSS) (16 vs 9), and a higher proportion of myopenia (54.5% vs 41.4%; all p < 0.01). Elderly RA patients with myopenia (n = 90, 14.0%) had significantly higher DAS28-CRP (3.6 vs 3.0), HAQ-DI (0.50 vs 0.12), and mTSS (21 vs 7) than young RA patients without myopenia (n = 280, 43.5%; all p < 0.0083). Multivariate logistic and linear regression analyses showed that myopenia, high HAQ-DI, active smoking, hypertension, diabetes, and coronary atherosclerotic heart disease were the main relevant characteristics of elderly RA patients. Age positively correlated with HAQ-DI, and ASMI negatively correlated with HAQ-DI (both p < 0.01). Further mediation analysis showed that ASMI partially mediated the association between age and HAQ-DI. Conclusion: Our data reveal that half of elderly RA patients manifest myopenia which aggravates physical dysfunction as a mediator of age. Myopenia, a neglected complication in elderly RA patients, should be recognized and further investigated.

4.
Clin Lab ; 67(2)2021 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-33616322

RESUMO

BACKGROUND: Pulmonary hamartomas are the most common benign tumors of the lungs and can occur anywhere in the lungs, normal hyperplasia, congenital malformation, inflammatory changes, and tumorigenesis are hypothesized to underlie the pathogeny, but the definite etiology remains to be elucidated. Primary pulmonary lymphoma (PPL) refers to clonal lymphoid hyperplasia of one or both lungs in patients who have no detectable extrapulmonary lymphoma or bone marrow involvement at the time of diagnosis and during the subsequent 3 months. It is rare for both diseases to occur in the lungs of the same patient. METHODS: Appropriate laboratory tests, Chest CT scan, bronchoscopy and CT-guided percutaneous lung biopsy. RESULTS: Laboratory tests showed (1-3)-ß-D-glucan was 226.3 pg/mL and sputum culture of Aspergillus niger. Chest Computer Tomography (CT) scan showed multiple flaky high-density shadows in both lungs, proven to be right hamartoma with left lung pulmonary primary lymphoma by bronchoscopy biopsy and CT guided percutaneous needle lung biopsy. CONCLUSIONS: When there are high density shadows or nodules in different parts of one patient's lung, these lesions may not be the same disease. Therefore, it is necessary to conduct biopsies of the lesions in different parts of the lung.

5.
Nan Fang Yi Ke Da Xue Xue Bao ; 41(2): 243-249, 2021 Feb 25.
Artigo em Chinês | MEDLINE | ID: mdl-33624598

RESUMO

OBJECTIVE: To propose a motion compensation reconstruction method based on robust principal component analysis (RPCA) to reduce the influence of streak artifacts on accurate estimation of interphase motion deformation fields. OBJECTIVE: We propose a RPCA motion compensation reconstruction algorithm to improve the estimation of motion deformation fields based on the traditional MC-FDK algorithm. RPCA was used to decompose the cone-beam computed tomography (CBCT) images into low-rank and sparse components, and the motion deformation fields between different phase images were then estimated using Horn and Schunck optical flow method from the low-rank images to reduce the influence of striping artifacts on the accuracy of estimation of interphase motion deformation fields. The performance of the algorithm was evaluated using simulation data and real data. The simulation phantom data was obtained by back-projection of 4D-CT images acquired from Philips 16-slice spiral CT using MATLAB software programming according to the scanning geometry of Varian Edge accelerator. The real patient data were obtained using the Elekta Synergy system of CBCT scanning system with half-fan mode CB projection data from lung cancer patients. OBJECTIVE: Compared with images reconstructed using the traditional MC-FDK algorithm, the reconstructed image using the proposed method had clearer tissue boundaries with reduced motion artifact was reduced. The results of phantom data reconstruction showed that compared with the MC- FDK algorithm, the proposed algorithms resulted in improvements of PSNR by 25.4% and SSIM by 7.6%; compared with the FDK algorithm, PSNR was improved by 37.9% and SSIM by 17.6%. OBJECTIVE: The proposed algorithm can achieve accurate estimation of inter-phase motion deformation fields and improve the quality of the reconstructed CBCT images.


Assuntos
Artefatos , Tomografia Computadorizada Quadridimensional , Tomografia Computadorizada de Feixe Cônico , Humanos , Movimento (Física) , Análise de Componente Principal
6.
Int J Behav Med ; 2021 Feb 24.
Artigo em Inglês | MEDLINE | ID: mdl-33629219

RESUMO

BACKGROUND: Cancer survivors are prone to insomnia due to the physical and psychological sequelae of cancer and treatment. Individuals with insomnia may present symptoms of hyperarousal. Cancer survivors with insomnia and trait hyperarousal may require different clinical treatments than patients with insomnia without trait hyperarousal. To our knowledge, no study has examined these factors previously. This study examined the relation between insomnia and trait hyperarousal in cancer survivors. METHODS: The sample included 160 individuals with previous cancer diagnoses who met DSM-5 criteria for insomnia disorder. Measures were collected with cross-sectional batteries of questionnaires, including the Insomnia Severity Index (ISI) and Hyperarousal Scale (HAS). This study is based on baseline data collected in a randomized clinical trial comparing CBT-I to acupuncture for cancer survivors with insomnia (Garland, Gehrman, Barg, Xie, & Mao, 2016). RESULTS: Hyperarousal was positively associated with insomnia (ISI total score) in bivariate correlations (r = .350, p < .01) and linear regressions (F = 22.06, p < .001). In bivariate correlations, hyperarousal was related to perceptions about the consequences of disturbed sleep rather than reported sleep patterns. For example, hyperarousal was positively related to reported satisfaction (r = .159, p < .05) and worry about sleep (r = .415, p < .01), but not to falling asleep, staying asleep, or awakening too early. In regressions, younger age, insomnia duration, and worry about sleep were uniquely associated with hyperarousal when adjusting for insomnia (B = 0.200, B = 0.177, B = -0.182, p < .05). CONCLUSIONS: Hyperarousal is associated with psychological appraisal of insomnia rather than reported sleep pattern. Younger age and longer duration of insomnia are associated with trait hyperarousal. These findings suggest targeting trait hyperarousal with amplified psychological treatment may lead to more personalized, effective treatment for insomnia.

7.
Int Endod J ; 2021 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-33539038

RESUMO

AIM: To explore the role of DNA methylation in the innate immunity of dental pulp, this study investigated the effect of 5-aza-2'-deoxycytidine (AZA) on lipoteichoic acid (LTA)-induced cytokine production and related intracellular signaling pathways in human odontoblast-like cells (hOBs). METHODOLOGY: hOBs were cultured and differentiated from human dental pulp tissue and the odontoblastic phenotype of the cells were detected using immunofluorescence, qRT-PCR and western blotting. hOBs were pretreated with AZA and then stimulated with 10 µg/mL LTA. The levels of 42 cytokines related to immunity and inflammation were examined using a cytokine antibody array and verified using qRT-PCR and ELISA. The effect of AZA on the LTA-induced NF-κB and MAPK signaling pathways was explored using western blotting. The cells were treated with the specific NF-κB inhibitor PDTC and MAPK inhibitors (the ERK inhibitor U0126, the p38 inhibitor SB203580, and the JNK inhibitor SP600125) to further confirm the role of the signaling pathways in LTA-treated hOBs. DNA immunoprecipitation-PCR was used to examine the dynamic methylation status of the gene promoters of myeloid differentiation primary response 88 (MyD88) and tumor necrosis factor receptor associated factor 6 (TRAF6) in the LTA-induced hOBs. Statistical analyses of the differences between two groups were performed using Student's t-test. One-way analysis of variance (ANOVA) or repeated-measures ANOVA with a post hoc Dunnett's test were used to assess the differences between multiple sets of data. P<0.05 was considered to be statistically significant. RESULTS: The odontoblastic markers were significantly higher in hOBs than those in human dental pulp cells (hDPCs) (P<0.05). According to the cytokine antibody array results, hOBs pretreated with AZA had significantly increased production of several inflammatory cytokines (P<0.05), in which the expression levels of IL-6 and IL-8 were the most dramatically increased upon LTA stimulation (P<0.01). Furthermore, AZA resulted in the significant upregulation of p-IKKα/ß, p-IκBα, p-p65, p-p38 and p-ERK in LTA-stimulated hOBs (P<0.01). Treatment with the NF-κB pathway inhibitor suppressed both IL-6 and IL-8 expression (P<0.05), whereas inhibitors of the MAPK pathway (SB203580 and SP600125) did not. In LTA-treated hOBs, AZA significantly increased the expression levels of TRAF6 and MyD88 (P<0.05). AZA induced MyD88 promoter hypomethylation but did not affect TRAF6 methylation. CONCLUSION: AZA regulated the LTA-induced inflammatory response through NF-κB signal pathway in hOBs. This study highlights the important role of DNA methylation in the immunity defense of odontoblasts during the dental pulp immunity response to caries.

8.
Phys Rev Lett ; 126(1): 016401, 2021 Jan 08.
Artigo em Inglês | MEDLINE | ID: mdl-33480797

RESUMO

We use first-principles methods to demonstrate that, in ZrTe_{5}, a layered van der Waals material like graphite, atomic displacements corresponding to five of the six zone-center A_{g} (symmetry-preserving) phonon modes can drive a topological transition from a strong to a weak topological insulator with a Dirac semimetal state emerging at the transition, giving rise to a Dirac topology surface in the multidimensional space formed by the A_{g} phonon modes. This implies that the topological transition in ZrTe_{5} can be realized with many different settings of external stimuli capable of penetrating through the phonon-space Dirac surface without breaking the crystallographic symmetry. Furthermore, we predict that domains with effective mass of opposite signs can be created by laser pumping and will host Weyl modes of opposite chirality propagating along the domain boundaries. Studying phonon-space topology surfaces provides a new route to understanding and utilizing the exotic physical properties of ZrTe_{5} and related quantum materials.

9.
Zhonghua Xin Xue Guan Bing Za Zhi ; 49(1): 31-36, 2021 Jan 11.
Artigo em Chinês | MEDLINE | ID: mdl-33429483

RESUMO

Objective: To investigate the related factors of myocardial fibrosis in patients with hypertrophic cardiomyopathy. Methods: Patients with hypertrophic cardiomyopathy, hospitalized in the First People's Hospital of Yunnan Province from January 2016 to May 2020, were included in this cross-sectional study. Patients were divided into delayed enhancement positive group (fibrosis group) and non-delayed enhancement group (non-fibrosis group). According to the maximum left ventricular end diastolic wall thickness (LVMWT), patients in the fibrosis group was further divided into mild hypertrophy group, moderate hypertrophy group and severe hypertrophy group. The baseline clinical data of patients were collected by medical record management system. All enrolled patients underwent cardiac magnetic resonance imaging (CMR). The presence and location of myocardial fibrosis were identified by CMR gadolinium contrast delayed enhancement (LGE). The range of LGE (LGE%) was calculated by visual analysis. The levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI) in peripheral blood were measured. Results: A total of 48 patients ( age (46.4±14.3) years, 42 (87.5%) males) were enrolled. There were 34 LGE positive cases (fibrosis group) and 14 LGE negative cases (non-fibrosis group). Compared with non-fibrosis group, patients in fibrosis group were younger (P=0.038) and prevalence of NYHA grade Ⅲ/Ⅳ was higher (P=0.00). Compared with non-fibrosis group, patients in fibrosis group had thicker LVMWT (P= 0.008), higher left ventricular mass index(LVMI) (P=0.001), higher left ventricular end diastolic volume (LVEDV) (P=0.043), lower left ventricular ejection fraction (LVEF) and cardiac index (CI) (all P <0.05). The levels of NT-proBNP and cTnI were significantly higher in fibrosis group than in non-fibrosis group (2 760.5 (1 503.4, 3 783.6) ng / L vs. 861.3 (552.2, 1 092.8) ng / L, P=0.002; 0.970 (0.448, 1.684)µg / L vs. 0.147 (0.033, 0.251)µg / L, P=0.041).In fibrosis group, there were 15 cases of mild hypertrophy (mild hypertrophy group), 10 cases of moderate hypertrophy (moderate hypertrophy group), and 9 cases of severe hypertrophy (severe hypertrophy group). The LGE% and NT-proBNP and cTnI increased in proportion with increasing myocardial hypertrophy (P<0.05). LGE% was negatively correlated with age (r=-0.618, P=0.011), and positively correlated with NT-proBNP and cTnI levels (r=0.271, P=0.010; r=0.111,P=0.013, respectively), and positively correlated with LVEDV, LVMWT and LVMI (r=0.438, P=0.09; r=0.735, P=0.001; r=0.532, P=0.034, respectively). Conclusions: In patients with hypertrophic cardiomyopathy, the extent of myocardial fibrosis increases with the increase of myocardial hypertrophy. Myocardial fibrosis is negatively correlated with age, and positively correlated with NT-proBNP and cTnI, as well as LVEDV, LVMWT and LVMI in this patient cohort.

10.
Zhonghua Yi Xue Za Zhi ; 101(1): 57-61, 2021 Jan 05.
Artigo em Chinês | MEDLINE | ID: mdl-33423446

RESUMO

Objective: To investigate the clinicopathological and ultrasonic characteristics of patients with breast encapsulated papillary carcinoma (EPC) and the comparative analysis of different subtypes. Methods: A total of 57 patients with pathological diagnosis of breast EPC in the First Affiliated Hospital of Nanjing Medical University from September 2014 to August 2020 were retrospectively collected. Based on pathological diagnosis, patients were divided into 3 subtypes, and their clinical, pathological and ultrasonic manifestations were compared and analyzed. Results: Among the enrolled patients, there were 2 males and 55 females, aged 41-88 (63±11) years. The lesion diameter of EPC was 7.0-7.5 (2.9±1.9) cm. There were 16 cases of simple EPC, 9 cases of EPC with ductal carcinoma in situ (DCIS), and 32 cases of EPC with infiltration. The molecular classification was mainly luminal (55/57, 96.6%), of which 38 cases were Luminal A type and 17 cases were Luminal B type. The majority ultrasound images of EPC showed nodules with size greater than 2 cm (68.4%), regular morphology (64.9%), edge finishing (54.4%), no burr forming angles (82.5%), and no calcification (93%). There were differences between different subtypes. The simple EPC was closer to the nipple than the EPC with infiltration, with regular shape and smooth edge (P<0.05). Compared with the EPC with DCIS, the EPC with infiltration had richer blood flow and was farther away from the nipple (P<0.05). There was no significant difference between the simple EPC and the EPC with DCIS (P>0.05). Conclusion: The simple EPC often showed benign signs on ultrasound, such as regular morphology, smooth edge, and cystic-solid internal structure. If the distance between the lesion and the nipple was greater than 3 cm, the shape was irregular, and the edge was blurred, the possibility of EPC with infiltration was high. Multi-modality image fusion was helpful for accurate diagnosis and treatment of EPC.


Assuntos
Neoplasias da Mama , Carcinoma Intraductal não Infiltrante , Carcinoma Papilar , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias da Mama/diagnóstico por imagem , Carcinoma Intraductal não Infiltrante/diagnóstico por imagem , Carcinoma Papilar/diagnóstico por imagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Ultrassom
11.
Public Health ; 191: 33-38, 2021 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-33482625

RESUMO

OBJECTIVE: The aim of the study was to estimate the gout burden and risk factors in China from 1990 to 2017. STUDY DESIGN: The Global Burden of Disease (GBD) Study uses various analytical tools and a diverse set of data sources to generate comparable estimates of deaths and mortality rates broken down by age, sex, cause, year, and geography. METHODS: We used the results from the GBD Study 2017 to compare disability-adjusted life years (DALYs), prevalence, incidence, and risk factors of gout in China. The median of the percentage change and 95% uncertainty intervals were determined for the period between 1990 and 2017. RESULTS: The age-standardized DALY rate, prevalence, and incidence increased 6.92%, 6.88%, and 6.16%, respectively, in China from 1990 to 2017. Although the rates of gout both globally and in China were increasing, the range of change for males in China was larger than that of the global level. All risk factors combined accounted for 30.04% of gout DALYs in 2017. The leading risk factors for gout DALYs were high body mass index and impaired kidney function, and the proportion of high body mass index increased significantly from 10.67% to 24.31%, whereas the proportion of impaired kidney function remained basically unchanged. CONCLUSIONS: The age-standardized DALY rate, prevalence, and incidence in China have increased progressively since 1990. Increasing attention on body weight management should be prioritized for controlling the rising prevalence of gout in the young and middle-aged population.

12.
Zhonghua Zhong Liu Za Zhi ; 43(1): 132-136, 2021 Jan 23.
Artigo em Chinês | MEDLINE | ID: mdl-33472326

RESUMO

Objective: To explore the clinicopathological characteristics and prognosis of patients with ovarian metastases from colorectal cancer. Methods: A total of 122 female patients with ovarian metastases from colorectal cancer underwent treatment in Cancer Hospital, Chinese Academy of Medical Sciences between 2010 and 2015 were recruited. The clinicopathological features, treatment details and survival data of these patients were retrospectively analyzed. Kaplan-Maier method was used for survival analysis, log rank test and Cox proportional hazards model were used for prognostic factor analysis. Results: The median overall survival (OS) was 19.7 months. The 1-year, 3-years and 5-years OS rates were 72.1%, 24.7% and 9.9%, respectively. A total of 99 (81.1%) patients underwent oophorectomy. The median OS of patients who underwent oophorectomy was 21.9 months, significantly longer than 10.3 months of patients without oophorectomy (P<0.01). Ovary as the only site of metastasis, primary tumor resection, and oophorectomy were associated with improved survival (all P<0.01). Primary tumor resection and oophorectomy were independent prognostic factors for OS (both P<0.01). Conclusion: Patients with ovarian metastases from colorectal cancer might acquire a survival benefit from surgical resection of the primary tumor and ovaries.


Assuntos
Neoplasias Colorretais , Neoplasias Ovarianas , Neoplasias Colorretais/cirurgia , Feminino , Humanos , Neoplasias Ovarianas/cirurgia , Prognóstico , Estudos Retrospectivos
14.
Zhonghua Wei Chang Wai Ke Za Zhi ; 24(1): 43-47, 2021 Jan 25.
Artigo em Chinês | MEDLINE | ID: mdl-33461251

RESUMO

Haining City and Jiashan County in Zhejiang Province are the first areas to carry out colorectal cancer screening in China, which started in the early 1970s and has been going on for more than 40 years. Meanwhile, Haining and Jiashan have also become the first batch of National Demonstration Bases for Early Diagnosis and Treatment of Colorectal Cancer. In the past 40 years, owing to Professor Zheng Shu who is brave and innovative, with an indomitable spirit, as well as the unremitting efforts and active exploration of all the team members, colorectal cancer screening which was unknown by the public and implemented with difficulties, has gradually been widely accepted and benefited the population. Today, remarkable achievements have been fulfilled in the colorectal cancer screening of Haining and Jiashan which has become the pioneer power in promoting the progress of colorectal cancer prevention and control in China and has certain influence both on China and the world. Meanwhile, a set of colorectal cancer screening strategies suitable for China has been explored and further promoted to be used nationwide, which is of great significance to the prevention and control of colorectal cancer in China. Looking forward to the future, the prevention and control of colorectal cancer in China is still difficult. We will continue to give full play to our existing advantages, not forget our original intention, move forward, explore innovation, and create greater glories!


Assuntos
Neoplasias do Colo , Neoplasias Colorretais , Detecção Precoce de Câncer/estatística & dados numéricos , China/epidemiologia , Neoplasias do Colo/diagnóstico , Neoplasias Colorretais/diagnóstico , Detecção Precoce de Câncer/métodos , História do Século XX , Humanos , Programas de Rastreamento/métodos , População Rural/estatística & dados numéricos
15.
Zhonghua Wei Chang Wai Ke Za Zhi ; 24(1): 94-100, 2021 Jan 25.
Artigo em Chinês | MEDLINE | ID: mdl-33461259

RESUMO

Intestinal failure (IF) is defined as the critical reduction of functional intestines below the minimum needed to absorb nutrients and fluids, so that intravenous supplementation with parenteral nutrition (PN) is required to maintain health and/or growth. Although the benefits are evident, patients receiving PN can suffer from serious cholestasis due to lack of enteral feeding and small intestinal bacterial overgrowth (SIBO). One such complication that may arise is intestinal failure-associated liver disease (IFALD). Evidences from recent studies suggest that alterations in the intestinal microbiota, as well as intraluminal bile acid driven signaling, may play a critical role in both hepatic and intestinal injury. Since Marshall first proposed the concept of the gut-liver axis in 1998, the role of gut-liver axis disorders in the development of IFALD has received considerable attention. The conversation between gut and liver is the key to maintain liver metabolism and intestinal homeostasis, which influences each other and is reciprocal causation. However, as a "forgotten organ" , intestinal microbiota on the pathogenesis of IFALD has not been well reflected. As such, we propose, for the first time, the concept of gut-microbiota-liver axis to emphasize the importance of intestinal microbiota in the interaction of gut-liver axis. Analysis and research on gut-microbiota-liver axis will be of great significance for understanding the pathogenesis of IFALD and improving the prevention and treatment measures.


Assuntos
Microbioma Gastrointestinal , Enteropatias , Hepatopatias , Fígado/fisiopatologia , Nutrição Parenteral/efeitos adversos , Síndrome do Intestino Curto/fisiopatologia , Infecções Bacterianas/etiologia , Infecções Bacterianas/fisiopatologia , Ácidos e Sais Biliares/fisiologia , Colestase/etiologia , Colestase/microbiologia , Colestase/fisiopatologia , Nutrição Enteral , Microbioma Gastrointestinal/fisiologia , Humanos , Enteropatias/etiologia , Enteropatias/microbiologia , Enteropatias/fisiopatologia , Intestinos/microbiologia , Intestinos/fisiologia , Intestinos/fisiopatologia , Fígado/microbiologia , Fígado/fisiologia , Hepatopatias/etiologia , Hepatopatias/microbiologia , Hepatopatias/fisiopatologia , Síndrome do Intestino Curto/complicações , Síndrome do Intestino Curto/dietoterapia , Transdução de Sinais
16.
Domest Anim Endocrinol ; 74: 106509, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32653739

RESUMO

MicroRNAs (miRNAs) are 21- to 24-nucleotide long small noncoding RNAs, which play an important role in follicular atresia and granulosa cell (GC) apoptosis in the mammalian ovary. Here, we report that miR-146b, a conserved and ovary-enriched miRNA, modulates estradiol (E2) secretion, GC apoptosis, and follicular atresia in pigs. Genome-wide analysis and quantitative real-time PCR revealed that miR-146b was significantly upregulated during follicular atresia, and fluorescence-activated cell sorting showed that miR-146b functioned as a proapoptotic factor to induce GC apoptosis. MicroRNA-mRNA network analysis and luciferase reporter assays showed that CYP19A1, the pivotal enzyme for E2 synthesis signaling, was directly targeted by miR-146b. Furthermore, miR-146b interacted with the 3'untranslated region of CYP19A1 to prevent translation, thereby regulating CYP19A1-mediated E2 secretion and GC apoptosis. However, miR-146b was not regulated by the transcription factor SMAD4 or oxidative stress, both of which are critical regulators of CYP19A1. We, thus, conclude that miR-146b is a novel epigenetic factor regulating GC functions, follicular development, and female reproduction.

17.
Support Care Cancer ; 29(1): 427-435, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32383073

RESUMO

PURPOSE: Approximately one in two cancer patients globally are under-treated for pain. Opioids and other analgesics represent the mainstay of cancer pain management; however, barriers to their use are well-documented. We evaluated whether acupuncture would be a preferable treatment option among cancer patients with attitudinal barriers to pharmacological pain management. METHODS: We conducted a cross-sectional survey of cancer patients at a tertiary urban cancer center and eleven suburban/rural hospitals in the Northeastern United States. We assessed attitudinal barriers to pharmacological pain management with the Barriers Questionnaire (BQ-13). The BQ-13 consists of two subscales: pain management beliefs and analgesic side effects. We also asked patients whether they prefer acupuncture, analgesics, or have no preference between these two modalities for pain management. Covariates included sociodemographics, clinical characteristics, and attitudes/beliefs about acupuncture. We used logistic regression to examine the association between attitudinal barriers and acupuncture preference. RESULTS: Among 628 patients, 197 (31.4%) preferred acupuncture for pain management, 146 (23.3%) preferred analgesics, and 285 (45.4%) had no preference. The highest reported attitudinal barriers were fear of addiction and fear of analgesic-associated constipation and nausea. Adjusting for covariates, we found that attitudinal barriers related to fear of analgesic side effects were significantly associated with acupuncture preference (adjusted odds ratio [AOR] 1.45, 95% confidence interval [CI] 1.17-1.81), but barriers related to pain management beliefs were not (AOR 1.17, 95% CI 0.91-1.51). Attitudes/beliefs about acupuncture (i.e., greater expected benefits, fewer perceived barriers, and more positive social norms) and female gender also predicted acupuncture preference, whereas race and educational status did not. CONCLUSION: Acupuncture may be a preferable treatment option among cancer patients at risk of inadequately controlled pain due to fear of analgesic side effects. Evidence-based integration of acupuncture and analgesics, guided by patient treatment preferences, represents an essential aspect of patient-centered care and has potential to address unmet cancer pain management needs.


Assuntos
Terapia por Acupuntura/métodos , Analgésicos/uso terapêutico , Neoplasias/complicações , Manejo da Dor/métodos , Dor/tratamento farmacológico , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/tratamento farmacológico , Estados Unidos
18.
Zhonghua Zhong Liu Za Zhi ; 42(11): 966-971, 2020 Nov 23.
Artigo em Chinês | MEDLINE | ID: mdl-33256310

RESUMO

Objective: To observe the short-term efficacy and safety of apatinib in combination with dose-dense paclitaxel and carboplatin in locally advanced triple-negative breast cancer (TNBC) patients. Methods: From September 2018 to September 2019, 17 stage Ⅱ/Ⅲ TNBC patients were enrolled in this single arm, single center prospective phase Ⅱ study. They received neoadjuvant treatment of apatinib 250 mg per day, paclitaxel 175 mg/m(2) on 1(st) day and a dose of carboplatin according to the area under curve (AUC)=4 on 2(nd) day, every 14 days as a cycle. Results: By January 2020, 16 cases completed 4-7 cycles of apatinib treatment and 4-8 cycles of chemotherapy. The median cycles of apatinib treatment and chemotherapy were 5 cycles and 6 cycles, respectively. Two cases achieved complete responses (CR), 12 achieved partial responses (PR), 2 achieved stable diseases (SD) and no progressive disease was observed. The objective response rate (ORR) was 87.5%, disease control rate (DCR) was 100%. By January 2020, among 12 patients who received surgery, 8 achieved pathologic complete response (pCR, 66.7%). The grade Ⅲ/Ⅳ adverse events included: neutropenia, thrombocytopenia in 3 cases (18.8%) each, anemia, fatigue, arrhythmia and alanine aminotransferase (ALT) elevation in 1 case each. Apatinib was interrupted in 5 cases, and was discontinued in 3 cases; chemotherapy dosage was reduced in 1 case. Conclusion: Apatinib in combination with dose-dense paclitaxel and carboplatin neoadjuvant therapy are effective and well tolerated in locally advanced TNBC patients.

19.
Zhonghua Er Ke Za Zhi ; 58(12): 1015-1017, 2020 Dec 02.
Artigo em Chinês | MEDLINE | ID: mdl-33256326
20.
Zhonghua Nei Ke Za Zhi ; 59(12): 960-967, 2020 Dec 01.
Artigo em Chinês | MEDLINE | ID: mdl-33256337

RESUMO

Objective: To compare the efficacy and safety of Changsulin® with Lantus® in treating patients with type 2 diabetes mellitus (T2DM). Methods: This was a phase Ⅲ, multicenter, randomized, open-label, parallel-group, active-controlled clinical trial. A total of 578 participants with T2DM inadequately controlled on oral hypoglycemic agents were randomized 3∶1 to Changsulin® or Lantus® treatment for 24 weeks. The efficacy measures included changes in glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), 2h postprandial plasma glucose (2hPG), 8-point self-monitoring of blood glucose (SMBG) profiles from baseline, and proportions of subjects achieving targets of HbA1c and FPG. The safety outcomes included rates of hypoglycemia, adverse events (AEs) and anti-insulin glargine antibody. Results: After 24 weeks of treatment, mean HbAlc decreased 1.16% and 1.25%, FPG decreased 3.05 mmol/L and 2.90 mmol/L, 2hPG decreased 2.49 mmol/L and 2.38 mmol/L in Changsulin® and in Lantus®, respectively. No significant differences could be viewed in above parameters between the two groups (all P>0.05). There were also no significant differences between Changsulin® and Lantus® in 8-point SMBG profiles from baseline and proportions of subjects achieving the targets of HbA1c and FPG (all P>0.05). The rates of total hypoglycemia (38.00% and 39.01% for Changsulin® and Lantus®, respectively) and nocturnal hypoglycemia (17.25% and 16.31% for Changsulin® and Lantus®, respectively) were similar between the two groups (all P>0.05). Most of the hypoglycemia events were asymptomatic, and no severe hypoglycemia were found in both groups. No differences were observed in rates of AEs (61.77% vs.52.48%) and anti-insulin glargine antibody (after 24 weeks of treatment, 6.91% vs.3.65%) between the two groups (all P>0.05). Conclusions: Changsulin® shows similar efficacy and safety profiles compared with Lantus® and Changsulin® treatment was well tolerated in patients with T2DM.

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