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1.
Artigo em Inglês | MEDLINE | ID: mdl-33646472

RESUMO

A short-rod-shaped, non-spore-forming endophytic actinobacterium, was isolated from a surface-sterilized leaf of Acrostichum aureum in Fangchenggang, Guangxi Zhuang Autonomous Region, China, designated strain CBS4Y-1T and examined by a polyphasic approach to determine its taxonomic position. This actinobacterium was Gram-staining-positive and aerobic. Substrate mycelia and aerial mycelia were not observed, and no diffusible pigments were observed on the media tested. Strain CBS4Y-1T grew optimally with 0-1.0% (w/v) NaCl at 30 °C, pH 7.0-8.0. Comparative analysis of 16S rRNA genes showed that strain CBS4Y-1T shared the highest 16S rRNA gene sequence similarities with Nocardioides marinus CL-DD14T (96.7%) and Nocardioides terrae BX5-10T (96.7%). Phylogenetic analyses based on 16S rRNA gene sequence and phylogenomic analysis based on core proteomes alignment revealed that strain CBS4Y-1T belonged to the genus Nocardioides and formed a distinct cluster within the genus Nocardioides. The DNA G + C content of strain CBS4Y-1T was 71.1 mol%. The cell-wall peptidoglycan contained LL-diaminopimelic acid and MK-8(H4) was the predominant menaquinone. Phosphatidylglycerol (PG), diphosphatidylglycerol (DPG), phosphatidylinositol (PI) were detected in the polar lipid extracts. The major fatty acids were iso-C16:0, C18:1ω9c and iso-C17:0. On the basis of phylogenetic analysis, phenotypic and chemotaxonomic characteristics, strain CBS4Y-1T represents a novel species of the genus Nocardioides, for which the name Nocardioides acrostichi sp. nov. is proposed. The type strain is CBS4Y-1T (= KCTC 49238T = CGMCC 4.7548T).

2.
PLoS Pathog ; 17(2): e1009317, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33600488

RESUMO

The transmembrane protein 33 (TMEM33) was originally identified as an endoplasmic reticulum (ER) protein that influences the tubular structure of the ER and modulates intracellular calcium homeostasis. However, the role of TMEM33 in antiviral immunity in vertebrates has not been elucidated. In this article, we demonstrate that zebrafish TMEM33 is a negative regulator of virus-triggered interferon (IFN) induction via two mechanisms: mitochondrial antiviral signaling protein (MAVS) ubiquitination and a decrease in the kinase activity of TANK binding kinase 1 (TBK1). Upon stimulation with viral components, tmem33 was remarkably upregulated in the zebrafish liver cell line. The IFNφ1 promoter (IFNφ1pro) activity and mRNA level induced by retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) were significantly inhibited by TMEM33. Knockdown of TMEM33 increased host ifn transcription. Subsequently, we found that TMEM33 was colocalized in the ER and interacted with the RLR cascades, whereas MAVS was degraded by TMEM33 during the K48-linked ubiquitination. On the other hand, TMEM33 reduced the phosphorylation of mediator of IFN regulatory factor 3 (IRF3) activation (MITA)/IRF3 by acting as a decoy substrate of TBK1, which was also phosphorylated. A functional domain assay revealed that the N-terminal transmembrane domain 1 (TM1) and TM2 regions of TMEM33 were necessary for IFN suppression. Finally, TMEM33 significantly attenuated the host cellular antiviral capacity by blocking the IFN response. Taken together, our findings provide insight into the different mechanisms employed by TMEM33 in cellular IFN-mediated antiviral process.

3.
J Pharm Biomed Anal ; 197: 113949, 2021 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-33618131

RESUMO

Compatibility investigations are vital but also the most difficult aspect of traditional Chinese medicine (TCM) prescriptions. Previous researches have demonstrated that Xiaoyaosan (XYS) is an effective treatment for depression. However, the compatibility rules of XYS and the underlying mechanisms remain unclear. Herein, we combined network pharmacology and serum metabolomics to investigate the scientific connotations and the compatibility effects of XYS. First, the Traditional Chinese Medicine Systems Pharmacology (TCMSP) and the GeneCards databases were applied to identify the chemical components and the putative targets of XYS, and its efficacy groups. We then analyzed the herb-component-target pathways and constructed PPI networks. Potential pathways were determined by gene ontology (GO) and pathway enrichment analyses. Additionally, a chronic unpredictable mild stress (CUMS) model was applied on rats. A proton nuclear magnetic resonance spectrometry (1H NMR) based serum metabolomics was then used to identify potential metabolites and the corresponding pathways that were involved in depression and the potential anti-depression effects of XYS and its efficacy groups. A total of 121 components of XYS and 111 targets were associated with depression. Additionally, we screened 105 targets of 24 components in Shugan (SG) group and 106 targets of 95 components in Jianpi (JP) group. 13 targets were common to all three groups. Protein-protein interaction network analysis showed that Caspase-3 and Nitric oxide synthase-3 were nodes that overlapped with proteins known to be associated with depression. Pathway enrichment analysis further indicated that the putative targets of XYS and its efficacy groups mostly participated in pathways associated with cancer. Also, XYS and its efficacy groups significantly reversed abnormalities of serum metabolites and metabolic pathways, but to different degrees. Overall, different efficacy groups of XYS exhibit synergistic anti-depression effects and contribute to the whole prescription against depression. This study shows that the combination of network pharmacology and metabolomics is an effective approach to demonstrate scientific connotations and compatibility of TCMs from a holistic perspective.

4.
Artigo em Inglês | MEDLINE | ID: mdl-33541081

RESUMO

Piezocatalysis provides a promising strategy for directly converting weak mechanical energy into chemical energy. In this work, we report a simple one-step hydrogen reduction route for the simultaneous generation of surface defects and heterojunctions in Sr0.5Ba0.5Nb2O6 nanorods fabricated by a molten salt synthesis method. The as-fabricated Sr0.5Ba0.5Nb2O6/Sr2Nb2O7 nanocomposites with controllable oxygen vacancies exhibited excellent piezocatalytic activity under ultrasonic vibration, with an about 7 times enhancement of the rate constant (k = 0.0395 min-1) for rhodamine B degradation and an about 10 times enhancement of the water-splitting efficiency for hydrogen generation (109.4 µmol g-1 h-1) for the optimized sample (H2 annealed at 500 °C) compared to pristine Sr0.5Ba0.5Nb2O6 nanorods. This work demonstrates the essential role of a well-modulated oxygen vacancy concentration in the piezocatalytic activity and provides an inspiring guide for designing self-generated heterojunction piezocatalysts.

5.
Artigo em Inglês | MEDLINE | ID: mdl-33635070

RESUMO

Piezoelectric material-based catalysis that relies on an external stress-induced piezopotential has been demonstrated to be an effective strategy toward various chemical reactions. In this work, non-noble metal Ni-decorated ultralong monocrystal GaN nanowires (NWs) were prepared through a chemical vapor deposition (CVD) technique, followed by a photodeposition method. The piezocatalytic activity of the GaN NWs was enhanced by ∼9 times after depositing the Ni cocatalyst, generating hydrogen gas of ∼88.3 µmol·g-1·h-1 under ultrasonic vibration (110 W and 40 kHz), which is comparable to that of Pt-loaded GaN NWs. Moreover, Ni/GaN NWs with smaller diameters (∼100 nm) demonstrated superior piezocatalytic efficiency, which can be attributed to the large piezoelectric potential evidenced by both finite-element analysis and piezoresponse force microscopy measurements. These results demonstrate the promising application potential of non-noble metal loaded GaN nanostructures in hydrogen generation driven by weak mechanical energy from the surrounding environment.

6.
Chemphyschem ; 2021 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-33452853

RESUMO

The uneven lithium (Li) electrodeposition hinders the wide application of high-energy-density Li metal batteries (LMBs). Current efforts mainly focus on the side reaction suppression between Li and electrolyte, neglecting the determinant factor of mass transport in affecting Li deposition. Herein, the rearranged Li+ motions under the action of a local electric field near magnetic nanoparticles or structures imbedded Li surfaces, known as the magnetohydrodynamic (MHD) effect, are proposed to promote the mass transport for the uniform Li deposition. The modified Li+ trajectories are revealed by COMSOL Multiphysics simulations, and verified by the compact and disc-like Li depositions on a model Fe3O4 substrate. Furthermore, a patterned mesh with the magnetic Fe-Cr2O3 core-shell skeleton is used as a facile and efficient protective structure of Li metal anode, enabling Li metal batteries to achieve a Coulombic efficiency of 99.5% over 300 cycles at a high cathode loading of 5.0 mAh cm-2. The Li protection strategy based on the MHD interface design might open a new opportunity to develop high-energy-density LMBs.

7.
Chem Asian J ; 16(5): 378-396, 2021 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-33427380

RESUMO

Natural cellulose substances have been proven to be ideal structural templates and scaffolds for the fabrication of artificial functional materials with designed structures, psychochemical properties and functionalities. They possess unique hierarchically porous network structures with flexible, biocompatible, and environmental characteristics, exhibiting great potentials in the preparation of energy-related materials. This minireview summarizes natural cellulose-based materials that are used in batteries, supercapacitors, photocatalytic hydrogen generation, photoelectrochemical cells, and solar cells. When natural cellulose substances are employed as the structural template or carbon sources of energy materials, the three-dimensional porous interwoven structures are perfectly replicated, leading to the enhanced performances of the resultant materials. Benefiting from the mechanical strengths of natural cellulose substances, wearable, portable, free-standing, and flexible materials for energy storage and conversion are easily obtained by using natural cellulose substances as the substrates.

8.
Dev Comp Immunol ; 115: 103876, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32987012

RESUMO

In mammals, cyclic GMP-AMP synthase (cGAS) is a crucial cytosolic DNA sensor responsible for activating the interferon (IFN) response. A cGAS-like (cGASL) gene was previously identified from grass carp Ctenopharyngodon idellus, which is evolutionarily closest to cGAS but not a true ortholog of cGAS. Here, we found that grass carp cGASL targets mitochondrial antiviral signaling protein (MAVS) for autophagic degradation to negatively regulate fish IFN response. Firstly, the transcriptional level of cellular cgasl was upregulated by poly I:C stimulation, and overexpression of cGASL significantly decreased poly I:C- and MAVS-induced promoter activities and transcriptional levels of IFN and IFN-stimulated genes (ISGs). In addition, cGASL associated with MAVS and prompted autophagic degradation of MAVS in a dose-dependent manner. Finally, overexpression of cGASL attenuated MAVS-mediated cellular antiviral response. These results collectively indicate that cGASL negatively regulates fish IFN response by triggering autophagic degradation of MAVS.

9.
Dev Comp Immunol ; 114: 103805, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32755617

RESUMO

TANK-binding kinase 1 (TBK1) plays a vital role in activating interferon (IFN) production and positively regulating antiviral response in mammals. Research on more species of fish is necessary to clarify whether the function of fish TBK1 is conserved compared to that in mammals. Here, a cyprinid fish (Ancherythroculter nigrocauda) TBK1 (AnTBK1) was functionally identified and characterized. The full-length open reading frame (ORF) of AnTBK1 consists of 2184 nucleotides encoding 727 amino acids and contains a conserved Serine/Threonine protein kinase catalytic domain (S_TKc) in the N-terminal, similar to TBK1 in other species. The transcripts of AnTBK1 were found in all the tissues evaluated and the cellular distribution indicated that AnTBK1 was localized in the cytoplasm. In terms of functional identification, AnTBK1 induced a variety of IFN promoter activities as well as the expression of downstream IFN-stimulated genes (ISGs). In addition, AnTBK1 interacted with and significantly phosphorylated IFN regulatory factor 3 (IRF3), exhibiting the canonical kinase activity of TBK1. Finally, AnTBK1 presented strong antiviral activity against spring viremia of carp virus (SVCV) infection. Taken together, our research on the features and functions of AnTBK1 demonstrated that AnTBK1 plays a central role in IFN induction against SVCV infection.

10.
J Colloid Interface Sci ; 581(Pt A): 350-361, 2021 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-32771744

RESUMO

Adsorption and photocatalytic oxidation are promising technologies for eliminating antibiotics (e.g. tetracycline) in aquatic environments. However, traditional powdery nanomaterials are limited by drawbacks of difficult separation and lack of synergistic function, which do not conform to the practical demand. Herein, we developed a simple one-step gelation-pyrolysis route to fabricate hydrophilic three-dimensional (3D) porous photocatalytic adsorbent, in which CuO nanoparticles are uniformly and firmly embedded in nitrogen-doped (N-doped) porous carbon frameworks. The obtained N-doped carbon/CuO bulky composites exhibited excellent ability to adsorb tetracycline hydrochloride (TC), which was subsequently photo-oxidized under visible light. Their hydrophilic nature favors the adsorption processes toward TC, with a maximum adsorption capacity reaching 25.03 mg∙g-1. In addition, >94.4% of TC molecules could be photo-degraded in 4 h with good cycling efficiency after three consecutive tests. Finally, a reaction scheme for removal process of TC was proposed. The obtained 3D porous N-doped carbon/CuO nanocomposites show great promise for efficient removal of antibiotics in aqueous solution by synergistically utilizing adsorption and photocatalytic oxidation processes.

11.
J Stroke Cerebrovasc Dis ; 30(2): 105473, 2020 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-33276304

RESUMO

BACKGROUND AND PURPOSE: Current evidence does not agree on the merits of direct and bridging thrombectomy. This study aimed to compare the safety and efficacy of direct thrombectomy (DT) and bridging thrombectomy (BT) in treating patients with acute ischaemic stroke due to carotid T occlusion. METHODS: Patients with stroke due to carotid T occlusion who were treated with DT or BT were retrospectively collected from four advanced stroke centres. Baseline characteristics and clinical outcomes were compared between the groups. Successful recanalization was defined by a modified thrombolysis in cerebral infarction (mTICI) score of 2b or 3. A favourable outcome was defined by a modified Rankin Scale (mRS) score of 0-2 at 90 days after stroke onset. Multivariable analysis was performed to control for potential confounders. RESULTS: Of the 111 enrolled patients, 57 (51.4%) patients were treated with DT, and 54 (48.6%) were treated with BT. Patients treated with DT had a shorter imaging to puncture (ITP) time (53 min versus 92 min, P<0.001) and symptom onset to puncture (OTP) time (198 min versus 218 min, P=0.045) than patients treated with BT. No significant difference was detected concerning the rate of successful recanalization (80.7% versus 77.8%, P=0.704) or a favourable outcome between patients treated with DT and BT (35.1% versus 33.3%, P=0.846). Patients treated with DT had a lower intracranial haemorrhage (ICH) rate (40.4% versus 59.3%, P=0.046), but the difference was not significant for symptomatic ICH (sICH, 12.3% versus 16.7%, P=0.511) or asymptomatic ICH (aICH, 28.1% versus 42.6%, P=0.109). After adjusting for potential confounding factors, the ratio of favorable prognosis, successful reperfusion, sICH and mortality did not differ between the two groups. However, there was a higher rate of ICH (OR=2.492, 95% CI 1.005 to 6.180, p=0.049) in the BT group as compared with the DT group. CONCLUSIONS: DT seems equivalent to BT in treating stroke due to carotid T occlusion in favorable outcome, successful recanalization, 90-day morality and sICH. However, BT may increase the incidence of ICH in this specific type stroke.

12.
Neuropsychiatr Dis Treat ; 16: 2913-2920, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33293816

RESUMO

Purpose: Malignant cerebral edema (MCE) in patients undergoing endovascular thrombectomy (EVT) is not uncommon and can reduce the benefit of EVT. We aimed to develop a nomogram model to predict the risk of MCE in ischemic stroke patients after EVT. Patients and Methods: We retrospectively collected patients treated with EVT caused by anterior circulation large vessel occlusion stroke at two comprehensive stroke centers. MCE was defined as midline shift >5 mm at the septum pellucidum or pineal gland with obliteration of the basal cisterns or the need for early decompressive hemicraniectomy. A multivariate logistic model was utilized to construct the best-fit nomogram model. The discrimination and calibration of the nomogram were estimated using the area under the receiver operating characteristic curve (AUC-ROC) and Hosmer-Lemeshow test. Results: A total of 370 patients (mean age, 67.2±11.9 years; male, 56.8%) were enrolled in the final analysis. Among them, 71 (19.2%) patients experienced MCE after EVT treatment. After adjustment for potential confounders, age, baseline National Institutes of Health Stroke Scale score, collateral circulation, fast blood glucose level and recanalization were independent predictors of MCE and were incorporated into the nomogram. The AUC-ROC value of the nomogram was 0.805 (95% confidence interval [CI]: 0.750-0.860). The Hosmer-Lemeshow goodness-of-fit test showed good calibration of the nomogram (P = 0.681). Conclusion: The nomogram composed of age, baseline National Institutes of Health Stroke Scale score, blood glucose level, collateral circulation and recanalization may predict the probability of MCE in anterior circulation large vessel occlusion stroke patients treated with EVT.

13.
Parasit Vectors ; 13(1): 601, 2020 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-33261628

RESUMO

BACKGROUND: Schistosomiasis is a chronic, debilitating infectious disease caused by members of the genus Schistosoma. Previous findings have suggested a relationship between infection with Schistosoma spp. and alterations in the liver and spleen of infected animals. Recent reports have shown the regulatory role of noncoding RNAs, such as long noncoding RNAs (lncRNAs), in different biological processes. However, little is known about the role of lncRNAs in the mouse liver and spleen during Schistosoma japonicum infection. METHODS: In this study, we identified and investigated lncRNAs using standard RNA sequencing (RNA-Seq). The biological functions of the altered expression of lncRNAs and their target genes were predicted using bioinformatics. Ten dysregulated lncRNAs were selected randomly and validated in reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR) experiments. RESULTS: Our study identified 29,845 and 33,788 lncRNAs from the liver and spleen, respectively, of which 212 were novel lncRNAs. We observed that 759 and 789 of the lncRNAs were differentially expressed in the respective organs. The RT-qPCR results correlated well with the sequencing data. In the liver, 657 differentially expressed lncRNAs were predicted to target 2548 protein-coding genes, whereas in the spleen 660 differentially expressed lncRNAs were predicted to target 2673 protein-coding genes. Moreover, functional annotation showed that the target genes of the differentially expressed lncRNAs were associated with cellular processes, metabolic processes, and binding, and were significantly enriched in metabolic pathways, the cell cycle, ubiquitin-mediated proteolysis, and pathways in cancer. CONCLUSIONS: Our study showed that numerous lncRNAs were differentially expressed in S. japonicum-infected liver and spleen compared to control liver and spleen; this suggested that lncRNAs may be involved in pathogenesis in the liver and spleen during S. japonicum infection.

14.
J Org Chem ; 2020 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-33267579

RESUMO

The NaIO4-mediated sequential iodination/amidation reaction of N-alkyl quinolinium iodide salts has been first developed. This cascade process provides an efficient way to rapidly synthesize 3-iodo-N-alkyl quinolinones with high regioselectivity and good functional group tolerance. This protocol was also amenable to the isoquinolinium salts, thus providing a complementary method for preparing the 4-iodo-N-alkyl isoquinolinones.

15.
Biomed Res Int ; 2020: 8848189, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33354573

RESUMO

Objective: To investigate the influence of early bladder imaging (EBI) in experimental rabbits on the quantitative calculation of glomerular filtration rate (GFR) by the Gates method. Methods: We retrospectively analyzed the data of dynamic renal scintigraphy (DRS) in experimental rabbits. We calculated renal uptake during minutes 1-2 and 2-3 by correcting bladder radioactivity and computed the split GFR by renal uptake. Then, the EBI and GFR between 1-2 min and 2-3 min were compared, respectively. Results: The EBI proportion (57.3%) at 2-3 min of DRS was higher than that (8.5%) at 1-2 min (P < 0.05). The correlations between the 1-2 min and 2-3 min uptake rates of unobstructed kidneys after correction (r = 0.952-0.979) were higher than those before correction (r = 0.859-0.936). However, the correlation between the two in obstructed kidneys was not improved (r before = 0.967 versus r after = 0.968). For unobstructed kidneys, the difference in GFR based on 2-3 min uptake between before and after correction was significant (P < 0.05), but not in obstructed kidneys (P > 0.05). For GFR based on 1-2 min uptake, the difference between before and after correction was not significant in obstructed or unobstructed kidneys (P > 0.05). Before correction, the GFR of unobstructed kidneys of 10.5% of the rabbits in the protein load test was lower than that in the baseline status, but not so after correction. Conclusion: The 2-3 min EBI on DRS has a significant influence on the GFR calculated by the Gates method in experimental rabbits. Controlling water intake or calculating the GFR by 1-2 min renal uptake helps to avoid the influence of EBI on GFR.

17.
ACS Biomater Sci Eng ; 6(10): 5588-5598, 2020 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-33320589

RESUMO

Stiffening of the extracellular matrix (ECM) is considered a typical remolding of the microenvironment in multistep tumor progression. However, the molecular mechanisms by which the tumor cell responds to the ECM mechanical cues remain elusive. Here, we demonstrated that microRNA-29b (miR-29b) and its downstream signaling play critical regulatory roles that osteosarcoma cells sense the ECM stiffness to maintain the cancer stem cell-like ability. Polyacrylamide gels with a stiffness of 7, 20, and 55 kPa were used to mimic the rigidity of connective tissue, muscle tissue, and bone tissue. It was found that the stemness properties including self-renewal ability, differentiation potential, and drug resistance of osteosarcoma cells were strongly enhanced with reducing substrate stiffness, whereas spreading area, proliferation, and migration were inhibited. Moreover, miR-29 was obviously downregulated in soft substrate-cultured osteosarcoma cells, and the expression of stemness-related transcription factors (Sox2, Nanog, and Oct4) and the sphere formation ability were significantly inhibited by ectopic expression of miR-29b-5p. The soft substrate-induced miR-29 downregulation could increase Spin 1 expression and activate phosphatidylinositol 3-kinase (PI3K)/Akt and Stat3 signaling, which were suppressed by the increase in miR-29b-5p. Taken together, our results elucidated that miR-29 could be a novel mechanical sensor which manipulates osteosarcoma cell stemness. This finding uncovers the fact that the mechanical cue of the cancer niche could take part in the regulation of cancer progression through operating microRNAs and their downstream signaling.

18.
Aging (Albany NY) ; 13(2): 2294-2309, 2020 12 14.
Artigo em Inglês | MEDLINE | ID: mdl-33318304

RESUMO

BACKGROUND: Recent studies have demonstrated a complex and dynamic neural crosstalk between the heart and brain. A heart-brain interaction has been described regarding cardiac ischemia, but the cerebral metabolic mechanisms involved are unknown. METHODS: Male Sprague Dawley rats were randomly allocated into 2 groups: those receiving myocardial ischemia-reperfusion surgery (IR group, n =10) and surgical controls (Con group, n=10). These patterns of metabolic abnormalities in different brain regions were assessed using proton magnetic resonance spectroscopy (PMRS). RESULTS: Results assessed by echocardiography showed resultant cardiac dysfunction following heart ischemia-reperfusion. Compared with the control group, the altered metabolites in the IR group were taurine and choline, and differences mainly occurred in the thalamus and brainstem. CONCLUSIONS: Alterations in cerebral taurine and choline are important findings offering new avenues to explore neuroprotective strategies for myocardial ischemia-reperfusion injury. These results provide preliminary evidence for understanding the cerebral metabolic process underlying myocardial ischemia-reperfusion injury in rats.

19.
BMC Med ; 18(1): 334, 2020 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-33198801

RESUMO

BACKGROUND: ABO blood group is associated with differences in lifespan, cardiovascular disease, and some cancers, for reasons which are incompletely understood. To gain sex-specific additional insight about potential mechanisms driving these common conditions for future interventions, we characterized associations of ABO blood group antigen across the phenotype sex-specifically. METHODS: We performed a phenome-wide association study (PheWAS) assessing the association of tag single nucleotide polymorphisms (SNPs) for ABO blood group antigens (O, B, A1, and A2) with 3873 phenotypes. RESULTS: The tag SNP for the O antigen was inversely associated with diseases of the circulatory system (particularly deep vein thrombosis (DVT)), total cholesterol, low-density lipoprotein cholesterol (LDL-C), and ovarian cancer, and positively associated with erythrocyte traits, leukocyte counts, diastolic blood pressure (DBP), and healthy body composition; the tag SNP for the A1 antigen tended to have associations in reverse to O. Stronger associations were more apparent for men than women for DVT, DBP, leukocyte traits, and some body composition traits, whereas larger effect sizes were found for women than men for some erythrocyte and lipid traits. CONCLUSION: Blood group has a complex association with cardiovascular diseases and its major risk factors, including blood pressure and lipids, as well as with blood cell traits and body composition, with some differences by sex. Lower LDL-C may underlie some of the benefits of blood group O, but the complexity of associations with blood group antigen suggests overlooked drivers of common chronic diseases.

20.
Artigo em Inglês | MEDLINE | ID: mdl-33179405

RESUMO

In this work, we rationally designed a series of crystalline and ultrastable dioxin-linked metallophthalocyanine covalent organic frameworks (MPc-TFPN COF, M = Ni, Co, Zn) under the guidance of reticular chemistry. As a novel single-site catalysts (SSCs), NiPc/CoPc-TFPN COF exhibited outstanding activity and selectivity for electrocatalytic CO2 reduction (ECR) (Faradaic efficiency of CO (FECO) = 99.8(± 1.24) % / 96.1(± 1.25) % for NiPc/CoPc-TFPN COF). More importantly, when coupled with light, the FECO and current density (jCO) were further improved at all applied potential range (-0.6 to -1.2 V vs. RHE) compared to the dark environment for NiPc-TFPN COF (jCO increased from 14.1 to 17.5 A g-1 at -0.9 V; FECO reached up to ~100 % at -0.8 to -0.9 V). Furthermore, an in-depth mechanism study was established by density functional theory (DFT) simulation and experimental characterization. For the first time, this work explored the application of COFs as photo-coupled electrocatalysts to improve ECR efficiency, which showed the potential of using light-sensitive COFs in the field of electrocatalysis.

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