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1.
Front Immunol ; 12: 673693, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34408744

RESUMO

Background: Thymosin alpha 1 (Tα1) is widely used to treat patients with COVID-19 in China; however, its efficacy remains unclear. This study aimed to explore the efficacy of Tα1 as a COVID-19 therapy. Methods: We performed a multicenter cohort study in five tertiary hospitals in the Hubei province of China between December 2019 and March 2020. The patient non-recovery rate was used as the primary outcome. Results: All crude outcomes, including non-recovery rate (65/306 vs. 290/1,976, p = 0.003), in-hospital mortality rate (62/306 vs. 271/1,976, p = 0.003), intubation rate (31/306 vs. 106/1,976, p = 0.001), acute respiratory distress syndrome (ARDS) incidence (104/306 vs. 499/1,976, p = 0.001), acute kidney injury (AKI) incidence (26/306 vs. 66/1,976, p < 0.001), and length of intensive care unit (ICU) stay (14.9 ± 12.7 vs. 8.7 ± 8.2 days, p < 0.001), were significantly higher in the Tα1 treatment group. After adjusting for confounding factors, Tα1 use was found to be significantly associated with a higher non-recovery rate than non-Tα1 use (OR 1.5, 95% CI 1.1-2.1, p = 0.028). An increased risk of non-recovery rate associated with Tα1 use was observed in the patient subgroups with maximum sequential organ failure assessment (SOFA) scores ≥2 (OR 2.0, 95%CI 1.4-2.9, p = 0.024), a record of ICU admission (OR 5.4, 95%CI 2.1-14.0, p < 0.001), and lower PaO2/FiO2 values (OR 1.9, 95%CI 1.1-3.4, p = 0.046). Furthermore, later initiation of Tα1 use was associated with a higher non-recovery rate. Conclusion: Tα1 use in COVID-19 patients was associated with an increased non-recovery rate, especially in those with greater disease severity.


Assuntos
COVID-19/tratamento farmacológico , Síndrome do Desconforto Respiratório/epidemiologia , Timalfasina/efeitos adversos , Adulto , Idoso , COVID-19/complicações , COVID-19/diagnóstico , COVID-19/mortalidade , Feminino , Mortalidade Hospitalar , Humanos , Unidades de Terapia Intensiva/estatística & dados numéricos , Tempo de Internação/estatística & dados numéricos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Escores de Disfunção Orgânica , Prognóstico , Síndrome do Desconforto Respiratório/etiologia , Síndrome do Desconforto Respiratório/prevenção & controle , Estudos Retrospectivos , Medição de Risco/estatística & dados numéricos , Timalfasina/administração & dosagem , Resultado do Tratamento
2.
Biomed Pharmacother ; 142: 112061, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34449313

RESUMO

CRISPR/Cas9 system has been used as the most powerful gene editing tool for precision medicine and advanced gene therapy. However, its wide applications are limited by the poor biosafety of lentivirus delivery vectors though with high-efficiency transduction. To construct a safer vector and promote genome integration, the CRISPR/Cas9 gene is cloned into a plasmid-based non-viral safe vector Sleeping-Beauty (SB) transposon in this study to obtain pT2SpCas9. Meanwhile, PDA/DEX-PEI@HA (PDPH) nanoparticles are constructed to facilitate the precise CRISPR/Cas9 targeting delivery, by using polydopamine (PDA) as the carrier, hyaluronic acid (HA) as the cell-targeting ligand and dexamethasone (DEX) as the nuclear localization signal (NLS). The results showed that PDPH could deliver pDNA efficiently into the cell and further into the nucleus. The transfection efficiency of PDPH is much higher than that of NPs without HA and DEX. Remarkably, the cytotoxicity of PDPH is negligible in comparison to PEI25k and PEI10k. Western blots showed that after the transfection of PDPH/pT2SpCas9-Nanog/SB11, Nanog protein in HeLa cells is knocked out, and the proliferation and migration abilities of tumor cells are significantly decreased. This study demonstrates that PDA/DEX-PEI25k@HA/pT2SpCas9 (PDPH25 K/pT2SpCas9) has the great potential as a non-viral gene vector for CRISPR/Cas9 delivery and clinical medication.

3.
Adv Sci (Weinh) ; 8(18): e2100825, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34338437

RESUMO

The nanomechanical properties of tumor-derived small extracellular vesicles (sEVs) are essential to cancer progression. Here, nanoindentation is utilized on atomic force microscopy (AFM) to quantitatively investigate the nanomechanical properties of human breast cancer cell-derived sEVs at single vesicle level and explore their relationship with tumor malignancy and vesicle size. It is demonstrated that the stiffness of the sEVs results from the combined contribution of the bending modulus and osmotic pressure of the sEVs. The stiffness and osmotic pressure increase with increasing malignancy of the sEVs and decrease with increasing size of the sEVs. The bending modulus decreases with increasing malignancy of the sEVs and is lower in smaller sEVs. This study builds relationship between the nanomechanical signature of the sEV and tumor malignancy, adding information for better understanding cancer mechanobiology.

4.
Opt Lett ; 46(14): 3332-3335, 2021 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-34264206

RESUMO

This Letter demonstrates the nonlinear conversion of asymmetric perfect vortex (APV) beams with fractional orbital angular momentum (OAM). By controlling the amplitude and phase of the fundamental light field, we create APVs whose global OAM demonstrates a one-to-one correspondence of the charge numbers for fractional OAM values. The results show that the OAM of the second-harmonic generation fields follow the OAM conservation law. The nonlinear interactions of multiple OAM beams with the APVs are also investigated as they relate to the nonlinear frequency conversion and are shown to exhibit unique frequencies as a result of the Doppler frequency tagged OAM values.

5.
Appl Opt ; 60(15): 4282-4290, 2021 May 20.
Artigo em Inglês | MEDLINE | ID: mdl-34143114

RESUMO

The feasibility of near-infrared spectroscopy (NIRS) combined with chemometrics for the rapid detection of the cellulose and hemicellulose contents in corn stover is discussed. Competitive adaptive reweighted sampling (CARS) and genetic simulated annealing algorithm (GSA) were combined (CARS-GSA) to select the characteristic wavelengths of cellulose and hemicellulose and to reduce the dimensionality and multicollinearity of the NIRS data. The whole spectra contained 1845 wavelength variables. After CARS-GSA optimization, the number of characteristic wavelengths of cellulose (hemicellulose) was reduced to 152 (260), accounting for 8.24% (14.09%) of all wavelengths. The coefficients of determination of the regression models for predicting the cellulose and hemicellulose contents were 0.968 and 0.996, the root mean square errors of prediction (RMSEPs) were 0.683 and 0.648, and the residual predictive deviations (RPDs) were 5.213 and 16.499, respectively. The RMSEP of the cellulose and hemicellulose regression models was 0.152 and 0.190 lower for CARS-GSA than for the full-spectrum, and the RPD was increased by 0.949 and 3.47, respectively. The results showed that the CARS-GSA model substantially reduced the number of characteristic wavelengths and significantly improved the predictive ability of the regression model.

6.
J Phys Chem Lett ; : 5571-5579, 2021 Jun 09.
Artigo em Inglês | MEDLINE | ID: mdl-34106708

RESUMO

Multidimensional perovskite techniques are of intense research interest since they are proved to be advantageous to enhance the perovskite stability. Thereinto, the structure engineering strategy has been widely used to regulate the low dimensional (LD) perovskite structures and obtain expected optoelectronic properties. In this work, we intercalate a thus far unreported metallic coordination compound [Ga-Tpy2]3+ (Tpy: 2,2';6',2″-terpyridine) to the inorganic Pb-I building block as the A-site organic group, and the zero dimensional (0D) [Ga-Tpy2]PbI5 perovskite-like single crystal is obtained. This material displays suitable band edge levels, which enable its potential application as light absorber in solar cells. The DFT calculations manifest delocalized charge distribution on Tpy ligands that can facilitate electron transport, which is attributed to the formation of a double hybrid coordinate bond, i.e., σ bonds and π bonds, between Ga3+ ions and Tpy ligands. These coordinate bonds make metallic complexes promising molecules to regulate structure-associated optoelectronic performances of the LD perovskites.

7.
Cancer Sci ; 112(8): 3349-3362, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34014591

RESUMO

Epstein-Barr virus (EBV) is associated with approximately 10% of gastric cancers (GCs). We previously showed that EBV infection of gastric epithelial cells induces aberrant DNA methylation in promoter regions, which causes silencing of critical tumor suppressor genes. Here, we analyzed gene expressions and active histone modifications (H3K4me3, H3K4me1, and H3K27ac) genome-widely in EBV-positive GC cell lines and in vitro EBV-infected GC cell lines to elucidate the transcription factors contributing to tumorigenesis through enhancer activation. Genes associated with "signaling of WNT in cancer" were significantly enriched in EBV-positive GC, showing increased active ß-catenin staining. Genes neighboring activated enhancers were significantly upregulated, and EHF motif was significantly enriched in these active enhancers. Higher expression of EHF in clinical EBV-positive GC compared with normal tissue and EBV-negative GC was confirmed by RNA-seq using The Cancer Genome Atlas cohort, and by immunostaining using our cohort. EHF knockdown markedly inhibited cell proliferation. Moreover, there was significant enrichment of critical cancer pathway-related genes (eg, FZD5) in the downstream of EHF. EBV protein LMP2A caused upregulation of EHF via phosphorylation of STAT3. STAT3 knockdown was shown to inhibit cellular growth of EBV-positive GC cells, and the inhibition was rescued by EHF overexpression. Our data highlighted the important role of EBV infection in gastric tumorigenesis via enhancer activation.


Assuntos
Infecções por Vírus Epstein-Barr/genética , Herpesvirus Humano 4/metabolismo , Fator de Transcrição STAT3/metabolismo , Neoplasias Gástricas/virologia , Fatores de Transcrição/genética , Proteínas da Matriz Viral/metabolismo , Linhagem Celular Tumoral , Metilação de DNA , Infecções por Vírus Epstein-Barr/metabolismo , Perfilação da Expressão Gênica , Regulação Neoplásica da Expressão Gênica , Regulação Viral da Expressão Gênica , Código das Histonas , Humanos , Fosforilação , Análise de Sequência de RNA , Neoplasias Gástricas/genética , Neoplasias Gástricas/metabolismo , Fatores de Transcrição/metabolismo , Regulação para Cima
8.
Brain Res Bull ; 173: 116-123, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-33991608

RESUMO

Sialylation, one of the most common and complex modes of glycosylation, corresponds with the development of the infant brain and nervous system. The most prevalent neurodegenerative disease is Alzheimer's disease (AD), which is mainly characterized by cognitive decline and behavioral disorders. However, the relationship between sialylation and AD occurrence is poorly understood. In this article, we reviewed the role of sialylation on the occurrence and development of AD, then discussed the value of sialylation modification for AD diagnosis and treatment.

9.
Small ; : e2100888, 2021 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-34032381

RESUMO

Despite the rapid development of CsPbIx Br3- x (0 ≤ x ≤ 3) inorganic perovskite solar cells, associated with their superior thermal stability, their low moisture stability limits their commercial deployment. In this study, 1D-2D-3D multidimensional coupled perovskites are prepared by means of an in situ self-integration approach. This pioneering method allows incorporating thus far unreported 1D-Tpy2 Pb3 I6 and 2D-TpyPb3 I6 (Tpy; terpyridine) perovskites. Heterojunction perovskites demonstrate superior stability against water in comparison with control 3D CsPbI2 Br, which is related to the hydrophobicity of low-dimension (LD) perovskites. Remarkably, the spontaneous involvement of LD perovskites can adjust/reconstruct the interfacial structure. This modification allows releasing the residual strain, establishing effective charge transfer channels that increase the carrier transport ability. Accordingly, 1D-2D-3D hybrid CsPbI2 Br perovskite solar cells demonstrate a stabilized power conversion efficiency as high as 16.1%, which represents a very significant improvement, by a factor of 43%, with respect to control 3D CsPbI2 Br perovskite solar cell. Equally importantly, the multidimensional coupled perovskite solar cells exhibit extraordinary stability, well above 1000 h in ambient atmosphere.

10.
Bioresour Technol ; 333: 125204, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-33932811

RESUMO

In this study, Anaerobic Digestion Model No. 1 (ADM1) were modified to simulate anaerobic digestion (AD) process of microcrystalline cellulose (MCC) and five lignocellulosic substrates, with the goal of predicting the hydrolysis rates of holocellulose fractions in environments with and without lignin inhibition. After model verification, the hydrolysis rate constant of MCC, i.e., the hydrolyzability of cellulose without lignin inhibition, was 3.227 d-1, while those of the holocellulose fractions of five lignocellulosic substrates (I_khyd) were in the range of 1.270 d-1 to 3.364 d-1 (average of 2.242 d-1), which demonstrated remarkable suppression of holocellulose hydrolysis by lignin. Lignin inhibition index (LII) was proposed as an indicator to intuitively quantify and characterize the lignin inhibitory strength in a specific substrate. A series of factors with the potential to affect the LII were analyzed sequentially. This study provides an advanced understanding of the participation and behavior of lignin in the AD process.


Assuntos
Lignina , Anaerobiose , Hidrólise , Lignina/metabolismo
11.
Chemosphere ; 280: 130785, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33971420

RESUMO

Recently, Mn oxides (MnOxs) have been attracting considerable interest in the oxidation of organic pollutants. However, the reduction of MnOx in these reactions leads to the deactivation of the catalyst, which must be frequently regenerated. We evaluated the application of a manganese-oxidizing bacterium (MOB) and MnOx in removing toxic dyes. We studied the co-function of a plant-endophytic MOB, Pantoea eucrina SS01, with its bio-generated MnOx and evaluated the detoxification activity and chemical transformation mechanisms of the complex in malachite green (MG) degradation. We found a synergistic effect between MnOx and the strain. Particularly, strain SS01 could adsorb MG but could not degrade it, whereas the addition of Mn(II) promoted MG degradation by the formation of a complex containing the bacterium and MnOx aggregates (SS01-bio-MnOx), with distinct morphology characteristics. The complex showed a marked sustainability in the degradation of MG into less toxic or non-toxic metabolites. In this process, strain SS01 might have enhanced the regeneration of MnOx, accelerating MG degradation. Our data not only contribute to understanding the mechanism of MG removal by the SS01-bio-MnOx complex, but also provide a scientific basis for the future application of MOB and MnOx.


Assuntos
Manganês , Óxidos , Compostos de Manganês , Oxirredução , Pantoea , Corantes de Rosanilina
12.
Nat Prod Res ; : 1-3, 2021 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-33980087

RESUMO

The inhibitory effect of three degraded sesquiterpene lactones, iso-seco-tanapartholide, arteludooicinolide A and millifolide A isolated from Achillea millefolium L., on anti-human lung cancer cells was examined using MTT and reporter gene assays. Millifolide A has significant inhibitory effects on the proliferation of human lung cancer cells probably through inducing cell apoptosis.

13.
Angew Chem Int Ed Engl ; 60(26): 14512-14520, 2021 06 21.
Artigo em Inglês | MEDLINE | ID: mdl-33860575

RESUMO

Noninvasive imaging strategies have been extensively investigated for in vivo mapping of sentinel lymph nodes (SLNs). However, the current imaging strategies fail to accurately assess tumor metastatic status in SLNs with high sensitivity. Here we report pH-amplified self-illuminating near-infrared nanoparticles, which integrate chemiluminescence resonance energy transfer (CRET) and signal amplification strategy, enabling accurate identification of metastatic SLNs. After draining into lymph nodes, the nanoparticles were phagocytosed and dissociated in acidic phagosomes of inflammatory macrophages to emit near-infrared luminescent light. Using these nanoparticles, we successfully differentiated tumor metastatic lymph nodes from benign ones. These nanoparticles also exhibited excellent imaging capability for early detection of metastatic SLNs in diverse animal tumor models with small tumor volume (100-200 mm3 ).


Assuntos
Transferência Ressonante de Energia de Fluorescência , Linfonodos/patologia , Linfoma/patologia , Nanopartículas/química , Humanos , Concentração de Íons de Hidrogênio
14.
BMC Infect Dis ; 21(1): 398, 2021 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-33926377

RESUMO

BACKGROUND: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammatory event and a fatal complication of viral infections. Whether sHLH may also be observed in patients with a cytokine storm induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still uncertain. We aimed to determine the incidence of sHLH in severe COVID-19 patients and evaluate the underlying risk factors. METHOD: Four hundred fifteen severe COVID-19 adult patients were retrospectively assessed for hemophagocytosis score (HScore). A subset of 7 patients were unable to be conclusively scored due to insufficient patient data. RESULTS: In 408 patients, 41 (10.04%) had an HScore ≥169 and were characterized as "suspected sHLH positive". Compared with patients below a HScore threshold of 98, the suspected sHLH positive group had higher D-dimer, total bilirubin, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, serum creatinine, triglycerides, ferritin, interleukin-6, C-reactive protein, procalcitonin, lactate dehydrogenase, creatine kinase isoenzyme, troponin, Sequential Organ Failure Assessment (SOFA) score, while leukocyte, hemoglobin, platelets, lymphocyte, fibrinogen, pre-albumin, albumin levels were significantly lower (all P < 0.05). Multivariable logistic regression revealed that high ferritin (>1922.58 ng/mL), low platelets (<101 × 109/L) and high triglycerides (>2.28 mmol/L) were independent risk factors for suspected sHLH in COVID-19 patients. Importantly, COVID-19 patients that were suspected sHLH positive had significantly more multi-organ failure. Additionally, a high HScore (>98) was an independent predictor for mortality in COVID-19. CONCLUSIONS: HScore should be measured as a prognostic biomarker in COVID-19 patients. In particular, it is important that HScore is assessed in patients with high ferritin, triglycerides and low platelets to improve the detection of suspected sHLH.


Assuntos
COVID-19/complicações , Linfo-Histiocitose Hemofagocítica/etiologia , Adulto , Idoso , Aspartato Aminotransferases/sangue , COVID-19/epidemiologia , COVID-19/terapia , China/epidemiologia , Comorbidade , Síndrome da Liberação de Citocina/complicações , Síndrome da Liberação de Citocina/virologia , Feminino , Ferritinas/sangue , Humanos , Incidência , Contagem de Linfócitos , Linfo-Histiocitose Hemofagocítica/epidemiologia , Linfo-Histiocitose Hemofagocítica/mortalidade , Masculino , Pessoa de Meia-Idade , Mortalidade , Estudos Retrospectivos , Fatores de Risco
15.
J Drug Target ; 29(8): 884-891, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-33571019

RESUMO

Nano graphene oxide (NGO) has high drug-loading capacity due to its huge surface area. However, the limited stability and the poor biocompatibility of NGO hampered its application as drug delivery carrier under physiological conditions. Thereby, a new strategy of using chemical conjugation on NGO with hydrophilic polymers was adopted but currently was too complicated, low yield and costly. In this study, doxorubicin-hyd-PEG-folic acid (DOX-hyd-PEG-FA) polymers were coated on the surface of NGO via π-π stocking and the hydrophobic effect between DOX and NGO. With the PEG shell protection, the biocompatibility of NGO was significantly improved. The drug-loading capacity of nanoparticles was more than 100%. FA ligands on the nanoparticle could guide the nanoparticles actively targeting to tumour cells. The hydrazone bond between DOX and PEG was decomposed spontaneously in the weakly acidic environment, which made PEG layer dissociated from NGO. Furthermore, DOX was easily protonized at low pH conditions, which weakened the interaction between DOX and NGO. Thus, DOX could be released rapidly from the nanoparticles in tumour cells. In summary, NGO@DOX-hyd-PEG-FA is an easy-prepared nanoparticle with excellent biocompatibility, high pH-sensitivity and active tumour targeting. Therefore, it is a promising multifunctional nanocarrier effective for targeted drug delivery.

16.
J Proteomics ; 234: 104098, 2021 03 15.
Artigo em Inglês | MEDLINE | ID: mdl-33421637

RESUMO

Previously, we developed a novel separation technique, namely, supported molecular matrix electrophoresis (SMME), which separates mucins on a PVDF membrane that impregnated with a hydrophilic polymer (such as polyvinyl alcohol), so it has the characteristics that are compatible with glycan analysis of the separated bands. Here, we describe the first instance of the application of SMME to mouse sera fractionation and demonstrate their differences from the pooled human sera fractionation by SMME. Furthermore, we have developed a fixation method for the lectin blotting of SMME-separated glycoproteins by immersing the SMME membranes into acetone solvent followed by heating. It showed that the amount of protein samples required for SMME were reduced more than 4-fold than that of the process of SDS-PAGE. We applied these techniques for the detection of glycosylation patterns of serum proteins from Fut8+/+ and Fut8-/- mice, further analyzed N-linked and O-linked glycans from the separated γ-bands by mass spectrometry, and demonstrated that there are α2,8-sialylated O-glycans contained in mouse sera glycoproteins. SMME can provide simple, rapid sera fractionation, glycan profiling differences between the bands of two samples and a new insight into the underlying mechanism that responsible for related diseases. SIGNIFICANCE: We describe that the first application of SMME can separate mouse serum proteins into six bands and identify the major protein components of each fraction in mouse serum separated by SMME. Furthermore, we successfully developed a fixation method for lectin blotting of SMME-separated glycoproteins and applied to the detection of glycosylation patterns of serum glycoproteins from Fut8+/+ and Fut8-/- mice, also, the method is promising for detecting glycan profiling differences between two samples in both research and clinical settings.


Assuntos
Glicoproteínas , Mucinas , Animais , Eletroforese , Glicosilação , Camundongos , Polissacarídeos
17.
Bioresour Technol ; 321: 124449, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33285506

RESUMO

In this study, a rapid detection method based on near-infrared reflectance spectroscopy was proposed for measuring the contents of cellulose, hemicellulose and lignin in corn stover. In the basis of strategies of variable selection, feature extraction and nonlinear modeling, BiPLS-PCA-SVM was constructed using backward interval partial least squares combined with principal component analysis and support vector machine, which was used to improve the performance of spectral regression calibration model. For BiPLS-PCA-SVM model, the determination coefficients, root mean squared error and residual predictive deviation for the validation set were 0.906, 0.900% and 3.213 for cellulose; 0.987, 0.797% and 9.071 for hemicellulose; and 0.936, 0.264% and 4.024 for lignin, correspondingly. The results indicate that near-infrared reflectance spectroscopy combined with BiPLS-PCA-SVM can provide a reliable alternative strategy to detect contents of lignocellulosic components for pretreated corn stover in the anaerobic digestion process.


Assuntos
Lignina , Zea mays , Análise dos Mínimos Quadrados , Espectroscopia de Luz Próxima ao Infravermelho , Máquina de Vetores de Suporte
18.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 37(6): 1031-1036, 2020 Dec 25.
Artigo em Chinês | MEDLINE | ID: mdl-33369342

RESUMO

To investigate the computed tomography (CT) characteristics and differential diagnosis of high altitude pulmonary edema (HAPE) and COVID-19, CT findings of 52 cases of HAPE confirmed in Medical Station of Sanshili Barracks, PLA 950 Hospital from May 1, 2020 to May 30, 2020 were collected retrospectively. The size, number, location, distribution, density and morphology of the pulmonary lesions of these CT data were analyzed and compared with some already existed COVID-19 CT images which come from two files, "Radiological diagnosis of COVID-19: expert recommendation from the Chinese Society of Radiology (First edition)" and "A rapid advice guideline for the diagnosis and treatment of 2019 novel corona-virus (2019-nCoV) infected pneumonia (standard version)". The simple or multiple ground-glass opacity (GGO) lesions are located both in the HAPE and COVID-19 at the early stage, but only the thickening of interlobular septa, called "crazy paving pattern" belongs to COVID-19. At the next period, some increased cloudy shadows are located in HAPE, while lesions of COVID-19 are more likely to develop parallel to the direction of the pleura, and some of the lesions show the bronchial inflation. At the most serious stage, both the shadows in HAPE and COVID-19 become white, but the lesions of HAPE in the right lung are more serious than that of left lung. In summary, some cloudy shadows are the feature of HAPE CT image, and "crazy paving pattern" and "pleural parallel sign" belong to the COVID-19 CT, which can be used for differential diagnosis.


Assuntos
Altitude , COVID-19/diagnóstico por imagem , Edema Pulmonar/diagnóstico por imagem , China , Diagnóstico Diferencial , Humanos , Pulmão/diagnóstico por imagem , Estudos Retrospectivos , Tomografia Computadorizada por Raios X
19.
Respir Med ; 173: 106159, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-33010731

RESUMO

BACKGROUND: The outbreak of COVID-19 caused by SARS-CoV-2 has been a pandemic. The objective of our study was to explore the association between sex and clinical outcomes in patients with COVID-19. METHODS: Detailed clinical data including clinical characteristics, laboratory tests, imaging features and treatments of 1190 cases of adult patients with confirmed COVID-19 were retrospectively analyzed. Associations between sex and clinical outcomes were identified by multivariable Cox regression analysis. RESULTS: There were 635 (53.4%) male and 555 (46.6%) female patients in this study. Higher rates of acute kidney injury (5.5% vs. 2.9%, p = 0.026), acute cardiac injury (9.1% vs. 4.3%, p = 0.001), and disseminated intravascular coagulation (2.5% vs. 0.7%, P = 0.024) were observed in males. Compared with female patients, male patients with COVID-19 had a higher inhospital mortality rate (15.7% vs. 10.3%, p = 0.005). However, Cox regression analysis showed that sex did not influence inhospital mortality of COVID-19 patients. CONCLUSIONS: Male sex was associated with a worse prognosis of COVID-19, but it seems not to be an independent prognostic factor.


Assuntos
Betacoronavirus , Infecções por Coronavirus/complicações , Infecções por Coronavirus/epidemiologia , Pneumonia Viral/complicações , Pneumonia Viral/epidemiologia , Adulto , Idoso , COVID-19 , China , Infecções por Coronavirus/terapia , Feminino , Mortalidade Hospitalar , Hospitalização , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação de Resultados em Cuidados de Saúde , Pandemias , Pneumonia Viral/terapia , Estudos Retrospectivos , Fatores de Risco , SARS-CoV-2 , Fatores Sexuais
20.
J Phys Chem Lett ; 11(22): 9535-9542, 2020 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-33115233

RESUMO

Lead-free double perovskites have attracted noteworthy attention due to their compositional flexibility and electronic diversity. In this study, we hydrothermally grow a new class of Cs2AgxNa1-xFeCl6 (0 ≤ x ≤ 1) perovskite single crystals with high thermal stability. The substitution of B-site cation allows to regulate the crystallographic and band structure, which gives rise to enlarged band absorbance close to the near-infrared region (∼800 nm) via composition engineering. Ultrafast transient absorption spectroscopy (TAS) certifies that the decay time of excited-state absorption is 5.02 and 2450 ps in the case of Cs2NaFeCl6 and Cs2AgFeCl6, respectively. The corresponding charge carrier diffusion length accordingly enhances from 3.7 to 311 nm by means of increasing Ag dopant concentration. Structurally, the primitive cell shrinks due to the partial replacement of [NaCl6]5- octahedra by [AgCl6]5- octahedra. It is proved theoretically as well as experimentally that the introduction of Ag species can effectively enhance the electron mobility (from 1.06 to 15.3 cm2 V-1 s-1) by ∼15 times through realizing stronger orbital coupling of the conductive ions, which enables such a novel double perovskite to be a potential candidate for the optoelectronic and photovoltaic applications.

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