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1.
Toxicol Res (Camb) ; 10(5): 1022-1033, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34733487

RESUMO

N, N-Dimethylformamide (DMF) can cause liver damage in occupationally exposed workers, but the molecular mechanism of DMF-induced liver damage has not been fully elucidated. Researches have proved that lncRNA plays a major function in chemical-induced liver toxicity and can be used as a biomarker and therapeutic target for liver injury. In order to verify that lncRNA also participates in DMF-induced liver damage, we treated HL-7702 cells with 75 or 150 mM DMF, and obtained lncRNA expression profiles through high-throughput sequencing. Among the differentially expressed lncRNAs, lncRNA SNHG12 was proved to be significantly downregulated in DMF-treated HL-7702 cells and participate in DMF-mediated apoptosis, even under long-term low-dose DMF exposure (5-10 mM, 8 weeks). In addition, according to bioinformatics analysis, miR-218-5p is expected to be a potential target of SNHG12, which was verified by the dual luciferase reporter assay in HEK293FT cells. MiR-218-5p mimic can induce apoptosis in HL-7702 cells. Among the predicted targets of miR-218-5p, protein kinase C epsilon (PRKCE) was reported to be involved in apoptosis, and was indeed downregulated by miR-218-5p mimic in our study. Further experiments showed that changes of the expression of SNHG12 can affect the expression of PRKCE. In the epidemiological study of occupational population, we also found that SNHG12 was downregulated in the serum exosomes of workers exposed to DMF. These results indicated that SNHG12 can mediate DMF-induced apoptosis of HL-7702 cells through miR-218-5p/PRKCE pathway.

2.
Adv Sci (Weinh) ; : e2103964, 2021 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-34821481

RESUMO

Soluble redox mediators (RMs), an alternative to conventional solid catalysts, have been considered an effective countermeasure to ameliorate sluggish kinetics in the cathode of a lithium-oxygen battery recently. Nevertheless, the high mobility of RMs leads to serious redox shuttling, which induces an undesired lithium-metal degeneration and RM decomposition during trade-off catalysis against the sustainable operation of batteries. Here, a novel carbon family of graphdiyne matrix is first proposed to decouple the charge-carrying redox property of ferrocene and the shuttle effects. It is demonstrated that a ferrocene-anchored graphdiyne framework can function as stationary RM, not only preserving the redox-mediating capability of ferrocene, but also promoting the local orientated three-dimensional (3D) growth of Li2 O2 . As a result, the RM-assisted catalysis in lithium-oxygen battery remains of remarkable efficiency and stability without the depletion of oxidized RMs or lithium degradation, resulting in a significantly enhanced electrochemical performance.

3.
Front Aging Neurosci ; 13: 724990, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34720990

RESUMO

Background: Elevated plasma total homocysteine (tHcy) level, a known risk factor for vascular disease, is reported to be an independent risk factor for cognitive impairment and Alzheimer's disease (AD) in most studies. tHcy may also be associated with dementia with Lewy bodies (DLB). Objective: To investigate the association between plasma tHcy levels and DLB or AD. Methods: This is a case-control study including 132 DLB patients, 264 AD patients, and 295 age-matched healthy controls. We used multivariate logistic regression model to analyze the data with adjustments for confounding variables. Results: The highest tHcy tertile (>13.9 µmol/L) was significantly independently associated with DLB [adjusted odds ratio (OR): 4.65, 95% confidence interval (CI): 1.95-11.10, P = 0.001] and AD (adjusted OR: 1.82, 95% CI: 1.02-3.23, P = 0.041) compared to the lowest tertile (<10.7 µmol/L). The cumulative frequency plots showed a shift in the distribution of the tHcy concentrations to higher values in patients with DLB compared to AD. The mean tHcy levels were stable and not altered by the duration of cognitive impairment prior to the collection of blood samples from DLB patients. Conclusion: Elevated plasma tHcy levels were independently associated with DLB, and the association was stronger for DLB than for AD. The lack of a relationship between tHcy levels and symptom duration may refute these observed associations being a consequence of DLB, and future longitudinal studies will be required to confirm whether tHcy plays a causative role in DLB.

4.
J Spine Surg ; 7(3): 269-276, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34734131

RESUMO

Background: Osteoporosis is a prevalent disease that predisposes patients to fracture and additional post-operative complications, potentially contributing to decreased quality of life. The objective of the current study is to (I) characterize the demographic trends of individuals with osteoporosis undergoing single level posterior spine instrumentation and fusion (PSIF) and anterior lumbar interbody fusion (ALIF); (II) determine the association between osteoporosis and postoperative complications; (III) identify whether the use of bone strengthening medications is associated with improved outcomes. Methods: A retrospective review of the Mariner Claims Database was conducted on patients undergoing single level ALIF (CPT 22558) and PSIF (CPT 22840) between 2011 and 2017. Diagnosis of osteoporosis (CPT 77080, CPT 77801, CPT 77082) included a bone density scan within two years of surgery. Patients with osteoporosis were 1:1 matched to controls. Patients taking bone enhancing medications prior to surgery were compared to those that did not take medications. Multivariable logistic regression analyses were performed to evaluate post-operative complication risk factors. Results: 3,502 patients with diagnosed osteoporosis underwent ALIF and PSIF, of which 788 (22.5%) were treated with supplemental medication. Diagnosis of osteoporosis was associated with an increased risk of pulmonary embolism [1.1% vs. 0.4%, odds ratio (OR) 2.48, 95% confidence interval (CI): 1.36-4.53, P=0.003] and minor complications (16.7% vs. 12.9%, OR 1.15, 95% CI: 1.01-1.30, P=0.039). Revision rates two-years post-operatively were not significantly different between patients with osteoporosis and matched controls (P>0.05). There were no differences in outcomes between osteoporotic patients who received medications and those who did not receive medication (P>0.05). Conclusions: Osteoporosis is common in a nationally-representative Medicare database cohort. Pre-operative diagnosis of osteoporosis is associated with increased minor complications following ALIF and PSIF. Pre-operative osteoporosis treatment is not associated with a significant difference in post-operative outcomes. The current study can guide pre-operative counseling in this cohort.

6.
Neoplasma ; 2021 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-34641697

RESUMO

We conducted a prospective study to evaluate the efficacy and safety of cladribine, cytarabine, mitoxantrone, and granulocyte colony-stimulating factor (CLAG-M) regimen combined with busulfan and cyclophosphamide (Bucy) as new intensive conditioning before allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of relapsed/refractory acute myeloid leukemia (AML). 24 patients were enrolled. The median follow-up was 15.2 months (range 1.9-67.0 months). Except for one patient who died before graft infusion, the evaluable 23 patients (96%) achieved complete remission (CR). The two-year overall survival (OS) rate and leukemia-free survival (LFS) rate were 61.4% and 59.4%, respectively. The non-relapse mortality (NRM) was 9.1%. Univariate analysis revealed that the myeloid blast phase of chronic myelomonocytic leukemia (CMML), an EVI1 mutated, blood blasts ≥ 20% at transplant and extramedullary disease were risk factors for LFS.

7.
China CDC Wkly ; 3(16): 335-339, 2021 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-34594879

RESUMO

What is already known about this topic?: OA has been listed as the fastest increasing major public health problem and ranked second as a cause of disability by World Health Organization (WHO). With population aging, osteoarthritis (OA) is causing an increased economic burden for individuals and society and is attracting an increasing amount of scientific attention. What is added by this report?: This research used healthcare data to analyze the epidemiological characteristics of OA in Yichang City, Hubei Province, China. The exact number and distribution of patients were obtained, and a descriptive analysis of OA visits by age, gender, and season was performed. Knee joint disease among women was most common, followed by other joint diseases. Knee osteoarthritis was the most common OA diagnosis between 60 and 69 years of age. What are the implications for public health practice?: In China, the prevalence of OA among middle-age and elderly people was high. With increases in the size of the elderly population, the burden of disease caused by OA may increase. It is necessary to strengthen publicity to improve people's awareness of self-health care of bone and joint. Interventions and preventive strategies targeting high-risk groups are urgently needed in order to improve healthy bones and healthy life quality among middle-age and elderly people.

8.
Opt Express ; 29(19): 30543-30557, 2021 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-34614777

RESUMO

Three-dimensional (3D) shape measurement with fringe projection technique and vertical scanning setup can alleviate the problem of shadow and occlusion. However, the shape-from-defocus based method suffers from limited sensitivity and low signal-to-noise ratio (SNR), whereas the projection-triangulation based is sensitive to the zero-phase detection. In this paper, we propose paraxial 3D shape measurement using parallel single-pixel imaging (PSI). The depth is encoded in the radial distance to the projector optical center, which is determined by the projection of light transport coefficients (LTCs). The third-order polynomial fitting is used for depth mapping and calibration. Experiments on 5 objects with different materials and textures are conducted, and standards are measured to test the accuracy. The results verified that the proposed method can achieve robust, dense reconstruction with depth accuracy at 20 µm while the root-mean-square error (RMSE) of plane fitting up to 43 µm.

9.
Opt Express ; 29(16): 25032-25047, 2021 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-34614844

RESUMO

We present a compressive parallel single-pixel imaging (cPSI) method, which applies compressive sensing in the context of PSI, to achieve highly efficient light transport coefficients capture and 3D reconstruction in the presence of strong interreflections. A characteristic-based sampling strategy is introduced that has sampling frequencies with high energy and high probability. The characteristic-based sampling strategy is compared with various state-of-the-art sampling strategies, including the square, circular, uniform random, and distance-based sampling strategies. Experimental results demonstrate that the characteristic-based sampling strategy exhibits the best performance, and cPSI can obtain highly accurate 3D shape data in the presence of strong interreflections with high efficiency.

10.
Opt Express ; 29(16): 26150-26164, 2021 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-34614927

RESUMO

Interreflections introduced by points in a scene are not only illuminated by the light source used but also by other points in the scene. Interreflections cause inaccuracy and the failure of 3D recovery and optical measurements. In this research, a novel method for separating interreflections through parallel single-pixel imaging (PSI) is proposed, which can decompose interreflections into 1st bounce light, 2nd bounce light, and a higher order light component. PSI is used in obtaining the light transport coefficients of each camera pixel, and light transport coefficients are used in decomposing the intensity distribution of a projector and the component of interreflections. Results show that the proposed method can separate the interreflections of a real static scene in a concave surface.

11.
Opt Express ; 29(20): 32220-32227, 2021 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-34615298

RESUMO

In this paper, a methodology to produce a multi-beam sub-nanosecond laser is proposed. Laser pulses with a pulse energy of 0.14 mJ and a pulse width of 490 ps are generated in a YAG/Nd:YAG/Cr4+:YAG microchip laser at a repetition rate of 200 Hz. After amplification with a laser diode (LD) side-pumped Nd:YAG module, four laser beams are generated because of the thermally induced birefringence. With a double-pass LD side-pumped amplifier, the single pulse energy of the four laser beams is amplified to 5.23 mJ with a peak power of ∼10.67 MW, and air breakdown with four points is achieved with a 2 × 2 lens array.

12.
Food Chem Toxicol ; 158: 112592, 2021 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-34624416

RESUMO

Di-(2-ethylhexyl) phthalate (DEHP) is a typical endocrine-disrupting chemical (EDC) that can increase the risk of central nervous system disease. This study aimed to investigate the in vitro and in vivo effects of DEHP exposure on GDNF secretion and the underlying mechanisms. Pregnant Wistar rats were randomly assigned into four groups and administered 0, 30, 300, or 750 mg/kg DEHP daily by oral gavage. In addition, primary astrocytes were exposed to mono-(2-ethylhexyl) phthalate (MEHP), the main metabolite of DEHP. Our results showed that DEHP exposure reduced GDNF levels and downregulated the ERK/c-fos signaling pathway in the cerebral cortex of male, but not female, offspring. Moreover, exogenous estrogen could overcome the decreased GDNF levels in astrocytes caused by MEHP exposure. MEHP also decreased p300 levels and downregulated the ERK/c-fos signaling pathway in primary astrocytes. Honokiol restored GDNF levels following MEHP exposure by activating the ERK/c-fos signaling pathway, while the inhibitor U0126 further reduced the GDNF levels. These results suggested that DEHP exposure could interfere with the normal effects of estrogen in the brain and downregulate the ERK/c-fos signaling pathway to decrease the GDNF secretion from astrocytes in the cerebral cortex.

13.
Spine J ; 2021 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-34718176

RESUMO

BACKGROUND CONTEXT: Macrophages play important roles in the progression of intervertebral disc herniation and radiculopathy. PURPOSE: To better understand the roles of macrophages in this process, we developed a new mouse model that mimics human radiculopathy. STUDY DESIGN/SETTING: A preclinical randomized animal study. METHODS: Three types of surgeries were performed in randomly assigned Balb/c mice. These were spinal nerve exposure, traditional anterior disc puncture, and lateral disc puncture with nerve exposure (n=16/group). For the nerve exposure group, the left L5 spinal nerve was exposed without disc injury. For the traditional anterior puncture, L5/6 disc was punctured by an anterior approach as previously established. For lateral puncture with nerve exposure, the left L5 spinal nerve was exposed by removing the psoas major muscle fibers, and the L5/6 disc was punctured laterally on the left side with a 30G needle, allowing the nucleus to protrude toward the L5 spinal nerve. Mechanical hyperalgesia (pain sensitivity) of hind paws was assessed with electronic von Frey assay on alternative day for up to 2 weeks. MRI, histology, and immunostaining were performed to confirm disc herniation and inflammation. RESULTS: Ipsilateral pain in the lateral puncture with nerve exposure group was significantly greater than the other groups. Pro-inflammatory cytokines IL-1ß and IL-6 were markedly elevated at the hernia sites of both puncture groups and the spinal nerve of lateral puncture with never exposure group on postoperative day 7. Heterogeneous populations of macrophages were detected in the infiltration tissue of this mouse model and in tissue from patients undergone discectomy. CONCLUSIONS: We have established a new mouse model that mimics human radiculopathy and demonstrated that a mixed phenotype of macrophages contribute to the pathogenesis of acute discogenic radiculopathy. CLINICAL SIGNIFICANCE: This study provides a clinically relevant in vivo animal model to elucidate complex interactions of disc herniation and radicular pain, which may present opportunities for the development of macrophage-anchored therapeutics to manage radiculopathy.

14.
Biomed Res Int ; 2021: 9591177, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34671680

RESUMO

Objective: This study was designed to probe into the changes and clinical significance of GRP78 and miR-495-3p in renal failure (RF) patients during high-flux dialysis (HFD) combined with hemoperfusion (HP). Methods: Sixty-five RF patients and 74 health check-ups who were admitted in our hospital from March 2015 to February 2017 were prospectively selected, and the related characteristics were retrospectively collected for analysis. GRP78 and miR-495-3p were detected in RF patients at admission (before treatment), 12 weeks after treatment (during treatment), 24 weeks after treatment (after treatment), and the control group at admission, and the relationship between the two and the occurrence, efficacy, and recurrence of RF was analyzed. Results: Before treatment, the GRP78 mRNA level in RF patients was higher than that in health check-ups, while the miR-495-3p level was lower (P < 0.05). GRP78 mRNA in RF patients was lower than that before treatment and was the lowest after treatment. On the contrary, miR-495-3p was higher than that before treatment and was the highest after treatment (P < 0.05). The two had a significant effect on predicting RF before treatment, efficacy of patients, and their recurrence after treatment (all P < 0.001). Conclusion: GRP78 decreased during the treatment of high-flux hemodialysis (HF-HD) combined with systemic HP in RF patients, while miR-495-3p increased. Both of them have a good reference value for RF occurrence, treatment results, and recurrence.

15.
Parasit Vectors ; 14(1): 452, 2021 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-34488869

RESUMO

BACKGROUND: Despite the medical importance of mosquitoes of the genus Anopheles in the transmission of malaria and other human diseases, its phylogenetic relationships are not settled, and the characteristics of mitochondrial genome (mitogenome) are not thoroughly understood. METHODS: The present study sequenced and analyzed the complete mitogenomes of An. peditaeniatus and An. nitidus, investigated genome characteristics, and inferred the phylogenetic relationships of 76 Anopheles spp. RESULTS: The complete mitogenomes of An. peditaeniatus and An. nitidus are 15,416 and 15,418 bp long, respectively, and both include 13 PCGs, 22 tRNAs, two tRNAs and one control region (CR). Mitogenomes of Anopheles spp. are similar to those of other insects in general characteristics; however, the trnR and trnA have been reversed to "trnR-trnA," as has been reported in other mosquito genera. Genome variations mainly occur in CR length (493-886 bp) with six repeat unit types identified for the first time that demonstrate an evolutionary signal. The subgenera Lophopodomyia, Stethomyia, Kerteszia, Nyssorhynchus, Anopheles and Cellia are inferred to be monophyletic, and the phylogenetic analyses support a new phylogenetic relationship among the six subgenera investigated, in that subgenus Lophopodomyia is the sister to all other five subgenera, and the remaining five subgenera are divided into two clades, one of which is a sister-taxon subgenera Stethomyia + Kerteszia, and the other consists of subgenus Nyssorhynchus as the sister to a sister-group subgenera Anopheles + Cellia. Four series (Neomyzomyia, Pyretophorus, Neocellia and Myzomyia) of the subgenus Cellia, and two series (Arribalzagia and Myzorhynchus) of the subgenus Anopheles were found to be monophyletic, whereas three sections (Myzorhynchella, Argyritarsis and Albimanus) and their subdivisions of the subgenus Nyssorhynchus were polyphyletic or paraphyletic. CONCLUSIONS: The study comprehensively uncovered the characteristics of mitogenome and the phylogenetics based on mitogenomes in the genus Anopheles, and provided information for further study on the mitogenomes, phylogenetics and taxonomic revision of the genus.

16.
Math Biosci Eng ; 18(5): 5995-6011, 2021 07 02.
Artigo em Inglês | MEDLINE | ID: mdl-34517520

RESUMO

The traditional signature-based detection method requires detailed manual analysis to extract the signatures of malicious samples, and requires a large number of manual markers to maintain the signature library, which brings a great time and resource costs, and makes it difficult to adapt to the rapid generation and mutation of malware. Methods based on traditional machine learning often require a lot of time and resources in sample labeling, which results in a sufficient inventory of unlabeled samples but not directly usable. In view of these issues, this paper proposes an effective malware classification framework based on malware visualization and semi-supervised learning. This framework includes mainly three parts: malware visualization, feature extraction, and classification algorithm. Firstly, binary files are processed directly through visual methods, without assembly, decompression, and decryption; Then the global and local features of the gray image are extracted, and the visual image features extracted are fused on the whole by a special feature fusion method to eliminate the exclusion between different feature variables. Finally, an improved collaborative learning algorithm is proposed to continuously train and optimize the classifier by introducing features of inexpensive unlabeled samples. The proposed framework was evaluated over two extensively researched benchmark datasets, i.e., Malimg and Microsoft. The results show that compared with traditional machine learning algorithms, the improved collaborative learning algorithm can not only reduce the cost of sample labeling but also can continuously improve the model performance through the input of unlabeled samples, thereby achieving higher classification accuracy.


Assuntos
Algoritmos , Aprendizado de Máquina Supervisionado , Aprendizado de Máquina
18.
Eur J Pharm Sci ; 167: 106004, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-34520834

RESUMO

Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)-based molecular targeted therapy are proved to be effective in the treatment of non-small cell lung cancer (NSCLC) with EGFR mutation, its efficacy is limited by the acquired drug resistance. The combination of EGFR-TKIs with photodynamic therapy (PDT) has been explored to combat NSCLC with promising synergistic results. However, hypoxic tumor microenvironment is associated with the development of EGFR-TKIs resistance and severely limits the efficacy of PDT. Here, we synthesized an aptamer modified fluorinated dendrimer (APF) as a drug carrier and prepared nanocomplexes APFHG by encapsulation of gefitinib (Gef) and hematoporphyrin (Hp). APF has good oxygen-carrying capacity, high drug entrapment efficiency, and could release Gef and Hp in response to intracellular pH. APF can specifically recognize EGFR-positive NSCLC cells and effectively improve the tumor hypoxic microenvironment due to the targeting effect of aptamer and the good oxygen-carrying capacity of the fluorinated dendrimer. Under the laser irradiation, APFHG can significantly increase the production of the intracellular reactive oxygen species and produce a synergistic therapeutic effect in inhibition of cellular growth and induction of cell cycle arrest and apoptosis on both Gef-sensitive and Gef-resistant EGFR-mutant NSCLC cells through PDT/molecular targeted therapy. This work indicates that fluorinated dendrimer could be a potent drug delivery platform to overcome hypoxia-related resistance and the co-delivery of EGFR-TKI and photosensitizer by the fluorinated dendrimer could be a promising therapeutic approach for reversal of EGFR-TKIs resistance in EGFR mutation-positive NSCLC.


Assuntos
Antineoplásicos , Carcinoma Pulmonar de Células não Pequenas , Dendrímeros , Neoplasias Pulmonares , Fotoquimioterapia , Antineoplásicos/farmacologia , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Linhagem Celular Tumoral , Dendrímeros/farmacologia , Resistencia a Medicamentos Antineoplásicos , Receptores ErbB/genética , Gefitinibe/farmacologia , Gefitinibe/uso terapêutico , Hematoporfirinas/farmacologia , Hematoporfirinas/uso terapêutico , Humanos , Hipóxia , Neoplasias Pulmonares/tratamento farmacológico , Mutação , Inibidores de Proteínas Quinases/farmacologia , Microambiente Tumoral
19.
Oxid Med Cell Longev ; 2021: 1622375, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34367460

RESUMO

Saccharomyces boulardii (S. boulardii) is a probiotic yeast that is widely used to treat gastrointestinal disorders. The present study is aimed to explore the therapeutic effects of S. boulardii on dextran sulfate sodium- (DSS-) induced murine ulcerative colitis (UC) and illustrate the mechanisms of action. C57BL/6 mice were administered S. boulardii (105 and 107 CFU/ml, p.o.) for 3 weeks and then given DSS [2.5% (w/v)] for one week. Administration of S. boulardii prevented DSS-induced reduction in body weight, diarrhea, bloody feces, decreased colon length, and loss of histological structure. Moreover, S. boulardii protected the intestinal barrier by increasing the levels of tight junction proteins zona occludens-1 and Occludin and exerted immunomodulatory effects in DSS-induced mice. Furthermore, S. boulardii suppressed the colonic inflammation by reducing the levels of Interleukin-1ß, Interleukin-6, and Tumor necrosis factor alpha and restored myeloperoxidase activity in mice exposed to DSS. S. boulardii also mitigated colonic oxidative damage by increasing the levels of antioxidant enzymes (superoxide dismutase, catalase, and heme oxygenase 1) and glutathione and decreasing malondialdehyde accumulation. Further studies identified that S. boulardii suppressed the nuclear translocation of nuclear factor kappa B (NF-κB) p65 subunit by decreasing IκKα/ß levels, while promoted the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in DSS-exposed mice. Collectively, S. boulardii possessed an appreciable therapeutic effect against the experimental mice model of UC. The protective mechanism of S. boulardii may involve inhibition of NF-κB-mediated proinflammatory signaling and activation of Nrf2-modulated antioxidant defense in addition to intestinal barrier protective and immunomodulatory effects.

20.
Front Psychiatry ; 12: 685965, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34335331

RESUMO

Objectives: Cerebral small vessel disease (CSVD) is the most common vascular cause of dementia, and mild cognitive impairment (MCI) is an intermediate state between dementia and normal cognitive aging. The present study investigated the main imaging features of CSVD on different MCI subtypes in memory clinics. Methods: A total of 236 patients with MCI and 85 healthy controls were included. One hundred nine amnestic MCI-multiple domains (amMCI), 38 amnestic MCI-single domain (asMCI), 36 non-amnestic MCI-multiple domains (namMCI), and 53 non-amnestic MCI-single domain (nasMCI) patients were diagnosed. All participants were evaluated with the cognitive assessments and imaging features including white matter hyperintensity (WMH), enlarged perivascular spaces (EPVS), cerebral microbleeds (CMBs), and cerebral atrophy according to a standard procedure. Results: The patients with amMCI, namMCI, and nasMCI had more high-grade basal ganglia EPVS compared with healthy controls, while the percentages of high-grade basal ganglia EPVS in the patients with amMCI were also more than those in patients with asMCI, namMCI, and nasMCI. There were more high-grade centrum semiovale EPVS in patients with amMCI in comparison with all other groups. The patients with amMCI and namMCI had more percentages of severe deep and periventricular WMH and deep CMBs compared with healthy controls. All MCI groups had higher scores of the medial temporal lobe atrophy than healthy controls, whereas the scores of the amMCI group were also higher than those of the namMCI and nasMCI groups. Conclusions: There were varied neuroimaging features of CSVD including cerebral atrophy in different MCI groups, which meant that vascular mechanism contributed to the prodromal stage of dementia.

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