Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 42
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Chemosphere ; 282: 131110, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34470162

RESUMO

Fibrous activated carbon has attracted emerging research interests due to its remarkable adsorption performance for volatile organic compounds (VOCs). Though this adsorption behavior for VOCs is closely related to the pore structure on the surface of activated carbon fiber (ACF), few researchers paid attentions to the influence of textural properties of this adsorption process. Especially, cotton-based activated carbon fiber (CACF) for adsorbing benzene pollutant is rarely reported. Herein, in order to develop a high-performance adsorbent for the removal of VOCs pollutants, this work studied the influence of textural properties of CACF on the adsorption of benzene. The results showed that the increase of carbonization temperature would lead to the reduction of mesopores but the increase of micropores for CACF; the embedment of phosphoric acid and its derivatives into the carbon layers contributed to the formation of pore structure for CACF; furthermore, specific surface area of CACF can also be enlarged by increasing the concentration of phosphoric acid. More importantly, it was found that the adsorption capacity of CACF for benzene was strongly dependent on the specific surface area and volume of micropores within CACF because micropores can provide more favorable binding sites. This adsorption process preferred to occur on the wall of micropores, then the accumulated benzene would slowly fill the pores. Interestingly, the decrease of pore size of micropores can unexpectedly improve the affinity of CACF to benzene on the contrary. This work provides a new strategy to develop porous structured ACF materials for the high-performance adsorption of VOCs.


Assuntos
Benzeno , Carvão Vegetal , Adsorção , Fibra de Carbono , Porosidade
2.
Nanotechnology ; 32(50)2021 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-34584021

RESUMO

Herein, we report an enhanced red emission from colloidal silicon nanocrystals (c-Si NCs) solution-processed light-emitting diode. c-Si NCs were synthesized by facile femtosecond laser ablation. Based on the structural characterization and opto-electrics properties analysis, both photoluminescence and electroluminescence arise from the radiative recombination of carriers due to quantum confined effect. The optical power density and highest external quantum efficiency have been obtained to be 0.79 mW cm-2and âˆ¼6.6%, respectively. These results indicate that Si NCs are very attractive as a potential optical source for future integrated chips.

3.
Artigo em Inglês | MEDLINE | ID: mdl-34014080

RESUMO

In this work, several carbon-decorated Na3V2(PO4)3 materials (NVP@C-750/800/850) are successfully fabricated using a sol-gel approach and subsequent heat treatment. When NVP@C-800 is used as a cathode, it shows an ultralong cycle life (2000 cycles) at a high rate of 10C, which is superior to the other two electrodes and those of reported NVP@C cathodes in the literature. The excellent results of NVP@C-800 are attributed to its nanostructure and the well-defined conductive carbon layer. The symmetric sodium (Na)-ion battery (SIB) with NVP@C-800 as both a cathode and an anode shows a high capacity at 40 mA g-1 with a voltage plateau of about 1.79 V and energy density of 113 W h kg-1, revealing that NVP@C is of great application prospect.

4.
Mol Med Rep ; 23(6)2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33880584

RESUMO

Acute lung injury (ALI) is a serious clinical problem. The present study was performed to investigate the effect of structured triglyceride (STG) on the development of lipopolysaccharide (LPS)­induced ALI and its underlying mechanism of action. To establish an LPS­induced ALI mouse model, mice were intranasally administered 50 µl LPS. The pathological changes in the lung were observed via haematoxylin­eosin staining. The lung injury score, lung wet/dry weight (W/D) ratio, and myeloperoxidase (MPO) activity were used to evaluate the degree of lung injury. The expression levels of interleukin (IL)­1ß, IL­6 and tumour necrosis factor­α in lung tissues were measured through reverse transcription­quantitative polymerase chain reaction. The enzyme­linked immunosorbent assay was used to measure the levels of pro­inflammatory cytokines in bronchoalveolar lavage fluid. Furthermore, western blotting was performed to detect the activity of the transforming growth factor­α­activated kinase 1 (TAK1)/NF­κB pathway. LPS­induced ALI mice were treated with AH7614 [a G­protein coupled receptor 120 (GPR120) inhibitor] to confirm the effect of STG on GPR120. STG treatment decreased the lung pathological changes, lung injury score, lung W/D ratio, and proinflammatory cytokine expression levels and inhibited TAK1/NF­κB pathway activity in the LPS­induced ALI mouse model. Additionally, AH7614 reversed the inhibitory effects of STG on lung injury, inflammation, and TAK1/NF­κB pathway activity in ALI. Moreover, AH7614 weakened the inhibitory effects of STG on inflammation and TAK1/NF­κB pathway activity in LPS­induced RAW264.7 cells. Collectively, STG may suppress the TAK1/NF­κB pathway activity by enhancing GPR120 expression to alleviate the lung injury and inflammation in ALI. These results suggest the therapeutic potential of STG in the treatment of ALI.


Assuntos
Inflamação/metabolismo , Lipopolissacarídeos/efeitos adversos , Lesão Pulmonar/metabolismo , Receptores Acoplados a Proteínas G/metabolismo , Triglicerídeos/metabolismo , Lesão Pulmonar Aguda/patologia , Animais , Líquido da Lavagem Broncoalveolar , Citocinas/metabolismo , Interleucina-1beta , Interleucina-6 , Pulmão/patologia , Lesão Pulmonar/induzido quimicamente , MAP Quinase Quinase Quinases/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , NF-kappa B/metabolismo , Células RAW 264.7 , Receptores Acoplados a Proteínas G/genética , Sulfonamidas , Fator de Necrose Tumoral alfa , Xantenos
5.
Nanotechnology ; 32(30)2021 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-33878745

RESUMO

Polypyrrole (PPy) has high electrochemical activity and low cost, so it has great application prospects in wearable supercapacitors. Herein, we have successfully prepared polypyrrole/reduced graphene oxide (PPy/rGO) nanocomposite cotton fabric (NCF) by chemical polymerization, which exhibits splendid electrochemical performance compared with the individual. The addition of rGO can block the deformation of PPy caused by the expansion and contraction. The as-prepared PPy-0.5/rGO NCF electrode exhibits the brilliant specific capacitance (9300 mF cm-2at 1 mA cm-2) and the capacitance retention with 94.47% after 10 000 cycles. At the same time, the superior capacitance stability under different bending conditions and reuse capability have been achieved. All-solid-state supercapacitor has high energy density of 167µWh cm-2with a power density of 1.20 mW cm-2. Therefore, the PPy-0.5/rGO NCF electrode has a broad application prospect in high-performance flexible supercapacitor fabric electrode.

7.
Chem Commun (Camb) ; 2021 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-33543182

RESUMO

CoMn phosphide encapsulated in a nitrogen-doped graphene core-shell structure was successfully prepared with Prussian Blue complexes as the precursor and P atom doping at a high temperature. The core-shell heterostructure demonstrates an impressive catalytic performance of hydrogen evolution reaction over a broad pH range, i.e., the overpotentials reach 159, 190 and 279 mV at a current density of 20 mA cm-2 in the conditions of pH = 0, 14 and 7, and maintains excellent stability.

8.
Medicine (Baltimore) ; 100(4): e23891, 2021 Jan 29.
Artigo em Inglês | MEDLINE | ID: mdl-33530184

RESUMO

BACKGROUND: Electroacupuncture is increasingly used in rehabilitation for postoperative cognitive dysfunction (POCD), but relevant evidence remains unclear for patients receiving total knee arthroplasty (TKA). METHODS: The databases research of PubMed, EMBASE, CINAHL, and China National Knowledge Infrastructure (CNKI) will be conducted from inception to December 31, 2020. The relevant randomized controlled trials (RCTs) from data will be screened one by one. The remaining studies that meet the inclusion criteria will be extracted and analyzed using RevMan V.5.3 software. Paired 2 reviewers will assess quality of the included studies and publication bias by using the Cochrane Collaboration risk of bias tool, and Egger test and Begg test respectively. And grading of recommendations assessment, development and evaluation (GRADE) will be used to estimate the quality of evidence. RESULTS: In this study, we will analyze the effect of electroacupuncture on Mini-Mental State Examination (MMSE), interleukin 1ß (IL-1ß), tumor necrosis factor-α (TNF-α), S100-ß protein, and adverse events for patients with TKA. CONCLUSION: Our findings will provide evidence for the effectiveness of electroacupuncture on the treatment and prevention of POCD for TKA patients. REGISTRATION NUMBER: Available at: https://osf.io/azyt9 (DOI number: 10.17605/OSF.IO/AZYT9).


Assuntos
Artroplastia do Joelho/efeitos adversos , Eletroacupuntura , Metanálise como Assunto , Complicações Cognitivas Pós-Operatórias/terapia , Revisões Sistemáticas como Assunto , Protocolos Clínicos , Humanos , Complicações Cognitivas Pós-Operatórias/prevenção & controle , Ensaios Clínicos Controlados Aleatórios como Assunto , Projetos de Pesquisa
9.
Nanotechnology ; 2021 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-33494075

RESUMO

Heteroatom-doped carbon materials with a high specific area, a well-defined porous structure is important to high-performance supercapacitors (SCs). Here, S and N co-doped three-dimensional porous graphene aerogel (NS-3DPGHs) have been synthesized in a facile and efficient self-assembly process with thiourea acting as the reducing and doping agent solution. Operating as a SC electrode, fabricated co-doping graphene, i.e., the sample of NS-3DPGH-150 exhibits the highest specific capacitance of 412.9 F g-1 under 0.5 A g-1 and prominent cycle stabilization with 96.4% capacitance retention in the back of 10000 cycles. Furthermore, based on NS-3DPGH-150, the symmetrical supercapacitor as-prepared in 6 M KOH displays a superior energy density of 12.9 Wh kg-1 under the power density of 249 W kg-1. Hence, NS-3DPGHs could be considered as an excellent candidate for SCs.

10.
Polymers (Basel) ; 12(10)2020 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-32998274

RESUMO

A new kind of bifunctional microcapsule containing a n-octadecane (OD) and thyme oil (TO) core based on polyurea shell designed for thermal energy storage and antibiosis was prepared successfully through interfacial polymerization. The scanning electron microscopic investigations reveal that the obtained composite microcapsules present the regular spherical morphology and the transmission electron microscopic observations confirm the clear core-shell structure. Morphological and chemical structure analyses prove the successful synthesis of bifunctional microcapsules. Thermogravimetric analysis indicates that the polyurea shell can protect the composite cores effectively. Differential scanning calorimetry examination shows that the bifunctional microcapsules can maintain high thermal storage capacity and the encapsulation efficiency of OD increases with the increase in TO. The supercooling crystallization can be notably suppressed by adding 7 wt.% of n-octadecanol. A study on the release behavior of TO from the bifunctional microcapsules reveals that the Higuchi kinetic model could better fit the TO release profile. The antibacterial results demonstrate that the bifunctional microcapsules can effectively inhibit the growth of Staphylococcus aureus and the inhibition rate can reach as high as 99.9% when the mass concentration of microcapsules is over 3 wt.%.

11.
Nanoscale ; 12(40): 20638-20648, 2020 Oct 22.
Artigo em Inglês | MEDLINE | ID: mdl-32657312

RESUMO

There is a growing need for fast, efficient, safe, and low-cost energy storage. Aqueous zinc-ion batteries (AZIBs) may be able to address this need, but suffer from fast capacity fade and poor ion diffusion kinetics due to unstable structures and non-optimised interspacing of layered cathode materials. Herein, we propose a structural engineering strategy by synergistically inducing anionic defects and cationic groups within vanadium bronze structures to improve kinetics and boost capacity. The materials discovered and used as the cathodes in AZIBs showed a high capacity of 435 mA h g-1 at a current density of 0.2 A g-1 and excellent stability with 95% capacity retention after 1500 cycles at 10 A g-1. This combined experimental and computational study systemically indicated that rapid Zn2+ storage was achieved from both a highly porous structure and enlarged d-spacing combined with improved electron conductivity as determined by density of states calculations. The modification of vanadium bronze-type cathodes achieved by controlled pre-intercalated species and tailored oxygen deficiency opens up an avenue for the realization of superior material design, whose feasibility is proved in this work.

12.
Adv Sci (Weinh) ; 7(12): 1903674, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32596112

RESUMO

The hydrogen evolution reaction (HER) is a critical process in the electrolysis of water. Recently, much effort has been dedicated to developing low-cost, highly efficient, and stable electrocatalysts. Transition metal phosphides are investigated intensively due to their high electronic conductivity and optimized absorption energy of intermediates in acid electrolytes. However, the low stability of metal phosphide materials in air and during electrocatalytic processes causes a decay of performance and hinders the discovery of specific active sites. The HER in alkaline media is more intricate, which requires further delicate design due to the Volmer steps. In this work, phosphorus-modified monoclinic ß-CoMoO4 is developed as a low-cost, efficient, and stable HER electrocatalyst for the electrolysis of water in alkaline media. The optimized catalyst shows a small overpotential of 94 mV to reach a current density of 10 mA cm-2 for the HER with high stability in KOH electrolyte, and an overpotential of 197 mV to reach a current density of 100 mA cm-2. Combined computational and in situ spectroscopic techniques show P is present as a surface phosphate ion; that electron holes localize on the surface ions and both (P-O1-) and Co3+-OH- are prospective surface active sites for the HER.

13.
Eur J Clin Microbiol Infect Dis ; 39(9): 1771-1779, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32242313

RESUMO

Pentamidine sensitizes FDA-approved antibiotics to combat Gram-negative pathogens. We screened 1374 FDA-approved non-antibiotics for their ability to be sensitized by pentamidine against Escherichia coli. We identified mitomycin C and mefloquine as potent hits effective against multiple drug-resistant, Gram-negative bacteria. Killing kinetics and an in vivo model with Caenorhabditis elegans (C. elegans) revealed that such combinations produced synergy against colistin-resistant Enterobacter cloacae (E. cloacae). These findings suggest combinations of FDA-approved non-antibiotics, and pentamidine can be repurposed into new antimicrobial agents.


Assuntos
Antibacterianos/farmacologia , Bactérias Gram-Negativas/efeitos dos fármacos , Infecções por Bactérias Gram-Negativas/tratamento farmacológico , Pentamidina/farmacologia , Animais , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Caenorhabditis elegans/efeitos dos fármacos , Reposicionamento de Medicamentos , Farmacorresistência Bacteriana Múltipla , Sinergismo Farmacológico , Quimioterapia Combinada , Enterobacter cloacae/efeitos dos fármacos , Infecções por Bactérias Gram-Negativas/microbiologia , Humanos , Testes de Sensibilidade Microbiana , Modelos Animais , Pentamidina/administração & dosagem , Pentamidina/uso terapêutico , Estados Unidos , United States Food and Drug Administration
14.
Drug Des Devel Ther ; 14: 1333-1339, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32308366

RESUMO

Background: Carbon monoxide (CO) poisoning is a common health problem among people in many countries, primarily because of its severe clinical effects and high toxicological morbidity and mortality. Acute brain injury and delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) are the most common neurological complications. This study was performed to assess the efficacy of N-butylphthalide (NBP) and dexamethasone (DXM) combined with hyperbaric oxygen (HBO) in patients with DEACMP. Patients and Methods: A total of 171 patients with DEACMP were recruited and assigned to the combined therapy group (receiving NBP and DXM 5 mg/day plus HBO therapy) or the control group (HBO therapy as monotherapy). Conventional treatments were provided for all patients. The cognition and movement changes in patients were evaluated by the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA) scale and the Barthel index of activities of daily living (ADL) before and after the treatment at 1 month, 3 months, and 1 year, respectively. Results: At 1 month, 3 months, and 1 year after the treatment, the MMSE, MoCA and ADL scores were all significantly higher in the combined therapy group than those in the control group. There were no significant alterations in blood glucose, blood lipids, or liver and kidney function during the whole treatment session. Some patients experienced loss of appetite, mild headache and minor skin irritations. However, these patients recovered by themselves and needed no additional medications or special treatment. Conclusion: These results indicated that NBP and DXM combined with HBO for the treatment of DEACMP can significantly improve the cognitive and motor functions of patients and is very safe.


Assuntos
Atividades Cotidianas , Benzofuranos/uso terapêutico , Encefalopatias/etiologia , Intoxicação por Monóxido de Carbono/complicações , Intoxicação por Monóxido de Carbono/terapia , Dexametasona/uso terapêutico , Oxigenação Hiperbárica , Doença Aguda , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Benzofuranos/administração & dosagem , Encefalopatias/patologia , Encefalopatias/prevenção & controle , Intoxicação por Monóxido de Carbono/patologia , Terapia Combinada , Dexametasona/administração & dosagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
15.
Polymers (Basel) ; 12(2)2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-32024144

RESUMO

Reactive dyes containing cationic groups have great potentiality as novel dyes, which can be applicable to one-bath dyeing of wool/acrylic blended fabrics. In this work, four novel heterocyclic reactive dyes containing cationic groups were designed by using m-aminophenyltrimethylammonium salt or N-(2-aminoethyl) pyridinium chloride salt as cationic groups, N, N-diethyl-1,3-benzenediamine as a coupling component, 2-amino-6-methoxybenzothiazole, 2-aminobenzothiazole or 3-amino-5-nitrobenzoisothiazole as diazo components. These dyes based on benzothiazole derivative chromophores not only showed beautiful color, including blue-green and fuchsia, but also had larger tinctorial strength with a high molar extinction coefficient, further reducing the dosage of dyes to achieve same color depth. Factors affecting the dyeability on fabrics, such as pH value, dyeing temperature and dye concentration were discussed. Excellent dyeing behavior, levelling properties and good fastness on wool/acrylic blended fabric were obtained. What' more, excellent anti-ultraviolet and antibacterial properties were obtained for textiles with these dyes. The application of these dyes with large molar extinction coefficients presents a wide range of possibilities for the further development of cleaner production and eco-friendly dyeing, even functional textiles.

16.
Front Chem ; 7: 595, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31552217

RESUMO

Binary metal oxides composed of molybdenum-vanadium oxides are promising candidates for supercapacitors. Here, we report the synthesis of one-dimensional V0.13Mo0.87O2.935 nanowires through a facile one-step hydrothermal method. This nanowire presented a high specific capacitance of 394.6 F g-1 (1 mV s-1) as an electrode applied to the supercapacitor. Importantly, this electrode showed a perfect rate capability of 91.5% (2 to 10 A g-1) and a continuous verified outstanding cyclic voltammetry of 97.6% after 10,000 cycles. These superior electrochemical properties make the synthesized V0.13Mo0.87O2.935 nanowires a prospective candidate for high-performance supercapacitors.

17.
Materials (Basel) ; 12(16)2019 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-31426615

RESUMO

TiO2 is regarded as a prospective electrode material owing to its excellent electrochemical properties such as the excellent cycling stability and the high safety. However, its low capacity and low electronic conductivity greatly restrict the further improvement in electrochemical performance. A new strategy was put forward to solve the above defects involved in TiO2 in which the low capacity was enhanced by nanomerization and porosity of TiO2, and the low electronic conductivity was improved by introducing Ag with a high conductivity. One-dimensional mesoporous Ag nanoparticles-embedded TiO2 nanofibers (Ag@TiO2 nanofibers) were successfully synthesized via a one-step electrospinning process combined with subsequent annealing treatment in this study. The microstructure and morphology of mesoporous TiO2@Ag nanofibers were confirmed by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and nitrogen adsorption-desorption. TiO2 nanofibers mainly consisted of a large amount of anatase TiO2, accompanied with traces of rutile TiO2. Ag nanoparticles were uniformly distributed throughout TiO2 nanofibers and promoted the transformation of TiO2 from the anatase to the rutile. The corresponding electrochemical performances are measured by galvanostatic charge-discharge, cycle stability, rate performance, cycle voltammetry, and electrochemical impedance spectroscopy measurements in this research, with pristine TiO2 nanofibers as the reference. The results indicated that the introduction of Ag nanoparticles into TiO2 nanofibers significantly improved the diffusion coefficient of Li ions (5.42 × 10-9 cm2⋅s-1 for pristine TiO2, 1.96 × 10-8 cm2⋅s-1 for Ag@TiO2), and the electronic conductivity of TiO2 (1.69 × 10-5 S⋅cm-1 for pristine TiO2, and 1.99 × 10-5 S⋅cm-1 for Ag@TiO2), based on which the comprehensive electrochemical performance were greatly enhanced. The coulombic efficiency of the Ag@TiO2 nanofibers electrode at the first three cycles was about 56%, 93%, and 96%, which was higher than that without Ag (48%, 66%, and 79%). The Ag@TiO2 nanofibers electrode exhibited a higher specific discharge capacity of about 128.23 mAh⋅g-1 when compared with that without Ag (72.76 mAh·g-1) after 100 cycles at 100 mA·g-1. With the current density sharply increased from 40 mA·g-1 to 1000 mA·g-1, the higher average discharge capacity of 56.35 mAh·g-1 was remained in the electrode with Ag, when compared with the electrode without Ag (average discharge capacity of about 12.14 mAh·g-1). When the current density was returned to 40 mA·g-1, 80.36% of the initial value was returned (about 162.25 mAh·g-1) in the electrode with Ag, which was evidently superior to that without Ag (about 86.50 mAh·g-1, only 55.42% of the initial value). One-dimensional mesoporous Ag@TiO2 nanofibers can be regarded as a potential and promising candidate as anode materials for lithium ion batteries.

18.
J Colloid Interface Sci ; 556: 386-391, 2019 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-31470353

RESUMO

The design of multicomponent electrode materials is attractive for advanced supercapacitors due to synergistic and multifunctional effects among different active materials. We reported here a structure-designed synthesis strategy to controllably fabricate hierarchical NiCo2O4@NiO composites on carbon fiber paper. The hierarchical structure with NiCo2O4 core and NiO shell provided more active sites for ion transportation and storage to improve utilization rate of electrode materials, enhancing the specific capacitance and rate performance. As an ideal electrode material for supercapacitors, the NiCo2O4@NiO electrode exhibit high specific capacitance (1188 F/g at 2 A/g), excellent rate capability with ∼85% capacitance retained at 10 A/g, and compelling cycling performance (∼106.8% of the initial capacitance retention over 7000 cycles). The present work demonstrated a structure-designed strategy to construct high-performance multicomponent electrode materials for supercapacitors.

19.
Chem Commun (Camb) ; 55(64): 9432-9435, 2019 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-31328209

RESUMO

Humid atmospheric pressure plasma jets (APPJs) sustained in an argon/water vapour mixture were adopted to treat CoMoO4 nanosheets arrays, which resulted in micro-defects on the surface and the appearance of hydroxyl (OH-) groups absorbed on the nanosheets. Benefiting from these changes, the plasma treated CoMoO4 exhibited similar catalytic property to RuO2, an overpotential 70 mV lower than for pristine CoMoO4 and maintained good stability after 30 hours for the water oxidation.

20.
Medicine (Baltimore) ; 98(7): e14445, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30762755

RESUMO

The aim of this study was to investigate the association between purinergic receptor P2X7 (P2RX7) gene rs1718125 polymorphism and analgesic effect of fentanyl after surgery among patients with lung cancer in a Chinese Han population.A total of 238 patients with lung cancer who received resection were enrolled in our study. The genotype distributions of P2RX7 rs1718125 polymorphism were detected by polymerase chain reaction and direct sequencing. Postoperative analgesia was performed by patient-controlled intravenous analgesia, and the consumption of fentanyl was recorded. The postoperative pain was measured by visual analog scale (VAS). Differences in postoperative VAS score and postoperative fentanyl consumption for analgesia in different genotype groups were analyzed by analysis of variance assay.The frequencies of GG, GA, and AA genotypes were 46.22%, 44.96%, and 8.82%, respectively. After surgery, the postoperative VAS score of GA group was significantly high in the period of analepsia after general anesthesia and at 6 hours after surgery (P = .041 and P = .030, respectively), while AA group exhibited obviously high in the period of analepsia after general anesthesia (P < .001), at postoperative 6 hours (P = .006) and 24 hours (P = .016). Moreover, the patients carrying GA and AA genotypes needed more fentanyl to control pain within 48 hours after surgery (P < .05 for all).P2RX7 gene rs1718125 polymorphism is significantly associated with postoperative pain and fentanyl consumption in patients with lung cancer.


Assuntos
Analgésicos Opioides/uso terapêutico , Fentanila/uso terapêutico , Neoplasias Pulmonares/genética , Dor Pós-Operatória/genética , Receptores Purinérgicos P2X7/genética , Idoso , Analgesia Controlada pelo Paciente/estatística & dados numéricos , Grupo com Ancestrais do Continente Asiático/genética , China , Feminino , Genótipo , Humanos , Neoplasias Pulmonares/cirurgia , Masculino , Pessoa de Meia-Idade , Medição da Dor , Dor Pós-Operatória/tratamento farmacológico , Polimorfismo de Nucleotídeo Único/genética , Fatores de Tempo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...