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1.
Sci Total Environ ; 802: 149909, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34525690

RESUMO

Groundwater of alluvial fan plains is the foremost water source, especially in arid/semiarid regions. Its contaminants are big issues for water supply and public health concern. To reveal the groundwater chemistry, contaminants sources and health threats in alluvial aquifers, 81 groundwaters were collected from a typical alluvial fan plain of northern China for nitrogen, fluoride and major ions analysis. Statistical analysis and hydrochemical diagrams as well as human health risk assessment were performed. Nitrate is widely distributed and 53% of groundwaters exceed the permissible limit with the maximum concentration up to 326 mg/L. The distributions of nitrite, ammonia and fluoride contaminants are sporadic in spatial, and the concentrations of fluoride in groundwaters are slightly beyond the permissible limit of 1 mg/L. The hydrochemical facies shift from HCO3-Ca or Mixed HCO3-Na·Ca type to Mixed Cl-Mg·Ca and ClCa type with the increase of nitrate content. Two factors (Factor-1 and Factor-2) are extracted by factor analysis and account 63% of the total variances. The positive loading of F- and negative loading of NO3- on Factor-2 reveal geogenic and anthropogenic origins, respectively. The significant positive loadings of TDS, TH, SO42-, Cl-, Ca2+, Mg2+ on Factor-1 reveal the governing mechanisms on groundwater chemistry by intermixed sources of geogenic origins and anthropogenic inputs. Hydrogeochemical evolution in the study area is driven by both water-rock interaction and anthropogenic forces. Anthropogenic inputs/influences are the dominated forces increasing groundwater nitrate content and salinity in the piedmont zone and the residential and industrial zone of the southeastern lower parts, and would pose potential non-carcinogenic risks to various populations via oral intake pathway. Rational measures should be taken to protect groundwater quality out of the threats of anthropogenic pollution. The geogenic fluoride in groundwater would threat the health of children through oral pathway and should be also concerned. CAPSULE: The driving forces of groundwater chemistry in alluvial fan plains were revealed using integrated approach of factor analysis and geostatistical modelling.


Assuntos
Água Subterrânea , Poluentes Químicos da Água , Monitoramento Ambiental , Fluoretos/análise , Humanos , Nitratos/análise , Poluentes Químicos da Água/análise
2.
Environ Res ; 204(Pt A): 111919, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-34480949

RESUMO

In this study, we investigated a highly efficient adsorbent that can be recycled from the soil. Walnut shells were used as raw materials to prepare original ecological biochar (OBC), illite modified biochar (IBC), FeCl3 modified biochar (magnetic biochar; MBC), and illite and FeCl3 modified biochar (IMBC), which were tested as low-cost adsorbents. The agents were used to remove metolachlor (MET) from soil. Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, magnetic sensitivity curve analysis, and a series of adsorption experiments were conducted to study the interaction between illite and MBC, and the effect on MET adsorption. Compared with OBC, IMBC had more adsorption sites on the surface. IMBC improved the hole filling effect during the adsorption process. IMBC had more oxygen-containing functional groups and it performed better at removing organic matter through π-π interactions. According to the Langmuir model, the Q0 values for IBC, MBC, and IMBC were 91.74 mg g-1, 107.53 mg g-1, and 129.87 mg g-1, respectively, which were significantly higher than that for OBC (72.99 mg g-1). The response surface model was used to explore the optimal adsorption conditions for IMBC. After three regeneration cycles, the MET adsorption rate with IMBC was still 81.38% and the MET recovery rate was 98.12%. Therefore, IMBC was characterized as an adsorbent with high efficiency, low cost, and good recyclability. In addition, we propose a suitable agricultural system for recovering MBC on site in the field.


Assuntos
Solo , Poluentes Químicos da Água , Acetamidas , Adsorção , Carvão Vegetal , Cinética , Fenômenos Magnéticos , Minerais , Espectroscopia de Infravermelho com Transformada de Fourier , Poluentes Químicos da Água/análise
3.
Research (Wash D C) ; 2021: 9854946, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34877539

RESUMO

Isostructural MOFs with similar crystallographic parameter are easily available for MOF-on-MOF growth and possible to form core-shell structure by isotropic growth. However, due to well-matched cell lattice, selective growth in isostructural MOF heterostructures remains a great challenge for engineering atypical MOF heterostructures. Herein, an anisotropic MOF-on-MOF growth strategy was developed to structure a range of multilayer sandwich-like ZIF-L heterostructures via stacking isostructural ZIF-L-Zn and ZIF-L-Co alternately with three-, five-, seven-, and more layer structures. Moreover, these heterostructures with highly designable feature were fantastic precursors for fabricating derivatives with tunable magnetic and catalytic properties. Such strategy explores a novel way of achieving anisotropic MOF-on-MOF growth between isostructural MOFs and opens up new horizons for regulating the properties by MOF modular assembly in versatile functional nanocomposites.

4.
Nurs Open ; 2021 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-34859610

RESUMO

AIM: This study aims to explore the barriers to self-management of patients with adenomyosis. DESIGN: Phenomenological qualitative methodology. METHODS: Totally, 18 patients with diagnosis of adenomyosis participated in this study. We used purposive sampling for recruitment until data saturation. A qualitative research was conducted using in-depth interviews, which were tape recorded and transcribed verbatim. Colaizzi's method was used to analyse the contents of interviews. RESULTS: This study presented important information about the barriers to self-management of patients with adenomyosis in China. Four themes were identified: "lack of disease knowledge," "challenges and dilemmas of daily life," "multidimensional negative emotions" and "personalized supporting requirements." CONCLUSION: The study provided new insights into the barriers to self-management of patients with adenomyosis, including physical, psychological, daily life and self-image problems, and the patients need emotional and social support, which recommended that professionals should provide authoritative health education and multiple support.

5.
Adv Sci (Weinh) ; : e2104183, 2021 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-34889533

RESUMO

The electrocatalytic nitrogen reduction reaction (NRR) is known as a promising mean of nitrogen fixation to mitigate the energy crisis and facilitate fertilizer production under mild circumstances. For electrocatalytic reactions, the design of efficient catalysts is conducive to reducing activation energy and accelerating lethargic dynamics. Among them, hollow structural materials possess cavities in their structures, which can slack off the escape rate of N2 and reaction intermediates, prolong the residence time of N2 , enrich the reaction intermediates' concentration, and shorten electron transportation path, thereby further enhancing their NRR activity. Here, the basic synthetic strategies of hollow structural materials are introduced first. Then, the recent breakthroughs in hollow structural materials as NRR catalysts are reviewed from the perspective of intrinsic, mesoscopic, and microscopic regulations, aiming to discuss how structures affect and improve the catalytic performance. Finally, the future research directions of hollow structural materials as NRR catalysts are discussed. This review is expected to provide an outlook for optimizing hollow structural NRR catalysts.

6.
Mol Biotechnol ; 2021 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-34846690

RESUMO

TUG1 is an lncRNA that plays a critical role in kidney injury. Our preliminary sequencing analysis showed altered TUG1 expression in both congestive heart failure (CHF) patients and CHF patients complicated with chronic kidney disease (CKD). We then studied the role of TUG1 in these two diseases. We enrolled 120 CHF patients without obvious complications, 60 CHF patients complicated with CKD, and 60 healthy volunteers. TUG1 expression in plasma samples from these participants was determined using RT-qPCR. The diagnostic value of TUG1 for CKD development in CHF patients was evaluated by ROC curve analysis. A 2-year follow-up was performed to detect the correlation between TUG1 expression levels and the development of CKD in CHF. TUG1 was lowly expressed in CHF patients and was further downregulated in CHF patients complicated with progressive CKD. ROC curve analysis showed that plasma TUG1 expression levels could be used to distinguish CHF patients complicated with CKD from CHF patients without CKD and healthy controls. During the 2-year follow-up, high CHF expression levels predicted a low incidence of progressive CKD among CHF patients. With the treatment of progressive CHF + CKD, plasma TUG1 was upregulated. LncRNA-TUG1 downregulation may develop the progressive CKD among patients with CHF.

8.
Eur J Pharmacol ; : 174641, 2021 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-34800465

RESUMO

Atherosclerosis is an inflammatory disease of high lethality associated with endothelial dysfunction. Due to the pathophysiological complexity and our incomplete understanding of the mechanisms for the development and progression of atherosclerosis, effective means for the prevention and treatment of atherosclerosis still need further exploration. This study was designed to investigate the potential effects and underlying mechanisms of aloe-emodin derivative (AED) on atherosclerosis. High fat diet (HFD) treated ApoE-/- mice were used as an animal model of atherosclerosis. Intragastric administration of aloe-emodin (AE) or AED for 12 weeks markedly reduced the atherosclerotic plaque in aorta with decreased plaque area, lipid accumulation, macrophage infiltration, collagen content and metabolic abnormalities. By comparison, AED produced more potent anti-atherosclerosis effects than AE at the same dose. AED enhanced production of autophagy flux in cultured human aortic endothelial cells (HAECs). Moreover, AED increased the expression of activating molecule in Beclin1-regulated autophagy 1 (AMBRA1), a key protein involved in autophagosome formation. Furthermore, knockdown of AMBRA1 blocked the promotion effect of AED on autophagy in HAECs. Taken together, AED facilitates endothelial autophagy via AMBRA1 during the progression of atherosclerosis, suggesting the potential application of this compound for atherosclerosis treatment.

9.
J Adv Nurs ; 2021 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-34812513

RESUMO

AIM: The present study aims to explore the research hot spots, development trends and knowledge structure of dignity in the nursing field. DESIGN: Quantitative and co-word biclustering analysis were used. METHODS: Articles on dignity care published from 01 Jan 2011 to 31 Dec 2020, were retrieved from PubMed. The extracted Medical Subject Headings (MeSH) terms were quantitatively analysed using Bibliographic Item Co-occurrence Matrix Builder software. To determine the hot spots, a biclustering analysis was completed using gCluto1.0 software. A strategic diagram and a social network analysis (SNA) were used to reveal trends in the theme and knowledge structure. RESULTS: In the parameters of the retrieval strategy, a total of 1977 papers were included in the present study. Amongst all the extracted MeSH terms, 27 high-frequency MeSH terms were identified, and the hot spots were grouped into five categories. These were namely dignity in: (1) dementia care, (2) palliative care, (3) older people care, (4) healthcare and (5) clinical nursing. In the strategic diagram, the study of dignity in clinical nursing was active and should become an emerging field of research in the near future. CONCLUSIONS: Based on the co-word biclustering of dignity care over the past 10 years, five hot spots were identified, and it was predicted that research on dignity in clinical nursing would be the main trend in future studies. Amongst the five themes it was interesting to note that dignity in dementia and palliative care are core priorities to which scholars should pay more attention. IMPACT: In recent years, dignity-conserving care has been highly valued, however, there are few relevant bibliometric articles that can be referenced on this topic. The present study was considered to offer novel insights into research on dignity in nursing and could be a reliable reference point for researchers when launching new projects.

10.
Anal Chem ; 93(45): 15049-15057, 2021 11 16.
Artigo em Inglês | MEDLINE | ID: mdl-34726904

RESUMO

We report a low-cost and convenient microchannel resistance (MCR) biosensing platform that uses current signal to report biorecognition. The biorecognition behavior between targets and biometric molecules (antigens, antibodies, or oligonucleotides) immobilized on magnetic beads and polystyrene (PS) microspheres induces a quantitative change in the unreacted PS microspheres. After magnetic separation, the unreacted PS microsphere solution is passed through the microchannel, leading to an obvious blocking effect, resulting in an increase in resistance, which can in turn be measured by monitoring the electric current. Thus, the biorecognition is directly converted into a detectable current signal without any bulky instruments or additional chemical reactions. The MCR biosensing platform is cost-effective and user-friendly with high accuracy. It can be an appropriate analysis technique for point-of-care testing in resource-poor settings.


Assuntos
Técnicas Biossensoriais , Anticorpos , Separação Imunomagnética , Microesferas , Poliestirenos
11.
Comput Biol Chem ; 95: 107586, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34619555

RESUMO

A large collection of studies has shown that the occurrence of cancer is related to the functional dysfunction of the pathways. Identification of cancer-related pathways could help researchers understand the mechanisms of complex diseases well. Whereas, most current signaling pathway analysis methods take no account of the gene interaction variations within pathways. Furthermore, considering that some pathways have connection with two or more cancer types, while some are likely to be cancer-type specific pathways. Identifying cancer-type specific pathways contributes to interpreting the different mechanisms of different cancer types. In this study, we first proposed a pathway analysis method named Pathway Analysis of Intergenic Regulation (PAIGR) to identify pathways with dysregulation between genes and compared the performance of this method with four existing methods on four colorectal cancer (CRC) datasets. The results showed that PAIGR could find cancer-related pathways more accurately. Moreover, in order to explore the relationship between the identified pathways and the cancer type, we constructed a pathway interaction network, in which nodes and edges represented pathways and interactions between pathways respectively. Highly connected pathways were considered to play a central role in an extensive range of biological processes, while sparsely connected pathways are considered to have certain specificity. Our results showed that pathways identified by PAIGR had a low nodal degree (i.e., a few numbers of interactions), which suggested that most of these pathways were cancer-type specific.

12.
Org Lett ; 23(20): 8114-8118, 2021 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-34613746

RESUMO

Commercially available Pd/C can be used as a catalyst for nitro group reductions with only 0.4 mol % Pd loading. The reaction can be performed using either silane as a transfer hydrogenating agent or simply a hydrogen balloon (∼1 atm pressure). With this technology, a series of nitro compounds was reduced to the desired amines in high chemical yields. Both the catalyst and surfactant were recycled several times without loss of reactivity.

13.
Genes Dev ; 35(21-22): 1510-1526, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34593603

RESUMO

Cleavage and polyadenylation factor (CPF/CPSF) is a multiprotein complex essential for mRNA 3' end processing in eukaryotes. It contains an endonuclease that cleaves pre-mRNAs, and a polymerase that adds a poly(A) tail onto the cleaved 3' end. Several CPF subunits, including Fip1, contain intrinsically disordered regions (IDRs). IDRs within multiprotein complexes can be flexible, or can become ordered upon interaction with binding partners. Here, we show that yeast Fip1 anchors the poly(A) polymerase Pap1 onto CPF via an interaction with zinc finger 4 of another CPF subunit, Yth1. We also reconstitute a fully recombinant 850-kDa CPF. By incorporating selectively labeled Fip1 into recombinant CPF, we could study the dynamics of Fip1 within the megadalton complex using nuclear magnetic resonance (NMR) spectroscopy. This reveals that a Fip1 IDR that connects the Yth1- and Pap1-binding sites remains highly dynamic within CPF. Together, our data suggest that Fip1 dynamics within the 3' end processing machinery are required to coordinate cleavage and polyadenylation.

14.
Sensors (Basel) ; 21(19)2021 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-34640859

RESUMO

Constrained by traditional fuel-saving technologies that have almost reached the limit of fuel-saving potential, the difficulty in changing urban congestion, and the low market penetration rate of new energy vehicles, in the short term, eco-driving seems to be an effective way to achieve energy-saving and emissions reduction in the transportation industry. This paper reviews the energy-saving theory and technology of eco-driving, eco-driving capability evaluation, and the practical application of eco-driving, and points out some limitations of previous studies. Specifically, the research on eco-driving theory mostly focuses on a single vehicle in a single scene, and there is a lack of eco-driving research for fleets or regions. In addition, the parameters used to evaluate eco-driving capabilities mainly focus on speed, acceleration, and fuel consumption, but external factors that are not related to the driver will affect these parameters, making the evaluation results unreasonable. Fortunately, vehicle big data and the Internet of Vehicles (V2I) provides an information basis for solving regional eco-driving, and it also provides a data basis for the study of data-driven methods for the fair evaluation of eco-driving. In general, the development of new technologies provides new ideas for solving some problems in the field of eco-driving.


Assuntos
Condução de Veículo , Aceleração , Tecnologia , Transportes
15.
Cancer Nurs ; 2021 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-34560707

RESUMO

BACKGROUND: Fear of cancer recurrence (FCR) is one of the most common and aversive psychological phenomena among cancer survivors. Understanding the independent and potentially modifiable risk factors that contribute toward FCR seen in cancer survivors would inform future interventional trials aimed at reducing this risk. OBJECTIVE: The aim of this study was to provide an evidence synthesis of factors correlated with FCR to inform the development of preventive interventions. METHODS: A literature search was performed of the PsycINFO, EMBASE, and MEDLINE (PubMed) databases. Reports published from inception to 2020 focusing on the correlates of FCR with physical, psychological, and social factors were identified. Authors assessed the studies' risk of bias in accordance with the Standard Quality Assessment Criteria for Quantitative Studies (QualSyst criteria) and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. After extracting data and assessing the quality of the included studies, meta-analysis was conducted using RevMan 5.3 software. RESULTS: Thirty-four articles were included in this study with a total sample of more than 13 000 cancer patients. Fear of cancer recurrence was positively correlated with anxiety, depression, avoidance, chemotherapy, distress, intrusive thoughts, fatigue, rumination, and neuroticism. It was negatively correlated with optimism, age, social support, quality of life, time since diagnosis, well-being, and self-efficacy. CONCLUSIONS: We identified 16 factors that are correlated with FCR, 9 positively correlated with FCR and 7 negatively correlated with FCR. IMPLICATIONS FOR PRACTICE: The findings of this study provide direction for the development of precise interventions for FCR in cancer survivors and lay the foundation for the further construction of an FCR-related nursing theoretical framework.

16.
J Sci Food Agric ; 2021 Sep 26.
Artigo em Inglês | MEDLINE | ID: mdl-34564867

RESUMO

BACKGROUND: Pesticide residues in fruits and vegetables threaten food safety. Cleaning before eating is a usual way to remove pesticide residues, so it is very important to find the most efficient cleaning conditions for public health. However, many previous cleaning studies only focused on a single variable which required a large amount of time manpower and material resources. Plackett-Burman design (PBD) and response surface methodology can avoid the earlier-mentioned problems and have potential in studying the influence and interaction of multiple factors. In this study, the effect of five factors on the removal of triadimefon and boscalid from rape by ultrasonic washing was evaluated through PBD: pH of water, ultrasonic cleaning time, water temperature, initial residual concentration and volume of water. RESULTS: Temperature had a significant effect on the rate of triadimefon removal while the other four factors impacted boscalid removal greatly. A higher temperature was better for the removal rate of triadimefon. Under alkaline environment, when initial residual concentration and cleaning time increased with decreasing water volume, the removal rate of boscalid increased. Furthermore, the interactions among factors were obtained. The regression coefficients of fitting equations about triadimefon and boscalid were 0.9657 and 0.9738, respectively. CONCLUSION: Changing pH of water, cleaning time, water volume and temperature during the washing process of rape through PBD designed experiments represents a valid strategy for improving the removal rate of two pesticides residue. This study provides a reference for ultrasonic cleaning conditions by a sink dishwasher, which has a positive effect on food safety. © 2021 Society of Chemical Industry.

17.
Front Psychol ; 12: 644188, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34526927

RESUMO

Hazardous knee biomechanics, such as excessive knee affordance link with injuries in volleyball spike jumps (SPJs) and can be reconfigured by the enhancement of internal focus. The study aimed to explore the effects of video tasks illustrating a high-level SPJ on knee movement in the volleyball SPJ with 15 elite male volleyball athletes. This study investigated the knee movements in sagittal, coronal, and transverse planes before and after the video task in SPJ using one-dimensional statistical parametric mapping (SPM 1D) and discrete statistics. The SPM 1D indicated a larger knee flexion angle (31.17-73.19%, t = 2.611, and p = 0.012), increased knee flexion moment (19.72-21.38%, t = 0.029, and p = 0.029), and increased knee adduction angular velocity (49.07-62.64%, t = 3.148, and p = 0.004) after video task; alternatively, smaller knee external rotation angular velocity (45.85-49.96%, t = 5.199, and p = 0.017) and vertical ground reaction (vGRF) (3.13-5.94%, t = 4.096, and p = 0.014; 19.83-21.97%, t = 4.096, and p = 0.024) were found after the task. With discrete value statistics, the video task increased the peak of knee flexion angle while decreased the peak of extension moment, flexion moment, abduction moment, external moment, the first peak vGRF, and related loading rate. Conclusions: The results indicate that knee biomechanics in volleyball SPJ positively influenced by the video task. The task has the athletes control the knee movements more actively and improves the original hazardous movement strategies. Therefore, the video task presumably can abate the occurrence of knee injuries in volleyball SPJ. Further validation especially in the exercise effect is needed in the future.

18.
Org Lett ; 23(18): 7205-7208, 2021 09 17.
Artigo em Inglês | MEDLINE | ID: mdl-34472877

RESUMO

Highly valued products resulting from reductive aminations utilizing shelf-stable bisulfite addition compounds of aldehydes can be made under aqueous micellar catalysis conditions. Readily available α-picolineborane serves as the stoichiometric hydride source. Recycling of the aqueous reaction medium is easily accomplished, and several applications to targets in the pharmaceutical industry are documented.

19.
Analyst ; 146(20): 6102-6113, 2021 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-34549740

RESUMO

Unlike the traditional perception in genomic DNA or linear RNA, circular nucleic acids are a class of functional biomolecules with a circular configuration and are often observed in nature. These circular molecules encompass the full spectrum of size and play an important role in organisms, making circular nucleic acids research worthy. Due to the low abundance of most types of circular nucleic acids and the disadvantages of short-read sequencing platforms, accurate and full-length circular nucleic acid sequencing and identification is difficult. In this review, we have provided insights into full-length circular nucleic acid detection methods using long-read sequencing technologies, with a focus on the experimental and bioinformatics strategies to obtain accurate sequences.


Assuntos
Ácidos Nucleicos , Biologia Computacional , Sequenciamento de Nucleotídeos em Larga Escala , Ácidos Nucleicos/genética , RNA/genética , Análise de Sequência de DNA
20.
J Clin Lab Anal ; 35(9): e23932, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34403527

RESUMO

BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is one of the most common malignancy with poor prognosis, and the mortality rate remains high. More than 70% of HCC patients have recurrence within 5 years after treatment. The purpose of this study is to evaluate the prognostic values of serum markers with retrospective data. METHODS: We applied real-world data (RWD) to analyze the prognostic values of six serum markers for HCC patients after treatment, including α-fetoprotein (AFP), α-fetoprotein-L3 (AFP-L3), Golgi protein73 (GP73), alanine aminotransferase (ALT), albumin (ALB), and total bilirubin (TBil). A total of 268 cases were enrolled to analyze recurrence-free survival (RFS), and 104 cases were used to analyze overall survival (OS). RESULTS: Our results demonstrated that patients with higher AFP and AFP-L3 had shorter RFS (p = 0.016 and 0.004), while higher GP73, ALT, and TBil experienced longer RFS (p = 0.000, 0.020, and 0.019). Patients with high-level GP73, ALT, TBil, and low-level ALB had significantly higher mortality rate (p=0.035, 0.008, 0.010, and 0.005). Multivariate analysis revealed that GP73 (HR = 1.548, p = 0.001) and ALT (HR = 1.316, p = 0.046) were identified as independent prognostic factors for RFS, ALB (HR = 0.127, p = 0.007), and ALT (HR = 0.237, p = 0.01) were identified as independent prognostic factors for OS. Subgroups analysis showed that GP73 had better prognostic values than other serum markers in early-stage HCC (p = 0.023). CONCLUSIONS: Our study demonstrates that AFP, AFP-L3, and GP73 can be used as prognostic indicators for predicting the recurrence of HCC, while liver function tests have better survival prediction values. GP73 can act as a promising prognostic marker for early-stage HCC.

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