Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 105
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Oncogenesis ; 9(5): 50, 2020 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-32415090

RESUMO

Aberrant expression of protein arginine methyltransferases (PRMTs) has been implicated in a number of cancers, making PRMTs potential therapeutic targets. But it remains not well understood how PRMTs impact specific oncogenic pathways. We previously identified PRMTs as important regulators of cell growth in neuroblastoma, a deadly childhood tumor of the sympathetic nervous system. Here, we demonstrate a critical role for PRMT1 in neuroblastoma cell survival. PRMT1 depletion decreased the ability of murine neuroblastoma sphere cells to grow and form spheres, and suppressed proliferation and induced apoptosis of human neuroblastoma cells. Mechanistic studies reveal the prosurvival factor, activating transcription factor 5 (ATF5) as a downstream effector of PRMT1-mediated survival signaling. Furthermore, a diamidine class of PRMT1 inhibitors exhibited anti-neuroblastoma efficacy both in vitro and in vivo. Importantly, overexpression of ATF5 rescued cell apoptosis triggered by PRMT1 inhibition genetically or pharmacologically. Taken together, our findings shed new insights into PRMT1 signaling pathway, and provide evidence for PRMT1 as an actionable therapeutic target in neuroblastoma.

2.
BMC Mol Cell Biol ; 21(1): 23, 2020 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-32228440

RESUMO

BACKGROUND: Intervertebral disc degeneration (IDD) is characterized by the loss of nucleus pulposus cells (NPCs) and phenotypic abnormalities. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) are involved in the pathogenesis of IDD. In this study, we aimed to investigate the functional effects of lncRNA MALAT1 on NPCs in IDD and the possible mechanism governing these effects. RESULTS: We validated the decreased expression of MALAT1 in the IDD tissues, which was associated with decreased Collagen II and Aggrecan expression. In vitro, overexpressed MALAT1 could attenuate the effect of IL-1ß on NPC proliferation, apoptosis, and Aggrecan degradation. In vivo, MALAT1 overexpression attenuated the severity of disc degeneration in IDD model rats. Our molecular study further demonstrated that MALAT1 could sponge miR-503, modulate the expression of miR-503, and activate downstream MAPK signaling pathways. The effects of MALAT1 on NPCs were partially reversed/aggregated by miR-503 mimics/inhibitor treatment. CONCLUSION: Our data suggested that the MALAT1-miR-503-MAPK pathway plays a critical role in NPCs, which may be a potential strategy for alleviating IDD.

3.
ACS Appl Mater Interfaces ; 12(5): 5951-5957, 2020 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-31940170

RESUMO

Nickel nitride (Ni3N) is a superior hydrogen evolution reaction (HER) catalyst where the nitrogen source is usually ammonia and the reaction temperature is high during the synthesis process. Herein, we employed an innovative method to obtain three-dimensional porous nickel nitride nanosheets on Ni foam (Ni3N/NF) by transforming Ni(OH)2 nanosheets in N2-H2 glow discharge plasma. The obtained Ni3N/NF displays a high HER activity with a small overpotential of 44 mV and a low Tafel slope of 46 mV dec-1, which is competitive to a Pt/C catalyst. Both the test data and simulation results prove that active ions and radicals in plasma play essential roles in achieving the facile nitridation, as well as building a nanostructured morphology over the Ni3N/NF surface. The unique synthesis method opens new avenues for metal nitrides of HER catalysts and beyond.

4.
Angew Chem Int Ed Engl ; 59(5): 1975-1979, 2020 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-31725173

RESUMO

Phosphorus-rich metal phosphides have very high lithium storage capacities, but they are difficult to prepare. A low-temperature phosphorization method based on Mg reducing PCl3 in ZnCl2 molten salt at 300 °C is developed to synthesize phosphorus-rich CuP2 @C from a Cu-MOF derived Cu@C composite. Abnormal oxidation of Cu by Zn2+ in the molten salt is observed, which leads to the porous honeycomb nanostructure and homogeneously distributed ultrafine CuP2 nanocrystals. The honeycomb CuP2 @C exhibits excellent lithium storage performance with high reversible capacity (1146 mAh g-1 at 0.2 A g-1 ) and superior cycling stability (720 mAh g-1 after 600 cycles at 1.0 A g-1 ), showing the promising application of P-rich metal phosphides in lithium ion batteries.

5.
Stem Cell Reports ; 13(1): 115-131, 2019 07 09.
Artigo em Inglês | MEDLINE | ID: mdl-31204298

RESUMO

EED (embryonic ectoderm development) is a core component of the Polycomb repressive complex 2 (PRC2) which catalyzes the methylation of histone H3 lysine 27 (H3K27) during the process of self-renewal, proliferation, and differentiation of embryonic stem cells. However, its function in the mammalian nervous system remains unexplored. Here, we report that loss of EED in the brain leads to postnatal lethality, impaired neuronal differentiation, and malformation of the dentate gyrus. Overexpression of Sox11, a downstream target of EED through interaction with H3K27me1, restores the neuronal differentiation capacity of EED-ablated neural stem/progenitor cells (NSPCs). Interestingly, downregulation of Cdkn2a, another downstream target of EED which is regulated in an H3K27me3-dependent manner, reverses the proliferation defect of EED-ablated NSPCs. Taken together, these findings established a critical role of EED in the development of hippocampal dentate gyrus, which might shed new light on the molecular mechanism of intellectual disability in patients with EED mutations.

6.
Am J Transl Res ; 11(5): 2843-2854, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31217858

RESUMO

Long noncoding RNAs (lncRNAs) are critical regulators of gene transcription. Our previous results have demonstrated that iron deficiency accelerates intervertebral disc degeneration (IDD) by affecting the stability of the DNA polymerase epsilon (Polε) complex. Here, we discovered that the novel lncRNA lncPolE functions as a negative regulator of Polε. The expression of lncPolE in IDD tissues was upregulated compared to its expression in healthy control tissues, and this was in contrast to the PolE1 expression levels. The increased lncPolE level was significantly correlated with the severity of IDD. Ectopic expression of lncPolE in human nucleus pulposus cells (hNPCs) was able to decrease PolE1 levels and cause apoptosis, while the specific knockdown of lncPolE in primary NP cells (pNPCs) from IDD patients can restore PolE1 levels. Interestingly, iron depletion or supplementation can affect the expression of lncPolE. Further analyses indicated that the downregulation of DNA methylation in the promoter region of lncPolE caused its overexpression. Collectively, our results suggest that the aberrant expression of lncPolE contributes to the pathogenesis of IDD by negatively regulating PolE1 in iron deficient conditions, and this may provide a new avenue to alleviate IDD progression in clinical treatment.

7.
J Bone Miner Metab ; 37(5): 815-824, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30900017

RESUMO

It is increasingly recognized that microRNAs (miRNAs) are a kind of important regulators, which are involved in the pathogenesis and development of various human diseases. However, the underlying effects and mechanism of miR-142-5p on the osteoclast differentiation of bone marrow-derived macrophages (BMMs) have not been elucidated. The aim of the present study is to explore the molecular mechanisms that regulate the osteoclastogenesis of BMMs for providing more efficient methods for treating bone-related diseases. In the present study, BMMs were isolated from rats and cultured. Moreover, receptor activators of NF-kB ligands were used to induce the osteoclast differentiation of BMMs. Furthermore, we analyzed the effects of miR-142-5p mimics/inhibitor on the osteoclastogenesis of BMMs. The results indicated that the downregulation of miR-142-5p inhibited the osteoclastogenesis of BMMs, whereas the overexpression enhanced this process. PTEN was testified to be a direct target of miR-142-5p, and its effects on the osteoclastogenesis were also described. Most importantly, treatment of LY29004 (an inhibitor of the PI3k/Akt pathway) can attenuate miR-142-5p osteoclastogenesis effects, while the inhibition effects of LY29004 on the osteoclastogenesis were abolished by knockdown of FoxO1. Taken together, our findings demonstrated that miR-142-5p promotes the osteoclastogenesis of BMMs through PI3k/Akt/FoxO1 pathway via targeting PTEN.


Assuntos
Diferenciação Celular/genética , Macrófagos/citologia , Macrófagos/metabolismo , MicroRNAs/metabolismo , Osteoclastos/citologia , Transdução de Sinais/efeitos dos fármacos , Animais , Sequência de Bases , Diferenciação Celular/efeitos dos fármacos , Regulação para Baixo/efeitos dos fármacos , Proteína Forkhead Box O1/metabolismo , Humanos , Fator Estimulador de Colônias de Macrófagos/farmacologia , MicroRNAs/genética , Osteoclastos/metabolismo , Osteogênese/efeitos dos fármacos , Osteogênese/genética , PTEN Fosfo-Hidrolase/metabolismo , Fosfatidilinositol 3-Quinases/metabolismo , Proteínas Proto-Oncogênicas c-akt/metabolismo , Ligante RANK/farmacologia , Ratos Sprague-Dawley , Regulação para Cima/genética
8.
Chem Commun (Camb) ; 55(29): 4202-4205, 2019 Apr 04.
Artigo em Inglês | MEDLINE | ID: mdl-30896000

RESUMO

While nickel phosphide is a highly attractive catalyst for the hydrogen evolution reaction, its preparation requires either high temperature or the use of highly toxic PH3 directly or indirectly. Herein, we demonstrate that H2 plasma activated red phosphorus enables the synthesis of self-supported Ni2P nanosheet (Ni2P/NF) arrays on commercial nickel foam from a NiO/NF precursor at only 250 °C. Highly reactive atomic H in the plasma induces dissociation of the P4 molecules, yielding an acid stable electrode with excellent hydrogen evolution activity and good mechanical strength.

9.
J Am Chem Soc ; 140(44): 14799-14806, 2018 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-30351925

RESUMO

Early 3d transition metals are not focal catalytic candidates for many chemical processes because they have strong affinities to O, N, C, or H, etc., which would hinder the conversion of those species to products. Metallic Mn, as a representative, undergoes nitridation under ammonia synthesis conditions forming bulk phase nitride and unfortunately exhibits negligible catalytic activity. Here we show that alkali or alkaline earth metal hydrides (i.e., LiH, NaH, KH, CaH2 and BaH2, AHs for short) promotes the catalytic activity of Mn nitride by orders of magnitude. The sequence of promotion is BaH2 > LiH > KH > CaH2 > NaH, which is different from the order observed in conventional oxide or hydroxide promoters. AHs, featured by bearing negatively charged hydrogen atoms, have chemical potentials in removing N from Mn nitride and thus lead to significant enhancement of N2 activation and subsequent conversion to NH3. Detailed investigations on Mn-LiH catalytic system disclosed that the active phase and kinetic behavior depend strongly on reaction conditions. Based on the understanding of the synergy between AHs and Mn nitride, a strategy in the design and development of early transition metals as effective catalysts for ammonia synthesis and other chemical processes is proposed.

10.
Artigo em Inglês | MEDLINE | ID: mdl-30201921

RESUMO

With the rapid advancement of Web 2.0 technologies, Internet medicine, and mobile healthcare, the influence of the use of patient-oriented Mobile Internet-based Health Services (MIHS) on patient satisfaction and the electronic word-of-mouth (WOM) of health service agencies is becoming the focus of the academic research community. Many large hospitals, including some Internet hospitals, have provided various online healthcare service platforms that enable patients to expediently consult with physicians and obtain healthcare services in an online to offline format. The purpose of this study is to analyze the main mechanisms of how the features and users' experiences of MIHS influenced patient satisfaction and continuous use behaviors of the system to generate additional WOM dissemination behaviors. Based on post-adoption behavior and Expectation Confirmation Model of Information Technology Continuance (ECM-IT), this study conducted an empirical study through data collection from users (patients) from a large hospital providing online healthcare services. A total of 494 pieces of data were collected and analyzed using SmartPLS2.0(SmartPLS GmbH, Hamburg, Gernmany). The results show that: (1) patient satisfaction with MIHS and their intentions to continue use of MIHS have significantly positive influences on WOM; (2) patient satisfaction with MIHS is positively influenced by perceived usefulness and confirmation of MIHS performance expectations; (3) and patient intentions to continue use of MIHS are also affected by some technology factors, such as facilitating conditions and perceived risk, as well as some subjective feelings, such as perceived usefulness and perceived interactivity. The results of this study provide important implications for both research and practice of public health.


Assuntos
Satisfação do Paciente , Telemedicina , Adulto , Serviços de Saúde , Humanos , Intenção , Internet , Masculino , Pessoa de Meia-Idade , Médicos , Inquéritos e Questionários
11.
Artigo em Inglês | MEDLINE | ID: mdl-30223469

RESUMO

With the broadening application of the New Rural Cooperative Medical Scheme (NCMS), its role in patient satisfaction in rural China has shifted to be the focus of academic research. Based on a technology acceptance model, this study will investigate the factors and mechanisms influencing patient satisfaction on NCMSS in rural places in China. In this study, based on a technology acceptance model, we developed a model that is associated with the influencing factors, patients' continued participation and patient satisfaction, and conducted an empirical analysis based on data collected from rural areas of China's Anhui Province. A NCMS's reputed reliability, value, and convenience played a key role in positively influencing patient satisfaction. However, long-term patient participation was not significantly influenced by other social factors. In order to increase patient satisfaction, NCMS policy and implementation procedure needs further government modification and innovation with the goal of improving the reimbursement ratio, reducing the financial burden, and improving patient convenience.


Assuntos
Satisfação do Paciente/estatística & dados numéricos , Serviços de Saúde Rural/estatística & dados numéricos , Adolescente , Adulto , China , Feminino , Humanos , Seguro Saúde , Masculino , Pessoa de Meia-Idade , População Rural , Adulto Jovem
12.
Angew Chem Int Ed Engl ; 57(32): 10187-10191, 2018 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-29920895

RESUMO

A mild phosphorization process in low-temperature molten salt (NaCl-KCl-AlCl3 ) has been developed to synthesize peapod-like CoP@C nanostructures by using low-toxicity industrial PCl3 as the phosphorus source and Mg as the reductant at 250 °C. Importantly, high efficiency of the phosphorous source is achieved since only stoichiometric PCl3 is required to complete the reaction. The molten NaCl-KCl-AlCl3 not only provides a liquid environment but also participates in the electron transport by the reversible conversion of the Al3+ /Al redox couple. The obtained 0D-in-1D peapod CoP@C structure exhibits excellent lithium storage performance, delivering a superiorly stable capacity of 500 mAh g-1 after 800 cycles at a high current of 1.0 A g-1 .

13.
Am J Transl Res ; 10(11): 3430-3442, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30662597

RESUMO

Iron serves as an important cofactor of iron-containing proteins that play critical roles in the maintenance of DNA stability and cell cycle progression. The disturbed iron homeostasis results in the pathogenesis of many diseases such as cancer and anemia. In this study, we found a clear correlation between iron deficiency and intervertebral disc degeneration (IDD). Through microarray experiments, we found that a large number of genes were differentially expressed in tissues with different degrees of degeneration. Among them, an iron-containing gene, PolE, the catalytic subunit of DNA polymerase epsilon (Polε), and the other two Polε subunits, including PolE2 and PolE3, were markedly downregulated, while some proteins involved in apoptosis such as Caspase-3 and -8 were significantly upregulated. By supplementation with an iron chelator deferoxamine (DFO) or knocking down either iron divalentmetal transporter 1 (DMT1) or transferrin receptor 1 (TfR1) in the nucleus pulposus (NP) cells, we found that the protein levels of PolE complex members were dramatically reduced, whereas the intrinsic apoptotic pathway was activated. Interestingly, overexpression of PolE in NP cells knocked down with either DMT1 or TfR could not reverse the stability of PolE complex and apoptosis status. In summary, our study suggests that iron deficiency is an important factor in the aggravation of IDD. Proper iron supplementation may be an effective strategy to alleviate the symptoms of patients with IDD.

14.
Angew Chem Int Ed Engl ; 57(8): 2219-2223, 2018 02 19.
Artigo em Inglês | MEDLINE | ID: mdl-29271571

RESUMO

The hydrolysis reaction of aluminum can be decoupled into a battery by pairing an Al foil with a Pd-capped yttrium dihydride (YH2 -Pd) electrode. This hydrolysis battery generates a voltage around 0.45 V and leads to hydrogen absorption into the YH2 layer. This represents a new hydrogen absorption mechanism featuring electrical energy generation during hydrogen absorption. The hydrolysis battery converts 8-15 % of the thermal energy of the hydrolysis reaction into usable electrical energy, leading to much higher energy efficiency compared to that of direct hydrolysis.

15.
Int J Biol Macromol ; 109: 1344-1354, 2018 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-29199123

RESUMO

Sulfated modification was conducted to modify a homogenous polysaccharide from blackcurrant (BCP). The sulfated polysaccharides (SBCPs) with different degree of substitution (DS) were synthesized using the aminosulfonic acid (ASA)/4-dimethylaminopyridine method by varying reaction conditions such as the mass ratio of ASA to BCP, temperature, and time. Three sulfated derivatives were chosen for high-performance gel-permeation chromatography, gas chromatography, fourier-transform infrared (FT-IR) spectroscopy, and nuclear magnetic resonance (NMR), and activity studies, designated as SBCP-1, SBCP-2, and SBCP-3 with DS of 1.28, 0.95, and 0.53, respectively. Results showed that the sulfated modification was successful, and SBCPs had an increase in molecular weight compared to BCP. Both SBCPs and BCP were composed of rhamnose, arabinose, xylose, mannose, galactose, and glucose, with different molar ratios. Sulfate substitution was further confirmed by FT-IR and 13C NMR analysis. SBCPs exhibited excellent antioxidant capacities (DPPH, hydroxyl, and superoxide radical scavenging, reducing power, and ferrous metal-chelating capacities) and α-amylase inhibitory activity in vitro, and the activities of SBCPs were significantly improved in positive correlation with the DS value. This study suggested that SBCPs could serve as potential antioxidant agents to be used as alternative supplements or functional foods.


Assuntos
Antioxidantes/química , Antioxidantes/farmacologia , Polissacarídeos/química , Polissacarídeos/farmacologia , Ribes/química , alfa-Amilases/química , Antioxidantes/isolamento & purificação , Cromatografia Gasosa , Ativação Enzimática/efeitos dos fármacos , Espectroscopia de Ressonância Magnética , Metais/química , Metais/metabolismo , Peso Molecular , Monossacarídeos/química , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/farmacologia , Polissacarídeos/isolamento & purificação , Espectroscopia de Infravermelho com Transformada de Fourier , Temperatura , alfa-Amilases/antagonistas & inibidores
16.
Adv Mater ; 30(3)2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29205533

RESUMO

The lithium storage capacity of graphite can be significantly promoted by rare earth trihydrides (REH3 , RE = Y, La, and Gd) through a synergetic mechanism. High reversible capacity of 720 mA h g-1 after 250 cycles is achieved in YH3 -graphite nanocomposite, far exceeding the total contribution from the individual components and the effect of ball milling. Comparative study on LaH3 -graphite and GdH3 -graphite composites suggests that the enhancement factor is 3.1-3.4 Li per active H in REH3 , almost independent of the RE metal, which is evident of a hydrogen-enhanced lithium storage mechanism. Theoretical calculation suggests that the active H from REH3 can enhance the Li+ binding to the graphene layer by introducing negatively charged sites, leading to energetically favorable lithiation up to a composition Li5 C16 H instead of LiC6 for conventional graphite anode.

17.
Mol Med Rep ; 17(2): 2479-2487, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29207192

RESUMO

Reactive oxygen species (ROS) are implicated in the pathogenesis of thrombosis. Studies have reported that resveratrol exhibits antioxidative activities, however, the effect and underlying mechanisms of resveratrol on venous thrombosis remain largely unknown. To investigate the effect of resveratrol on venous thrombosis and the underlying mechanisms, the present study investigated the effects of resveratrol on cell viability, apoptosis, ROS generation and the expression of thrombosis­associated markers in human umbilical vein endothelial cells (HUVECs). HUVECs were pretreated with resveratrol for 2 h and incubated with hydrogen peroxide (H2O2) for 24 h prior to the evaluation of cell viability, ROS generation, apoptosis and thrombosis­associated marker expression by performing MTT assays, 2',7'­dichlorofluorescin diacetate reagent, flow cytometry, and reverse transcription­quantitative polymerase chain reaction (RT­qPCR) and western blot analysis, respectively. Subsequently, to validate whether resve-ratrol functions via mitogen­activated protein kinase (MAPK) pathways, the expression of thrombosis­associated markers was detected by western blot analysis and RT­qPCR following treatment of cells with resveratrol and the MAPK pathway activators anisomycin and curcumin. The results demonstrated that cell viability was markedly reduced by H2O2, and resveratrol treatment reversed the reductions in cell viability in a dose­dependent manner. In addition, the levels of cell apoptosis and ROS generation were significantly increased by H2O2 alone, and resveratrol also reduced these effects in a dose­dependent manner. Furthermore, the mRNA and protein expression of caspase­3, P­selectin glycoprotein ligand­1 and von Willebrand factor was upregulated by H2O2 treatment in HUVECs. However, resveratrol decreased the protein expression these proteins in a dose­dependent manner. Resveratrol also significantly inhibited the induction of phosphorylated (p)­p38, P­c­Jun N­terminal kinase and P­extracellular signal­regulated kinase by H2O2, and these effects were attenuated by the MAPK pathway activators anisomycin and curcumin. In conclusion, these results indicate that resveratrol protected HUVECs against oxidative stress and apoptosis. Furthermore, to the best of our knowledge, the present study is the first to demonstrate that resveratrol attenuates the expression of thrombosis­associated markers induced by H2O2, which may occur through the suppression of the MAPK signalling pathways, indicating a potential novel therapeutic approach to prevent venous thrombosis.


Assuntos
Antioxidantes/farmacologia , Apoptose/efeitos dos fármacos , Peróxido de Hidrogênio/farmacologia , Sistema de Sinalização das MAP Quinases/efeitos dos fármacos , Glicoproteínas de Membrana/metabolismo , Espécies Reativas de Oxigênio/metabolismo , Estilbenos/farmacologia , Fator de von Willebrand/metabolismo , Caspase 3/metabolismo , Sobrevivência Celular/efeitos dos fármacos , Células Cultivadas , Células Endoteliais da Veia Umbilical Humana , Humanos , Estresse Oxidativo/efeitos dos fármacos , Resveratrol
18.
Food Chem ; 243: 26-35, 2018 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-29146337

RESUMO

In this study, the degradation of polysaccharides from blackcurrant (BCP) was investigated. Two low-molecular-weight polysaccharides (DBCP-1, DBCP-2) were obtained using Fe2+ with different concentrations of H2O2 solution. IR spectra showed DBCPs had obvious characteristic peaks of polysaccharides. GC analysis confirmed DBCPs were composed of the same monosaccharide units as BCP but with different molar ratios. NMR analysis indicated DBCPs and BCP had similar glycosidic linkage patterns. The surface area of fragmented structure in DBCPs was reduced compared to BCP, and they had no triple helix structure. The results of bioactivity assays indicated that DBCPs exhibited higher antioxidant, α-amylase and α-glucosidase inhibitory activities than BCP, and the degraded polysaccharides with the lower molecular weight possessed higher bioactivities. These results suggested that Fe2+-H2O2 degradation did not change the main structure of polysaccharide and the degree of degradation could play a key role in the bioactivities of the polysaccharides.


Assuntos
Antioxidantes/química , Hipoglicemiantes/química , Extratos Vegetais/química , Polissacarídeos/química , Ribes/química , Frutas/química , Peróxido de Hidrogênio/química , Cinética , Peso Molecular , alfa-Amilases/antagonistas & inibidores , alfa-Amilases/química
20.
Adv Sci (Weinh) ; 4(9): 1600257, 2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-28932654

RESUMO

A facile hydrogenation-induced self-assembly strategy to synthesize lithium hydride (LiH) nanosheets with a thickness of 2 nm that are uniformly distributed on graphene is reported and designed. Taking advantage of LiH nanosheets with high reactivity and a homogeneous distribution on graphene support as a nanoreactor, the confined chemical synthesis of oxygen-free lithiated composites is effectively and efficiently realized.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA