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1.
Zhen Ci Yan Jiu ; 44(12): 884-7, 2019 Dec 25.
Artigo em Chinês | MEDLINE | ID: mdl-31867907

RESUMO

OBJECTIVE: To investigate the immediate brain effect of auricular electroacupuncture (EA) in the treatment of primary insomnia (PI). METHODS: In this study, 15 subjects with PI who were diagnosed according to Pitsburgh Sleep Quality Index (PSQI), and other 15 age- and gender-matched subjects without insomnia were recruited in the present study. The PI patients received EA (4 Hz/20 Hz, a tolerable electrical current strength) of auricular concha for 30 min, and their resting state functional magnetic resonance imaging (fMRI) data before and after treatment were collected. The healthy subjects received no any treatment and their resting state fMRI data were collected. The diffe-rence of default mode network functional connectivity between the patients and healthy subjects, and changes of the patient's brain functional connectivity after EA treatment were estimated by using seed-point-based analysis (SPBA). RESULTS: Analysis by taking the posterior cingulate gyrus as the seed-point showed that compared with the healthy participants before treatment, the patient's brain functional connectivity between the posterior cingulate gyrus and the right insula, or the inferior frontal gyrus of the right opercularis region, or the right rolandic operculum was increased. After 30 minutes' EA treatment, the functional connectivity between the posterior cingulate gyrus and the precuneus, the left angular gyrus, the left frontal superior gyrus, the left frontal middle cortex, the right temporalis inferior gyrus, the right temporalis middle gyrus or the left medial orbitofrontal cortex was decreased, while the functional connectivity between the posterior cingulate gyrus and the right lingual gyrus, or the cortex surrounding the right calcarine fissure was increased. CONCLUSION: EA of auricular concha has an instant effect in modulating the brain default mode network in PI patients, which may be its brain mechanism underlying improvement of PI.


Assuntos
Eletroacupuntura , Distúrbios do Início e da Manutenção do Sono , Encéfalo , Mapeamento Encefálico , Humanos , Imagem por Ressonância Magnética , Distúrbios do Início e da Manutenção do Sono/terapia
2.
Zhen Ci Yan Jiu ; 44(11): 858-9, 2019 Nov 25.
Artigo em Chinês | MEDLINE | ID: mdl-31777239

RESUMO

In the present paper, we introduce a newly modified device named "transcutaneous electrical auricular concha stimulator (TEACS)" for rats. It concludes a main unit (power and control buttons) with newly designed specific output electrodes. Each of the output electrode is made up of two pieces of iron sheet containing magnet and can be firmly attached to the auricular concha and the corresponding site of dorsal auricle, respectively. The two iron sheets are separately connected to each of the output terminal of the main unit via two pieces of wire. This newly modified output electrode replaces the original wire clip, and solves the problems of easy loosening and easy injury of the original spring clip due to repeated usage, being simple, flexible and convenient in application.


Assuntos
Terapia por Estimulação Elétrica , Estimulação Elétrica Nervosa Transcutânea , Animais , Ratos
3.
Zhen Ci Yan Jiu ; 44(8): 554-9, 2019 Aug 25.
Artigo em Chinês | MEDLINE | ID: mdl-31475487

RESUMO

OBJECTIVE: To observe the effect of auricular electroacupuncture (EA) on intracellular Raf/ extracellular signal-regulated kinase (ERK)/ ribosomal S6 kinase (RSK)/ cAMP response element-binding protein (CREB) signal pathway in the hippocampus of depression model rats, so as to explore its anti-depressive mechanism. METHODS: A total of 60 male SD rats were randomly divided into control, model, auricular EA, PD98059(ERK inhibitor), DMSO (Dimethylsulfoxide), PD98059+EA groups (n=10 in each group). The rats in the control group were fed with normal diet without any treatment. The depression model was induced by chronic unpredictable mild stress (CUMS) for consecutive 21 days. EA (20 Hz, 2 mA) was applied to bilateral auricular "Xin"(Heart) and "Shenmen" for 30 min, once daily for 28 days. Rats of the PD98059, DMSO and PD98059+EA groups received intracerebroventricular injection of PD98059(100 µmol/L), DMSO and PD98059 (dissolved by DMSO) solutions (5 µL/d), respectively, once daily for 28 days. Sucrose preference test (sucrose consumption) was conducted at the baseline, before and after the intervention. The expression of hippocampal Raf, phosphorylated (p)-Raf, ERK, p-ERK, RSK, CREB and p-CREB proteins were detected by Western blot after EA intervention. RESULTS: Following modeling, the sucrose consumption volume, and the expression levels of hippocampal Raf, p-Raf, ERK, p-ERK, RSK, CREB, p-CREB proteins were significantly lower in the model group than those in the control group (P<0.01). Following the treatment, the sucrose consumption and the expression levels of Raf, p-Raf, ERK, p-ERK, RSK, CREB, p-CREB in the auricular EA group and those of p-Raf, ERK and CREB in the PD98059+EA group were obviously increased in comparison with the model group (P<0.05, P<0.01), the expression level of p-ERK in the PD98059 group was obviously decreased in comparison with the model group (P<0.05), suggesting an improvement of depression after auricular EA. Compared with auricular EA group, the expression level of p-ERK, p-CREB and RSK in the PD98059+EA group were significantly decreased (P<0.05). CONCLUSION: EA of auricular "Xin" and "Shenmen" is able to improve depression in depression rats, which is probably related to its effect in promoting activities of hippocampal Raf/ERK/RSK/CREB signaling.


Assuntos
Eletroacupuntura , Animais , Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico , Depressão , MAP Quinases Reguladas por Sinal Extracelular , Hipocampo , Masculino , Ratos , Ratos Sprague-Dawley , Proteínas Quinases S6 Ribossômicas , Transdução de Sinais
4.
Artigo em Inglês | MEDLINE | ID: mdl-26640498

RESUMO

Objective. To identify the optimum treatment protocol for insomnia among auricular, body, and abdominal needling methods. Methods. A three-factor (3 needling protocols) and three-level experimental scheme was designed based on orthogonal method. 54 patients of insomnia differentiated as internal harassment of phlegm-heat syndrome were given two courses of acupuncture treatment (each with 20 times of acupuncture). The therapeutic effects were evaluated by comparing the Pittsburgh sleep quality index (PSQI), Hamilton Depression Scale (HAMD) scores, and Hamilton Anxiety Scale (HAMA) scores of patients before treatment, after one course of treatment, and after two courses of treatment as well as one month after treatment. Results. Body, auricular, and abdominal acupuncture treatments all alleviated symptoms of insomnia, depression, and anxiety, but body and auricular acupuncture had stronger therapeutic effects. Conclusions. Body acupuncture at basic points shall be given priority in protocol selection for insomnia. The second-best choice is auricular acupuncture with basic points combined with points based on Traditional Chinese Medicine (TCM) theories. Abdominal needling with very quick effect can be an alternative protocol with basic points combined with syndrome differentiation points.

5.
Chin J Integr Med ; 21(12): 887-94, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26631173

RESUMO

Treatment by auricular acupuncture has a long history. Ear-acupoint research has been advancing step by step in China and also in Europe. Auricles are rich in nerves, therefore a close relationship with different functions of the human body has been proved by the research teams of the two main authors of this article from China and Austria. In recent years, great progress has been made in the research of regulating human body functions through electroacupuncture at the auricular branch of the vagus nerve, which is part of auricular acupuncture therapy. It is well known that the auricular branch of the vagus nerve is the only peripheral pathway to the cerebral cortex. Studies of the Chinese team on hypertension, diabetes, epilepsy and depression have shown that the mechanism of auricular vagus nerve stimulation (VNS) may be comparable with cervical VNS in terms of pathways. Auricular VNS has a broad clinical application prospect.


Assuntos
Acupuntura Auricular , Pesquisa Biomédica , Animais , Áustria , China , Depressão/terapia , Terapia por Estimulação Elétrica , Eletroacupuntura , Eletroencefalografia , Epilepsia/terapia , Humanos , Cooperação Internacional , Reflexo/fisiologia , Nervo Vago/fisiologia
6.
Artigo em Inglês | MEDLINE | ID: mdl-26161121

RESUMO

To observe the effect of electroacupuncture (EA) on nucleus ventralis posterior lateralis (VPL) thalami activated by visceral noxious stimulation and to explore the impact of EA on the mechanism of acupoint sensitization under a pathological state of the viscera, EA was applied at bilateral "Zusanli-Shangjuxu" acupoints. The discharge of VPL neurons was response to EA increased after colorectal distension (CRD). The stimulation at "Zusanli-Shangjuxu" acupoints enhanced discharge activity of VPL neurons under CRD-induced visceral pain. The frequency of neuronal discharge was associated with the pressure gradient of CRD which showed that visceral noxious stimulation may intensify the body's functional response to stimulation at acupoints.

7.
Chin J Integr Med ; 19(12): 889-93, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24307308

RESUMO

Acupuncture point specificity is the theoretical basis for meridian and acupuncture theory. Also it is the key factor for the efficacy of acupuncture treatment. Studies on acupoint specifificity have aroused wide interest in scholars both at home and abroad. Some researchers abroad do not support acupoint specifificity. Chinese scholars have, after years of research, preliminarily confifirmed the existence of acupoint specifificity. However, there is still no conclusive evidence to support acupoint specificity in terms of its specific physiological foundation, underlying mechanism and laws. This paper summarizes and analyzes basic and clinical researches on acupoint specificity in biological structure, physiology and acupoint effect, provides clues for further studies and develops the theoretical basis for acupont specifificity.


Assuntos
Pontos de Acupuntura , Acupuntura/normas , China , Humanos
8.
Zhen Ci Yan Jiu ; 38(1): 7-13, 2013 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-23650793

RESUMO

OBJECTIVE: To observe the effect of electroacupuncture (EA) of auricular concha region (ACR), "Zusanli" (ST 36) and "Sanyinjiao"(SP 6) on abnormal skin barrier and color in streptozotocin (STZ)-induced type 2 diabetes mellitus (T 2 DM) rats so as to find a better therapeutic method. METHODS: Fifty male Sprague Dawley (SD) rats were randomized into control (n = 10), model (n = 13), EA-ST 36-SP 6 (n = 14) and EA-ACR (n = 13) groups. T 2 DM model was established by intraperitoneal injection of 1% STZ (50 mg/kg) and by feeding the animals with high-fat diet for 30 days. EA (15 Hz, 1 mA) was applied to bilateral "Zusanli" (ST 36), "Sanyinjiao" (SP 6) and ACR respectively for 30 min, once daily for 14 days. Multi Probe Adapter 9 skin measurement system (MPA 9) was used to measure the stratum corneum hydration (SCH), transepidermal water loss (TEWL), erythema index (El), melanin index (MI) and chromatic aberration values (L. a. b.) of the abdomenal and back (L1 - L6) skin, respectively. RESULTS: In comparison with the control group and pre-modeling, blood glucose contents of the model, EA-ST 36-SP 6 and EA-ACR groups were increased significantly (P < 0.01) after modeling. Compared with the model group, blood glucose levels of both EA-ST 36-SP 6 and EA-ACR groups were down-regulated apparently (P < 0.01) after treatment. Thirty days after modeling, the SCH, TEWL, EI, MI, L. and a. levels of the back skin, and the SCH and L. levels of the abdominal skin were decreased significantly (P < 0.05), while the level of b. in the back skin, and those of TEWL, EL, a. and b. of the abdominal skin increased considerably in the model group (P < 0.05). After EA, the levels of SCH, TEWL MI, L. a. and b. in the EA-ST 36-SP 6 group, SCH, TEWL, L. and b. in the EA-ACR group of the back skin, and SCH, L. and b. of both EAST 36-SP 6 and EA-ACR groups, as well as EI and a. of the EA-ST 36-SP 6 group of the abdominal skin were reversed remarkably (P < 0.05). No significant differences were found between the EA-ST 36-SP 6 and model groups in the levels of El of the back skin, TEWL and MI of the abdominal skin, and between the EA-ACR and model groups in the levels of SCH, EI, MI and a. of the back skin, and TEWL, EI, MI and a. of the abdominal skin (P > 0.05). In spite of a mildly better therapeutic effect of EA-ST 36-SP 6 in regulating some of the abovementioned indexes, no significant differences were found between the two EA groups in all the indexes (P > 0.05). CONCLUSION: EA of both ST 36-SP 6 and ACR can effectively down-regulate blood glucose level, suppress DM-induced decrease of SCH, TEWL, L. and a. of the back skin, and SCH of the abdominal skin, and down-regulate b. levels of the back and abdominal skin in T 2 DM rats, showing an improvement of the impaired skin barrier and color changes following EA intervention.


Assuntos
Diabetes Mellitus Tipo 2/fisiopatologia , Diabetes Mellitus Tipo 2/terapia , Eletroacupuntura , Pigmentação da Pele , Animais , Glicemia/metabolismo , Diabetes Mellitus Tipo 2/metabolismo , Modelos Animais de Doenças , Humanos , Masculino , Ratos , Ratos Sprague-Dawley , Pele/metabolismo , Água/metabolismo
9.
IEEE Trans Neural Netw Learn Syst ; 24(10): 1635-47, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24808600

RESUMO

A data-driven 3-D fuzzy-logic controller (3-D FLC) design methodology based on support vector regression (SVR) learning is developed for nonlinear spatially distributed dynamic systems. Initially, the spatial information expression and processing as well as the fuzzy linguistic expression and rule inference of a 3-D FLC are integrated into spatial fuzzy basis functions (SFBFs), and then the 3-D FLC can be depicted by a three-layer network structure. By relating SFBFs of the 3-D FLC directly to spatial kernel functions of an SVR, an equivalence relationship of the 3-D FLC and the SVR is established, which means that the 3-D FLC can be designed with the help of the SVR learning. Subsequently, for an easy implementation, a systematic SVR learning-based 3-D FLC design scheme is formulated. In addition, the universal approximation capability of the proposed 3-D FLC is presented. Finally, the control of a nonlinear catalytic packed-bed reactor is considered as an application to demonstrate the effectiveness of the proposed 3-D FLC.

10.
IEEE Trans Syst Man Cybern B Cybern ; 34(1): 788-95, 2004 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-15369124

RESUMO

Stability and design issues of simple T-S fuzzy control system with simplified linear rule consequent (TSS) are investigated. A systematic approach to find a common matrix P for TSS fuzzy system is presented, where system matrix Ai is decomposed into proportional part Ai and the remainder delta Ai. Hence an iterative approach to find a common matrix P for pairwise commutative Ai's can be used. The stability of the global system is guaranteed if delta Ai satisfies certain conditions. Qualitative instructions for TSS control system design are summarized. A physical example is given to illustrate the issues discussed throughout the paper.

11.
ISA Trans ; 42(2): 251-8, 2003 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-12708543

RESUMO

A suboptimal dual-mode solution to constrained nonlinear quadratic regulator (CNLQR) problem is studied. In a neighborhood of the origin, the controller is formulated as an LQR based on a model obtained by linearizing the original model at the origin. Outside this neighborhood, the control law is obtained by solving a finite horizon optimization problem (FHOP) with additional terminal inequality constraints. The terminal inequality constraints make the terminal states of FHOP be driven into the neighborhood of the origin, which is a specially designed control invariant set with respect to LQR control law. The overall control law is obtained by combining that obtained by solving FHOP and that obtained form LQR. The feasibility aspect is analyzed and asymptotic stability is proven. The effectiveness of this suboptimal controller is demonstrated by simulation studies.

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