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1.
J Int Med Res ; 49(7): 3000605211032859, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34334002

RESUMO

Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting inflammatory disorder of unknown etiology and pathogenesis. This report presents a rare case involving a man with 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) hypermetabolism caused by KFD mimicking malignant lymphoma. The PET/CT maximum intensity projection showed multiple hypermetabolic lymphadenopathies and homogeneous FDG uptake in the bone marrow and spleen. Malignant lymphoma was initially suspected. The patient then underwent excision biopsy of one enlarged right cervical lymph node that was selected because it showed the highest FDG uptake in PET/CT, and examination of this biopsy specimen confirmed the diagnosis of KFD. PET/CT is useful for assessing the general condition of patients and can help to select lymph nodes for excision biopsy based on the highest FDG uptake. However, KFD can predispose to localized FDG uptake and limit the specificity of PET/CT by mimicking malignancy. Thus, positive results of PET/CT should be interpreted with caution.


Assuntos
Linfadenite Histiocítica Necrosante , Linfoma , Fluordesoxiglucose F18 , Linfadenite Histiocítica Necrosante/diagnóstico por imagem , Humanos , Linfonodos/diagnóstico por imagem , Linfoma/diagnóstico por imagem , Masculino , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Tomografia por Emissão de Pósitrons
2.
BMJ Open ; 11(6): e044313, 2021 06 08.
Artigo em Inglês | MEDLINE | ID: mdl-34103313

RESUMO

OBJECTIVES: This study aimed to explore the diagnostic significance of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT for predicting the presence of epidermal growth factor receptor (EGFR) mutations in patients with non-small cell lung cancer (NSCLC). DESIGN: A systematic review and meta-analysis. DATA SOURCES: The PubMed, EMBASE and Cochrane library databases were searched from the earliest available date to December 2020. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: The review included primary studies that compared the mean maximum of standard uptake value (SUVmax) between wild-type and mutant EGFR, and evaluated the diagnostic value of 18F-FDG PET/CT using SUVmax for prediction of EGFR status in patients with NSCLC. DATA EXTRACTION AND SYNTHESIS: The main analysis was to assess the sensitivity and specificity, the positive diagnostic likelihood ratio (DLR+) and DLR-, as well as the diagnostic OR (DOR) of SUVmax in prediction of EGFR mutations. Each data point of the summary receiver operator characteristic (SROC) graph was derived from a separate study. A random effects model was used for statistical analysis of the data, and then diagnostic performance for prediction was further assessed. RESULTS: Across 15 studies (3574 patients), the pooled sensitivity for 18F-FDG PET/CT was 0.70 (95% CI 0.60 to 0.79) with a pooled specificity of 0.59 (95% CI 0.52 to 0.66). The overall DLR+ was 1.74 (95% CI 1.49 to 2.03) and DLR- was 0.50 (95% CI 0.38 to 0.65). The pooled DOR was 3.50 (95% CI 2.37 to 5.17). The area under the SROC curve was 0.68 (95% CI 0.64 to 0.72). The likelihood ratio scatter plot based on average sensitivity and specificity was in the lower right quadrant. CONCLUSION: Meta-analysis results showed 18F-FDG PET/CT had low pooled sensitivity and specificity. The low DOR and the likelihood ratio scatter plot indicated that 18F-FDG PET/CT should be used with caution when predicting EGFR mutations in patients with NSCLC.


Assuntos
Carcinoma Pulmonar de Células não Pequenas , Neoplasias Pulmonares , Carcinoma Pulmonar de Células não Pequenas/diagnóstico por imagem , Carcinoma Pulmonar de Células não Pequenas/genética , Receptores ErbB/genética , Fluordesoxiglucose F18 , Humanos , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/genética , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Tomografia por Emissão de Pósitrons , Compostos Radiofarmacêuticos , Sensibilidade e Especificidade
3.
Chempluschem ; 86(5): 700-708, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33755353

RESUMO

The advent of crescent-shaped Y6 and its derivatives have recently enabled exceptionally high solar cell performance metrics, for structural, physical, and transport characteristics that remain poorly understood. Here we summarize recent progress on crystallography, electronic structure, and device performance of this kind of non-fullerene acceptors. First, we discuss molecular engineering and the crystal structure of Y6 and its derivatives. Second, we present theoretical modeling of the molecular orbitals, reorganization energy, and electronic couplings. Third, we summarize single carrier diode and solar cell performance, and discuss the correlations between crystal structure and computational insights. Finally, we discuss unsolved problems and future developments in this field. Overall, this Minireview summarizes crystal structure, computational understanding, and device metrics, thus providing an outlook for future organic semiconductors design and mechanistic studies in fundamental research and industrial applications.

4.
Ann Nucl Med ; 35(2): 139-147, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33460010

RESUMO

Alzheimer's disease (AD) is on the rise all over the world, and brings with it great challenges to medical care and heavy burdens to family and society. Accurate diagnosis and differential diagnosis are of great importance. Tau positron emission tomography (PET) might offer novel insights and be of great assistance in monitoring disease progression and supporting the differential diagnosis. 18F-AV-1451, as the first Tau PET imaging agent approved by the Food and Drug Administration (FDA), has been of great potential in clinical trials. Here, we reviewed the synthesis and characteristics of 18F-AV-1451 and its role in monitoring AD progression and supporting the differential diagnosis.


Assuntos
Doença de Alzheimer/diagnóstico por imagem , Carbolinas/química , Meios de Contraste/química , Tomografia por Emissão de Pósitrons/métodos , Proteínas tau/análise , Encéfalo/metabolismo , Diagnóstico Diferencial , Progressão da Doença , Aprovação de Drogas , Humanos , Estados Unidos , United States Food and Drug Administration
5.
Transl Oncol ; 14(1): 100920, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33137541

RESUMO

Regulated by the tumor microenvironment, the metabolic network of the tumor is reprogrammed, driven by oncogenes and tumor suppressor genes. The metabolic phenotype of tumors of different driven-genes and different tissue types is extremely heterogeneous. KRAS-mutant non-small cell lung cancer (NSCLC) has glutamine dependence. In this study, we demonstrated that glutamine utilization of KRAS-mutant NSCLC was higher than that of KRAS wild-type. CB839, an efficient glutaminase inhibitor, synergized with the MEK inhibitor selumetinib to enhance antitumor activity in KRAS-mutant NSCLC cells and xenografts, and the therapeutic response could be well identified by 18F-FDG PET imaging. Combination therapy induced redox stress, manifesting as a decrease in mitochondrial membrane potential and an increase in ROS levels, and energetic stress manifesting as suppression of glycolysis and glutamine degradation. The phosphorylation of AKT was also suppressed. These effects combined to induce autophagy and thereby caused cancer cell death. Our results suggest that dual inhibition of the MEK-ERK pathway and glutamine metabolism activated by KRAS mutation may be an effective treatment strategy for KRAS-driven NSCLC.

6.
Clin Med (Lond) ; 20(5): 449-453, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32934036

RESUMO

BACKGROUND: This study investigated the clinical significance of 18F-fluorodeoxyglucose positron emission tomography / computed tomography (18F-FDG PET/CT) in identifying the causes of fever of unknown origin (FUO). METHODS: Patients with a fever who received an 18F-FDG PET/CT examination were retrospectively selected. The means of the two groups were compared using an independent-samples t-test. RESULTS: Among the 89 included patients, 66 were diagnosed using 18F-FDG PET/CT. The sensitivity, specificity and diagnostic accuracy of 18F-FDG PET/CT for the diagnosis of patients with FUO were 84.5%, 25.8%, and 64.0%, respectively. The detection rates of 18F-FDG PET/CT for neoplastic diseases, infectious diseases and non-infectious inflammatory diseases were 100%, 61.3%, and 75%, respectively. The difference in C-reactive protein (CRP) levels between the two groups was statistically significant. CONCLUSIONS: 18F-FDG PET/CT has great clinical importance in diagnosing and identifying causes of FUO and improves the accuracy of FUO diagnosis when combined with serum CRP levels.


Assuntos
Febre de Causa Desconhecida , Fluordesoxiglucose F18 , Febre de Causa Desconhecida/diagnóstico por imagem , Febre de Causa Desconhecida/etiologia , Humanos , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Tomografia por Emissão de Pósitrons , Estudos Retrospectivos
7.
Cancer Manag Res ; 12: 6385-6395, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32801879

RESUMO

Purpose: This study aimed to evaluate the role of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) in expression of tumor programmed death ligand-1 (PD-L1) expression and prognostic significance of 18F-FDG PET/CT at different PD-L1 status in patients with lung adenocarcinoma. Patients and Methods: Seventy-three patients with primary lung adenocarcinoma who received 18F-FDG PET/CT before treatment were retrospectively included in this study. Expression of tumor PD-L1, programmed death-1 (PD-1) and glucose metabolic parameters were evaluated. Results: Tumor PD-L1 expression was positively correlated with maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG), hexokinase II (HK-II) and glucose transporter 1 (GLUT-1) (P<0.0001 for all). SUVmax was a unique independent predictor of tumor PD-L1 expression, with an optimal cut-off value of 9.5. For all the patients, tumor stage (P<0.001) and SUVmax (P=0.009) were independent prognostic indicators of disease-free survival (DFS)/progression-free survival (PFS) while carcino-embryonic antigen (CEA) (P=0.003), Ki67 (P=0.042), PD-L1 (P=0.048) and TLG (P=0.004) were independent prognostic indicators of overall survival (OS). Tumor stage (P=0.004) and SUVmax (P=0.022) were independent prognostic indicators of DFS/PFS while TLG (P=0.012) and CEA (P=0.045) were independent prognostic indicators of OS in the PD-L1-positive group. In the PD-L1-negative group, tumor stage (P=0.002) and CEA (P=0.006) were unique independent prognostic indicators of DFS/PFS and OS, respectively. Conclusion: 18F-FDG PET/CT may potentially predict tumor PD-L1 expression and play a role in predicting prognosis of PD-L1/PD-1 immunotherapy in lung adenocarcinoma.

8.
Ann Nucl Med ; 34(5): 369-376, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32086761

RESUMO

To further promote the clinical application of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in infection and inflammation and standardize the diagnostic process, the experts in relevant fields in China carried out discussion and formed the Expert Consensus on the clinical application of FDG PET/CT in infection and inflammation. This consensus is intended to provide a reference for imaging physicians to select a reasonable diagnostic plan. However, it should be noted that it couldn't include or solve all the problems in clinical operation. Imaging physicians and technicians should develop a comprehensive and reasonable diagnostic procedure according to their professional knowledge, clinical experience and currently available medical resources when facing specific patients.


Assuntos
Consenso , Prova Pericial/estatística & dados numéricos , Fluordesoxiglucose F18 , Infecções/diagnóstico por imagem , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Humanos , Processamento de Imagem Assistida por Computador , Inflamação/diagnóstico por imagem
9.
Cancer Imaging ; 19(1): 56, 2019 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-31420006

RESUMO

OBJECTIVE: Lung cancer usually presents as a solitary pulmonary nodule (SPN) on diagnostic imaging during the early stages of the disease. Since the early diagnosis of lung cancer is very important for treatment, the accurate diagnosis of SPNs has much importance. The aim of this study was to evaluate the discriminant power of dual time point imaging (DTPI) PET/CT in the differentiation of malignant and benign FDG-avid solitary pulmonary nodules by using neighborhood gray-tone difference matrix (NGTDM) texture features. METHODS: Retrospective analysis was carried out on 116 patients with SPNs (35 benign and 81 malignant) who had DTPI 18F-FDG PET/CT between January 2005 and May 2015. Both PET and CT images were acquired at 1 h and 3 h after injection. The SUVmax and NGTDM texture features (coarseness, contrast, and busyness) of each nodule were calculated on dual time point images. Patients were randomly divided into training and validation datasets. Receiver operating characteristic (ROC) curve analysis was performed on all texture features in the training dataset to calculate the optimal threshold for differentiating malignant SPNs from benign SPNs. For all the lesions in the testing dataset, two visual interpretation scores were determined by two nuclear medicine physicians based on the PET/CT images with and without reference to the texture features. RESULTS: In the training dataset, the AUCs of delayed busyness, delayed coarseness, early busyness, and early SUVmax were 0.87, 0.85, 0.75 and 0.75, respectively. In the validation dataset, the AUCs of visual interpretations with and without texture features were 0.89 and 0.80, respectively. CONCLUSION: Compared to SUVmax or visual interpretation, NGTDM texture features derived from DTPI PET/CT images can be used as good predictors of SPN malignancy. Improvement in discriminating benign from malignant nodules using SUVmax and visual interpretation can be achieved by adding busyness extracted from delayed PET/CT images.


Assuntos
Neoplasias Pulmonares/diagnóstico por imagem , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos , Nódulo Pulmonar Solitário/diagnóstico por imagem , Idoso , Feminino , Fluordesoxiglucose F18 , Humanos , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Compostos Radiofarmacêuticos , Sensibilidade e Especificidade , Nódulo Pulmonar Solitário/patologia
10.
Clin Lung Cancer ; 20(6): 420-428, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31300363

RESUMO

PURPOSE: To study the prognostic significance of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) metabolic parameters and tumor galectin-1 (Gal-1) expression in patients surgically treated for lung adenocarcinoma. PATIENTS AND METHODS: The medical records of 96 patients with primary lung adenocarcinoma who underwent surgery after 18F-FDG PET/CT were retrospectively reviewed. The maximal standardized uptake value (SUVmax), metabolic tumor volume, and total lesion glycolysis of the primary tumor were measured through PET/CT imaging. The expression of tumor Gal-1, glucose transporter 1 (GLUT-1), and hexokinase II (HK-II) were examined through immunohistochemistry. RESULTS: There were significant positive correlations between tumor Gal-1 and SUVmax, tumor Gal-1 and metabolic tumor volume, tumor Gal-1 and total lesion glycolysis, tumor Gal-1 and GLUT-1 expression, tumor Gal-1 and HK-II expression, and SUVmax and tumor GLUT-1 and HK-II expression (P < .0001 in all cases). SUVmax was the only independent predictor of tumor Gal-1 expression. On receiver operating characteristic analysis, the optimal cutoff value of SUVmax for predicting tumor Gal-1 expression was 5.1. Progression-free and overall survival were significantly shorter in patients with Gal-1-positive tumors than in those with Gal-1-negative tumors (P ≤ .001). On multivariate analysis, advanced tumor stage (P = .001) and tumor Gal-1 expression (P < .0001) were independent prognostic indicators of poor progression-free survival, while advanced tumor stage (P < .0001) and SUVmax (P = .024) were independent prognostic indicators of poor overall survival. CONCLUSION: 18F-FDG PET/CT has the potential to be used as a noninvasive imaging modality to assess tumor Gal-1 status and prognosis in lung adenocarcinoma.


Assuntos
Adenocarcinoma de Pulmão/diagnóstico , Galectina 1/metabolismo , Neoplasias Pulmonares/diagnóstico , Tomografia por Emissão de Pósitrons/métodos , Adenocarcinoma de Pulmão/mortalidade , Idoso , Diagnóstico por Imagem , Feminino , Fluordesoxiglucose F18/metabolismo , Regulação Neoplásica da Expressão Gênica , Transportador de Glucose Tipo 1/metabolismo , Hexoquinase/metabolismo , Humanos , Neoplasias Pulmonares/mortalidade , Masculino , Pessoa de Meia-Idade , Pneumonectomia , Prognóstico , Estudos Retrospectivos , Análise de Sobrevida
11.
Cancer Med ; 8(11): 5341-5351, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31355526

RESUMO

Subunit of isocitrate dehydrogenase 3 (IDH3a) as upstream of the hypoxia-inducible factor was reported highly expressed in malignant tumors, playing an important role in glucose metabolism reprogramming. As one of rate-limiting enzyme in the Krebs cycle, whether high expression of IDH3a affects glucose uptake in tumors has not been elucidated. This study was aimed to investigate the relationship between IDH3a expression and tumor glucose uptake. Sixty-five patients who underwent 2-[18 F]-2-deoxy-D-glucose ([18 F]-FDG) positron emission tomography/computed tomography (PET/CT) imaging before surgery and pathologically diagnosed as lung adenocarcinoma were included. All patients were divided into high (n = 31) and low (n = 34) groups according IDH3a expression by immunohistochemistry. Comparatively higher [18 F]-FDG uptake was found in high IDH3a expression group. Glucose transporter 1 (GLUT1) level was demonstrated to correlate with IDH3a expression, but not for hexokinase 2 (HK2). Furthermore, A549 and H1299 cells experiment showed, the expression of p-AKT and GLUT1 were significantly downregulated after IDH3a interference. The cellular uptake of [18 F]-FDG and lactate production were significantly reduced in treatment group. In summary, high expression of IDH3a in lung adenocarcinoma patients is associated with higher glucose uptake. IDH3a targets AKT-GLUT1 pathway to affect glucose uptake and metabolites in lung adenocarcinoma.


Assuntos
Adenocarcinoma de Pulmão/metabolismo , Glucose/metabolismo , Isocitrato Desidrogenase/metabolismo , Adenocarcinoma de Pulmão/diagnóstico por imagem , Adenocarcinoma de Pulmão/genética , Idoso , Transporte Biológico , Biomarcadores , Linhagem Celular Tumoral , Feminino , Fluordesoxiglucose F18/metabolismo , Expressão Gênica , Transportador de Glucose Tipo 1/genética , Transportador de Glucose Tipo 1/metabolismo , Humanos , Imuno-Histoquímica , Isocitrato Desidrogenase/genética , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
12.
BMB Rep ; 52(7): 457-462, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31186081

RESUMO

[18F]Fluorodeoxyglucose (FDG) PET/CT imaging has been widely used in the diagnosis of malignant tumors. ATPase family AAA domain-containing protein 2 (ATAD2) plays important roles in tumor growth, invasion and metastasis. However, the relationship between [18F]FDG accumulation and ATAD2 expression remains largely unknown. This study aimed to investigate the correlation between ATAD2 expression and [18F]FDG uptake in lung adenocarcinoma (LUAD), and elucidate its underlying molecular mechanisms. The results showed that ATAD2 expression was positively correlated with maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG), glucose transporter type 1 (GLUT1) expression and hexokinase2 (HK2) expression in LUAD tissues. In addition, ATAD2 knockdown significantly inhibited the proliferation, tumorigenicity, migration, [18F]FDG uptake and lactate production of LUAD cells, while, ATAD2 overexpression exhibited the opposite effects. Furthermore, ATAD2 modulated the glycometabolism of LUAD via AKT-GLUT1/HK2 pathway, as assessed using LY294002 (an inhibitor of PI3K/AKT pathway). In summary, to explore the correlation between ATAD2 expression and glycometabolism is expected to bring good news for anti-energy metabolism therapy of cancers. [BMB Reports 2019; 52(7): 457-462].


Assuntos
ATPases Associadas a Diversas Atividades Celulares/metabolismo , Adenocarcinoma de Pulmão/metabolismo , Proteínas de Ligação a DNA/metabolismo , Fluordesoxiglucose F18/farmacocinética , Neoplasias Pulmonares/metabolismo , ATPases Associadas a Diversas Atividades Celulares/antagonistas & inibidores , ATPases Associadas a Diversas Atividades Celulares/genética , Adenocarcinoma de Pulmão/tratamento farmacológico , Adenocarcinoma de Pulmão/patologia , Movimento Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Células Cultivadas , Cromonas/farmacologia , Proteínas de Ligação a DNA/antagonistas & inibidores , Proteínas de Ligação a DNA/genética , Relação Dose-Resposta a Droga , Feminino , Transportador de Glucose Tipo 1/antagonistas & inibidores , Transportador de Glucose Tipo 1/metabolismo , Hexoquinase/antagonistas & inibidores , Hexoquinase/metabolismo , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Morfolinas/farmacologia , Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores , Proteínas Proto-Oncogênicas c-akt/metabolismo
13.
Cancer Manag Res ; 11: 637-649, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30666160

RESUMO

Purpose: Increasing studies have shown that microRNA-4458 (miR-4458) is associated with human cancer progression. However, the molecular mechanism of miR-4458 in non-small-cell lung cancer (NSCLC) remains largely unknown. This study aims to reveal the biological function of miR-4458 in NSCLC. Materials and methods: The expression of miR-4458 in NSCLC cells was evaluated by qRT-PCR. Cell proliferation and migration assay were carried out in vitro after transfection. A luciferase reporter and Western blot assay were performed to identify the functional target of miR-4458. Results: The study indicated that miR-4458 was markedly downregulated in NSCLC cells. Overexpression of miR-4458 strongly reduced the proliferation and migration in NSCLC cell lines. In addition, miR-4458 inhibited the progression of migration and epithelial-mesenchymal transition (EMT) through the PI3K/AKT pathway. Luciferase report assay demonstrated that HMGA1 was a target gene for miR-4458. Conclusion: The results indicate that miR-4458 participated in the process of migration and EMT via directly targeting HMGA1 and miR-4458 might be a potential novel therapeutic target in NSCLC.

14.
Sci Rep ; 7(1): 9370, 2017 08 24.
Artigo em Inglês | MEDLINE | ID: mdl-28839156

RESUMO

Lung cancer, the most commonly diagnosed cancer worldwide, usually presents as solid pulmonary nodules (SPNs) on early diagnostic images. Classification of malignant disease at this early timepoint is critical for improving the success of surgical resection and increasing 5-year survival rates. 18F-fluorodeoxyglucose (18F-FDG) PET/CT has demonstrated value for SPNs diagnosis with high sensitivity to detect malignant SPNs, but lower specificity in diagnosing malignant SPNs in populations with endemic infectious lung disease. This study aimed to determine whether quantitative heterogeneity derived from various texture features on dual time FDG PET/CT images (DTPI) can differentiate between malignant and benign SPNs in patients from granuloma-endemic regions. Machine learning methods were employed to find optimal discrimination between malignant and benign nodules. Machine learning models trained by texture features on DTPI images achieved significant improvements over standard clinical metrics and visual interpretation for discriminating benign from malignant SPNs, especially by texture features on delayed FDG PET/CT images.


Assuntos
Fluordesoxiglucose F18 , Granuloma/diagnóstico por imagem , Granuloma/patologia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Nódulo Pulmonar Solitário/diagnóstico por imagem , Nódulo Pulmonar Solitário/patologia , Área Sob a Curva , Diagnóstico Diferencial , Feminino , Humanos , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/patologia , Aprendizado de Máquina , Masculino , Curva ROC , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
15.
Langmuir ; 33(5): 1248-1255, 2017 02 07.
Artigo em Inglês | MEDLINE | ID: mdl-28088856

RESUMO

The interest in the design and controllable fabrication of hollow carbon spheres (HCSs) emanates from their tremendous potential applications in adsorption, energy conversion and storage, and catalysis. However, the effective synthesis of uniform HCSs with high surface area and abundant micropores remains a challenge. In this work, HCSs with tunable microporous shells were rationally synthesized via the hard-template method using resorcinol (R) and formaldehyde (F) as a carbon precursor. HCSs with a very high surface area (1369 m2/g) and abundant micropores (0.53 cm3/g) can be obtained with the assistance of additional inorganic silanes (TEOS) simultaneously with the carbon source (RF). Interestingly, the extra-abundant micropores showed favorable adsorption for CO2, resulting in a 1.5 times increase in the CO2 adsorption capacity compared to that of normal HCSs under the same conditions. Meanwhile, these HCSs hold potential for use in the separation of gases such as CO2 and N2.

16.
Eur J Radiol ; 85(10): 1744-1749, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27666611

RESUMO

PURPOSE: This study is aimed to compare the diagnostic power of using quantitative analysis or visual analysis with single time point imaging (STPI) PET/CT and dual time point imaging (DTPI) PET/CT for the classification of solitary pulmonary nodules (SPN) lesions in granuloma-endemic regions. METHODS: SPN patients who received early and delayed (18)F-FDG PET/CT at 60min and 180min post-injection were retrospectively reviewed. Diagnoses are confirmed by pathological results or follow-ups. Three quantitative metrics, early SUVmax, delayed SUVmax and retention index(the percentage changes between the early SUVmax and delayed SUVmax), were measured for each lesion. Three 5-point scale score was given by blinded interpretations performed by physicians based on STPI PET/CT images, DTPI PET/CT images and CT images, respectively. ROC analysis was performed on three quantitative metrics and three visual interpretation scores. RESULT: One-hundred-forty-nine patients were retrospectively included. The areas under curve (AUC) of the ROC curves of early SUVmax, delayed SUVmax, RI, STPI PET/CT score, DTPI PET/CT score and CT score are 0.73, 0.74, 0.61, 0.77 0.75 and 0.76, respectively. There were no significant differences between the AUCs in visual interpretation of STPI PET/CT images and DTPI PET/CT images, nor in early SUVmax and delayed SUVmax. The differences of sensitivity, specificity and accuracy between STPI PET/CT and DTPI PET/CT were not significantly different in either quantitative analysis or visual interpretation. CONCLUSION: In granuloma-endemic regions, DTPI PET/CT did not offer significant improvement over STPI PET/CT in differentiating malignant SPNs in both quantitative analysis and visual interpretation.


Assuntos
Fluordesoxiglucose F18 , Granuloma/diagnóstico por imagem , Neoplasias Pulmonares/diagnóstico por imagem , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos , Interpretação de Imagem Radiográfica Assistida por Computador/métodos , Nódulo Pulmonar Solitário/diagnóstico por imagem , Adulto , Meios de Contraste , Diagnóstico Diferencial , Feminino , Granuloma/patologia , Humanos , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/normas , Curva ROC , Interpretação de Imagem Radiográfica Assistida por Computador/normas , Compostos Radiofarmacêuticos , Estudos Retrospectivos , Sensibilidade e Especificidade , Nódulo Pulmonar Solitário/patologia
17.
Biomed Res Int ; 2016: 4763824, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27034938

RESUMO

In this clinical study, we have compared routine diagnostic dose (131)I scan and (99m)TcO4(-) thyroid scintigraphy with therapeutic dose (131)I imaging for accurate thyroid remnant estimation after total thyroidectomy. We conducted a retrospective review of the patients undergoing total thyroidectomy for differentiated thyroid carcinoma (DTC) and subsequently receiving radioactive iodine (RAI) treatment to ablate remnant thyroid tissue. All patients had therapeutic dose RAI whole body scan, which was compared with that of diagnostic dose RAI, (99m)TcO4(-) thyroid scan, and ultrasound examination. We concluded that therapeutic dose RAI scan reveals some extent thyroid remnant in all DTC patients following total thyroidectomy. Diagnostic RAI scan is much superior to ultrasound and (99m)TcO4(-) thyroid scan for the postoperative estimation of thyroid remnant. Ultrasound and (99m)TcO4(-) thyroid scan provide little information for thyroid remnant estimation and, therefore, would not replace diagnostic RAI scan.


Assuntos
Radioisótopos do Iodo/uso terapêutico , Glândula Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/radioterapia , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Cintilografia , Tecnécio/uso terapêutico , Glândula Tireoide/patologia , Glândula Tireoide/efeitos da radiação , Glândula Tireoide/cirurgia , Neoplasias da Glândula Tireoide/patologia , Neoplasias da Glândula Tireoide/cirurgia , Tireoidectomia , Imagem Corporal Total
18.
Biomed Res Int ; 2016: 8549635, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26949707

RESUMO

PURPOSE: The aim of this study is to synthesize and evaluate (68)Ga-labeled Lissamine Rhodamine B (LRB) as a new radiotracer for imaging MDA-MB-231 and MCF-7 cells induced tumor mice by positron emission tomography (PET). METHODS: Firstly, we performed the radio synthesis and microPET imaging of (68)Ga(DOTA-LRB) in athymic nude mice bearing MDA-MB-231 and MCF-7 human breast cancer xenografts. Additionally, the evaluations of (18)F-fluorodeoxyglucose (FDG), as a glucose metabolism radiotracer for imaging tumors in the same xenografts, have been conducted as a comparison. RESULTS: The radiochemical purity of (68)Ga(DOTA-LRB) was >95%. MicroPET dynamic imaging revealed that the uptake of (68)Ga(DOTA-LRB) was mainly in normal organs, such as kidney, heart, liver, and brain and mainly excreted from kidney. The MDA-MB-231 and MCF-7 tumors were not clearly visible in PET images at 5, 15, 30, 40, 50, and 60 min after injection of (68)Ga(DOTA-LRB). The tumor uptake values of (18)F-FDG were 3.79 ± 0.57 and 1.93 ± 0.48%ID/g in MDA-MB-231 and MCF-7 tumor xenografts, respectively. CONCLUSIONS: (68)Ga(DOTA-LRB) can be easily synthesized with high radiochemical purity and stability; however, it may be not an ideal PET radiotracer for imaging of MDR-positive tumors.


Assuntos
Neoplasias da Mama/diagnóstico por imagem , Meios de Contraste/farmacologia , Tomografia por Emissão de Pósitrons/métodos , Rodaminas/farmacologia , Animais , Neoplasias da Mama/metabolismo , Neoplasias da Mama/patologia , Meios de Contraste/síntese química , Fluordesoxiglucose F18/farmacologia , Humanos , Células MCF-7 , Camundongos , Compostos Radiofarmacêuticos/farmacologia , Rodaminas/síntese química , Distribuição Tecidual , Ensaios Antitumorais Modelo de Xenoenxerto
19.
Medicine (Baltimore) ; 94(31): e1308, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26252311

RESUMO

This article investigates the association of the time interval between the diagnostic dose and ablation with the stunning effect, when a 74 MBq I pretherapy scanning was performed on patients with differentiated thyroid carcinoma (DTC); the patients who were diagnosed as DTC and would be performed radioiodine (RAI) ablation of thyroid remnants or metastases were recruited during January 2011 and May 2012 in our hospital.Thirty-seven patients with DTC who had the RAI ablation of thyroid remnants or metastases for the first time were recruited. All the patients received a dose of 1850 to 7400 MBq of I for ablation and a diagnostic scan was performed 24 hours after the administration of 74 MBq I before ablation. A posttherapy scan was performed 2 to 7 days after the ablation. The patients were broken down into 3 groups (G1, G2, and G3) according to the interval time between the diagnostic dose and therapy (1-3, 4-7, and >7 days). The fractional concentrations of I in remnants or functional metastases were quantified and expressed as therapeutic/diagnostic (Rx/Dx). The level of significance was set at 0.05.Sixty-seven foci were found both on pretherapy and posttherapy scans, the mean ratio of Rx/Dx was 0.43 ±â€Š0.29, and the ratio of 49 foci (73.13%) was <0.6. The ratios in G1, G2, and G3 were 0.46 ±â€Š0.29, 0.29 ±â€Š0.18, and 0.55 ±â€Š0.33, respectively. The differences between G1 and G2, and G2 and G3 were statistically significant (t = 2.40, P = 0.021 and t = 3.28, P = 0.002), whereas the difference between G1 and G3 was not significant (t = 1.01, P = 0.319).By a diagnostic scan of 74 MBq I, stunning prominently occurs with a time of 4 to 7 days between the diagnostic dose and ablation. We recommend that for less stunning effect, RAI ablation should be performed within 3 days or postponed until 1 week after the diagnostic dose administrated.


Assuntos
Técnicas de Ablação , Carcinoma/diagnóstico por imagem , Carcinoma/cirurgia , Radioisótopos do Iodo , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/cirurgia , Adolescente , Adulto , Idoso , Feminino , Humanos , Radioisótopos do Iodo/uso terapêutico , Masculino , Pessoa de Meia-Idade , Cintilografia , Compostos Radiofarmacêuticos/uso terapêutico , Estudos Retrospectivos , Tireoidectomia , Fatores de Tempo , Adulto Jovem
20.
Clin Nucl Med ; 39(9): 835-6, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24662659

RESUMO

A 62-year-old man with a history of breakpoint cluster region-ABL-positive chronic myeloid leukemia treated with hydroxyurea and interferon alfa for 4 years presented a lesion in the left lateral lobe of the liver. Besides an FDG-avid lesion, his 18F-FDG PET/CT study showed intense and diffuse FDG uptake (reminiscent of a hepatic superscan) throughout the rest of the left lobe and the right anterior lobe of the liver. This interesting superscan indicated that patients with chronic myeloid leukemia may show hepatic involvement by leukemia cells.


Assuntos
Leucemia Mielogênica Crônica BCR-ABL Positiva/diagnóstico por imagem , Fígado/diagnóstico por imagem , Fluordesoxiglucose F18 , Humanos , Masculino , Pessoa de Meia-Idade , Tomografia por Emissão de Pósitrons , Compostos Radiofarmacêuticos
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