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1.
Ecol Evol ; 9(19): 11344-11352, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31641477

RESUMO

In the tropics of South China, climate change induced more rainfall events in the wet season in the last decades. Moreover, there will be more frequently spring drought in the future. However, knowledge on how litter decomposition rate would respond to these seasonal precipitation changes is still limited. In the present study, we conducted a precipitation manipulation experiment in a tropical forest. First, we applied a 60% rainfall exclusion in April and May to defer the onset of wet season and added the same amount of water in October and November to mimic a deferred wet season (DW); second, we increased as much as 25% mean annual precipitation into plots in July and August to simulate a wetter wet season (WW). Five single-species litters, with their carbon to nitrogen ratio ranged from 27 to 49, and a mixed litter were used to explore how the precipitation change treatments would affect litter decomposition rate. The interaction between precipitation changes and litter species was not significant. The DW treatment marginally accelerated litter decomposition across six litter types. Detailed analysis showed that DW increased litter decomposition rate in the periods of January to March and October to December, when soil moisture was increased by the water addition in the dry season. In contrast, WW did not significantly affect litter decomposition rate, which was consistent with the unchanged soil moisture pattern. In conclusion, the study indicated that regardless of litter types or litter quality, the projected deferred wet season would increase litter decomposition rate, whereas the wetter wet season would not affect litter decomposition rate in the tropical forests. This study improves our knowledge of how tropical forest carbon cycling in response to precipitation change.

2.
Environ Technol ; 39(16): 2138-2150, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28678620

RESUMO

Untreated water from mining sites spreads heavy metal contamination. The present study assessed the phytoextraction performance of heavy metal-accumulating plants and the effects of chemical chelators on cadmium (Cd), lead (Pb), zinc (Zn), and copper (Cu) removal from paddy fields that have been continuously irrigated with mining wastewater from mines for 55 years. Outdoor pot experiments showed that the total Pb, Zn, and Cd content was lower in the rhizosphere soil of Amaranthus hypochondriacus than in that of Sedum alfredii, Solanum nigrum, and Sorghum bicolor. The aboveground biomass (dry weight) and relative growth rate of A. hypochondriacus were significantly higher than that of the other three species (P < .05). However, the total metal accumulation was significantly higher in the A. hypochondriacus system than in the other plants' system (P < .05). The increase in shoot biomass of A. hypochondriacus depended mostly on the chelator type [ethylenediaminetetraacetic acid (EDTA), malate, oxalate, and citrate] and their application frequency. Single application of EDTA significantly increased the shoot biomass of A. hypochondriacus and total metal removal loading from soil (P < .05). In conclusion, A. hypochondriacus may be effective for in situ phytoremediation of heavy metal-contaminated farmland soil and EDTA can accelerate the phytoextraction effect.


Assuntos
Irrigação Agrícola , Poluentes do Solo , Águas Residuárias , Biodegradação Ambiental , Quelantes , Chumbo , Metais Pesados , Solo , Zinco
3.
Oncotarget ; 8(43): 75361-75371, 2017 Sep 26.
Artigo em Inglês | MEDLINE | ID: mdl-29088871

RESUMO

FoxP3+ regulatory T cells (FoxP3+ Tregs) are considered to be a key mediator in immune escape and tumor progression. However, the role of FoxP3+ Tregs in human colorectal cancer (CRC) remains controversial. Herein, we conducted a meta-analysis including 17 published studies with 3811 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating FoxP3+ Tregs in human CRC. We found FoxP3+ Tregs infiltrating into both intraepithelium and stroma within tumor were significantly positively correlated with 1, 3, 5 and 10-year overall survival (OS), but not with 1, 3, 5-year disease-free survival (DFS) of patients. Interestingly, in stratified analyses by compartments within tumor FoxP3+ Tregs infiltrating into, FoxP3+ Tregs invading stromal compartment significantly improved 3 and 5-year OS, yet OS wasn't improved when FoxP3+ Tregs infiltrated into intraepithelium only. Furthermore, FoxP3+ Tregs invading both intraepithelium and stroma significantly inversely correlated with TNM stage of CRC. In conclusion, High density of FoxP3+ Tregs within tumor especially at stromal compartment leads to a favorable outcome in CRC, implicating FoxP3+ Tregs are one of valuable indexes for prognostic prediction in human CRC.

4.
Oncotarget ; 8(39): 66382-66391, 2017 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-29029520

RESUMO

IL-17A is an important proinflammatory cytokine which is frequently elevated in tumor microenvironment. However, the role of intratumoral IL-17A in solid tumors remains controversial. Herein, we conducted a meta-analysis to assess the prognostic impact of intratumoral IL-17A in patients with solid tumor. PubMed and EBSCO were searched to identify the studies evaluating the associations between intratumoral IL-17A measured by immunohistochemistry (IHC) and overall survival (OS) and disease-free survival (DFS) in solid tumors. A total of 2972 patients with solid tumor from 21 published studies were incorporated into this meta-analysis. We found that high level of intratumoral IL-17A was significantly associated with worse 3-year, 5-year OS and 1-year, 3-year DFS, but not with 1-year OS or 5-year DFS in solid tumors. In addition, in stratified analyses by cancer types, IL-17A overexpression was significantly associated with worse OS in hepatic carcinoma, but with improved OS in esophageal squamous cell carcinoma (ESCC). Furthermore, high IL-17A expression positively correlated with advanced TNM stage. In conclusion, High expression of intratumoral IL-17A leads to an unfavorable clinical outcome in majority of solid tumors, implicating IL-17A is a valuable biomarker for prognostic prediction of human solid malignances and targeting it may have a potential for effective treatment.

5.
Sci Rep ; 6: 19770, 2016 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-26794649

RESUMO

Nitrogen availability and tree species selection play important roles in reforestation. However, long-term field studies on the effects and mechanisms of tree species composition on N transformation are very limited. Eight years after tree seedlings were planted in a field experiment, we revisited the site and tested how tree species composition affects the dynamics of N mineralization and nitrification. Both tree species composition and season significantly influenced the soil dissolved organic carbon (DOC) and nitrogen (DON). N-fixing Acacia crassicarpa monoculture had the highest DON, and 10-mixed species plantation had the highest DOC. The lowest DOC and DON concentrations were both observed in Eucalyptus urophylla monoculture. The tree species composition also significantly affected net N mineralization rates. The highest rate of net N mineralization was found in A. crassicarpa monoculture, which was over twice than that in Castanopsis hystrix monoculture. The annual net N mineralization rates of 10-mixed and 30-mixed plantations were similar as that of N-fixing monoculture. Since mixed plantations have good performance in increasing soil DOC, DON, N mineralization and plant biodiversity, we recommend that mixed species plantations should be used as a sustainable approach for the restoration of degraded land in southern China.


Assuntos
Conservação dos Recursos Naturais , Nitrificação , Nitrogênio/análise , Solo/química , Compostos de Amônio/análise , Carbono/análise , China , Compostos Orgânicos/análise , Árvores/fisiologia , Água/química
6.
Eur Heart J Cardiovasc Imaging ; 17(5): 512-22, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-26710817

RESUMO

AIMS: Currently, available Doppler echocardiographic reference values are derived mainly from North American and European population studies, which may not applicable to the Chinese population. We aimed to establish normal reference values of Doppler echocardiographic parameters in a nationwide, population-based cohort of healthy Han Chinese adults. METHODS AND RESULTS: A total of 1394 qualified healthy subjects (mean age 47.3 ± 16.0 years, 678 men) were enrolled at 43 collaborating laboratories, 37 transvalvular flow and tissue Doppler parameters were obtained, and the impacts of gender and age on each parameter were analysed. Significant differences were found between men and women in 48.6% (18/37) of the parameters analysed, and among different age groups in 83.8% (31/37) of the parameters in men and in 86.5% (32/37) of the parameters in women. CONCLUSIONS: Normal reference values of Doppler echocardiographic parameters were established for the first time in a nationwide, population-based cohort of healthy Han Chinese adults. Since most of these parameters differed by gender and/or age, reference values specified for gender and age should be recommended in clinical practice.


Assuntos
Ecocardiografia Doppler/métodos , Átrios do Coração/diagnóstico por imagem , Ventrículos do Coração/diagnóstico por imagem , Adolescente , Adulto , Distribuição por Idade , Idoso , Índice de Massa Corporal , China , Feminino , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Valores de Referência , Reprodutibilidade dos Testes , Fatores de Risco , Distribuição por Sexo , Função Ventricular Esquerda/fisiologia
7.
J Matern Fetal Neonatal Med ; 29(3): 493-503, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-25731651

RESUMO

OBJECTIVE: To provide a basis for evaluating the prognosis of small left heart system development in fetuses, we analyzed its related factors. METHODS: The fetal echocardiogram was performed in 3859 pregnant women, and then small left heart system development was identified in 69 fetuses. The data of prenatal and postnatal echocardiograms, postnatal cardiac surgical treatment, chromosome and autopsy after induced labor were analyzed in the 69 fetuses. RESULTS: Except 1320 cases losing follow-up, 2539 cases had complete data. Among the 2539 cases, small left heart system development was identified in 69 fetuses. Of the 69 fetuses, 12 had hypoplastic left heart syndrome, 20 premature closure of foramen ovale, 13 total anomalous pulmonary venous drainage, 2 common pulmonary vein lumen atresia, 21 aortic coarctation or interruption and 1 right pulmonary hypoplasia. Among the 69 fetuses, chromosome abnormality was found in 7. CONCLUSION: There are many etiological factors causing small left heart system development. The prognosis is poor in the fetuses with hypoplastic left heart syndrome, common pulmonary vein lumen atresia, pulmonary hypoplasia, other malformations or/and chromosome abnormality. Fetal echocardiography combined with chromosome examination can provide important bases for making diagnosis and evaluating the prognosis regarding small left heart system development.


Assuntos
Doenças Fetais/etiologia , Cardiopatias Congênitas/etiologia , Adolescente , Adulto , Ecocardiografia , Feminino , Doenças Fetais/diagnóstico por imagem , Cardiopatias Congênitas/diagnóstico por imagem , Humanos , Cariótipo , Pessoa de Meia-Idade , Gravidez , Prognóstico , Estudos Prospectivos , Reprodutibilidade dos Testes , Ultrassonografia Pré-Natal , Adulto Jovem
8.
Ultrasound Med Biol ; 42(1): 272-81, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26520563

RESUMO

Speckle-tracking echocardiography was used to assess retrograde coronary venous infusion of mesenchymal stem cells (MSCs) combined with basic fibroblast growth factor (bFGF) in a canine model of acute myocardial infarction (AMI). AMI was induced by ligation of the left anterior descending coronary artery. Coronary venous retroperfusion was performed at 1 wk after AMI. Twenty-eight animals were randomized into four groups: saline, bFGF+saline, saline+MSCs and bFGF+MSCs. Echocardiography was performed before AMI, at 7 d post-AMI and 40 d after retroperfusion. Apoptotic cardiomyocytes in the border zone of the ischemic region were evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling. Vascular endothelial growth factor and factor VIII concentrations were measured by western blotting. The left ventricular end-systolic volume increased significantly, whereas the left ventricular ejection fraction and global and segmental strain values decreased significantly after AMI. After retroperfusion, the strain values of the infarct zone, but not conventional echocardiographic parameters, were significantly different between control and bFGF+MSC groups. Cardiomyocyte apoptosis decreased, whereas vascular endothelial growth factor and factor VIII concentrations were higher in the bFGF+MSC, bFGF and MSC groups. Cardiomyocyte apoptosis was well correlated with the strain values. Although retrograde coronary venous infusion of bFGF and MSCs promoted neo-vascularization of the infarcted myocardium and inhibited apoptosis, there was only a slight strain improvement without a substantial increase in global cardiac functions.


Assuntos
Vasos Coronários/diagnóstico por imagem , Fator 2 de Crescimento de Fibroblastos/uso terapêutico , Transplante de Células-Tronco Mesenquimais/métodos , Células-Tronco Mesenquimais , Infarto do Miocárdio/terapia , Doença Aguda , Animais , Western Blotting , Modelos Animais de Doenças , Cães , Feminino , Marcação In Situ das Extremidades Cortadas , Masculino , Infarto do Miocárdio/diagnóstico por imagem , Cloreto de Sódio/administração & dosagem , Ultrassonografia
9.
J Am Soc Echocardiogr ; 28(5): 570-9, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25753502

RESUMO

BACKGROUND: Currently available echocardiographic reference values are derived mainly from North American and European population studies, and no echocardiographic reference values are available for the Chinese population. The aim of this study was to establish normal values of echocardiographic measurements of the cardiac chambers and great arteries in a nationwide, population-based cohort of healthy Han Chinese adults. METHODS: A total of 1,586 healthy Han Chinese volunteers aged 18 to 79 years were screened at 43 collaborating laboratories throughout China. Standard M-mode and two-dimensional echocardiography was performed to obtain measurements of the cardiac chambers and great arteries. The impacts of gender and age on all echocardiographic measurements were analyzed. RESULTS: A total of 1,394 qualified healthy subjects (mean age, 47.3 ± 16.0 years; 678 men) were ultimately enrolled. Except for left ventricular ejection fraction, values of cardiac chamber and great arterial dimensions were significantly higher in men than in women. Most measurements of the atrial and great arterial dimensions, left ventricular wall thickness, and left ventricular mass increased with age in both men and women. CONCLUSIONS: Normal reference values of cardiac dimensional parameters were established for the first time in a nationwide, population-based cohort of healthy Han Chinese adults. Because most of these parameters were found to vary with gender and age, reference values stratified for gender and age should be used in clinical practice.


Assuntos
Artérias/diagnóstico por imagem , Ecocardiografia/métodos , Átrios do Coração/diagnóstico por imagem , Ventrículos do Coração/diagnóstico por imagem , Função Ventricular Esquerda/fisiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , China , Feminino , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Valores de Referência , Reprodutibilidade dos Testes , Adulto Jovem
10.
Chin Med J (Engl) ; 128(2): 226-32, 2015 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-25591567

RESUMO

BACKGROUND: Strain and strain-rate imaging (SRI) have been found clinically useful in the assessment of cardiac systolic and diastolic function as well as providing new insights in deciphering cardiac physiology and mechanics in cardiomyopathies, and identifying early subclinical changes in various pathologies. The aim of this study was to evaluate the regional and global left ventricular (LV) myocardial function in metabolic syndrome (MS) with SRI so that we can provide more myocardial small lesions in patients with MS, which is robust and reliable basis for early detection of LV function. METHODS: Thirty-nine adults with MS were enrolled in the study. There was a control group of 39 healthy adults. In addition to classic echocardiographic assessment of LV global functional changes, SRI was used to evaluate regional and global LV function. Including: Peak systolic strain (S), peak systolic strain-rate (SR-s), peak diastolic strain-rate (SR-e). RESULTS: There were no statistically significant differences between MS and controls in all traditional parameters of LV systolic function. On the other hand, significant differences were observed between MS and the control group in most of the parameters of S, SR-s, SR-e in regional LV function. Multiple stepwise regression analyses revealed that S and SR significantly were negatively correlated with blood pressure, waist circumference, fasting plasma glucose, uric acid, suggesting that risk factories were relevant to regional systolic dysfunction. CONCLUSION: In MS with normal LV ejection fraction, there was regional myocardial dysfunction, risk factors contributed to the impairment of systolic and diastolic function of the regional myocardium. Assessment of myocardial function using SRI could be more accurate in MS patient evaluation than conventional echocardiography alone.


Assuntos
Síndrome Metabólica/fisiopatologia , Função Ventricular Esquerda/fisiologia , Ecocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
11.
Oncol Lett ; 8(6): 2553-2556, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25364426

RESUMO

Fetal cardiac rhabdomyoma is the most common cardiac tumor in fetuses. However, this benign tumor can cause hemodynamic repercussions and intrauterine fetal mortality. The present study reports a case of rare fetal cardiac rhabdomyoma located in the right atrium, accompanied by premature restriction of the foramen ovale and moderate pericardial effusion, as determined by tomographic ultrasound imaging (TUI). Fetal mortality subsequently occurred late in the second trimester of pregnancy and the diagnosis was confirmed by pathology. The present study discusses the occurrence and diagnosis of this rare abnormality. TUI mode with spatio-temporal image correlation offline imaging provides the physician with clear views of abnormal intracardiac structures in the beating heart. With improvements in sonographic technology, the diagnosis of fetal cardiac rhabdomyoma may be easier and more accurate in the clinical arena.

12.
Int J Cardiol ; 176(1): 80-5, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25042658

RESUMO

INTRODUCTION: Right ventricular (RV) pacing may affect myocardial perfusion and coronary blood flow; however, it remains unknown whether this is related to systolic dyssynchrony induced by RV pacing. This prospective study was aimed to assess the relationship between dyssynchrony and the changes of coronary blood flow. METHODS: Seventy patients with sinus node dysfunction were prospectively enrolled. Coronary flow was evaluated by measuring diastolic velocity time integral (VTI) and duration at the distal-portion of left anterior descending coronary artery (LAD) with transthoracic echocardiography at baseline and follow-up. Systolic dyssynchrony was assessed with tissue Doppler imaging by time standard deviation to peak systolic velocity of 12 left ventricular segments (Ts-SD, cutoff value ≥ 33 ms). RESULTS: Adequate data for analysis was available from 65 patients. At follow-up (mean follow up time: 127 ± 45 days), LAD velocity-time integral (LAD-VTI: 12.1 ± 4.2 vs. 10.7 ± 4.6 cm, p<0.001) was decreased and there was deterioration of left ventricular systolic function (left ventricular ejection fraction: 65 ± 7% vs. 62 ± 7%). However, these changes were only detected in those with RV pacing induced systolic dyssynchrony. Significant reduction of LAD-VTI (defined as ≥ 5%) occurred in 34 (52%) patients which was more prevalent in those with pacing-induced systolic dyssynchrony than those without (85.3% versus 16.1%, χ(2)=31.1, p<0.001). Though similar at baseline, LAD-VTI was significantly lower in the dyssynchrony group at follow up (p<0.001). Cox-regression analysis showed that pacing-inducing systolic dyssynchrony [hazard ratio (HR): 3.62, p=0.009] and higher accumulative pacing percentage (HR: 1.02, p=0.002) were independently associated with reduction of LAD-VTI. ROC curve demonstrated that accumulative pacing percentage ≥ 35% was 97% sensitive and 84% specific in revealing significant reduction (area under the curve: 0.961, p<0.001). CONCLUSIONS: RV pacing induced dyssynchrony is associated with reduced coronary flow and this may account for, in part, the deleterious effect of RV pacing on ventricular function over time.


Assuntos
Pressão Sanguínea , Vasos Coronários/diagnóstico por imagem , Vasos Coronários/fisiopatologia , Disfunção Ventricular Direita/diagnóstico por imagem , Disfunção Ventricular Direita/fisiopatologia , Velocidade do Fluxo Sanguíneo , Ecocardiografia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Sístole
13.
Environ Sci Pollut Res Int ; 21(16): 9921-30, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24801288

RESUMO

The effects of several silicates (talcum powder (TP), calcium silicate (CS), sodium silicate (SS), and potassium silicate (PS)), in comparison with other amendments (quicklime (QL) and potassium dihydrogen phosphate (PDP)) on cadmium (Cd) uptake by three dicotyledonous crops (Amaranthus hypochondriacus L. Cv. 'K112', Amaranthus tricolor L., and Brassica oleracea var. albiflora Kuntze) were investigated in Cd-contaminated soil. The effects of both application methods of amendments (singly and combined) and timing of application were also evaluated. Sodium silicate was the most effective in reducing crop Cd uptake and translocation, which was diminished by 51% in roots, 53% in stems, and 72% in leaves on average. Application of CS amendment showed greater efficiency than PDP amendment in decreasing Cd uptake by crops and resulted in increased biomass. Potassium silicate only slightly decreased shoot Cd concentration. Combination of PDP and SS was able to overcome the inhibitory effect of SS on crop yield while decreasing Cd concentrations in roots, stems and leaves of the tested crops by average rates of 52, 65, and 68% respectively. Applications of SS and PS significantly reduced the root-to-shoot Cd transfer factor. We found that Si accumulation in crops was not associated with lower Cd concentration, indicating that Si in crops may play a major role in alleviating metal stress rather than inhibiting crop Cd accumulation. We suggested that the inhibitive effect of silicates on crops Cd uptake was majorly attributed to the properties of the silicates, those were their specific effects on soil pH and cations, which increased Cd adsorption by soil and suppressed Cd uptake from soil solution by increasing the relative dissolved concentrations of competing cations.


Assuntos
Agricultura/métodos , Amaranthus/metabolismo , Brassica/metabolismo , Cádmio/metabolismo , Produtos Agrícolas/metabolismo , Silicatos/farmacologia , Poluentes do Solo/metabolismo , Adsorção , Amaranthus/efeitos dos fármacos , Amaranthus/crescimento & desenvolvimento , Transporte Biológico/efeitos dos fármacos , Biomassa , Brassica/efeitos dos fármacos , Brassica/crescimento & desenvolvimento , Cádmio/análise , Produtos Agrícolas/efeitos dos fármacos , Produtos Agrícolas/crescimento & desenvolvimento , Raízes de Plantas/efeitos dos fármacos , Poluentes do Solo/análise
14.
Chin Med J (Engl) ; 126(22): 4222-6, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24238501

RESUMO

BACKGROUND: Cardiac resynchronization therapy (CRT) with biventricular pacing has demonstrated cardiac function improvement for treating congestive heart failure (HF). It has been documented that the placement of the left ventricular lead at the longest contraction delay segment has the optimal CRT benefit. This study described follow-up to surgical techniques for CRT as a viable alternative for patients with heart failure. METHODS: Between April 2007 and June 2012, a total of 14 consecutive heart failure patients with New York Heart Association (NYHA) Class III-IV underwent left ventricular epicardial lead placements via surgical approach. There were eight males and six females, aged 36 to 79 years ((59.6 ± 9.2) years). The mean left ventricular ejection fraction (LVEF) was (33.6 ± 7.4)%. All patients were treated with left ventricular systolic dyssynchrony and underwent left ventricular epicardial lead placements via a surgical approach. Tissue Doppler imaging (TDI) and intraoperative transesophageal echocardiography were used to assess changes in left heart function and dyssynchronic parameters. Also, echo was used to select the best site for left ventricular epicardial lead placement. RESULTS: Left ventricular epicardial leads were successfully implanted in the posterior or lateral epicardial wall without serious complications in all patients. All patients had reduction in NYHA score from III-IV preoperatively to II-III postoperatively. The left ventricular end-diastolic diameter (LVEDD) decreased from (67.9 ± 12.7) mm to (61.2 ± 7.1) mm (P < 0.05), and LVEF increased from (33.6 ± 7.4)% to (42.2 ± 8.8)% (P < 0.05). Left ventricular intraventricular dyssynchrony index decreased from (148.4 ± 31.6) ms to (57.3 ± 23.8) ms (P < 0.05). CONCLUSIONS: Minimally invasive surgical placement of the left ventricular epicardial lead is feasible, safe, and efficient. TDI can guide the epicardial lead placement to the ideal target location.


Assuntos
Terapia de Ressincronização Cardíaca/métodos , Ecocardiografia/métodos , Adulto , Idoso , Feminino , Insuficiência Cardíaca/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
15.
Ultrasound Med Biol ; 39(11): 2044-52, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23993171

RESUMO

Ultrasound bio-microscopy was used to measure hemodynamic changes in the left main coronary artery after myocardial infarction (MI), and its usefulness in estimating infarct size was evaluated. MI was induced by left anterior descending artery ligation. Diastolic peak velocity (Vd), mean flow velocity (Vmean) and the velocity-time integral (VTI) were measured 2 and 6 h after MI. Serum troponin I levels were assayed 2, 6 and 12 h after MI. At 2 h, Vmean and VTI significantly differed between mice that underwent low and high left anterior descending artery ligation; Vd, Vmean and VTI were correlated with infarct size (r = -0.557, -0.693 and -0.672, respectively; all p < 0.01). Infarct size was more strongly correlated with 2-h ultrasound bio-microscopy measurements than with 2-h serum troponin I level. Measurement of coronary artery blood flow by ultrasound bio-microscopy may be useful for early estimation of infarct size in mice.


Assuntos
Circulação Coronária , Interpretação de Imagem Assistida por Computador/métodos , Microscopia Acústica/métodos , Infarto do Miocárdio/diagnóstico por imagem , Infarto do Miocárdio/fisiopatologia , Animais , Velocidade do Fluxo Sanguíneo , Modelos Animais de Doenças , Humanos , Camundongos , Camundongos Endogâmicos C57BL , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
16.
J Ultrasound Med ; 32(7): 1291-4, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23804352

RESUMO

Premature closure or restriction of the foramen ovale may occur at any time during pregnancy and may be due to various causes. We describe 2 patients with premature closure or restriction of the foramen ovale during the third trimester. In both patients the foramen ovale was detected by directional enhanced flow imaging technology (DeFLOW; Hitachi-Aloka Medical, Ltd, Tokyo, Japan), a novel method of imaging blood flow dynamics. Our findings indicate that D-eFLOW can display blood flow information with higher sensitivity and resolution than conventional methods, helping obstetricians and pregnant women make timely decisions about delivery.


Assuntos
Forame Oval Patente/diagnóstico por imagem , Forame Oval Patente/embriologia , Ultrassonografia Doppler em Cores/métodos , Ultrassonografia Pré-Natal/métodos , Adulto , Velocidade do Fluxo Sanguíneo , Feminino , Forame Oval Patente/fisiopatologia , Humanos , Gravidez
17.
Exp Ther Med ; 5(5): 1501-1505, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23737907

RESUMO

The aim of this study was to determine the diagnostic value of an ROC curve of the antepartum foramen ovale (AFO) size and the ratio of FO size to aorta (AO) size (FO/AO) for the prediction of puerperal atrial septal defect in different gestational weeks (DGWs). A total of 958 cases were divided into five groups according to number of gestational weeks. Comparisons of FO size, AO size and FO/AO were determined by variance analysis. The correlations between FO size, AO size and gestational age were determined using regression analysis and comparisons between atrial septal defect (ASD) diagnosed in DGWs and normal cardiac FO size and FO/AO were analyzed by t-test. ROC curve analysis was used for FO size and FO/AO to predict the demarcation point of puerperal ASD (pASD). The differences between FO size and AO size in the five groups at DGWs were statistically significant (P=0.000). The sizes of FO and AO increased with gestational age. The differences among pASD, normal cardiac FO size and FO/AO were statistically significant (P=0.000). FO size in the five DGW groups (18-22, 23-26, 27-30, 31-34 and 35-40 weeks) was able to predict the demarcation points of pASD, which were 5.02, 5.15, 6.55, 8.55 and 7.90 mm, respectively. The prediction of pASD with AFO size and FO/AO was accurate and may provide reliable reference values in the clinic.

18.
Pest Manag Sci ; 69(6): 679-84, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23529853

RESUMO

BACKGROUND: Herbicides are used extensively to control weeds. However, little is known about the non-target effects of herbicides on soil nematode assemblages. The objective of this study was to determine whether herbicides affect the abundance of nematodes in specific trophic groups. Meta-analysis was performed, and the calculated effect size, lr, quantified the impact of herbicides on the abundance of total nematodes and five trophic groups (bacterivores, fungivores, plant parasites, omnivores and predators). RESULTS: Measurements of lr indicated that herbicides decreased abundance of both fungivores and predators; however, abundance of bacterivores, plant parasites and omnivores increased. Overall, total nematode abundance tended to increase in response to herbicide application. CONCLUSION: The decrease in predator abundance suggests that herbicide application disturbs soil food webs. The increase in bacterivore and decrease in fungivore abundance suggest that bacterivores are more tolerant and both fungivores and predators more sensitive to herbicide applications. Herbicides also have non-target effects on omnivores, which may be due to the increased amount of food resources for omnivores after weed control. Additionally, the use of herbicides may result in a risk of an increase in plant-parasitic nematode abundance.


Assuntos
Herbicidas/farmacologia , Nematoides/efeitos dos fármacos , Animais , Ecossistema , Nematoides/classificação , Nematoides/crescimento & desenvolvimento , Solo/parasitologia
19.
Environ Sci Pollut Res Int ; 20(8): 5844-54, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23508535

RESUMO

Mining effluents are a potential source of toxic metals in the surrounding aquatic ecosystem and pose a potential health risk to humans from fish consumption. The objective of this paper is to assess the impact of the long-term Dabaoshan mining operation on heavy metal accumulation in different fish species. Heavy metal accumulation (lead (Pb), cadmium (Cd), zinc (Zn), and copper (Cu)) in four tissues (liver, muscle, intestine, and gills) of five carp species (Hypophthalmichthys molitrix, Ctenopharyngodon idellus, Megalobrama amblycephala, Aristichthys nobilis, and Carassius auratus auratus) from two fishponds exposed to effluent waters from Dabaoshan mine, South China. The bioaccumulation factor (BAF) and target hazard quotients were calculated to assess potential health risks to local residents through fish consumption. Levels of heavy metals varied depending on the analyzed tissues. C. auratus auratus accumulated the higher Pb, Cd, Zn, and Cu in the intestine compared with other fish species. Liver of all five species contained high concentrations of Pb, Cd, Zn, and Cu. The BAF for the studied metals showed a descending order of Cd>Zn>Cu>Pb for fishpond 1 and Zn>Cd>Cu>Pb for fishpond 2. Risk assessments suggested that potential human health risk may be present due to high Pb and Cd concentration in the muscle of some fish species exceeding the national and international limits, although the target hazard quotients were less than one.


Assuntos
Carpas , Contaminação de Alimentos/análise , Metais Pesados/análise , Poluentes Químicos da Água/análise , Animais , China , Monitoramento Ambiental , Sedimentos Geológicos/análise , Brânquias/química , Humanos , Intestinos/química , Fígado/química , Mineração , Músculos/química , Tanques , Medição de Risco
20.
Cardiol Young ; 23(2): 219-24, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22647298

RESUMO

OBJECTIVE: To study coronary artery haemodynamics in adolescents with homozygous familial hypercholesterolaemia and aortic supravalvular stenosis. METHODS: Patients diagnosed with familial hypercholesterolaemia who were younger than 16 years and who had undergone transthoracic echocardiography from 2007 to 2010 were included in this study. We included patients with homozygous familial hypercholesterolaemia and aortic supravalvular stenosis and those with heterozygous familial hypercholesterolaemia. All patients underwent stress echocardiography, and left anterior descending coronary artery flow was successfully detected. Coronary flow velocity reserve was calculated as the ratio of hyperaemic mean diastolic flow velocity after injection of adenosine to basal mean diastolic flow velocity. Changes in coronary haemodynamics and the relationship between lipid concentrations were determined. RESULTS: A total of 11 patients with homozygous familial hypercholesterolaemia were enrolled in this study. Lipid concentrations were measured, and the mean coronary flow velocity reserve was 1.97 plus or minus 0.51. Seven children were included in the group of patients with heterozygous familial hypercholesterolaemia. In these children, the mean coronary flow velocity reserve was 3.08 plus or minus 0.84. CONCLUSION: The coronary flow velocity reserve of homozygous familial hypercholesterolaemic patients is lower than that of heterozygous familial hypercholesterolaemic patients, and it is associated with a high concentration of low-density lipoprotein cholesterol. Aortic stenosis and plaques compromised the ostia of the coronary artery and caused increased basal mean diastolic coronary velocity with blunted increase in peak velocity, which decreased the coronary flow velocity reserve.


Assuntos
Estenose Aórtica Supravalvular/fisiopatologia , Circulação Coronária/fisiologia , Hemodinâmica/fisiologia , Hiperlipoproteinemia Tipo II/fisiopatologia , Adolescente , Estenose Aórtica Supravalvular/complicações , Estenose Aórtica Supravalvular/diagnóstico por imagem , Velocidade do Fluxo Sanguíneo , Criança , Ecocardiografia Doppler de Pulso , Ecocardiografia sob Estresse , Feminino , Heterozigoto , Homozigoto , Humanos , Hiperlipoproteinemia Tipo II/complicações , Hiperlipoproteinemia Tipo II/diagnóstico por imagem , Masculino
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