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1.
Commun Biol ; 4(1): 1034, 2021 08 31.
Artigo em Inglês | MEDLINE | ID: mdl-34465887

RESUMO

COVID-19 has caused numerous infections with diverse clinical symptoms. To identify human genetic variants contributing to the clinical development of COVID-19, we genotyped 1457 (598/859 with severe/mild symptoms) and sequenced 1141 (severe/mild: 474/667) patients of Chinese ancestry. We further incorporated 1401 genotyped and 948 sequenced ancestry-matched population controls, and tested genome-wide association on 1072 severe cases versus 3875 mild or population controls, followed by trans-ethnic meta-analysis with summary statistics of 3199 hospitalized cases and 897,488 population controls from the COVID-19 Host Genetics Initiative. We identified three significant signals outside the well-established 3p21.31 locus: an intronic variant in FOXP4-AS1 (rs1853837, odds ratio OR = 1.28, P = 2.51 × 10-10, allele frequencies in Chinese/European AF = 0.345/0.105), a frameshift insertion in ABO (rs8176719, OR = 1.19, P = 8.98 × 10-9, AF = 0.422/0.395) and a Chinese-specific intronic variant in MEF2B (rs74490654, OR = 8.73, P = 1.22 × 10-8, AF = 0.004/0). These findings highlight an important role of the adaptive immunity and the ABO blood-group system in protection from developing severe COVID-19.


Assuntos
COVID-19/etnologia , COVID-19/genética , Grupos Étnicos/genética , Estudo de Associação Genômica Ampla , Predisposição Genética para Doença/genética , Humanos , Íntrons/genética , Polimorfismo de Nucleotídeo Único
2.
Food Res Int ; 148: 110583, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34507729

RESUMO

Recently protein has gained eminence due to awareness and demand for healthy food. Potato proteins are extracted from potato fruit juice and industrial potato waste; its nutritional and functional values have been found more significant than other vegetables and cereal proteins. Potato proteins can be easily extracted by various separation techniques, including an ion exchange (IEX) and expanded bed adsorption (EBA), and their functional properties can be modified for desire purposes. It contains many essential amino acids necessary for the human body, with an amino acid score (AAS) of 65%. Recent research on potato proteins resulted in several descriptions of new technologies to produce food-grade potato protein. It has recently drawn more attention as a protein source for human consumption, especially as an allergy free protein source and selective activity against cancer cells. Growing shreds of evidence have highlighted that potato protein can be used in many upcoming nutraceuticals and allergy-free food products. Therefore it is gaining more attention from nutritionists and food scientists. This review has summarized the recent knowledge on the nutritional and functional aspects of potato proteins, especially its non-allergic properties, enhancement in functional properties, and possible future-based products.

3.
Curr Med Chem ; 2021 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-34525910

RESUMO

Prolyl-specific peptidases or proteases, including Dipeptidyl Peptidase 2, 4, 6, 8, 9, 10, Fibroblast Activation Protein, prolyl endopeptidase and prolyl carboxypeptidase, belong to the dipeptidyl peptidase family. In human physiology and anatomy, they have homology amino acid sequences, similarities in structure, but play distinct functions and roles. Some of them also play important roles in the metabolism of drugs containing endogenous peptides, xenobiotics containing peptides, and exogenous peptides. The major functions of these peptidases in both the metabolism of human health and bioactive peptides are of significant importance in the development of effective inhibitors to control the metabolism of endogenous bioactive peptides. The structural characteristics, distribution of tissue, endogenous substrates, and biological functions were summarized in this review. Furthermore, the xenobiotics metabolism of the dipeptidyl peptidase family is illustrated. All the evidence and information summarized in this review would be very useful for researchers to extend the understanding of the proteins of these families and offer advice and assistance in physiology and pathology studies.

4.
J Hazard Mater ; 416: 126216, 2021 08 15.
Artigo em Inglês | MEDLINE | ID: mdl-34492973

RESUMO

Thermal treatment of municipal solid waste incineration fly ash (FA) is an effective method to detoxicate FA and produce secondary material with good utilization properties, but the high temperature induced migration of carbon, chlorine, and catalytic metals from FA to flue gases can result in a considerable reformation of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). Herein, two typical fly ashes were thermally cotreated with sewage sludge (SS), respectively, and the decomposition and reformation of PCDD/Fs were systematically investigated. Thermal treatment effectively decomposed PCDD/Fs in all samples to a low level well meeting the reutilization criterion of 50 ng WHO-TEQ g-1. Cleavage of the oxygen bridge was identified as the primary decomposition pathway. Compared to mono-treating FA, cotreating FA with SS resulted in a better CaO-Al2O3-SiO2 ternary system for vitrification and effectively suppressed the reformation of PCDD/Fs in off-gases with inhibition efficiencies up to 96%. Based on the variation of chemical speciation of N, P, and S in SS after thermal treatment, SS appeared to be a S-N-containing inhibitor which passivated catalytic metals to suppress PCDD/Fs synthesis. The better suppression on de novo pathway than on chlorophenol-route identified by monitoring PCDD/F-fingerprints evolution further verified the suppression mechanism of passivating catalytic metals.

5.
Chemosphere ; 287(Pt 1): 131966, 2021 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-34478960

RESUMO

In this work, a novel sludge biochar/Zn-Al layered double hydroxide composite (SL) was synthesized in a facile co-precipitation method, and it was used to simultaneously remove benzotriazole (BTA) and lead ion (Pb(II)). Batch adsorption experiments demonstrated that composites with sludge content of 1.0 g (SL-1.0) had a great adsorption performance for BTA and Pb(II). The maximum adsorption capacities of SL-1.0 for BTA and Pb(II) were 239.6 and 226.1 mg g-1, respectively. There was preferential adsorption of BTA in BTA and Pb(II) binary system. The adsorption mechanism analysis indicated that the BTA and Pb(II) adsorption involved electrostatic attraction and chemical bonding with surface functional groups on SL-1.0. Specifically, hydrogen bonding and π-π interaction were mainly ascribed to BTA adsorption, while complexation with surface function groups dominated Pb(II) adsorption. With the advantages of facile synthesis and excellent adsorption capacity, SL-1.0 possesses great potential for simultaneously removing of BTA and Pb(II) from wastewaters.

6.
Dermatol Ther ; : e15136, 2021 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-34538013

RESUMO

The routine options for onychomycosis are oral, topical, and device-based therapies which are often limited in terms of efficacy and unsatisfactory side effects. Topical agents such as luliconazole, tioconazole, terbinafine, and tazarotene can be more effective when combined with laser therapies. Our aim was to compare the efficacy and satisfaction rates of CO2 laser therapy with topical agents in patients with onychomycosis. PubMed, the Cochrane Library, Embase, and Ovid databases were searched to identify randomized controlled trials (RCTs) evaluating the effects of combined therapies. Selected study data were analyzed for differences expressed as odds ratio (OR) and relative ratio (RR) with 95% confidence intervals (CI) for dichotomous outcomes. Efficacy and satisfaction outcomes were assessed using quantitative methods. Our investigations showed that combined CO2 laser and topical treatments significantly increased efficacy 5.38-fold when compared with topical agents alone (OR 5.38; 95% CI; 3.20-9.04; P < 0.00001), with low heterogeneity observed among studies (I2 = 38%). Mycological clearance comparison rates were also improved by combined treatments. The higher satisfaction of the combined group was assessed by pooled effect (OR 4.56; 95% CI; 2.78-7.49; P < 0.00001). Our evidence suggests combined therapy may exert positive effects and satisfactory safety for patients with moderate to severe onychomycosis, however, optimal combination options and appropriate dosages require more comprehensive RCTs. This article is protected by copyright. All rights reserved.

7.
Adv Colloid Interface Sci ; 296: 102523, 2021 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-34534750

RESUMO

Polymer carbon nitride (CN) has unique structure and electronic properties, making it attractive in photocatalysis fields. However, the photocatalytic efficiency of the pristine CN photocatalyst is still unsatisfactory. In this regard, the introduction of vacancy defects can effectively tune photoelectric properties of CN photocatalyst through tailoring the electronic structure and bandgap engineering. In this review, the effect of vacancy defects on CN is reviewed from the aspects of light absorption, charge separation and surface photoreactivity of CN. Meanwhile, the current progress in the design of vacancy defects with the classified carbon vacancies (CVs), nitrogen vacancies (NVs), amino and cyano groups on CN to boost the photocatalytic performance is summarized. Furthermore, various characterization methods have been summarized and highlighted, including microscopic characterization (SEM, TEM, AFM, HAADF-STEM), spectroscopic characterization (XRD, FTIR, XAFS, XANES, EPR, PAS, XPS, raman spectroscopy, solid-state NMR spectroscopy), elemental analysis, and computational characterization. Finally, the future opportunities and challenges of CN photocatalysts designed with vacancies and defects are proposed to highlight the development direction of this research field.

8.
BMC Ecol Evol ; 21(1): 167, 2021 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-34488635

RESUMO

BACKGROUND: Chinese grass shrimp (Palaemonetes sinensis) is an important species widely distributed throughout China, which is ecologically relevant and possesses ornamental and economic value. These organisms have experienced a sharp decline in population due to overfishing. Therefore interest in P. sinensis aquaculture has risen in an effort to alleviate fishing pressure on wild populations. Therefore, we investigated the genetic diversity and variation of P. sinensis to verify the accuracy of previous research results, as well as to assess the risk of diversity decline in wild populations and provide data for artificial breeding. METHODS: Palaemonetes sinensis specimens from seven locations were collected and their genetic variability was assessed based on mitochondrial COI gene segments. DNA sequence polymorphisms for each population were estimated using DNASP 6.12. The demographic history and genetic variation were evaluated using Arlequin 3.11. At last, the pairwise genetic distance (Ds) values and dendrograms were constructed with the MEGA 11 software package. RESULTS: Our study obtained sequences from 325 individuals, and 41 haplotypes were identified among the populations. The haplotype diversity (Hd) and nucleotide diversity (π) indices ranged from 0.244 ± 0.083 to 0.790 ± 0.048 and from 0.0004 ± 0.0001 to 0.0028 ± 0.0006, respectively. Haplotype network analyses identified haplotype Hap_1 as a potential maternal ancestral haplotype for the studied populations. AMOVA results indicated that genetic variations mainly occurred within populations (73.07%). Moreover, according to the maximum variation among groups (FCT), analysis of molecular variance using the optimal two-group scheme indicated that the maximum variation occurred among groups (53.36%). Neutrality and mismatch distribution tests suggested that P. sinensis underwent a recent population expansion. Consistent with the SAMOVA analysis and haplotype network analyses, the Ds and FST between the population pairs indicated that the JN population was distinctive from the others. CONCLUSIONS: Our study conducted a comprehensive characterization of seven wild P. sinensis populations, and our findings elucidated highly significant differences within populations. The JN population was differentiated from the other six populations, as a result of long-term geographical separation. Overall, the present study provided a valuable basis for the management of genetic resources and a better understanding of the ecology and evolution of this species.

9.
J Agric Food Chem ; 2021 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-34499505

RESUMO

The present study investigated the potential of free radical grafting conjugation of whey protein isolate (WPI) and (-)-epigallocatechin-3-gallate (EGCG), followed by freeze-drying, for the safe delivery of probiotic Lactobacillus acidophilus (LA) upon digestion and in food systems. WPI-EGCG-LA microspheres presented higher encapsulation efficiency (97%) than native WPI-LA (70%) and maltodextrin (MD-LA 75%). The physicochemical characteristics of all microspheres, including moisture content, water activity, and hygroscopicity, were within the acceptable range for the stability of industrial powders. Scanning electron microscopy of WPI-EGCG-LA revealed a glass-like structure, with a smoother and less porous surface area than WPI-LA and MD-LA, as a result of the strong binding affinity between WPIs and EGCG. Particle sizes ranged from 438.4 to 453.3 µm. The structural stability of WPI-EGCG-LA was further confirmed by Fourier transform infrared spectra, which revealed some changes in the protein secondary structure. Thermogravimetric and differential scanning calorimetry analysis showed that WPI-EGCG conjugates had higher thermal stability than native WPIs and MD. Additionally, cells encapsulated in WPI-EGCG conjugates demonstrated higher in vitro survivability and surface hydrophobicity compared to free or WPI- and MD-encapsulated cells. Furthermore, WPI-EGCG-LA microspheres exerted enhanced in vitro antioxidant (78%) and antidiabetic (52%) activities. Finally, the WPI-EGCG conjugates remarkably improved probiotic viability (8.55 ± 0.1 log cfu/g) during 30 days of storage in an apple juice drink of pH (3.2 ± 0.01). Hence, the WPI-EGCG conjugate represents a propitious carrier to enhance probiotic functional properties upon digestion and during storage in low-pH food products.

10.
J Acoust Soc Am ; 150(2): 816, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34470328

RESUMO

Traditional stereophonic acoustic echo cancellation algorithms need to estimate acoustic echo paths from stereo loudspeakers to a microphone, which often suffers from the nonuniqueness problem caused by a high correlation between the two far-end signals of these stereo loudspeakers. Many decorrelation methods have already been proposed to mitigate this problem. However, these methods may reduce the audio quality and/or stereophonic spatial perception. This paper proposes to use a convolutional recurrent network (CRN) to suppress the stereophonic echo components by estimating a nonlinear gain, which is then multiplied by the complex spectrum of the microphone signal to obtain the estimated near-end speech without a decorrelation procedure. The CRN includes an encoder-decoder module and two-layer gated recurrent network module, which can take advantage of the feature extraction capability of the convolutional neural networks and temporal modeling capability of recurrent neural networks simultaneously. The magnitude spectra of the two far-end signals are used as input features directly without any decorrelation preprocessing and, thus, both the audio quality and stereophonic spatial perception can be maintained. The experimental results in both the simulated and real acoustic environments show that the proposed algorithm outperforms traditional algorithms such as the normalized least-mean square and Wiener algorithms, especially in situations of low signal-to-echo ratio and high reverberation time RT60.

11.
Phytomedicine ; 91: 153711, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34450377

RESUMO

BACKGROUND: Gemcitabine (GCB) is a first-line chemotherapeutic drug for pancreatic cancer (PCa). However, the resistance begins developing within weeks of chemotherapy. SPINK1 overexpression enhances resistance to chemotherapy. In a recent study, our laboratory established that the oleanolic acid (OA) derivative, K73-03, had a strong inhibitory effect on a SPINK1 overexpressed PCa cells. PURPOSE: In our current study, we studied the enhancement of GCB inhibitory effect by K73-03, a new novel OA derivative, alone or in combination with GCB on the GCB-resistant PCa cells by mitochondrial damage through regulation of the miR-421/SPINK1. METHODS: We detected the binding between miR-421 and SPINK1-3'-UTR in GCB-resistant PCa cells using Luciferase reporter assays. Cells viability, apoptosis, migration, and mitochondrial damage were investigated. RESULTS: The results demonstrated that the combination of K73-03 and GCB suppressed the growth of AsPC-1 and MIA PaCa-2 cells synergistically, with or without GCB resistance. Mechanistic findings showed that a combination of K73-03 and GCB silences SPINK1 epigenetically by miR-421 up-regulating, which leads to mitochondrial damage and inducing apoptosis in GCB-resistant PCa cells. CONCLUSION: We found an interesting finding that the 73-03 in combination with GCB can improve GCB efficacy and decrease PCa resistance, which induced apoptosis and mitochondrial damage through epigenetic inhibition of SPINK1 transcription by miR-421 up-regulation. This was the first study that used OA derivatives on GCB-resistant PCa cells, so this combined strategy warrants further investigation.

12.
Magn Reson Med ; 2021 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-34435698

RESUMO

PURPOSE: Diffusion MRI provides a valuable tool for imaging tissue microstructure. However, due to the lack of related experimental methods and specially designed phantoms, no experimental study has been conducted yet to quantitatively assess the effects of membrane permeability, intracellular volume fraction (IVF), and intracellular diffusivity on the apparent diffusion coefficient (ADC) obtained from diffusion weighted imaging (DWI), and the effects of membrane permeability on the apparent exchange rate (AXR) obtained from filter exchange imaging (FEXI). METHODS: A series of phantoms with three adjustable parameters was designed to mimic tissue microstructural properties including membrane permeability, IVF, and intracellular diffusivity. Quantitative experiments were conducted to assess the effects of these properties on ADC and AXR. DWI scans were performed to obtain axial and radial ADC values. FEXI scans were performed to obtain AXR values. RESULTS: Axial ADC values range from 1.148 µm2 /ms to 2.157 µm2 /ms, and radial ADC values range from 0.904 µm2 /ms to 2.067 µm2 /ms. Radial ADC decreased with a decrease in fiber permeability. Decreased axial and radial ADC values with increased intra-fiber volume fraction, and increased polyvinylpyrrolidone (PVP) concentration of the intra-fiber space were observed. AXR values range from 2.1 s-1 to 4.9 s-1 . AXR increases with fiber permeability. CONCLUSION: The proposed phantoms can quantitatively evaluate the effects of mimicking tissue microstructural properties on ADC and AXR. This new phantom design provides a potential method for further understanding the biophysical mechanisms underlying the change in ADC and diffusion exchange.

13.
Am J Addict ; 2021 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-34411367

RESUMO

BACKGROUND AND OBJECTIVES: The adverse impact of chronic methamphetamine (MA) use on cognitive function has been described in previous studies, but limited evidence is available for abstinent users from prospective longitudinal studies. The aim of the present study was to assess cognitive function of varying abstinent duration. METHODS: This prospective longitudinal study was conducted with baseline and four follow-up interviews every 6 months over 2 years in 358 MA users in Guangdong province, China. The Montreal Cognitive Assessment (MoCA) was used to measure cognitive function. Generalized estimating equation (GEE) analysis was used to examine within-subjects relationships between abstinence and cognitive consequences over time. RESULTS: The repeated measure analysis of variance showed significant differences in the total MoCA score and all subscale scores (except Orientation) in the 24 months follow-up. The GEE model showed that abstinence from MA in the past 6 months predicted an increase of 0.66 (95% confidence interval [CI] = 0.29 to 1.05, p = .002) in MoCA score changes compared with the nonabstinence MA users. Abstinence in the past 12, 18, and 24 months predicted an increase in MoCA total score changes of 1.25 (95% CI = -0.23 to 2.74), 2.15 (95% CI = -0.79 to 5.09), and 5.28 (95% CI = -2.01 to 12.58), respectively, but none of these was statistically significant. DISCUSSION AND CONCLUSIONS: Cognitive function was potentially improved following 6 months of MA abstinence. SCIENTIFIC SIGNIFICANCE: This study extends prior research by long-term follow-up in big sample MA abstinence users. Findings from study support the need for a comprehensive measure to decrease MA use and promote the recovery of cognitive impairment.

14.
Front Immunol ; 12: 701295, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34394095

RESUMO

The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have been reported in association with COVID-19, but the nature of the impairments was not specified. Here, we report a case of a female patient diagnosed with glaucoma on re-hospitalization for ocular complications two months after being discharged from the hospital upon recovery from COVID-19. Meanwhile, the patient was found re-positive for SARS-CoV-2 in the upper respiratory tract. The infection was also diagnosed in the aqueous humor through immunostaining with antibodies against the N protein and S protein of SARS-CoV-2. Considering the eye is an immune-privileged site, we speculate that SARS-CoV-2 survived in the eye and resulted in the patient testing re-positive for SARS-CoV-2.


Assuntos
Humor Aquoso/virologia , COVID-19/patologia , Glaucoma/patologia , Reinfecção/patologia , Idoso , COVID-19/complicações , Olho/patologia , Olho/virologia , Feminino , Glaucoma/complicações , Humanos , SARS-CoV-2/isolamento & purificação
15.
Artigo em Inglês | MEDLINE | ID: mdl-34363164

RESUMO

The eutrophication of reservoirs can change the physicochemical parameters of water, thus affecting the migration and transformation of heavy metals. At present, there is insufficient research on the coupling mechanisms between nutrients and heavy metals, especially between heavy metals in suspended particles. In this paper, spatial and temporal distribution characteristics of nutrients dissolved heavy metals, and heavy metals in suspended particles were analyzed in a seasonally stratified reservoir. Combined with the nitrogen and phosphorus biogeochemical process, the coupling mechanisms between heavy metals and nutrients were discussed. The results showed that the Aha Reservoir had temperature and dissolved oxygen stratification in April and July. The reduction and dissolution of Fe and Mn oxide/hydroxide and the resuspension of sediments might result in a simultaneous increase in the concentrations of nutrients, dissolved heavy metals and heavy metals in suspended particles in hypolimnion in July and October. In the presence of dissimilatory iron-reducing bacteria (DRIB), the dissolution of iron-bound phosphorus in sediments and suspended particulate matter (SPM) might lead to the simultaneous release of iron and phosphorus into the water. The dissolution of metal sulfides in the sediments and SPM under the action of dissimilatory nitrate reduction to ammonium (DNRA) bacteria might lead to the simultaneous release of ammonia nitrogen and heavy metals into the water. Due to the coupling between nitrogen and phosphorus and heavy metals, seasonal stratified reservoir may face the risk of periodic simultaneous pollution of eutrophication and heavy metals in summer and autumn. This research provides theoretical support for the treatment of heavy metal and eutrophication combined pollution in karst areas.

16.
BMC Res Notes ; 14(1): 300, 2021 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-34353359

RESUMO

OBJECTIVE: The Hedgehog pathway is a fundamental signaling pathway in organogenesis. The expression patterns of the ligand Sonic Hedgehog (Shh) and key pathway components have been studied in many tissues but direct spatial comparisons across tissues with different cell compositions and structural organization are not common and could reveal tissue-specific differences in pathway dynamics. RESULTS: We directly compared the expression characteristics of Shh, and four genes with functional roles in signaling and whose expression levels serve as readouts of pathway activity in multiple tissues of the embryonic mouse head at embryonic day 15.5 by serial in situ hybridization. The four readout genes were the positive feedback regulator Gli1, and three negative feedback regulators, Patched1, Patched2, and Hedgehog Interacting Protein. While the relative abundance of Gli1 was similar across tissues, the relative expression levels and spatial distribution of Shh and the negative feedback regulators differed, suggesting that feedback regulation of hedgehog signaling is context dependent. This comparative analysis offers insight into how consistent pathway activity could be achieved in tissues with different morphologies and characteristics of ligand expression.


Assuntos
Cabeça/embriologia , Proteínas Hedgehog , Transdução de Sinais , Animais , Retroalimentação Fisiológica , Proteínas Hedgehog/genética , Camundongos , Proteína GLI1 em Dedos de Zinco/genética
17.
Arch Gynecol Obstet ; 2021 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-34390384

RESUMO

BACKGROUND: Autoimmune diseases as antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) could cause many maternal complications. The most common maternal complications of autoimmune diseases are lupus flare, hypertension, nephritis, preeclampsia (PE), eclampsia, and poor pregnancy outcomes which including preterm delivery and pregnancy loss. Only the lupus anticoagulant in the greatest prospective multicenter study has been associated with adverse pregnancy outcomes of the APS. PURPOSE: This review aims to provide a comprehensive update for predictors in pregnant women with APS/SLE. METHODS: These data have been collected from clinical and pathological studies, systematic reviews, and meta-analysis. RESULTS: In recent years the SLE and APS demonstrated to have different and valuable clinical and biomarker predictors for the pregnancy outcome. Treatment of pregnant women with APS is low molecular weight heparin (LMWH) and aspirin; however, around 75% of this management is considered successful. CONCLUSION: This review summarizes recent research that focuses on biochemical and clinical predictors of adverse pregnancy outcomes (APOs) of pregnant women with SLE and APS. Furthermore, we have collected more evidence that confirms the safety and efficacy of hydroxychloroquine (HCQ) preventing APOs.

18.
J Agric Food Chem ; 69(35): 10104-10113, 2021 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-34449210

RESUMO

Lipid digestion characteristics in human, bovine, and caprine milk were investigated using an infant in vitro digestion model. Our results suggested that particle size in bovine and caprine milk increased initially and then decreased over time, whereas the particle size in human milk continuously decreased. The lipolysis degree of human milk (86.8%) was higher than that in bovine (80.2%) and caprine (82.7%) milk (P < 0.05). Compared to human milk, bovine and caprine milk released higher unsaturated fatty acids and lower SFAs. In addition, 12 and 84 glyceride species were significantly different between bovine and human milk, during gastrointestinal digestion (P < 0.05). Another 13 and 92 glyceride species were found to be significantly different between caprine and human milk. A total of 30 and 31 lipids were screened as biomarkers to further clarify the differences related to lipid digestion properties of human, bovine, and caprine milk.


Assuntos
Cabras , Leite , Animais , Bovinos , Digestão , Humanos , Lactente , Fórmulas Infantis , Lipídeos , Leite Humano
19.
J Cell Mol Med ; 25(17): 8479-8489, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34346162

RESUMO

Scutellarin, an active flavone extracted from Erigeron breviscapus, is known to exhibit antitumour activity in many cancers. However, the effects of Scutellarin on osteosarcoma remain unclear. In this study, we found that Scutellarin suppressed osteosarcoma cell growth, induced cell apoptosis and inhibited tumorigenesis. Mechanistically, our data revealed that EGR1 was significantly increased under Scutellarin treatment. Increased EGR1 enhanced tumour-suppressive effects of Scutellarin on osteosarcoma cells via transcriptionally downregulating LINC00857 expression. Additionally, we found that LINC00857 acted as a competitive endogenous RNA of miR-150-5p and inhibited the activity of miR-150-5p, which resulted in c-Myc increase. Scutellarin could suppress c-Myc protein levels through decreasing LINC00857 expression in osteosarcoma. Thus, these findings demonstrate that EGR1/ LINC00857/miR-150-5p/c-Myc axis plays a key role in promoting anticancer effects of Scutellarin and Scutellarin might have potential clinical implication in osteosarcoma clinical treatment.

20.
Environ Pollut ; 290: 117991, 2021 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-34428705

RESUMO

Porous carbons are appealing low-cost and metal-free catalysts in persulfate-based advanced oxidation processes. In this study, a family of porous biochar catalysts (ZnBC) with different porous structures and surface functionalities are synthesized using a chemical activation agent (ZnCl2). The functional biochars are used to activate persulfate for sulfamethoxazole (SMX) degradation. ZnBC-3 with the highest content of ketonic group (CO, 1.25 at%) exhibits the best oxidation efficiency, attaining a rate constant (kobs) of 0.025 min-1. The correlation coefficient of the density of CO to kobs (R2 = 0.992) is much higher than the linearity of the organic adsorption capacity to kobs (R2 = 0.694), implying that CO is the intrinsic active site for persulfate activation. Moreover, the volume of mesopore (R2 = 0.987), and Zeta potential (R2 = 0.976) are also positive factors in PS adsorption and catalysis. In the mechanistic study, we identified that singlet oxygen is the primary reactive oxygen species. It can attack the -NH2 group aligned to the benzene ring to form dimer products which could be adsorbed on the biochar surface to reach complete removal of the SMX. The optimal pH range is 4-6 which will minimize the electrostatic repulsion between ZnBCs and the reactants. The SMX degradation in ZnBC/PS system was immune to inorganic anions but would compete with organic impurities in the real wastewater. Finally, the biochar catalysts are filled in hydrogel beads and packed in a flow-through packed-bed column. The continuous system yields a high removal efficiency of over 86% for 8 h without decline, this work provided a simple biochar-based persulfate catalyst for complete antibiotics removal in salty conditions.

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