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1.
Int J Infect Dis ; 2020 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-33017697

RESUMO

OBJECTIVE: This study aims to present clinical characteristics of 30 hospitalized cases with epileptic seizure and coronavirus disease 2019(COVID-19).  METHODS: This is a retrospective observational research. Clinical data were extracted from electronic medical records in 1550 patients with laboratory-confirmed diagnosis of COVID-19 who hospitalized in Wuhan Central Hospital, China, from 1 January to 31 April, 2020. 30 COVID-19 patients with the diagnosis of epilepsy were enrolled. The clinical characteristics, complications, treatments,and clinical outcomes of 30 cases were collected. RESULT: Of 30 patients with diagnosis of epilepsy and COVID-19, 13 patients(43.4%) had new-onset epileptic seizure without epilepsy history(new-onset seizure group,NS group), 10 patients(33.3%) with epilepsy history had recurrent epileptic seizure(recurrent seizure group,RS group) and 7 patients(23.3%) with epilepsy history had no seizure during the course of COVID-19 (epilepsy history group,EH group). Patients in RS group had more other neurological disease history except for epilepsy than those in NS group and EH group(7/10[70%] VS 1/13 [7.7%]VS1/7[14.3%]), and the difference between RS group and NS group is significant (P < 0.05). Patients in NE group and RS group suffered more severe/critical COVID-19 infection than patients in EH group (10/13[76.9%] VS 6/10[60%] VS 1/7[14.3%]),and the difference between NS group and EH group is significant (P < 0.05). 36.7% of patients had 1 to 5 complications,and 46.4% of patients had 6-10 complications.The complications in patients with seizure(in RS group and NS group) seem to be more than those without seizure(in EH group), but it doesn't have statistic difference. The proportion of antiepileptic drugs (AEDs) treatment before admission was higher in EH group than in RE group(7/7 [100%] VS 2/10 [20%], P < 0.05). The mortality of 30 patients with epilepsy and COVID-19 was 36.67%. The mortality of NS group(38.5%) and RS group(50%) were a little higher than in EH group(14.3%). None of convalescent patients had recurrent seizure, and there was no more death in the 3 month follow-up after discharge. CONCLUSIONS: COVID-19 Patients with recurrent epileptic seizure had more underlying neurological diseases than patients who had epilepsy history but without seizure.Patients with new-onset and recurrent epileptic seizure suffered more sever/critical COVID-19, which may lead to a worse prognosis.If patients with epilepsy history continue using AEDs during COVID-19 pandemics, the risk of recurrent seizure may reduce, and a good prognosis for patients with epilepsy history could be expected.

2.
Cell Cycle ; : 1-19, 2020 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-33017562

RESUMO

Fibrotic microenvironment has been reported to have a pro-metastasis effect on tumor cells, but the mechanism remains unclear. The current study aimed to explore the underlying mechanism by which the fibrotic microenvironment affects tumor cells. A tumor metastasis model was established by injecting tumor cells containing GFP into mice with pulmonary fibrosis. Lung tissues and fibroblasts were harvested, and conditioned medium (CM) were collected from fibrotic lungs and fibroblasts. Hematoxylin & eosin staining and immunohistochemistry were used to detect pulmonary metastasis and FSP1 expression, respectively. Bioinformatics and dual-luciferase reporter assay proved that the target genes of ZEB1-AS1 and miR-200b-3p were miR-200b-3p and ZEB1, respectively. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect the expressions of GFP, ZEB1-AS1, and miR-200b-3p. Transwell assay, Annexin V/PI assay, and colorimetry were performed to examine the effects of CM, ZEB1-AS1, miR-200b-3p, and ZEB1 on cell invasion, apoptosis, and the activity level of caspase-3/-9. Pulmonary metastasis was promoted and the expressions of FSP1 and GFP were increased in mice with pulmonary fibrosis. CM enhanced the invasion and inhibited the apoptosis of tumor cells. SiZEB1-AS1 and siZEB1 inhibited the invasion and apoptosis of tumor cells, while miR-200b-3p inhibitor had the opposite effect of SiZEB1-AS1 and siZEB1, and further reversed the effect of siZEB1 on tumor cell invasion and apoptosis. SiZEB1-AS1 reversed the effects of both miR-200b-3p inhibitor and miR-200b-3p inhibitor+siZEB1 on tumor cell invasion and apoptosis. Fibrotic microenvironment promoted the metastatic seeding of tumor cells into the lungs via mediating the ZEB1-AS1/miR-200b-3p/ZEB1 signaling.

3.
Nanotechnology ; 31(50): 505712, 2020 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-33021232

RESUMO

Nanodiamonds are popular biological labels because of their superior mechanical and optical properties. Their surfaces bridging the core and surrounding medium play a key role in determining their bio-linkage and photophysical properties. n-diamond is a mysterious carbon allotrope whose crystal structure remains debated. We study the influence of the crystallization temperature on the fluorescence properties of the colloidal n-diamond quantum dots (n-DQDs) with sizes of several nanometers. They exhibit multiband fluorescence across the whole visible region which depends sensitively on the crystallization temperature. Their surfaces turn from hydrophobic ones rich of sp2-bonded carbon into hydrophilic ones rich of carboxyl derivatives and hydroxyl groups as the crystallization temperature increases. The different surface states correlated with the surface structures account for the distinct fluorescence properties of the n-DQDs crystallized at different temperatures. These high-purity ultrasmall n-DQDs with tunable surface chemistry and fluorescence properties are promising multicolor biomarkers and lighting sources.

4.
Clin Cardiol ; 2020 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-33026120

RESUMO

BACKGROUD: The association between underlying comorbidities and cardiac injury and the prognosis in coronavirus disease 2019 (COVID-19) patients was assessed in this study. HYPOTHESIS: The underlying comorbidities and cardiac injury may be associated with the prognosis in COVID-19 patients. METHODS: A systematic search was conducted in PubMed, EMBASE, Web of science, and The Cochrane library from December 2019 to July 2020. The odds ratio (OR) and 95% confidence intervals (95% CI) were used to estimate the probability of comorbidities and cardiac injury in COVID-19 patients with or without severe type, or in survivors vs nonsurvivors of COVID-19 patients. RESULTS: A total of 124 studies were included in this analysis. A higher risk for severity was observed in COVID-19 patients with comorbidities. The pooled result in patients with hypertension (OR 2.57, 95% CI: 2.12-3.11), diabetes (OR 2.54, 95% CI: 1.89-3.41), cardiovascular diseases (OR 3.86, 95% CI: 2.70-5.52), chronic obstractive pulmonary disease (OR 2.71, 95% CI: 1.98-3.70), chronic kidney disease (OR 2.20, 95% CI: 1.27-3.80), and cancer (OR 2.42, 95% CI: 1.81-3.22) respectively. All the comorbidities presented a higher risk of mortality. Moreover, the prevalence of acute cardiac injury is higher in severe group than in nonsevere group, and acute cardiac injury is associated with an increased risk for in-hospital mortality. CONCLUSION: Comorbidities and acute cardiac injury are closely associated with poor prognosis in COVID-19 patients. It is necessary to continuously monitor related clinical indicators of organs injury and concern comorbidities in COVID-19 patients.

5.
New Phytol ; 2020 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-33006771

RESUMO

Post-translational modification of proteins mediated by SIZ1, a small ubiquitin-like modifier (SUMO) E3 ligase, regulates multiple biological processes in plants. However, its role in the regulation of lateral root formation remains unclear. Here, we demonstrate that the apple SUMO E3 ligase MdSIZ1 promotes lateral root formation. Using a yeast two-hybrid system, the auxin response factor MdARF8 was screened out as a protein-protein interaction partner of the SUMO-conjugating E2 enzyme MdSCE1, indicating that MdARF8 may be a substrate for MdSIZ1. The interaction between MdARF8 and MdSCE1 was confirmed by pull-down, Y2H, and Co-IP assays. MdSIZ1 enhanced the conjugating enzyme activity of MdSCE1 to form a MdSCE1-MdSIZ1-MdARF8 complex, thereby facilitating SUMO modification. We identified two arginine substitution mutations at K342 and K380 in MdARF8 that blocked MdSIZ1-mediated SUMOylation, indicating that K342 and K380 are the principal SUMOylation sites of the MdARF8 protein. Moreover, MdARF8 promoted lateral root formation in transgenic apple plants, and the phenotype of reduced lateral roots in the Arabidopsis siz1-2 mutant was restored in siz1-2/MdARF8 complementary plants. Our findings reveal an important role for sumoylation in the regulation of lateral root formation in plants.

6.
ACS Nano ; 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33001627

RESUMO

The brightness of organic fluorescence materials determines their resolution and sensitivity in fluorescence display and detection. However, strategies to effectively enhance the brightness are still scarce. Conventional planar π-conjugated molecules display excellent photophysical properties as isolated species but suffer from aggregation-caused quenching effect when aggregated owing to the cofacial π-π interactions. In contrast, twisted molecules show high photoluminescence quantum yield (ΦPL) in aggregate while at the cost of absorption due to the breakage in conjugation. Therefore, it is challenging to integrate the strong absorption and high solid-state ΦPL, which are two main indicators of brightness, into one molecule. Herein, we propose a molecular design strategy to boost the brightness through the incorporation of planar blocks into twisted skeletons. As a proof-of-concept, twisted small-molecule TT3-oCB with larger π-conjugated dithieno[3,2-b:2',3'-d]thiophene unit displays superb brightness at the NIR-IIb (1500-1700 nm) than that of TT1-oCB and TT2-oCB with smaller thiophene and thienothiophene unit, respectively. Whole-body angiography using TT3-oCB nanoparticles presents an apparent vessel width of 0.29 mm. Improved NIR-IIb image resolution is achieved for femoral vessels with an apparent width of only 0.04 mm. High-magnification through-skull microscopic NIR-IIb imaging of cerebral vasculature gives an apparent width of ∼3.3 µm. Moreover, the deeply located internal organ such as bladder is identified with high clarity. The present molecular design philosophy embodies a platform for further development of in vivo bioimaging.

7.
Mar Drugs ; 18(10)2020 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-33003577

RESUMO

Inflammatory bowel disease (IBD) has been gradually considered a public health challenge worldwide. Sulfated polysaccharides, extracted from seaweed, have been shown to have an anti-inflammatory effect on the disease[...].

8.
Stat Methods Med Res ; : 962280220962516, 2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-33059531

RESUMO

Cancer incidence and mortality are typically presented as age-standardized rates. Inference about these rates becomes complicated when denominators involve sampling errors. We propose a bias-corrected rate estimator as well as its corresponding variance estimator that take into account sampling errors in the denominators. Confidence intervals are derived based on the proposed estimators as well. Performance of the proposed methods is evaluated empirically based on simulation studies. More importantly, advantage of the proposed method is demonstrated and verified in a real-life study of cancer mortality disparity. A web-based, user-friendly computational tool is also being developed at the National Cancer Institute to accompany the new methods with the first application being calculating cancer mortality rates by US-born and foreign-born status. Finally, promise of proposed estimators to account for errors introduced by differential privacy procedures to the 2020 decennial census products is discussed.

9.
Exp Gerontol ; 141: 111110, 2020 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-33045358

RESUMO

BACKGROUND: Dehydroepiandrosterone (DHEA) has been aggressively sold as a dietary supplement to boost testosterone levels although the impact of DHEA supplementation on testosterone levels has not been fully established. Therefore, we performed a systematic review and meta-analysis of RCTs to investigate the effect of oral DHEA supplementation on testosterone levels. METHODS: A systematic literature search was performed in Scopus, Embase, Web of Science, and PubMed databases up to February 2020 for RCTs that investigated the effect of DHEA supplementation on testosterone levels. The estimated effect of the data was calculated using the weighted mean difference (WMD). Subgroup analysis was performed to identify the source of heterogeneity among studies. RESULTS: Overall results from 42 publications (comprising 55 arms) demonstrated that testosterone level was significantly increased after DHEA administration (WMD: 28.02 ng/dl, 95% CI: 21.44-34.60, p = 0.00). Subgroup analyses revealed that DHEA increased testosterone level in all subgroups, but the magnitude of increment was higher in females compared to men (WMD: 30.98 ng/dl vs. 21.36 ng/dl); DHEA dosage of ˃50 mg/d compared to ≤50 mg/d (WMD: 57.96 ng/dl vs. 19.43 ng/dl); intervention duration of ≤12 weeks compared to ˃12 weeks (WMD: 44.64 ng/dl vs. 19 ng/dl); healthy participants compared to postmenopausal women, pregnant women, non-healthy participants and androgen-deficient patients (WMD: 52.17 ng/dl vs. 25.04 ng/dl, 16.44 ng/dl and 16.47 ng/dl); and participants below 60 years old compared to above 60 years old (WMD: 31.42 ng/dl vs. 23.93 ng/dl). CONCLUSION: DHEA supplementation is effective for increasing testosterone levels, although the magnitude varies among different subgroups. More study needed on pregnant women and miscarriage.

10.
Prostaglandins Leukot Essent Fatty Acids ; 162: 102184, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33045533

RESUMO

Maternal factors such as the diet can impact human milk fatty acid profiles. We hypothesized that mature human milk fatty acid profiles differ among regions of China. To test our hypothesis, we conducted a systematic review to calculate regional average contents of fatty acids and the statistical significance of regional differences in fatty acids. We searched both Chinese and English literature databases and selected 21 articles, including 11 in Chinese and 10 in English. We categorized regions of China by 3 ways: 1) north vs. south; 2) inland vs. coastal; 3) socioeconomic development levels. The ratios of ΣSFAs:ΣMUFAs:ΣPUFAs were similar between regions and the average was 1:1:0.7. Contents of palmitic, oleic, and linoleic acids were also similar between regions and together they accounted for more than 70% of all fatty acids in mature human milk. Conversely, concentrations of ALA and DHA differed more than palmitic, oleic, and linoleic acids. We also found that it might be necessary to reduce maternal dietary contents of potentially harmful fatty acids such as erucic acid to minimize detrimental effects on infant health. To our knowledge, this study represents the first systematic review that quantitatively investigated the regional similarities and differences in mature human milk fatty acid contents and is therefore significant for academia and policy makers.

11.
Artigo em Inglês | MEDLINE | ID: mdl-33048523

RESUMO

Device-scale, uniform, and controllable deposition of nanoparticles on various substrates is fundamentally important not only for the fabrication of thin-film devices but also for the large sample statistics of single-particle performances. However, it is challenging to obtain such predefined depositions using a simple and efficient method. Here, we present a novel strategy for obtaining the uniform and particle density/spacing-tunable deposition of nanorods on a linker-free substrate. The deposition is driven by the tailored particle-substrate depletion attraction owing to the size-matched design of the substrate roughness and the nanorod diameter. Both gold nanorods and upconversion nanorods were applied to demonstrate the generality of the method. The high particle density of more than 21 per µm2 and correspondingly the small particle spacing of fewer than 0.3 µm were achieved on a scalable substrate template. On this basis, orientational ordering and pattern-selective deposition of nanorods were realized by controlling the liquid flow rate and employing the substrate with patterned roughness areas, respectively. With the roughness-directed density-tunable depositions of nanorods integrated onto a single platform, multiplexed gold nanorod assembly and programmable surface-enhanced Raman mapping were achieved, with a promising prospect in information encoding by using the Raman signals as the translation units. The thermal stability and related transition temperature of about 160 °C of gold nanorods were also revealed as an application of single-particle statistics. This practical method could be extended to wide ranges of potential applications in plasmonic coupling devices, cryptography, or single-particle performance statistics with the feature of the high-throughput, low-cost, and scalable fabrication.

12.
Artigo em Inglês | MEDLINE | ID: mdl-33069857

RESUMO

During development, highly dynamic reconstruction of microtubules is involved in many cellular processes, including cell division, migration, morphological changes, and material transportation within cells. Microtubule severing proteins (MSPs), with the function of cutting microtubules into short parts, are important regulators in the reconstruction of microtubule arrays. Fidgetin (fign) and its family members fidgetin like 1 (fignl1) and fignl2 are MSPs, and knowledge on the expression patterns of fign family members will benefit our understanding of their primary roles in one specific stage during development. In this study, we compared the evolutionary relationships of fign family members and found that fignl2 is closer to fign than fignl1. We utilized the zebrafish model and in situ hybridization (ISH) to parallelly identify the expression features of fign family members. Our findings revealed that before 12 h post fertilization (hpf), the expression patterns of fign and fignl1 and fignl2 genes were similar, but differences arose thereafter. Fignl2 transcripts were present in more tissues and organs of zebrafish after 12 hpf and potentially exhibited more ubiquitous functions. This study is the first to assess systematic comparable data on the expression patterns of fign family members during development.

13.
ACS Nano ; 2020 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-33073577

RESUMO

Efforts to impart responsiveness to environmental stimuli in artificial hydrogel fibers are crucial to intelligent, shape-memory electronics and weavable soft robots. However, owing to the vulnerable mechanical property, poor processability, and the dearth of scalable assembly protocols, such functional hydrogel fibers are still far from practical usage. Herein, we demonstrate an approach toward the continuous fabrication of an electro-responsive hydrogel fiber by using the self-lubricated spinning (SLS) strategy. The polyelectrolyte inside the hydrogel fiber endows it with a fast electro-response property. After solvent exchange with triethylene glycol (TEG), the maximum tensile strength of the hydrogel fiber increases from 114 kPa to 5.6 MPa, far superior to those hydrogel fiber-based actuators reported previously. Consequently, the flexible and mechanical stable hydrogel fiber is knitted into various complex geometries on demand such as a crochet flower, triple knot, thread tube, pentagram, and hollow cage. Additionally, the electrochemical-responsive ionic hydrogel fiber is capable of acting as soft robots underwater to mimic biological motions, such as Mobula-like flapping, jellyfish-mimicking grabbing, sea worm-mimicking multi-degree of freedom movements, and human finger-like smart gesturing. This work not only demonstrates an example for the large-scale production of previous infeasible hydrogel fibers, but also provides a solution for the rational design and fabrication of hydrogel woven intelligent devices.

14.
Phytother Res ; 2020 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-32893384

RESUMO

Exposure to PM2.5 (particulate matter with an aerodynamic diameter ≤ 2.5 µm) has been associated with increased cardiopulmonary outcomes, mediated by a hypothesized biological mechanism of systemic inflammation and oxidation. This randomized, double-blinded and placebo-controlled trial among 120 healthy adults in Wuhan, China, was conducted to evaluate whether the supplementation of herbal product composed of Ginseng, Lilii Bulbus and Poria (GLP) which have been shown to have anti-inflammatory and anti-oxidant activity offers protective effects on PM2.5 -induced damage to cardiopulmonary health. Participants received four rounds of health examinations and two rounds of blood sample collection from November 2018 to January 2019. Compared to the placebo group, the GLP group showed significant increased antioxidant biomarkers such as superoxide dismutase (SOD) and paraoxonase1 (PON1). What is more, interleukin-6 (IL-6), an inflammatory biomarker, was significantly decreased in the GLP group. In addition, nitric oxide and club cell secretory protein (CC16) were increased but heart rate was decreased in the GLP group. As for pulmonary function indicators, significantly increased fractional exhaled nitric oxide (FeNO) was observed in the GLP group. Taken together, we concluded that GLP supplementation is associated with decreased inflammatory biomarker and increased antioxidant biomarkers suggesting cardiopulmonary benefits against PM2.5 exposure among young adults in China.

15.
Zhongguo Gu Shang ; 33(8): 721-4, 2020 Aug 25.
Artigo em Chinês | MEDLINE | ID: mdl-32875761

RESUMO

OBJECTIVE: To analyze and compare the hidden blood loss of minimally invasive percutaneous plate osteosynthesis(MIPPO) combined with locking plate fixation and intramedullary nail fixation in the treatment of tibial shaft fracture. METHODS: One hundred and ninety-one cases of tibial shaft fracture treated from January 2017 to January 2019 were analyzed retrospectively. The patients were all treated with closed reduction and divided into two groups:group A (110 cases) and group B (81 cases). In group A, 78 males and 32 females were treated with MIPPO combined with locking plate. The age ranged from 19 to 74 (45.32±11.79) years old. According to AO classification, 42cases were type 42-A, 45 were type 42-B and 23 were type 42-C fractures. Group B was treated with intramedullary nail, including 65 males and 16 females, aged 19 to 84 (45.44± 14.32) years old. According to AO classification, there were 39 cases of type 42-A, 29 cases of type 42-B and 13 cases of type 42-C. The operation time, intraoperative blood loss and hidden blood loss were observed and compared between the two groups. RESULTS: On the first day, the hidden blood loss was (155.27±47.89) ml in group A and (160.43±131.42) ml in group B, the difference was statistically significant (P<0.001);on the third day, the hidden blood loss was (102.70±94.79) ml in group A and (338.23±85.24) ml in group B, the difference was statistically significant (P<0.001). There was no significant difference between the two groups in gender, age, height, weight, fracture type and preoperative Hct (P>0.05). CONCLUSION: In the treatment of tibial shaft fracture with intramedullary nail, there is obvious hidden blood loss, which is much higher than expected.


Assuntos
Fixação Intramedular de Fraturas , Fraturas da Tíbia , Adulto , Idoso , Idoso de 80 Anos ou mais , Pinos Ortopédicos , Placas Ósseas , Feminino , Fixação Interna de Fraturas , Consolidação da Fratura , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
16.
Aging (Albany NY) ; 122020 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-32897245

RESUMO

The mortality rate of ovarian cancer is the highest among gynaecological cancers, primarily due to metastatic symptoms. Recent studies have shown that HOX genes are crucial in tumour progression, but the underlying mechanisms remain unclear. Here, HOXC10 expression was examined in ovarian cancer tissues. The function of HOXC10 in ovarian cancer metastasis was investigated in vitroand via intraperitoneal injection in vivo. A total of 158 ovarian cancer patients with adequate records were enrolled for analysis. HOXC10 was associated with metastasis and poor prognosis in ovarian cancer. In vitro, HOXC10 overexpression promoted ovarian cancer cell migration. Moreover, HOXC10 positively regulated Slug expression, altering the migration ability of cancer cells. Furthermore, our study showed that miR-222-3p was a suppressor of HOXC10. In vivo, a decrease in hepatic metastasis was seen in xenograft mice harbouring tumours with stable HOXC10 overexpression after miR-222-3p agomir (an overexpression reagent) injection. This study provides the first evidence that HOXC10 promotes ovarian cancer metastasis by regulating the transcription of the EMT-related gene Slug. Moreover, we found that HOXC10 is regulated by miR-222-3p. These data highlight the crucial role of HOXC10 in enhancing ovarian cancer metastasis and may provide a therapeutic target for ovarian cancer.

17.
Sci Total Environ ; 754: 142167, 2020 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-32916497

RESUMO

BACKGROUND: Previous studies on environmental pollutant exposure during pregnancy have mostly focused on individual chemical substances or single urine measurements. Thus, our understanding of the potential cumulative or interactive effects of exposure is limited. OBJECTIVE: We aimed to ascertain the characteristics and predictors of exposure to environmental chemicals over three trimesters among pregnant women. METHODS: We measured the concentrations of 34 chemicals in spot urine samples provided by 745 participants in their early, middle, and late pregnancy. We calculated Spearman correlation coefficients (SCC) between exposure levels of multiple chemicals in each trimester. K-means clustering and principal components analysis (PCA) were applied to classify the populations and reduce data dimensionality. We used generalized linear models (GLM) to confirm predictors of each cluster and principal component. RESULTS: SCC showed that the correlations of chemical concentrations from the same classes were higher than those among concentrations of different classes. Cluster analysis categorized participants into three clusters, and each cluster represented different chemical concentrations. We restricted the principal components to six, which explained more than 50% of the data variations. Several physiological, socio-demographic factors, and behavior patterns were related to different clusters and principal components. CONCLUSION: Distinct exposure patterns and dominant exposure components of multiple environmental chemicals among pregnant women might help research the potential health effects of exposure to chemical mixtures and develop relevant public health interventions.

18.
Br J Cancer ; 2020 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-32901134

RESUMO

BACKGROUND: It is unclear whether bisphosphonates are associated with risk of cancers. Therefore, this meta-analysis aimed to evaluate the effect of bisphosphonates on overall cancers. METHODS: A search in Pubmed, Embase, Cochrane Library and Web of Science databases was conducted, from the inception date of each resource to September 26, 2019. The summarised effect estimates with 95% CIs were calculated using a random-effect model. Heterogeneity and publication bias were explored. RESULTS: Thirty-four articles were included in this study (4,508,261 participants; 403,196 cases). The results revealed that bisphosphonates significantly decreased the risk of colorectal cancer (RR = 0.89, 95% CI: 0.81-0.98), breast cancer (RR = 0.87, 95% CI: 0.82-0.93) and endometrial cancer (RR = 0.75, 95% CI: 0.61-0.94), but no significant association was observed in all-cause cancer. Furthermore, nitrogen-containing bisphosphonates only had protective effects both on breast cancer (RR = 0.94, 95% CI: 0.90-0.99) and endometrial cancer (RR = 0.70, 95% CI: 0.54-0.92). Non-nitrogen-containing bisphosphonates tended to increase the risk of liver cancer (RR = 2.14, 95% CI: 1.23-3.72) and pancreas cancer (RR = 1.75, 95% CI: 1.32-2.33). CONCLUSION: Bisphosphonates are significantly associated with risk reduction of colorectal, breast and endometrial cancer, especially nitrogen-containing bisphosphonates. It should be noted that non-nitrogen-containing bisphosphonates might increase the risk of liver and pancreas cancer. Large prospective cohort studies are needed to find the causal association between bisphosphonates and risk of cancers.

19.
Appl Opt ; 59(24): 7477-7483, 2020 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-32902517

RESUMO

A reconfigurable photonic binary phase-coded microwave signal generator with fundamental/subharmonic carrier frequency is proposed and experimentally investigated based on a dual-electrode dual parallel Mach-Zehnder modulator (DE-DPMZM). The local oscillator (LO) signal and coding signal are intensity modulated and phase modulated, respectively, on the two arms of the DE-DPMZM. The bias voltage of the intensity modulator is set to the quadrature or maximum working points to produce fundamental or subharmonic frequency, respectively. By precisely adjusting the amplitude of the LO signal and the bias voltage of the parent modulator, the light carriers of both arms of the DE-DPMZM can be eliminated. After detection, binary phase-coded microwave signal with frequency equal to or twice the frequency of the LO signal can be generated. The proposed system has a simple structure, high reconfigurability, and good frequency tunability due to its avoidance of using optical filters. In the experiment, phase-coded microwave waveforms at 6 GHz and 11 GHz are generated by using 6 GHz and 11 GHz LO signals or 3 GHz and 5.5 GHz LO signals, respectively. Meanwhile, the performance is evaluated in terms of phase recovery accuracy and pulse compression capability. The experimental results show that the proposed generator has high peak-to-sidelobe ratio, which has practical significance for radar detection of weak targets.

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