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1.
Cancer Sci ; 2020 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-32012389

RESUMO

GINS complex subunit 4 (GINS4), is essential for DNA replication initiation and elongation in G1/S phase cell cycle in eukaryotes, in which, its functional roles and molecular mechanisms remain unclear in many aspects. Our study was determined to investigate the clinical significance, biological function and molecular mechanism of GINS4 in colorectal cancer (CRC). Here, we firstly confirmed that GINS4 expression was significantly overexpressed in CRC cells and tissues. The Immunohistochemical (IHC) results in tissue microarray (TMA) from 106 CRC patients demonstrated that high level of GINS4 expression was positively correlated with advanced T stage, higher tumor TNM stage and poor differentiation. The results from univariate and multivariate survival analysis models based on 106 CRC patients revealed that GINS4 might serve as an independent prognostic indicator for overall survival (OS) and disease-free survival (DFS) of CRC patients. Moreover, down-regulated GINS4 can inhibit growth and cell cycle and accelerate cell apoptosis progression in vitro as well as inhibit tumorigenesis in vivo. Besides, our results also indicated that Krüppel-like factor 4 (KLF4) can negatively regulate GINS4 expression in transcriptional level and KLF/GINS4 pathway might play a vital role in growth and prognosis of CRC.

2.
J Hazard Mater ; 389: 122130, 2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-31978824

RESUMO

The effects of varying concentrations of Ag NPs on coupled nitrification and denitrification (CND) in two suspended sediments (SPSs) sizes were investigated using isotopic tracer method. In general, 0.5 and 5 mg/L Ag NPs had less effect on CND, while 2 and 10 mg/L Ag NPs exhibited the improvement and inhibition effect, respectively. The CND improvement by 2 mg/L NPs was mainly due to the enhanced nitrifying and denitrifying enzyme activity. However, 10 mg/L Ag NPs inhibited NH4+ oxidation by directly reducing the AMO activity and AOB abundance. The inhibition on NAR and NIR activity and their encoding narG and nirK gene abundance further inhibited NO3- and NO2- reduction, leading to a dramatic decrease in the 15N-N2 production. The above inhibition effects were attributed to the nano-effects of Ag NPs, which led to the excessive ROS amount and the decreased T-AOC level in microbial systems. But the connection between nitrification and denitrification was not broken after Ag NPs exposure. Moreover, the results indicated that N-cycling in clay and silt-type SPS systems could be more sensitive than sand-type SPS systems to NP exposure. The findings provide a basis for evaluating the environmental risks of Ag NPs in water-sediment systems.

3.
BMC Bioinformatics ; 21(1): 12, 2020 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-31918656

RESUMO

BACKGROUND: Gene regulatory networks (GRNs) can be inferred from both gene expression data and genetic perturbations. Under different conditions, the gene data of the same gene set may be different from each other, which results in different GRNs. Detecting structural difference between GRNs under different conditions is of great significance for understanding gene functions and biological mechanisms. RESULTS: In this paper, we propose a Bayesian Fused algorithm to jointly infer differential structures of GRNs under two different conditions. The algorithm is developed for GRNs modeled with structural equation models (SEMs), which makes it possible to incorporate genetic perturbations into models to improve the inference accuracy, so we name it BFDSEM. Different from the naive approaches that separately infer pair-wise GRNs and identify the difference from the inferred GRNs, we first re-parameterize the two SEMs to form an integrated model that takes full advantage of the two groups of gene data, and then solve the re-parameterized model by developing a novel Bayesian fused prior following the criterion that separate GRNs and differential GRN are both sparse. CONCLUSIONS: Computer simulations are run on synthetic data to compare BFDSEM to two state-of-the-art joint inference algorithms: FSSEM and ReDNet. The results demonstrate that the performance of BFDSEM is comparable to FSSEM, and is generally better than ReDNet. The BFDSEM algorithm is also applied to a real data set of lung cancer and adjacent normal tissues, the yielded normal GRN and differential GRN are consistent with the reported results in previous literatures. An open-source program implementing BFDSEM is freely available in Additional file 1.

4.
Micron ; 130: 102820, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31901734

RESUMO

In order to solve the problem of where, why, and how to start pitting, it is necessary to study the influence of different dissolution activity of the internal heterogeneous structures of the complex inclusions. In this paper, mechanism of internal activity difference of two typical Yttrium composite inclusions on pitting corrosion is revealed from atomic scale by using immersion test, FE-SEM/EDS analysis and first-principles calculations. The results show that, for Mg-Y-S composite inclusions, pitting potential is lower than that of the matrix, therefore, The matrix around the composite inclusions dissolves preferentially; for Y-S-O composite inclusions with core-shell structure, Y-O inclusions in the shell are deformed and cracked due to the internal stress of the matrix and Y-S during the immersion process, resulting in the simultaneous dissolution of inclusions and steel matrix.

5.
World Neurosurg ; 2020 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-31954903

RESUMO

OBJECTIVE: The present study evaluated the early death and factors associated with early mortality in patients with glioma. METHODS: The data used for analysis in the present study was extracted from the Surveillance, Epidemiology, and End Results data set. RESULTS: A total of 58,700 patients with glioma were enrolled in the present study. The proportion of patient death within 1 month and 3 months after the diagnosis was 9.24% and 19.15% for all patients, respectively. The factors significantly associated with death within 1 month after tumor resection on multivariate analysis included age at diagnosis, year of diagnosis, tumor location, histological features, tumor size, and the absence of gross total resection, radiotherapy, and chemotherapy. We also observed similar findings in the evaluation of the factors associated with 3-month mortality. CONCLUSION: The early deaths rates, including 1 and 3 months after tumor resection in patients with glioma, have decreased slightly during the previous 40 years. The risk factors for early mortality included advanced age, male sex, tumor located in the lateral ventricle, cerebellum, or brainstem, receipt of biopsy only, no chemotherapy or radiotherapy, and specific histopathological types.

6.
Sci Total Environ ; 713: 136387, 2020 Jan 02.
Artigo em Inglês | MEDLINE | ID: mdl-31954247

RESUMO

Plastic particles recently are reported to be ubiquitous in natural environments, while biochar is widely employed as an amendment into natural environments e.g. soil for pollution remediation. It is highly likely their transport behaviors in porous media would be altered due to interaction with each other. In this study, the cotransport and deposition behaviors of biochar and plastic particles (0.02 µm nanoplastics (NPs), 0.2 µm and 2 µm micrometer-plastics (MPs)) in quartz sand were investigated at both low (5 mM) and high ionic strength (25 mM) in NaCl solutions at pH 6. The results demonstrated that smaller sized plastic particles (0.02 µm NPs and 0.2 µm MPs) increased biochar transport under both 5 and 25 mM NaCl solutions, while large plastic particles (2 µm MPs) increased biochar transport in 5 mM NaCl solutions yet decreased biochar transport in 25 mM NaCl solutions. For all sized plastic particles, biochar significantly decreased their transport at both low (5 mM) and high (25 mM) ionic strengths in NaCl solutions. The change of zeta potentials of biochar due to heteroaggregation with plastic particles, and the steric repulsion induced by the suspended plastic particles contributed to the enhanced biochar transport with the copresence of smaller sized plastic particles (0.02 µm NPs and 0.2 µm MPs). While, the cotransport of biochar with 2 µm MPs due to their heteroaggregation contributed to the varied transport behaviors of biochar observed at low and high ionic strength with the copresence of 2 µm MPs. The formation of plastic particles-biochar heteroaggregates drove to the decreased transport of all three different sized plastic particles with the copresence of biochar. Considering the coexistence of biochar and plastic particles in natural environment, they would interact with each other (form heteroaggregates) and thus lead to the change of transport behaviors in porous media.

7.
Head Neck ; 42(2): 289-301, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31710172

RESUMO

BACKGROUND: Proton radiotherapy (PRT) may be a less toxic alternative to photon radiotherapy (XRT) for patients with head and neck squamous cell carcinoma (HNSCC). However, the molecular responses of HNSCC cells to PRT vs XRT are unclear. METHODS: Proteomics analyses of protein expression profiles by reverse-phase protein arrays were done for two human papillomavirus [HPV]-negative and two HPV+ cell lines. Expression patterns of 175 proteins involved in several signaling pathways were tested. RESULTS: Compared with PRT, XRT tended to induce lower expression of DNA damage repair-and cell cycle arrest-related proteins and higher expression of cell survival- and proliferation-related proteins. CONCLUSIONS: Under these experimental conditions, PRT and XRT induced different protein expression and activation profiles. Further preclinical verification is needed, as are studies of tumor pathway mutations as biomarkers for choice of treatment or as radiosensitization targets to improve the response of HNSCC to PRT or XRT.

8.
Chemosphere ; 238: 124539, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31470310

RESUMO

The performance and microbial community structure of anaerobic dynamic membrane bioreactor (AnDMBR) treating textile wastewater was investigated. The reactor showed excellent soluble COD and color removal of 98.5% and >97.5%, respectively. Dynamic membrane layer grown over the 3D printed dynamic membrane support showed decent rejection for high molecular weight compounds (>20 kDa); and the total suspended solid rejection by the dynamic layer was >98.8%. Gel permeation chromatography analysis of extracellular polymeric substance (EPS) and effluent samples revealed EPS accounted for more than 76.7% of low molecular weight fractions (<20 kDa) that end up in the effluent. Higher applied flux facilitated the rapid formation dynamic layer which enabled a satisfactory effluent quality. Microbial community analysis revealed that during the operation the archaeal community was relatively stable while obvious changes took place in the bacterial community. Introduction of dye Remazol Brilliant Blue R (RBBR) to the AnDMBR increased the abundances of phyla of Proteobacteria and Spirochaetae whereas fractions of Firmicutes and Euryarchaeota decreased obviously. Furthermore, relative stable abundances of phyla Aminicenantes, Bacteroidetes, Thermotogae and Chloroflexi among the top six phyla detected in the system ensured a healthy anaerobic degradation environment for RBBR wastewater treatment.


Assuntos
Antraquinonas/isolamento & purificação , Antraquinonas/metabolismo , Reatores Biológicos/microbiologia , Membranas Artificiais , Têxteis , Águas Residuárias/química , Anaerobiose , Corantes/isolamento & purificação , Corantes/metabolismo , Matriz Extracelular de Substâncias Poliméricas/microbiologia , Proteobactérias/metabolismo , Spirochaeta/metabolismo , Poluentes Químicos da Água/isolamento & purificação , Poluentes Químicos da Água/metabolismo
9.
Nat Genet ; 51(11): 1637-1644, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31676860

RESUMO

Volumetric variations of the human brain are heritable and are associated with many brain-related complex traits. Here we performed genome-wide association studies (GWAS) of 101 brain volumetric phenotypes using the UK Biobank sample including 19,629 participants. GWAS identified 365 independent genetic variants exceeding a significance threshold of 4.9 × 10-10, adjusted for testing multiple phenotypes. A gene-based association study found 157 associated genes (124 new), and functional gene mapping analysis linked 146 additional genes. Many of the discovered genetic variants and genes have previously been implicated in cognitive and mental health traits. Through genome-wide polygenic-risk-score prediction, more than 6% of the phenotypic variance (P = 3.13 × 10-24) in four other independent studies could be explained by the UK Biobank GWAS results. In conclusion, our study identifies many new genetic associations at the variant, locus and gene levels and advances our understanding of the pleiotropy and genetic co-architecture between brain volumes and other traits.


Assuntos
Encéfalo/anatomia & histologia , Transtornos Cognitivos/genética , Marcadores Genéticos , Estudo de Associação Genômica Ampla , Transtornos Mentais/genética , Polimorfismo de Nucleotídeo Único , Característica Quantitativa Herdável , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Encéfalo/metabolismo , Criança , Pré-Escolar , Transtornos Cognitivos/patologia , Estudos de Coortes , Feminino , Estudos de Associação Genética , Predisposição Genética para Doença , Humanos , Desequilíbrio de Ligação , Masculino , Transtornos Mentais/patologia , Saúde Mental , Pessoa de Meia-Idade , Herança Multifatorial , Fenótipo , Reino Unido , Adulto Jovem
10.
Mol Psychiatry ; 2019 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-31666681

RESUMO

Individual variations of white matter (WM) tracts are known to be associated with various cognitive and neuropsychiatric traits. Diffusion tensor imaging (DTI) and genome-wide single-nucleotide polymorphism (SNP) data from 17,706 UK Biobank participants offer the opportunity to identify novel genetic variants of WM tracts and explore the genetic overlap with other brain-related complex traits. We analyzed the genetic architecture of 110 tract-based DTI parameters, carried out genome-wide association studies (GWAS), and performed post-GWAS analyses, including association lookups, gene-based association analysis, functional gene mapping, and genetic correlation estimation. We found that DTI parameters are substantially heritable for all WM tracts (mean heritability 48.7%). We observed a highly polygenic architecture of genetic influence across the genome (p value = 1.67 × 10-05) as well as the enrichment of genetic effects for active SNPs annotated by central nervous system cells (p value = 8.95 × 10-12). GWAS identified 213 independent significant SNPs associated with 90 DTI parameters (696 SNP-level and 205 locus-level associations; p value < 4.5 × 10-10, adjusted for testing multiple phenotypes). Gene-based association study prioritized 112 significant genes, most of which are novel. More importantly, association lookups found that many of the novel SNPs and genes of DTI parameters have previously been implicated with cognitive and mental health traits. In conclusion, the present study identifies many new genetic variants at SNP, locus and gene levels for integrity of brain WM tracts and provides the overview of pleiotropy with cognitive and mental health traits.

11.
Molecules ; 24(22)2019 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-31703405

RESUMO

A simple, sensitive and effective magnetic solid-phase extraction (MSPE) technique was developed for the extraction of pyrethroid pesticides from environmental water samples, followed by gas chromatography tandem triple quadrupole mass spectrometry determination. An adsorbent of magnetic zeolitic imidazolate framework-8@deep eutectic solvent (M-ZIF-8@DES) was prepared using deep eutectic solvent coated on the surface of M-ZIF-8. The features of M-ZIF-8@DES were confirmed by material characterizations, and the results indicated that M-ZIF-8@DES has a good magnetism (61.3 emu g-1), a decent surface area (96.83 m2 g-1) and pore volume (0.292 mL g-1). Single factor experiments were carried out to investigate the effect of different conditions on the performance of MSPE. Under the optimal conditions, the developed method performs good linearity (R2 ≥ 0.9916) in the concentration range of 1-500 µg L-1. The limits of detection were in the range of 0.05-0.21 µg L-1 (signal/noise = 3/1). The intraday relative standard deviation (RSD) and interday RSD were less than 9.40%. Finally, the proposed technique was applied for the determination of pyrethroid pesticides in environmental water samples. This work shows the potential of DES-modified metal-organic frameworks for different sample pretreatment techniques.

12.
Nano Lett ; 19(11): 7941-7949, 2019 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-31658417

RESUMO

Two-dimensional layered materials (2DLMs) have been extensively studied in a variety of planar optoelectronic devices. Three-dimensional (3D) optoelectronic structures offer unique advantages including omnidirectional responses, multipolar detection, and enhanced light-matter interactions. However, there has been limited success in transforming monolayer 2DLMs into reconfigurable 3D optoelectronic devices due to challenges in microfabrication and integration of these materials in truly 3D geometries. Here, we report an origami-inspired self-folding approach to reversibly transform monolayer molybdenum disulfide (MoS2) into functional 3D optoelectronic devices. We pattern and integrate monolayer MoS2 and gold (Au) onto differentially photo-cross-linked thin polymer (SU8) films. The devices reversibly self-fold due to swelling gradients in the SU8 films upon solvent exchange. We fabricate a wide variety of optically active 3D MoS2 microstructures including pyramids, cubes, flowers, dodecahedra, and Miura-oris, and we simulate the self-folding mechanism using a coarse-grained mechanics model. Using finite-difference time-domain (FDTD) simulation and optoelectronic characterization, we demonstrate that the 3D self-folded MoS2 structures show enhanced light interaction and are capable of angle-resolved photodetection. Importantly, the structures are also reversibly reconfigurable upon solvent exchange with high tunability in the optical detection area. Our approach provides a versatile strategy to reversibly configure 2D materials in 3D optoelectronic devices of broad relevance to flexible and wearable electronics, biosensing, and robotics.

13.
Small ; 15(47): e1903977, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31608586

RESUMO

Black phosphorous quantum dots (BPQDs) possess ambipolar charge transport, high mobility, and a tunable direct bandgap. Here, liquid-exfoliated BPQDs are used as interlayers to modify both the electron transport layer and hole transport layer in organic solar cells (OSCs). The incorporation of BPQDs is beneficial to the formation of a cascade band structure and electron/hole transfer and extraction. The power conversion efficiency of the BPQDs-incorporated OSC based on PTB7-Th:FOIC blend is enhanced from 11.8% to 13.1%. In addition, power conversion efficiency enhancement is also achieved for other nonfullerene and fullerene-based devices, demonstrating the universality of this interlayer methodology.

14.
Environ Pollut ; 255(Pt 2): 113300, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31610513

RESUMO

Microplastics (MPs) can disintegrate into smaller sized microplastics and even nanoplastics (NPs). The toxicity of nanoplastics and microplastics on freshwater organisms have been well explored recently, however, very little is known about the potential impacts of NPs on freshwater biofilms, which are essential for primary production and nutrient cycling in aquatic ecosystems. In this study, we studied the acute effects (3 h of exposure) of polystyrene beads (PS, with diameter range from 100 nm to 9 µm) on five biological endpoints targeting community and ecosystem-level processes in biofilms: chlorophyll a, photosynthetic yield, and three extracellular enzyme activities. The results showed that the large size PS beads (500 nm, 1 µm, and 9 µm) exhibited negligible effects on the determined biological endpoints in biofilms within the range of concentrations (5-100 mg/L) in this study. However, high concentration of PS beads (100 nm, 100 mg/L) significantly decreased the content of chlorophyll a, and the functional enzyme activities of ß-glucosidase and leucine aminopeptidase, suggesting negative effects on the carbon and nitrogen cycling of freshwater biofilms. Moreover, the influences of PS NPs (100 nm) on biofilms strongly depended on the surface modification of PS particles, with the positively charged PS NPs (amide-modified) exhibiting the highest toxicity to biofilms. The excess generation of reactive oxygen species (ROS) in this study indicated oxidative stress induced by PS NPs, which might lead to the observed nano-toxic effects on biofilms. In response, the antioxidant activity of biofilm was enhanced as indicated by the increased total antioxidant capacity (T-AOC). Overall, our findings highlight nanoplastics have potential to disrupt the basic ecological functions of biofilms in aquatic environments.

15.
Chemistry ; 2019 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-31605403

RESUMO

A new ternary composite of 1T-molybdenum disulfide, hexagonal tungsten trioxide, and reduced graphene oxide (M-W-rGO) is synthesized by using a one-pot hydrothermal process. The synergetic effect of 1T-MoS2 and hexa-WO3 nanoflowers improves the electrochemical performance for supercapacitors by inducing additional active sites and hexagonal tunnels, respectively, which lead to high storage capacity and easy transfer of electrolyte ions. The ternary M-W-rGO composite has a high specific capacitance of 836 F g-1 at 1 A g-1 , which is nearly twice that of binary composites of M-rGO and W-rGO with high capacitance retention of 86.35 % after 3000 cycles at a high current density of 5 A g-1 . This study provides a new ternary composite that can be used as an electrode material for high-performance supercapacitors.

16.
Biometrics ; 2019 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-31544963

RESUMO

Although case-control association studies have been widely used, they are insufficient for many complex diseases, such as Alzheimer's disease and breast cancer, since these diseases may have multiple subtypes with distinct morphologies and clinical implications. Many multigroup studies, such as the Alzheimer's Disease Neuroimaging Initiative (ADNI), have been undertaken by recruiting subjects based on their multiclass primary disease status, while extensive secondary outcomes have been collected. The aim of this paper is to develop a general regression framework for the analysis of secondary phenotypes collected in multigroup association studies. Our regression framework is built on a conditional model for the secondary outcome given the multigroup status and covariates and its relationship with the population regression of interest of the secondary outcome given the covariates. Then, we develop generalized estimation equations to estimate the parameters of interest. We use both simulations and a large-scale imaging genetic data analysis from the ADNI to evaluate the effect of the multigroup sampling scheme on standard genome-wide association analyses based on linear regression methods, while comparing it with our statistical methods that appropriately adjust for the multigroup sampling scheme. Data used in preparation of this article were obtained from the ADNI database.

17.
Proc Conf AAAI Artif Intell ; 33: 5765-5772, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31485381

RESUMO

We consider the problem of performing an association test between functional data and scalar variables in a varying coefficient model setting. We propose a functional projection regression model and an associated global test statistic to aggregate relatively weak signals across the domain of functional data, while reducing the dimension. An optimal functional projection direction is selected to maximize signal-to-noise ratio with ridge penalty. Theoretically, we systematically study the asymptotic distribution of the global test statistic and provide a strategy to adaptively select the optimal tuning parameter. We use simulations to show that the proposed test outperforms all existing state-of-the-art methods in functional statistical inference. Finally, we apply the proposed testing method to the genome-wide association analysis of imaging genetic data in UK Biobank dataset.

18.
ACS Appl Mater Interfaces ; 11(36): 33006-33011, 2019 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-31414589

RESUMO

A new fused-chrysene electron-donating core is synthesized, where chrysene is condensed with two thiophenes via two dihydrobenzene rings. Based on this building block coupled with two electron-accepting end groups of 1,1-dicyanomethylene-3-indanone, a new Z-shaped fused-ring electron acceptor, FCIC, is designed and synthesized. FCIC shows intense absorption in the 500-850 nm region, with a maximum molar absorptivity of 1.5 × 105 M-1 cm-1, a bandgap of 1.50 eV, and a charge mobility of 2.5 × 10-4 cm2 V-1 s-1. The ternary organic photovoltaic cells based on PTB7-Th/F8IC/FCIC yield an efficiency of 12.6%, higher than that of the binary cells of PTB7-Th/F8IC (10.7%) and PTB7-Th/FCIC (7.21%). Relative to the PTB7-Th/F8IC binary blend, the addition of FCIC leads to improvement in the open-circuit voltage, short-circuit current, and fill factor.

19.
J BUON ; 24(3): 1087-1091, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31424665

RESUMO

PURPOSE: To study the clinical effect of endoscopic mucosal resection (EMR) in the treatment of early gastric cancer (EGC), and to evaluate the recovery and prognosis, so as to provide references for clinical selection of treatment methods. METHODS: 120 patients with EGC were selected and randomly divided into the EMR group and the radical surgery group. Before surgery and 3 days after surgery, the levels of traumatic response-related indexes in serum [adrenocorticotropic hormone (ACTH), cortisol (Cor), gastrin (GAS) and motilin (MTL)] were assessed. Before surgery, 3 months and 1 year after surgery, the expression levels of tumor markers [carcinoembryonic antigen (CEA), carbohydrate antigen 19.9 (CA19.9), CA125 and CA724] were assessed. Before surgery and 3 days and 3 months after surgery, the immune function indexes [cluster of differentiation (CD)25+, CD28+ and inducible costimulator (ICOS)] were measured. Moreover, the clinical effect of surgery and the incidence rate of complications were compared between the two groups, and patients were followed up for at least 2 years to evaluate their prognosis. RESULTS: The clinical cure rate of tumor resection was comparable in both groups, and the incidence rate of complications in the EMR group was significantly lower than that in the radical surgery group (p<0.05). The levels of tumor markers were significantly increased compared with those before surgery in both groups (p<0.05), but without significant differences between the two groups. Three days after surgery in the radical surgery group, ACTH and Cor were increased, while GAS and MTL were decreased, and the levels of immune indexes declined (p<0.05). In the EMR group, the above indexes had no significant differences compared with those before surgery. Three days after surgery, the survival and recurrence rate in the EMR group and the radical surgery group were 95.0% vs. 98.3% and 5.0% vs. 3.3%, respectively (p>0.05). CONCLUSIONS: The treatment of EGC with EMR has comparable clinical effect and prognosis to the traditional radical surgery, which causes less damage to the body and gastrointestinal function and less inhibition on the immune function, so it is worthy of clinical application.

20.
Proc Natl Acad Sci U S A ; 116(32): 15855-15860, 2019 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-31332010

RESUMO

During the first 2 postnatal years, cortical thickness of the human brain develops dynamically and spatially heterogeneously and likely peaks between 1 and 2 y of age. The striking development renders this period critical for later cognitive outcomes and vulnerable to early neurodevelopmental disorders. However, due to the difficulties in longitudinal infant brain MRI acquisition and processing, our knowledge still remains limited on the dynamic changes, peak age, and spatial heterogeneities of cortical thickness during infancy. To fill this knowledge gap, in this study, we discover the developmental regionalization of cortical thickness, i.e., developmentally distinct regions, each of which is composed of a set of codeveloping cortical vertices, for better understanding of the spatiotemporal heterogeneities of cortical thickness development. We leverage an infant-dedicated computational pipeline, an advanced multivariate analysis method (i.e., nonnegative matrix factorization), and a densely sampled longitudinal dataset with 210 serial MRI scans from 43 healthy infants, with each infant being scheduled to have 7 longitudinal scans at around 1, 3, 6, 9, 12, 18, and 24 mo of age. Our results suggest that, during the first 2 y, the whole-brain average cortical thickness increases rapidly and reaches a plateau at about 14 mo of age and then decreases at a slow pace thereafter. More importantly, each discovered region is structurally and functionally meaningful and exhibits a distinctive developmental pattern, with several regions peaking at varied ages while others keep increasing in the first 2 postnatal years. Our findings provide valuable references and insights for early brain development.

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