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1.
Zhonghua Yu Fang Yi Xue Za Zhi ; 54(4): 337-339, 2020 Apr 06.
Artigo em Chinês | MEDLINE | ID: mdl-32268633

RESUMO

COVID-19 continues to spread throughout the country, and the prevention and control of the epidemic has entered a critical period. However, southern cities with severe outbreaks are about to enter the seasonal influenza season. We should strengthen the epidemiological investigation, optimize the laboratory testing strategy, take effective measures, strengthen the prevention and control of influenza epidemic, and minimize the interference to the COVID-19 epidemic.


Assuntos
Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/epidemiologia , Influenza Humana/diagnóstico , Influenza Humana/epidemiologia , Influenza Humana/prevenção & controle , Pneumonia Viral/diagnóstico , Pneumonia Viral/epidemiologia , Betacoronavirus , China , Cidades , Humanos , Pandemias , Estações do Ano
2.
Zhonghua Wei Chang Wai Ke Za Zhi ; 23(4): 384-389, 2020 Apr 25.
Artigo em Chinês | MEDLINE | ID: mdl-32306607

RESUMO

Objective: To explore the safety and feasibility of da Vinci robot surgical systems in natural orifice specimen extraction surgery (NOSES) for rectal neoplasms. Methods: A descriptive cohort study was used. Inclusion criteria: (1) age ≥18 years old; (2) diagnosis of rectal cancer by biopsy via colonoscopy or benign neoplasm locating in rectum that could not be resected locally through the anus; (3) R0 resection can be achieved by preoperative evaluation; (4) the CDmax (maximum circumferential diameter) was ≤5 cm or specimens could still be extracted from the anus despite a CDmax exceeding 5 cm but was along the longitudinal axis of the rectum. Exclusion criteria: (1) emergency operation due to gastrointestinal obstruction, perforation, or bleeding; (2) distal metastasis, induding lung, bone, or liver, that could not be resected simultaneously; (3) history of abdominal surgery or any other contraindications for robotic surgery. Clinicopathological data of 162 patients with rectal neoplasms who underwent robotic NOSES at the General Surgery Department of the Second Xiangya Hospital of Central South University from March 2016 to July 2019 were retrospectively collected. Of 162 patients, 94 were male and 68 were female; the average age was (57±13) years; the average BMI was (23.5±3.2) kg/m(2); the average distance from tumor to the anal verge was (8.2±2.9) cm. Five trocars were used to perform total mesorectal excision (TME), and the descending colon artery was preserved. Sterile endoscope sleeve for the specimen extraction was inserted into the pelvic cavity through the anus, and the resected specimen was pulled out through the sleeve. Outcomes of safety (operation time, intraoperative blood loss and postoperative morbidity of complication) and oncological outcomes (number of lymph nodes harvested, rate of lymph node metastasis and rate of positive resection margin) were collected. Results: All the 162 cases completed robotic NOSES successfully with no conversion to laparotomy. The average operation time was (188.7±79.8) minutes; the average blood loss was (47.1±33.2) ml; the average and the maximum CDmax of specimens were (3.4±1.5) cm and 12 cm respectively. A total of 154 patients underwent robotic TME. One underwent robotic TME plus resection of liver metastasis; one underwent robotic TME plus partial transverse colectomy; two patients underwent robotic TME plus ovariectomy; another two underwent robotic TME plus hysterectomy; one patient underwent robotic TME plus left partial nephrectomy due to renal angioleiomyoma; another one underwent robotic TME plus ureteral repair due to intraoperative injury of the left ureter. All the specimens were extracted through the anus. Protective ileostomy was performed in 6.8% (11/162) of the patients. The average number of lymph node harvested was 14.9±5.1. According to pathological reports, 156 neoplasms were adenocarcinoma. Tis stage was 1.3% (2/156), T1 stage was 9.0% (14/156), T2 stage was 26.3% (41/156), T3 stage was 35.9% (56/156), and T4 stage was 27.6% (43/156). Lymph node metastasis accounted for 34.6% (54/156), and simultaneous liver metastasis was observed in one case. Circumferential resection margins (CRMs) and upper and lower resection margins were negative in all the patients. The average postoperative feeding time and postoperative hospital stay were (4.2±4.1) days and (11.4±7.7) days, respectively. Postoperative morbidity of complication was 12.3% (20/162). The incidence of anastomotic leakage was 4.9% (8/162), of which only 4 cases (2.5%) received ileostomy. Within postoperative 90-day, no anal dysfunction or death were found. Conclusion: Robotic NOSES for rectal neoplasms is safe and feasible.


Assuntos
Adenocarcinoma/cirurgia , Cirurgia Endoscópica por Orifício Natural/métodos , Protectomia/métodos , Neoplasias Retais/cirurgia , Procedimentos Cirúrgicos Robóticos , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento
3.
Zhonghua Liu Xing Bing Xue Za Zhi ; 41(3): 358-362, 2020 Mar 10.
Artigo em Chinês | MEDLINE | ID: mdl-32294835

RESUMO

Objective: To investigate the epidemiological and clinical characteristics of a case infected with avian influenza A (H5N6) virus associated with exposure to aerosol and provide evidence for the prevention and control of human infection with avian influenza virus. Methods: Epidemiological investigation was conducted to identify the history of exposure, infection route, and disease progression. Real-time fluorescent quantitative RT-PCR was used to test the samples collected from the case, close contacts, environment and poultry market. Results: The case had no history of exposure to live poultry and poultry market. But before the onset the case had a history of exposure to the live poultry placed in a car with doors and windows closed. The samples collected from the case's lower respiratory tract and the remaining frozen chicken meat were all influenza A (H5N6) virus positive. Conclusions: The source of infection was the live poultry, and the infection route might be the exposure to aerosol in a car with doors and windows closed, where the poultry were temporarily stored. It is necessary to promote centralized poultry slaughtering, cold chain distribution and fresh poultry sale, as well as strengthen health education and establish the concept of consuming fresh poultry.


Assuntos
Aerossóis/efeitos adversos , Vírus da Influenza A , Influenza Aviária/transmissão , Influenza Humana/epidemiologia , Animais , China/epidemiologia , Humanos , Aves Domésticas
4.
Zhonghua Liu Xing Bing Xue Za Zhi ; 41(5): 634-637, 2020 May 10.
Artigo em Chinês | MEDLINE | ID: mdl-32159317

RESUMO

Objective: By analyzing the epidemic characteristics and related indicators of SARS and COVID-19, to explore the reasons for the similarities and differences of the two epidemics, so as to provide reference for epidemic prevention and control. Methods: The general situation, clinical classification, activity history, contact history, family members' contact and incidence of the two infectious diseases in Guangzhou were collected and used to analyze the time characteristics, occupational characteristics, age characteristics and other key indicators of the two diseases, including the number of cases, composition ratio (%), mean, median, crude mortality, etc. Results: A total of 1 072 cases of SARS were included in the study. Three hundred and fifty three were severe cases with the incidence of 30.13%. Forty three cases of death were reported with a mortality rate of 4.01%. The average age was 46 years old, and 26.31% of the cases were medical staff. The interval time between first report to continuous zero reports was 129 days. As to COVID-19, a total of 346 cases were included. 58 of which were severe cases with the incidence of 16.67%. One case of death was reported with a mortality rate of 0.29%. The average age was 38 years old, and no hospital infection among medical staff was reported. The interval time between first report to continuous zero reports was 35 days. Conclusions: The prevention and control strategies for COVID-19 were more effective compared to that of SARS, and the emergency response procedures were worth to be evaluated and summarized.


Assuntos
Infecções por Coronavirus/epidemiologia , Epidemias , Pneumonia Viral/epidemiologia , Síndrome Respiratória Aguda Grave/epidemiologia , Adulto , China/epidemiologia , Humanos , Pessoa de Meia-Idade , Pandemias
5.
Zhonghua Yu Fang Yi Xue Za Zhi ; 54(0): E002, 2020 Feb 11.
Artigo em Chinês | MEDLINE | ID: mdl-32040985

RESUMO

The novel coronavirus pneumonia (NCP) continues to spread throughout the country, and the prevention and control of the epidemic has entered a critical period. However, southern cities with severe outbreaks are about to enter the seasonal influenza season. We should strengthen the epidemiological investigation, optimize the laboratory testing strategy, take effective measures, strengthen the prevention and control of influenza epidemic, and minimize the interference to the new coronavirus epidemic.

6.
Epidemiol Infect ; 147: e207, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-31364544

RESUMO

To compare the epidemiologic features (e.g. settings and transmission mode) and patient clinical characteristics associated with outbreaks of different norovirus (Nov) strains, we retrospectively analysed data of Nov outbreaks occurring in Guangzhou, China from 2012 to 2018. The results suggested that outbreaks of Nov GII.2, GII.17 and GII.4 Sydney exhibited different outbreak settings, transmission modes and symptoms. GII.2 outbreaks mainly occurred in kindergartens, elementary and high schools and were transmitted mainly through person-to-person contact. By contrast, GII.4 Sydney outbreaks frequently occurred in colleges and were primarily associated with foodborne transmission. Cases from GII.2 and GII.17 outbreaks reported vomiting more frequently than those from outbreaks associated with GII.4 Sydney.


Assuntos
Infecções por Caliciviridae/epidemiologia , Infecções por Caliciviridae/virologia , Surtos de Doenças , Genótipo , Norovirus/classificação , Norovirus/genética , Adolescente , Adulto , Infecções por Caliciviridae/patologia , Infecções por Caliciviridae/transmissão , Criança , Pré-Escolar , China/epidemiologia , Transmissão de Doença Infecciosa , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Norovirus/isolamento & purificação , Estudos Retrospectivos , Adulto Jovem
7.
Zhonghua Liu Xing Bing Xue Za Zhi ; 39(12): 1570-1575, 2018 Dec 10.
Artigo em Chinês | MEDLINE | ID: mdl-30572380

RESUMO

Objective: To understand the epidemiological and molecular characteristics of a norovirus- borne outbreak caused by GⅡ.4 Sydney 2012 in a university of Guangzhou to provide evidence for the prevention and control strategy on norovirus-caused epidemics. Methods: A self-designed questionnaire was used to collect clinical information from the patients as well as other data related to the epidemic. Pathogen detections were performed through anal swab specimens from the patients, kitchen workers and samples from the environment. Positive samples were further sequenced for phylogenetic analysis. A case-control study was employed to identify the risk factors related to this outbreak. Results: A total of 226 cases of norovirus-borne infection were identified between September 17 and 21, 2017, including 223 students, with an attack rate of 0.73% (223/30 711), and 3 kitchen workers. Students staying in the A dormitory area had the highest attack rate (1.73%, 164/9 459). No clustering was found in different colleges or classes. Results from the case-control study revealed that people who ate at the canteen in A dormitory area during September 18 to 20 was at risk for the onset of illness (OR=10.75, 95%CI: 5.56-20.79). The highest risk was related to the dinner on September 18. Another significant risk factor (OR=3.65, 95%CI: 1.92-6.94) was close personal contact in the same room of the dorm. The 3 norovirus infected kitchen workers were all from the canteen in A dormitory area where the positive rate of norovirus identified in kitchen workers was 26.67% (12/45). Positive samples were sequenced and sub-typed with results showing that the GⅡ.4 Sydney 2012 variant and the nucleotide sequences of cases and kitchen workers were 100% identical. Conclusions: The outbreak was caused by norovirus GⅡ.4 Sydney 2012 variant at campus. Similar outbreaks had been seen since 2013, with the routes of transmission most likely due to food-borne or personal contact.


Assuntos
Infecções por Caliciviridae/epidemiologia , Surtos de Doenças , Doenças Transmitidas por Alimentos/epidemiologia , Gastroenterite/epidemiologia , Norovirus/isolamento & purificação , Adolescente , Adulto , Estudos de Casos e Controles , China/epidemiologia , Feminino , Doenças Transmitidas por Alimentos/virologia , Gastroenterite/diagnóstico , Gastroenterite/virologia , Humanos , Masculino , Filogenia , Inquéritos e Questionários
8.
Zhonghua Liu Xing Bing Xue Za Zhi ; 39(6): 799-804, 2018 Jun 10.
Artigo em Chinês | MEDLINE | ID: mdl-29936750

RESUMO

Objective: To investigate the infection pattern and etiological characteristics of a case of human infection with highly pathogenic avian influenza A (H7N9) virus and provide evidence for the prevention and control of human infection with highly pathogenic avian influenza virus. Methods: Epidemiological investigation was conducted to explore the case's exposure history, infection route and disease progression. Samples collected from the patient, environments and poultry were tested by using real time reverse transcriptase-polymerase chain reaction (RT-PCR). Virus isolation, genome sequencing and phylogenetic analysis were conducted for positive samples. Results: The case had no live poultry contact history, but had a history of pulled chicken processing without taking protection measure in an unventilated kitchen before the onset. Samples collected from the patient's lower respiratory tract, the remaining frozen chicken meat and the live poultry market were all influenza A (H7N9) virus positive. The isolated viruses from these positive samples were highly homogenous. An insertion which lead to the addition of multiple basic amino acid residues (PEVPKRKRTAR/GL) was found at the HA cleavage site, suggesting that this virus might be highly pathogenic. Conclusions: Live poultry processing without protection measure is an important infection mode of "poultry to human" transmission of avian influenza viruses. Due to the limitation of protection measures in live poultry markets in Guangzhou, it is necessary to promote the standardized large scale poultry farming, the complete restriction of live poultry sales and centralized poultry slaughtering as well as ice fresh sale.


Assuntos
Subtipo H7N9 do Vírus da Influenza A/patogenicidade , Influenza Aviária/transmissão , Influenza Aviária/virologia , Influenza Humana/transmissão , Influenza Humana/virologia , Aves Domésticas/virologia , Animais , Galinhas , China , Comércio , Humanos , Subtipo H7N9 do Vírus da Influenza A/isolamento & purificação , Influenza Aviária/prevenção & controle , Influenza Humana/prevenção & controle , Filogenia , Reação em Cadeia da Polimerase em Tempo Real , Zoonoses
9.
Zhonghua Liu Xing Bing Xue Za Zhi ; 39(2): 204-207, 2018 Feb 10.
Artigo em Chinês | MEDLINE | ID: mdl-29495206

RESUMO

Objective: To study the willingness and influence factors related to "centralized slaughtering, fresh poultry listing and marketing" strategy, among the household chefs, and provide reference for government to adjust and optimize the strategy on avian influenza prevention. Methods: According to the geographical characteristics and regional functions, 6 'monitoring stations' were selected from 12 residential districts of Guangzhou, respectively. Another 21 meat markets which selling live poultry, were selected in each station and 5 household chefs of each market were invited to attend a face to face interview. Basic information, personal cognitive, willingness and influencing factors to the policy were under study. Univariate and multivariate logistic regression methods were used. Results: A total of 664 household chefs underwent the survey and results showed that the rate of support to the "centralized slaughtering, fresh poultry listing and marketing" strategy was 44.6% (296/664). Results from the multi-factor logistic regression showed that those household chefs who were males (OR=1.618, 95% CI: 1.156-2.264, P=0.005), having received higher education (OR=1.814, 95% CI: 1.296-2.539, P=0.001), or believing that the existence of live poultry stalls was related to the transmission of avian influenza (OR=1.918, 95% CI: 1.341-2.743, P<0.001) were factors at higher risk. These household chefs also intended to avoid the use of live poultry stalls (OR=1.666, 95%CI: 1.203-2.309, P=0.002) and accept the "centralized slaughtering, fresh poultry listing and marketing" strategy. Conclusion: Detailed study on this subject and, setting up pilot project in some areas as well as prioritizing the education programs for household chefs seemed helpful to the implementation of the 'freezing-fresh poultry' policy.


Assuntos
Atitude Frente a Saúde , Subtipo H7N9 do Vírus da Influenza A , Influenza Humana/prevenção & controle , Marketing , Indústria de Embalagem de Carne , Aves Domésticas/virologia , Animais , China , Humanos , Influenza Aviária , Masculino , Análise Multivariada , Projetos Piloto , Inquéritos e Questionários
10.
Zhonghua Liu Xing Bing Xue Za Zhi ; 38(6): 693-695, 2017 Jun 10.
Artigo em Chinês | MEDLINE | ID: mdl-28647965

RESUMO

In recent years, great effort has been made in the promotion of health for all in China. Articles on column on chronic and non-communicable disease risk factors in Uighur population, analysis based on the investigation results of Uygur population health status in the Kashi area of Xinjiang of China and similar domestic and foreign studies showed that the health data in different countries are different. The differences in health related data exist in different ethnic groups even in same country or same ethnic group in different areas. Only by fully understanding the differences in disease and related factors among different ethnic groups, developing individualized health indicators and conducting targeted intervention, the goal of health for all can be achieved.


Assuntos
Grupos Étnicos , Necessidades e Demandas de Serviços de Saúde , Atenção , China , Feminino , Humanos , Fatores de Risco
11.
Clin Microbiol Infect ; 7(4): 187-92, 2001 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11422240

RESUMO

OBJECTIVE: To investigate the situation among Chinese patients with regard to infection with multiple strains of Helicobacter pylori. METHODS: Biopsy specimens for culture of H. pylori were obtained from gastric antrum, body and fundus of 20 patients during endoscopic investigation of upper gastrointestinal symptoms. H. pylori was identified by culture from one site in 16 and two or more sites in 10 of the 16 patients. Five isolated colonies of six strains of H. pylori from gastric antrum were subcultured and used for further analysis. Antibiotic susceptibility to metronidazole and clarithromycin was determined by disk diffusion test. Protein profiles of isolates were compared by sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS-PAGE). DNA diversity of the isolates was determined by arbitrarily primed polymerase chain reaction (AP-PCR) fingerprinting. RESULTS: Of the 10 patients with multiple isolates, 70% (7/10) exhibited variation in susceptibility to metronidazole and 20% (2/10) to clarithromycin between different sites. In 83% of (5/6) single colonies, no variability was seen in metronidazole and clarithromycin susceptibility; they were either susceptible or resistant. Protein profiles of all isolates by SDS-PAGE were similar. Isolates from different patients produced clearly different AP-PCR fingerprints. In 50% of H. pylori strains isolated from different sites of the stomach, genetic diversity was demonstrated by different AP-PCR fingerprints. In 67% (4/6) strains, five single-colony fingerprints were similar. CONCLUSIONS: Genetic variability has been found in H. pylori strains. Individual patients are infected with a single predominant genotype at a single site but can be colonized by multiple strains, and they may show different antibiotic susceptibilities. Individual colonies of the H. pylori population from a single site may not always yield identical DNA fingerprints and antibiotic sensitivities.


Assuntos
Antibacterianos/farmacologia , Infecções por Helicobacter/microbiologia , Helicobacter pylori/classificação , Estômago/microbiologia , Adulto , China , Claritromicina/farmacologia , Resistência Microbiana a Medicamentos , Eletroforese em Gel de Poliacrilamida , Feminino , Variação Genética , Infecções por Helicobacter/diagnóstico , Helicobacter pylori/efeitos dos fármacos , Helicobacter pylori/genética , Helicobacter pylori/isolamento & purificação , Humanos , Masculino , Metronidazol/farmacologia , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase
12.
Indian J Lepr ; 73(1): 1-10, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11326592

RESUMO

Leprosy patients treated formerly with dapsone monotherapy followed by combined therapy with rifampicin plus dapsone were surveyed for relapse and rifampicin resistance. The relapse rate was significantly low for the 482 multibacillary (MB) patients receiving > 12 months combined therapy compared with the 49 MB cases receiving < 12 months of combined therapy. The relapse rate was related to the duration of dapsone monotherapy prior to combined therapy. The difference in relapse rate in 247 paucibacillary (PB) patients following > 12 months combined therapy was also of significance, compared with the 66 PB cases who had received < 12 months combined therapy. Five strains of M. leprae isolated from relapsed patients were sensitive to rifampicin by mouse foot-pad test and all relapsed patients responded favourably to fixed duration MDT regimen for MB cases.


Assuntos
Dapsona/uso terapêutico , Hansenostáticos/uso terapêutico , Hanseníase/tratamento farmacológico , Rifampina/uso terapêutico , Animais , Dapsona/administração & dosagem , Quimioterapia Combinada , Humanos , Hansenostáticos/administração & dosagem , Hanseníase/prevenção & controle , Camundongos , Testes de Sensibilidade Microbiana , Mycobacterium leprae/efeitos dos fármacos , Rifampina/administração & dosagem , Prevenção Secundária
13.
APMIS ; 108(7-8): 482-6, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-11167543

RESUMO

To determine whether there is diversity among clinical isolates of Helicobacter pylori in Chinese patients with peptic ulcer disease, 40 strains of H. pylori were isolated from antral biopsy specimens obtained at the gastroenterology clinic of Xiangya Hospital from January 1996 to June 1998. Total protein profile by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and DNA diversity by polymerase chain reaction-random amplified polymorphic DNA (PCR-RAPD) fingerprinting were performed with these isolates. All the isolates from peptic ulcer disease were relatively homogeneous in protein profiles, but they showed a great DNA sequence diversity by PCR-RAPD fingerprinting. In Chinese patients H. pylori demonstrated an enormous diversity. The diversity among clinical isolates of H. pylori could be distinctly demonstrated and this observation will be helpful in the management of intrafamilial and recurrent H. pylori infection. PCR-RAPD fingerprinting is an efficient method of distinguishing between clinical isolates of H. pylori.


Assuntos
Úlcera Duodenal/microbiologia , Variação Genética , Infecções por Helicobacter/microbiologia , Helicobacter pylori/genética , Úlcera Gástrica/microbiologia , Adulto , Proteínas de Bactérias/análise , China , Impressões Digitais de DNA , Úlcera Duodenal/patologia , Eletroforese em Gel de Poliacrilamida/métodos , Feminino , Gastroscopia/métodos , Infecções por Helicobacter/diagnóstico , Infecções por Helicobacter/patologia , Helicobacter pylori/classificação , Helicobacter pylori/isolamento & purificação , Humanos , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase/métodos , Técnica de Amplificação ao Acaso de DNA Polimórfico , Reprodutibilidade dos Testes , Dodecilsulfato de Sódio , Úlcera Gástrica/patologia
14.
Hunan Yi Ke Da Xue Xue Bao ; 25(4): 371-2, 2000 Aug 28.
Artigo em Chinês | MEDLINE | ID: mdl-12206006

RESUMO

To investigate whether sheep blood could be replaced with human serum or fetal calf serum for Helicobacter pylori(Hp) culture, Hp was inoculated onto the culture plates containing 7% of sheep blood, human serum, or fetal calf serum respectively. The colonies were counted after 5 days of culture. Similar culture results were obtained in the plates containing sheep blood, human serum, or fetal calf serum respectively. No effect of anti-Hp-IgG antibody in human serum on the growth of Hp was found (P > 0.05). However, heat-inactivated human serum significantly suppressed the growth of Hp (P < 0.01). Human serum or fetal calf serum may be used for Hp culture where sheep blood is not available. Bactericidal activity against Hp in human serum is mediated by complements.


Assuntos
Helicobacter pylori/crescimento & desenvolvimento , Animais , Anticorpos Antibacterianos/sangue , Bovinos , Meios de Cultura , Helicobacter pylori/imunologia , Humanos , Imunoglobulina G/sangue , Plasma , Ovinos
15.
J Gastroenterol Hepatol ; 13(11): 1096-8, 1998 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-9870794

RESUMO

The survival capacity of Helicobacter pylori in artificially contaminated milk and tap water was investigated in the study. Helicobacter pylori could survive for up to 10 days in milk at 4 degrees C storage but only 4 days in tap water with a steady decrease of colony forming units. However, electron microscopy clearly showed that the non-culturable coccoid form was present in tap water which had been kept at 4 degrees C for 7 days. It is concluded that H. pylori may survive in tap water as well as in milk, with the implication that they may, thereby, act as a vehicle of transmission.


Assuntos
Helicobacter pylori/crescimento & desenvolvimento , Leite/microbiologia , Microbiologia da Água , Animais , Humanos , Masculino , Microscopia Eletrônica , Pessoa de Meia-Idade , Temperatura
16.
Br J Biomed Sci ; 55(3): 176-8, 1998 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-10367401

RESUMO

Helicobacter pylori infection has been investigated extensively in immunocompromised hosts, such as those with acquired immunodeficiency syndrome (AIDS) and organ transplant recipients. However, few reports on H. pylori prevalence in individuals with chronic HBV infection are available. The aim of this serological study is to investigate H. pylori prevalence in patients with hepatitis B. Ninety-six consecutive hospitalised patients with chronic hepatitis B were studied, together with 104 age-matched healthy individuals of similar socioeconomic status and with no evidence of hepatitis B virus infection or liver diseases. Serum samples from both groups were tested for specific IgG antibodies to H. pylori, using enzyme-linked immunosorbent assay (ELISA). Of the 96 patients with hepatitis B, 55 (57.3%) were positive for serum IgG anti-H. pylori, significantly greater than in the control group of 104, where 44 (42.3%) were positive (P < 0.05). In addition, the seroprevalence of H. pylori in the 45 patients who were positive for hepatitis B envelope antigen (HBeAg) and/or HBV-DNA was 75.6% (34), compared to 41.2% (21) in the 51 patients who were negative (P < 0.005). An increase in H. pylori prevalence is present in patients with chronic hepatitis B. Further study is needed to determine whether eradication of H. pylori will benefit these patients.


Assuntos
Infecções por Helicobacter/complicações , Helicobacter pylori , Hepatite B Crônica/complicações , Infecções Oportunistas/complicações , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Soroepidemiológicos
17.
J Med Microbiol ; 46(4): 354-5, 1997 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-9128201

RESUMO

Culture of Helicobacter pylori requires micro-aerobic conditions which are usually generated by a commercial gas-generator system. However, the commercial gas-generator pack is not available in most hospitals in developing countries. The present study showed that H. pylori grew well in a candle jar system that provided micro-aerobic condition; this gave similar cultural results to a commercial gas-generator system. Therefore, the candle jar system can be used for H. pylori micro-aerobic culture in developing countries where commercial systems are not available.


Assuntos
Infecções por Helicobacter/microbiologia , Helicobacter pylori/crescimento & desenvolvimento , Adulto , Biópsia , Países em Desenvolvimento , Úlcera Duodenal/microbiologia , Feminino , Gastrite/microbiologia , Infecções por Helicobacter/patologia , Helicobacter pylori/efeitos dos fármacos , Humanos , Umidade , Masculino , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Antro Pilórico/microbiologia , Antro Pilórico/patologia
18.
Biol Psychiatry ; 20(8): 906-17, 1985 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-4040777

RESUMO

A study of hand preference and eye dominance in schizophrenia, manic-depressive psychosis, and normal controls was carried out in the People's Republic of China. An excess of sinistrality was found in both men and women schizophrenics, but not in manic-depressive patients. Both the manic-depressive and schizophrenic psychoses are characterized by a significant excess of left eye dominance and by an increasing divergence between eye and hand dominance when compared to the controls. The major published studies investigating hand preference in psychopathology are reviewed, and possible interpretations of the conflicting findings are suggested.


Assuntos
Transtorno Bipolar/fisiopatologia , Dominância Cerebral/fisiologia , Esquizofrenia/fisiopatologia , Adolescente , Adulto , Idoso , Epilepsia do Lobo Temporal/complicações , Epilepsia do Lobo Temporal/fisiopatologia , Feminino , Lateralidade Funcional , Humanos , Masculino , Pessoa de Meia-Idade , Fenômenos Fisiológicos Oculares , Gravidez , Esquizofrenia/complicações , Gêmeos Monozigóticos
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