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1.
Asian J Surg ; 2022 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-35525691

RESUMO

OBJECTIVE: This study was to explore the risk factors for postoperative bladder neck contracture (BNC) after transurethral operation of prostate in patients with small-volume prostatic obstruction. METHODS: Clinicopathologic data at our center from February 2016 to January 2020 were retrospectively collected and analyzed. Clinicopathological characteristics between patients with and without BNC were compared. Multivariate logistic regression was used to determine the risk factors for postoperative BNC. RESULTS: There were a total of 39 patients (8.53%) with postoperative BNC. Multivariate logistic regression analysis demonstrated that preoperative bladder neck diameter (BND), intravesical prostatic protrusion (IPP), surgical methods (transurethral resection of prostate (TURP)/anatomical endoscopic enucleation of the prostate (AEEP)), and postoperative urinary tract infection (UTI) were independent risk factors for postoperative BNC in patients with small-volume prostatic obstruction (P < 0.05). The incidence of postoperative BNC in patients undergoing AEEP was significantly decreased compared with those undergoing TURP. The optimal cut-off value of preoperative IPP was 6.10 mm while the optimal cut-off value of preoperative BND was 2.52 cm. CONCLUSIONS: Larger preoperative bladder neck and higher preoperative IPP lead to decreased incidence of postoperative BNC in patients with small-volume prostatic obstruction. Active management of postoperative UTI could effectively prevent the occurrence of postoperative BNC. Compared with TURP, complete AEEP would contribute to reduce BNC in patients with small-volume prostatic obstruction.

2.
Sci Total Environ ; 834: 155314, 2022 Apr 18.
Artigo em Inglês | MEDLINE | ID: mdl-35447194

RESUMO

Organosulfates (OSs) are important secondary organic aerosol (SOA) species in atmospheric fine particles (PM2.5) and can be considered as molecular indicators of SOA. To understand their seasonal and diurnal distribution characteristics and formation mechanism in northern China, PM2.5 samples collected in daytime and nighttime in winter and summer 2019 in Tianjin, China were studied for total OSs and three OS species (methyl sulfate (MS), glycolic acid sulfate (GAS), benzyl sulfate (BS)). The S contents of total OSs (SOSs) in winter and summer were 0.6 ± 1 µg m-3 and 0.4 ± 0.3 µg m-3, respectively, in PM2.5. BS found to be less abundant among the measured species, and accounted for only 0.8%-4.8% of methyl sulfate (MS), and 0.01%-0.3% of glycolic acid sulfate (GAS). Average content of GAS was higher in summer than in winter, while that of MS and BS were opposite. The fractions of MS, GAS, and BS in SOSs were higher in daytime than that in night during winter, despite their concentrations were higher in nighttime, indicating that the concentrations of unidentified OS species were much higher in nighttime than in daytime. Such diurnal variations implied that relative humidity (RH) played a major role in the formation processes of OSs, especially biogenic OSs and the acid catalyzed reaction of SO42- might be a main pathway of OSs formation during winter. High T, RH and O3 determined biological GAS in summer, while NO2 and SO2 determined anthropogenic OSs in winter. We also found that the fractions of SOSs in S contents of organic sulfur (SOS) and the S contents of MS + GAS+BS (SMS+GAS+BS) in SOSs were accounted for only less than 10% and 5%, respectively. Therefore, this study suggests the components of OS and OSs in PM2.5 have not been discovered fully yet and needs further research.

3.
Sci Total Environ ; 834: 155392, 2022 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-35461932

RESUMO

Hydropower plays an important role in the supply of renewable energy, but it also exerts a great influence on the river continuum. Understanding nutrient cycling and microbial community succession in hydropower reservoirs is key to weighing hydroelectric pros and cons. However, the underlying control mechanisms are still not well known, especially with respect to the impacts of hydrological conditions. Based on a comprehensive survey of hydropower reservoirs along the Wujiang River in SW China and an integration of published data, we found that reservoir physicochemical and biological stratifications and planktonic microbial community assembly were synergistically evolving, and reservoir hydraulic load (i.e., mean water depth per unit retention time) was a key factor controlling the strength of stratifications, CO2 and N2O fluxes, nutrient retention efficiency, and bacterioplankton diversity. Hydraulic loads are artificially designed for hydropower reservoirs, and nutrient cycling and biological succession in reservoirs are thus governed by anthropogenic regulation. This study provides a theoretical basis to mitigate the environmental impacts of hydropower dams by regulating reservoir hydraulic load.

4.
Front Plant Sci ; 13: 826902, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35360317

RESUMO

Rhizomes of the Polygonatum species are well-known in traditional Chinese medicine. The 2020 edition of Chinese Pharmacopoeia includes three different species that possess different pharmacological effects. Due to the lack of standardized discriminant compounds there has often been inadvertently incorrect prescriptions given for these medicines, resulting in serious consequences. Therefore, it is critical to accurately distinguish these herbal Polygonatum species. For this study, UPLC-Q-TOF-MS/MS based metabolomics was employed for the first time to discriminate between three Polygonatum species. Partial least squares discriminant analysis (PLS-DA) models were utilized to select the potential candidate discriminant compounds, after which MS/MS fragmentation patterns were used to identify them. Meanwhile, metabolic correlations were identified using the R language package corrplot, and the distribution of various metabolites was analyzed by box plot and the Z-score graph. As a result, we found that adenosine, sucrose, and pyroglutamic acid were suitable for the identification of different Polygonatum species. In conclusion, this study articulates how various herbal Polygonatum species might be more accurately and efficiently distinguished.

5.
J Vet Pharmacol Ther ; 45(3): 291-300, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35348230

RESUMO

A pharmacokinetic/pharmacodynamic (PK/PD) model was developed to optimize the dosing regimen of enrofloxacin (EN) against Glaesserella parasuis in pigs. EN (2.5 mg/kg) was administered intramuscularly to eight healthy pigs and eight pigs that were experimentally infected with G. parasuis SW124. Blood samples were collected at predetermined time points. Plasma EN concentrations were determined, and the main PK parameters were estimated. The PD of EN against G. parasuis SW124 was also investigated in vitro and ex vivo. The dynamic behaviour of EN in pigs was consistent with a one-compartment model. Significant differences were observed between healthy and infected pigs in the area under the curve (AUC) (3.58 ± 0.94 and 5.39 ± 1.01 µg h/ml, respectively) and the systemic clearance (CL) (736.32 ± 171.46 and 479.36 ± 96.81 ml/h/kg, respectively), suggesting that the pathogenicity of G. parasuis SW124 to pigs might alter the PK profile of EN, and therefore should be considered in dose optimization. Both the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were 0.125 µg/ml in tryptone soya broth (TSB) medium or plasma. The mutant prevention concentration (MPC) was 0.6 µg/ml. EN inhibited or killed G. parasuis SW124 in a concentration-dependent manner. The targeted endpoints of AUC24 h /MIC for bacteriostasis, bactericidal action, and eradication were 5.10, 7.34, and 8.65 h and 5.91, 9.01, and 10.90 h in healthy and infected pigs, respectively. The optimal doses were 3.58-6.08 mg/kg in healthy pigs and 2.71-4.99 mg/kg in infected pigs from the point of view of preventing drug resistance.


Assuntos
Antibacterianos , Haemophilus parasuis , Animais , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Área Sob a Curva , Enrofloxacina , Testes de Sensibilidade Microbiana/veterinária , Suínos
6.
Am J Cancer Res ; 12(2): 816-828, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35261804

RESUMO

Small nucleolar RNA host gene 15 (SNHG15) is upregulated in many malignancies and mediates the development of multiple cancers, including osteosarcoma (OS). However, data on the regulatory mechanisms and role of SNHG15 in the chemoresistance of OS remain scarce. Here, we show that p53 binds to the SNHG15 promoter, leading to decreased SNHG15 expression. Decreased SNHG15 expression promotes cisplatin-induced apoptosis and reactive oxygen species (ROS) accumulation in OS cells. Furthermore, SNHG15 sponges and inhibits the activity of endogenous miR-335-3p, leading to the upregulation of zinc finger protein 32 (ZNF32). Taken together, these findings reveal that p53 downregulates SNHG15 expression in OS. In addition, SNHG15 suppresses cisplatin-induced apoptosis and ROS accumulation through the miR-335-3p/ZNF32 pathway.

7.
Artigo em Inglês | MEDLINE | ID: mdl-35288857

RESUMO

Cement kiln collaborative disposal technology can not only dispose of hazardous waste but also provide energy for the cement industry. However, the addition of hazardous waste may promote the formation of dioxins in cement kilns. In this study, typical hazardous solid wastes, such as solidified fly ash, electroplating sludge, and industrial residue, were co-processed in a cement kiln with different feeding positions and different feeding amounts. The concentrations of dioxins in the flue gas, clinker, and precalciner furnace slag were investigated. The effect of adding mixed hazardous solid waste on the formation of dioxin was also studied. The results showed that the concentration of dioxin in the flue gas without added hazardous waste was 1.57 ng/m3, and the concentration varied from 1.03 to 6.49 ng/m3 after the addition of hazardous waste. In addition, the concentration of dioxin in the flue gas and solid samples increased substantially when the co-processing ratio doubled. The large amount of Cu in solidified fly ash promoted the formation of dioxins, while the higher S content in the electroplating sludge suppressed the formation of dioxins. Compared with the addition of single hazardous waste, the concentration of dioxin in precalciner furnace slag increases by about 300%. Furthermore, the distributions of isomers in the clinker and precalciner furnace slag were similar. 1,2,3,4,6,7,8-HpCDD and OCDD accounted for a large proportion of the mass concentration, and the contribution rate ranged from 48.7 to 82.0%. Most importantly, correlation analysis showed that the concentration of dioxin was closely related to the copper content, hazardous waste types and additive proportion, with correlation coefficients of 0.79, 0.83, and 0.89, respectively. This study provides a basis for exploring the high environmental benefits of disposing of hazardous solid waste by co-processing in cement kilns.

8.
Sci Total Environ ; 828: 154537, 2022 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-35292324

RESUMO

Anthropogenic input of sulfate (SO42-) in reservoirs may enhance bacterial sulfate reduction (BSR) under seasonally hypoxic conditions in the water column. However, factors that control BSR and its coupling to organic carbon (OC) mineralization in seasonally hypoxic reservoirs remain unclear. The present study elucidates the coupling processes by analyzing the concentrations and isotopic composition of dissolved inorganic carbon (DIC) and sulfur (SO42-, sulfide) species, and the microbial community in water of the Aha reservoir, SW China, which has high SO42- concentration due to the inputs from acid mine drainage about twenty years ago. The water column at two sites in July and October revealed significant thermal stratification. In the hypoxic bottom water, the δ13C-DIC decreased while the δ34S-SO42- increased, implying organic carbon mineralization due to BSR. The magnitude of S isotope fractionation (Δ34S, obtained from δ34Ssulfate-δ34Ssulfide) during the process of BSR fell in the range of 3.4‰ to 27.0‰ in July and 21.6‰ to 31.8‰ in October, suggesting a change in the community of sulfate-reducing bacteria (SRB). The relatively low water column stability in October compared to that in July weakened the difference of water chemistry and ultimately affected the SRB diversity. The production of DIC (ΔDIC) scaled a strong positive relationship with the Δ34S in July (p < 0.01), indicating that high OC availability favored the survival of incomplete oxidizers of SRB. However, in October, Δ13C-DIC was correlated with the Δ34S in the bottom hypoxic water (p < 0.01), implying that newly degraded OC depleted in 13C could favor the dominance of complete oxidizers of SRB which caused greater S isotope fractionation. Moreover, the sulfide supplied by BSR might stimulate the reductive dissolution of Fe and Mn oxides (Fe(O)OH and MnO2). The present study helps to understand the coupling of C and S in seasonally hypoxic reservoirs characterized by high SO42- concentration.


Assuntos
Carbono , Sulfatos , Bactérias/metabolismo , Carbono/metabolismo , Isótopos de Carbono/análise , China , Dacarbazina/metabolismo , Monitoramento Ambiental , Isótopos , Compostos de Manganês , Óxidos , Sulfatos/análise , Sulfetos/metabolismo , Enxofre/metabolismo , Isótopos de Enxofre/análise , Óxidos de Enxofre/metabolismo , Água/metabolismo
9.
World J Clin Cases ; 10(5): 1609-1616, 2022 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-35211600

RESUMO

BACKGROUND: The prognosis of refractory extranodal natural killer/T-cell lymphoma (ENKTL) is poor. Recent data have indicated that immune checkpoint blockade with a programmed cell death protein-1 (PD-1) antibody in combination with administration of histone deacetylase inhibitors represents a potentially effective treatment strategy. Compared with PD-1 antibodies, programmed death-ligand 1 antibodies have fewer side effects. Here, we present a rare case of a patient with refractory metastatic ENKTL who achieved sustained remission of approximately 10 mo with minor adverse effects after combination therapy with atezolizumab, chidamide, and radiotherapy. CASE SUMMARY: A 56-year-old woman underwent resection of a tumour in her left nasal cavity and was diagnosed with ENKTL (nasal type). Medical examination revealed tumours observed in the bilateral nasal mucosa, the subcutaneous soft tissue of the inner side of the left eye, the soft tissue of the nasopharynx, the bilateral tonsils, and the left preauricular, right hilar, bilateral neck lymph nodes and bone marrow. However, tomography/computed tomography showed increased metabolism of the bilateral nasal mucosa and subcutaneous soft tissue of the inner side of the left eye and newly increased metabolism of the left cervical lymph node after chemotherapy. Therefore, combination therapy with chidamide, atezolizumab, and radiotherapy was performed. Fortunately, the patient achieved a complete response following 10 mo of combination therapy. CONCLUSION: The outcome in this case suggests that the combination of atezolizumab, chidamide, and radiotherapy is a promising regimen for treating refractory metastatic ENKTL following chemotherapy treatment failure.

10.
Infect Immun ; 90(2): e0067021, 2022 02 17.
Artigo em Inglês | MEDLINE | ID: mdl-34978925

RESUMO

Sexually transmitted Chlamydia trachomatis can ascend to the upper genital tract due to its resistance to innate immunity in the lower genital tract. C. trachomatis can activate the cGAS-STING signaling pathway in cultured cells via either cGAS or STING. This study was designed to evaluate the role of the cGAS-STING pathway in innate immunity against C. trachomatis in the mouse genital tract. Following intravaginal inoculation, C. trachomatis significantly declined by day 5 following a peak infection on day 3, while the mouse-adapted Chlamydia muridarum continued to rise for >1 week, indicating that C. trachomatis is susceptible to the innate immunity in the female mouse genital tract. This conclusion was supported by the observation of a similar shedding course in mice deficient in adaptive immunity. Thus, C. trachomatis can be used to evaluate innate immunity in the female genital tract. It was found that mice deficient in either cGAS or STING significantly increased the yields of live C. trachomatis bacteria on day 5, indicating an essential role of the cGAS-STING signaling pathway in innate immunity of the mouse genital tract. Comparison of live C. trachomatis bacteria recovered from different genital tissues revealed that the cGAS-STING-dependent immunity against C. trachomatis was restricted to the mouse lower genital tract regardless of whether C. trachomatis was inoculated intravaginally or transcervically. Thus, we have demonstrated an essential role of the cGAS-STING signaling pathway in innate immunity against chlamydial infection, laying a foundation for further illuminating the mechanisms of the innate immunity in the female lower genital tract.


Assuntos
Infecções por Chlamydia , Chlamydia trachomatis , Animais , Infecções por Chlamydia/microbiologia , Feminino , Genitália Feminina/microbiologia , Camundongos , Nucleotidiltransferases/genética , Transdução de Sinais
11.
Environ Sci Pollut Res Int ; 29(2): 1937-1948, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34363164

RESUMO

The eutrophication of reservoirs can change the physicochemical parameters of water, thus affecting the migration and transformation of heavy metals. At present, there is insufficient research on the coupling mechanisms between nutrients and heavy metals, especially between heavy metals in suspended particles. In this paper, spatial and temporal distribution characteristics of nutrients dissolved heavy metals, and heavy metals in suspended particles were analyzed in a seasonally stratified reservoir. Combined with the nitrogen and phosphorus biogeochemical process, the coupling mechanisms between heavy metals and nutrients were discussed. The results showed that the Aha Reservoir had temperature and dissolved oxygen stratification in April and July. The reduction and dissolution of Fe and Mn oxide/hydroxide and the resuspension of sediments might result in a simultaneous increase in the concentrations of nutrients, dissolved heavy metals and heavy metals in suspended particles in hypolimnion in July and October. In the presence of dissimilatory iron-reducing bacteria (DRIB), the dissolution of iron-bound phosphorus in sediments and suspended particulate matter (SPM) might lead to the simultaneous release of iron and phosphorus into the water. The dissolution of metal sulfides in the sediments and SPM under the action of dissimilatory nitrate reduction to ammonium (DNRA) bacteria might lead to the simultaneous release of ammonia nitrogen and heavy metals into the water. Due to the coupling between nitrogen and phosphorus and heavy metals, seasonal stratified reservoir may face the risk of periodic simultaneous pollution of eutrophication and heavy metals in summer and autumn. This research provides theoretical support for the treatment of heavy metal and eutrophication combined pollution in karst areas.


Assuntos
Metais Pesados , Poluentes Químicos da Água , China , Monitoramento Ambiental , Sedimentos Geológicos , Metais Pesados/análise , Nutrientes , Fósforo/análise , Poluentes Químicos da Água/análise
12.
Harmful Algae ; 111: 102148, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-35016761

RESUMO

Over the last 30 years, harmful algal blooms (HABs) have occurred frequently in the coastal waters of China, resulting in financial losses of over 5.9 billion yuan (about 0.87 billion US dollars) due to massive fish and shellfish mortalities and negative impacts on tourism. To better understand HABs in China, herein we summarized bloom events with massive fish/shellfish mortalities and/or economic losses. Our results suggest that the diversity of HAB species has increased over the last 30 years, with the main causative species shifting from the raphidophyte Chattonella marina and dinoflagellates Gymnodinium spp. to various other species, including the dinoflagellates Karenia mikimotoi and Prorocentrum donghaiense, the haptophyte Phaeocystis globosa, and the pelagophyte Aureococcus anophagefferens. In addition, new types of HABs, such as macroalgal blooms, emerged with severe ecological impacts. We also reviewed the toxic effects, mechanisms, and ecological impacts of common HAB causative species in China. Analysis of the toxic effects of three types of harmful algae (toxin-producing, fish killing, and ecosystem disruptive algae) on marine organisms commonly found in China at different trophic levels revealed that HABs often had toxic effects on multiple organisms in addition to fish or shellfish, with species-specific impacts. Common mechanisms of intoxication include shifting environmental parameters, shellfish poisoning, reactive oxygen species, and haemolytic/cytotoxic toxins. The main mechanism appears to vary with the type of HAB species, and for some notorious algae such as K. mikimotoi and C. marina, further investigations are needed to identify their intoxication mechanism.


Assuntos
Dinoflagelados , Intoxicação por Frutos do Mar , Animais , China , Ecossistema , Proliferação Nociva de Algas
13.
Artigo em Inglês | MEDLINE | ID: mdl-35368769

RESUMO

Background: Bushen Jianpi formula (BSJPF, also known as Lingmao formula) is a traditional Chinese medicine for chronic hepatitis B (CHB). The previous study has suggested that the treatment combination of BSJPF and entecavir (ETV) can achieve a significant loss of hepatitis B e antigen (HBeAg) and a significant decrease in serum level of hepatitis B virus (HBV) DNA in HBeAg-positive CHB patients with mildly elevated alanine aminotransferase. Objective: This study aimed to evaluate the efficacy and safety of BSJPF combined with ETV for treating HBeAg-negative CHB patients. Methods: A total of 640 patients were assigned randomly to the treatment group (receiving BSJPF combined with ETV for 96 weeks) or the control group (receiving a placebo combined with ETV for 96 weeks) in a 1 : 1 ratio. The primary endpoints are the rate of loss of hepatitis B surface antigen (HBsAg). The secondary outcomes included the rate of decrease in the HBsAg concentration to ≥1 lg·IU/mL, the HBV DNA suppression, the decline of the level of covalently closed circular DNA (cccDNA) in the liver, histological improvements, and the rate of ALT normalization. Results: The rate of HBsAg loss in the treatment group was significantly higher than that of the control group (5.5% versus 1.8%, P=0.031). There were 11.1% of patients in the treatment group who recorded a reduction in HBsAg ≥1 lg·IU/mL, which is better than 5.9% of patients in the control group (P=0.043). There was no significant difference between the two groups with regard to the rate of HBV DNA clearance, the reduction in intrahepatic cccDNA, and the rate of ALT normalization (P > 0.05). The rate of liver fibrosis improvement in the treatment group was better than that of the control group (35.5% versus 11.8%, P=0.031), but there was no difference in necroinflammatory improvement (P > 0.05). The adverse events (AEs) were similar between the two groups, except for the abnormal kidney function, with 2.2% in the control group and 0.0% in the treatment group (P=0.028). Conclusion: The combination of BSJPF and ETV can increase the rate of HBsAg loss and the rate of histological fibrosis improvement without serious adverse events in CHB patients. Trial Registration. This trial is registered with ChiCTR-IOR-16009880 on November 16, 2016-retrospectively registered, http://www.chictr.org.cn/showproj.aspx?proj=16836.

14.
J Environ Sci (China) ; 111: 208-219, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34949350

RESUMO

Reservoirs are regarded as hotspots of nitrogen transformation and potential sources of nitrous oxide (N2O). However, it remains unclear how the hydrological conditions due to dam construction control the processes of nitrogen transformation in reservoir waters. To address this issue, we examined the spatial-temporal characteristics of nitrate concentrations, δ15N-NO3-, δ18O-NO3-, δ18O-H2O, relative water column stability (RWCS), and related environmental factors in a subtropical eutrophic reservoir (Hongfeng Reservoir, HFR), Southwest China. We found that denitrification was the most important nitrogen transformation process in the HFR and that higher denitrification intensity was associated with increased RWCS in summer, which suggested hydrological control of the denitrification process. In contrast, low RWCS conditions favored the nitrification process in the HFR in winter. Additionally, dissolved oxygen (DO; p < 0.05) and nitrate concentrations (p < 0.01) had significant impacts on the denitrification rate. We also found that the spatiotemporal RWCS variations were a prerequisite for regulating DO/nitrate stratification and the coupling/decoupling of nitrification-denitrification at the local and global scales. This study would advances our knowledge of the impacts of RWCS and thermal stratification on nitrogen transformation processes in reservoirs.


Assuntos
Desnitrificação , Rios , China , Monitoramento Ambiental , Nitratos/análise , Nitrificação , Nitrogênio/análise , Água
15.
Mil Med Res ; 8(1): 64, 2021 12 09.
Artigo em Inglês | MEDLINE | ID: mdl-34879880

RESUMO

BACKGROUND: Urinary tract infections (UTI), urolithiasis, and benign prostatic hyperplasia (BPH) are three of the most common nonmalignant conditions in urology. However, there is still a lack of comprehensive and updated epidemiological data. This study aimed to investigate the disease burden of UTI, urolithiasis, and BPH in 203 countries and territories from 1990 to 2019. METHODS: Data were extracted from the Global Burden of Disease 2019, including incident cases, deaths, disability-adjusted life-years (DALYs) and corresponding age-standardized rate (ASR) from 1990 to 2019. Estimated annual percentage changes (EAPC) were calculated to evaluate the trends of ASR. The associations between disease burden and social development degrees were analyzed using a sociodemographic index (SDI). RESULTS: Compared with 1990, the incident cases of UTI, urolithiasis, and BPH increased by 60.40%, 48.57%, and 105.70% in 2019, respectively. The age-standardized incidence rate (ASIR) of UTI increased (EAPC = 0.08), while urolithiasis (EAPC = - 0.83) and BPH (EAPC = - 0.03) decreased from 1990 to 2019. In 2019, the age-standardized mortality rate (ASMR) of UTI and urolithiasis were 3.13/100,000 and 0.17/100,000, respectively. BPH had the largest increase (110.56%) in DALYs in the past three decades, followed by UTI (68.89%) and urolithiasis (16.95%). The burden of UTI was mainly concentrated in South Asia and Tropical Latin America, while the burden of urolithiasis and BPH was recorded in Asia and Eastern Europe. Moreover, the ASIR and SDI of urolithiasis in high-SDI regions from 1990 to 2019 were negatively correlated, while the opposite trend was seen in low-SDI regions. In 2019, the ASIR of UTI in females was 3.59 times that of males, while the ASIR of urolithiasis in males was 1.96 times higher than that in females. The incidence was highest in the 30-34, 55-59, and 65-69 age groups among the UTI, urolithiasis, and BPH groups, respectively. CONCLUSION: Over the past three decades, the disease burden has increased for UTI but decreased for urolithiasis and BPH. The allocation of medical resources should be based more on the epidemiological characteristics and geographical distribution of diseases.


Assuntos
Hiperplasia Prostática , Infecções Urinárias , Urolitíase , Feminino , Carga Global da Doença , Humanos , Masculino , Hiperplasia Prostática/epidemiologia , Anos de Vida Ajustados por Qualidade de Vida , Infecções Urinárias/epidemiologia , Urolitíase/epidemiologia
16.
Shanghai Kou Qiang Yi Xue ; 30(5): 543-547, 2021 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-34888611

RESUMO

PURPOSE: To evaluate the efficacy and safety of ultrasound hyperthermia combined with TPF chemotherapy for advanced oral squamous cell carcinoma in the elderly. METHODS: Nineteen elderly patients who had definite pathological diagnosis were enrolled in this clinical trail from June 2017 to January 2020. Docetaxel (75 mg/m2) + cisplatin (75 mg/m2) were given on the 1st day , and 5,Fu (750 mg/m2) on the 1st to 5th day of the cycle. Five times of hyperthermia were performed in the course of chemotherapy, respectively on the l, 3, 5, 7 and 9 days after the beginning of chemotherapy. All patients received 2 cycles of thermo -chemotherapy. Statistical analysis was performed using SPSS 20.0 software package. Kaplan-Meire method was used to calculate survival rate. RESULTS: According to the efficacy evaluation standard for solid tumor (version 1.0), complete response (CR) was seen in 3 cases, partial response (PR) was seen in 10 cases, stable disease(SD) was seen in 5 cases,progressive disease(PD) was seen in 1 case. The overall responding rate was 68.4%. The median follow-up time was 36 months(8-48 months), and the 2-year overall survival rates were 63.2%. No serious adverse reactions were observed. CONCLUSIONS: Ultrasound hyperthermic therapy combined with chemotherapy has a synergistic anti-tumor effect on patients with advanced oral squamous cell carcinoma, which is safe and effective, and is worthy of becoming another choice of tumor treatment.


Assuntos
Carcinoma de Células Escamosas , Neoplasias de Cabeça e Pescoço , Hipertermia Induzida , Neoplasias Bucais , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma de Células Escamosas/tratamento farmacológico , Cisplatino/uso terapêutico , Fluoruracila/uso terapêutico , Humanos , Neoplasias Bucais/tratamento farmacológico , Carcinoma de Células Escamosas de Cabeça e Pescoço , Taxoides/uso terapêutico , Ultrassom
17.
Zhonghua Nan Ke Xue ; 27(8): 718-724, 2021 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-34914244

RESUMO

OBJECTIVE: To investigate the influence of prostatic calculi on the results of prostate biopsy in patients with a PSA level of 4-10 µg/L. METHODS: We reviewed the clinical data on 317 patients with a PSA level of 4-10 µg/L on prostate biopsy performed in The First Affiliated Hospital of Fujian Medical University between May 2012 and May 2019, concerning age, body mass index (BMI), prostate volume, PSA level, FPSA/TPSA ratio, PSA density (PSAD), scores on Prostate Imaging Reporting and Data System version 2 (PI-RADS), prostatic calculi and pathological findings. Using logistic regression analysis and ROC curves, we evaluated the influence of prostatic calculi on the results of prostate biopsy. RESULTS: Multivariate analysis showed that age and the PI-RADS score were independent risk factors of positive prostate biopsy, while the prostate volume, FPSA/TPSA ratio and calculus burden were independent protective factors, and that the PI-RADS score was an independent risk factor of clinically significant PCa, while calculus burden and FPSA/TPSA ratio were independent protective factors. Subgroup analysis of the prostatic calculi revealed that the rates of positive prostate biopsy and clinically significant PCa were higher in the patients with calculi in the peripheral zone than in the other groups, but lower in those with calculi in the central or transitional zone than in the peripheral zone and non-calculus groups. CONCLUSIONS: The rates of positive prostate biopsy and clinically significant PCa are low in prostatic calculus patients with a PSA level of 4-10 µg/L, especially in those with calculi in the central or transitional zone.


Assuntos
Cálculos , Neoplasias da Próstata , Biópsia , Cálculos/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Masculino , Próstata/diagnóstico por imagem , Antígeno Prostático Específico
18.
J Geriatr Cardiol ; 18(11): 857-866, 2021 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-34908923

RESUMO

BACKGROUND: The Trial to Assess Chelation Therapy study found that edetate disodium (disodium ethylenediaminetetraacetic acid) chelation therapy significantly reduced the incidence of cardiac events in stable post-myocardial infarction patients, and a body of epidemiological data has shown that accumulation of biologically active metals, such as lead and cadmium, is an important risk factor for cardiovascular disease. However, limited studies have focused on the relationship between angiographically diagnosed coronary artery disease (CAD) and lead exposure. This study compared blood lead level (BLL) in Chinese patients with and without CAD. METHODS: In this prospective, observational study, 450 consecutive patients admitted to Beijing Anzhen Hospital with suspected CAD from November 1, 2018, to January 30, 2019, were enrolled. All patients underwent coronary angiography, and an experienced heart team calculated the SYNTAX scores (SXscore) for all available coronary angiograms. BLLs were determined with atomic absorption spectrophotometry and compared between patients with angiographically diagnosed CAD and those without CAD. RESULTS: In total, 343 (76%) patients had CAD, of whom 42% had low (0-22), 22% had intermediate (23-32), and 36% had high (≥ 33) SXscore. BLLs were 36.8 ± 16.95 µg/L in patients with CAD and 31.2 ± 15.75 µg/L in those without CAD (P = 0.003). When BLLs were categorized into three groups (low, middle, high), CAD prevalence increased with increasing BLLs (P < 0.05). In the multivariate regression model, BLLs were associated with CAD (odds ratio (OR): 1.023, 95% confidence interval (CI): 1.008-1.039; P = 0.0017). OR in the high versus low BLL group was 2.36 (95% CI: 1.29-4.42,P = 0.003). Furthermore, BLLs were independently associated with intermediate and high SXscore (adjusted OR: 1.050, 95% CI: 1.036-1.066; P < 0.0001). CONCLUSION: BLLs were significantly associated with angiographically diagnosed CAD. Furthermore, BLLs showed excellent predictive value for SXscore, especially for complex coronary artery lesions.

19.
Ying Yong Sheng Tai Xue Bao ; 32(12): 4447-4456, 2021 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-34951286

RESUMO

With the acceleration of industrialization, the toxic effect of heavy metal cadmium (Cd) pollution has become prominent. In order to explore the molecular mechanism of the physiological regulation of Caulerpa lentillifera under Cd stress, we analyzed the transcriptome of Cd-stressed (Hcd2+) algae tissues using RNA-Seq. A total of 702 differentially expressed genes (DEGs) were screened between the control and Hcd2+ groups, out of which 257 genes were up-regulated and 445 genes were down-regulated in the Hcd2+ group. We conducted functional annotation and enrichment analysis of the obtained DEGs. The results showed that various biological functions of C. lentillifera were affected under Cd2+stress, which eventually showed growth inhibition. Results of GO enrichment analysis showed that the production and removal of reactive oxygen species (ROS) in C. lentillifera were out of balance and caused oxidative damage such as DNA damage. Results of KEGG enrichment analysis showed that many photosynthesis-related pathways were inhibited, indicating that Cd2+ stress led to disorder of photosynthetic reaction of C. lentillifera.


Assuntos
Caulerpa , Metais Pesados , Cádmio/toxicidade , Caulerpa/genética , Perfilação da Expressão Gênica , Metais Pesados/toxicidade , Transcriptoma
20.
Mil Med Res ; 8(1): 60, 2021 11 24.
Artigo em Inglês | MEDLINE | ID: mdl-34819142

RESUMO

BACKGROUND: The burden of kidney, bladder, and prostate cancers has changed in recent decades. This study aims to investigate the global and regional burden of, and attributable risk factors for genitourinary cancers during the past 30 years. METHODS: We extracted data of kidney, bladder, and prostate cancers from the Global Burden of Disease 2019 database, including incidence, mortality, disability-adjusted life-years (DALYs), and attributable risk factors from 1990 to 2019. Estimated annual percentage changes (EAPC) were calculated to assess the changes in age-standardized incidence rate, age-standardized mortality rate (ASMR), and age-standardized DALYs rate (ASDR). The associations between cancers burden and socio-demographic index (SDI) were also analyzed. RESULTS: Compared with 1990, the global incident cases in 2019 were higher by 154.78%, 123.34%, and 169.11% for kidney, bladder, and prostate cancers, respectively. During the 30-year study period, there was a downward trend in ASMR and ASDR for bladder cancer (EAPC = - 0.68 and - 0.83, respectively) and prostate cancer (EAPC = - 0.75 and - 0.71, respectively), but an upward trend for kidney cancer (EAPC = 0.35 and 0.12, respectively). Regions and countries with higher SDI had higher incidence, mortality, and DALYs for all three types of cancers. The burden of bladder and prostate cancers was mainly distributed among older men, whereas the burden of kidney cancer increased among middle-aged men. Smoking related mortality and DALYs decreased, but high body mass index (BMI) and high fasting plasma glucose (FPG) related mortality and DALYs increased among kidney, bladder, and prostate cancers during the study period. CONCLUSIONS: Kidney, bladder, and prostate cancers remain major global public health challenges, but with distinct trend for different disease entity across different regions and socioeconomic status. More proactive intervention strategies, at both the administrative and academic levels, based on the dynamic changes, are needed.


Assuntos
Neoplasias da Próstata , Bexiga Urinária , Idoso , Carga Global da Doença , Humanos , Rim , Masculino , Pessoa de Meia-Idade , Neoplasias da Próstata/epidemiologia , Anos de Vida Ajustados por Qualidade de Vida , Fatores de Risco
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